IBD20
MCID: INF079
MIFTS: 24

Inflammatory Bowel Disease 20 (IBD20)

Categories: Blood diseases, Bone diseases, Gastrointestinal diseases, Genetic diseases, Immune diseases, Rare diseases

Aliases & Classifications for Inflammatory Bowel Disease 20

MalaCards integrated aliases for Inflammatory Bowel Disease 20:

Name: Inflammatory Bowel Disease 20 56 12 13 15 71
Ibd20 56 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0110898
OMIM 56 612288
OMIM Phenotypic Series 56 PS266600
UMLS 71 C2676781

Summaries for Inflammatory Bowel Disease 20

Disease Ontology : 12 An inflammatory bowel disease that has material basis in variation in the chromosome region 10q23-q24.

MalaCards based summary : Inflammatory Bowel Disease 20, also known as ibd20, is related to inflammatory bowel disease and ulcerative colitis. An important gene associated with Inflammatory Bowel Disease 20 is IBD20 (Inflammatory Bowel Disease-20), and among its related pathways/superpathways are Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases and Pathogenic Escherichia coli infection. Affiliated tissues include testes and bone.

More information from OMIM: 612288 PS266600

Related Diseases for Inflammatory Bowel Disease 20

Symptoms & Phenotypes for Inflammatory Bowel Disease 20

Clinical features from OMIM:

612288

Drugs & Therapeutics for Inflammatory Bowel Disease 20

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Predicting Relapse of Ulcerative Colitis With Gastrointestinal Ultrasound Recruiting NCT03501758

Search NIH Clinical Center for Inflammatory Bowel Disease 20

Genetic Tests for Inflammatory Bowel Disease 20

Anatomical Context for Inflammatory Bowel Disease 20

MalaCards organs/tissues related to Inflammatory Bowel Disease 20:

40
Testes, Bone

Publications for Inflammatory Bowel Disease 20

Articles related to Inflammatory Bowel Disease 20:

(show all 23)
# Title Authors PMID Year
1
Genome-wide association identifies multiple ulcerative colitis susceptibility loci. 56
20228799 2010
2
Confirmation of multiple Crohn's disease susceptibility loci in a large Dutch-Belgian cohort. 56
19174780 2009
3
Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study. 56
19122664 2009
4
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. 56
18587394 2008
5
Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis. 56
18438405 2008
6
Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease. 56
18438406 2008
7
Gender-stratified analysis of DLG5 R30Q in 4707 patients with Crohn disease and 4973 controls from 12 Caucasian cohorts. 56
17693570 2008
8
Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility. 56
17554261 2007
9
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. 56
17554300 2007
10
Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis. 56
17435756 2007
11
Novel Crohn disease locus identified by genome-wide association maps to a gene desert on 5p13.1 and modulates expression of PTGER4. 56
17447842 2007
12
DLG5 variants contribute to Crohn disease risk in a Canadian population. 56
16450402 2006
13
Evidence of transmission ratio distortion of DLG5 R30Q variant in general and implication of an association with Crohn disease in men. 56
16446977 2006
14
Genetic variation in DLG5 is associated with inflammatory bowel disease. 56
15107852 2004
15
A genomewide analysis provides evidence for novel linkages in inflammatory bowel disease in a large European cohort. 56
10053016 1999
16
Fatigue in a population-based cohort of patients with inflammatory bowel disease 20 years after diagnosis: The IBSEN study. 61
27852169 2017
17
Health-related Quality of Life in Patients with Inflammatory Bowel Disease 20 Years After Diagnosis: Results from the IBSEN Study. 61
27206016 2016
18
Evaluation of early atherosclerosis in patients with inflammatory bowel disease. 61
22466100 2012
19
Pulmonary function tests, high-resolution computed tomography findings and inflammatory bowel disease. 61
17168120 2006
20
Wound infection after elective colorectal resection. 61
15082963 2004
21
Digestive Disease Week 2001. Novel therapeutic principles in inflammatory bowel disease. 20-23 May 2001, Atlanta, GA, USA. 61
15973578 2001
22
[Lipids and total bile acids in the blood of patients with inflammatory bowel diseases]. 61
2218731 1990
23
Random fecal alpha-1-antitrypsin concentration in children with gastrointestinal disease. 61
6970702 1981

Variations for Inflammatory Bowel Disease 20

Expression for Inflammatory Bowel Disease 20

Search GEO for disease gene expression data for Inflammatory Bowel Disease 20.

Pathways for Inflammatory Bowel Disease 20

Pathways related to Inflammatory Bowel Disease 20 according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.88 CLDN4 CLDN2
2 11.56 CLDN4 CLDN2
3 11.38 CLDN4 CLDN2
4 11.12 CLDN4 CLDN2
5
Show member pathways
10.78 CLDN4 CLDN2

GO Terms for Inflammatory Bowel Disease 20

Cellular components related to Inflammatory Bowel Disease 20 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 bicellular tight junction GO:0005923 8.62 CLDN4 CLDN2

Biological processes related to Inflammatory Bowel Disease 20 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules GO:0016338 8.62 CLDN4 CLDN2

Molecular functions related to Inflammatory Bowel Disease 20 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural molecule activity GO:0005198 8.62 CLDN4 CLDN2

Sources for Inflammatory Bowel Disease 20

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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