MCID: INF027
MIFTS: 34

Infiltrative Basal Cell Carcinoma

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Infiltrative Basal Cell Carcinoma

MalaCards integrated aliases for Infiltrative Basal Cell Carcinoma:

Name: Infiltrative Basal Cell Carcinoma 12 15
Skin Infiltrating Basal Cell Carcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4299

Summaries for Infiltrative Basal Cell Carcinoma

MalaCards based summary : Infiltrative Basal Cell Carcinoma, also known as skin infiltrating basal cell carcinoma, is related to basal cell carcinoma and malignant syringoma. An important gene associated with Infiltrative Basal Cell Carcinoma is KRT20 (Keratin 20), and among its related pathways/superpathways are Keratinization and Estrogen signaling pathway (KEGG). Affiliated tissues include skin, kidney and liver, and related phenotypes are Decreased Sindbis virus (SIN) capsid and autophagosome LC3 protein colocalization and Decreased Sindbis virus (SIN) capsid and autophagosome LC3 protein colocalization

Related Diseases for Infiltrative Basal Cell Carcinoma

Diseases related to Infiltrative Basal Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 31)
# Related Disease Score Top Affiliating Genes
1 basal cell carcinoma 30.8 KRT20 KRT17 KRT15
2 malignant syringoma 30.2 KRT20 KRT15
3 gastrointestinal ulceration, recurrent, with dysfunctional platelets 10.2
4 skin carcinoma 10.2
5 eccrine sweat gland cancer 10.1 KRT20 KRT15
6 sweat gland cancer 10.1 KRT20 KRT15
7 squamous papillomatosis 10.1 KRT20 KRT15
8 cystic basal cell carcinoma 10.1 KRT20 KRT15
9 clear cell basal cell carcinoma 10.1 KRT20 KRT17
10 peritoneal serous adenocarcinoma 10.1 KRT20 KRT17
11 tinea corporis 10.0
12 carcinosarcoma 10.0
13 nodular basal cell carcinoma 10.0
14 dermatophytosis 10.0
15 48,xyyy 10.0
16 follicular infundibulum tumor 10.0 KRT17 KRT15
17 borst-jadassohn intraepidermal carcinoma 10.0 KRT20 KRT17
18 basaloid squamous cell carcinoma 10.0 KRT20 KRT17
19 eccrine acrospiroma 10.0 KRT17 KRT15
20 eccrine sweat gland neoplasm 10.0 KRT17 KRT15
21 polycystic liver disease 1 with or without kidney cysts 10.0 KRT20 KRT17
22 ampulla of vater adenocarcinoma 10.0 KRT20 KRT17
23 eccrine papillary adenoma 10.0 KRT17 KRT15
24 hair follicle neoplasm 10.0 KRT17 KRT15
25 breast fibroadenoma 9.9 NGFR KRT15
26 pilomatrixoma 9.9 KRT17 KRT15
27 keratoacanthoma 9.9 KRT17 KRT15
28 ampulla of vater cancer 9.9 KRT20 KRT17
29 morpheaform basal cell carcinoma 9.8 KRT20 KRT17 KRT15
30 actinic keratosis 9.8 KRT20 KRT17
31 epidermolysis bullosa simplex 9.7 KRT17 KRT15

Graphical network of the top 20 diseases related to Infiltrative Basal Cell Carcinoma:



Diseases related to Infiltrative Basal Cell Carcinoma

Symptoms & Phenotypes for Infiltrative Basal Cell Carcinoma

GenomeRNAi Phenotypes related to Infiltrative Basal Cell Carcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased Sindbis virus (SIN) capsid and autophagosome LC3 protein colocalization GR00242-A-1 9.4 KRT15 P2RX5 P2RY4
2 Decreased Sindbis virus (SIN) capsid and autophagosome LC3 protein colocalization GR00242-A-2 9.4 KRT15 P2RX5 P2RY4
3 Decreased mitophagy mCherry-Parkin protein expression after carbonyl cyanide m-chlorphenylhydrazone (CCCP) stimulation GR00242-A-4 9.13 KRT15 P2RX5 P2RY4

MGI Mouse Phenotypes related to Infiltrative Basal Cell Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.02 EHF KRT15 KRT17 NGFR P2RY4

Drugs & Therapeutics for Infiltrative Basal Cell Carcinoma

Search Clinical Trials , NIH Clinical Center for Infiltrative Basal Cell Carcinoma

Genetic Tests for Infiltrative Basal Cell Carcinoma

Anatomical Context for Infiltrative Basal Cell Carcinoma

MalaCards organs/tissues related to Infiltrative Basal Cell Carcinoma:

40
Skin, Kidney, Liver, Breast

Publications for Infiltrative Basal Cell Carcinoma

Articles related to Infiltrative Basal Cell Carcinoma:

(show all 47)
# Title Authors PMID Year
1
Angulated small nests and cords: Key diagnostic histopathologic features of infiltrative basal cell carcinoma can be identified using integrated reflectance confocal microscopy-optical coherence tomography. 61
32989842 2021
2
Excision margin of T3 basal cell carcinoma in maxillofacial area: A retrospective cohort study of Asians. 61
33274605 2020
3
Basal cell carcinoma stroma as a mimicker of lymphatic invasion: A case report. 61
32477557 2020
4
Metastatic basal cell carcinoma with evidence of intravascular invasion: A case report. 61
32117571 2020
5
Clinical and Dermoscopic Factors for the Identification of Aggressive Histologic Subtypes of Basal Cell Carcinoma. 61
33680953 2020
6
What are the ethical and legal considerations when your patient refuses the standard of care? 61
31553860 2019
7
Tissue-sparing properties of Mohs micrographic surgery for infiltrative basal cell carcinoma. 61
30710602 2019
8
Denial of Illness in a Patient with Infiltrative Basal Cell Carcinoma. 61
31627795 2019
9
Two-stage rapid exenteration reconstruction to allow early radiation therapy for an aggressive orbital cancer. 61
28474158 2018
10
Infiltrative basal cell carcinoma mimicking tinea corporis. 61
29634889 2018
11
Loss of epithelial cell adhesion molecule (EpCAM) in infiltrative basal cell carcinoma. 61
31938125 2018
12
Combined carbon dioxide laser with photodynamic therapy for the treatment of nodular and infiltrative basal cell carcinoma. 61
29050450 2017
13
Microcystic Adnexal Carcinoma: A Review of the Literature. 61
28654578 2017
14
Inoperable infiltrative basal cell carcinoma successfully treated with vismodegib. 61
28631369 2017
15
[Mohs micrographic surgery: 27 year experience in the Northeast of Mexico]. 61
27955856 2017
16
Pulmonary metastases in a patient with an aggressive infiltrative basal cell carcinoma of the scalp. 61
28251897 2017
17
Basal cell carcinoma arising in a congenital melanocytic naevus in an adult. 61
28193642 2017
18
Non-melanoma skin cancer: United Kingdom National Multidisciplinary Guidelines. 61
27841126 2016
19
Description of Patients Undergoing Mohs Surgery in Spain: Initial Report on Data From the Spanish Registry of Mohs Surgery (REGESMOHS). 61
26028578 2015
20
An unusual infiltrative basal cell carcinoma with osteoclastic stromal changes mimicking carcinosarcoma: a case report. 61
24786580 2015
21
Girl with small ulcer of the nose: infiltrative basal cell carcinoma. 61
25336006 2014
22
Expression of p75 neurotrophin receptor in desmoplastic trichoepithelioma, infiltrative basal cell carcinoma, and microcystic adnexal carcinoma. 61
23598854 2013
23
[Surgical treatment of malignant eyelid tumors]. 61
23745328 2013
24
Diagnosis and treatment of tracheal basal cell carcinoma in a Maine coon and long-term outcome. 61
22611213 2012
25
Epiluminescence microscopy (dermoscopy) versus visual inspection during Mohs microscopic surgery of infiltrative basal cell carcinoma. 61
22676346 2012
26
[Basal cell carcinoma of unusual site]. 61
21349386 2011
27
Fibroblast-activation protein: a single marker that confidently differentiates morpheaform/infiltrative basal cell carcinoma from desmoplastic trichoepithelioma. 61
20711172 2010
28
[Infiltrative basal cell carcinoma presenting as chronic leg ulcer]. 61
20227566 2010
29
Imiquimod-induced vitiligo after treatment of nodular basal cell carcinoma. 61
19586497 2009
30
Panel vs. single marker for discriminating desmoplastic trichoepithelioma from morpheaform/infiltrative basal cell carcinoma. 61
19208081 2009
31
Metastatic basal cell carcinoma exhibits reduced actin expression. 61
18223552 2008
32
Does the panel of cytokeratin 20 and androgen receptor antibodies differentiate desmoplastic trichoepithelioma from morpheaform/infiltrative basal cell carcinoma? 61
18190441 2008
33
Microcystic adnexal carcinoma: an immunohistochemical reappraisal. 61
18065959 2008
34
The switch flap in eyelid reconstruction. 61
18097963 2007
35
Multimodal confocal microscopy for diagnosing nonmelanoma skin cancers. 61
17960751 2007
36
[Basal cell carcinoma of the first toenail]. 61
17978714 2007
37
[Treatment results after surgery for basal cell carcinomas of the head and neck region taking into consideration various reconstruction techniques]. 61
15719264 2005
38
Cutaneous spindle cell carcinoma following basal cell carcinoma. 61
15677971 2005
39
Clinical significance of telomerase activity in basal cell carcinomas and in tumour-free surgical margins. 61
14532981 2003
40
Actin expression in purely nodular versus nodular-infiltrative basal cell carcinoma. 61
12680952 2003
41
E-cadherin expression is frequently reduced in infiltrative basal cell carcinoma. 61
11211800 2000
42
Value of p53 protein in biological behavior of basal cell carcinoma and in normal epithelia adjacent to carcinomas. 61
11173659 2000
43
Infiltrative basal cell carcinoma occurring in sites of biopsy-proven nodular basal cell carcinoma. 61
9826167 1998
44
Duplicitous growth of infiltrative basal cell carcinoma: Analysis of clinically undetected tumor extent in a paired case-control study. 61
8646468 1996
45
Differential patterns of placental and epithelial cadherin expression in basal cell carcinoma and in the epidermis overlying tumours. 61
7640213 1995
46
Infiltrative basal cell carcinoma: a nonsclerosing subtype. 61
3734235 1986
47
Results of cryotherapy for eyelid malignancies. 61
6696028 1984

Variations for Infiltrative Basal Cell Carcinoma

Cosmic variations for Infiltrative Basal Cell Carcinoma:

9 (show top 50) (show all 3424)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM84510986 ZNF276 skin,NS,carcinoma,basal cell carcinoma c.*940C>T p.? 16:89739186-89739186 3
2 COSM149268805 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.1261G>A p.G421R 16:72958885-72958885 3
3 COSM87274302 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.1655C>T p.S552F 16:72958491-72958491 3
4 COSM87270496 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.10847C>T p.S3616F 16:72787429-72787429 3
5 COSM149259613 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.10847C>T p.S3616F 16:72787429-72787429 3
6 COSM149268792 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.5825G>A p.G1942E 16:72796857-72796857 3
7 COSM87274307 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.1261G>A p.G421R 16:72958885-72958885 3
8 COSM149268800 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.1655C>T p.S552F 16:72958491-72958491 3
9 COSM87273325 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.2084C>T p.P695L 16:72958062-72958062 3
10 COSM149304906 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.1991C>T p.S664F 16:72958155-72958155 3
11 COSM87296537 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.11050G>A p.D3684N 16:72787226-72787226 3
12 COSM102023150 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.-23-7526C>T p.? 16:72958491-72958491 3
13 COSM102023155 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.-23-7920G>A p.? 16:72958885-72958885 3
14 COSM102019420 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.8105C>T p.S2702F 16:72787429-72787429 3
15 COSM149331772 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.11050G>A p.D3684N 16:72787226-72787226 3
16 COSM102023144 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.3083G>A p.G1028E 16:72796857-72796857 3
17 COSM102047764 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.8308G>A p.D2770N 16:72787226-72787226 3
18 COSM87286441 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.1991C>T p.S664F 16:72958155-72958155 3
19 COSM102036925 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.-23-7190C>T p.? 16:72958155-72958155 3
20 COSM149266372 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.2084C>T p.P695L 16:72958062-72958062 3
21 COSM102022243 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.-23-7097C>T p.? 16:72958062-72958062 3
22 COSM87274293 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.5825G>A p.G1942E 16:72796857-72796857 3
23 COSM104882801 XPO1 skin,NS,carcinoma,basal cell carcinoma c.782G>A p.R261Q 2:61496985-61496985 3
24 COSM104236272 XPO1 skin,NS,carcinoma,basal cell carcinoma c.782G>A p.R261Q 2:61496985-61496985 3
25 COSM101976974 XPO1 skin,NS,carcinoma,basal cell carcinoma c.782G>A p.R261Q 2:61496985-61496985 3
26 COSM87040659 TSC2 skin,NS,carcinoma,basal cell carcinoma c.869C>T p.P290L 16:2058767-2058767 3
27 COSM101179498 TSC2 skin,NS,carcinoma,basal cell carcinoma c.1913C>T p.S638F 16:2071897-2071897 3
28 COSM150324396 TSC2 skin,NS,carcinoma,basal cell carcinoma c.869C>T p.P290L 16:2058767-2058767 3
29 COSM101191558 TSC2 skin,NS,carcinoma,basal cell carcinoma c.722C>T p.P241L 16:2058767-2058767 3
30 COSM147706701 TSC2 skin,NS,carcinoma,basal cell carcinoma c.869C>T p.P290L 16:2058767-2058767 3
31 COSM150353664 TSC2 skin,NS,carcinoma,basal cell carcinoma c.2060C>T p.S687F 16:2071897-2071897 3
32 COSM151748023 TSC2 skin,NS,carcinoma,basal cell carcinoma c.679T>A p.C227S 16:2056674-2056674 3
33 COSM150576157 TSC2 skin,NS,carcinoma,basal cell carcinoma c.679T>A p.C227S 16:2056674-2056674 3
34 COSM149802478 TSC2 skin,NS,carcinoma,basal cell carcinoma c.679T>A p.C227S 16:2056674-2056674 3
35 COSM148980439 TSC2 skin,NS,carcinoma,basal cell carcinoma c.2060C>T p.S687F 16:2071897-2071897 3
36 COSM90415129 TSC2 skin,NS,carcinoma,basal cell carcinoma c.869C>T p.P290L 16:2058767-2058767 3
37 COSM149800636 TSC2 skin,NS,carcinoma,basal cell carcinoma c.2060C>T p.S687F 16:2071897-2071897 3
38 COSM148991757 TSC2 skin,NS,carcinoma,basal cell carcinoma c.869C>T p.P290L 16:2058767-2058767 3
39 COSM151753165 TSC2 skin,NS,carcinoma,basal cell carcinoma c.869C>T p.P290L 16:2058767-2058767 3
40 COSM151513825 TSC2 skin,NS,carcinoma,basal cell carcinoma c.679T>A p.C227S 16:2056674-2056674 3
41 COSM151371066 TSC2 skin,NS,carcinoma,basal cell carcinoma c.679T>A p.C227S 16:2056674-2056674 3
42 COSM148982237 TSC2 skin,NS,carcinoma,basal cell carcinoma c.679T>A p.C227S 16:2056674-2056674 3
43 COSM136628294 TSC2 skin,NS,carcinoma,basal cell carcinoma c.902C>T p.P301L 16:2058767-2058767 3
44 COSM110103971 TSC2 skin,NS,carcinoma,basal cell carcinoma c.568T>A p.C190S 16:2056674-2056674 3
45 COSM150583851 TSC2 skin,NS,carcinoma,basal cell carcinoma c.869C>T p.P290L 16:2058767-2058767 3
46 COSM102616914 TSC2 skin,NS,carcinoma,basal cell carcinoma c.2060C>T p.S687F 16:2071897-2071897 3
47 COSM136618116 TSC2 skin,NS,carcinoma,basal cell carcinoma c.712T>A p.C238S 16:2056674-2056674 3
48 COSM110102044 TSC2 skin,NS,carcinoma,basal cell carcinoma c.1949C>T p.S650F 16:2071897-2071897 3
49 COSM150574866 TSC2 skin,NS,carcinoma,basal cell carcinoma c.2060C>T p.S687F 16:2071897-2071897 3
50 COSM102629996 TSC2 skin,NS,carcinoma,basal cell carcinoma c.869C>T p.P290L 16:2058767-2058767 3

Expression for Infiltrative Basal Cell Carcinoma

Search GEO for disease gene expression data for Infiltrative Basal Cell Carcinoma.

Pathways for Infiltrative Basal Cell Carcinoma

Pathways related to Infiltrative Basal Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.79 KRT20 KRT17 KRT15
2 11.27 KRT20 KRT17 KRT15
3 10.78 KRT20 KRT17 KRT15

GO Terms for Infiltrative Basal Cell Carcinoma

Cellular components related to Infiltrative Basal Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intermediate filament GO:0005882 8.8 KRT20 KRT17 KRT15

Biological processes related to Infiltrative Basal Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratinization GO:0031424 9.33 KRT20 KRT17 KRT15
2 hair follicle morphogenesis GO:0031069 9.26 NGFR KRT17
3 intermediate filament organization GO:0045109 8.96 KRT20 KRT17
4 cornification GO:0070268 8.8 KRT20 KRT17 KRT15

Molecular functions related to Infiltrative Basal Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of cytoskeleton GO:0005200 8.96 KRT20 KRT15
2 structural molecule activity GO:0005198 8.8 KRT20 KRT17 KRT15

Sources for Infiltrative Basal Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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