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IBD16
MCID: INF075
MIFTS: 30

Inflammatory Bowel Disease 16 (IBD16)

Categories: Blood diseases, Bone diseases, Gastrointestinal diseases, Genetic diseases, Immune diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for Inflammatory Bowel Disease 16

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MalaCards integrated aliases for Inflammatory Bowel Disease 16:

Name: Inflammatory Bowel Disease 16 56 12 13 15 71
Ibd16 56 12

Classifications:

MalaCards categories:
Global: Genetic diseases Rare diseases
Anatomical: Gastrointestinal diseases Bone diseases Blood diseases Immune diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:0110896
OMIM 56 612259
OMIM Phenotypic Series 56 PS266600
UMLS 71 C2677093
Sources

Summaries for Inflammatory Bowel Disease 16

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Disease Ontology : 12 An inflammatory bowel disease that has material basis in variation in the chromosome region 9q32.

MalaCards based summary : Inflammatory Bowel Disease 16, also known as ibd16, is related to inflammatory bowel disease and precursor lymphoblastic lymphoma/leukemia. An important gene associated with Inflammatory Bowel Disease 16 is IBD16 (Inflammatory Bowel Disease-16), and among its related pathways/superpathways are Cell surface interactions at the vascular wall and Cell adhesion molecules (CAMs). Affiliated tissues include t cells, myeloid and spinal cord, and related phenotypes are Reduced mammosphere formation and hematopoietic system

More information from OMIM: 612259 PS266600
Sources

Related Diseases for Inflammatory Bowel Disease 16

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Diseases in the Inflammatory Bowel Disease family:

Inflammatory Bowel Disease 11 Inflammatory Bowel Disease 1
Inflammatory Bowel Disease 2 Inflammatory Bowel Disease 3
Inflammatory Bowel Disease 7 Inflammatory Bowel Disease 5
Inflammatory Bowel Disease 8 Inflammatory Bowel Disease 6
Inflammatory Bowel Disease 4 Inflammatory Bowel Disease 9
Inflammatory Bowel Disease 10 Inflammatory Bowel Disease 12
Inflammatory Bowel Disease 13 Inflammatory Bowel Disease 14
Inflammatory Bowel Disease 15 Inflammatory Bowel Disease 16
Inflammatory Bowel Disease 17 Inflammatory Bowel Disease 18
Inflammatory Bowel Disease 19 Inflammatory Bowel Disease 20
Inflammatory Bowel Disease 21 Inflammatory Bowel Disease 22
Inflammatory Bowel Disease 23 Inflammatory Bowel Disease 24
Inflammatory Bowel Disease 25, Autosomal Recessive Inflammatory Bowel Disease 26
Inflammatory Bowel Disease 27 Inflammatory Bowel Disease 28, Autosomal Recessive
Inflammatory Bowel Disease 29 Inflammatory Bowel Disease 28
Inflammatory Bowel Disease 25 Rare Inflammatory Bowel Disease

Diseases related to Inflammatory Bowel Disease 16 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 19)
# Related Disease Score Top Affiliating Genes
1 inflammatory bowel disease 11.4
2 precursor lymphoblastic lymphoma/leukemia 10.2 CD7 CD2
3 precursor t-lymphoblastic lymphoma/leukemia 10.2 CD7 CD2
4 parapsoriasis 10.2 CD7 CD2
5 follicular mucinosis 10.2 CD7 CD2
6 acute monoblastic leukemia 10.2 KMT2A CD44
7 aggressive nk-cell leukemia 10.1 CD7 CD2
8 t-cell adult acute lymphocytic leukemia 10.1 CD7 CD2
9 adult acute lymphocytic leukemia 10.1 CD7 CD2
10 central nervous system leukemia 10.1 LIF CD7
11 myeloid sarcoma 10.0 KMT2A CD7
12 pancytopenia 9.9 KMT2A CD7 CD2
13 aseptic meningitis 9.7 CD44 CD2
14 leukemia, chronic lymphocytic 9.4 KMT2A CD7 CD44 CD2
15 acute promyelocytic leukemia 9.2 KMT2A ITGAM CD7 CD44
16 leukemia, acute lymphoblastic 9.1 KMT2A ITGAM HPRT1 CD7
17 leukemia, acute myeloid 9.1 KMT2A ITGAM CD7 CD44 CD2
18 lymphoma, non-hodgkin, familial 8.7 KMT2A ITGAM HPRT1 CD7 CD44 CD2
19 retinitis pigmentosa 8.3 LIF KMT2A ITGAM HPRT1 CD44 ADCY10

Graphical network of the top 20 diseases related to Inflammatory Bowel Disease 16:



Diseases related to Inflammatory Bowel Disease 16
Sources

Symptoms & Phenotypes for Inflammatory Bowel Disease 16

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Clinical features from OMIM:

612259

GenomeRNAi Phenotypes related to Inflammatory Bowel Disease 16 according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.02 CD44 CD6 CD7 HPRT1 KMT2A

MGI Mouse Phenotypes related to Inflammatory Bowel Disease 16:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.56 CD44 CD6 CD7 FFAR2 HPRT1 ITGAM
2 immune system MP:0005387 9.23 CD44 CD6 CD7 FFAR2 HPRT1 ITGAM
Sources

Drugs & Therapeutics for Inflammatory Bowel Disease 16

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Search Clinical Trials , NIH Clinical Center for Inflammatory Bowel Disease 16

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Genetic Tests for Inflammatory Bowel Disease 16

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Anatomical Context for Inflammatory Bowel Disease 16

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MalaCards organs/tissues related to Inflammatory Bowel Disease 16:

40
T Cells, Myeloid, Spinal Cord, Bone, Nk Cells
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Publications for Inflammatory Bowel Disease 16

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Articles related to Inflammatory Bowel Disease 16:

(show all 16)
# Title Authors PMID Year
1
TNFSF15 transcripts from risk haplotype for Crohn's disease are overexpressed in stimulated T cells. 56
19124533 2009
2
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. 56
18587394 2008
3
Contribution of TNFSF15 gene variants to Crohn's disease susceptibility confirmed in UK population. 56
18338776 2008
4
TNFSF15 is an ethnic-specific IBD gene. 56
17663424 2007
5
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. 56
17554300 2007
6
Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis. 56
17435756 2007
7
Novel Crohn disease locus identified by genome-wide association maps to a gene desert on 5p13.1 and modulates expression of PTGER4. 56
17447842 2007
8
Single nucleotide polymorphisms in TNFSF15 confer susceptibility to Crohn's disease. 56
16221758 2005
9
Identification of novel susceptibility loci for inflammatory bowel disease on chromosomes 1p, 3q, and 4q: evidence for epistasis between 1p and IBD1. 56
9636179 1998
10
Prevalence and predictive factors for gastrointestinal pathology in young men evaluated for iron deficiency anemia. 61
23192647 2013
11
Prevalence of rubella serum antibody in autoimmune diseases. 61
22641586 2012
12
Colonoscopic lesions in patients with spinal cord injury. 61
19777861 2009
13
A report on efficacy and safety of azathioprine in a group of inflammatory bowel disease patients in northwest Greece. 61
12845970 2003
14
The terminal ileum is affected in patients with lymphocytic or collagenous colitis. 61
12409725 2002
15
Ankylosing spondylitis--the female aspect. 61
9458214 1998
16
Circulating and mucosal concentrations of tumour necrosis factor and inhibitor(s) in chronic inflammatory bowel disease. 61
8495600 1993
Sources

Variations for Inflammatory Bowel Disease 16

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Expression for Inflammatory Bowel Disease 16

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Search GEO for disease gene expression data for Inflammatory Bowel Disease 16.
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Pathways for Inflammatory Bowel Disease 16

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Pathways related to Inflammatory Bowel Disease 16 according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Cell surface interactions at the vascular wall 65
Show member pathways
 11.75 ITGAM CD44 CD2
2
Cell adhesion molecules (CAMs) 36
11.6 ITGAM CD6 CD2
3
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 64
11.4 ITGAM CD44 CD2
4
Innate Lymphoid Cell Differentiation Pathways 64
11.03 ITGAM CD7 CD44
5
Hematopoietic cell lineage 36
10.92 ITGAM CD7 CD44 CD2
Sources

GO Terms for Inflammatory Bowel Disease 16

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Biological processes related to Inflammatory Bowel Disease 16 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.62 ITGAM FFAR2 CD7 CD6
2 cell adhesion GO:0007155 9.56 ITGAM CD6 CD44 CD2
3 leukocyte migration GO:0050900 9.33 ITGAM CD44 CD2
4 positive regulation of interleukin-8 secretion GO:2000484 8.96 FFAR2 CD2
5 T cell activation GO:0042110 8.8 CD7 CD44 CD2
Sources

Sources for Inflammatory Bowel Disease 16

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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