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IBD6
MCID: INF089
MIFTS: 35

Inflammatory Bowel Disease 6 (IBD6)

Categories: Blood diseases, Bone diseases, Gastrointestinal diseases, Genetic diseases, Immune diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Inflammatory Bowel Disease 6

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MalaCards integrated aliases for Inflammatory Bowel Disease 6:

Name: Inflammatory Bowel Disease 6 57 12 13 15 72
Ibd6 57 12

Classifications:

MalaCards categories:
Global: Genetic diseases Rare diseases
Anatomical: Gastrointestinal diseases Bone diseases Blood diseases Immune diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:0110907
UMLS 72 C1847692
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Summaries for Inflammatory Bowel Disease 6

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Disease Ontology : 12 An inflammatory bowel disease that has material basis in variation in the chromosome region 19p13.

MalaCards based summary : Inflammatory Bowel Disease 6, also known as ibd6, is related to colitis and ileocolitis. An important gene associated with Inflammatory Bowel Disease 6 is IBD6 (Inflammatory Bowel Disease 6), and among its related pathways/superpathways are Innate Immune System and Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. The drugs tannic acid and Tocopherol have been mentioned in the context of this disorder. Affiliated tissues include bone, t cells and prostate.

More information from OMIM: 606674 PS266600
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Related Diseases for Inflammatory Bowel Disease 6

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Diseases in the Inflammatory Bowel Disease family:

Inflammatory Bowel Disease 11 Inflammatory Bowel Disease 1
Inflammatory Bowel Disease 2 Inflammatory Bowel Disease 3
Inflammatory Bowel Disease 7 Inflammatory Bowel Disease 5
Inflammatory Bowel Disease 8 Inflammatory Bowel Disease 6
Inflammatory Bowel Disease 4 Inflammatory Bowel Disease 9
Inflammatory Bowel Disease 10 Inflammatory Bowel Disease 12
Inflammatory Bowel Disease 13 Inflammatory Bowel Disease 14
Inflammatory Bowel Disease 15 Inflammatory Bowel Disease 16
Inflammatory Bowel Disease 17 Inflammatory Bowel Disease 18
Inflammatory Bowel Disease 19 Inflammatory Bowel Disease 20
Inflammatory Bowel Disease 21 Inflammatory Bowel Disease 22
Inflammatory Bowel Disease 23 Inflammatory Bowel Disease 24
Inflammatory Bowel Disease 25, Autosomal Recessive Inflammatory Bowel Disease 26
Inflammatory Bowel Disease 27 Inflammatory Bowel Disease 28, Autosomal Recessive
Inflammatory Bowel Disease 29 Inflammatory Bowel Disease 28
Inflammatory Bowel Disease 25 Rare Inflammatory Bowel Disease

Diseases related to Inflammatory Bowel Disease 6 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 18)
# Related Disease Score Top Affiliating Genes
1 colitis 30.0 TLR4 NOD2 MYO9B
2 ileocolitis 10.5 NOD2 MYO9B
3 pouchitis 10.4 TLR4 NOD2
4 celiac disease 1 10.2
5 inflammatory bowel disease 1 10.2
6 inflammatory bowel disease 2 10.2
7 inflammatory bowel disease 5 10.2
8 crohn's disease 10.2
9 fungal keratitis 10.0 TLR4 CD209
10 inflammatory bowel disease 10.0
11 chronic conjunctivitis 10.0 ICAM1 FCER2
12 ulcerative colitis 10.0 TLR4 NOD2 MYO9B
13 spondylarthropathy 9.9 TLR4 NOD2
14 ischemic colitis 9.9
15 dysentery 9.9
16 diarrhea 9.9
17 mycobacterium tuberculosis 1 9.8 TLR4 IL12RB1 CD209
18 lymphadenitis 9.3 TLR4 NOD2 IL12RB1 ICAM1 CD209

Graphical network of the top 20 diseases related to Inflammatory Bowel Disease 6:



Diseases related to Inflammatory Bowel Disease 6
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Symptoms & Phenotypes for Inflammatory Bowel Disease 6

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Clinical features from OMIM:

606674
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Drugs & Therapeutics for Inflammatory Bowel Disease 6

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Drugs for Inflammatory Bowel Disease 6 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
tannic acid Approved Phase 4 1401-55-4
2
Tocopherol Approved, Investigational Phase 4 1406-66-2, 54-28-4 14986
3
Benzocaine Approved, Investigational Phase 4 94-09-7, 1994-09-7 2337
4
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4 59-02-9 14985
5
Vitamin D3 Approved, Nutraceutical Phase 4 67-97-0 6221 5280795
6
Ergocalciferol Approved, Nutraceutical Phase 4 50-14-6 5280793
7
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4 1406-16-2
8
Calcium Approved, Nutraceutical Phase 4 7440-70-2 271
9 Tocotrienol Investigational Phase 4 6829-55-6
10 Micronutrients Phase 4
11 Trace Elements Phase 4
12 Hormones Phase 4
13 Vitamins Phase 4
14 Tocotrienols Phase 4
15 Tocopherols Phase 4
16 Nutrients Phase 4
17 Vitamin D2 Phase 4
18 Ergocalciferols Phase 4
19 Calcium, Dietary Phase 4
20 Calciferol Phase 4
21 Bone Density Conservation Agents Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Maintenance of Vitamin D Sufficiency With Oral Vitamin D Supplementation in Malaysian Women of Malay and Indian Ethnicity With Post Menopausal Osteoporosis Unknown status NCT02389179 Phase 4 Vitamin D3

Search NIH Clinical Center for Inflammatory Bowel Disease 6

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Genetic Tests for Inflammatory Bowel Disease 6

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Anatomical Context for Inflammatory Bowel Disease 6

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MalaCards organs/tissues related to Inflammatory Bowel Disease 6:

41
Bone, T Cells, Prostate
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Publications for Inflammatory Bowel Disease 6

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Articles related to Inflammatory Bowel Disease 6:

(show all 27)
# Title Authors PMID Year
1
The IBD6 Crohn's disease locus demonstrates complex interactions with CARD15 and IBD5 disease-associated variants. 38 8
12928481 2003
2
Genomewide search in Canadian families with inflammatory bowel disease reveals two novel susceptibility loci. 8
10777714 2000
3
Endoscopic Resections in Inflammatory Bowel Disease: A Multicentre European Outcomes Study. 38
30994915 2019
4
Acceptance of disease and the quality of life in patients with enteric stoma. 38
29513247 2018
5
ACR Appropriateness Criteria for external beam radiation therapy treatment planning for clinically localized prostate cancer, part II of II. 38
29114613 2017
6
Home Nasogastric Feeds: Feeding Status and Growth Outcomes in a Pediatric Population. 38
25261413 2016
7
Thiopurine metabolites variations during co-treatment with aminosalicylates for inflammatory bowel disease: effect of N-acetyl transferase polymorphisms. 38
25834322 2015
8
Model-Based Individualized Treatment of Chemotherapeutics: Bayesian Population Modeling and Dose Optimization. 38
26226448 2015
9
A randomized controlled trial assessing the effect of prescribed patient position changes during colonoscope withdrawal on adenoma detection. 38
24629419 2014
10
Transanal endoscopic microsurgery approach for rectal stump resection as an alternative to transperitoneal stump resection. 38
23188592 2013
11
Fecal microbiota transplantation: techniques, applications, and issues. 38
23101687 2012
12
Single nucleotide polymorphisms in C-type lectin genes, clustered in the IBD2 and IBD6 susceptibility loci, may play a role in the pathogenesis of inflammatory bowel diseases. 38
22664939 2012
13
Cerebral venous thrombosis in inflammatory bowel diseases: eight cases and literature review. 38
22017824 2011
14
Hepatosplenic T-cell lymphoma and inflammatory bowel disease. 38
21122554 2010
15
Characteristics and predictors of recurrence of anterior and intermediate uveitis in a Canadian referral centre. 38
20379299 2010
16
6-Thioguanine therapy in Crohn's disease--observational data in Swedish patients. 38
18799369 2009
17
MAST3: a novel IBD risk factor that modulates TLR4 signaling. 38
18650832 2008
18
An SNP linkage scan identifies significant Crohn's disease loci on chromosomes 13q13.3 and, in Jewish families, on 1p35.2 and 3q29. 38
18246054 2008
19
Hepatosplenic T cell lymphoma associated with infliximab use in young patients treated for inflammatory bowel disease. 38
17255842 2007
20
A functional candidate screen for coeliac disease genes. 38
16835590 2006
21
Haplotype-based association analysis of 56 functional candidate genes in the IBD6 locus on chromosome 19. 38
16570073 2006
22
Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations. 38
15788214 2005
23
Characterization of genotype-phenotype relationships and stratification by the CARD15 variant genotype for inflammatory bowel disease susceptibility loci using multiple short tandem repeat genetic markers. 38
15643611 2005
24
Inflammatory bowel disease is linked to 19p13 and associated with ICAM-1. 38
15290909 2004
25
Genetics of inflammatory bowel disease. 38
9682668 1998
26
Vesico-colic fistulae in the Grampian region: presentation, assessment, management and outcome. 38
9195812 1997
27
Serum lysozyme in Crohn's disease and ulcerative colitis. 38
609977 1977
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Variations for Inflammatory Bowel Disease 6

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Expression for Inflammatory Bowel Disease 6

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Search GEO for disease gene expression data for Inflammatory Bowel Disease 6.
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Pathways for Inflammatory Bowel Disease 6

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Pathways related to Inflammatory Bowel Disease 6 according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Innate Immune System 66
Show member pathways
 13.29 TLR4 NOD2 MYO9B KLRB1 IL12RB1 ICAM1
2
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 66
11.56 KLRB1 ICAM1 CLEC2D
3
Cytokine production by Th17 cells in CF (Mouse model) 22
Show member pathways
 11.3 TLR4 IL12RB1 ICAM1
4
HETE and HPETE biosynthesis and metabolism 22
Show member pathways
 10.75 CYP4F3 CYP4F2
5
Malaria 37
10.49 TLR4 KLRB1 ICAM1
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GO Terms for Inflammatory Bowel Disease 6

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Cellular components related to Inflammatory Bowel Disease 6 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.35 TLR4 NOD2 ICAM1 CLEC2D CD209
2 external side of plasma membrane GO:0009897 9.1 TLR4 IL12RB1 ICAM1 FCER2 CRLF1 CD209
3 membrane GO:0016020 10 TLR4 SNCA NOD2 MYO9B KLRB1 IL12RB1

Biological processes related to Inflammatory Bowel Disease 6 according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.67 TLR4 NOD2 ICAM1
2 cytokine-mediated signaling pathway GO:0019221 9.62 IL12RB1 ICAM1 FCER2 CRLF1
3 intracellular signal transduction GO:0035556 9.55 NOD2 MYO9B MAST3 DCLK3 CD209
4 positive regulation of interleukin-1 beta secretion GO:0050718 9.54 TLR4 NOD2
5 cellular response to interferon-gamma GO:0071346 9.54 TLR4 IL12RB1 ICAM1
6 positive regulation of interleukin-8 production GO:0032757 9.52 TLR4 NOD2
7 leukocyte cell-cell adhesion GO:0007159 9.51 ICAM1 CD209
8 positive regulation of interleukin-10 production GO:0032733 9.48 TLR4 NOD2
9 positive regulation of stress-activated MAPK cascade GO:0032874 9.46 TLR4 NOD2
10 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.43 TLR4 NOD2
11 leukotriene metabolic process GO:0006691 9.4 CYP4F3 CYP4F2
12 icosanoid metabolic process GO:0006690 9.26 CYP4F3 CYP4F2
13 leukotriene B4 catabolic process GO:0036101 8.96 CYP4F3 CYP4F2
14 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 8.8 TLR4 NOD2 FCER2

Molecular functions related to Inflammatory Bowel Disease 6 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane signaling receptor activity GO:0004888 9.35 TLR4 KLRB1 ICAM1 CLEC4A CLEC2D
2 mannose binding GO:0005537 9.26 CLEC4A CD209
3 leukotriene-B4 20-monooxygenase activity GO:0050051 9.16 CYP4F3 CYP4F2
4 carbohydrate binding GO:0030246 9.02 KLRB1 FCER2 CLEC4A CLEC2D CD209
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Sources for Inflammatory Bowel Disease 6

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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