IBD4
MCID: INF087
MIFTS: 24

Inflammatory Bowel Disease 4 (IBD4)

Categories: Blood diseases, Bone diseases, Gastrointestinal diseases, Genetic diseases, Immune diseases, Rare diseases

Aliases & Classifications for Inflammatory Bowel Disease 4

MalaCards integrated aliases for Inflammatory Bowel Disease 4:

Name: Inflammatory Bowel Disease 4 57 12 13 15 70
Ibd4 57 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0110903
OMIM® 57 606675
OMIM Phenotypic Series 57 PS266600
UMLS 70 C1847691

Summaries for Inflammatory Bowel Disease 4

Disease Ontology : 12 An inflammatory bowel disease that has material basis in variation in the chromosome region 14q11-q12.

MalaCards based summary : Inflammatory Bowel Disease 4, also known as ibd4, is related to inflammatory bowel disease 2 and inflammatory bowel disease 3. An important gene associated with Inflammatory Bowel Disease 4 is IBD4 (Inflammatory Bowel Disease 4), and among its related pathways/superpathways is Nucleotide-binding Oligomerization Domain (NOD) pathway.

More information from OMIM: 606675 PS266600

Related Diseases for Inflammatory Bowel Disease 4

Diseases in the Inflammatory Bowel Disease family:

Inflammatory Bowel Disease 11 Inflammatory Bowel Disease 1
Inflammatory Bowel Disease 2 Inflammatory Bowel Disease 3
Inflammatory Bowel Disease 7 Inflammatory Bowel Disease 5
Inflammatory Bowel Disease 8 Inflammatory Bowel Disease 6
Inflammatory Bowel Disease 4 Inflammatory Bowel Disease 9
Inflammatory Bowel Disease 10 Inflammatory Bowel Disease 12
Inflammatory Bowel Disease 13 Inflammatory Bowel Disease 14
Inflammatory Bowel Disease 15 Inflammatory Bowel Disease 16
Inflammatory Bowel Disease 17 Inflammatory Bowel Disease 18
Inflammatory Bowel Disease 19 Inflammatory Bowel Disease 20
Inflammatory Bowel Disease 21 Inflammatory Bowel Disease 22
Inflammatory Bowel Disease 23 Inflammatory Bowel Disease 24
Inflammatory Bowel Disease 25, Autosomal Recessive Inflammatory Bowel Disease 26
Inflammatory Bowel Disease 27 Inflammatory Bowel Disease 28, Autosomal Recessive
Inflammatory Bowel Disease 29 Inflammatory Bowel Disease 30
Inflammatory Bowel Disease 28 Inflammatory Bowel Disease 25
Alpi-Related Inflammatory Bowel Disease Trim22-Related Inflammatory Bowel Disease
Rare Inflammatory Bowel Disease

Diseases related to Inflammatory Bowel Disease 4 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 31)
# Related Disease Score Top Affiliating Genes
1 inflammatory bowel disease 2 28.9 PPM1L NPL NOD2 HOGA1
2 inflammatory bowel disease 3 28.4 PPM1L NPL NOD2 HOGA1 CARD6
3 childhood-onset asthma 10.1 RNASE3 EPX
4 loeffler endocarditis 10.1 RNASE3 EPX
5 vernal conjunctivitis 10.1 RNASE3 EPX
6 disseminated eosinophilic collagen disease 10.1 RNASE3 EPX
7 endomyocardial fibrosis 10.1 RNASE3 EPX
8 chronic rhinitis 10.1 RNASE3 EPX
9 urinary schistosomiasis 10.1 RNASE3 EPX
10 inflammatory bowel disease 10.1
11 eosinophilic gastroenteritis 10.1 RNASE3 EPX
12 gastroenteritis 10.1 RNASE3 EPX
13 pollen allergy 10.1 RNASE3 EPX
14 esophagitis, eosinophilic, 1 10.1 RNASE3 EPX
15 proctitis 10.1 RNASE3 EPX
16 onchocerciasis 10.1 RNASE3 EPX
17 pulmonary eosinophilia 10.1 RNASE3 EPX
18 nasal cavity disease 10.0 RNASE3 EPX
19 nose disease 10.0 RNASE3 EPX
20 inflammatory bowel disease 7 10.0 PPM1L NOD2
21 parasitic helminthiasis infectious disease 10.0 RNASE3 EPX
22 food allergy 10.0 RNASE3 EPX
23 bronchial disease 10.0 RNASE3 EPX
24 interstitial nephritis 10.0
25 aspergillosis 9.9 NOD2 EPX
26 collagenous colitis 9.9 RNASE3 NOD2 EPX
27 hypereosinophilic syndrome 9.9 RNASE3 EPX
28 dermatitis, atopic 9.8 RNASE3 NOD2 EPX
29 allergic asthma 9.8 RNASE3 EPX
30 inflammatory bowel disease 6 9.7 PPM1L NOD2 CARD6
31 inflammatory bowel disease 1 9.7 PPM1L NOD2 CARD6

Graphical network of the top 20 diseases related to Inflammatory Bowel Disease 4:



Diseases related to Inflammatory Bowel Disease 4

Symptoms & Phenotypes for Inflammatory Bowel Disease 4

Clinical features from OMIM®:

606675 (Updated 05-Apr-2021)

Drugs & Therapeutics for Inflammatory Bowel Disease 4

Search Clinical Trials , NIH Clinical Center for Inflammatory Bowel Disease 4

Genetic Tests for Inflammatory Bowel Disease 4

Anatomical Context for Inflammatory Bowel Disease 4

Publications for Inflammatory Bowel Disease 4

Articles related to Inflammatory Bowel Disease 4:

(show all 22)
# Title Authors PMID Year
1
High-density genome scan in Crohn disease shows confirmed linkage to chromosome 14q11-12. 61 57
10747815 2000
2
A genome-wide search identifies potential new susceptibility loci for Crohn's disease. 57
10579120 1999
3
Gastrointestinal In Vitro Digests of Infant Biscuits Formulated with Bovine Milk Proteins Positively Affect In Vitro Differentiation of Human Osteoblast-Like Cells. 61
33096628 2020
4
A Promoter Variant Within the Aryl Hydrocarbon Receptor Gene Is Associated with an Epithelial Barrier Defect in Smokers with Crohn's Disease. 61
27598741 2016
5
Colesevelam and colestipol: novel medication resins in the gastrointestinal tract. 61
24921636 2014
6
Eosinophil associated genes in the inflammatory bowel disease 4 region: correlation to inflammatory bowel disease revealed. 61
23197886 2012
7
Laparoscopic major gynecologic surgery in patients with prior laparotomy bowel resection. 61
22643497 2011
8
Effect of 5-aminosalicylates on renal function in patients with inflammatory bowel disease: 4-year follow-up study. 61
18928745 2008
9
4-Hydroxydocosahexaenoic acid, a potent peroxisome proliferator-activated receptor gamma agonist alleviates the symptoms of DSS-induced colitis. 61
18191038 2008
10
The IBD international genetics consortium provides further evidence for linkage to IBD4 and shows gene-environment interaction. 61
15674107 2005
11
Genome wide scan in a Flemish inflammatory bowel disease population: support for the IBD4 locus, population heterogeneity, and epistasis. 61
15194648 2004
12
The interleukin-25 gene located in the inflammatory bowel disease (IBD) 4 region: no association with inflammatory bowel disease. 61
14641539 2003
13
Faecal flora in spondyloarthropathy. 61
9291853 1997
14
Differential excretion of leucocyte granule components in inflammatory bowel disease: implications for pathogenesis. 61
9093012 1997
15
Distribution of varicella zoster virus and herpes simplex virus in disseminated fatal infections. 61
8675738 1996
16
[Social consequences and quality of life in patients with chronic inflammatory bowel disease]. 61
8701273 1996
17
Crypt hyperplasia related to increased lymphocyte activation in the rectal mucosa of children with ulcerative colitis. 61
7801653 1994
18
Systemic diseases associated with intermediate uveitis. 61
8287507 1993
19
[Hartmann's procedure. A retrospective study of 86 cases]. 61
1444149 1992
20
Amebic colitis presenting as acute inflammatory bowel disease. Case report. 61
1683582 1991
21
Increased arachidonic acid levels in phospholipids of human colonic mucosa in inflammatory bowel disease. 61
3665357 1987
22
Anaerobic bacterial populations on normal and diseased human biopsy tissue obtained at colonoscopy. 61
7103479 1982

Variations for Inflammatory Bowel Disease 4

Expression for Inflammatory Bowel Disease 4

Search GEO for disease gene expression data for Inflammatory Bowel Disease 4.

Pathways for Inflammatory Bowel Disease 4

Pathways related to Inflammatory Bowel Disease 4 according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.24 NOD2 CARD6

GO Terms for Inflammatory Bowel Disease 4

Biological processes related to Inflammatory Bowel Disease 4 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 defense response to Gram-positive bacterium GO:0050830 9.16 RNASE3 NOD2
2 defense response to bacterium GO:0042742 9.13 RNASE3 NOD2 EPX
3 innate immune response in mucosa GO:0002227 8.62 RNASE3 NOD2

Molecular functions related to Inflammatory Bowel Disease 4 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 catalytic activity GO:0003824 8.8 PPM1L NPL HOGA1

Sources for Inflammatory Bowel Disease 4

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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