MCID: INF027
MIFTS: 29

Infiltrative Basal Cell Carcinoma

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Infiltrative Basal Cell Carcinoma

MalaCards integrated aliases for Infiltrative Basal Cell Carcinoma:

Name: Infiltrative Basal Cell Carcinoma 12 15
Skin Infiltrating Basal Cell Carcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4299

Summaries for Infiltrative Basal Cell Carcinoma

MalaCards based summary : Infiltrative Basal Cell Carcinoma, also known as skin infiltrating basal cell carcinoma, is related to basal cell carcinoma and nodular basal cell carcinoma. An important gene associated with Infiltrative Basal Cell Carcinoma is NGFR (Nerve Growth Factor Receptor), and among its related pathways/superpathways are Cytoskeletal Signaling and Keratinization. Affiliated tissues include skin, and related phenotype is integument.

Related Diseases for Infiltrative Basal Cell Carcinoma

Diseases related to Infiltrative Basal Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 195)
# Related Disease Score Top Affiliating Genes
1 basal cell carcinoma 30.7 KRT15 KRT17 KRT20 KRT7 TP53
2 nodular basal cell carcinoma 30.5 KRT15 KRT17
3 actinic keratosis 30.1 KRT17 KRT20 TP53
4 malignant syringoma 30.1 DAND5 KRT15 KRT20 KRT7
5 carcinosarcoma 30.0 KRT7 MME TP53
6 basal cell carcinoma 1 10.6
7 eccrine acrospiroma 10.5 KRT15 KRT17
8 goblet cell carcinoid 10.5 CDH1 KRT20
9 jejunal adenocarcinoma 10.5 KRT20 KRT7
10 chronic cystitis 10.5 KRT20 KRT7
11 ovarian mucinous adenocarcinoma 10.5 KRT20 KRT7
12 bladder adenocarcinoma 10.5 KRT20 KRT7
13 medulloepithelioma 10.5 KRT20 KRT7
14 bile duct adenoma 10.5 KRT20 KRT7
15 appendix disease 10.5 KRT20 KRT7
16 apocrine sweat gland neoplasm 10.5 KRT15 KRT7
17 bowen's disease 10.4 KRT17 KRT7
18 apocrine adenocarcinoma 10.4 AR KRT15
19 bladder papillary transitional cell neoplasm 10.4 KRT20 TP53
20 urinary tract papillary transitional cell benign neoplasm 10.4 KRT20 TP53
21 malignant leydig cell tumor 10.4 KRT7 MME
22 adenomyoma 10.4 KRT7 MME
23 cystic basal cell carcinoma 10.4 KRT20 KRT7
24 vulva squamous cell carcinoma 10.4 KRT17 TP53
25 clear cell papillary renal cell carcinoma 10.4 KRT7 MME
26 corneal abscess 10.4 AR KRT7
27 vulvar sarcoma 10.4 AR KRT7
28 seminal vesicle adenocarcinoma 10.4 KRT20 KRT7
29 transverse colon cancer 10.4 KRT20 KRT7
30 appendix adenocarcinoma 10.4 KRT20 KRT7
31 sarcomatoid renal cell carcinoma 10.4 CDH1 TP53
32 vulvar disease 10.4 KRT7 TP53
33 female reproductive endometrioid cancer 10.4 KRT7 TP53
34 nasal cavity adenocarcinoma 10.4 KRT7 TP53
35 basal cell carcinoma, infundibulocystic 10.4 KRT17 KRT20
36 bladder carcinoma in situ 10.4 KRT7 TP53
37 glandular cystitis 10.3 KRT20 KRT7
38 cervical carcinosarcoma 10.3 MME TP53
39 papillary transitional carcinoma 10.3 KRT20 KRT7
40 spiradenoma 10.3 KRT7 TP53
41 eyelid carcinoma 10.3 KRT20 KRT7
42 krukenberg carcinoma 10.3 KRT20 KRT7
43 bartholin's gland disease 10.3 AR TP53
44 lung acinar adenocarcinoma 10.3 KRT20 KRT7
45 pancreatic serous cystadenoma 10.3 CEACAM5 KRT7
46 adenoid basal cell carcinoma 10.3 CEACAM5 KRT7
47 eccrine adenocarcinoma 10.3 CEACAM5 KRT7
48 ampulla of vater adenocarcinoma 10.3 KRT17 KRT20 KRT7
49 ovarian lymphoma 10.3 CEACAM5 MME
50 cervical adenoma malignum 10.3 KRT7 MME

Graphical network of the top 20 diseases related to Infiltrative Basal Cell Carcinoma:



Diseases related to Infiltrative Basal Cell Carcinoma

Symptoms & Phenotypes for Infiltrative Basal Cell Carcinoma

MGI Mouse Phenotypes related to Infiltrative Basal Cell Carcinoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.23 AR CDH1 CDH3 KRT17 MLANA MME

Drugs & Therapeutics for Infiltrative Basal Cell Carcinoma

Search Clinical Trials , NIH Clinical Center for Infiltrative Basal Cell Carcinoma

Genetic Tests for Infiltrative Basal Cell Carcinoma

Anatomical Context for Infiltrative Basal Cell Carcinoma

MalaCards organs/tissues related to Infiltrative Basal Cell Carcinoma:

42
Skin

Publications for Infiltrative Basal Cell Carcinoma

Articles related to Infiltrative Basal Cell Carcinoma:

(show all 17)
# Title Authors Year
1
Tissue-sparing properties of Mohs micrographic surgery for infiltrative basal cell carcinoma. ( 30710602 )
2019
2
Infiltrative basal cell carcinoma mimicking tinea corporis. ( 29634889 )
2018
3
Combined carbon dioxide laser with photodynamic therapy for the treatment of nodular and infiltrative basal cell carcinoma. ( 29050450 )
2017
4
Inoperable infiltrative basal cell carcinoma successfully treated with vismodegib. ( 28631369 )
2017
5
Pulmonary metastases in a patient with an aggressive infiltrative basal cell carcinoma of the scalp. ( 28251897 )
2017
6
Girl with small ulcer of the nose: Infiltrative basal cell carcinoma. ( 25336006 )
2014
7
An Unusual Infiltrative Basal Cell Carcinoma With Osteoclastic Stromal Changes Mimicking Carcinosarcoma: A Case Report. ( 24786580 )
2014
8
Expression of p75 neurotrophin receptor in desmoplastic trichoepithelioma, infiltrative basal cell carcinoma, and microcystic adnexal carcinoma. ( 23598854 )
2013
9
Epiluminescence microscopy (dermoscopy) versus visual inspection during Mohs microscopic surgery of infiltrative basal cell carcinoma. ( 22676346 )
2012
10
Fibroblast-activation protein: a single marker that confidently differentiates morpheaform/infiltrative basal cell carcinoma from desmoplastic trichoepithelioma. ( 20711172 )
2010
11
Panel vs. single marker for discriminating desmoplastic trichoepithelioma from morpheaform/infiltrative basal cell carcinoma. ( 19208081 )
2009
12
Does the panel of cytokeratin 20 and androgen receptor antibodies differentiate desmoplastic trichoepithelioma from morpheaform/infiltrative basal cell carcinoma? ( 18190441 )
2008
13
Actin expression in purely nodular versus nodular-infiltrative basal cell carcinoma. ( 12680952 )
2003
14
E-cadherin expression is frequently reduced in infiltrative basal cell carcinoma. ( 11211800 )
2000
15
Infiltrative basal cell carcinoma occurring in sites of biopsy-proven nodular basal cell carcinoma. ( 9826167 )
1998
16
Duplicitous growth of infiltrative basal cell carcinoma: Analysis of clinically undetected tumor extent in a paired case-control study. ( 8646468 )
1996
17
Infiltrative basal cell carcinoma: a nonsclerosing subtype. ( 3734235 )
1986

Variations for Infiltrative Basal Cell Carcinoma

Cosmic variations for Infiltrative Basal Cell Carcinoma:

9 (show top 50) (show all 687)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM3691166 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.2084C>T p.P695L 16:72958062-72958062 0
2 COSM6926860 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.5825G>A p.G1942E 16:72796857-72796857 0
3 COSM6926861 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.1655C>T p.S552F 16:72958491-72958491 0
4 COSM6969201 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.11050G>A p.D3684N 16:72787226-72787226 0
5 COSM6953811 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.1991C>T p.S664F 16:72958155-72958155 0
6 COSM6926862 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.1261G>A p.G421R 16:72958885-72958885 0
7 COSM6936924 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.10847C>T p.S3616F 16:72787429-72787429 0
8 COSM212945 XPO1 skin,NS,carcinoma,basal cell carcinoma c.782G>A p.R261Q 2:61496985-61496985 0
9 COSM6936922 TSC2 skin,NS,carcinoma,basal cell carcinoma c.2060C>T p.S687F 16:2071897-2071897 0
10 COSM6926855 TSC2 skin,NS,carcinoma,basal cell carcinoma c.679T>A p.C227S 16:2056674-2056674 0
11 COSM6953809 TSC2 skin,NS,carcinoma,basal cell carcinoma c.869C>T p.P290L 16:2058767-2058767 0
12 COSM6912933 TRAF7 skin,NS,carcinoma,basal cell carcinoma c.1802C>T p.T601I 16:2176104-2176104 0
13 COSM6949578 TP63 skin,NS,carcinoma,basal cell carcinoma c.1922C>T p.A641V 3:189894381-189894381 0
14 COSM44097 TP53 skin,NS,carcinoma,basal cell carcinoma c.530C>T p.P177L 17:7675082-7675082 0
15 COSM44071 TP53 skin,NS,carcinoma,basal cell carcinoma c.955A>G p.K319E 17:7673573-7673573 0
16 COSM44096 TP53 skin,NS,carcinoma,basal cell carcinoma c.748C>G p.P250A 17:7674215-7674215 0
17 COSM45751 TP53 skin,NS,carcinoma,basal cell carcinoma c.511G>C p.E171Q 17:7675101-7675101 0
18 COSM10768 TP53 skin,NS,carcinoma,basal cell carcinoma c.535C>T p.H179Y 17:7675077-7675077 0
19 COSM10887 TP53 skin,NS,carcinoma,basal cell carcinoma c.833C>G p.P278R 17:7673787-7673787 0
20 COSM10728 TP53 skin,NS,carcinoma,basal cell carcinoma c.839G>A p.R280K 17:7673781-7673781 0
21 COSM45739 TP53 skin,NS,carcinoma,basal cell carcinoma c.677G>C p.G226A 17:7674286-7674286 0
22 COSM44295 TP53 skin,NS,carcinoma,basal cell carcinoma c.993+1G>A p.? 17:7673534-7673534 0
23 COSM43778 TP53 skin,NS,carcinoma,basal cell carcinoma c.713G>T p.C238F 17:7674250-7674250 0
24 COSM10939 TP53 skin,NS,carcinoma,basal cell carcinoma c.832C>T p.P278S 17:7673788-7673788 0
25 COSM10650 TP53 skin,NS,carcinoma,basal cell carcinoma c.529C>T p.P177S 17:7675083-7675083 0
26 COSM43665 TP53 skin,NS,carcinoma,basal cell carcinoma c.746G>C p.R249T 17:7674217-7674217 0
27 COSM10662 TP53 skin,NS,carcinoma,basal cell carcinoma c.743G>A p.R248Q 17:7674220-7674220 0
28 COSM45774 TP53 skin,NS,carcinoma,basal cell carcinoma c.899C>G p.P300R 17:7673721-7673721 0
29 COSM10749 TP53 skin,NS,carcinoma,basal cell carcinoma c.830G>T p.C277F 17:7673790-7673790 0
30 COSM11449 TP53 skin,NS,carcinoma,basal cell carcinoma c.388C>T p.L130F 17:7675224-7675224 0
31 COSM10660 TP53 skin,NS,carcinoma,basal cell carcinoma c.818G>A p.R273H 17:7673802-7673802 0
32 COSM44068 TP53 skin,NS,carcinoma,basal cell carcinoma c.532C>A p.H178N 17:7675080-7675080 0
33 COSM10771 TP53 skin,NS,carcinoma,basal cell carcinoma c.749C>T p.P250L 17:7674214-7674214 0
34 COSM11152 TP53 skin,NS,carcinoma,basal cell carcinoma c.700T>C p.Y234H 17:7674263-7674263 0
35 COSM43582 TP53 skin,NS,carcinoma,basal cell carcinoma c.454C>T p.P152S 17:7675158-7675158 0
36 COSM45834 TP53 skin,NS,carcinoma,basal cell carcinoma c.409C>A p.L137M 17:7675203-7675203 0
37 COSM10905 TP53 skin,NS,carcinoma,basal cell carcinoma c.451C>T p.P151S 17:7675161-7675161 0
38 COSM10654 TP53 skin,NS,carcinoma,basal cell carcinoma c.637C>T p.R213* 17:7674894-7674894 0
39 COSM45424 TP53 skin,NS,carcinoma,basal cell carcinoma c.781A>T p.S261C 17:7674182-7674182 0
40 COSM10648 TP53 skin,NS,carcinoma,basal cell carcinoma c.524G>A p.R175H 17:7675088-7675088 0
41 COSM6932 TP53 skin,NS,carcinoma,basal cell carcinoma c.733G>A p.G245S 17:7674230-7674230 0
42 COSM10812 TP53 skin,NS,carcinoma,basal cell carcinoma c.722C>T p.S241F 17:7674241-7674241 0
43 COSM10656 TP53 skin,NS,carcinoma,basal cell carcinoma c.742C>T p.R248W 17:7674221-7674221 0
44 COSM10659 TP53 skin,NS,carcinoma,basal cell carcinoma c.817C>T p.R273C 17:7673803-7673803 0
45 COSM10794 TP53 skin,NS,carcinoma,basal cell carcinoma c.796G>A p.G266R 17:7673824-7673824 0
46 COSM44552 TP53 skin,NS,carcinoma,basal cell carcinoma c.509C>T p.T170M 17:7675103-7675103 0
47 COSM10704 TP53 skin,NS,carcinoma,basal cell carcinoma c.844C>T p.R282W 17:7673776-7673776 0
48 COSM10726 TP53 skin,NS,carcinoma,basal cell carcinoma c.856G>A p.E286K 17:7673764-7673764 0
49 COSM6549 TP53 skin,NS,carcinoma,basal cell carcinoma c.743G>T p.R248L 17:7674220-7674220 0
50 COSM45304 TP53 skin,NS,carcinoma,basal cell carcinoma c.375+1G>A p.? 17:7675993-7675993 0

Expression for Infiltrative Basal Cell Carcinoma

Search GEO for disease gene expression data for Infiltrative Basal Cell Carcinoma.

Pathways for Infiltrative Basal Cell Carcinoma

Pathways related to Infiltrative Basal Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 12.05 CDH1 KRT17 KRT20 KRT7
2
Show member pathways
11.91 KRT15 KRT17 KRT20 KRT7
3 11.65 CDH1 CDH17 CDH3 TP53
4 11.63 CDH1 CDH17 CDH3
5
Show member pathways
11.55 CDH1 CDH17 CDH3 TP53
6 11.01 CDH1 CDH17 CDH3 CEACAM5

GO Terms for Infiltrative Basal Cell Carcinoma

Cellular components related to Infiltrative Basal Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intermediate filament GO:0005882 9.46 KRT15 KRT17 KRT20 KRT7
2 cell-cell adherens junction GO:0005913 9.43 CDH1 CDH17 CDH3
3 cell surface GO:0009986 9.17 CDH1 CDH17 CDH3 CEACAM5 FAP FUT4
4 catenin complex GO:0016342 9.13 CDH1 CDH17 CDH3

Biological processes related to Infiltrative Basal Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 apoptotic process GO:0006915 9.92 CEACAM5 FAP KRT20 NGFR TP53
2 cell adhesion GO:0007155 9.89 CDH1 CDH17 CDH3 CEACAM5 FAP
3 homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 9.67 CDH1 CDH17 CDH3 CEACAM5
4 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules GO:0016339 9.58 CDH1 CDH17 CDH3
5 intermediate filament organization GO:0045109 9.51 KRT17 KRT20
6 cell-cell junction assembly GO:0007043 9.5 CDH1 CDH17 CDH3
7 positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 9.48 AR CDH3
8 replicative senescence GO:0090399 9.46 MME TP53
9 cornification GO:0070268 9.46 KRT15 KRT17 KRT20 KRT7
10 positive regulation of execution phase of apoptosis GO:1900119 9.43 FAP TP53
11 adherens junction organization GO:0034332 9.43 CDH1 CDH17 CDH3
12 cell-cell adhesion mediated by cadherin GO:0044331 9.13 CDH1 CDH17 CDH3
13 keratinization GO:0031424 9.02 CDH3 KRT15 KRT17 KRT20 KRT7

Molecular functions related to Infiltrative Basal Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of cytoskeleton GO:0005200 9.33 KRT15 KRT17 KRT20
2 cytoskeletal protein binding GO:0008092 9.13 CDH1 CDH17 CDH3
3 protein homodimerization activity GO:0042803 9.1 CDH1 CDH17 CDH3 CEACAM5 CLEC2A FAP

Sources for Infiltrative Basal Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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