Inflammatory Bowel Disease 6 disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Inflammatory Bowel Disease 6

MalaCards integrated aliases for Inflammatory Bowel Disease 6:

Name: Inflammatory Bowel Disease 6 ⁵⁷ ¹² ¹³ ¹⁵ ⁷³

Ibd6 ⁵⁷ ¹²

Classifications:

MalaCards categories:
Global: Genetic diseases Rare diseases
Anatomical: Gastrointestinal diseases Bone diseases Blood diseases Immune diseases

See all MalaCards categories (disease lists)

External Ids:

OMIM ⁵⁷ 606674

Disease Ontology ¹² DOID:0110907

UMLS ⁷³ C1847692

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Summaries for Inflammatory Bowel Disease 6

Disease Ontology : ¹² An inflammatory bowel disease that has material basis in variation in the chromosome region 19p13.

MalaCards based summary : Inflammatory Bowel Disease 6, also known as ibd6, is related to inflammatory bowel disease and ileocolitis. An important gene associated with Inflammatory Bowel Disease 6 is IBD6 (Inflammatory Bowel Disease 6), and among its related pathways/superpathways are Innate Immune System and Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. Related phenotype is hematopoietic system.

Description from OMIM: 606674

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Related Diseases for Inflammatory Bowel Disease 6

Diseases in the Inflammatory Bowel Disease family:

Inflammatory Bowel Disease 11	Inflammatory Bowel Disease 1
Inflammatory Bowel Disease 2	Inflammatory Bowel Disease 3
Inflammatory Bowel Disease 7	Inflammatory Bowel Disease 5
Inflammatory Bowel Disease 8	Inflammatory Bowel Disease 6
Inflammatory Bowel Disease 4	Inflammatory Bowel Disease 9
Inflammatory Bowel Disease 10	Inflammatory Bowel Disease 12
Inflammatory Bowel Disease 13	Inflammatory Bowel Disease 14
Inflammatory Bowel Disease 15	Inflammatory Bowel Disease 16
Inflammatory Bowel Disease 17	Inflammatory Bowel Disease 18
Inflammatory Bowel Disease 19	Inflammatory Bowel Disease 20
Inflammatory Bowel Disease 21	Inflammatory Bowel Disease 22
Inflammatory Bowel Disease 23	Inflammatory Bowel Disease 24
Inflammatory Bowel Disease 25, Autosomal Recessive	Inflammatory Bowel Disease 26
Inflammatory Bowel Disease 27	Inflammatory Bowel Disease 28, Autosomal Recessive
Inflammatory Bowel Disease 28	Inflammatory Bowel Disease 25

Diseases related to Inflammatory Bowel Disease 6 via text searches within MalaCards or GeneCards Suite gene sharing:

#	Related Disease	Score	Top Affiliating Genes
1	inflammatory bowel disease	31.1	IBD6 ICAM1 MYO9B NOD2 TLR4 TPMT
2	ileocolitis	10.5	MYO9B NOD2
3	inflammatory bowel disease 5	10.3	MYO9B NOD2
4	pouchitis	10.3	NOD2 TLR4
5	sarcoidosis 1	10.0	ICAM1 IL12RB1 NOD2
6	crohn's disease	9.9
7	ulcerative colitis	9.8	MYO9B NOD2 TLR4
8	mycobacterium tuberculosis 1	9.8	CD209 IL12RB1 TLR4
9	colitis	9.6	MYO9B NOD2 TLR4
10	lymphadenitis	9.1	CD209 ICAM1 IL12RB1 NOD2 TLR4

Graphical network of the top 20 diseases related to Inflammatory Bowel Disease 6:

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Symptoms & Phenotypes for Inflammatory Bowel Disease 6

Clinical features from OMIM:

606674

MGI Mouse Phenotypes related to Inflammatory Bowel Disease 6:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system	MP:0005397	9.28	CLEC4A CRLF1 FCER2 ICAM1 IL12RB1 MYO9B

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Drugs & Therapeutics for Inflammatory Bowel Disease 6

Search Clinical Trials , NIH Clinical Center for Inflammatory Bowel Disease 6

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Genetic Tests for Inflammatory Bowel Disease 6

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Anatomical Context for Inflammatory Bowel Disease 6

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Publications for Inflammatory Bowel Disease 6

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Genes for Inflammatory Bowel Disease 6

Genes related to Inflammatory Bowel Disease 6 (1 elite genes):

(show all 18)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	IBD6	Inflammatory Bowel Disease 6	Genetic Locus	58.6	Susceptibility factor ⁵⁷ GeneCards inferred via : Gene name (show sections)
2	TPMT	Thiopurine S-Methyltransferase	Protein Coding	16.94	GeneCards inferred via : Publications (show sections)
3	CYP4F3	Cytochrome P450 Family 4 Subfamily F Member 3	Protein Coding	16.44	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
4	MYO9B	Myosin IXB	Protein Coding	16.29	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
5	CYP4F2	Cytochrome P450 Family 4 Subfamily F Member 2	Protein Coding	15.93	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
6	CLEC2D	C-Type Lectin Domain Family 2 Member D	Protein Coding	15.29	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
7	NOD2	Nucleotide Binding Oligomerization Domain Containing 2	Protein Coding	15.04	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
8	IL12RB1	Interleukin 12 Receptor Subunit Beta 1	Protein Coding	13.96	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
9	FCER2	Fc Fragment Of IgE Receptor II	Protein Coding	13.93	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
10	TLR4	Toll Like Receptor 4	Protein Coding	13.92	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
11	CRLF1	Cytokine Receptor Like Factor 1	Protein Coding	13.8	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
12	KLRB1	Killer Cell Lectin Like Receptor B1	Protein Coding	13.78	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
13	ICAM1	Intercellular Adhesion Molecule 1	Protein Coding	13.73	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
14	SNCA	Synuclein Alpha	Protein Coding	13.65	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
15	CD209	CD209 Molecule	Protein Coding	13.61	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
16	MAST3	Microtubule Associated Serine/Threonine Kinase 3	Protein Coding	7.62	DISEASES inferred ¹⁵
17	DDX39A	DExD-Box Helicase 39A	Protein Coding	6.83	DISEASES inferred ¹⁵
18	CLEC4A	C-Type Lectin Domain Family 4 Member A	Protein Coding	5.14	DISEASES inferred ¹⁵

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Variations for Inflammatory Bowel Disease 6

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Expression for Inflammatory Bowel Disease 6

Search GEO for disease gene expression data for Inflammatory Bowel Disease 6.

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Pathways for Inflammatory Bowel Disease 6

Pathways related to Inflammatory Bowel Disease 6 according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁶ Show member pathways Immune System ⁶⁶ Neutrophil degranulation ⁶⁶	13.29	CD209 CLEC2D CLEC4A CRLF1 FCER2 ICAM1
2	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell ⁶⁶	11.56	CLEC2D ICAM1 KLRB1
3	Cytokine production by Th17 cells in CF (Mouse model) ²² Show member pathways Cytokine production by Th17 cells in CF ²²	11.3	ICAM1 IL12RB1 TLR4
4	HETE and HPETE biosynthesis and metabolism ²² Show member pathways lipoxin biosynthesis ¹ resolvin D biosynthesis ¹ Synthesis of Hepoxilins (HX) and Trioxilins (TrX) ⁶⁶	10.75	CYP4F2 CYP4F3
5	Malaria ³⁷	10.49	ICAM1 KLRB1 TLR4

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GO Terms for Inflammatory Bowel Disease 6

Cellular components related to Inflammatory Bowel Disease 6 according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cell surface	GO:0009986	9.35	CD209 CLEC2D ICAM1 NOD2 TLR4
2	external side of plasma membrane	GO:0009897	8.92	CD209 FCER2 ICAM1 TLR4
3	membrane	GO:0016020	10	CD209 CLEC2D CLEC4A CYP4F2 CYP4F3 DDX39A

Biological processes related to Inflammatory Bowel Disease 6 according to GeneCards Suite gene sharing:

(show all 12)

#	Name	GO ID	Score	Top Affiliating Genes
1	cytokine-mediated signaling pathway	GO:0019221	9.67	CRLF1 FCER2 ICAM1 IL12RB1
2	positive regulation of NF-kappaB transcription factor activity	GO:0051092	9.61	ICAM1 NOD2 TLR4
3	positive regulation of interleukin-8 production	GO:0032757	9.51	NOD2 TLR4
4	leukocyte cell-cell adhesion	GO:0007159	9.49	CD209 ICAM1
5	positive regulation of interleukin-1 beta secretion	GO:0050718	9.48	NOD2 TLR4
6	positive regulation of interleukin-10 production	GO:0032733	9.46	NOD2 TLR4
7	positive regulation of stress-activated MAPK cascade	GO:0032874	9.4	NOD2 TLR4
8	leukotriene metabolic process	GO:0006691	9.32	CYP4F2 CYP4F3
9	positive regulation of cytokine production involved in inflammatory response	GO:1900017	9.26	NOD2 TLR4
10	icosanoid metabolic process	GO:0006690	9.16	CYP4F2 CYP4F3
11	leukotriene B4 catabolic process	GO:0036101	8.96	CYP4F2 CYP4F3
12	positive regulation of nitric-oxide synthase biosynthetic process	GO:0051770	8.8	FCER2 NOD2 TLR4

Molecular functions related to Inflammatory Bowel Disease 6 according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	transmembrane signaling receptor activity	GO:0004888	9.8	CLEC2D CLEC4A ICAM1 KLRB1 TLR4
2	leukotriene-B4 20-monooxygenase activity	GO:0050051	9.37	CYP4F2 CYP4F3
3	tocopherol omega-hydroxylase activity	GO:0052870	9.32	CYP4F2 CYP4F3
4	alpha-tocopherol omega-hydroxylase activity	GO:0052871	9.26	CYP4F2 CYP4F3
5	20-hydroxy-leukotriene B4 omega oxidase activity	GO:0097258	9.16	CYP4F2 CYP4F3
6	carbohydrate binding	GO:0030246	9.02	CD209 CLEC2D CLEC4A FCER2 KLRB1
7	20-aldehyde-leukotriene B4 20-monooxygenase activity	GO:0097259	8.96	CYP4F2 CYP4F3

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Sources for Inflammatory Bowel Disease 6

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

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⁹ Cosmic

¹⁰ dbSNP

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²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

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³⁰ HGMD

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³² HPO

³³ ICD10

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³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

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⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

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⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

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⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

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⁷¹ TGDB

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⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia