MCID: INF036
MIFTS: 18

Inflammatory and Toxic Neuropathy

Categories: Neuronal diseases

Aliases & Classifications for Inflammatory and Toxic Neuropathy

MalaCards integrated aliases for Inflammatory and Toxic Neuropathy:

Name: Inflammatory and Toxic Neuropathy 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:2537
ICD9CM 35 357 357.9
UMLS 73 C0154758

Summaries for Inflammatory and Toxic Neuropathy

MalaCards based summary : Inflammatory and Toxic Neuropathy is related to critical illness polyneuropathy and graves disease 1. An important gene associated with Inflammatory and Toxic Neuropathy is MIA3 (MIA SH3 Domain ER Export Factor 3), and among its related pathways/superpathways are Fatty acid metabolism and Cyclophosphamide Pathway, Pharmacodynamics. Affiliated tissues include liver, and related phenotypes are homeostasis/metabolism and mortality/aging

Related Diseases for Inflammatory and Toxic Neuropathy

Diseases related to Inflammatory and Toxic Neuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 critical illness polyneuropathy 10.0 INS SCN4A
2 graves disease 1 10.0 INS SCN4A
3 hypokalemic periodic paralysis, type 1 10.0 INS SCN4A
4 autonomic neuropathy 9.9 INS SPTLC1
5 alcoholic liver cirrhosis 9.9 ADH4 ALDH2
6 peripheral nervous system disease 9.9 INS SPTLC1
7 alcoholic neuropathy 9.3 ADH4 ALDH2 MIA3 SPTLC1 UROS

Graphical network of the top 20 diseases related to Inflammatory and Toxic Neuropathy:



Diseases related to Inflammatory and Toxic Neuropathy

Symptoms & Phenotypes for Inflammatory and Toxic Neuropathy

MGI Mouse Phenotypes related to Inflammatory and Toxic Neuropathy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.43 ALDH2 INS MIA3 SCN4A SPTLC1 UROS
2 mortality/aging MP:0010768 9.1 ALDH2 INS MIA3 SCN4A SPTLC1 UROS

Drugs & Therapeutics for Inflammatory and Toxic Neuropathy

Search Clinical Trials , NIH Clinical Center for Inflammatory and Toxic Neuropathy

Genetic Tests for Inflammatory and Toxic Neuropathy

Anatomical Context for Inflammatory and Toxic Neuropathy

MalaCards organs/tissues related to Inflammatory and Toxic Neuropathy:

41
Liver

Publications for Inflammatory and Toxic Neuropathy

Variations for Inflammatory and Toxic Neuropathy

Expression for Inflammatory and Toxic Neuropathy

Search GEO for disease gene expression data for Inflammatory and Toxic Neuropathy.

Pathways for Inflammatory and Toxic Neuropathy

Pathways related to Inflammatory and Toxic Neuropathy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.12 ADH4 ALDH2
2
Show member pathways
10.45 ADH4 ALDH2
3
Show member pathways
9.8 ADH4 ALDH2

GO Terms for Inflammatory and Toxic Neuropathy

Biological processes related to Inflammatory and Toxic Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 wound healing GO:0042060 9.16 INS MIA3
2 ethanol oxidation GO:0006069 8.96 ADH4 ALDH2
3 alcohol metabolic process GO:0006066 8.62 ADH4 ALDH2

Molecular functions related to Inflammatory and Toxic Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 NAD binding GO:0051287 8.96 ADH4 ALDH2
2 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor GO:0016620 8.62 ADH4 ALDH2

Sources for Inflammatory and Toxic Neuropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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