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IBD6
MCID: INF089
MIFTS: 28

Inflammatory Bowel Disease 6 (IBD6)

Categories: Blood diseases, Bone diseases, Gastrointestinal diseases, Genetic diseases, Immune diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for Inflammatory Bowel Disease 6

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MalaCards integrated aliases for Inflammatory Bowel Disease 6:

Name: Inflammatory Bowel Disease 6 57 12 13 15 71
Ibd6 57 12

Classifications:

MalaCards categories:
Global: Genetic diseases Rare diseases
Anatomical: Gastrointestinal diseases Bone diseases Blood diseases Immune diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:0110907
OMIM® 57 606674
OMIM Phenotypic Series 57 PS266600
UMLS 71 C1847692
Sources

Summaries for Inflammatory Bowel Disease 6

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Disease Ontology : 12 An inflammatory bowel disease that has material basis in variation in the chromosome region 19p13.

MalaCards based summary : Inflammatory Bowel Disease 6, also known as ibd6, is related to inflammatory bowel disease and inflammatory bowel disease 2. An important gene associated with Inflammatory Bowel Disease 6 is IBD6 (Inflammatory Bowel Disease 6), and among its related pathways/superpathways are NOD-like receptor signaling pathway and Nucleotide-binding Oligomerization Domain (NOD) pathway. Affiliated tissues include prostate.

More information from OMIM: 606674 PS266600
Sources

Related Diseases for Inflammatory Bowel Disease 6

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Diseases in the Inflammatory Bowel Disease family:

Inflammatory Bowel Disease 11 Inflammatory Bowel Disease 1
Inflammatory Bowel Disease 2 Inflammatory Bowel Disease 3
Inflammatory Bowel Disease 7 Inflammatory Bowel Disease 5
Inflammatory Bowel Disease 8 Inflammatory Bowel Disease 6
Inflammatory Bowel Disease 4 Inflammatory Bowel Disease 9
Inflammatory Bowel Disease 10 Inflammatory Bowel Disease 12
Inflammatory Bowel Disease 13 Inflammatory Bowel Disease 14
Inflammatory Bowel Disease 15 Inflammatory Bowel Disease 16
Inflammatory Bowel Disease 17 Inflammatory Bowel Disease 18
Inflammatory Bowel Disease 19 Inflammatory Bowel Disease 20
Inflammatory Bowel Disease 21 Inflammatory Bowel Disease 22
Inflammatory Bowel Disease 23 Inflammatory Bowel Disease 24
Inflammatory Bowel Disease 25, Autosomal Recessive Inflammatory Bowel Disease 26
Inflammatory Bowel Disease 27 Inflammatory Bowel Disease 28, Autosomal Recessive
Inflammatory Bowel Disease 29 Inflammatory Bowel Disease 30
Inflammatory Bowel Disease 28 Inflammatory Bowel Disease 25
Rare Inflammatory Bowel Disease

Diseases related to Inflammatory Bowel Disease 6 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 19)
# Related Disease Score Top Affiliating Genes
1 inflammatory bowel disease 31.4 NOD2 MYO9B IL23R IBD6 ATG16L1
2 inflammatory bowel disease 2 30.0 PPM1L NOD2
3 inflammatory bowel disease 5 29.8 NOD2 MYO9B IL23R ATG16L1
4 celiac disease 1 29.7 NOD2 MYO9B IL23R ATG16L1
5 crohn's disease 29.6 NOD2 IL23R ATG16L1
6 inflammatory bowel disease 1 29.0 PPM1L NOD2 IL23R CARD6 ATG16L1 ADGRE3
7 uveoparotid fever 10.2 NOD2 ATG16L1
8 ileocolitis 10.2 NOD2 ATG16L1
9 inflammatory bowel disease 7 10.1 PPM1L NOD2
10 mega-corpus-callosum syndrome with cerebellar hypoplasia and cortical malformations 10.1 MAST3 MAST2
11 anorectal stricture 10.1 NOD2 ATG16L1
12 inflammatory bowel disease 18 10.1 NOD2 ATG16L1
13 crohn's colitis 10.1 NOD2 ATG16L1
14 autoimmune disease of gastrointestinal tract 10.0 NOD2 IL23R ATG16L1
15 ulcerative colitis 9.9 NOD2 MYO9B IL23R ATG16L1
16 colitis 9.9 NOD2 MYO9B IL23R ATG16L1
17 inflammatory bowel disease 4 9.9 PPM1L NOD2 CARD6
18 panuveitis 9.9 NOD2 IL23R
19 inflammatory bowel disease 3 9.6 PPM1L NOD2 IL23R CARD6 ADGRE3

Graphical network of the top 20 diseases related to Inflammatory Bowel Disease 6:



Diseases related to Inflammatory Bowel Disease 6
Sources

Symptoms & Phenotypes for Inflammatory Bowel Disease 6

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Clinical features from OMIM®:

606674 (Updated 05-Mar-2021)

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Drugs & Therapeutics for Inflammatory Bowel Disease 6

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Search Clinical Trials , NIH Clinical Center for Inflammatory Bowel Disease 6

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Genetic Tests for Inflammatory Bowel Disease 6

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Anatomical Context for Inflammatory Bowel Disease 6

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MalaCards organs/tissues related to Inflammatory Bowel Disease 6:

40
Prostate
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Publications for Inflammatory Bowel Disease 6

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Articles related to Inflammatory Bowel Disease 6:

(show all 26)
# Title Authors PMID Year
1
The IBD6 Crohn's disease locus demonstrates complex interactions with CARD15 and IBD5 disease-associated variants. 57 61
12928481 2003
2
Genomewide search in Canadian families with inflammatory bowel disease reveals two novel susceptibility loci. 57
10777714 2000
3
Acceptance of disease and the quality of life in patients with enteric stoma. 61
29513247 2018
4
ACR Appropriateness Criteria for external beam radiation therapy treatment planning for clinically localized prostate cancer, part II of II. 61
29114613 2017
5
Home Nasogastric Feeds: Feeding Status and Growth Outcomes in a Pediatric Population. 61
25261413 2016
6
Thiopurine metabolites variations during co-treatment with aminosalicylates for inflammatory bowel disease: effect of N-acetyl transferase polymorphisms. 61
25834322 2015
7
Model-Based Individualized Treatment of Chemotherapeutics: Bayesian Population Modeling and Dose Optimization. 61
26226448 2015
8
A randomized controlled trial assessing the effect of prescribed patient position changes during colonoscope withdrawal on adenoma detection. 61
24629419 2014
9
Transanal endoscopic microsurgery approach for rectal stump resection as an alternative to transperitoneal stump resection. 61
23188592 2013
10
Fecal microbiota transplantation: techniques, applications, and issues. 61
23101687 2012
11
Single nucleotide polymorphisms in C-type lectin genes, clustered in the IBD2 and IBD6 susceptibility loci, may play a role in the pathogenesis of inflammatory bowel diseases. 61
22664939 2012
12
Cerebral venous thrombosis in inflammatory bowel diseases: eight cases and literature review. 61
22017824 2011
13
Hepatosplenic T-cell lymphoma and inflammatory bowel disease. 61
21122554 2010
14
Characteristics and predictors of recurrence of anterior and intermediate uveitis in a Canadian referral centre. 61
20379299 2010
15
6-Thioguanine therapy in Crohn's disease--observational data in Swedish patients. 61
18799369 2009
16
MAST3: a novel IBD risk factor that modulates TLR4 signaling. 61
18650832 2008
17
An SNP linkage scan identifies significant Crohn's disease loci on chromosomes 13q13.3 and, in Jewish families, on 1p35.2 and 3q29. 61
18246054 2008
18
Hepatosplenic T cell lymphoma associated with infliximab use in young patients treated for inflammatory bowel disease. 61
17255842 2007
19
A functional candidate screen for coeliac disease genes. 61
16835590 2006
20
Haplotype-based association analysis of 56 functional candidate genes in the IBD6 locus on chromosome 19. 61
16570073 2006
21
Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations. 61
15788214 2005
22
Characterization of genotype-phenotype relationships and stratification by the CARD15 variant genotype for inflammatory bowel disease susceptibility loci using multiple short tandem repeat genetic markers. 61
15643611 2005
23
Inflammatory bowel disease is linked to 19p13 and associated with ICAM-1. 61
15290909 2004
24
Genetics of inflammatory bowel disease. 61
9682668 1998
25
Vesico-colic fistulae in the Grampian region: presentation, assessment, management and outcome. 61
9195812 1997
26
Serum lysozyme in Crohn's disease and ulcerative colitis. 61
609977 1977
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Variations for Inflammatory Bowel Disease 6

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Expression for Inflammatory Bowel Disease 6

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Search GEO for disease gene expression data for Inflammatory Bowel Disease 6.
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Pathways for Inflammatory Bowel Disease 6

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Pathways related to Inflammatory Bowel Disease 6 according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
NOD-like receptor signaling pathway 36
11.59 NOD2 CARD6 ATG16L1
2
Nucleotide-binding Oligomerization Domain (NOD) pathway 1
10.87 NOD2 CARD6
3
Linoleic acid metabolism 36
Show member pathways
 10.86 PLA2G2E CYP4F3 CYP4F2
4
HETE and HPETE biosynthesis and metabolism 23
Show member pathways
 10.39 CYP4F3 CYP4F2
Sources

GO Terms for Inflammatory Bowel Disease 6

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Biological processes related to Inflammatory Bowel Disease 6 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intracellular signal transduction GO:0035556 9.73 NOD2 MYO9B MAST3 MAST2
2 positive regulation of interleukin-12 production GO:0032735 9.48 NOD2 IL23R
3 arachidonic acid metabolic process GO:0019369 9.46 CYP4F3 CYP4F2
4 leukotriene metabolic process GO:0006691 9.4 CYP4F3 CYP4F2
5 positive regulation of interleukin-17 production GO:0032740 9.37 NOD2 IL23R
6 icosanoid metabolic process GO:0006690 9.32 CYP4F3 CYP4F2
7 phylloquinone catabolic process GO:0042376 9.26 CYP4F3 CYP4F2
8 leukotriene B4 catabolic process GO:0036101 9.16 CYP4F3 CYP4F2
9 vitamin K catabolic process GO:0042377 8.96 CYP4F3 CYP4F2
10 menaquinone catabolic process GO:0042361 8.62 CYP4F3 CYP4F2

Molecular functions related to Inflammatory Bowel Disease 6 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 aromatase activity GO:0070330 9.16 CYP4F3 CYP4F2
2 arachidonic acid monooxygenase activity GO:0008391 8.96 CYP4F3 CYP4F2
3 leukotriene-B4 20-monooxygenase activity GO:0050051 8.62 CYP4F3 CYP4F2
Sources

Sources for Inflammatory Bowel Disease 6

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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