Aliases & Classifications for Infertility

MalaCards integrated aliases for Infertility:

Name: Infertility 12 29 54 6 42 3 44 15 62 39 17 71

Classifications:



External Ids:

Disease Ontology 12 DOID:5223
MeSH 44 D007246
NCIt 50 C3836
SNOMED-CT 67 8619003
UMLS 71 C0021359

Summaries for Infertility

MedlinePlus : 42 Infertility means not being able to become pregnant after a year of trying. If a woman can get pregnant but keeps having miscarriages or stillbirths, that's also called infertility. Infertility is fairly common. After one year of having unprotected sex, about 15 percent of couples are unable to get pregnant. About a third of the time, infertility can be traced to the woman. In another third of cases, it is because of the man. The rest of the time, it is because of both partners or no cause can be found. There are treatments that are specifically for men or for women. Some involve both partners. Drugs, assisted reproductive technology, and surgery are common treatments. Happily, many couples treated for infertility go on to have babies. NIH: National Institute of Child Health and Human Development

MalaCards based summary : Infertility is related to spermatogenic failure 5 and male infertility, and has symptoms including pelvic pain An important gene associated with Infertility is H19 (H19 Imprinted Maternally Expressed Transcript), and among its related pathways/superpathways are DAG and IP3 signaling and cAMP signaling pathway. The drugs Dienogest and Estrone have been mentioned in the context of this disorder. Affiliated tissues include ovary, testis and uterus, and related phenotypes are cellular and endocrine/exocrine gland

CDC : 3 In general, infertility is defined as not being able to get pregnant (conceive) after one year (or longer) of unprotected sex. Because fertility in women is known to decline steadily with age, some providers evaluate and treat women aged 35 years or older after 6 months of unprotected sex. Women with infertility should consider making an appointment with a reproductive endocrinologist-a doctor who specializes in managing infertility. Reproductive endocrinologists may also be able to help women with recurrent pregnancy loss, defined as having two or more spontaneous miscarriages.

PubMed Health : 62 About infertility: Not being able to have children is often a source of great emotional turmoil. Many men and women take it for granted that they will be able to have children. If they are not able to conceive, many couples start looking for medical help at some point. A number of different treatments are available, depending on the possible causes of infertility. Problems conceiving a child are defined by medical experts as “infertility” if a couple has had regular unprotected sex for one year without the woman becoming pregnant.

Wikipedia : 74 Infertility is the inability of a person, animal or plant to reproduce by natural means. It is usually... more...

Related Diseases for Infertility

Diseases in the Infertility family:

Infertility Due to Extratesticular Cause

Diseases related to Infertility via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 999)
# Related Disease Score Top Affiliating Genes
1 spermatogenic failure 5 33.2 DPY19L2 AURKC
2 male infertility 32.7 NR5A1 NPHP4 LHCGR LHB INHA FSHR
3 oocyte maturation defect 1 32.6 TUBB8 CYP19A1
4 spermatogenic failure 7 32.6 CATSPER2 CATSPER1
5 spermatogenic failure 9 32.5 EPPIN DPY19L2 DNAH1 CATSPER1 AURKC
6 hypogonadotropic hypogonadism 32.4 NR5A1 LHCGR LHB FSHB CYP19A1
7 catsper-related male infertility 32.2 CATSPER2 CATSPER1
8 anovulation 32.1 FSHR FSHB CYP19A1
9 oligospermia 32.0 EPPIN DAZL CFTR
10 cryptorchidism, unilateral or bilateral 32.0 NR5A1 LHCGR FSHR EPPIN DAZL CYP19A1
11 spermatogenic failure 50 32.0 NR5A1 EPPIN DPY19L2 DAZL CATSPER1 AURKC
12 female infertility due to zona pellucida defect 32.0 ZP3 ZP2
13 primary ciliary dyskinesia 32.0 NPHP4 DPY19L2 DNAH1 CFTR CATSPER1
14 premature menopause 31.8 ZP3 ZP2 NR5A1 LHCGR INHA FSHR
15 male infertility with azoospermia or oligozoospermia due to single gene mutation 31.8 NR5A1 CFTR
16 kartagener syndrome 31.6 NPHP4 DNAH1 CFTR CATSPER1
17 hypogonadotropic hypogonadism 23 without anosmia 31.6 LHB EPPIN
18 amenorrhea 31.5 NR5A1 LHCGR LHB FSHR FSHB CYP19A1
19 ovarian hyperstimulation syndrome 31.4 LHCGR FSHR FSHB CYP19A1
20 ovarian disease 31.1 ZP3 LHCGR FSHR EPPIN CYP19A1
21 hypogonadism, male 30.9 LHCGR LHB
22 leydig cell tumor 30.7 NR5A1 LHCGR INHA CYP19A1
23 precocious puberty 30.6 LHCGR FSHR
24 estrogen excess 30.4 FSHR EPPIN CYP19A1
25 46 xx gonadal dysgenesis 30.3 NR5A1 LHCGR FSHR
26 prostatic cyst 30.3 FSHR EPPIN
27 disorder of sexual development 30.3 NR5A1 LHCGR FSHR EPPIN CYP19A1
28 pseudohermaphroditism 30.2 NR5A1 LHCGR LHB FSHR EPPIN CYP19A1
29 adrenal rest tumor 30.2 NR5A1 EPPIN
30 mucinous cystadenofibroma 30.1 LHCGR FSHR
31 twinning, dizygotic 30.1 INHA FSHR
32 germ cell cancer 29.4 LHCGR H19 FSHR
33 deafness-infertility syndrome 11.6
34 y chromosome infertility 11.6
35 spermatogenic failure 1 11.5
36 spermatogenic failure 6 11.5
37 endometriosis 11.4
38 young syndrome 11.3
39 azoospermia 11.3
40 catsper1-related nonsyndromic male infertility 11.3
41 male infertility with teratozoospermia due to single gene mutation 11.3
42 polycystic ovary syndrome 11.3
43 heterotaxy, visceral, 9, autosomal, with male infertility 11.3
44 spermatogenic failure 17 11.3
45 spermatogenic failure, y-linked, 2 11.2
46 spermatogenic failure, x-linked, 2 11.2
47 pelvic inflammatory disease 11.2
48 oligoasthenoteratozoospermia 11.1
49 spermatogenic failure 3 11.1
50 spermatogenic failure, x-linked, 1 11.1

Graphical network of the top 20 diseases related to Infertility:



Diseases related to Infertility

Symptoms & Phenotypes for Infertility

UMLS symptoms related to Infertility:


pelvic pain

MGI Mouse Phenotypes related to Infertility:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.93 CATSPER1 CATSPER2 CYP19A1 DPY19L2 FSHB FSHR
2 endocrine/exocrine gland MP:0005379 9.7 CFTR CYP19A1 DPY19L2 FSHB FSHR INHA
3 reproductive system MP:0005389 9.53 AURKC CATSPER1 CATSPER2 CFTR CYP19A1 DNAH1

Drugs & Therapeutics for Infertility

PubMed Health treatment related to Infertility: 62

There are a number of different treatments for infertility . The exact kind of treatment will mainly be determined by what sort of problem has been diagnosed in the woman or man. For instance, hormones may be used if the woman has an abnormal menstrual cycle . Surgery may be helpful if she has fibroids . Some causes of infertility in men can also be treated with hormones or surgery. If not enough sperm is produced or if the sperm cells don't move enough, the semen can be transferred directly to the woman’s womb . This procedure is called insemination. Artificial insemination is also a treatment option if the couple can't have sex or if the sperm can't pass through the cervical mucus . One alternative is artificial fertilization outside the body (in vitro fertilization, or IVF): In this procedure, eggs are removed from the woman’s ovaries through the vagina using a thin hollow needle, and then combined with sperm from the man. Before the eggs are removed, the woman has hormone therapy to stimulate her ovaries to release several mature eggs during the course of a single menstrual cycle . This hormone therapy can have very strong and unpleasant side effects. The actual fertilization takes place outside of the woman's body in a laboratory. In IVF, sperm cells are added to an egg cell and the fertilization process happens on its own. In intracytoplasmic sperm injection (ICSI), one sperm cell is injected directly into an egg using a fine needle. If the fertilization is a success and the egg cells continue to develop, the doctor implants up to three embryos into the womb . In rare cases more egg cells develop into embryos. The woman can then decide to have them frozen (cryopreserved) or destroyed. This also applies to egg cells in a stage of development called the pronuclear stage, in which the chromosome sets from the sperm and egg cells have not yet fully joined together. Cryopreserved embryos or fertilized egg cells can then be thawed out for use in a later cycle if the first transfer is not successful.

Drugs for Infertility (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 447)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dienogest Approved Phase 4 65928-58-7
2
Estrone Approved Phase 4 53-16-7 5870
3
Clopidogrel Approved Phase 4 120202-66-6, 113665-84-2 60606
4
Goserelin Approved Phase 4 65807-02-5 47725 5311128
5
Diazepam Approved, Illicit, Investigational, Vet_approved Phase 4 439-14-5 3016
6
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
7
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
8
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
9
Atosiban Approved, Investigational Phase 4 90779-69-4
10
Dimenhydrinate Approved Phase 4 523-87-5 441281
11
Levonorgestrel Approved, Investigational Phase 4 797-63-7, 17489-40-6 13109
12
Acarbose Approved, Investigational Phase 4 56180-94-0 441184
13
Danazol Approved Phase 4 17230-88-5 28417
14
Nafarelin Approved Phase 4 76932-56-4 16129618 25077649
15
Calcium polycarbophil Approved Phase 4 126040-58-2
16
Nitrous oxide Approved, Vet_approved Phase 4 10024-97-2 948
17
Adenosine Approved, Investigational Phase 4 58-61-7 60961
18
Meperidine Approved Phase 4 57-42-1 4058
19
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
20
Thiopental Approved, Vet_approved Phase 4 76-75-5 3000715
21
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
22
Cabergoline Approved Phase 4 81409-90-7 54746
23
tannic acid Approved Phase 4 1401-55-4
24
Benzocaine Approved, Investigational Phase 4 1994-09-7, 94-09-7 2337
25
Acetaminophen Approved Phase 4 103-90-2 1983
26
Heparin Approved, Investigational Phase 4 9005-49-6 772 9812414
27
Dalteparin Approved Phase 4 9005-49-6
28
Enoxaparin Approved Phase 4 9005-49-6 772
29
Tinzaparin Approved Phase 4 9041-08-1, 9005-49-6 25244225
30 Bemiparin Approved, Investigational Phase 4 91449-79-5
31
Levoleucovorin Approved, Investigational Phase 4 68538-85-2 149436
32
Iron Approved Phase 4 7439-89-6 23925 29936
33 Ethiodized oil Approved, Investigational Phase 4 8008-53-5
34
Isoniazid Approved, Investigational Phase 4 54-85-3 3767
35
Dinoprostone Approved Phase 4 363-24-6 5280360
36
Cetrorelix Approved, Investigational Phase 4 120287-85-6 16129715 25074887
37
Buserelin Approved, Investigational Phase 4 57982-77-1
38
Etonogestrel Approved, Investigational Phase 4 54048-10-1 40976 6917715
39
Trimethobenzamide Approved, Investigational Phase 4 138-56-7 5577
40
Melatonin Approved, Nutraceutical, Vet_approved Phase 4 73-31-4 896
41
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4 1406-16-2
42
Calcitriol Approved, Nutraceutical Phase 4 32222-06-3 134070 5280453
43
Ginseng Approved, Investigational, Nutraceutical Phase 4 50647-08-0
44
Cysteine Approved, Nutraceutical Phase 4 52-90-4 5862
45
Folic acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
46
Saw palmetto Experimental, Investigational Phase 4
47 Molgramostim Investigational Phase 4 99283-10-0
48
Imidacloprid Vet_approved Phase 4 105827-78-9 86418
49 Estropipate Phase 4 7280-37-7
50 Purinergic P2Y Receptor Antagonists Phase 4

Interventional clinical trials:

(show top 50) (show all 1912)
# Name Status NCT ID Phase Drugs
1 Endometrial Scratching at Time of Laproscopic Ovarian Drilling in Women With Anovulatory Infertility Due to Polycystic Ovarian Syndrome (PCOS): Randomized Controlled Trial. Unknown status NCT02140398 Phase 4
2 Induction of Ovulation by Clomiphene Citrate Following Laparoscopic Surgery for Endometriosis Stage 1 and Stage 11 With and Without Suppression by Dienogest Unknown status NCT02575248 Phase 4 Dienogest 2mg;Clomiphene citrate 5 mg
3 Structured Exerise Training in Infertile Obese Patients Treated With Assisted Reproductive Techniques: a Randomized Controlled Trial Unknown status NCT01892111 Phase 4
4 Effectiveness and Safety of uFSH for Severe Oligospermia or Azoospermia:A Multi-center,Open,Randomized,Interventional,and Phase4 Trial in China Unknown status NCT02307994 Phase 4 75IU uFSH
5 The Effect of UPA on Women Ovarian Reserve Unknown status NCT02361892 Phase 4 ulipristal acetate
6 PERCING : Ovarian Drilling Versus Ovarian Stimulation + Intra Uterine Insemination (IUI) + Metformin in the PCOS (PolyCystic Ovaries Syndrome) Treatment Unknown status NCT00378729 Phase 4 Metformin and FSHr
7 The Effectiveness and Safety of the Early Follicular Phase Prolonged Down-regulation Protocol for Controlled Ovarian Hyperstimulation: a Randomized, Paralleled, Controlled, Multicenter Trial Unknown status NCT03809221 Phase 4 Triptorelin acetate
8 Long Acting FSH Plus GnRH Antagonist Versus Daily FSH Plus GnRH Antagonist Versus Short Agonist Regimens in Poor Responder Patients Undergoing IVF: a Randomized Study. Unknown status NCT02070198 Phase 4 Long acting FSH and GnRH antagonist;Daily FSH and GnRH antagonist;Triptorelin and recombinant FSH
9 Effects of Clomiphene Citrate Ovulation Induction on Frozen Embryo Transfer Unknown status NCT03309436 Phase 4 Clomiphene Citrate protocol
10 Role of FSHR Polymorphism p.N680S in the Therapy With FSH in Patients Who Underwent Varicocele Surgery Unknown status NCT02719093 Phase 4 recombinant FSH
11 Oxidative Stress In Semen And Male Infertility Unknown status NCT03464656 Phase 4 Fairhaven Pro for men
12 An Interventional Study to Assess the Efficacy and Safety of Gonapure® in Multifollicular Stimulation in Egyptian Women Undergoing IVF/ICSI Unknown status NCT03057574 Phase 4 Follitropin Alfa
13 Follicular Fluid, Serum Endocrine Profile Following Stimulation With Recombinant Gonadotropins or Highly Purified Human Menopausal Gonadotropin During GnRH-antagonist Protocol Unknown status NCT02992808 Phase 4 recombinant gonadotropins;HP-HMG
14 Double Ovarian Stimulation as Accumulation Strategy for Older Infertile Patients With Suboptimal Ovarian Response in Assisted Reproductive Treatment Unknown status NCT03400722 Phase 4 Pergoveris;Clomiphene
15 A Randomized, the Second-generation Non-ionic Monomer Contrast Parallel Control, Multicenter Clinical Study to Evaluate the Imaging Diagnostic Quality and Fertility Promoting Effect of Ethiodized Poppyseed Oil in Hysterosalpingography of Infertile Patients. Unknown status NCT03370575 Phase 4 ethiodized poppyseed oil;the second-generation non-ionic monomer contrast
16 Transdermal Testosterone for Poor Responders Undergoing IVF Unknown status NCT03078569 Phase 4 Testosterone gel
17 The Effect of Intracervical Lidocaine Versus Intramuscular Diclofenac for Pain Relief During Hysterosalpingography Among Infertile Women In A Tertiary Hospital In Kano: A Randomized Controlled Trial Unknown status NCT02918812 Phase 4 Intracervical lidocaine;Intramuscular Diclofenac
18 Comparison of Three Different Strategies for Treating Infertility in Anovulatory Women With Polycystic Ovary Syndrome: a Multicentre Randomized Controlled Clinical Trial Unknown status NCT00461643 Phase 4 Clomiphene citrate, metformin, metformin plus clomiphene citrate, gonadotropins
19 Clinical Study of the Treatment of Infertility Caused by Severe Intrauterine Adhesions by Collagen Scaffold Loaded With Autologous Bone Marrow Stem Cells Unknown status NCT02204358 Phase 4
20 Efficacy of Long- Versus Short-term Metformin Protocol in Infertile Anovulatory PCOS Patients Unknown status NCT00501904 Phase 4 Metformin
21 The Comparison of Mild Stimulation and Controlled Ovarian Stimulation in Poor Ovarian Responders: a Prospective Randomized Study. Unknown status NCT01926210 Phase 4
22 IUI vs. IVF/ICSI in Women Aged 38-42 Years: a Prospective Randomized Controlled Trial Unknown status NCT01992731 Phase 4
23 Implantation in Frozen Embryo Transfer Unknown status NCT02655146 Phase 4 triptorelin 0.1;E2;Progesterone;triptorelin 3.75mg
24 Comparison of Assisted Reproductive Technology (ART) Outcomes Between Two Protocols of Induction of Ovulation by Using Recombinant Luteinizing Hormone (rLH) and Recombinant Follicle Stimulating Hormone (rFSH) in Patients With Hypogonadotropic Hypogonadism Unknown status NCT02140515 Phase 4 Lutropin alfa;Follitropin alfa and Lutropin alfa
25 Comparison Between Effect of Enoxaparin and Clopidogrel on Improving Pregnancy Rate in ICSI Unknown status NCT02696330 Phase 4 clopidogrel;enoxaparin;placebo
26 The Effect of LH-Priming During Early Follicular Phase on Ovarian Response and Pregnancy Outcome in GnRHa Down-Regulated Women, Stimulated With Exogenous Gonadotrophins in IVF Treatment Unknown status NCT00334425 Phase 4 MENOPUR; GONAL-F
27 G-CSF Supplemented Medium for IVF Embryo Culture in Patients Undergoing IVF Unknown status NCT02651285 Phase 4
28 Comparison Between Natural and Artificial Cycle in Recipient Oocyte Patients Unknown status NCT01353846 Phase 4 Agonist GnRH; estradiol Valerate; progesterone
29 Improving Oocyte Retrieval Using a Combined Therapy of Recombinant Follicle Stimulating Hormone (rFSH) and Inositol and Melatonin Unknown status NCT01267604 Phase 4 Recombinant FSH (rFSH)
30 Concomitant Clomiphene Citrate and Estradiol Versus Clomiphene Citrate Alone in Ovulation Induction: a Randomized Controlled Trial Unknown status NCT02186782 Phase 4 Clomiphene citrate and Estradiol;Clomiphene citrate and Placebo
31 A Comparison Study of a Novel Stimulation Protocol With Metformin in Step-down Regimen and the Conventional Low Dose Step-up Protocol in Patients With Polycystic Ovary Syndrome Undergoing in Vitro Fertilization Unknown status NCT01438190 Phase 4 Metformin, gonadotropins in step-down regimen;Placebo, gonadotropins in step-up regimen
32 Cetrorelix and Ganirelix Flexible Protocol for In Vitro Fertilization: a Prospective Randomized Trial Unknown status NCT03477929 Phase 4 Ganirelix Acetate;Cetrorelix Acetate
33 Luteal Phase Support With Progesterone vs Estrogen and Progesterone on Pregnancy Rates in Ovarian Stimulation and Intrauterine Insemination Cycles: a Prospective Randomized Study Unknown status NCT01237535 Phase 4 Luteal support with progesterone only;Luteal support with estrogen + progesterone
34 Administration of Human Chorionic Gonadotropin (hCG) Versus Gonadotropin Releasing Hormone (GnRH) Agonist for Ovulation Induction in Hyper-Responder Patients Unknown status NCT00415792 Phase 4 Arvekap, Pregnyl
35 Recombinant hCG (Ovitrelle) Vesrus Urinary hCG (Pregnyl) for Triggering Final Oocyte Maturation in High Responders Unknown status NCT00415766 Phase 4 rHCG 250ug;uHCG 5000 IU;uHCG 7500 IU
36 Randomized Controlled Trial Comparing the Long GnRH Agonist Protocol and the Flexible GnRH Antagonist Protocol of Ovarian Stimulation in Normal Responders Unknown status NCT00417183 Phase 4 Arvekap 0.1 mg (Triptorelin, Ipsen, France);Ganirelix 0.25 (Orgalutran, Organon, The Netherlands)
37 Co Administration of GnRH Agonist and hCG for Final Oocyte Maturation- A Randomized Controlled Trial Unknown status NCT02703584 Phase 4 Buseralin;pregnyl
38 Comparison of Tamoxifen and Clomiphene Citrate in Mild Stimulation IVF: a Prospective Cohort Study Unknown status NCT02690870 Phase 4 Tamoxifen;Clomiphene
39 Ovulation Induction With Clomiphene Citrate and Dexamethasone Unknown status NCT01856062 Phase 4 Placebo;Dexamethasone
40 Prospective Randomized Clinical Trial to Test the Efficacy of a Biosimilar Recombinant Follicle Stimulating Hormone (FSH)vs. Urinary FSH in an Oocyte Donation Program Unknown status NCT02503605 Phase 4 Biosimilar recombinant FSH;Urinary FSH
41 Metformin for the Treatment of Unexplained Oligozspermia and Azoospermia Unknown status NCT01529177 Phase 4 Metformin / clomid / hCG;Clomiphene citrate / hCG
42 A Prospective Randomized Trial to Analyze the Effect of the Gonadotropin Administered During Control Ovarian Stimulation on Embryo Kinetics of Development Unknown status NCT02402192 Phase 4 Corifollitropin alfa
43 Adding Prednisolone During Ovulation Induction With Clomiphene Citrate in Lean Women With Clomiphene Citrate Resistant Polycystic Ovarian Syndrome Unknown status NCT02344888 Phase 4 Clomiphene citrate and Prednisolone;Clomiphene citrate and folic acid
44 Comparison of Clinical Pregnancy Rates Between Two Protocols, With or Without Low Molecular Weight Heparin Administration Before Frozen Embryo Transfer in Hormonal Replacement Cycles: a Prospective Randomized Controlled Trial Unknown status NCT03120715 Phase 4 estrogen;Low Molecular Weight Heparin;hCG;progesterone
45 The Effect of a Higher Dose of Dehydroepiandrosterone (DHEA) Supplementation on the Number of Oocytes Obtained During IVF in Poor Ovarian Responders Unknown status NCT02357472 Phase 4 dehydroepiandrosterone
46 Intrauterine Injection of Human Chorionic Gonadotropin Before Embryo Transfer in Women With Previous IVF Failure Unknown status NCT02329197 Phase 4 Human Chorionic Gonadotropin (HCG)
47 Corifollitropin Alfa (Elonva) Versus Follitropin Beta in High Responders: A Randomized Controlled Trial Unknown status NCT02471677 Phase 4 Elonva;Puregon
48 Timing of Human Chorionic Gonadotropin Administration in Intrauterine Insemination Cycles Unknown status NCT02330705 Phase 4 HCG
49 Effect of Endometrial Injury Before Frozen Embryo Transfer on Pregnancy Rate Unknown status NCT03220503 Phase 4
50 An Innovative Controlled Ovarian Hyperstimulation (COH) Protocol That Combines Large Oocyte Availability and Physiologic Estrogenic Environment for Good Prognosis In Vitro Fertilization and Embryo Transfer (IVF-ET) Patients Unknown status NCT02892942 Phase 4 Gonal-F®;Cetrotide®;Cetrotide®

Search NIH Clinical Center for Infertility

Inferred drug relations via UMLS 71 / NDF-RT 51 :


2-Bromoergocryptine Mesylate
Bromocriptine
Follicle Stimulating Hormone
Follitropin Alfa
follitropin beta
Leuprolide
Leuprolide Acetate
Sermorelin
Sermorelin Acetate

Cochrane evidence based reviews: infertility

Genetic Tests for Infertility

Genetic tests related to Infertility:

# Genetic test Affiliating Genes
1 Infertility 29

Anatomical Context for Infertility

MalaCards organs/tissues related to Infertility:

40
Ovary, Testis, Uterus, Pituitary, Testes, Thyroid, Bone Marrow

Publications for Infertility

Articles related to Infertility:

(show top 50) (show all 30234)
# Title Authors PMID Year
1
Male Infertility. 61 42
33200633 2021
2
Development of a Dynamic Diagnosis Grading System for Infertility Using Machine Learning. 61 42
33165608 2020
3
Considerations on the restriction of Assisted Reproductive Technology (ART) due to COVID-19. 42
33317710 2020
4
Individualized high-dose cabergoline therapy for hyperprolactinemic infertility in women with micro- and macroprolactinomas. 54 61
20357175 2010
5
FSH receptor, KL1/2, P450, and PAPP genes in granulosa-lutein cells from in vitro fertilization patients show a different expression pattern depending on the infertility diagnosis. 54 61
19342032 2010
6
A 46, XX SRY - negative man with infertility, and co-existing with chronic autoimmune thyroiditis. 61 54
20170343 2010
7
Comparison of mild stimulation and conventional stimulation in ART outcome. 61 54
19834718 2010
8
Expression of macrophage migration inhibitory factor in human endometriosis: relation to disease stage, menstrual cycle and infertility. 61 54
20492386 2010
9
Evaluation of the leptin receptor in human spermatozoa. 61 54
20178606 2010
10
Identification and in vitro characterization of follicle stimulating hormone (FSH) receptor variants associated with abnormal ovarian response to FSH. 54 61
20061434 2010
11
A common haplotype of protamine 1 and 2 genes is associated with higher sperm counts. 61 54
19863670 2010
12
Predictive factors for pregnancy after intrauterine insemination (IUI): an analysis of 1038 cycles and a review of the literature. 54 61
18996517 2010
13
HOXA-10 expression in the mid-secretory endometrium of infertile patients with either endometriosis, uterine fibromas or unexplained infertility. 61 54
19736237 2009
14
Changes in serum cortisol and prolactin associated with acupuncture during controlled ovarian hyperstimulation in women undergoing in vitro fertilization-embryo transfer treatment. 54 61
19118825 2009
15
Experimental immunological infertility effect of anti-GAPDH-2 antibodies on the fertility of female mice. 61 54
18980760 2009
16
Male infertility and the involvement of the X chromosome. 61 54
19515807 2009
17
Absence of the exon 1 coding sequence of the androgen receptor gene associated with teratozoospermia in a Brazilian population. 61 54
19937586 2009
18
RETRACTED: Clomiphene citrate or aromatase inhibitors for superovulation in women with unexplained infertility undergoing intrauterine insemination: a prospective randomized trial. 54 61
18692823 2009
19
Association of CYP1A1 and glutathione S-transferase polymorphisms with male factor infertility. 61 54
18774560 2009
20
Leukemia inhibitory factor and interleukin-11: critical regulators in the establishment of pregnancy. 54 61
19647472 2009
21
The role of prolactin- and endometriosis-associated infertility. 61 54
19624865 2009
22
Estrogen receptor beta gene mutations in Indian infertile men. 61 54
19509112 2009
23
Aromatase inhibitors for ovulation and pregnancy in polycystic ovary syndrome. 61 54
19584394 2009
24
Length of androgen receptor-CAG repeats in fertile and infertile Egyptian men. 61 54
19168451 2009
25
Disturbances in the LIF pathway in the endometrium among women with unexplained infertility. 61 54
18684446 2009
26
The cystic fibrosis transmembrane conductance regulator in reproductive health and disease. 61 54
19015188 2009
27
Acrosin antibodies and infertility. I. Detection of antibodies towards proacrosin/acrosin in women consulting for infertility and evaluation of their effects upon the sperm protease activities. 61 54
18439585 2009
28
Is aromatase expression in the endometrium the cause of endometriosis and related infertility? 61 54
19340622 2009
29
Peritoneal fluid and serum leptin concentrations in women with primary infertility. 61 54
18665375 2009
30
Spermatogenesis in a man with complete deletion of USP9Y. 54 61
19246359 2009
31
CA repeat and RsaI polymorphisms in ERbeta gene are not associated with infertility in Indian men. 61 54
17916182 2009
32
Leukaemia inhibitory factor (LIF) gene mutations in women diagnosed with unexplained infertility and endometriosis have a negative impact on the IVF outcome. A pilot study. 61 54
19545488 2009
33
Inactivating mutations of luteinizing hormone beta-subunit or luteinizing hormone receptor cause oligo-amenorrhea and infertility in women. 54 61
19129711 2009
34
Pregnancy outcome after ovulation induction with aromatase inhibitors or clomiphene citrate in unexplained infertility. 61 54
19089782 2009
35
First trimester screening for Down's syndrome after assisted reproductive technology: non-male factor infertility is associated with elevated free beta-human chorionic gonadotropin levels at 10-14 weeks of gestation. 54 61
18164000 2008
36
Glutathione S-transferase theta 1 expressed in granulosa cells as a biomarker for oocyte quality in age-related infertility. 54 61
17919612 2008
37
Status of serum leptin levels in females with infertility. 54 61
18946565 2008
38
A relationship between increased peritoneal leptin levels and infertility in endometriosis. 54 61
18958774 2008
39
Genetic investigations of CFTR mutations in congenital absence of vas deferens, uterus, and vagina as a cause of infertility. 61 54
18567645 2008
40
Recombinant HCG for triggering ovulation increases the rate of mature oocytes in women treated for ICSI. 54 61
18925430 2008
41
A new LH receptor splice mutation responsible for male hypogonadism with subnormal sperm production in the propositus, and infertility with regular cycles in an affected sister. 61 54
18508780 2008
42
Factors affecting live birth rate in intrauterine insemination cycles with recombinant gonadotrophin stimulation. 61 54
18681993 2008
43
The AZF proteins. 54 61
18462373 2008
44
Treatment of unexplained infertility with aromatase inhibitors or clomiphene citrate: a systematic review and meta-analysis. 61 54
18559123 2008
45
Purification and characterization of biologically active recombinant human Eppin expressed in Escherichia coli. 54 61
18466682 2008
46
A 31-year-old woman with infertility and polycystic ovaries diagnosed with non-classic congenital adrenal hyperplasia due to a novel CYP21 mutation. 61 54
18362511 2008
47
Aromatase inhibitors for infertility in polycystic ovary syndrome. The beginning or the end of a new era? 61 54
18275882 2008
48
Molecular pathology of the FSH receptor: new insights into FSH physiology. 61 54
18248882 2008
49
A386G transition in DAZL gene is not associated with spermatogenic failure in Tamil Nadu, South India. 54 61
20300286 2008
50
Clinical manifestations of impaired GnRH neuron development and function. 61 54
18253056 2008

Variations for Infertility

ClinVar genetic disease variations for Infertility:

6
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 NPHP4 NM_015102.5(NPHP4):c.2044C>T (p.Arg682Ter) SNV Likely pathogenic 3401 rs137852920 1:5964776-5964776 1:5904716-5904716
2 MYO6 NM_004999.4(MYO6):c.3176G>C (p.Arg1059Thr) SNV Uncertain significance 45153 rs202214380 6:76608128-76608128 6:75898411-75898411
3 POLR2C NM_032940.3(POLR2C):c.545T>C (p.Val182Ala) SNV Uncertain significance 872981

Copy number variations for Infertility from CNVD:

7 (show all 50)
# CNVD ID Chromosome Start End Type Gene Symbol CNVD Disease
1 102258 16 51200000 65200000 Indels Infertility
2 116518 17 67628755 67634155 Duplication SOX9 Infertility
3 118010 17 7505821 7531588 Mutation TP53 Infertility
4 119328 18 116099694 116225676 Deletion MET Infertility
5 153448 20 37100000 41100000 Indels Infertility
6 161303 22 18155933 18222462 Copy number GNB1L Infertility
7 211351 6 32593131 32665540 Copy number HLA-DRB5 Infertility
8 212278 6 3674895 32665540 Copy number HLA-DRB1 Infertility
9 212443 6 3813334 32742444 Copy number HLA-DQB1 Infertility
10 261402 X 19200000 29400000 Indels Infertility
11 266740 Y 1 57772954 Deletion infertility
12 266746 Y 1 57772954 Microdeletion infertility
13 266750 Y 1 57772954 Microdeletion infertility
14 266796 Y 11300000 27200000 Deletion AZF1 infertility
15 266823 Y 11300000 27200000 Microdeletion Infertility
16 266826 Y 11300000 27200000 Microdeletion AZF1 infertility
17 266827 Y 11300000 27200000 Microdeletion infertility
18 266828 Y 11300000 27200000 Microdeletion infertility
19 266829 Y 11300000 27200000 Microdeletion BPY2 infertility
20 266830 Y 11300000 27200000 Microdeletion CDY1 infertility
21 266831 Y 11300000 27200000 Microdeletion CDY1 infertility
22 266833 7 116907252 117095954 Microdeletion CFTR Infertility
23 266835 Y 11300000 27200000 Microdeletion CSPG4P1Y infertility
24 266836 Y 11300000 27200000 Microdeletion DAZ1 infertility
25 266837 Y 11300000 27200000 Microdeletion DDX3Y infertility
26 266838 Y 11300000 27200000 Microdeletion infertility
27 266840 Y 11300000 27200000 Microdeletion infertility
28 266841 Y 11300000 27200000 Microdeletion infertility
29 266842 Y 11300000 27200000 Microdeletion RBMY1A1 infertility
30 266843 Y 11300000 27200000 Microdeletion USP9Y infertility
31 266967 Y 174481503 174538309 Microdeletion AZF1 infertility
32 266975 Y 174481503 174538309 Microdeletions AZF1 infertility
33 266976 Y 174481503 174538309 Microdeletions AZF1 infertility
34 267088 Y 23407118 25740308 Copy number TTTY17A Infertility
35 267093 Y 23539797 25607639 Copy number BPY2 Infertility
36 267094 Y 23539797 25607639 Copy number BPY2 Infertility
37 267098 Y 23539797 25607639 Copy number BPY2B Infertility
38 267102 Y 23539797 25607639 Copy number BPY2C Infertility
39 267113 Y 23684889 23754627 Copy number DAZ1 Infertility
40 267116 Y 23684889 23754627 Copy number DAZ1 Infertility
41 267124 Y 23684889 25462570 Copy number DAZ2 Infertility
42 267128 Y 23684889 25462570 Copy number DAZ4 Infertility
43 267135 Y 23775009 25462570 Copy number DAZ3 Infertility
44 267150 Y 24492261 26288923 Copy number TTTY3 Infertility
45 267152 Y 24600763 26180436 Copy number CDY1 Infertility
46 267156 Y 24738968 26042240 Copy number CSPG4P1Y Infertility
47 267182 Y 25125736 25162560 Copy number TTTY4 Infertility
48 267526 mtDNA 1 16569 Mutation MT-ATP6 Infertility
49 267527 mtDNA 1 16569 Mutation MT-CYB Infertility
50 267528 1 183532144 183553084 Mutation IVNS1ABP Infertility

Expression for Infertility

Search GEO for disease gene expression data for Infertility.

Pathways for Infertility

Pathways related to Infertility according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.82 NR5A1 LHCGR LHB FSHR FSHB CFTR
2 12.05 LHCGR LHB FSHR FSHB CFTR
3 11.87 LHCGR LHB FSHR FSHB
4
Show member pathways
11.44 ZP3 ZP2 CATSPER2 CATSPER1
5 11.26 LHCGR LHB FSHR FSHB CYP19A1
6 10.98 FSHR FSHB CYP19A1
7 10.82 FSHR FSHB
8 10.73 ZP3 ZP2 NR5A1 LHCGR INHA FSHR
9 10.37 LHCGR LHB FSHR FSHB

GO Terms for Infertility

Cellular components related to Infertility according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 motile cilium GO:0031514 9.33 DNAH1 CATSPER2 CATSPER1
2 CatSper complex GO:0036128 8.96 CATSPER2 CATSPER1
3 egg coat GO:0035805 8.62 ZP3 ZP2

Biological processes related to Infertility according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 cell differentiation GO:0030154 10 NR5A1 INHA DPY19L2 DAZL CATSPER2 CATSPER1
2 spermatogenesis GO:0007283 9.85 FSHR DPY19L2 DAZL CATSPER2 CATSPER1 AURKC
3 sperm capacitation GO:0048240 9.57 CFTR CATSPER2
4 female gamete generation GO:0007292 9.56 FSHR FSHB
5 flagellated sperm motility GO:0030317 9.56 NPHP4 DNAH1 CATSPER2 CATSPER1
6 peptide hormone processing GO:0016486 9.55 LHB FSHB
7 sperm-egg recognition GO:0035036 9.54 CATSPER2 CATSPER1
8 regulation of osteoclast differentiation GO:0045670 9.51 FSHR FSHB
9 female gonad development GO:0008585 9.5 NR5A1 FSHR CYP19A1
10 oocyte development GO:0048599 9.49 ZP3 AURKC
11 Sertoli cell proliferation GO:0060011 9.48 FSHR FSHB
12 ovulation cycle process GO:0022602 9.46 LHCGR FSHR
13 ovarian follicle development GO:0001541 9.46 LHCGR INHA FSHR FSHB
14 follicle-stimulating hormone signaling pathway GO:0042699 9.43 FSHR FSHB
15 progesterone biosynthetic process GO:0006701 9.4 LHB FSHB
16 male gonad development GO:0008584 9.35 NR5A1 LHCGR LHB INHA FSHR
17 hormone-mediated signaling pathway GO:0009755 9.02 NR5A1 LHCGR LHB FSHR FSHB

Molecular functions related to Infertility according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.5 LHB INHA FSHB
2 calcium activated cation channel activity GO:0005227 9.26 CATSPER2 CATSPER1
3 protein-hormone receptor activity GO:0016500 9.16 LHCGR FSHR
4 acrosin binding GO:0032190 8.96 ZP3 ZP2
5 structural constituent of egg coat GO:0035804 8.62 ZP3 ZP2

Sources for Infertility

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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