IBD2
MCID: INF078
MIFTS: 28

Inflammatory Bowel Disease 2 (IBD2)

Categories: Blood diseases, Bone diseases, Gastrointestinal diseases, Genetic diseases, Immune diseases, Rare diseases

Aliases & Classifications for Inflammatory Bowel Disease 2

MalaCards integrated aliases for Inflammatory Bowel Disease 2:

Name: Inflammatory Bowel Disease 2 57 12 13 15 73
Ibd2 57 12

Classifications:



External Ids:

OMIM 57 601458
Disease Ontology 12 DOID:0110900
UMLS 73 C1832321

Summaries for Inflammatory Bowel Disease 2

Disease Ontology : 12 An inflammatory bowel disease that has material basis in variation in the chromosome region 12p13.2-q24.1.

MalaCards based summary : Inflammatory Bowel Disease 2, also known as ibd2, is related to inflammatory bowel disease and crohn's disease. An important gene associated with Inflammatory Bowel Disease 2 is IBD2 (Inflammatory Bowel Disease 2). Affiliated tissues include bone and colon, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Description from OMIM: 601458

Related Diseases for Inflammatory Bowel Disease 2

Diseases in the Inflammatory Bowel Disease family:

Inflammatory Bowel Disease 11 Inflammatory Bowel Disease 1
Inflammatory Bowel Disease 2 Inflammatory Bowel Disease 3
Inflammatory Bowel Disease 7 Inflammatory Bowel Disease 5
Inflammatory Bowel Disease 8 Inflammatory Bowel Disease 6
Inflammatory Bowel Disease 4 Inflammatory Bowel Disease 9
Inflammatory Bowel Disease 10 Inflammatory Bowel Disease 12
Inflammatory Bowel Disease 13 Inflammatory Bowel Disease 14
Inflammatory Bowel Disease 15 Inflammatory Bowel Disease 16
Inflammatory Bowel Disease 17 Inflammatory Bowel Disease 18
Inflammatory Bowel Disease 19 Inflammatory Bowel Disease 20
Inflammatory Bowel Disease 21 Inflammatory Bowel Disease 22
Inflammatory Bowel Disease 23 Inflammatory Bowel Disease 24
Inflammatory Bowel Disease 25, Autosomal Recessive Inflammatory Bowel Disease 26
Inflammatory Bowel Disease 27 Inflammatory Bowel Disease 28, Autosomal Recessive
Inflammatory Bowel Disease 29 Inflammatory Bowel Disease 28
Inflammatory Bowel Disease 25

Diseases related to Inflammatory Bowel Disease 2 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 11)
# Related Disease Score Top Affiliating Genes
1 inflammatory bowel disease 29.4 STAT6 NOD2 IBD2 DLG5
2 crohn's disease 29.2 DLG5 NOD2
3 perrault syndrome 1 11.1
4 ulcerative colitis 10.3
5 colitis 10.3
6 crohn's colitis 10.0
7 inflammatory bowel disease 4 10.0 NOD2 HOGA1
8 inflammatory bowel disease 1 9.9 NOD2 HOGA1
9 inflammatory bowel disease 3 9.9 NOD2 HOGA1
10 inflammatory bowel disease 5 9.8 NOD2 DLG5
11 ileocolitis 9.8 NOD2 DLG5

Graphical network of the top 20 diseases related to Inflammatory Bowel Disease 2:



Diseases related to Inflammatory Bowel Disease 2

Symptoms & Phenotypes for Inflammatory Bowel Disease 2

Clinical features from OMIM:

601458

GenomeRNAi Phenotypes related to Inflammatory Bowel Disease 2 according to GeneCards Suite gene sharing:

26 (show all 22)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-105 10.17 DLG5
2 Increased shRNA abundance (Z-score > 2) GR00366-A-107 10.17 DLG5
3 Increased shRNA abundance (Z-score > 2) GR00366-A-146 10.17 DLG5
4 Increased shRNA abundance (Z-score > 2) GR00366-A-16 10.17 DLG5
5 Increased shRNA abundance (Z-score > 2) GR00366-A-168 10.17 DLG5
6 Increased shRNA abundance (Z-score > 2) GR00366-A-174 10.17 NOD2
7 Increased shRNA abundance (Z-score > 2) GR00366-A-177 10.17 HOXA13 STAT6 NOD2
8 Increased shRNA abundance (Z-score > 2) GR00366-A-178 10.17 HOXA13
9 Increased shRNA abundance (Z-score > 2) GR00366-A-189 10.17 STAT6
10 Increased shRNA abundance (Z-score > 2) GR00366-A-19 10.17 HOXA13 NOD2
11 Increased shRNA abundance (Z-score > 2) GR00366-A-192 10.17 NOD2
12 Increased shRNA abundance (Z-score > 2) GR00366-A-195 10.17 HOXA13 NOD2 DLG5
13 Increased shRNA abundance (Z-score > 2) GR00366-A-201 10.17 STAT6
14 Increased shRNA abundance (Z-score > 2) GR00366-A-210 10.17 HOXA13 NOD2
15 Increased shRNA abundance (Z-score > 2) GR00366-A-214 10.17 DLG5
16 Increased shRNA abundance (Z-score > 2) GR00366-A-30 10.17 DLG5
17 Increased shRNA abundance (Z-score > 2) GR00366-A-36 10.17 NOD2
18 Increased shRNA abundance (Z-score > 2) GR00366-A-39 10.17 HOXA13 STAT6
19 Increased shRNA abundance (Z-score > 2) GR00366-A-43 10.17 STAT6 NOD2
20 Increased shRNA abundance (Z-score > 2) GR00366-A-54 10.17 STAT6
21 Increased shRNA abundance (Z-score > 2) GR00366-A-74 10.17 STAT6
22 Increased shRNA abundance (Z-score > 2) GR00366-A-81 10.17 DLG5

MGI Mouse Phenotypes related to Inflammatory Bowel Disease 2:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 renal/urinary system MP:0005367 8.92 DLG5 HOGA1 HOXA13 STAT6

Drugs & Therapeutics for Inflammatory Bowel Disease 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Anti Tumor Necrosis Factor Alpha Agents and Surgical Stress Response Completed NCT01974869 Anti-tumor necrosis factor alpha agents

Search NIH Clinical Center for Inflammatory Bowel Disease 2

Genetic Tests for Inflammatory Bowel Disease 2

Anatomical Context for Inflammatory Bowel Disease 2

MalaCards organs/tissues related to Inflammatory Bowel Disease 2:

41
Bone, Colon

Publications for Inflammatory Bowel Disease 2

Articles related to Inflammatory Bowel Disease 2:

# Title Authors Year
1
Retrospective evaluation of the clinical utility of serological biomarkers in Chinese patients with inflammatory bowel disease: 2-year clinical experience. ( 27831916 )
2016
2
Phenotype-stratified genetic linkage study demonstrates that IBD2 is an extensive ulcerative colitis locus. ( 16542294 )
2006
3
Absence of an association of the IBD2 locus gene keratin 8 and inflammatory bowel disease in a large genetic association study. ( 15248376 )
2004
4
IBD2 encodes a novel component of the Bub2p-dependent spindle checkpoint in the budding yeast Saccharomyces cerevisiae. ( 12072457 )
2002
5
The IBD2 locus shows linkage heterogeneity between ulcerative colitis and Crohn disease. ( 11078482 )
2000
6
Inflammatory bowel disease. 2: Medical and surgical treatment. ( 10711015 )
1999
7
Identification of multiple candidate genes for IBD susceptibility using high-density transcript mapping in the IBD2 locus on chromosome 12q. ( 10576977 )
1999
8
Inflammatory bowel disease. 2. Current and future therapeutic options. ( 9590988 )
1998
9
Pathogenic factors in inflammatory bowel disease. 2. Crohn's disease. ( 1591873 )
1992
10
Inflammatory bowel disease (2) ( 1886623 )
1991

Variations for Inflammatory Bowel Disease 2

Expression for Inflammatory Bowel Disease 2

Search GEO for disease gene expression data for Inflammatory Bowel Disease 2.

Pathways for Inflammatory Bowel Disease 2

GO Terms for Inflammatory Bowel Disease 2

Sources for Inflammatory Bowel Disease 2

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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