IBD12
MCID: INF073
MIFTS: 27

Inflammatory Bowel Disease 12 (IBD12)

Categories: Blood diseases, Bone diseases, Gastrointestinal diseases, Genetic diseases, Immune diseases, Rare diseases

Aliases & Classifications for Inflammatory Bowel Disease 12

MalaCards integrated aliases for Inflammatory Bowel Disease 12:

Name: Inflammatory Bowel Disease 12 56 12 13 15 71
Ibd12 56 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0110887
OMIM 56 612241
OMIM Phenotypic Series 56 PS266600
UMLS 71 C2677105

Summaries for Inflammatory Bowel Disease 12

Disease Ontology : 12 An inflammatory bowel disease that has material basis in variation in the chromosome region 3p21.3.

MalaCards based summary : Inflammatory Bowel Disease 12, also known as ibd12, is related to inflammatory bowel disease and inflammatory bowel disease 17. An important gene associated with Inflammatory Bowel Disease 12 is IBD12 (Inflammatory Bowel Disease 12), and among its related pathways/superpathways are Acyl chain remodelling of PE and Fc gamma R-mediated phagocytosis. The drugs Bisacodyl and Laxatives have been mentioned in the context of this disorder. Affiliated tissues include colon, and related phenotype is Increased shRNA abundance.

More information from OMIM: 612241 PS266600

Related Diseases for Inflammatory Bowel Disease 12

Symptoms & Phenotypes for Inflammatory Bowel Disease 12

Clinical features from OMIM:

612241

GenomeRNAi Phenotypes related to Inflammatory Bowel Disease 12 according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance GR00327-A 8.8 ENTPD1 GPX1 MST1

Drugs & Therapeutics for Inflammatory Bowel Disease 12

Drugs for Inflammatory Bowel Disease 12 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bisacodyl Approved Phase 3 603-50-9
2 Laxatives Phase 3
3 Cathartics Phase 3
4 Gastrointestinal Agents Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Multi-centre Endoscopist Blinded Randomized Clinical Trial to Compare Two Bowel Preparations After a Colonoscopy With Inadequate Bowel Preparation Completed NCT02976805 Phase 3 4L PegLyte + 15 mg bisacodyl;6L PegLyte + 15 mg bisacodyl
2 Efficacy and Safety of Fecal Microbiota Transplantation for Severe Clostridium Difficile Associated Colitis Terminated NCT01959048 fecal microbiota transplantation

Search NIH Clinical Center for Inflammatory Bowel Disease 12

Genetic Tests for Inflammatory Bowel Disease 12

Anatomical Context for Inflammatory Bowel Disease 12

MalaCards organs/tissues related to Inflammatory Bowel Disease 12:

40
Colon

Publications for Inflammatory Bowel Disease 12

Articles related to Inflammatory Bowel Disease 12:

(show all 21)
# Title Authors PMID Year
1
Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci. 56
21151127 2011
2
Genome-wide association identifies multiple ulcerative colitis susceptibility loci. 56
20228799 2010
3
Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study. 56
19122664 2009
4
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. 56
18587394 2008
5
Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis. 56
18438405 2008
6
Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease. 56
18438406 2008
7
Gene-centric association mapping of chromosome 3p implicates MST1 in IBD pathogenesis. 56
19079170 2008
8
Genome-wide association study for Crohn's disease in the Quebec Founder Population identifies multiple validated disease loci. 56
17804789 2007
9
Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility. 56
17554261 2007
10
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. 56
17554300 2007
11
Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis. 56
17435756 2007
12
Novel Crohn disease locus identified by genome-wide association maps to a gene desert on 5p13.1 and modulates expression of PTGER4. 56
17447842 2007
13
Genetic analysis in Finnish families with inflammatory bowel disease supports linkage to chromosome 3p21. 56
11378820 2001
14
Ulcerative colitis and adenocarcinoma of the colon in G alpha i2-deficient mice. 56
7663509 1995
15
The clinical efficacy of curcumin-containing nutraceuticals: An overview of systematic reviews. 61
29890252 2018
16
Vedolizumab as Induction and Maintenance for Inflammatory Bowel Disease: 12-month Effectiveness and Safety. 61
29562271 2018
17
Switching from reference infliximab to CT-P13 in patients with inflammatory bowel disease: 12 months results. 61
28902041 2017
18
The association of H. pylori and colorectal adenoma: does it exist in the US Hispanic population? 61
25436126 2014
19
Access to specialist gastroenterology care in Canada: comparison of wait times and consensus targets. 61
18299735 2008
20
Capsule endoscopy: a single-centre experience with the first 226 capsules. 61
15457294 2004
21
Circulating antioxidant concentrations in children with inflammatory bowel disease. 61
9129480 1997

Variations for Inflammatory Bowel Disease 12

Expression for Inflammatory Bowel Disease 12

Search GEO for disease gene expression data for Inflammatory Bowel Disease 12.

Pathways for Inflammatory Bowel Disease 12

Pathways related to Inflammatory Bowel Disease 12 according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.36 PLA2G6 PLA2G4B
2 10.92 PLA2G6 PLA2G4B
3
Show member pathways
10.87 PLA2G6 PLA2G4B GPX1

GO Terms for Inflammatory Bowel Disease 12

Biological processes related to Inflammatory Bowel Disease 12 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipid metabolic process GO:0006629 9.43 PLA2G6 PLA2G4B GPX1
2 lipid catabolic process GO:0016042 9.32 PLA2G6 PLA2G4B
3 arachidonic acid metabolic process GO:0019369 9.16 PLA2G4B GPX1
4 phosphatidylcholine acyl-chain remodeling GO:0036151 8.96 PLA2G6 PLA2G4B
5 phosphatidylethanolamine acyl-chain remodeling GO:0036152 8.62 PLA2G6 PLA2G4B

Molecular functions related to Inflammatory Bowel Disease 12 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phospholipase A2 activity GO:0004623 9.26 PLA2G6 PLA2G4B
2 phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine) GO:0102568 9.16 PLA2G6 PLA2G4B
3 phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine) GO:0102567 8.96 PLA2G6 PLA2G4B
4 lysophospholipase activity GO:0004622 8.62 PLA2G6 PLA2G4B

Sources for Inflammatory Bowel Disease 12

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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