IBD6
MCID: INF089
MIFTS: 28

Inflammatory Bowel Disease 6 (IBD6)

Categories: Blood diseases, Bone diseases, Gastrointestinal diseases, Genetic diseases, Immune diseases, Rare diseases

Aliases & Classifications for Inflammatory Bowel Disease 6

MalaCards integrated aliases for Inflammatory Bowel Disease 6:

Name: Inflammatory Bowel Disease 6 57 12 13 15 73
Ibd6 57 12

Classifications:



External Ids:

OMIM 57 606674
Disease Ontology 12 DOID:0110907
UMLS 73 C1847692

Summaries for Inflammatory Bowel Disease 6

Disease Ontology : 12 An inflammatory bowel disease that has material basis in variation in the chromosome region 19p13.

MalaCards based summary : Inflammatory Bowel Disease 6, also known as ibd6, is related to inflammatory bowel disease and perrault syndrome 1. An important gene associated with Inflammatory Bowel Disease 6 is IBD6 (Inflammatory Bowel Disease 6), and among its related pathways/superpathways are Innate Immune System and Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. Affiliated tissues include bone, and related phenotype is digestive/alimentary.

Description from OMIM: 606674

Related Diseases for Inflammatory Bowel Disease 6

Diseases in the Inflammatory Bowel Disease family:

Inflammatory Bowel Disease 11 Inflammatory Bowel Disease 1
Inflammatory Bowel Disease 2 Inflammatory Bowel Disease 3
Inflammatory Bowel Disease 7 Inflammatory Bowel Disease 5
Inflammatory Bowel Disease 8 Inflammatory Bowel Disease 6
Inflammatory Bowel Disease 4 Inflammatory Bowel Disease 9
Inflammatory Bowel Disease 10 Inflammatory Bowel Disease 12
Inflammatory Bowel Disease 13 Inflammatory Bowel Disease 14
Inflammatory Bowel Disease 15 Inflammatory Bowel Disease 16
Inflammatory Bowel Disease 17 Inflammatory Bowel Disease 18
Inflammatory Bowel Disease 19 Inflammatory Bowel Disease 20
Inflammatory Bowel Disease 21 Inflammatory Bowel Disease 22
Inflammatory Bowel Disease 23 Inflammatory Bowel Disease 24
Inflammatory Bowel Disease 25, Autosomal Recessive Inflammatory Bowel Disease 26
Inflammatory Bowel Disease 27 Inflammatory Bowel Disease 28, Autosomal Recessive
Inflammatory Bowel Disease 29 Inflammatory Bowel Disease 28
Inflammatory Bowel Disease 25

Diseases related to Inflammatory Bowel Disease 6 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 13)
# Related Disease Score Top Affiliating Genes
1 inflammatory bowel disease 31.8 IBD6 ICAM1 MYO9B NOD2 TLR4
2 perrault syndrome 1 11.1
3 ileocolitis 10.2 MYO9B NOD2
4 crohn's disease 10.1
5 pouchitis 10.1 NOD2 TLR4
6 colitis 10.0 MYO9B NOD2 TLR4
7 sarcoidosis 1 10.0 ICAM1 IL12RB1 NOD2
8 fungal keratitis 10.0 CD209 TLR4
9 ulcerative colitis 10.0 MYO9B NOD2 TLR4
10 chronic conjunctivitis 10.0 FCER2 ICAM1
11 spondylarthropathy 10.0 NOD2 TLR4
12 mycobacterium tuberculosis 1 10.0 CD209 IL12RB1 TLR4
13 lymphadenitis 9.7 CD209 ICAM1 IL12RB1 NOD2 TLR4

Graphical network of the top 20 diseases related to Inflammatory Bowel Disease 6:



Diseases related to Inflammatory Bowel Disease 6

Symptoms & Phenotypes for Inflammatory Bowel Disease 6

Clinical features from OMIM:

606674

MGI Mouse Phenotypes related to Inflammatory Bowel Disease 6:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.1 CLEC4A FCER2 ICAM1 NOD2 SNCA TLR4

Drugs & Therapeutics for Inflammatory Bowel Disease 6

Search Clinical Trials , NIH Clinical Center for Inflammatory Bowel Disease 6

Genetic Tests for Inflammatory Bowel Disease 6

Anatomical Context for Inflammatory Bowel Disease 6

MalaCards organs/tissues related to Inflammatory Bowel Disease 6:

41
Bone

Publications for Inflammatory Bowel Disease 6

Variations for Inflammatory Bowel Disease 6

Expression for Inflammatory Bowel Disease 6

Search GEO for disease gene expression data for Inflammatory Bowel Disease 6.

Pathways for Inflammatory Bowel Disease 6

GO Terms for Inflammatory Bowel Disease 6

Cellular components related to Inflammatory Bowel Disease 6 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane GO:0016020 9.8 CD209 CLEC2D CLEC4A CYP4F2 CYP4F3 DDX39A
2 cell surface GO:0009986 9.55 CD209 CLEC2D ICAM1 NOD2 TLR4
3 external side of plasma membrane GO:0009897 9.1 CD209 CRLF1 FCER2 ICAM1 IL12RB1 TLR4

Biological processes related to Inflammatory Bowel Disease 6 according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 intracellular signal transduction GO:0035556 9.86 CD209 MAST3 MYO9B NOD2
2 response to lipopolysaccharide GO:0032496 9.72 ICAM1 SNCA TLR4
3 cellular response to lipopolysaccharide GO:0071222 9.71 ICAM1 NOD2 TLR4
4 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.65 ICAM1 NOD2 TLR4
5 cytokine-mediated signaling pathway GO:0019221 9.56 CRLF1 FCER2 ICAM1 IL12RB1
6 positive regulation of interleukin-1 beta secretion GO:0050718 9.52 NOD2 TLR4
7 leukocyte cell-cell adhesion GO:0007159 9.51 CD209 ICAM1
8 cellular response to interferon-gamma GO:0071346 9.5 ICAM1 IL12RB1 TLR4
9 positive regulation of interleukin-8 production GO:0032757 9.49 NOD2 TLR4
10 positive regulation of interleukin-10 production GO:0032733 9.46 NOD2 TLR4
11 positive regulation of stress-activated MAPK cascade GO:0032874 9.43 NOD2 TLR4
12 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.4 NOD2 TLR4
13 leukotriene metabolic process GO:0006691 9.37 CYP4F2 CYP4F3
14 icosanoid metabolic process GO:0006690 9.16 CYP4F2 CYP4F3
15 leukotriene B4 catabolic process GO:0036101 8.96 CYP4F2 CYP4F3
16 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 8.8 FCER2 NOD2 TLR4

Molecular functions related to Inflammatory Bowel Disease 6 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mannose binding GO:0005537 9.37 CD209 CLEC4A
2 transmembrane signaling receptor activity GO:0004888 9.35 CLEC2D CLEC4A ICAM1 KLRB1 TLR4
3 leukotriene-B4 20-monooxygenase activity GO:0050051 9.32 CYP4F2 CYP4F3
4 20-aldehyde-leukotriene B4 20-monooxygenase activity GO:0097259 9.26 CYP4F2 CYP4F3
5 20-hydroxy-leukotriene B4 omega oxidase activity GO:0097258 9.16 CYP4F2 CYP4F3
6 carbohydrate binding GO:0030246 9.02 CD209 CLEC2D CLEC4A FCER2 KLRB1

Sources for Inflammatory Bowel Disease 6

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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