Inflammatory Bowel Disease 2 disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Inflammatory Bowel Disease 2

MalaCards integrated aliases for Inflammatory Bowel Disease 2:

Name: Inflammatory Bowel Disease 2 ⁵⁷ ¹² ¹³ ¹⁵ ⁷³

Ibd2 ⁵⁷ ¹²

Classifications:

MalaCards categories:
Global: Genetic diseases Rare diseases
Anatomical: Gastrointestinal diseases Bone diseases Blood diseases Immune diseases

See all MalaCards categories (disease lists)

External Ids:

OMIM ⁵⁷ 601458

Disease Ontology ¹² DOID:0110900

UMLS ⁷³ C1832321

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Summaries for Inflammatory Bowel Disease 2

Disease Ontology : ¹² An inflammatory bowel disease that has material basis in variation in the chromosome region 12p13.2-q24.1.

MalaCards based summary : Inflammatory Bowel Disease 2, also known as ibd2, is related to inflammatory bowel disease and crohn's disease. An important gene associated with Inflammatory Bowel Disease 2 is IBD2 (Inflammatory Bowel Disease 2). Affiliated tissues include bone and colon, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Description from OMIM: 601458

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Related Diseases for Inflammatory Bowel Disease 2

Diseases in the Inflammatory Bowel Disease family:

Inflammatory Bowel Disease 11	Inflammatory Bowel Disease 1
Inflammatory Bowel Disease 2	Inflammatory Bowel Disease 3
Inflammatory Bowel Disease 7	Inflammatory Bowel Disease 5
Inflammatory Bowel Disease 8	Inflammatory Bowel Disease 6
Inflammatory Bowel Disease 4	Inflammatory Bowel Disease 9
Inflammatory Bowel Disease 10	Inflammatory Bowel Disease 12
Inflammatory Bowel Disease 13	Inflammatory Bowel Disease 14
Inflammatory Bowel Disease 15	Inflammatory Bowel Disease 16
Inflammatory Bowel Disease 17	Inflammatory Bowel Disease 18
Inflammatory Bowel Disease 19	Inflammatory Bowel Disease 20
Inflammatory Bowel Disease 21	Inflammatory Bowel Disease 22
Inflammatory Bowel Disease 23	Inflammatory Bowel Disease 24
Inflammatory Bowel Disease 25, Autosomal Recessive	Inflammatory Bowel Disease 26
Inflammatory Bowel Disease 27	Inflammatory Bowel Disease 28, Autosomal Recessive
Inflammatory Bowel Disease 29	Inflammatory Bowel Disease 28
Inflammatory Bowel Disease 25

Diseases related to Inflammatory Bowel Disease 2 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 11)

#	Related Disease	Score	Top Affiliating Genes
1	inflammatory bowel disease	29.4	STAT6 NOD2 IBD2 DLG5
2	crohn's disease	29.2	DLG5 NOD2
3	perrault syndrome 1	11.1
4	ulcerative colitis	10.3
5	colitis	10.3
6	crohn's colitis	10.0
7	inflammatory bowel disease 4	10.0	NOD2 HOGA1
8	inflammatory bowel disease 1	9.9	NOD2 HOGA1
9	inflammatory bowel disease 3	9.9	NOD2 HOGA1
10	inflammatory bowel disease 5	9.8	NOD2 DLG5
11	ileocolitis	9.8	NOD2 DLG5

Graphical network of the top 20 diseases related to Inflammatory Bowel Disease 2:

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Symptoms & Phenotypes for Inflammatory Bowel Disease 2

Clinical features from OMIM:

601458

GenomeRNAi Phenotypes related to Inflammatory Bowel Disease 2 according to GeneCards Suite gene sharing:

²⁶ (show all 22)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased shRNA abundance (Z-score > 2)	GR00366-A-105	10.17	DLG5
2	Increased shRNA abundance (Z-score > 2)	GR00366-A-107	10.17	DLG5
3	Increased shRNA abundance (Z-score > 2)	GR00366-A-146	10.17	DLG5
4	Increased shRNA abundance (Z-score > 2)	GR00366-A-16	10.17	DLG5
5	Increased shRNA abundance (Z-score > 2)	GR00366-A-168	10.17	DLG5
6	Increased shRNA abundance (Z-score > 2)	GR00366-A-174	10.17	NOD2
7	Increased shRNA abundance (Z-score > 2)	GR00366-A-177	10.17	HOXA13 STAT6 NOD2
8	Increased shRNA abundance (Z-score > 2)	GR00366-A-178	10.17	HOXA13
9	Increased shRNA abundance (Z-score > 2)	GR00366-A-189	10.17	STAT6
10	Increased shRNA abundance (Z-score > 2)	GR00366-A-19	10.17	HOXA13 NOD2
11	Increased shRNA abundance (Z-score > 2)	GR00366-A-192	10.17	NOD2
12	Increased shRNA abundance (Z-score > 2)	GR00366-A-195	10.17	HOXA13 NOD2 DLG5
13	Increased shRNA abundance (Z-score > 2)	GR00366-A-201	10.17	STAT6
14	Increased shRNA abundance (Z-score > 2)	GR00366-A-210	10.17	HOXA13 NOD2
15	Increased shRNA abundance (Z-score > 2)	GR00366-A-214	10.17	DLG5
16	Increased shRNA abundance (Z-score > 2)	GR00366-A-30	10.17	DLG5
17	Increased shRNA abundance (Z-score > 2)	GR00366-A-36	10.17	NOD2
18	Increased shRNA abundance (Z-score > 2)	GR00366-A-39	10.17	HOXA13 STAT6
19	Increased shRNA abundance (Z-score > 2)	GR00366-A-43	10.17	STAT6 NOD2
20	Increased shRNA abundance (Z-score > 2)	GR00366-A-54	10.17	STAT6
21	Increased shRNA abundance (Z-score > 2)	GR00366-A-74	10.17	STAT6
22	Increased shRNA abundance (Z-score > 2)	GR00366-A-81	10.17	DLG5

MGI Mouse Phenotypes related to Inflammatory Bowel Disease 2:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	renal/urinary system	MP:0005367	8.92	DLG5 HOGA1 HOXA13 STAT6

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Drugs & Therapeutics for Inflammatory Bowel Disease 2

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Anti Tumor Necrosis Factor Alpha Agents and Surgical Stress Response	Completed	NCT01974869		Anti-tumor necrosis factor alpha agents

Search NIH Clinical Center for Inflammatory Bowel Disease 2

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Genetic Tests for Inflammatory Bowel Disease 2

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Anatomical Context for Inflammatory Bowel Disease 2

MalaCards organs/tissues related to Inflammatory Bowel Disease 2:

⁴¹

Bone, Colon

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Publications for Inflammatory Bowel Disease 2

Articles related to Inflammatory Bowel Disease 2:

#	Title	Authors	Year
1	Retrospective evaluation of the clinical utility of serological biomarkers in Chinese patients with inflammatory bowel disease: 2-year clinical experience. ( 27831916 )		2016
2	Phenotype-stratified genetic linkage study demonstrates that IBD2 is an extensive ulcerative colitis locus. ( 16542294 )	Achkar JP...Nicolae DL	2006
3	Absence of an association of the IBD2 locus gene keratin 8 and inflammatory bowel disease in a large genetic association study. ( 15248376 )	de Jong DJ...Drenth JP	2004
4	IBD2 encodes a novel component of the Bub2p-dependent spindle checkpoint in the budding yeast Saccharomyces cerevisiae. ( 12072457 )	Hwang HS...Song K	2002
5	The IBD2 locus shows linkage heterogeneity between ulcerative colitis and Crohn disease. ( 11078482 )	Parkes M...Duerr RH	2000
6	Inflammatory bowel disease. 2: Medical and surgical treatment. ( 10711015 )		1999
7	Identification of multiple candidate genes for IBD susceptibility using high-density transcript mapping in the IBD2 locus on chromosome 12q. ( 10576977 )	Hamlin PJ...Robinson PA	1999
8	Inflammatory bowel disease. 2. Current and future therapeutic options. ( 9590988 )	Moses P.L....Vecchio J.A.	1998
9	Pathogenic factors in inflammatory bowel disease. 2. Crohn's disease. ( 1591873 )	Pavli P....Gibson P.R.	1992
10	Inflammatory bowel disease (2) ( 1886623 )		1991

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Genes for Inflammatory Bowel Disease 2

Genes related to Inflammatory Bowel Disease 2 (1 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	IBD2	Inflammatory Bowel Disease 2	Genetic Locus	58.46	Susceptibility factor ⁵⁷ GeneCards inferred via : Gene name (show sections)
2	HOGA1	4-Hydroxy-2-Oxoglutarate Aldolase 1	Protein Coding	16.72	DISEASES inferred ¹⁵
3	NOD2	Nucleotide Binding Oligomerization Domain Containing 2	Protein Coding	16.37	DISEASES inferred ¹⁵
4	STAT6	Signal Transducer And Activator Of Transcription 6	Protein Coding	15.63	DISEASES inferred ¹⁵
5	DLG5	Discs Large MAGUK Scaffold Protein 5	Protein Coding	15.39	DISEASES inferred ¹⁵
6	HOXA13	Homeobox A13	Protein Coding	15.08	DISEASES inferred ¹⁵

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Variations for Inflammatory Bowel Disease 2

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Expression for Inflammatory Bowel Disease 2

Search GEO for disease gene expression data for Inflammatory Bowel Disease 2.

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Pathways for Inflammatory Bowel Disease 2

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GO Terms for Inflammatory Bowel Disease 2

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Sources for Inflammatory Bowel Disease 2

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⁷⁶ Wikipedia

Inflammatory Bowel Disease 2 (IBD2)

Aliases & Classifications for Inflammatory Bowel Disease 2

MalaCards integrated aliases for Inflammatory Bowel Disease 2:

Classifications:

External Ids:

Summaries for Inflammatory Bowel Disease 2

Related Diseases for Inflammatory Bowel Disease 2

Diseases in the Inflammatory Bowel Disease family:

Diseases related to Inflammatory Bowel Disease 2 via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to Inflammatory Bowel Disease 2:

Symptoms & Phenotypes for Inflammatory Bowel Disease 2

Clinical features from OMIM:

GenomeRNAi Phenotypes related to Inflammatory Bowel Disease 2 according to GeneCards Suite gene sharing:

MGI Mouse Phenotypes related to Inflammatory Bowel Disease 2:

Drugs & Therapeutics for Inflammatory Bowel Disease 2

Interventional clinical trials:

Genetic Tests for Inflammatory Bowel Disease 2

Anatomical Context for Inflammatory Bowel Disease 2

MalaCards organs/tissues related to Inflammatory Bowel Disease 2:

Publications for Inflammatory Bowel Disease 2

Articles related to Inflammatory Bowel Disease 2:

Genes for Inflammatory Bowel Disease 2

Genes related to Inflammatory Bowel Disease 2 (1 elite genes):

Variations for Inflammatory Bowel Disease 2

Expression for Inflammatory Bowel Disease 2

Pathways for Inflammatory Bowel Disease 2

GO Terms for Inflammatory Bowel Disease 2

Sources for Inflammatory Bowel Disease 2