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IBD18
MCID: INF076
MIFTS: 39

Inflammatory Bowel Disease 18 (IBD18)

Categories: Blood diseases, Bone diseases, Gastrointestinal diseases, Genetic diseases, Immune diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for Inflammatory Bowel Disease 18

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MalaCards integrated aliases for Inflammatory Bowel Disease 18:

Name: Inflammatory Bowel Disease 18 56 12 29 13 15 71
Ibd18 56 12

Classifications:

MalaCards categories:
Global: Genetic diseases Rare diseases
Anatomical: Gastrointestinal diseases Bone diseases Blood diseases Immune diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:0110888
OMIM 56 612262
OMIM Phenotypic Series 56 PS266600
UMLS 71 C2677090
Sources

Summaries for Inflammatory Bowel Disease 18

About this section
Disease Ontology : 12 An inflammatory bowel disease that has material basis in variation in the chromosome region 5p13.1.

MalaCards based summary : Inflammatory Bowel Disease 18, also known as ibd18, is related to inflammatory bowel disease and cutaneous candidiasis. An important gene associated with Inflammatory Bowel Disease 18 is IBD18 (Inflammatory Bowel Disease-18), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. Affiliated tissues include t cells, bone and eye, and related phenotypes are hematopoietic system and cellular

More information from OMIM: 612262 PS266600
Sources

Related Diseases for Inflammatory Bowel Disease 18

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Diseases in the Inflammatory Bowel Disease family:

Inflammatory Bowel Disease 11 Inflammatory Bowel Disease 1
Inflammatory Bowel Disease 2 Inflammatory Bowel Disease 3
Inflammatory Bowel Disease 7 Inflammatory Bowel Disease 5
Inflammatory Bowel Disease 8 Inflammatory Bowel Disease 6
Inflammatory Bowel Disease 4 Inflammatory Bowel Disease 9
Inflammatory Bowel Disease 10 Inflammatory Bowel Disease 12
Inflammatory Bowel Disease 13 Inflammatory Bowel Disease 14
Inflammatory Bowel Disease 15 Inflammatory Bowel Disease 16
Inflammatory Bowel Disease 17 Inflammatory Bowel Disease 18
Inflammatory Bowel Disease 19 Inflammatory Bowel Disease 20
Inflammatory Bowel Disease 21 Inflammatory Bowel Disease 22
Inflammatory Bowel Disease 23 Inflammatory Bowel Disease 24
Inflammatory Bowel Disease 25, Autosomal Recessive Inflammatory Bowel Disease 26
Inflammatory Bowel Disease 27 Inflammatory Bowel Disease 28, Autosomal Recessive
Inflammatory Bowel Disease 29 Inflammatory Bowel Disease 28
Inflammatory Bowel Disease 25 Rare Inflammatory Bowel Disease

Diseases related to Inflammatory Bowel Disease 18 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 288)
# Related Disease Score Top Affiliating Genes
1 inflammatory bowel disease 28.8 NOD2 IL4 IL2 IL17A IL15 IL10
2 cutaneous candidiasis 10.5 IL17A CCR6
3 tropical endomyocardial fibrosis 10.4 IL4 IL10
4 endomyocardial fibrosis 10.4 IL4 IL10
5 vernal conjunctivitis 10.4 IL4 CCR6
6 autoimmune hepatitis type 1 10.3 IL4 IL10
7 nickel allergic contact dermatitis 10.3 IL4 IL10
8 palladium allergic contact dermatitis 10.3 IL17A IL10
9 neurosyphilis 10.3 IL17A IL10
10 spotted fever rickettsiosis 10.3 IL10 CTLA4
11 klebsiella pneumonia 10.3 IL17A CCR6
12 loiasis 10.3 IL4 IL10
13 mikulicz disease 10.3 IL4 IL10 CCR6
14 egg allergy 10.3 IL4 IL10 CCR6
15 cerebral sinovenous thrombosis 10.3 IL17A IL10
16 chronic conjunctivitis 10.3 IL4 IL10 CCR6
17 nut allergy 10.3 IL4 IL10 CCR6
18 genital herpes 10.3 IL4 IL10 CCR6
19 eales disease 10.2 IL4 IL10
20 peanut allergy 10.2 IL4 IL10 CCR6
21 nail disease 10.2 IL17A CCRL2 CCR6
22 trichinosis 10.2 IL4 IL10
23 gastritis 10.2 IL17A IL10 CCR6
24 pustulosis of palm and sole 10.2 IL17A CCR6
25 dacryoadenitis 10.2 IL17A IL10 CCR6
26 hyper ige recurrent infection syndrome 1 10.2 IL17A IL10 CCR6
27 transverse myelitis 10.2 IL17A IL10
28 gingival disease 10.2 IL17A IL10 CCR6
29 myelitis 10.2 IL17A IL10 CCR6
30 chediak-higashi syndrome 10.2 IL4 IL10 CCR6
31 yellow fever 10.2 IL4 IL17A CCR6
32 metal allergy 10.2 IL4 IL17A IL10
33 pneumonic tularemia 10.2 IL17A CCR6
34 autoimmune polyendocrine syndrome 10.2 IL17A IL10 CCR6
35 keratitis, hereditary 10.2 IL17A IL10 CCR6
36 mycetoma 10.2 IL17A IL10
37 allergic contact dermatitis 10.1 IL4 IL17A IL10
38 streptococcus pneumonia 10.1 IL4 IL17A IL10
39 trachoma 10.1 IL4 IL17A IL10
40 blastomycosis 10.1 IL17A CCR6
41 central nervous system vasculitis 10.1 IL17A CTLA4 CCR6
42 bone sarcoma 10.1 IL10 CTLA4
43 mycoplasma pneumoniae pneumonia 10.1 IL4 IL17A IL10
44 bacterial pneumonia 10.1 IL17A IL10 CCR6
45 reactive arthritis 10.1 IL17A IL10 CCR6
46 dermatitis herpetiformis 10.1 IL4 IL17A IL10
47 aggressive periodontitis 10.1 IL4 IL17A IL10
48 periodontitis 10.1 IL4 IL17A IL10
49 silicosis 10.1 IL4 IL17A IL10
50 bronchiolitis 10.1 IL4 IL17A IL10

Graphical network of the top 20 diseases related to Inflammatory Bowel Disease 18:



Diseases related to Inflammatory Bowel Disease 18
Sources

Symptoms & Phenotypes for Inflammatory Bowel Disease 18

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Clinical features from OMIM:

612262

MGI Mouse Phenotypes related to Inflammatory Bowel Disease 18:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.21 ATG16L1 CCR6 CCRL2 CD28 CTLA4 IL10
2 cellular MP:0005384 10.16 ATG16L1 CCRL2 CD28 IL10 IL2 IL4
3 cardiovascular system MP:0005385 10.13 ATG16L1 CCR6 CTLA4 IL10 IL15 IL2
4 digestive/alimentary MP:0005381 10.13 ATG16L1 CD28 CTLA4 IL10 IL17A IL2
5 endocrine/exocrine gland MP:0005379 10.1 ATG16L1 CD28 CTLA4 IL10 IL15 IL17A
6 homeostasis/metabolism MP:0005376 10.1 ATG16L1 CCR6 CD28 CTLA4 IL10 IL17A
7 immune system MP:0005387 10.07 ATG16L1 CCR6 CCRL2 CD28 CTLA4 IL10
8 integument MP:0010771 9.76 CD28 CTLA4 IL10 IL17A IL4 PDE6B
9 normal MP:0002873 9.56 CCR6 CCRL2 CD28 CTLA4 IL10 IL4
10 respiratory system MP:0005388 9.17 CTLA4 IL10 IL17A IL2 IL4 RAG1
Sources

Drugs & Therapeutics for Inflammatory Bowel Disease 18

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Search Clinical Trials , NIH Clinical Center for Inflammatory Bowel Disease 18

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Genetic Tests for Inflammatory Bowel Disease 18

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Genetic tests related to Inflammatory Bowel Disease 18:

# Genetic test Affiliating Genes
1 Inflammatory Bowel Disease 18 29
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Anatomical Context for Inflammatory Bowel Disease 18

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MalaCards organs/tissues related to Inflammatory Bowel Disease 18:

40
T Cells, Bone, Eye, Thymus, Thyroid, B Cells, Lymph Node
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Publications for Inflammatory Bowel Disease 18

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Articles related to Inflammatory Bowel Disease 18:

(show all 14)
# Title Authors PMID Year
1
Confirmation of multiple Crohn's disease susceptibility loci in a large Dutch-Belgian cohort. 56
19174780 2009
2
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. 56
18587394 2008
3
Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease. 56
18438406 2008
4
Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis. 56
18438405 2008
5
Systematic association mapping identifies NELL1 as a novel IBD disease gene. 56
17684544 2007
6
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. 56
17554300 2007
7
Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis. 56
17435756 2007
8
Novel Crohn disease locus identified by genome-wide association maps to a gene desert on 5p13.1 and modulates expression of PTGER4. 56
17447842 2007
9
First experience in colorectal surgery with a new robotic platform with haptic feedback. 61
28905524 2017
10
Incidence of surgical site infections postcolorectal resections without preoperative mechanical or antibiotic bowel preparation. 61
19725287 2009
11
Virtual colonoscopy vs conventional colonoscopy in patients at high risk of colorectal cancer--a prospective trial of 150 patients. 61
18462241 2009
12
Metabolic features of inflammatory bowel disease in a remission phase of the disease activity. 61
9651555 1998
13
[Coagulation changes in inflammatory intestinal disease]. 61
1546196 1992
14
Tumor necrosis factor-alpha is not elevated in children with inflammatory bowel disease. 61
2051274 1991
Sources

Variations for Inflammatory Bowel Disease 18

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Expression for Inflammatory Bowel Disease 18

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Search GEO for disease gene expression data for Inflammatory Bowel Disease 18.
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Pathways for Inflammatory Bowel Disease 18

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Pathways related to Inflammatory Bowel Disease 18 according to GeneCards Suite gene sharing:

(show all 27)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 13.85 RAG2 RAG1 NOD2 KLRB1 IL4 IL2
2
ERK Signaling 63
Show member pathways
 13.7 IL4 IL2 IL17A IL15 IL10 CD28
3
PEDF Induced Signaling 63
Show member pathways
 13.57 IL4 IL2 IL17A IL15 IL10 CD28
4
Akt Signaling 63
Show member pathways
 13.3 IL4 IL2 IL17A IL15 IL10 CD28
5
Cytokine Signaling in Immune system 65
Show member pathways
 13.24 RAG2 RAG1 NOD2 IL4 IL2 IL17A
6
PAK Pathway 63
Show member pathways
 13.16 IL4 IL2 IL17A IL15 IL10 CD28
7
Allograft rejection 1 36
Show member pathways
 12.65 IL4 IL2 IL17A IL15 IL10 CTLA4
8
T cell receptor signaling pathway 36
Show member pathways
 12.48 IL4 IL2 IL17A IL10 CTLA4 CD28
9
Th17 cell differentiation 36
Show member pathways
 12.45 NOD2 IL4 IL2 IL17A IL10 CD28
10
JAK-STAT signaling pathway (KEGG) 36
Show member pathways
 12.26 IL4 IL2 IL15 IL10
11
Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions 64
Show member pathways
 12.24 IL2 IL10 CCRL2 CCR6
12
NF-kappaB Signaling 4
12.21 RAG1 IL4 IL2 IL17A IL10 CTLA4
13
Immune response IFN alpha/beta signaling pathway 22
Show member pathways
 12.2 IL4 IL2 IL17A IL15 IL10
14
Th1 Differentiation Pathway 64
Show member pathways
 11.99 IL2 IL17A IL10 CD28
15
Interleukin-4 and 13 signaling 65
11.87 IL4 IL17A IL10
16
Rheumatoid arthritis 36
11.78 IL17A IL15 CTLA4 CD28
17
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 1
Show member pathways
 11.67 IL4 IL2 CTLA4
18
Microglia Activation During Neuroinflammation: Microglia Polarization 64
11.51 IL4 IL2 IL17A IL15 IL10
19
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 64
11.5 KLRB1 IL4 IL2 IL15 IL10 CD28
20
Th2 Differentiation Pathway 64
11.37 IL4 IL2 IL10 CD28
21
Inflammatory Response Pathway 1
11.28 IL4 IL2 CD28
22
Development and heterogeneity of the ILC family 1
11.25 IL4 IL17A IL15
23
T-Cell Receptor and Co-stimulatory Signaling 1
11.23 IL2 CTLA4 CD28
24
OX40 Pathway 63
11.13 IL4 IL2 IL10
25
Cytokines and Inflammatory Response 1
11.09 IL4 IL2 IL15 IL10
26
Innate Lymphoid Cell Differentiation Pathways 64
11.07 KLRB1 IL4 IL2 IL17A IL15 IL10
27
G-protein signaling_Rap2B regulation pathway 22
10.92 IL4 IL2 IL17A IL15 IL10
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GO Terms for Inflammatory Bowel Disease 18

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Cellular components related to Inflammatory Bowel Disease 18 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.55 IL17A CTLA4 CD28 CCRL2 CCR6
2 protein complex involved in cell adhesion GO:0098636 8.96 CTLA4 CD28
3 DNA recombinase complex GO:0097519 8.62 RAG2 RAG1

Biological processes related to Inflammatory Bowel Disease 18 according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 10.06 NOD2 IL4 IL2 IL17A IL10 CD28
2 cytokine-mediated signaling pathway GO:0019221 9.86 IL4 IL2 IL17A IL10
3 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.69 IL4 IL2 IL15
4 B cell differentiation GO:0030183 9.67 RAG2 RAG1 IL4 IL10
5 negative regulation of B cell proliferation GO:0030889 9.59 IL10 CTLA4
6 regulation of T cell differentiation GO:0045580 9.58 RAG1 IL15
7 positive regulation of T cell differentiation GO:0045582 9.58 RAG1 IL4 IL2
8 regulation of T cell proliferation GO:0042129 9.57 CTLA4 CD28
9 V(D)J recombination GO:0033151 9.55 RAG2 RAG1
10 positive regulation of MHC class II biosynthetic process GO:0045348 9.54 IL4 IL10
11 negative regulation of tumor necrosis factor biosynthetic process GO:0042536 9.52 IL4 IL10
12 regulation of regulatory T cell differentiation GO:0045589 9.5 IL2 CTLA4 CD28
13 positive regulation of tissue remodeling GO:0034105 9.49 IL2 IL15
14 type 2 immune response GO:0042092 9.48 IL4 IL10
15 regulation of isotype switching GO:0045191 9.46 IL4 IL10
16 positive regulation of T cell proliferation GO:0042102 9.46 IL4 IL2 IL15 CD28
17 pre-B cell allelic exclusion GO:0002331 9.43 RAG2 RAG1
18 positive regulation of interleukin-17 production GO:0032740 9.43 NOD2 IL2 IL15
19 immune response GO:0006955 9.32 RAG1 IL4 IL2 IL17A IL15 IL10
20 positive regulation of isotype switching to IgG isotypes GO:0048304 9.13 IL4 IL2 CD28

Molecular functions related to Inflammatory Bowel Disease 18 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 IL4 IL2 IL17A IL15 IL10
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Sources for Inflammatory Bowel Disease 18

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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