MCID: INF027
MIFTS: 26

Infiltrative Basal Cell Carcinoma

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Infiltrative Basal Cell Carcinoma

MalaCards integrated aliases for Infiltrative Basal Cell Carcinoma:

Name: Infiltrative Basal Cell Carcinoma 12 15
Skin Infiltrating Basal Cell Carcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4299

Summaries for Infiltrative Basal Cell Carcinoma

MalaCards based summary : Infiltrative Basal Cell Carcinoma, also known as skin infiltrating basal cell carcinoma, is related to nodular basal cell carcinoma and basal cell carcinoma. An important gene associated with Infiltrative Basal Cell Carcinoma is NGFR (Nerve Growth Factor Receptor), and among its related pathways/superpathways are Cytoskeletal Signaling and Adhesion. Affiliated tissues include skin.

Related Diseases for Infiltrative Basal Cell Carcinoma

Diseases related to Infiltrative Basal Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 164)
# Related Disease Score Top Affiliating Genes
1 nodular basal cell carcinoma 30.9 KRT15 KRT17
2 basal cell carcinoma 30.3 KRT15 KRT17 KRT20 KRT7 MME
3 malignant syringoma 29.5 DAND5 KRT15 KRT17 KRT20 KRT7
4 basal cell carcinoma, infundibulocystic 10.9 KRT17 KRT20
5 cystic basal cell carcinoma 10.9 KRT20 KRT7
6 vaginal benign neoplasm 10.8 KRT20 KRT7
7 seminal vesicle adenocarcinoma 10.8 KRT20 KRT7
8 transverse colon cancer 10.8 KRT20 KRT7
9 appendix adenocarcinoma 10.8 KRT20 KRT7
10 ovarian large-cell neuroendocrine carcinoma 10.8 KRT20 KRT7
11 vaginal adenoma 10.8 KRT20 KRT7
12 vaginal tubulovillous adenoma 10.8 KRT20 KRT7
13 eyelid neoplasm 10.8 KRT20 KRT7
14 glandular cystitis 10.8 KRT20 KRT7
15 krukenberg carcinoma 10.8 KRT20 KRT7
16 goblet cell carcinoid 10.8 CDH1 KRT20
17 lung acinar adenocarcinoma 10.8 KRT20 KRT7
18 small cell carcinoma of the bladder 10.8 KRT20 KRT7
19 mucinous bronchioloalveolar adenocarcinoma 10.8 KRT20 KRT7
20 hidrocystoma 10.8 KRT15 KRT7
21 intratubular embryonal carcinoma 10.8 KRT20 KRT7
22 ovarian mucinous adenocarcinoma 10.8 KRT20 KRT7
23 apocrine sweat gland neoplasm 10.8 KRT15 KRT7
24 renal pelvis adenocarcinoma 10.7 CDH1 KRT7
25 papillary serous adenocarcinoma 10.7 KRT20 KRT7
26 bladder adenocarcinoma 10.7 KRT20 KRT7
27 jejunal adenocarcinoma 10.7 KRT20 KRT7
28 extrahepatic bile duct adenocarcinoma 10.7 CDH1 MME
29 chronic cystitis 10.7 KRT20 KRT7
30 prostatic acinar adenocarcinoma 10.7 AR KRT20
31 medulloepithelioma 10.7 KRT20 KRT7
32 cervical adenoma malignum 10.7 KRT7 MME
33 glycogen-rich clear cell breast carcinoma 10.7 KRT20 KRT7
34 bowen's disease 10.7 KRT17 KRT7
35 renal pelvis carcinoma 10.7 KRT20 KRT7
36 cervical mucinous adenocarcinoma 10.6 KRT7 MME
37 clear cell papillary renal cell carcinoma 10.6 KRT7 MME
38 appendix cancer 10.6 KRT20 KRT7
39 inverted follicular keratosis 10.6 CLEC2A KRT17
40 mucinous cystadenocarcinoma 10.6 KRT20 KRT7
41 malignant leydig cell tumor 10.6 KRT7 MME
42 oncocytic breast carcinoma 10.6 AR KRT7
43 vulvar sarcoma 10.6 AR KRT7
44 apocrine adenocarcinoma 10.6 AR KRT7
45 endocervical adenocarcinoma 10.6 KRT20 KRT7
46 adenomyoma 10.6 KRT7 MME
47 esophageal adenosquamous carcinoma 10.5 CDH1 CEACAM5
48 breast benign neoplasm 10.5 KRT15 MME
49 breast fibroadenoma 10.5 KRT15 MME NGFR
50 ampulla of vater neoplasm 10.5 KRT17 KRT20 KRT7

Graphical network of the top 20 diseases related to Infiltrative Basal Cell Carcinoma:



Diseases related to Infiltrative Basal Cell Carcinoma

Symptoms & Phenotypes for Infiltrative Basal Cell Carcinoma

Drugs & Therapeutics for Infiltrative Basal Cell Carcinoma

Search Clinical Trials , NIH Clinical Center for Infiltrative Basal Cell Carcinoma

Genetic Tests for Infiltrative Basal Cell Carcinoma

Anatomical Context for Infiltrative Basal Cell Carcinoma

MalaCards organs/tissues related to Infiltrative Basal Cell Carcinoma:

41
Skin

Publications for Infiltrative Basal Cell Carcinoma

Articles related to Infiltrative Basal Cell Carcinoma:

(show all 19)
# Title Authors Year
1
Infiltrative basal cell carcinoma mimicking tinea corporis. ( 29634889 )
2018
2
Combined carbon dioxide laser with photodynamic therapy for the treatment of nodular and infiltrative basal cell carcinoma. ( 29050450 )
2017
3
Inoperable infiltrative basal cell carcinoma successfully treated with vismodegib. ( 28631369 )
2017
4
Pulmonary metastases in a patient with an aggressive infiltrative basal cell carcinoma of the scalp. ( 28251897 )
2017
5
Girl with small ulcer of the nose: Infiltrative basal cell carcinoma. ( 25336006 )
2014
6
An Unusual Infiltrative Basal Cell Carcinoma With Osteoclastic Stromal Changes Mimicking Carcinosarcoma: A Case Report. ( 24786580 )
2014
7
Expression of p75 neurotrophin receptor in desmoplastic trichoepithelioma, infiltrative basal cell carcinoma, and microcystic adnexal carcinoma. ( 23598854 )
2013
8
Orbital invasion by periocular infiltrating Basal cell carcinoma. ( 22861659 )
2012
9
Epiluminescence microscopy (dermoscopy) versus visual inspection during Mohs microscopic surgery of infiltrative basal cell carcinoma. ( 22676346 )
2012
10
Fibroblast-activation protein: a single marker that confidently differentiates morpheaform/infiltrative basal cell carcinoma from desmoplastic trichoepithelioma. ( 20711172 )
2010
11
Micronodular basal cell carcinoma: a distinct subtype? Relationship with nodular and infiltrative basal cell carcinomas. ( 20629826 )
2010
12
Panel vs. single marker for discriminating desmoplastic trichoepithelioma from morpheaform/infiltrative basal cell carcinoma. ( 19208081 )
2009
13
Does the panel of cytokeratin 20 and androgen receptor antibodies differentiate desmoplastic trichoepithelioma from morpheaform/infiltrative basal cell carcinoma? ( 18190441 )
2008
14
Infiltrative basal cell carcinomas presenting as actinic keratosis: implications for clinical practice. ( 18053057 )
2008
15
Actin expression in purely nodular versus nodular-infiltrative basal cell carcinoma. ( 12680952 )
2003
16
E-cadherin expression is frequently reduced in infiltrative basal cell carcinoma. ( 11211800 )
2000
17
Infiltrative basal cell carcinoma occurring in sites of biopsy-proven nodular basal cell carcinoma. ( 9826167 )
1998
18
Duplicitous growth of infiltrative basal cell carcinoma: Analysis of clinically undetected tumor extent in a paired case-control study. ( 8646468 )
1996
19
Infiltrative basal cell carcinoma: a nonsclerosing subtype. ( 3734235 )
1986

Variations for Infiltrative Basal Cell Carcinoma

Cosmic variations for Infiltrative Basal Cell Carcinoma:

9
(show top 50) (show all 687)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM6926860 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.5825G>A p.G1942E 16:72796857-72796857 7
2 COSM6926861 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.1655C>T p.S552F 16:72958491-72958491 7
3 COSM6969201 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.11050G>A p.D3684N 16:72787226-72787226 7
4 COSM6953811 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.1991C>T p.S664F 16:72958155-72958155 7
5 COSM6926862 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.1261G>A p.G421R 16:72958885-72958885 7
6 COSM6936924 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.10847C>T p.S3616F 16:72787429-72787429 7
7 COSM3691166 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.2084C>T p.P695L 16:72958062-72958062 7
8 COSM212945 XPO1 skin,NS,carcinoma,basal cell carcinoma c.782G>A p.R261Q 2:61496985-61496985 7
9 COSM6953809 TSC2 skin,NS,carcinoma,basal cell carcinoma c.869C>T p.P290L 16:2058767-2058767 7
10 COSM6936922 TSC2 skin,NS,carcinoma,basal cell carcinoma c.2060C>T p.S687F 16:2071897-2071897 7
11 COSM6926855 TSC2 skin,NS,carcinoma,basal cell carcinoma c.679T>A p.C227S 16:2056674-2056674 7
12 COSM6912933 TRAF7 skin,NS,carcinoma,basal cell carcinoma c.1802C>T p.T601I 16:2176104-2176104 7
13 COSM6949578 TP63 skin,NS,carcinoma,basal cell carcinoma c.1922C>T p.A641V 3:189894381-189894381 7
14 COSM44071 TP53 skin,NS,carcinoma,basal cell carcinoma c.955A>G p.K319E 17:7673573-7673573 7
15 COSM44097 TP53 skin,NS,carcinoma,basal cell carcinoma c.530C>T p.P177L 17:7675082-7675082 7
16 COSM44096 TP53 skin,NS,carcinoma,basal cell carcinoma c.748C>G p.P250A 17:7674215-7674215 7
17 COSM10728 TP53 skin,NS,carcinoma,basal cell carcinoma c.839G>A p.R280K 17:7673781-7673781 7
18 COSM45169 TP53 skin,NS,carcinoma,basal cell carcinoma c.326T>C p.F109S 17:7676043-7676043 7
19 COSM43842 TP53 skin,NS,carcinoma,basal cell carcinoma c.770T>C p.L257P 17:7674193-7674193 7
20 COSM43695 TP53 skin,NS,carcinoma,basal cell carcinoma c.748C>T p.P250S 17:7674215-7674215 7
21 COSM10988 TP53 skin,NS,carcinoma,basal cell carcinoma c.772G>A p.E258K 17:7674191-7674191 7
22 COSM45739 TP53 skin,NS,carcinoma,basal cell carcinoma c.677G>C p.G226A 17:7674286-7674286 7
23 COSM44295 TP53 skin,NS,carcinoma,basal cell carcinoma c.993+1G>A p.? 17:7673534-7673534 7
24 COSM43778 TP53 skin,NS,carcinoma,basal cell carcinoma c.713G>T p.C238F 17:7674250-7674250 7
25 COSM10939 TP53 skin,NS,carcinoma,basal cell carcinoma c.832C>T p.P278S 17:7673788-7673788 7
26 COSM10650 TP53 skin,NS,carcinoma,basal cell carcinoma c.529C>T p.P177S 17:7675083-7675083 7
27 COSM43665 TP53 skin,NS,carcinoma,basal cell carcinoma c.746G>C p.R249T 17:7674217-7674217 7
28 COSM10662 TP53 skin,NS,carcinoma,basal cell carcinoma c.743G>A p.R248Q 17:7674220-7674220 7
29 COSM45774 TP53 skin,NS,carcinoma,basal cell carcinoma c.899C>G p.P300R 17:7673721-7673721 7
30 COSM10749 TP53 skin,NS,carcinoma,basal cell carcinoma c.830G>T p.C277F 17:7673790-7673790 7
31 COSM11449 TP53 skin,NS,carcinoma,basal cell carcinoma c.388C>T p.L130F 17:7675224-7675224 7
32 COSM10660 TP53 skin,NS,carcinoma,basal cell carcinoma c.818G>A p.R273H 17:7673802-7673802 7
33 COSM10771 TP53 skin,NS,carcinoma,basal cell carcinoma c.749C>T p.P250L 17:7674214-7674214 7
34 COSM44068 TP53 skin,NS,carcinoma,basal cell carcinoma c.532C>A p.H178N 17:7675080-7675080 7
35 COSM11152 TP53 skin,NS,carcinoma,basal cell carcinoma c.700T>C p.Y234H 17:7674263-7674263 7
36 COSM43582 TP53 skin,NS,carcinoma,basal cell carcinoma c.454C>T p.P152S 17:7675158-7675158 7
37 COSM10768 TP53 skin,NS,carcinoma,basal cell carcinoma c.535C>T p.H179Y 17:7675077-7675077 7
38 COSM45834 TP53 skin,NS,carcinoma,basal cell carcinoma c.409C>A p.L137M 17:7675203-7675203 7
39 COSM10905 TP53 skin,NS,carcinoma,basal cell carcinoma c.451C>T p.P151S 17:7675161-7675161 7
40 COSM10654 TP53 skin,NS,carcinoma,basal cell carcinoma c.637C>T p.R213* 17:7674894-7674894 7
41 COSM6932 TP53 skin,NS,carcinoma,basal cell carcinoma c.733G>A p.G245S 17:7674230-7674230 7
42 COSM10648 TP53 skin,NS,carcinoma,basal cell carcinoma c.524G>A p.R175H 17:7675088-7675088 7
43 COSM45424 TP53 skin,NS,carcinoma,basal cell carcinoma c.781A>T p.S261C 17:7674182-7674182 7
44 COSM10812 TP53 skin,NS,carcinoma,basal cell carcinoma c.722C>T p.S241F 17:7674241-7674241 7
45 COSM10656 TP53 skin,NS,carcinoma,basal cell carcinoma c.742C>T p.R248W 17:7674221-7674221 7
46 COSM10659 TP53 skin,NS,carcinoma,basal cell carcinoma c.817C>T p.R273C 17:7673803-7673803 7
47 COSM10794 TP53 skin,NS,carcinoma,basal cell carcinoma c.796G>A p.G266R 17:7673824-7673824 7
48 COSM44552 TP53 skin,NS,carcinoma,basal cell carcinoma c.509C>T p.T170M 17:7675103-7675103 7
49 COSM10704 TP53 skin,NS,carcinoma,basal cell carcinoma c.844C>T p.R282W 17:7673776-7673776 7
50 COSM10726 TP53 skin,NS,carcinoma,basal cell carcinoma c.856G>A p.E286K 17:7673764-7673764 7

Expression for Infiltrative Basal Cell Carcinoma

Search GEO for disease gene expression data for Infiltrative Basal Cell Carcinoma.

Pathways for Infiltrative Basal Cell Carcinoma

Pathways related to Infiltrative Basal Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.75 CDH1 KRT17 KRT20 KRT7
2 11.42 CDH1 CDH17 CEACAM5
3
Show member pathways
11.38 KRT15 KRT17 KRT20 KRT7

GO Terms for Infiltrative Basal Cell Carcinoma

Cellular components related to Infiltrative Basal Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.35 CDH1 CDH17 FAP FUT4 NGFR
2 intermediate filament GO:0005882 8.92 KRT15 KRT17 KRT20 KRT7

Biological processes related to Infiltrative Basal Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratinization GO:0031424 9.26 KRT15 KRT17 KRT20 KRT7
2 intermediate filament organization GO:0045109 9.16 KRT17 KRT20
3 cornification GO:0070268 8.92 KRT15 KRT17 KRT20 KRT7

Molecular functions related to Infiltrative Basal Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of cytoskeleton GO:0005200 8.8 KRT15 KRT17 KRT20

Sources for Infiltrative Basal Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....