IBD5
MCID: INF088
MIFTS: 25

Inflammatory Bowel Disease 5 (IBD5)

Categories: Blood diseases, Bone diseases, Gastrointestinal diseases, Genetic diseases, Immune diseases, Rare diseases

Aliases & Classifications for Inflammatory Bowel Disease 5

MalaCards integrated aliases for Inflammatory Bowel Disease 5:

Name: Inflammatory Bowel Disease 5 58 12 13 6 15 74
Ibd5 58 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0110889
OMIM 58 606348
UMLS 74 C1853438

Summaries for Inflammatory Bowel Disease 5

Disease Ontology : 12 An inflammatory bowel disease that has material basis in variation in the chromosome region 5q31.

MalaCards based summary : Inflammatory Bowel Disease 5, also known as ibd5, is related to ulcerative colitis and colitis. An important gene associated with Inflammatory Bowel Disease 5 is IBD5 (Inflammatory Bowel Disease 5). Related phenotype is digestive/alimentary.

Description from OMIM: 606348

Related Diseases for Inflammatory Bowel Disease 5

Diseases in the Inflammatory Bowel Disease family:

Inflammatory Bowel Disease 11 Inflammatory Bowel Disease 1
Inflammatory Bowel Disease 2 Inflammatory Bowel Disease 3
Inflammatory Bowel Disease 7 Inflammatory Bowel Disease 5
Inflammatory Bowel Disease 8 Inflammatory Bowel Disease 6
Inflammatory Bowel Disease 4 Inflammatory Bowel Disease 9
Inflammatory Bowel Disease 10 Inflammatory Bowel Disease 12
Inflammatory Bowel Disease 13 Inflammatory Bowel Disease 14
Inflammatory Bowel Disease 15 Inflammatory Bowel Disease 16
Inflammatory Bowel Disease 17 Inflammatory Bowel Disease 18
Inflammatory Bowel Disease 19 Inflammatory Bowel Disease 20
Inflammatory Bowel Disease 21 Inflammatory Bowel Disease 22
Inflammatory Bowel Disease 23 Inflammatory Bowel Disease 24
Inflammatory Bowel Disease 25, Autosomal Recessive Inflammatory Bowel Disease 26
Inflammatory Bowel Disease 27 Inflammatory Bowel Disease 28, Autosomal Recessive
Inflammatory Bowel Disease 29 Inflammatory Bowel Disease 28
Inflammatory Bowel Disease 25

Diseases related to Inflammatory Bowel Disease 5 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 12)
# Related Disease Score Top Affiliating Genes
1 ulcerative colitis 29.5 ATG16L1 IL23R NOD2
2 colitis 29.5 ATG16L1 IL23R NOD2
3 crohn's disease 29.2 ATG16L1 DLG5 IL23R NOD2 SLC22A4 SLC22A5
4 inflammatory bowel disease 29.1 ATG16L1 IL23R NOD2
5 perrault syndrome 1 11.1
6 crohn's colitis 10.0
7 inflammatory bowel disease 2 10.0 DLG5 NOD2
8 ileocolitis 9.9 DLG5 NOD2
9 inflammatory bowel disease 1 9.8 NOD2 SLC22A4 SLC22A5
10 spondylitis 9.8 IL23R NOD2
11 psoriatic arthritis 9.7 IL23R NOD2
12 intestinal disease 9.5 ATG16L1 IL23R NOD2

Graphical network of the top 20 diseases related to Inflammatory Bowel Disease 5:



Diseases related to Inflammatory Bowel Disease 5

Symptoms & Phenotypes for Inflammatory Bowel Disease 5

Clinical features from OMIM:

606348

MGI Mouse Phenotypes related to Inflammatory Bowel Disease 5:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 8.92 ATG16L1 IL23R NOD2 SLC22A4

Drugs & Therapeutics for Inflammatory Bowel Disease 5

Search Clinical Trials , NIH Clinical Center for Inflammatory Bowel Disease 5

Genetic Tests for Inflammatory Bowel Disease 5

Anatomical Context for Inflammatory Bowel Disease 5

Publications for Inflammatory Bowel Disease 5

Articles related to Inflammatory Bowel Disease 5:

# Title Authors Year
1
Course of disease, drug treatment and health-related quality of life in patients with inflammatory bowel disease 5 years after initial diagnosis. ( 16148548 )
2005
2
IBD5 is a general risk factor for inflammatory bowel disease: replication of association with Crohn disease and identification of a novel association with ulcerative colitis. ( 12776251 )
2003
3
Further evidence of IBD5/CARD15 (NOD2) epistasis in the susceptibility to ulcerative colitis. ( 14655097 )
2003
4
IBD5: the second Crohn's disease gene? ( 12479655 )
2002

Variations for Inflammatory Bowel Disease 5

ClinVar genetic disease variations for Inflammatory Bowel Disease 5:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 SLC22A5 SLC22A5, -207G-C single nucleotide variant Uncertain significance

Expression for Inflammatory Bowel Disease 5

Search GEO for disease gene expression data for Inflammatory Bowel Disease 5.

Pathways for Inflammatory Bowel Disease 5

GO Terms for Inflammatory Bowel Disease 5

Biological processes related to Inflammatory Bowel Disease 5 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.54 ICOSLG IL23R NOD2
2 positive regulation of activated T cell proliferation GO:0042104 9.32 ICOSLG IL23R
3 positive regulation of interleukin-17 production GO:0032740 9.26 IL23R NOD2
4 carnitine transport GO:0015879 9.16 SLC22A4 SLC22A5
5 quaternary ammonium group transport GO:0015697 8.96 SLC22A4 SLC22A5
6 carnitine transmembrane transport GO:1902603 8.62 SLC22A4 SLC22A5

Molecular functions related to Inflammatory Bowel Disease 5 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 symporter activity GO:0015293 9.32 SLC22A4 SLC22A5
2 PDZ domain binding GO:0030165 9.26 SLC22A4 SLC22A5
3 transporter activity GO:0005215 9.16 SLC22A4 SLC22A5
4 quaternary ammonium group transmembrane transporter activity GO:0015651 8.96 SLC22A4 SLC22A5
5 carnitine transmembrane transporter activity GO:0015226 8.62 SLC22A4 SLC22A5

Sources for Inflammatory Bowel Disease 5

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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