IBD18
MCID: INF076
MIFTS: 36

Inflammatory Bowel Disease 18 (IBD18)

Categories: Blood diseases, Bone diseases, Gastrointestinal diseases, Genetic diseases, Immune diseases, Rare diseases

Aliases & Classifications for Inflammatory Bowel Disease 18

MalaCards integrated aliases for Inflammatory Bowel Disease 18:

Name: Inflammatory Bowel Disease 18 57 12 29 13 15 71
Ibd18 57 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0110888
OMIM® 57 612262
OMIM Phenotypic Series 57 PS266600
UMLS 71 C2677090

Summaries for Inflammatory Bowel Disease 18

Disease Ontology : 12 An inflammatory bowel disease that has material basis in variation in the chromosome region 5p13.1.

MalaCards based summary : Inflammatory Bowel Disease 18, also known as ibd18, is related to inflammatory bowel disease and nut allergy. An important gene associated with Inflammatory Bowel Disease 18 is IBD18 (Inflammatory Bowel Disease-18), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. Related phenotypes are hematopoietic system and cellular

More information from OMIM: 612262 PS266600

Related Diseases for Inflammatory Bowel Disease 18

Diseases in the Inflammatory Bowel Disease family:

Inflammatory Bowel Disease 11 Inflammatory Bowel Disease 1
Inflammatory Bowel Disease 2 Inflammatory Bowel Disease 3
Inflammatory Bowel Disease 7 Inflammatory Bowel Disease 5
Inflammatory Bowel Disease 8 Inflammatory Bowel Disease 6
Inflammatory Bowel Disease 4 Inflammatory Bowel Disease 9
Inflammatory Bowel Disease 10 Inflammatory Bowel Disease 12
Inflammatory Bowel Disease 13 Inflammatory Bowel Disease 14
Inflammatory Bowel Disease 15 Inflammatory Bowel Disease 16
Inflammatory Bowel Disease 17 Inflammatory Bowel Disease 18
Inflammatory Bowel Disease 19 Inflammatory Bowel Disease 20
Inflammatory Bowel Disease 21 Inflammatory Bowel Disease 22
Inflammatory Bowel Disease 23 Inflammatory Bowel Disease 24
Inflammatory Bowel Disease 25, Autosomal Recessive Inflammatory Bowel Disease 26
Inflammatory Bowel Disease 27 Inflammatory Bowel Disease 28, Autosomal Recessive
Inflammatory Bowel Disease 29 Inflammatory Bowel Disease 30
Inflammatory Bowel Disease 28 Inflammatory Bowel Disease 25
Rare Inflammatory Bowel Disease

Diseases related to Inflammatory Bowel Disease 18 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 252)
# Related Disease Score Top Affiliating Genes
1 inflammatory bowel disease 30.3 NOD2 IL4 IL17A IL10 IBD18 CTLA4
2 nut allergy 10.4 IL4 CCR6
3 cutaneous candidiasis 10.4 IL17A CCR6
4 tropical endomyocardial fibrosis 10.3 IL4 IL10
5 suppurative lymphadenitis 10.3 PDE6B CCR6
6 acute gonococcal cervicitis 10.3 IL4 IL10
7 autoimmune lymphoproliferative syndrome, type v 10.3 CTLA4 CD28
8 palladium allergic contact dermatitis 10.2 IL17A IL10
9 cow milk allergy 10.2 IL4 IL10
10 autoimmune hepatitis type 1 10.2 IL4 IL10
11 spotted fever rickettsiosis 10.2 IL10 CTLA4
12 enterocolitis 10.2 NOD2 IL10
13 neurosyphilis 10.2 IL17A IL10
14 mikulicz disease 10.2 IL4 IL10 CCR6
15 vernal conjunctivitis 10.2 IL4 CCR6
16 loiasis 10.2 IL4 IL10
17 esophageal candidiasis 10.2 IL17A CCR6
18 egg allergy 10.2 IL4 IL10 CCR6
19 legume allergy 10.2 IL4 IL10 CCR6
20 fruit allergy 10.2 IL4 IL10 CCR6
21 chronic conjunctivitis 10.2 IL4 IL10 CCR6
22 autoimmune gastritis 10.2 IL4 IL10 CCR6
23 basidiobolomycosis 10.2 IL4 IL10
24 genital herpes 10.2 IL4 IL10 CCR6
25 nail disease 10.2 IL17A CCRL2 CCR6
26 peanut allergy 10.2 IL4 IL10 CCR6
27 respiratory allergy 10.2 IL4 IL10 CCR6
28 herpangina 10.2 IL4 IL10 CCR6
29 middle ear disease 10.2 IL4 IL10 CCR6
30 splenic disease 10.2 IL4 IL10 CCR6
31 tularemia 10.2 PDE6B IL17A CCR6
32 cerebral sinovenous thrombosis 10.2 IL17A IL10
33 subcutaneous mycosis 10.2 IL17A IL10 CCR6
34 viral pneumonia 10.2 IL17A IL10 CCR6
35 eales disease 10.2 IL4 IL10
36 klebsiella pneumonia 10.2 IL17A IL10 CCR6
37 autoimmune cardiomyopathy 10.2 CTLA4 CD28
38 transverse myelitis 10.2 IL17A IL10 CCR6
39 myelitis 10.2 IL17A IL10 CCR6
40 autoimmune disease of peripheral nervous system 10.2 IL17A IL10 CCR6
41 scleritis 10.2 IL4 CTLA4 CCR6
42 vaginal disease 10.2 IL17A IL10 CCR6
43 hypopyon 10.1 IL17A IL10
44 inflammatory bowel disease 9 10.1 NOD2 CCR6
45 evans' syndrome 10.1 IL10 CTLA4 CCR6
46 autoimmune disease of cardiovascular system 10.1 IL17A IL10 CCR6
47 meningitis 10.1 IL4 IL17A IL10
48 spinal cord disease 10.1 IL17A IL10 CCR6
49 candidiasis 10.1 IL4 IL17A IL10
50 chromium allergic contact dermatitis 10.1 IL4 IL17A IL10

Graphical network of the top 20 diseases related to Inflammatory Bowel Disease 18:



Diseases related to Inflammatory Bowel Disease 18

Symptoms & Phenotypes for Inflammatory Bowel Disease 18

Clinical features from OMIM®:

612262 (Updated 05-Mar-2021)

MGI Mouse Phenotypes related to Inflammatory Bowel Disease 18:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.33 ADAM17 ATG16L1 CCR6 CCRL2 CD247 CD28
2 cellular MP:0005384 10.26 ADAM17 ATG16L1 CCRL2 CD247 CD28 IL10
3 digestive/alimentary MP:0005381 10.23 ADAM17 ATG16L1 CD28 CTLA4 IL10 IL17A
4 immune system MP:0005387 10.22 ADAM17 ATG16L1 CCR6 CCRL2 CD247 CD28
5 endocrine/exocrine gland MP:0005379 10.21 ADAM17 ATG16L1 CD247 CD28 CTLA4 IL10
6 homeostasis/metabolism MP:0005376 10.21 ADAM17 ATG16L1 CCR6 CD28 CTLA4 IL10
7 integument MP:0010771 9.96 ADAM17 ATG16L1 CD28 CTLA4 IL10 IL17A
8 normal MP:0002873 9.9 ADAM17 CCR6 CCRL2 CD247 CD28 CTLA4
9 respiratory system MP:0005388 9.5 ADAM17 CTLA4 IL10 IL17A IL4 RAG1
10 skeleton MP:0005390 9.28 ADAM17 CTLA4 IL10 IL17A IL4 ITGB7

Drugs & Therapeutics for Inflammatory Bowel Disease 18

Search Clinical Trials , NIH Clinical Center for Inflammatory Bowel Disease 18

Genetic Tests for Inflammatory Bowel Disease 18

Genetic tests related to Inflammatory Bowel Disease 18:

# Genetic test Affiliating Genes
1 Inflammatory Bowel Disease 18 29

Anatomical Context for Inflammatory Bowel Disease 18

Publications for Inflammatory Bowel Disease 18

Articles related to Inflammatory Bowel Disease 18:

(show all 14)
# Title Authors PMID Year
1
Confirmation of multiple Crohn's disease susceptibility loci in a large Dutch-Belgian cohort. 57
19174780 2009
2
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. 57
18587394 2008
3
Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease. 57
18438406 2008
4
Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis. 57
18438405 2008
5
Systematic association mapping identifies NELL1 as a novel IBD disease gene. 57
17684544 2007
6
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. 57
17554300 2007
7
Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis. 57
17435756 2007
8
Novel Crohn disease locus identified by genome-wide association maps to a gene desert on 5p13.1 and modulates expression of PTGER4. 57
17447842 2007
9
First experience in colorectal surgery with a new robotic platform with haptic feedback. 61
28905524 2017
10
Incidence of surgical site infections postcolorectal resections without preoperative mechanical or antibiotic bowel preparation. 61
19725287 2009
11
Virtual colonoscopy vs conventional colonoscopy in patients at high risk of colorectal cancer--a prospective trial of 150 patients. 61
18462241 2009
12
Metabolic features of inflammatory bowel disease in a remission phase of the disease activity. 61
9651555 1998
13
[Coagulation changes in inflammatory intestinal disease]. 61
1546196 1992
14
Tumor necrosis factor-alpha is not elevated in children with inflammatory bowel disease. 61
2051274 1991

Variations for Inflammatory Bowel Disease 18

Expression for Inflammatory Bowel Disease 18

Search GEO for disease gene expression data for Inflammatory Bowel Disease 18.

Pathways for Inflammatory Bowel Disease 18

Pathways related to Inflammatory Bowel Disease 18 according to GeneCards Suite gene sharing:

(show all 20)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.69 RAG2 RAG1 NOD2 LTBR KLRB1 ITGB7
2
Show member pathways
13.65 ITGB7 IL4 IL17A IL10 CD28 CD247
3
Show member pathways
13.53 LTBR IL4 IL17A IL10 CD28 CD247
4
Show member pathways
13.24 ITGB7 IL4 IL17A IL10 CD28 CD247
5
Show member pathways
13.17 RAG2 RAG1 NOD2 LTBR IL4 IL17A
6
Show member pathways
12.42 IL4 IL17A IL10 CTLA4 CD28 CD247
7
Show member pathways
12.38 NOD2 IL4 IL17A IL10 CD28 CD247
8 12.31 RAG1 IL4 IL17A IL10 CTLA4 CD28
9
Show member pathways
12.3 LTBR ITGB7 IL4 IL17A IL10 CTLA4
10
Show member pathways
12.17 LTBR IL10 CCRL2 CCR6
11 11.84 KLRB1 IL4 IL10 CD28
12 11.82 IL4 IL17A IL10
13 11.72 IL17A CTLA4 CD28
14
Show member pathways
11.7 IL4 IL17A CD28
15
Show member pathways
11.61 IL17A IL10 CD28
16 11.57 CTLA4 CD28 CD247
17 11.46 KLRB1 IL4 IL17A IL10 CCR6
18 11.35 IL4 IL10 CD28
19 11.02 IL4 IL10 CD247
20 10.92 ITGB7 IL4 IL10 CTLA4 CD28 CCR6

GO Terms for Inflammatory Bowel Disease 18

Cellular components related to Inflammatory Bowel Disease 18 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.65 NOD2 ITGB7 CD28 CCR6 ADAM17
2 external side of plasma membrane GO:0009897 9.55 IL17A CTLA4 CD28 CCRL2 CCR6
3 protein complex involved in cell adhesion GO:0098636 8.96 CTLA4 CD28
4 DNA recombinase complex GO:0097519 8.62 RAG2 RAG1

Biological processes related to Inflammatory Bowel Disease 18 according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 regulation of immune response GO:0050776 9.76 KLRB1 ITGB7 IL4 CD247
2 defense response to Gram-positive bacterium GO:0050830 9.73 NOD2 IL17A ADAM17
3 negative regulation of tumor necrosis factor production GO:0032720 9.69 NOD2 IL4 IL10
4 regulation of regulatory T cell differentiation GO:0045589 9.57 CTLA4 CD28
5 regulation of T cell proliferation GO:0042129 9.55 CTLA4 CD28
6 positive regulation of MHC class II biosynthetic process GO:0045348 9.54 IL4 IL10
7 positive regulation of interleukin-10 production GO:0032733 9.54 NOD2 IL4 CD28
8 V(D)J recombination GO:0033151 9.52 RAG2 RAG1
9 positive regulation of isotype switching to IgG isotypes GO:0048304 9.49 IL4 CD28
10 T cell migration GO:0072678 9.48 ITGB7 CCR6
11 type 2 immune response GO:0042092 9.43 IL4 IL10
12 negative regulation of interleukin-18 production GO:0032701 9.4 NOD2 IL10
13 B cell differentiation GO:0030183 9.35 RAG2 RAG1 IL4 IL10 ADAM17
14 T cell differentiation in thymus GO:0033077 9.33 RAG2 RAG1 ADAM17
15 regulation of isotype switching GO:0045191 9.32 IL4 IL10
16 immune response GO:0006955 9.28 RAG1 LTBR IL4 IL17A IL10 CTLA4
17 pre-B cell allelic exclusion GO:0002331 9.26 RAG2 RAG1

Sources for Inflammatory Bowel Disease 18

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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