Inflammatory Bowel Disease 9 disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Inflammatory Bowel Disease 9

MalaCards integrated aliases for Inflammatory Bowel Disease 9:

Name: Inflammatory Bowel Disease 9 ⁵⁷ ¹² ¹³ ¹⁵ ⁷³

Ibd9 ⁵⁷ ¹²

Classifications:

MalaCards categories:
Global: Genetic diseases Rare diseases
Anatomical: Gastrointestinal diseases Bone diseases Blood diseases Immune diseases

See all MalaCards categories (disease lists)

External Ids:

OMIM ⁵⁷ 608448

Disease Ontology ¹² DOID:0110886

UMLS ⁷³ C1838019

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Summaries for Inflammatory Bowel Disease 9

Disease Ontology : ¹² An inflammatory bowel disease that has material basis in variation in the chromosome region 3p26.

MalaCards based summary : Inflammatory Bowel Disease 9, also known as ibd9, is related to inflammatory bowel disease and lymphoproliferative syndrome, x-linked, 2. An important gene associated with Inflammatory Bowel Disease 9 is IBD9 (Inflammatory Bowel Disease 9), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Immune response IFN gamma signaling pathway. Related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Description from OMIM: 608448

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Related Diseases for Inflammatory Bowel Disease 9

Diseases in the Inflammatory Bowel Disease family:

Inflammatory Bowel Disease 11	Inflammatory Bowel Disease 1
Inflammatory Bowel Disease 2	Inflammatory Bowel Disease 3
Inflammatory Bowel Disease 7	Inflammatory Bowel Disease 5
Inflammatory Bowel Disease 8	Inflammatory Bowel Disease 6
Inflammatory Bowel Disease 4	Inflammatory Bowel Disease 9
Inflammatory Bowel Disease 10	Inflammatory Bowel Disease 12
Inflammatory Bowel Disease 13	Inflammatory Bowel Disease 14
Inflammatory Bowel Disease 15	Inflammatory Bowel Disease 16
Inflammatory Bowel Disease 17	Inflammatory Bowel Disease 18
Inflammatory Bowel Disease 19	Inflammatory Bowel Disease 20
Inflammatory Bowel Disease 21	Inflammatory Bowel Disease 22
Inflammatory Bowel Disease 23	Inflammatory Bowel Disease 24
Inflammatory Bowel Disease 25, Autosomal Recessive	Inflammatory Bowel Disease 26
Inflammatory Bowel Disease 27	Inflammatory Bowel Disease 28, Autosomal Recessive
Inflammatory Bowel Disease 28	Inflammatory Bowel Disease 25

Diseases related to Inflammatory Bowel Disease 9 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 11)

#	Related Disease	Score	Top Affiliating Genes
1	inflammatory bowel disease	28.4	CCL20 IBD9 IL11 IL18 NOD1 NOD2
2	lymphoproliferative syndrome, x-linked, 2	10.1	NOD1 NOD2
3	inflammatory bowel disease 1	10.0	NOD1 NOD2
4	blau syndrome	10.0	NOD1 NOD2
5	sapho syndrome	9.8	IL18 NOD2
6	listeria meningitis	9.8	CCL20 IL18
7	acute graft versus host disease	9.7	IL18 NOD2
8	lymphadenitis	9.6	IL18 NOD2
9	sarcoidosis 1	9.5	IL18 NOD2
10	rheumatoid arthritis	8.7	CCL20 IL11 IL18
11	inflammatory bowel disease 3	8.2	CCL20 IL11 IL18 NOD1 NOD2

Graphical network of the top 20 diseases related to Inflammatory Bowel Disease 9:

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Symptoms & Phenotypes for Inflammatory Bowel Disease 9

Clinical features from OMIM:

608448

GenomeRNAi Phenotypes related to Inflammatory Bowel Disease 9 according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Synthetic lethal with MLN4924 (a NAE inhibitor)	GR00250-A-1	9.53	NOD1 NOD2 IL18 MLH1
2	Synthetic lethal with MLN4924 (a NAE inhibitor)	GR00250-A-2	9.53	MLH1 NOD1 NOD2 IL18

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Drugs & Therapeutics for Inflammatory Bowel Disease 9

Search Clinical Trials , NIH Clinical Center for Inflammatory Bowel Disease 9

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Genetic Tests for Inflammatory Bowel Disease 9

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Anatomical Context for Inflammatory Bowel Disease 9

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Publications for Inflammatory Bowel Disease 9

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Genes for Inflammatory Bowel Disease 9

Genes related to Inflammatory Bowel Disease 9 (1 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	IBD9	Inflammatory Bowel Disease 9	Genetic Locus	58.62	Susceptibility factor ⁵⁷ GeneCards inferred via : Gene name (show sections)
2	NOD1	Nucleotide Binding Oligomerization Domain Containing 1	Protein Coding	15.63	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
3	IL11	Interleukin 11	Protein Coding	15.13	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
4	NOD2	Nucleotide Binding Oligomerization Domain Containing 2	Protein Coding	14.71	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
5	IL18	Interleukin 18	Protein Coding	14.3	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
6	MLH1	MutL Homolog 1	Protein Coding	14.29	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
7	CCL20	C-C Motif Chemokine Ligand 20	Protein Coding	5.04	DISEASES inferred ¹⁵

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Variations for Inflammatory Bowel Disease 9

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Expression for Inflammatory Bowel Disease 9

Search GEO for disease gene expression data for Inflammatory Bowel Disease 9.

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Pathways for Inflammatory Bowel Disease 9

Pathways related to Inflammatory Bowel Disease 9 according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Cytokine Signaling in Immune system ⁶⁶ Show member pathways Signaling by Interleukins ⁶⁶	12.66	CCL20 IL11 IL18 NOD1 NOD2
2	Immune response IFN gamma signaling pathway ²² Show member pathways IFN-gamma pathway ¹	11.56	CCL20 IL11 IL18
3	TNF signaling pathway ³⁷	11.47	CCL20 NOD2
4	Shigellosis ³⁷	11.22	NOD1 NOD2
5	Rheumatoid arthritis ³⁷	11.09	CCL20 IL11 IL18
6	Interleukin-10 signaling ⁶⁶	11.01	CCL20 IL18
7	Ovarian tumor domain proteases ⁶⁶	10.82	NOD1 NOD2
8	Nucleotide-binding Oligomerization Domain (NOD) pathway ¹	10.41	IL18 NOD1 NOD2

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GO Terms for Inflammatory Bowel Disease 9

Biological processes related to Inflammatory Bowel Disease 9 according to GeneCards Suite gene sharing:

(show all 29)

#	Name	GO ID	Score	Top Affiliating Genes
1	regulation of signaling receptor activity	GO:0010469	9.8	CCL20 IL11 IL18
2	cytokine-mediated signaling pathway	GO:0019221	9.74	CCL20 IL11 IL18
3	positive regulation of ERK1 and ERK2 cascade	GO:0070374	9.71	CCL20 NOD1 NOD2
4	defense response to bacterium	GO:0042742	9.69	CCL20 NOD1 NOD2
5	negative regulation of inflammatory response	GO:0050728	9.64	NOD1 NOD2
6	interleukin-1-mediated signaling pathway	GO:0070498	9.64	NOD1 NOD2
7	negative regulation of NF-kappaB transcription factor activity	GO:0032088	9.63	NOD1 NOD2
8	regulation of inflammatory response	GO:0050727	9.63	NOD1 NOD2
9	protein complex oligomerization	GO:0051259	9.62	NOD1 NOD2
10	inflammatory response	GO:0006954	9.62	CCL20 IL18 NOD1 NOD2
11	cellular response to organic cyclic compound	GO:0071407	9.61	IL18 NOD2
12	positive regulation of JNK cascade	GO:0046330	9.61	NOD1 NOD2
13	JNK cascade	GO:0007254	9.6	NOD1 NOD2
14	positive regulation of interleukin-6 production	GO:0032755	9.59	NOD1 NOD2
15	regulation of cytokine production	GO:0001817	9.58	NOD1 NOD2
16	positive regulation of tumor necrosis factor production	GO:0032760	9.58	NOD1 NOD2
17	signaling	GO:0023052	9.56	NOD1 NOD2
18	regulation of I-kappaB kinase/NF-kappaB signaling	GO:0043122	9.55	NOD1 NOD2
19	negative regulation of immune response	GO:0050777	9.52	NOD1 NOD2
20	nucleotide-binding oligomerization domain containing signaling pathway	GO:0070423	9.49	NOD1 NOD2
21	positive regulation of stress-activated MAPK cascade	GO:0032874	9.48	NOD1 NOD2
22	positive regulation of nitric-oxide synthase biosynthetic process	GO:0051770	9.46	CCL20 NOD2
23	positive regulation of interleukin-17 production	GO:0032740	9.43	IL18 NOD2
24	positive regulation of interleukin-1 beta production	GO:0032731	9.4	NOD1 NOD2
25	detection of bacterium	GO:0016045	9.37	NOD1 NOD2
26	positive regulation of dendritic cell antigen processing and presentation	GO:0002606	9.26	NOD1 NOD2
27	cellular response to muramyl dipeptide	GO:0071225	9.16	NOD1 NOD2
28	detection of biotic stimulus	GO:0009595	8.96	NOD1 NOD2
29	positive regulation of NIK/NF-kappaB signaling	GO:1901224	8.8	IL18 NOD1 NOD2

Molecular functions related to Inflammatory Bowel Disease 9 according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cytokine activity	GO:0005125	9.33	CCL20 IL11 IL18
2	peptidoglycan binding	GO:0042834	8.96	NOD1 NOD2
3	CARD domain binding	GO:0050700	8.62	NOD1 NOD2

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Sources for Inflammatory Bowel Disease 9

¹ BioSystems

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