IBD2
MCID: INF078
MIFTS: 29

Inflammatory Bowel Disease 2 (IBD2)

Categories: Blood diseases, Bone diseases, Gastrointestinal diseases, Genetic diseases, Immune diseases, Rare diseases

Aliases & Classifications for Inflammatory Bowel Disease 2

MalaCards integrated aliases for Inflammatory Bowel Disease 2:

Name: Inflammatory Bowel Disease 2 57 12 13 15 72
Ibd2 57 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0110900
UMLS 72 C1832321

Summaries for Inflammatory Bowel Disease 2

Disease Ontology : 12 An inflammatory bowel disease that has material basis in variation in the chromosome region 12p13.2-q24.1.

MalaCards based summary : Inflammatory Bowel Disease 2, also known as ibd2, is related to inflammatory bowel disease and inflammatory bowel disease 3. An important gene associated with Inflammatory Bowel Disease 2 is IBD2 (Inflammatory Bowel Disease 2). The drugs leucovorin and Tocopherol have been mentioned in the context of this disorder. Affiliated tissues include colon and neutrophil, and related phenotype is renal/urinary system.

More information from OMIM: 601458 PS266600

Related Diseases for Inflammatory Bowel Disease 2

Diseases in the Inflammatory Bowel Disease family:

Inflammatory Bowel Disease 11 Inflammatory Bowel Disease 1
Inflammatory Bowel Disease 2 Inflammatory Bowel Disease 3
Inflammatory Bowel Disease 7 Inflammatory Bowel Disease 5
Inflammatory Bowel Disease 8 Inflammatory Bowel Disease 6
Inflammatory Bowel Disease 4 Inflammatory Bowel Disease 9
Inflammatory Bowel Disease 10 Inflammatory Bowel Disease 12
Inflammatory Bowel Disease 13 Inflammatory Bowel Disease 14
Inflammatory Bowel Disease 15 Inflammatory Bowel Disease 16
Inflammatory Bowel Disease 17 Inflammatory Bowel Disease 18
Inflammatory Bowel Disease 19 Inflammatory Bowel Disease 20
Inflammatory Bowel Disease 21 Inflammatory Bowel Disease 22
Inflammatory Bowel Disease 23 Inflammatory Bowel Disease 24
Inflammatory Bowel Disease 25, Autosomal Recessive Inflammatory Bowel Disease 26
Inflammatory Bowel Disease 27 Inflammatory Bowel Disease 28, Autosomal Recessive
Inflammatory Bowel Disease 29 Inflammatory Bowel Disease 28
Inflammatory Bowel Disease 25 Rare Inflammatory Bowel Disease

Diseases related to Inflammatory Bowel Disease 2 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 11)
# Related Disease Score Top Affiliating Genes
1 inflammatory bowel disease 30.2 STAT6 NOD2
2 inflammatory bowel disease 3 29.8 NOD2 HOGA1
3 crohn's disease 28.9 NOD2 DLG5
4 colitis 10.3
5 inflammatory bowel disease 6 10.2
6 inflammatory bowel disease 4 9.9 NOD2 HOGA1
7 crohn's colitis 9.8
8 ulcerative colitis 9.8
9 inflammatory bowel disease 1 9.8 NOD2 HOGA1
10 inflammatory bowel disease 5 9.6 NOD2 DLG5
11 ileocolitis 9.6 NOD2 DLG5

Graphical network of the top 20 diseases related to Inflammatory Bowel Disease 2:



Diseases related to Inflammatory Bowel Disease 2

Symptoms & Phenotypes for Inflammatory Bowel Disease 2

Clinical features from OMIM:

601458

MGI Mouse Phenotypes related to Inflammatory Bowel Disease 2:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 renal/urinary system MP:0005367 8.92 DLG5 HOGA1 HOXA13 STAT6

Drugs & Therapeutics for Inflammatory Bowel Disease 2

Drugs for Inflammatory Bowel Disease 2 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 27)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
leucovorin Approved Phase 4 58-05-9 143 6006
2
Tocopherol Approved, Investigational Phase 4 1406-66-2, 54-28-4 14986
3
Copper Approved, Investigational Phase 4 7440-50-8 27099
4
Zinc Approved, Investigational Phase 4 7440-66-6 32051
5
Folic acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
6
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4 59-02-9 14985
7
Vitamin C Approved, Nutraceutical Phase 4 50-81-7 54670067 5785
8 Tocotrienol Investigational Phase 4 6829-55-6
9 Antioxidants Phase 4
10 Vitamins Phase 4
11 Tocotrienols Phase 4
12 Vitamin B9 Phase 4
13 Tocopherols Phase 4
14 Vitamin B Complex Phase 4
15 Iron Supplement Phase 4
16 Nutrients Phase 4
17 Folate Phase 4
18 Micronutrients Phase 4
19 Trace Elements Phase 4
20
Iron Approved, Experimental Phase 2 15438-31-0, 7439-89-6 23925 27284
21 Cola Phase 2
22 Hematinics Phase 2
23 Ferric Compounds Phase 2
24 Antibodies
25 Immunologic Factors
26 Antibodies, Monoclonal
27 Immunoglobulins

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Randomized Cross-Over Trial of Captafer® vs. Oral Iron Sulfate in the Treatment of Iron Deficiency Anemia in Patients With Inflammatory Bowel Disease Unknown status NCT02774057 Phase 4 Captafer®;Iron Sulfate
2 Detection and Classification of Colon Polyps: A Comparison of High Definition White Light and Narrow Band Imaging (Endoscopic Trimodal Imaging; ETMI) Completed NCT00825292 Phase 2
3 A Multi-centre, Randomized, Controlled, Single-blinded, Phase II Study to Investigate the Safety and Efficacy of Intravenous Infusions of FERINJECT® Versus Placebo in Patients With Thrombocytosis Secondary to Iron Deficiency and Chronic Inflammatory Bowel Disease Terminated NCT00882414 Phase 2 FERINJECT® (Ferric carboxymaltose);Placebo
4 Golimumab Effect in the Modulation of Gut Microbiota in Ulcerative Colitis: Pilot Study Unknown status NCT03018925 Golimumab
5 Association Between Helicobacter Pylori and Inflammatory Bowel Disease Recruiting NCT03820284

Search NIH Clinical Center for Inflammatory Bowel Disease 2

Genetic Tests for Inflammatory Bowel Disease 2

Anatomical Context for Inflammatory Bowel Disease 2

MalaCards organs/tissues related to Inflammatory Bowel Disease 2:

41
Colon, Neutrophil

Publications for Inflammatory Bowel Disease 2

Articles related to Inflammatory Bowel Disease 2:

(show top 50) (show all 71)
# Title Authors PMID Year
1
International collaboration provides convincing linkage replication in complex disease through analysis of a large pooled data set: Crohn disease and chromosome 16. 38 8
11309682 2001
2
The IBD2 locus shows linkage heterogeneity between ulcerative colitis and Crohn disease. 38 8
11078482 2000
3
Additional evidence of linkage between Crohn's disease and a putative locus on chromosome 12. 8
11256672 1999
4
Linkage and association between inflammatory bowel disease and a locus on chromosome 12. 8
9634527 1998
5
Two stage genome-wide search in inflammatory bowel disease provides evidence for susceptibility loci on chromosomes 3, 7 and 12. 8
8841195 1996
6
Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. 8
7581446 1995
7
A blood-based prognostic biomarker in IBD. 38
31030191 2019
8
Psychological interventions for parents of children and adolescents with chronic illness. 38
30883665 2019
9
Phytofiltration of anaerobically digested sugarcane ethanol stillage using a macrophyte with high potential for biofuel production. 38
29775098 2018
10
Profile of renal AA amyloidosis in older and younger individuals: a single-centre experience. 38
29775082 2018
11
Retrospective evaluation of the clinical utility of serological biomarkers in Chinese patients with inflammatory bowel disease: 2-year clinical experience. 38
27831916 2017
12
Protective Effect of Protocatechuic Acid on TNBS-Induced Colitis in Mice Is Associated with Modulation of the SphK/S1P Signaling Pathway. 38
28300788 2017
13
Microscopic colitis in patients with mild duodenal damage: A new clinical and pathological entity ("lymphocytic enterocolitis")? 38
27895976 2016
14
Ipilimumab Therapy in Patients With Advanced Melanoma and Preexisting Autoimmune Disorders. 38
26633184 2016
15
[Portuguese Consensus on the Diagnosis, Prevention and Treatment of Anaemia in Inflammatory Bowel Disease]. 38
27234956 2016
16
Anemia in inflammatory bowel disease: prevalence, differential diagnosis and association with clinical and laboratory variables. 38
24760213 2014
17
[Vasculitis in Sweet's Syndrome]. 38
22987379 2012
18
Single nucleotide polymorphisms in C-type lectin genes, clustered in the IBD2 and IBD6 susceptibility loci, may play a role in the pathogenesis of inflammatory bowel diseases. 38
22664939 2012
19
Consanguinity in Centre d'Étude du Polymorphisme Humain (CEPH) pedigrees. 38
22274586 2012
20
Prediction of late-onset pouch failure in patients with restorative proctocolectomy with a nomogram. 38
22325174 2012
21
Unexpected relationships and inbreeding in HapMap phase III populations. 38
23185369 2012
22
Inference of relationships in population data using identity-by-descent and identity-by-state. 38
21966277 2011
23
Identity-by-descent filtering of exome sequence data for disease-gene identification in autosomal recessive disorders. 38
21278187 2011
24
A prospective study into the aetiology of lymphocytic duodenosis. 38
21050242 2010
25
Safety and efficacy of double-balloon enteroscopy in pediatric patients. 38
19913784 2010
26
Preventing recurrent venous thromboembolism. 38
19357297 2009
27
[Diagnosis of inflammatory bowel disease. 2. X-ray and endoscopic diagnosis]. 38
19334354 2009
28
Analysis of germline GLI1 variation implicates hedgehog signalling in the regulation of intestinal inflammatory pathways. 38
19071955 2008
29
Regional variation in gene expression in the healthy colon is dysregulated in ulcerative colitis. 38
18523026 2008
30
Influence of interbracket distances on the resistance to sliding of orthodontic appliances. 38
17826605 2007
31
Distribution of signal transducer and activator of transcription 6 gene G2964A polymorphism in Chinese patients with ulcerative colitis. 38
17074026 2006
32
Vitamin D status in children and young adults with inflammatory bowel disease. 38
17079566 2006
33
Identification of genetic loci for basal cell nevus syndrome and inflammatory bowel disease in a single large pedigree. 38
16733713 2006
34
Phenotype-stratified genetic linkage study demonstrates that IBD2 is an extensive ulcerative colitis locus. 38
16542294 2006
35
The G2964A polymorphism of the STAT6 gene in inflammatory bowel disease. 38
15888279 2005
36
Characterization of genotype-phenotype relationships and stratification by the CARD15 variant genotype for inflammatory bowel disease susceptibility loci using multiple short tandem repeat genetic markers. 38
15643611 2005
37
A genome scan in 260 inflammatory bowel disease-affected relative pairs. 38
15472510 2004
38
Genome wide scan in a Flemish inflammatory bowel disease population: support for the IBD4 locus, population heterogeneity, and epistasis. 38
15194648 2004
39
[Genetics of inflammatory bowel disease]. 38
15552020 2004
40
Absence of an association of the IBD2 locus gene keratin 8 and inflammatory bowel disease in a large genetic association study. 38
15248376 2004
41
No evidence for involvement of IL-4R and CD11B from the IBD1 region and STAT6 in the IBD2 region in Crohn's disease. 38
14571275 2003
42
Signal transducer and activator of transcription 6 gene G2964A polymorphism and inflammatory bowel disease. 38
12605697 2003
43
The genetics of inflammatory bowel disease. 38
12557156 2003
44
Association of ulcerative colitis with the inflammatory bowel disease susceptibility locus IBD2 in non-Jewish Caucasians and evidence of genetic heterogeneity among racial and ethnic populations with Crohn disease. 38
12439891 2002
45
Genetically determined differences in P-glycoprotein function: implications for disease risk. 38
12505329 2002
46
IBD2 encodes a novel component of the Bub2p-dependent spindle checkpoint in the budding yeast Saccharomyces cerevisiae. 38
12072457 2002
47
Genomic structure, chromosome mapping and expression analysis of the human AVIL gene, and its exclusion as a candidate for locus for inflammatory bowel disease at 12q13-14 (IBD2). 38
12034507 2002
48
Sex stratification of an inflammatory bowel disease genome search shows male-specific linkage to the HLA region of chromosome 6. 38
12032734 2002
49
Replication and extension studies of inflammatory bowel disease susceptibility regions confirm linkage to chromosome 6p (IBD3). 38
11528509 2001
50
[Clinical features of spondyloarthropaties in childhood: analysis of 26 patients]. 38
11723501 2001

Variations for Inflammatory Bowel Disease 2

Expression for Inflammatory Bowel Disease 2

Search GEO for disease gene expression data for Inflammatory Bowel Disease 2.

Pathways for Inflammatory Bowel Disease 2

GO Terms for Inflammatory Bowel Disease 2

Sources for Inflammatory Bowel Disease 2

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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