Inflammatory Bowel Disease 14 (IBD14)

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Disease Ontology 12 DOID:0110895 OMIM 56 612245 OMIM Phenotypic Series 56 PS266600

MeSH 43 D015212 MedGen 41 C2677100 UMLS 71 C2677100

UniProtKB/Swiss-Prot : ⁷³ Inflammatory bowel disease 14: A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints.

MalaCards based summary : Inflammatory Bowel Disease 14, also known as ibd14, is related to anoxia and diffuse cutaneous systemic sclerosis. An important gene associated with Inflammatory Bowel Disease 14 is IRF5 (Interferon Regulatory Factor 5), and among its related pathways/superpathways are Degradation of the extracellular matrix and Immune response IFN alpha/beta signaling pathway. Affiliated tissues include eye, colon and skin, and related phenotypes are homeostasis/metabolism and hematopoietic system

Disease Ontology : ¹² An inflammatory bowel disease that has material basis in variation in the IRF5 gene on chromosome 7q32.

More information from OMIM: 612245 PS266600

Clinical features from OMIM:

612245

Search Clinical Trials , NIH Clinical Center for Inflammatory Bowel Disease 14

Search GEO for disease gene expression data for Inflammatory Bowel Disease 14.