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IBD2
MCID: INF078
MIFTS: 29

Inflammatory Bowel Disease 2 (IBD2)

Categories: Blood diseases, Bone diseases, Gastrointestinal diseases, Genetic diseases, Immune diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Inflammatory Bowel Disease 2

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MalaCards integrated aliases for Inflammatory Bowel Disease 2:

Name: Inflammatory Bowel Disease 2 56 12 13 15 71
Ibd2 56 12

Classifications:

MalaCards categories:
Global: Genetic diseases Rare diseases
Anatomical: Gastrointestinal diseases Bone diseases Blood diseases Immune diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:0110900
OMIM 56 601458
OMIM Phenotypic Series 56 PS266600
UMLS 71 C1832321
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Summaries for Inflammatory Bowel Disease 2

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Disease Ontology : 12 An inflammatory bowel disease that has material basis in variation in the chromosome region 12p13.2-q24.1.

MalaCards based summary : Inflammatory Bowel Disease 2, also known as ibd2, is related to inflammatory bowel disease 6 and crohn's disease. An important gene associated with Inflammatory Bowel Disease 2 is IBD2 (Inflammatory Bowel Disease 2), and among its related pathways/superpathways is Ovarian tumor domain proteases. The drugs leucovorin and Zinc have been mentioned in the context of this disorder. Affiliated tissues include colon and neutrophil.

More information from OMIM: 601458 PS266600
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Related Diseases for Inflammatory Bowel Disease 2

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Diseases in the Inflammatory Bowel Disease family:

Inflammatory Bowel Disease 11 Inflammatory Bowel Disease 1
Inflammatory Bowel Disease 2 Inflammatory Bowel Disease 3
Inflammatory Bowel Disease 7 Inflammatory Bowel Disease 5
Inflammatory Bowel Disease 8 Inflammatory Bowel Disease 6
Inflammatory Bowel Disease 4 Inflammatory Bowel Disease 9
Inflammatory Bowel Disease 10 Inflammatory Bowel Disease 12
Inflammatory Bowel Disease 13 Inflammatory Bowel Disease 14
Inflammatory Bowel Disease 15 Inflammatory Bowel Disease 16
Inflammatory Bowel Disease 17 Inflammatory Bowel Disease 18
Inflammatory Bowel Disease 19 Inflammatory Bowel Disease 20
Inflammatory Bowel Disease 21 Inflammatory Bowel Disease 22
Inflammatory Bowel Disease 23 Inflammatory Bowel Disease 24
Inflammatory Bowel Disease 25, Autosomal Recessive Inflammatory Bowel Disease 26
Inflammatory Bowel Disease 27 Inflammatory Bowel Disease 28, Autosomal Recessive
Inflammatory Bowel Disease 29 Inflammatory Bowel Disease 28
Inflammatory Bowel Disease 25 Rare Inflammatory Bowel Disease

Diseases related to Inflammatory Bowel Disease 2 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 14)
# Related Disease Score Top Affiliating Genes
1 inflammatory bowel disease 6 30.0 PPM1L NOD2 ATG16L1
2 crohn's disease 29.8 NOD2 NKX2-3 ATG16L1
3 inflammatory bowel disease 29.6 STAT6 NOD2 NKX2-3 IBD2 ATG16L1
4 crohn's colitis 29.5 NOD2 ATG16L1
5 inflammatory bowel disease 3 28.7 TMEM183A PPP2R2C PPM1L NOD2 HOGA1
6 colitis 10.3
7 inflammatory bowel disease 4 10.2 PPM1L NOD2
8 inflammatory bowel disease 9 10.0 RNF186 NOD2
9 ulcerative colitis 10.0
10 ileocolitis 10.0 NOD2 ATG16L1
11 ileitis 9.7 NOD2 ATG16L1
12 inflammatory bowel disease 1 9.6 PPM1L NOD2 NKX2-3 ATG16L1
13 inflammatory bowel disease 5 9.5 RNF186 NOD2 NKX2-3 ATG16L1
14 inflammatory bowel disease 7 9.2 TMEM183A PPP2R2C PPM1L NOD2

Graphical network of the top 20 diseases related to Inflammatory Bowel Disease 2:



Diseases related to Inflammatory Bowel Disease 2
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Symptoms & Phenotypes for Inflammatory Bowel Disease 2

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Clinical features from OMIM:

601458
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Drugs & Therapeutics for Inflammatory Bowel Disease 2

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Drugs for Inflammatory Bowel Disease 2 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
leucovorin Approved Phase 4 58-05-9 6006 143
2
Zinc Approved, Investigational Phase 4 7440-66-6 32051
3
Tocopherol Approved, Investigational Phase 4 1406-66-2, 54-28-4 14986
4
Copper Approved, Investigational Phase 4 7440-50-8 27099
5
Folic acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
6
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4 59-02-9 14985
7
Vitamin C Approved, Nutraceutical Phase 4 50-81-7 5785 54670067
8 Tocotrienol Investigational Phase 4 6829-55-6
9 Vitamins Phase 4
10 Vitamin B Complex Phase 4
11 Copper Supplement Phase 4
12 Antioxidants Phase 4
13 Iron Supplement Phase 4
14 Folate Phase 4
15 Tocopherols Phase 4
16 Tocotrienols Phase 4
17 Vitamin B9 Phase 4
18
Iron Approved, Experimental Phase 2 15438-31-0, 7439-89-6 27284 23925
19 Cola Phase 2
20 Hematinics Phase 2
21 Ferric Compounds Phase 2
22
Tyrosine Approved, Investigational, Nutraceutical 60-18-4 6057

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Randomized Cross-Over Trial of Captafer® vs. Oral Iron Sulfate in the Treatment of Iron Deficiency Anemia in Patients With Inflammatory Bowel Disease Unknown status NCT02774057 Phase 4 Captafer®;Iron Sulfate
2 Detection and Classification of Colon Polyps: A Comparison of High Definition White Light and Narrow Band Imaging (Endoscopic Trimodal Imaging; ETMI) Completed NCT00825292 Phase 2
3 A Multi-centre, Randomized, Controlled, Single-blinded, Phase II Study to Investigate the Safety and Efficacy of Intravenous Infusions of FERINJECT® Versus Placebo in Patients With Thrombocytosis Secondary to Iron Deficiency and Chronic Inflammatory Bowel Disease Terminated NCT00882414 Phase 2 FERINJECT® (Ferric carboxymaltose);Placebo
4 Golimumab Effect in the Modulation of Gut Microbiota in Ulcerative Colitis: Pilot Study Unknown status NCT03018925 Golimumab
5 Association Between Helicobacter Pylori and Inflammatory Bowel Disease Recruiting NCT03820284
6 Receptor for Advanced Glycation End Products (RAGE) Polymorphisms In Inflammatory Bowel Disease Not yet recruiting NCT04286659
7 Lymphoid Tyrosine Phosphatase Gene Polymorphisms in Inflammatory Bowel Disease Not yet recruiting NCT04284878

Search NIH Clinical Center for Inflammatory Bowel Disease 2

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Genetic Tests for Inflammatory Bowel Disease 2

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Anatomical Context for Inflammatory Bowel Disease 2

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MalaCards organs/tissues related to Inflammatory Bowel Disease 2:

40
Colon, Neutrophil
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Publications for Inflammatory Bowel Disease 2

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Articles related to Inflammatory Bowel Disease 2:

(show top 50) (show all 73)
# Title Authors PMID Year
1
International collaboration provides convincing linkage replication in complex disease through analysis of a large pooled data set: Crohn disease and chromosome 16. 56 61
11309682 2001
2
The IBD2 locus shows linkage heterogeneity between ulcerative colitis and Crohn disease. 61 56
11078482 2000
3
Additional evidence of linkage between Crohn's disease and a putative locus on chromosome 12. 56
11256672 1999
4
Linkage and association between inflammatory bowel disease and a locus on chromosome 12. 56
9634527 1998
5
Two stage genome-wide search in inflammatory bowel disease provides evidence for susceptibility loci on chromosomes 3, 7 and 12. 56
8841195 1996
6
Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. 56
7581446 1995
7
Rapid, Phase-free Detection of Long Identity-by-Descent Segments Enables Effective Relationship Classification. 61
32197076 2020
8
Communication and management of incidental pathology in 1,214 consecutive appendicectomies; a cohort study. 61
31683040 2019
9
A blood-based prognostic biomarker in IBD. 61
31030191 2019
10
Psychological interventions for parents of children and adolescents with chronic illness. 61
30883665 2019
11
Phytofiltration of anaerobically digested sugarcane ethanol stillage using a macrophyte with high potential for biofuel production. 61
29775098 2018
12
Profile of renal AA amyloidosis in older and younger individuals: a single-centre experience. 61
29775082 2018
13
Retrospective evaluation of the clinical utility of serological biomarkers in Chinese patients with inflammatory bowel disease: 2-year clinical experience. 61
27831916 2017
14
Protective Effect of Protocatechuic Acid on TNBS-Induced Colitis in Mice Is Associated with Modulation of the SphK/S1P Signaling Pathway. 61
28300788 2017
15
Microscopic colitis in patients with mild duodenal damage: A new clinical and pathological entity ("lymphocytic enterocolitis")? 61
27895976 2016
16
Ipilimumab Therapy in Patients With Advanced Melanoma and Preexisting Autoimmune Disorders. 61
26633184 2016
17
[Portuguese Consensus on the Diagnosis, Prevention and Treatment of Anaemia in Inflammatory Bowel Disease]. 61
27234956 2016
18
Anemia in inflammatory bowel disease: prevalence, differential diagnosis and association with clinical and laboratory variables. 61
24760213 2014
19
[Vasculitis in Sweet's Syndrome]. 61
22987379 2012
20
Single nucleotide polymorphisms in C-type lectin genes, clustered in the IBD2 and IBD6 susceptibility loci, may play a role in the pathogenesis of inflammatory bowel diseases. 61
22664939 2012
21
Consanguinity in Centre d'Étude du Polymorphisme Humain (CEPH) pedigrees. 61
22274586 2012
22
Prediction of late-onset pouch failure in patients with restorative proctocolectomy with a nomogram. 61
22325174 2012
23
Unexpected relationships and inbreeding in HapMap phase III populations. 61
23185369 2012
24
Inference of relationships in population data using identity-by-descent and identity-by-state. 61
21966277 2011
25
Identity-by-descent filtering of exome sequence data for disease-gene identification in autosomal recessive disorders. 61
21278187 2011
26
A prospective study into the aetiology of lymphocytic duodenosis. 61
21050242 2010
27
Safety and efficacy of double-balloon enteroscopy in pediatric patients. 61
19913784 2010
28
Preventing recurrent venous thromboembolism. 61
19357297 2009
29
[Diagnosis of inflammatory bowel disease. 2. X-ray and endoscopic diagnosis]. 61
19334354 2009
30
Analysis of germline GLI1 variation implicates hedgehog signalling in the regulation of intestinal inflammatory pathways. 61
19071955 2008
31
Regional variation in gene expression in the healthy colon is dysregulated in ulcerative colitis. 61
18523026 2008
32
Influence of interbracket distances on the resistance to sliding of orthodontic appliances. 61
17826605 2007
33
Distribution of signal transducer and activator of transcription 6 gene G2964A polymorphism in Chinese patients with ulcerative colitis. 61
17074026 2006
34
Vitamin D status in children and young adults with inflammatory bowel disease. 61
17079566 2006
35
Identification of genetic loci for basal cell nevus syndrome and inflammatory bowel disease in a single large pedigree. 61
16733713 2006
36
Phenotype-stratified genetic linkage study demonstrates that IBD2 is an extensive ulcerative colitis locus. 61
16542294 2006
37
The G2964A polymorphism of the STAT6 gene in inflammatory bowel disease. 61
15888279 2005
38
Characterization of genotype-phenotype relationships and stratification by the CARD15 variant genotype for inflammatory bowel disease susceptibility loci using multiple short tandem repeat genetic markers. 61
15643611 2005
39
A genome scan in 260 inflammatory bowel disease-affected relative pairs. 61
15472510 2004
40
[Genetics of inflammatory bowel disease]. 61
15552020 2004
41
Genome wide scan in a Flemish inflammatory bowel disease population: support for the IBD4 locus, population heterogeneity, and epistasis. 61
15194648 2004
42
Absence of an association of the IBD2 locus gene keratin 8 and inflammatory bowel disease in a large genetic association study. 61
15248376 2004
43
No evidence for involvement of IL-4R and CD11B from the IBD1 region and STAT6 in the IBD2 region in Crohn's disease. 61
14571275 2003
44
Signal transducer and activator of transcription 6 gene G2964A polymorphism and inflammatory bowel disease. 61
12605697 2003
45
The genetics of inflammatory bowel disease. 61
12557156 2003
46
Association of ulcerative colitis with the inflammatory bowel disease susceptibility locus IBD2 in non-Jewish Caucasians and evidence of genetic heterogeneity among racial and ethnic populations with Crohn disease. 61
12439891 2002
47
Genetically determined differences in P-glycoprotein function: implications for disease risk. 61
12505329 2002
48
IBD2 encodes a novel component of the Bub2p-dependent spindle checkpoint in the budding yeast Saccharomyces cerevisiae. 61
12072457 2002
49
Genomic structure, chromosome mapping and expression analysis of the human AVIL gene, and its exclusion as a candidate for locus for inflammatory bowel disease at 12q13-14 (IBD2). 61
12034507 2002
50
Sex stratification of an inflammatory bowel disease genome search shows male-specific linkage to the HLA region of chromosome 6. 61
12032734 2002
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Variations for Inflammatory Bowel Disease 2

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Expression for Inflammatory Bowel Disease 2

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Search GEO for disease gene expression data for Inflammatory Bowel Disease 2.
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Pathways for Inflammatory Bowel Disease 2

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Pathways related to Inflammatory Bowel Disease 2 according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Ovarian tumor domain proteases 65
10.19 TNIP3 NOD2
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GO Terms for Inflammatory Bowel Disease 2

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Sources for Inflammatory Bowel Disease 2

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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