IBD4
MCID: INF087
MIFTS: 36

Inflammatory Bowel Disease 4 (IBD4)

Categories: Blood diseases, Bone diseases, Gastrointestinal diseases, Genetic diseases, Immune diseases, Rare diseases

Aliases & Classifications for Inflammatory Bowel Disease 4

MalaCards integrated aliases for Inflammatory Bowel Disease 4:

Name: Inflammatory Bowel Disease 4 57 12 13 15 73
Ibd4 57 12

Classifications:



External Ids:

OMIM 57 606675
Disease Ontology 12 DOID:0110903
UMLS 73 C1847691

Summaries for Inflammatory Bowel Disease 4

Disease Ontology : 12 An inflammatory bowel disease that has material basis in variation in the chromosome region 14q11-q12.

MalaCards based summary : Inflammatory Bowel Disease 4, also known as ibd4, is related to inflammatory bowel disease and perrault syndrome 1. An important gene associated with Inflammatory Bowel Disease 4 is IBD4 (Inflammatory Bowel Disease 4), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. Affiliated tissues include bone, lung and skin, and related phenotypes are digestive/alimentary and immune system

Description from OMIM: 606675

Related Diseases for Inflammatory Bowel Disease 4

Diseases in the Inflammatory Bowel Disease family:

Inflammatory Bowel Disease 11 Inflammatory Bowel Disease 1
Inflammatory Bowel Disease 2 Inflammatory Bowel Disease 3
Inflammatory Bowel Disease 7 Inflammatory Bowel Disease 5
Inflammatory Bowel Disease 8 Inflammatory Bowel Disease 6
Inflammatory Bowel Disease 4 Inflammatory Bowel Disease 9
Inflammatory Bowel Disease 10 Inflammatory Bowel Disease 12
Inflammatory Bowel Disease 13 Inflammatory Bowel Disease 14
Inflammatory Bowel Disease 15 Inflammatory Bowel Disease 16
Inflammatory Bowel Disease 17 Inflammatory Bowel Disease 18
Inflammatory Bowel Disease 19 Inflammatory Bowel Disease 20
Inflammatory Bowel Disease 21 Inflammatory Bowel Disease 22
Inflammatory Bowel Disease 23 Inflammatory Bowel Disease 24
Inflammatory Bowel Disease 25, Autosomal Recessive Inflammatory Bowel Disease 26
Inflammatory Bowel Disease 27 Inflammatory Bowel Disease 28, Autosomal Recessive
Inflammatory Bowel Disease 29 Inflammatory Bowel Disease 28
Inflammatory Bowel Disease 25

Diseases related to Inflammatory Bowel Disease 4 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 107)
# Related Disease Score Top Affiliating Genes
1 inflammatory bowel disease 28.8 EPX IBD4 IL13 IL4 IL5 NOD2
2 perrault syndrome 1 11.1
3 eosinophilic granuloma 10.2 EPX RNASE3
4 conjunctival nevus 10.2 EPX RNASE3
5 collagenous colitis 10.2 EPX RNASE3
6 proctitis 10.1 EPX RNASE3
7 blepharoconjunctivitis 10.1 IL4 RNASE3
8 inflammatory bowel disease 2 10.1 HOGA1 NOD2
9 giant papillary conjunctivitis 10.1 IL4 RNASE3
10 inflammatory bowel disease 1 10.1 HOGA1 NOD2
11 trichuriasis 10.1 IL13 RNASE3
12 orofacial granulomatosis 10.0 IL4 NOD2
13 ocular cicatricial pemphigoid 10.0 IL4 RNASE3
14 loeffler endocarditis 10.0 IL5 RNASE3
15 penicillin allergy 10.0 IL13 IL4
16 cow milk allergy 10.0 IL5 RNASE3
17 vernal conjunctivitis 10.0 EPX IL4 RNASE3
18 beta-lactam allergy 10.0 IL13 IL4
19 status asthmaticus 10.0 IL5 RNASE3
20 hypereosinophilic syndrome, idiopathic 10.0 IL5 KIT
21 chronic eosinophilic pneumonia 10.0 IL5 RNASE3
22 sinusitis 10.0 IL5 RNASE3
23 mycoplasma pneumoniae pneumonia 10.0 IL13 IL4
24 q fever 10.0 IL4 NOD2
25 wells syndrome 10.0 IL5 RNASE3
26 inflammatory bowel disease 3 10.0 HOGA1 NOD2 NPL
27 scleritis 9.9 IL4 IL5
28 egg allergy 9.9 IL4 IL5
29 sulfamethoxazole allergy 9.9 IL4 IL5
30 churg-strauss syndrome 9.9 IL5 RNASE3
31 gaucher disease, type ii 9.9 IL4 IL5
32 trichinosis 9.9 IL4 IL5
33 mesenteric lymphadenitis 9.9 IL5 NOD2
34 non-suppurative otitis media 9.9 IL4 IL5
35 filarial elephantiasis 9.9 IL4 IL5
36 acute graft versus host disease 9.9 IL4 NOD2
37 cytokine deficiency 9.9 IL13 IL5
38 toxic oil syndrome 9.9 IL4 IL5
39 eosinophilic gastroenteritis 9.9 EPX IL5 RNASE3
40 angioimmunoblastic lymphadenopathy with dysproteinemia 9.9 IL13 IL5
41 respiratory syncytial virus infectious disease 9.9 IL13 IL5
42 folliculitis 9.9 IL4 IL5
43 strongyloidiasis 9.9 IL13 IL5
44 ascaris lumbricoides infection 9.9 IL13 IL5
45 cellulitis 9.9 IL5 RNASE3
46 cough variant asthma 9.9 IL4 IL5 RNASE3
47 atopic keratoconjunctivitis 9.9 IL4 IL5 RNASE3
48 esophagitis, eosinophilic, 1 9.9 IL13 IL5
49 intrinsic asthma 9.9 IL4 IL5 RNASE3
50 gastroenteritis 9.9 IL4 IL5 RNASE3

Graphical network of the top 20 diseases related to Inflammatory Bowel Disease 4:



Diseases related to Inflammatory Bowel Disease 4

Symptoms & Phenotypes for Inflammatory Bowel Disease 4

Clinical features from OMIM:

606675

MGI Mouse Phenotypes related to Inflammatory Bowel Disease 4:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.35 IL13 IL4 IL5 KIT NOD2
2 immune system MP:0005387 9.17 EPX IL13 IL4 IL5 KIT NOD2

Drugs & Therapeutics for Inflammatory Bowel Disease 4

Search Clinical Trials , NIH Clinical Center for Inflammatory Bowel Disease 4

Genetic Tests for Inflammatory Bowel Disease 4

Anatomical Context for Inflammatory Bowel Disease 4

MalaCards organs/tissues related to Inflammatory Bowel Disease 4:

41
Bone, Lung, Skin

Publications for Inflammatory Bowel Disease 4

Articles related to Inflammatory Bowel Disease 4:

# Title Authors Year
1
Eosinophil associated genes in the inflammatory bowel disease 4 region: correlation to inflammatory bowel disease revealed. ( 23197886 )
2012
2
Effect of 5-aminosalicylates on renal function in patients with inflammatory bowel disease: 4-year follow-up study. ( 18928745 )
2008
3
The IBD international genetics consortium provides further evidence for linkage to IBD4 and shows gene-environment interaction. ( 15674107 )
2005
4
Genome wide scan in a Flemish inflammatory bowel disease population: support for the IBD4 locus, population heterogeneity, and epistasis. ( 15194648 )
2004

Variations for Inflammatory Bowel Disease 4

Expression for Inflammatory Bowel Disease 4

Search GEO for disease gene expression data for Inflammatory Bowel Disease 4.

Pathways for Inflammatory Bowel Disease 4

Pathways related to Inflammatory Bowel Disease 4 according to GeneCards Suite gene sharing:

(show all 21)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.72 EPX IL13 IL4 IL5 KIT NOD2
2
Show member pathways
13.07 IL13 IL4 IL5 KIT NOD2
3 12.55 IL13 IL4 IL5 KIT
4
Show member pathways
12.54 EPX IL13 IL4 IL5 RNASE3
5
Show member pathways
12.33 IL13 IL4 IL5 NOD2
6
Show member pathways
12.14 IL13 IL4 IL5
7
Show member pathways
12.08 IL13 IL4 IL5
8
Show member pathways
11.97 IL13 IL4 IL5 KIT
9 11.75 IL4 IL5 KIT
10 11.64 IL4 IL5 KIT
11 11.52 IL13 IL4 IL5
12 11.34 IL13 IL4 IL5
13 11.28 IL13 IL4
14 11.16 IL13 IL4 IL5
15 11.09 IL4 IL5
16 10.95 IL13 IL4 IL5
17 10.94 IL13 IL4 IL5
18 10.83 IL13 IL4 IL5 KIT
19 10.79 IL13 IL4 IL5
20 10.74 IL13 IL4 IL5 KIT
21 10.55 IL13 IL4 IL5

GO Terms for Inflammatory Bowel Disease 4

Cellular components related to Inflammatory Bowel Disease 4 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.1 EPX IL13 IL4 IL5 KIT RNASE3

Biological processes related to Inflammatory Bowel Disease 4 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 defense response to bacterium GO:0042742 9.61 EPX NOD2 RNASE3
2 cytokine-mediated signaling pathway GO:0019221 9.56 IL13 IL4 IL5 KIT
3 positive regulation of Notch signaling pathway GO:0045747 9.46 KIT NOD2
4 negative regulation of endothelial cell apoptotic process GO:2000352 9.4 IL13 IL4
5 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.37 KIT NOD2
6 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.33 IL13 IL4 KIT
7 positive regulation of JAK-STAT cascade GO:0046427 9.32 IL5 KIT
8 negative regulation of complement-dependent cytotoxicity GO:1903660 8.96 IL13 IL4
9 positive regulation of B cell proliferation GO:0030890 8.8 IL13 IL4 IL5

Molecular functions related to Inflammatory Bowel Disease 4 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.13 IL13 IL4 IL5
2 cytokine receptor binding GO:0005126 8.62 IL13 IL4

Sources for Inflammatory Bowel Disease 4

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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