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IBD16
MCID: INF075
MIFTS: 32

Inflammatory Bowel Disease 16 (IBD16)

Categories: Blood diseases, Bone diseases, Gastrointestinal diseases, Genetic diseases, Immune diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for Inflammatory Bowel Disease 16

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MalaCards integrated aliases for Inflammatory Bowel Disease 16:

Name: Inflammatory Bowel Disease 16 57 12 13 15 71
Ibd16 57 12

Classifications:

MalaCards categories:
Global: Genetic diseases Rare diseases
Anatomical: Gastrointestinal diseases Bone diseases Blood diseases Immune diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:0110896
OMIM® 57 612259
OMIM Phenotypic Series 57 PS266600
UMLS 71 C2677093
Sources

Summaries for Inflammatory Bowel Disease 16

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Disease Ontology : 12 An inflammatory bowel disease that has material basis in variation in the chromosome region 9q32.

MalaCards based summary : Inflammatory Bowel Disease 16, also known as ibd16, is related to inflammatory bowel disease and parapsoriasis. An important gene associated with Inflammatory Bowel Disease 16 is IBD16 (Inflammatory Bowel Disease-16), and among its related pathways/superpathways are Cytokine Signaling in Immune system and PAK Pathway. Affiliated tissues include spinal cord and t cells, and related phenotypes are Decreased viability and Decreased viability

More information from OMIM: 612259 PS266600
Sources

Related Diseases for Inflammatory Bowel Disease 16

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Diseases in the Inflammatory Bowel Disease family:

Inflammatory Bowel Disease 11 Inflammatory Bowel Disease 1
Inflammatory Bowel Disease 2 Inflammatory Bowel Disease 3
Inflammatory Bowel Disease 7 Inflammatory Bowel Disease 5
Inflammatory Bowel Disease 8 Inflammatory Bowel Disease 6
Inflammatory Bowel Disease 4 Inflammatory Bowel Disease 9
Inflammatory Bowel Disease 10 Inflammatory Bowel Disease 12
Inflammatory Bowel Disease 13 Inflammatory Bowel Disease 14
Inflammatory Bowel Disease 15 Inflammatory Bowel Disease 16
Inflammatory Bowel Disease 17 Inflammatory Bowel Disease 18
Inflammatory Bowel Disease 19 Inflammatory Bowel Disease 20
Inflammatory Bowel Disease 21 Inflammatory Bowel Disease 22
Inflammatory Bowel Disease 23 Inflammatory Bowel Disease 24
Inflammatory Bowel Disease 25, Autosomal Recessive Inflammatory Bowel Disease 26
Inflammatory Bowel Disease 27 Inflammatory Bowel Disease 28, Autosomal Recessive
Inflammatory Bowel Disease 29 Inflammatory Bowel Disease 30
Inflammatory Bowel Disease 28 Inflammatory Bowel Disease 25
Rare Inflammatory Bowel Disease

Diseases related to Inflammatory Bowel Disease 16 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 37)
# Related Disease Score Top Affiliating Genes
1 inflammatory bowel disease 30.1 IBD16 HPRT1 CD40LG CD40 CCL3
2 parapsoriasis 10.2 CD7 CD2
3 follicular mucinosis 10.2 CD7 CD2
4 lethal midline granuloma 10.2 CD7 CD2
5 aggressive nk-cell leukemia 10.2 CD7 CD2
6 t-cell adult acute lymphocytic leukemia 10.2 CD7 CD2
7 adult acute lymphocytic leukemia 10.2 CD7 CD2
8 cataract 4, multiple types 10.0 HPRT1 ADCY10
9 stachybotrys chartarum 10.0 LIF CCL3
10 aseptic meningitis 9.9 CD44 CD2 CCL3
11 light fixation seizure syndrome 9.9 CD40LG CD40
12 geotrichosis 9.8 CD40LG CD40
13 sulfamethoxazole allergy 9.8 CD40LG CD40
14 immunodeficiency with hyper-igm, type 4 9.8 CD40LG CD40
15 immunodeficiency with hyper-igm, type 5 9.8 CD40LG CD40
16 immunodeficiency with hyper-igm, type 3 9.8 CD40LG CD40
17 african tick-bite fever 9.8 CD40LG CCL3
18 immunoglobulin alpha deficiency 9.7 CD40LG CD40
19 immunodeficiency with hyper-igm, type 2 9.7 CD40LG CD40
20 mast-cell leukemia 9.7 CD44 CCL3
21 cd40 ligand deficiency 9.7 CD40LG CD40
22 lymphoma, non-hodgkin, familial 9.6 DNTT CD7 CD44 CD40
23 immunodeficiency with hyper-igm, type 1 9.6 HPRT1 CD40LG CD40
24 plasmodium vivax malaria 9.6 CD40LG CD40
25 leukemia, acute myeloid 9.5 DNTT CD7 CD44 CD2
26 toxoplasmosis 9.5 CD40LG CD40 CCL3
27 myocarditis 9.5 CD40LG CD40 CCL3
28 leukemia, acute lymphoblastic 9.5 HPRT1 DNTT CD7 CD40 CD2
29 behcet syndrome 9.4 CD40LG CD40 CCL3
30 burkitt lymphoma 9.4 DNTT CD44 CD40LG CD40
31 immune deficiency disease 9.3 CD40LG CD40 CD2 CCL3
32 leukemia, chronic lymphocytic 9.2 DNTT CD7 CD40LG CD40 CD2
33 multiple sclerosis 9.1 LIF CD40LG CD40 CD2 CCL3
34 malaria 9.1 CD44 CD40LG CD40 CD2 CCL3
35 retinitis pigmentosa 9.1 LIF HPRT1 HPGDS DNTT CD44 ADCY10
36 rheumatoid arthritis 9.1 LIF CD44 CD40LG CD40 CCL3
37 asthma 9.0 CD44 CD40LG CD40 CCL3 ADCY10

Graphical network of the top 20 diseases related to Inflammatory Bowel Disease 16:



Diseases related to Inflammatory Bowel Disease 16
Sources

Symptoms & Phenotypes for Inflammatory Bowel Disease 16

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Clinical features from OMIM®:

612259 (Updated 05-Mar-2021)

GenomeRNAi Phenotypes related to Inflammatory Bowel Disease 16 according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00240-S-1 9.61 ADCY10 CD40LG CD44 LIF
2 Decreased viability GR00249-S 9.61 ADCY10
3 Decreased viability GR00381-A-1 9.61 LIF
4 Decreased viability GR00381-A-2 9.61 LIF
5 Decreased viability GR00381-A-3 9.61 LIF
6 Decreased viability GR00402-S-2 9.61 LIF
7 Reduced mammosphere formation GR00396-S 9.02 CCL3 CD44 CD7 HPGDS HPRT1

MGI Mouse Phenotypes related to Inflammatory Bowel Disease 16:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.56 CD40 CD40LG CD44 CD7 DNTT HPGDS
2 immune system MP:0005387 9.23 CD40 CD40LG CD44 CD7 DNTT HPGDS
Sources

Drugs & Therapeutics for Inflammatory Bowel Disease 16

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Search Clinical Trials , NIH Clinical Center for Inflammatory Bowel Disease 16

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Genetic Tests for Inflammatory Bowel Disease 16

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Anatomical Context for Inflammatory Bowel Disease 16

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MalaCards organs/tissues related to Inflammatory Bowel Disease 16:

40
Spinal Cord, T Cells
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Publications for Inflammatory Bowel Disease 16

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Articles related to Inflammatory Bowel Disease 16:

(show all 16)
# Title Authors PMID Year
1
TNFSF15 transcripts from risk haplotype for Crohn's disease are overexpressed in stimulated T cells. 57
19124533 2009
2
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. 57
18587394 2008
3
Contribution of TNFSF15 gene variants to Crohn's disease susceptibility confirmed in UK population. 57
18338776 2008
4
TNFSF15 is an ethnic-specific IBD gene. 57
17663424 2007
5
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. 57
17554300 2007
6
Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis. 57
17435756 2007
7
Novel Crohn disease locus identified by genome-wide association maps to a gene desert on 5p13.1 and modulates expression of PTGER4. 57
17447842 2007
8
Single nucleotide polymorphisms in TNFSF15 confer susceptibility to Crohn's disease. 57
16221758 2005
9
Identification of novel susceptibility loci for inflammatory bowel disease on chromosomes 1p, 3q, and 4q: evidence for epistasis between 1p and IBD1. 57
9636179 1998
10
Prevalence and predictive factors for gastrointestinal pathology in young men evaluated for iron deficiency anemia. 61
23192647 2013
11
Prevalence of rubella serum antibody in autoimmune diseases. 61
22641586 2012
12
Colonoscopic lesions in patients with spinal cord injury. 61
19777861 2009
13
A report on efficacy and safety of azathioprine in a group of inflammatory bowel disease patients in northwest Greece. 61
12845970 2003
14
The terminal ileum is affected in patients with lymphocytic or collagenous colitis. 61
12409725 2002
15
Ankylosing spondylitis--the female aspect. 61
9458214 1998
16
Circulating and mucosal concentrations of tumour necrosis factor and inhibitor(s) in chronic inflammatory bowel disease. 61
8495600 1993
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Variations for Inflammatory Bowel Disease 16

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Expression for Inflammatory Bowel Disease 16

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Search GEO for disease gene expression data for Inflammatory Bowel Disease 16.
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Pathways for Inflammatory Bowel Disease 16

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Pathways related to Inflammatory Bowel Disease 16 according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Cytokine Signaling in Immune system 65
Show member pathways
 12.98 LIF CD44 CD40LG CD40 CCL3
2
PAK Pathway 63
Show member pathways
 12.87 LIF CD40LG CD40 CD2 CCL3
3
Cell adhesion molecules 36
11.51 CD40LG CD40 CD2
4
Primary immunodeficiency 36
11.04 CD40LG CD40
5
Innate Lymphoid Cell Differentiation Pathways 64
11.03 CD7 CD44 CCL3
6
Inflammatory Response Pathway 1
10.95 CD40LG CD40
7
Hematopoietic cell lineage 36
10.92 DNTT CD7 CD44 CD2
8
A-beta Pathways: Uptake and Degradation 64
10.87 CD40LG CD40
9
CD40/CD40L signaling 1
10.8 CD40LG CD40
10
G-protein signaling_Rap2B regulation pathway 23
10.46 LIF CD40LG CD2 CCL3
Sources

GO Terms for Inflammatory Bowel Disease 16

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Cellular components related to Inflammatory Bowel Disease 16 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 8.92 CD44 CD40LG CD40 CD2

Biological processes related to Inflammatory Bowel Disease 16 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.62 LIF CD7 CD40LG CCL3
2 inflammatory response GO:0006954 9.56 CD44 CD40LG CD40 CCL3
3 positive regulation of interleukin-12 production GO:0032735 9.46 CD40LG CD40
4 protein kinase B signaling GO:0043491 9.43 CD40 CCL3
5 B cell proliferation GO:0042100 9.4 CD40LG CD40
6 positive regulation of endothelial cell apoptotic process GO:2000353 9.37 CD40LG CD40
7 CD40 signaling pathway GO:0023035 9.16 CD40LG CD40
8 regulation of immunoglobulin production GO:0002637 8.96 CD40LG CD40
9 T cell activation GO:0042110 8.8 CD7 CD44 CD2

Molecular functions related to Inflammatory Bowel Disease 16 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.33 LIF CD40LG CCL3
2 signaling receptor activity GO:0038023 9.13 CD7 CD40 CD2
3 magnesium ion binding GO:0000287 8.8 HPRT1 HPGDS ADCY10
Sources

Sources for Inflammatory Bowel Disease 16

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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