MCID: INF087
MIFTS: 28

Inflammatory Bowel Disease 4

Categories: Gastrointestinal diseases, Genetic diseases, Rare diseases, Bone diseases, Blood diseases, Immune diseases

Aliases & Classifications for Inflammatory Bowel Disease 4

MalaCards integrated aliases for Inflammatory Bowel Disease 4:

Name: Inflammatory Bowel Disease 4 57 12 13 15 73
Ibd4 57 12

Classifications:



External Ids:

OMIM 57 606675
Disease Ontology 12 DOID:0110903
UMLS 73 C1847691

Summaries for Inflammatory Bowel Disease 4

Disease Ontology : 12 An inflammatory bowel disease that has material basis in variation in the chromosome region 14q11-q12.

MalaCards based summary : Inflammatory Bowel Disease 4, also known as ibd4, is related to inflammatory bowel disease and eosinophilic granuloma. An important gene associated with Inflammatory Bowel Disease 4 is IBD4 (Inflammatory Bowel Disease 4), and among its related pathways/superpathways are Allograft rejection and Regulation of IFNA signaling.

Description from OMIM: 606675

Related Diseases for Inflammatory Bowel Disease 4

Diseases in the Inflammatory Bowel Disease family:

Inflammatory Bowel Disease 11 Inflammatory Bowel Disease 1
Inflammatory Bowel Disease 2 Inflammatory Bowel Disease 3
Inflammatory Bowel Disease 7 Inflammatory Bowel Disease 5
Inflammatory Bowel Disease 8 Inflammatory Bowel Disease 6
Inflammatory Bowel Disease 4 Inflammatory Bowel Disease 9
Inflammatory Bowel Disease 10 Inflammatory Bowel Disease 12
Inflammatory Bowel Disease 13 Inflammatory Bowel Disease 14
Inflammatory Bowel Disease 15 Inflammatory Bowel Disease 16
Inflammatory Bowel Disease 17 Inflammatory Bowel Disease 18
Inflammatory Bowel Disease 19 Inflammatory Bowel Disease 20
Inflammatory Bowel Disease 21 Inflammatory Bowel Disease 22
Inflammatory Bowel Disease 23 Inflammatory Bowel Disease 24
Inflammatory Bowel Disease 25, Autosomal Recessive Inflammatory Bowel Disease 26
Inflammatory Bowel Disease 27 Inflammatory Bowel Disease 28, Autosomal Recessive
Inflammatory Bowel Disease 28 Inflammatory Bowel Disease 25

Diseases related to Inflammatory Bowel Disease 4 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 105)
# Related Disease Score Top Affiliating Genes
1 inflammatory bowel disease 26.4 EPX IBD4 IL13 IL4 IL5 NOD2
2 eosinophilic granuloma 10.6 EPX RNASE3
3 conjunctival nevus 10.6 EPX RNASE3
4 collagenous colitis 10.4 EPX RNASE3
5 inflammatory bowel disease 2 10.4 HOGA1 NOD2
6 proctitis 10.4 EPX RNASE3
7 blepharoconjunctivitis 10.4 IL4 RNASE3
8 giant papillary conjunctivitis 10.4 IL4 RNASE3
9 inflammatory bowel disease 1 10.3 HOGA1 NOD2
10 orofacial granulomatosis 10.2 IL4 NOD2
11 ocular cicatricial pemphigoid 10.1 IL4 RNASE3
12 penicillin allergy 10.1 IL13 IL4
13 loeffler endocarditis 10.1 IL5 RNASE3
14 beta-lactam allergy 10.1 IL13 IL4
15 cow milk allergy 10.1 IL5 RNASE3
16 acute graft versus host disease 10.0 IL4 NOD2
17 vernal conjunctivitis 10.0 EPX IL4 RNASE3
18 chronic eosinophilic pneumonia 10.0 IL5 RNASE3
19 status asthmaticus 10.0 IL5 RNASE3
20 cellulitis 10.0 IL5 RNASE3
21 sinusitis 9.9 IL5 RNASE3
22 leprosy 3 9.9 IL4 NOD2
23 inflammatory bowel disease 3 9.9 HOGA1 NOD2 NPL
24 wells syndrome 9.9 IL5 RNASE3
25 egg allergy 9.8 IL4 IL5
26 scleritis 9.8 IL4 IL5
27 churg-strauss syndrome 9.8 IL5 RNASE3
28 mesenteric lymphadenitis 9.8 IL5 NOD2
29 trichinosis 9.8 IL4 IL5
30 non-suppurative otitis media 9.8 IL4 IL5
31 cercarial dermatitis 9.8 IL4 IL5
32 folliculitis 9.8 IL4 IL5
33 toxic oil syndrome 9.8 IL4 IL5
34 cytokine deficiency 9.8 IL13 IL5
35 primary amebic meningoencephalitis 9.8 IL4 IL5
36 angioimmunoblastic lymphadenopathy with dysproteinemia 9.7 IL13 IL5
37 respiratory syncytial virus infectious disease 9.7 IL13 IL5
38 strongyloidiasis 9.7 IL13 IL5
39 ascaris lumbricoides infection 9.7 IL13 IL5
40 eosinophilic gastroenteritis 9.7 EPX IL5 RNASE3
41 esophagitis, eosinophilic, 1 9.6 IL13 IL5
42 night blindness, congenital stationary, type 1a 9.6 IL13 IL5
43 paracoccidioidomycosis 9.6 IL4 IL5
44 esophageal disease 9.5 IL13 IL5
45 cough variant asthma 9.5 IL4 IL5 RNASE3
46 intrinsic asthma 9.5 IL4 IL5 RNASE3
47 atopic keratoconjunctivitis 9.5 IL4 IL5 RNASE3
48 gastrointestinal allergy 9.5 IL4 IL5 RNASE3
49 kimura disease 9.5 IL4 IL5 RNASE3
50 milk allergy 9.5 IL4 IL5 RNASE3

Graphical network of the top 20 diseases related to Inflammatory Bowel Disease 4:



Diseases related to Inflammatory Bowel Disease 4

Symptoms & Phenotypes for Inflammatory Bowel Disease 4

Clinical features from OMIM:

606675

Drugs & Therapeutics for Inflammatory Bowel Disease 4

Search Clinical Trials , NIH Clinical Center for Inflammatory Bowel Disease 4

Genetic Tests for Inflammatory Bowel Disease 4

Anatomical Context for Inflammatory Bowel Disease 4

Publications for Inflammatory Bowel Disease 4

Articles related to Inflammatory Bowel Disease 4:

# Title Authors Year
1
Eosinophil associated genes in the inflammatory bowel disease 4 region: correlation to inflammatory bowel disease revealed. ( 23197886 )
2012

Variations for Inflammatory Bowel Disease 4

Expression for Inflammatory Bowel Disease 4

Search GEO for disease gene expression data for Inflammatory Bowel Disease 4.

Pathways for Inflammatory Bowel Disease 4

Pathways related to Inflammatory Bowel Disease 4 according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.46 EPX IL13 IL4 IL5 RNASE3
2
Show member pathways
12.28 IL13 IL4 IL5
3
Show member pathways
12.24 IL13 IL4 IL5
4
Show member pathways
12.13 IL13 IL4 IL5 NOD2
5
Show member pathways
11.99 IL13 IL4 IL5
6 11.55 IL13 IL4 IL5
7 11.51 IL13 IL4 IL5
8 11.35 IL4 IL5
9 11.34 IL13 IL4 IL5
10 11.21 IL13 IL4
11 11.1 IL13 IL4 IL5
12 11.01 IL4 IL5
13 10.84 IL13 IL4 IL5
14 10.61 IL13 IL4 IL5
15 10.21 IL13 IL4 IL5

GO Terms for Inflammatory Bowel Disease 4

Cellular components related to Inflammatory Bowel Disease 4 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.02 EPX IL13 IL4 IL5 RNASE3

Biological processes related to Inflammatory Bowel Disease 4 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.5 IL13 IL4 IL5
2 defense response to bacterium GO:0042742 9.33 EPX NOD2 RNASE3
3 negative regulation of endothelial cell apoptotic process GO:2000352 9.26 IL13 IL4
4 negative regulation of complement-dependent cytotoxicity GO:1903660 8.96 IL13 IL4
5 positive regulation of B cell proliferation GO:0030890 8.8 IL13 IL4 IL5

Molecular functions related to Inflammatory Bowel Disease 4 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.13 IL13 IL4 IL5
2 cytokine receptor binding GO:0005126 8.62 IL13 IL4

Sources for Inflammatory Bowel Disease 4

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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