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IBD20
MCID: INF079
MIFTS: 24

Inflammatory Bowel Disease 20 (IBD20)

Categories: Blood diseases, Bone diseases, Gastrointestinal diseases, Genetic diseases, Immune diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for Inflammatory Bowel Disease 20

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MalaCards integrated aliases for Inflammatory Bowel Disease 20:

Name: Inflammatory Bowel Disease 20 56 12 13 15 71
Ibd20 56 12

Classifications:

MalaCards categories:
Global: Genetic diseases Rare diseases
Anatomical: Gastrointestinal diseases Bone diseases Blood diseases Immune diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:0110898
OMIM 56 612288
OMIM Phenotypic Series 56 PS266600
UMLS 71 C2676781
Sources

Summaries for Inflammatory Bowel Disease 20

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Disease Ontology : 12 An inflammatory bowel disease that has material basis in variation in the chromosome region 10q23-q24.

MalaCards based summary : Inflammatory Bowel Disease 20, also known as ibd20, is related to inflammatory bowel disease and ulcerative colitis. An important gene associated with Inflammatory Bowel Disease 20 is IBD20 (Inflammatory Bowel Disease-20), and among its related pathways/superpathways are Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases and Pathogenic Escherichia coli infection. Affiliated tissues include testes.

More information from OMIM: 612288 PS266600
Sources

Related Diseases for Inflammatory Bowel Disease 20

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Diseases in the Inflammatory Bowel Disease family:

Inflammatory Bowel Disease 11 Inflammatory Bowel Disease 1
Inflammatory Bowel Disease 2 Inflammatory Bowel Disease 3
Inflammatory Bowel Disease 7 Inflammatory Bowel Disease 5
Inflammatory Bowel Disease 8 Inflammatory Bowel Disease 6
Inflammatory Bowel Disease 4 Inflammatory Bowel Disease 9
Inflammatory Bowel Disease 10 Inflammatory Bowel Disease 12
Inflammatory Bowel Disease 13 Inflammatory Bowel Disease 14
Inflammatory Bowel Disease 15 Inflammatory Bowel Disease 16
Inflammatory Bowel Disease 17 Inflammatory Bowel Disease 18
Inflammatory Bowel Disease 19 Inflammatory Bowel Disease 20
Inflammatory Bowel Disease 21 Inflammatory Bowel Disease 22
Inflammatory Bowel Disease 23 Inflammatory Bowel Disease 24
Inflammatory Bowel Disease 25, Autosomal Recessive Inflammatory Bowel Disease 26
Inflammatory Bowel Disease 27 Inflammatory Bowel Disease 28, Autosomal Recessive
Inflammatory Bowel Disease 29 Inflammatory Bowel Disease 28
Inflammatory Bowel Disease 25 Rare Inflammatory Bowel Disease

Diseases related to Inflammatory Bowel Disease 20 via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 inflammatory bowel disease 28.9 PTPN2 IBD20 CLDN2
2 ulcerative colitis 10.0
3 diarrhea 9.4 CLDN4 CLDN2
4 celiac disease 1 9.3 PTPN2 CLDN2

Sources

Symptoms & Phenotypes for Inflammatory Bowel Disease 20

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Clinical features from OMIM:

612288
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Drugs & Therapeutics for Inflammatory Bowel Disease 20

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Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Predicting Relapse of Ulcerative Colitis With Gastrointestinal Ultrasound Recruiting NCT03501758

Search NIH Clinical Center for Inflammatory Bowel Disease 20

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Genetic Tests for Inflammatory Bowel Disease 20

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Anatomical Context for Inflammatory Bowel Disease 20

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MalaCards organs/tissues related to Inflammatory Bowel Disease 20:

40
Testes
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Publications for Inflammatory Bowel Disease 20

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Articles related to Inflammatory Bowel Disease 20:

(show all 25)
# Title Authors PMID Year
1
Genome-wide association identifies multiple ulcerative colitis susceptibility loci. 56
20228799 2010
2
Confirmation of multiple Crohn's disease susceptibility loci in a large Dutch-Belgian cohort. 56
19174780 2009
3
Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study. 56
19122664 2009
4
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. 56
18587394 2008
5
Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis. 56
18438405 2008
6
Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease. 56
18438406 2008
7
Gender-stratified analysis of DLG5 R30Q in 4707 patients with Crohn disease and 4973 controls from 12 Caucasian cohorts. 56
17693570 2008
8
Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility. 56
17554261 2007
9
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. 56
17554300 2007
10
Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis. 56
17435756 2007
11
Novel Crohn disease locus identified by genome-wide association maps to a gene desert on 5p13.1 and modulates expression of PTGER4. 56
17447842 2007
12
Evidence of transmission ratio distortion of DLG5 R30Q variant in general and implication of an association with Crohn disease in men. 56
16446977 2006
13
DLG5 variants contribute to Crohn disease risk in a Canadian population. 56
16450402 2006
14
Genetic variation in DLG5 is associated with inflammatory bowel disease. 56
15107852 2004
15
A genomewide analysis provides evidence for novel linkages in inflammatory bowel disease in a large European cohort. 56
10053016 1999
16
Thiopurine Monotherapy in Paediatric Inflammatory Bowel Disease: 20 Years After Markowitz. 61
32443026 2020
17
Thiopurine Monotherapy in Paediatric Inflammatory Bowel Disease: 20 Years After Markowitz. 61
32142006 2020
18
Fatigue in a population-based cohort of patients with inflammatory bowel disease 20 years after diagnosis: The IBSEN study. 61
27852169 2017
19
Health-related Quality of Life in Patients with Inflammatory Bowel Disease 20 Years After Diagnosis: Results from the IBSEN Study. 61
27206016 2016
20
Evaluation of early atherosclerosis in patients with inflammatory bowel disease. 61
22466100 2012
21
Pulmonary function tests, high-resolution computed tomography findings and inflammatory bowel disease. 61
17168120 2006
22
Wound infection after elective colorectal resection. 61
15082963 2004
23
Digestive Disease Week 2001. Novel therapeutic principles in inflammatory bowel disease. 20-23 May 2001, Atlanta, GA, USA. 61
15973578 2001
24
[Lipids and total bile acids in the blood of patients with inflammatory bowel diseases]. 61
2218731 1990
25
Random fecal alpha-1-antitrypsin concentration in children with gastrointestinal disease. 61
6970702 1981
Sources

Variations for Inflammatory Bowel Disease 20

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Expression for Inflammatory Bowel Disease 20

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Search GEO for disease gene expression data for Inflammatory Bowel Disease 20.
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Pathways for Inflammatory Bowel Disease 20

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Pathways related to Inflammatory Bowel Disease 20 according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases 22
Show member pathways
 11.88 CLDN4 CLDN2
2
Pathogenic Escherichia coli infection 36
11.54 CLDN4 CLDN2
3
Tight junction 36
11.36 CLDN4 CLDN2
4
Cell adhesion molecules (CAMs) 36
11.13 CLDN4 CLDN2
5
Blood-Brain Barrier: Anatomy 64
Show member pathways
 10.78 CLDN4 CLDN2
Sources

GO Terms for Inflammatory Bowel Disease 20

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Cellular components related to Inflammatory Bowel Disease 20 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell-cell junction GO:0005911 8.96 CLDN4 CLDN2
2 bicellular tight junction GO:0005923 8.62 CLDN4 CLDN2

Biological processes related to Inflammatory Bowel Disease 20 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 bicellular tight junction assembly GO:0070830 8.96 CLDN4 CLDN2
2 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules GO:0016338 8.62 CLDN4 CLDN2

Molecular functions related to Inflammatory Bowel Disease 20 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural molecule activity GO:0005198 8.62 CLDN4 CLDN2
Sources

Sources for Inflammatory Bowel Disease 20

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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