Inflammatory Bowel Disease 6 disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Inflammatory Bowel Disease 6

MalaCards integrated aliases for Inflammatory Bowel Disease 6:

Name: Inflammatory Bowel Disease 6 ⁵⁸ ¹² ¹³ ¹⁵ ⁷⁴

Ibd6 ⁵⁸ ¹²

Classifications:

MalaCards categories:
Global: Genetic diseases Rare diseases
Anatomical: Gastrointestinal diseases Bone diseases Blood diseases Immune diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0110907

OMIM ⁵⁸ 606674

UMLS ⁷⁴ C1847692

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Summaries for Inflammatory Bowel Disease 6

Disease Ontology : ¹² An inflammatory bowel disease that has material basis in variation in the chromosome region 19p13.

MalaCards based summary : Inflammatory Bowel Disease 6, also known as ibd6, is related to inflammatory bowel disease and cone-rod dystrophy and hearing loss 2. An important gene associated with Inflammatory Bowel Disease 6 is IBD6 (Inflammatory Bowel Disease 6), and among its related pathways/superpathways are Innate Immune System and Tuberculosis. Affiliated tissues include bone, and related phenotype is digestive/alimentary.

Description from OMIM: 606674

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Related Diseases for Inflammatory Bowel Disease 6

Diseases in the Inflammatory Bowel Disease family:

Inflammatory Bowel Disease 11	Inflammatory Bowel Disease 1
Inflammatory Bowel Disease 2	Inflammatory Bowel Disease 3
Inflammatory Bowel Disease 7	Inflammatory Bowel Disease 5
Inflammatory Bowel Disease 8	Inflammatory Bowel Disease 6
Inflammatory Bowel Disease 4	Inflammatory Bowel Disease 9
Inflammatory Bowel Disease 10	Inflammatory Bowel Disease 12
Inflammatory Bowel Disease 13	Inflammatory Bowel Disease 14
Inflammatory Bowel Disease 15	Inflammatory Bowel Disease 16
Inflammatory Bowel Disease 17	Inflammatory Bowel Disease 18
Inflammatory Bowel Disease 19	Inflammatory Bowel Disease 20
Inflammatory Bowel Disease 21	Inflammatory Bowel Disease 22
Inflammatory Bowel Disease 23	Inflammatory Bowel Disease 24
Inflammatory Bowel Disease 25, Autosomal Recessive	Inflammatory Bowel Disease 26
Inflammatory Bowel Disease 27	Inflammatory Bowel Disease 28, Autosomal Recessive
Inflammatory Bowel Disease 29	Inflammatory Bowel Disease 28
Inflammatory Bowel Disease 25

Diseases related to Inflammatory Bowel Disease 6 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 14)

#	Related Disease	Score	Top Affiliating Genes
1	inflammatory bowel disease	11.7
2	cone-rod dystrophy and hearing loss 2	11.1
3	ileocolitis	10.3	MYO9B NOD2
4	pouchitis	10.2	NOD2 TLR4
5	inflammatory bowel disease 2	10.1
6	inflammatory bowel disease 5	10.1
7	crohn's disease	10.1
8	colitis	10.0	MYO9B NOD2 TLR4
9	fungal keratitis	10.0	CD209 TLR4
10	chronic conjunctivitis	10.0	FCER2 ICAM1
11	ulcerative colitis	10.0	MYO9B NOD2 TLR4
12	spondylarthropathy	9.9	NOD2 TLR4
13	mycobacterium tuberculosis 1	9.9	CD209 IL12RB1 TLR4
14	lymphadenitis	9.5	CD209 ICAM1 IL12RB1 NOD2 TLR4

Graphical network of the top 20 diseases related to Inflammatory Bowel Disease 6:

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Symptoms & Phenotypes for Inflammatory Bowel Disease 6

Clinical features from OMIM:

606674

MGI Mouse Phenotypes related to Inflammatory Bowel Disease 6:

⁴⁷

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	digestive/alimentary	MP:0005381	9.1	CLEC4A FCER2 ICAM1 NOD2 SNCA TLR4

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Drugs & Therapeutics for Inflammatory Bowel Disease 6

Search Clinical Trials , NIH Clinical Center for Inflammatory Bowel Disease 6

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Genetic Tests for Inflammatory Bowel Disease 6

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Anatomical Context for Inflammatory Bowel Disease 6

MalaCards organs/tissues related to Inflammatory Bowel Disease 6:

⁴²

Bone

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Publications for Inflammatory Bowel Disease 6

Articles related to Inflammatory Bowel Disease 6:

#	Title	Authors	Year
1	Single nucleotide polymorphisms in C-type lectin genes, clustered in the IBD2 and IBD6 susceptibility loci, may play a role in the pathogenesis of inflammatory bowel diseases. ( 22664939 )	Wolfkamp SC...te Velde AA	2012
2	Haplotype-based association analysis of 56 functional candidate genes in the IBD6 locus on chromosome 19. ( 16570073 )	Tello-Ruiz MK...Rioux JD	2006
3	The IBD6 Crohn's disease locus demonstrates complex interactions with CARD15 and IBD5 disease-associated variants. ( 12928481 )	van Heel DA...Lench NJ	2003

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Genes for Inflammatory Bowel Disease 6

Genes related to Inflammatory Bowel Disease 6 (1 elite genes):

(show all 17)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	IBD6	Inflammatory Bowel Disease 6	Genetic Locus	58.53	Susceptibility factor ⁵⁸ GeneCards inferred via : Gene name (show sections)
2	CYP4F3	Cytochrome P450 Family 4 Subfamily F Member 3	Protein Coding	16.3	DISEASES inferred ¹⁵
3	MYO9B	Myosin IXB	Protein Coding	16.26	DISEASES inferred ¹⁵
4	CYP4F2	Cytochrome P450 Family 4 Subfamily F Member 2	Protein Coding	15.82	DISEASES inferred ¹⁵
5	CLEC2D	C-Type Lectin Domain Family 2 Member D	Protein Coding	15.08	DISEASES inferred ¹⁵
6	NOD2	Nucleotide Binding Oligomerization Domain Containing 2	Protein Coding	14.94	DISEASES inferred ¹⁵
7	IL12RB1	Interleukin 12 Receptor Subunit Beta 1	Protein Coding	13.85	DISEASES inferred ¹⁵
8	CRLF1	Cytokine Receptor Like Factor 1	Protein Coding	13.74	DISEASES inferred ¹⁵
9	FCER2	Fc Fragment Of IgE Receptor II	Protein Coding	13.73	DISEASES inferred ¹⁵
10	TLR4	Toll Like Receptor 4	Protein Coding	13.7	DISEASES inferred ¹⁵
11	KLRB1	Killer Cell Lectin Like Receptor B1	Protein Coding	13.69	DISEASES inferred ¹⁵
12	ICAM1	Intercellular Adhesion Molecule 1	Protein Coding	13.67	DISEASES inferred ¹⁵
13	SNCA	Synuclein Alpha	Protein Coding	13.59	DISEASES inferred ¹⁵
14	CD209	CD209 Molecule	Protein Coding	13.47	DISEASES inferred ¹⁵
15	MAST3	Microtubule Associated Serine/Threonine Kinase 3	Protein Coding	7.36	DISEASES inferred ¹⁵
16	DDX39A	DExD-Box Helicase 39A	Protein Coding	6.67	DISEASES inferred ¹⁵
17	CLEC4A	C-Type Lectin Domain Family 4 Member A	Protein Coding	4.96	DISEASES inferred ¹⁵

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Variations for Inflammatory Bowel Disease 6

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Expression for Inflammatory Bowel Disease 6

Search GEO for disease gene expression data for Inflammatory Bowel Disease 6.

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Pathways for Inflammatory Bowel Disease 6

Pathways related to Inflammatory Bowel Disease 6 according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁷ Show member pathways Immune System ⁶⁷ Neutrophil degranulation ⁶⁷	13.29	CD209 CLEC2D CLEC4A CRLF1 FCER2 ICAM1
2	Tuberculosis ³⁸	11.8	CD209 NOD2 TLR4
3	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell ⁶⁷	11.56	CLEC2D ICAM1 KLRB1
4	Cytokine production by Th17 cells in CF (Mouse model) ²³ Show member pathways Cytokine production by Th17 cells in CF ²³	11.3	ICAM1 IL12RB1 TLR4
5	HETE and HPETE biosynthesis and metabolism ²³ Show member pathways lipoxin biosynthesis ¹ resolvin D biosynthesis ¹ Synthesis of Hepoxilins (HX) and Trioxilins (TrX) ⁶⁷	10.75	CYP4F2 CYP4F3
6	Malaria ³⁸	10.49	ICAM1 KLRB1 TLR4

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GO Terms for Inflammatory Bowel Disease 6

Cellular components related to Inflammatory Bowel Disease 6 according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	membrane	GO:0016020	9.8	CD209 CLEC2D CLEC4A CYP4F2 CYP4F3 DDX39A
2	cell surface	GO:0009986	9.55	CD209 CLEC2D ICAM1 NOD2 TLR4
3	external side of plasma membrane	GO:0009897	9.1	CD209 CRLF1 FCER2 ICAM1 IL12RB1 TLR4

Biological processes related to Inflammatory Bowel Disease 6 according to GeneCards Suite gene sharing:

(show all 16)

#	Name	GO ID	Score	Top Affiliating Genes
1	intracellular signal transduction	GO:0035556	9.86	CD209 MAST3 MYO9B NOD2
2	response to lipopolysaccharide	GO:0032496	9.72	ICAM1 SNCA TLR4
3	cellular response to lipopolysaccharide	GO:0071222	9.71	ICAM1 NOD2 TLR4
4	positive regulation of NF-kappaB transcription factor activity	GO:0051092	9.65	ICAM1 NOD2 TLR4
5	cytokine-mediated signaling pathway	GO:0019221	9.56	CRLF1 FCER2 ICAM1 IL12RB1
6	positive regulation of interleukin-1 beta secretion	GO:0050718	9.52	NOD2 TLR4
7	leukocyte cell-cell adhesion	GO:0007159	9.51	CD209 ICAM1
8	cellular response to interferon-gamma	GO:0071346	9.5	ICAM1 IL12RB1 TLR4
9	positive regulation of interleukin-8 production	GO:0032757	9.49	NOD2 TLR4
10	positive regulation of interleukin-10 production	GO:0032733	9.46	NOD2 TLR4
11	positive regulation of stress-activated MAPK cascade	GO:0032874	9.43	NOD2 TLR4
12	positive regulation of cytokine production involved in inflammatory response	GO:1900017	9.4	NOD2 TLR4
13	leukotriene metabolic process	GO:0006691	9.37	CYP4F2 CYP4F3
14	icosanoid metabolic process	GO:0006690	9.16	CYP4F2 CYP4F3
15	leukotriene B4 catabolic process	GO:0036101	8.96	CYP4F2 CYP4F3
16	positive regulation of nitric-oxide synthase biosynthetic process	GO:0051770	8.8	FCER2 NOD2 TLR4

Molecular functions related to Inflammatory Bowel Disease 6 according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	transmembrane signaling receptor activity	GO:0004888	9.35	CLEC2D CLEC4A ICAM1 KLRB1 TLR4
2	mannose binding	GO:0005537	9.26	CD209 CLEC4A
3	leukotriene-B4 20-monooxygenase activity	GO:0050051	9.16	CYP4F2 CYP4F3
4	carbohydrate binding	GO:0030246	9.02	CD209 CLEC2D CLEC4A FCER2 KLRB1

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Sources for Inflammatory Bowel Disease 6

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

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¹⁶ DrugBank

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¹⁹ FDA Approved Drugs

²⁰ FMA

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ Genetics Home Reference

²⁷ GenomeRNAi

²⁸ GEO DataSets

²⁹ GO

³⁰ GTR

³¹ HGMD

³² HMDB

³³ HPO

³⁴ ICD10

³⁵ ICD10 via Orphanet

³⁶ ICD9CM

³⁷ IUPHAR

³⁸ KEGG

³⁹ LifeMap

⁴⁰ LncRNADisease

⁴¹ LOVD

⁴² MalaCards

⁴³ MedGen

⁴⁴ MedlinePlus

⁴⁵ MeSH

⁴⁶ MESH via Orphanet

⁴⁷ MGI

⁴⁸ miR2Disease

⁴⁹ NCBI Bookshelf

⁵⁰ NCI

⁵¹ NCIt

⁵² NDF-RT

⁵³ NIH Clinical Center

⁵⁴ NIH Rare Diseases

⁵⁵ NINDS

⁵⁶ Novoseek

⁵⁷ Novus Biologicals

⁵⁸ OMIM

⁵⁹ OMIM via Orphanet

⁶⁰ Orphanet

⁶¹ PathCards

⁶² PharmGKB

⁶³ PubMed

⁶⁴ PubMed Health

⁶⁵ QIAGEN

⁶⁶ R&D Systems

⁶⁷ Reactome

⁶⁸ Sino Biological

⁶⁹ SNOMED-CT

⁷⁰ SNOMED-CT via HPO

⁷¹ SNOMED-CT via Orphanet

⁷² TGDB

⁷³ Tocris

⁷⁴ UMLS

⁷⁵ UMLS via Orphanet

⁷⁶ UniProtKB/Swiss-Prot

⁷⁷ Wikipedia

Inflammatory Bowel Disease 6 (IBD6)

Aliases & Classifications for Inflammatory Bowel Disease 6

MalaCards integrated aliases for Inflammatory Bowel Disease 6:

Classifications:

External Ids:

Summaries for Inflammatory Bowel Disease 6

Related Diseases for Inflammatory Bowel Disease 6

Diseases in the Inflammatory Bowel Disease family:

Diseases related to Inflammatory Bowel Disease 6 via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to Inflammatory Bowel Disease 6:

Symptoms & Phenotypes for Inflammatory Bowel Disease 6

Clinical features from OMIM:

MGI Mouse Phenotypes related to Inflammatory Bowel Disease 6:

Drugs & Therapeutics for Inflammatory Bowel Disease 6

Genetic Tests for Inflammatory Bowel Disease 6

Anatomical Context for Inflammatory Bowel Disease 6

MalaCards organs/tissues related to Inflammatory Bowel Disease 6:

Publications for Inflammatory Bowel Disease 6

Articles related to Inflammatory Bowel Disease 6:

Genes for Inflammatory Bowel Disease 6

Genes related to Inflammatory Bowel Disease 6 (1 elite genes):

Variations for Inflammatory Bowel Disease 6

Expression for Inflammatory Bowel Disease 6

Pathways for Inflammatory Bowel Disease 6

Pathways related to Inflammatory Bowel Disease 6 according to GeneCards Suite gene sharing:

GO Terms for Inflammatory Bowel Disease 6

Cellular components related to Inflammatory Bowel Disease 6 according to GeneCards Suite gene sharing:

Biological processes related to Inflammatory Bowel Disease 6 according to GeneCards Suite gene sharing:

Molecular functions related to Inflammatory Bowel Disease 6 according to GeneCards Suite gene sharing:

Sources for Inflammatory Bowel Disease 6