Inflammatory Bowel Disease 9 disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

IBD9 MCID: INF092 MIFTS: 38	Inflammatory Bowel Disease 9 (IBD9) Categories: Blood diseases, Bone diseases, Gastrointestinal diseases, Genetic diseases, Immune diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs Expand all tables

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Aliases & Classifications for Inflammatory Bowel Disease 9

MalaCards integrated aliases for Inflammatory Bowel Disease 9:

Name: Inflammatory Bowel Disease 9 ⁵⁷ ¹² ¹³ ¹⁵ ⁷²

Ibd9 ⁵⁷ ¹²

Classifications:

MalaCards categories:
Global: Genetic diseases Rare diseases
Anatomical: Gastrointestinal diseases Bone diseases Blood diseases Immune diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0110886

OMIM ⁵⁷ 608448 PS266600

UMLS ⁷² C1838019

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Summaries for Inflammatory Bowel Disease 9

Disease Ontology : ¹² An inflammatory bowel disease that has material basis in variation in the chromosome region 3p26.

MalaCards based summary : Inflammatory Bowel Disease 9, also known as ibd9, is related to colitis and inflammatory bowel disease. An important gene associated with Inflammatory Bowel Disease 9 is IBD9 (Inflammatory Bowel Disease 9), and among its related pathways/superpathways are Innate Immune System and Activated TLR4 signalling. The drugs Antibodies and Immunoglobulins have been mentioned in the context of this disorder. Affiliated tissues include liver, and related phenotypes are hematopoietic system and digestive/alimentary

More information from OMIM: 608448 PS266600

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Related Diseases for Inflammatory Bowel Disease 9

Diseases in the Inflammatory Bowel Disease family:

Inflammatory Bowel Disease 11	Inflammatory Bowel Disease 1
Inflammatory Bowel Disease 2	Inflammatory Bowel Disease 3
Inflammatory Bowel Disease 7	Inflammatory Bowel Disease 5
Inflammatory Bowel Disease 8	Inflammatory Bowel Disease 6
Inflammatory Bowel Disease 4	Inflammatory Bowel Disease 9
Inflammatory Bowel Disease 10	Inflammatory Bowel Disease 12
Inflammatory Bowel Disease 13	Inflammatory Bowel Disease 14
Inflammatory Bowel Disease 15	Inflammatory Bowel Disease 16
Inflammatory Bowel Disease 17	Inflammatory Bowel Disease 18
Inflammatory Bowel Disease 19	Inflammatory Bowel Disease 20
Inflammatory Bowel Disease 21	Inflammatory Bowel Disease 22
Inflammatory Bowel Disease 23	Inflammatory Bowel Disease 24
Inflammatory Bowel Disease 25, Autosomal Recessive	Inflammatory Bowel Disease 26
Inflammatory Bowel Disease 27	Inflammatory Bowel Disease 28, Autosomal Recessive
Inflammatory Bowel Disease 29	Inflammatory Bowel Disease 28
Inflammatory Bowel Disease 25	Rare Inflammatory Bowel Disease

Diseases related to Inflammatory Bowel Disease 9 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 61)

#	Related Disease	Score	Top Affiliating Genes
1	colitis	28.6	TLR9 TLR4 NOD2 MLH1
2	inflammatory bowel disease	27.9	TLR5 TLR4 TLR2 NOD2 NOD1 IL18
3	lymphoproliferative syndrome, x-linked, 2	10.5	NOD2 NOD1
4	sapho syndrome	10.2	NOD2 IL18
5	superficial basal cell carcinoma	10.1	TLR9 TLR8 TLR7
6	neurosyphilis	10.0	TLR6 TLR2 TLR1
7	mucocutaneous leishmaniasis	10.0	TLR9 TLR3
8	juvenile nasopharyngeal angiofibroma	10.0	TLR9 TLR7 TLR3
9	lyme disease	10.0	TLR6 TLR2 TLR1
10	pouchitis	9.9	TLR4 NOD2
11	ocular toxoplasmosis	9.9	TLR9 TLR5 TLR1 NOD2
12	urethritis	9.9	TLR6 TLR1
13	colonic disease	9.9	TLR9 NOD2 MLH1
14	variola major	9.9	TLR4 TLR3
15	viral infectious disease	9.8	TLR9 TLR8 TLR7 TLR3
16	genital herpes	9.7	TLR9 TLR2 IL18
17	lymphadenitis	9.7	TLR4 NOD2 IL18
18	prosthetic joint infection	9.7	TLR4 TLR2
19	inflammatory bowel disease 3	9.6	NOD2 NOD1 IL18 IL11 CCL20
20	bronchiolitis	9.6	TLR9 TLR4 TLR10
21	trench fever	9.6	TLR4 TLR2
22	pulmonary tuberculosis	9.6	TLR9 TLR2 IL18
23	spondylarthropathy	9.5	TLR4 TLR2 NOD2
24	fungal keratitis	9.5	TLR4 TLR2
25	oral cavity cancer	9.5	TLR9 TLR6 TLR2 IL18
26	legionellosis	9.4	TLR5 TLR4 TLR2
27	mouth disease	9.4	TLR9 TLR4 TLR3
28	asthma	9.4	TLR9 TLR6 NOD1 IL18 IL11
29	aspergillosis	9.4	TLR9 TLR4 TLR2
30	acute cervicitis	9.4	TLR4 TLR2
31	toxoplasmosis	9.4	TLR9 TLR4 TLR2
32	myositis fibrosa	9.3	TLR9 TLR4 TLR2
33	middle ear disease	9.3	TLR9 TLR4 TLR2
34	immune system disease	9.3	TLR9 TLR6 TLR5 TLR3 TLR10 TLR1
35	keratitis, hereditary	9.3	TLR9 TLR4 TLR2
36	primary bacterial infectious disease	9.3	TLR9 TLR4 TLR2
37	cutaneous leishmaniasis	9.3	TLR9 TLR4 TLR2
38	behcet syndrome	9.3	TLR9 TLR4 NOD2 IL18
39	leishmaniasis	9.3	TLR9 TLR4 TLR2
40	visceral leishmaniasis	9.3	TLR9 TLR4 TLR2
41	proteasome-associated autoinflammatory syndrome 1	9.3	TLR4 TLR2 IL18
42	penicilliosis	9.3	TLR6 TLR4 TLR2 TLR1
43	ileitis	9.3	TLR5 TLR4 TLR2 NOD2
44	pelvic inflammatory disease	9.3	TLR6 TLR4 TLR2 TLR1
45	intestinal disease	9.2	TLR9 TLR4 NOD2 MLH1
46	periodontitis	9.2	TLR9 TLR4 TLR2
47	gastrointestinal system disease	9.2	TLR9 TLR4 NOD2 MLH1
48	ulcerative colitis	9.2	TLR4 NOD2 MLH1
49	suppurative otitis media	9.1	TLR9 TLR5 TLR4 TLR2
50	q fever	9.1	TLR4 TLR2 TLR10 TLR1 NOD2

Graphical network of the top 20 diseases related to Inflammatory Bowel Disease 9:

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Symptoms & Phenotypes for Inflammatory Bowel Disease 9

Clinical features from OMIM:

608448

MGI Mouse Phenotypes related to Inflammatory Bowel Disease 9:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system	MP:0005397	10	BDKRB2 IL18 MLH1 NOD1 NOD2 TLR1
2	digestive/alimentary	MP:0005381	9.86	BDKRB2 IL18 MLH1 NOD2 TLR2 TLR4
3	homeostasis/metabolism	MP:0005376	9.7	BDKRB2 IL18 MLH1 NOD2 TLR2 TLR3
4	immune system	MP:0005387	9.47	BDKRB2 IL18 MLH1 NOD1 NOD2 TLR1

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Drugs & Therapeutics for Inflammatory Bowel Disease 9

Drugs for Inflammatory Bowel Disease 9 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

#	Name	Status	Phase	Clinical Trials	Cas Number	PubChem Id
1	Antibodies
2	Immunoglobulins

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Quantification of GADD34 Expression in Rheumatoid Arthritis	Completed	NCT02401165

Search NIH Clinical Center for Inflammatory Bowel Disease 9

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Genetic Tests for Inflammatory Bowel Disease 9

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Anatomical Context for Inflammatory Bowel Disease 9

MalaCards organs/tissues related to Inflammatory Bowel Disease 9:

⁴¹

Liver

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Publications for Inflammatory Bowel Disease 9

Articles related to Inflammatory Bowel Disease 9:

(show all 16)

#	Title	Authors	PMID	Year
1	Evidence for an inflammatory bowel disease locus on chromosome 3p26: linkage, transmission/disequilibrium and partitioning of linkage. ⁸	Duerr RH...Weeks DE	12354785	2002
2	Fine mapping of the chromosome 3p susceptibility locus in inflammatory bowel disease. ⁸	Hampe J...Schreiber S	11156639	2001
3	Two stage genome-wide search in inflammatory bowel disease provides evidence for susceptibility loci on chromosomes 3, 7 and 12. ⁸	Satsangi J...Jewell DP	8841195	1996
4	The diagnostic performance of (99m)Tc-HMPAO radiolabeled leucocytes scintigraphy in the investigations of infection. A single center experience. ³⁸	Notopoulos A...Papazoglou K	26665208	2015
5	Predicting inadequate bowel preparation for colonoscopy in participants receiving split-dose bowel preparation: development and validation of a prediction score. ³⁸	Dik VK...Colonoscopy Quality Initiative	25600879	2015
6	Reduction of CD68+ macrophages and decreased IL-17 expression in intestinal mucosa of patients with inflammatory bowel disease strongly correlate with endoscopic response and mucosal healing following infliximab therapy. ³⁸	Caprioli F...Reali E	23448791	2013
7	Infliximab safety profile and long-term applicability in inflammatory bowel disease: 9-year experience in clinical practice. ³⁸	Zabana Y...Gassull MA	20002026	2010
8	Evaluation of the MLH1 I219V alteration in DNA mismatch repair activity and ulcerative colitis. ³⁸	Plotz G...Schmidt C	18200512	2008
9	Immune system alterations in patients with inflammatory bowel disease during remission. ³⁸	Sventoraityte J...Tamosiunas V	18277086	2008
10	Novel genetic markers in inflammatory bowel disease. ³⁸	Rodriguez-Bores L...Yamamoto-Furusho JK	17948929	2007
11	Clinical utility of wireless capsule endoscopy: experience with 200 cases. ³⁸	Tatar EL...Pitchumoni CS	16394875	2006
12	Association of cystic fibrosis with abnormalities in fatty acid metabolism. ³⁸	Freedman SD...O'Sullivan BP	14762183	2004
13	Autoimmunity in Wiskott-Aldrich syndrome: risk factors, clinical features, and outcome in a single-center cohort of 55 patients. ³⁸	Dupuis-Girod S...Fischer A	12728121	2003
14	[Social consequences and quality of life in patients with chronic inflammatory bowel disease]. ³⁸	Frenzer A...Hammer B	8701273	1996
15	Prospective study of the effect of resection of the rectum on male sexual function. ³⁸	Fazio VW...Montague D	7190753	1980
16	Liver copper content in patients with inflammatory bowel disease and associated liver disorders. ³⁸	Ritland S...Steinnes E	531503	1979

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Genes for Inflammatory Bowel Disease 9

Genes related to Inflammatory Bowel Disease 9 (1 elite genes):

(show all 18)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	IBD9	Inflammatory Bowel Disease 9	Genetic Locus	58.52	Susceptibility factor ⁵⁷ GeneCards inferred via : Gene name (show sections)
2	BDKRB2	Bradykinin Receptor B2	Protein Coding	16.9	GeneCards inferred via : Publications (show sections)
3	NOD1	Nucleotide Binding Oligomerization Domain Containing 1	Protein Coding	14.98	DISEASES inferred ¹⁵
4	IL11	Interleukin 11	Protein Coding	14.51	DISEASES inferred ¹⁵
5	NOD2	Nucleotide Binding Oligomerization Domain Containing 2	Protein Coding	14.08	DISEASES inferred ¹⁵
6	TLR10	Toll Like Receptor 10	Protein Coding	13.92	DISEASES inferred ¹⁵
7	TLR6	Toll Like Receptor 6	Protein Coding	13.89	DISEASES inferred ¹⁵
8	TLR8	Toll Like Receptor 8	Protein Coding	13.88	DISEASES inferred ¹⁵
9	TLR1	Toll Like Receptor 1	Protein Coding	13.84	DISEASES inferred ¹⁵
10	TLR5	Toll Like Receptor 5	Protein Coding	13.82	DISEASES inferred ¹⁵
11	TLR7	Toll Like Receptor 7	Protein Coding	13.7	DISEASES inferred ¹⁵
12	TLR3	Toll Like Receptor 3	Protein Coding	13.69	DISEASES inferred ¹⁵
13	IL18	Interleukin 18	Protein Coding	13.65	DISEASES inferred ¹⁵
14	TLR9	Toll Like Receptor 9	Protein Coding	13.61	DISEASES inferred ¹⁵
15	MLH1	MutL Homolog 1	Protein Coding	13.53	DISEASES inferred ¹⁵
16	TLR2	Toll Like Receptor 2	Protein Coding	13.42	DISEASES inferred ¹⁵
17	TLR4	Toll Like Receptor 4	Protein Coding	13.16	DISEASES inferred ¹⁵
18	CCL20	C-C Motif Chemokine Ligand 20	Protein Coding	4.36	DISEASES inferred ¹⁵

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Variations for Inflammatory Bowel Disease 9

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Expression for Inflammatory Bowel Disease 9

Search GEO for disease gene expression data for Inflammatory Bowel Disease 9.

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Pathways for Inflammatory Bowel Disease 9

Pathways related to Inflammatory Bowel Disease 9 according to GeneCards Suite gene sharing:

(show all 27)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁶ Show member pathways Immune System ⁶⁶ Neutrophil degranulation ⁶⁶	14.02	TLR9 TLR8 TLR7 TLR6 TLR5 TLR4
2	Activated TLR4 signalling ⁶⁶ Show member pathways activated TAK1 mediates p38 MAPK activation ⁶⁶ Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon ⁶⁶ IRAK2 mediated activation of TAK1 complex ⁶⁶ IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation ⁶⁶ JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 ⁶⁶ MAP kinase activation in TLR cascade ⁶⁶ MyD88 cascade initiated on plasma membrane ⁶⁶ MyD88 dependent cascade initiated on endosome ⁶⁶ MyD88-independent TLR3/TLR4 cascade ⁶⁶ MyD88-Mal cascade initiated on plasma membrane ⁶⁶ Regulation of TLR by endogenous ligand ⁶⁶ TICAM1 deficiency - HSE ⁶⁶ Toll Like Receptor 10 (TLR10) Cascade ⁶⁶ Toll Like Receptor 2 (TLR2) Cascade ⁶⁶ Toll Like Receptor 3 (TLR3) Cascade ⁶⁶ Toll Like Receptor 4 (TLR4) Cascade ⁶⁶ Toll Like Receptor 5 (TLR5) Cascade ⁶⁶ Toll Like Receptor 7/8 (TLR7/8) Cascade ⁶⁶ Toll Like Receptor 9 (TLR9) Cascade ⁶⁶ Toll Like Receptor TLR1-TLR2 Cascade ⁶⁶ Toll Like Receptor TLR6-TLR2 Cascade ⁶⁶ Toll-Like Receptors Cascades ⁶⁶ TRAF3 deficiency - HSE ⁶⁶ TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation ⁶⁶ TRAF6 mediated induction of TAK1 complex ⁶⁶ TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling ⁶⁶ Trafficking and processing of endosomal TLR ⁶⁶ Transfer of LPS from LBP carrier to CD14 ⁶⁶ TRIF-mediated programmed cell death ⁶⁶ TRIF-mediated TLR3/TLR4 signaling ⁶⁶	13.62	TLR9 TLR8 TLR7 TLR6 TLR5 TLR4
3	Akt Signaling ⁶⁴ Show member pathways p38 Signaling ⁶⁴ Tec Kinases Signaling ⁶⁴	13.47	TLR9 TLR8 TLR7 TLR6 TLR5 TLR4
4	IL-2 Pathway ⁶⁴ Show member pathways ErbB Family Pathway ⁶⁴ ErbB2-ErbB3 Heterodimers ⁶⁴ ErbB4 Pathway ⁶⁴ Growth Hormone Signaling ⁶⁴ HMGB1 Pathway ⁶⁴ IL-4 Pathway ⁶⁴ LPS Stimulated MAPK Signaling ⁶⁴ PACAP Signaling ⁶⁴ PI3K Signaling in B-Lymphocyte ⁶⁴ Prolactin Signaling ⁶⁴ Thrombopoietin Pathway ⁶⁴ TREM1 Pathway ⁶⁴ UVC-Induced MAPK Signaling ⁶⁴	13.26	TLR9 TLR8 TLR7 TLR6 TLR5 TLR4
5	NF-KappaB Family Pathway ⁶⁴ Show member pathways NF-KappaB (p50-p65) Pathway ⁶⁴	12.8	TLR9 TLR8 TLR7 TLR6 TLR5 TLR4
6	TRAF Pathway ⁶⁴ Show member pathways 14-3-3 Induced Apoptosis ⁶⁴ TNF Superfamily Pathway ⁶⁴ Toll-Like Receptors Pathway ⁶⁴	12.73	TLR9 TLR8 TLR7 TLR6 TLR5 TLR4
7	NF-kappaB Signaling ⁴	12.65	TLR9 TLR8 TLR7 TLR6 TLR3 TLR2
8	Th17 cell differentiation ³⁷ Show member pathways IL-22 Pathway ⁶⁴ Immune response IL-22 signaling pathway ²² Inflammatory bowel disease (IBD) ³⁷ Th1 and Th2 cell differentiation ³⁷	12.55	TLR5 TLR4 TLR2 NOD2 IL18
9	VEGF Pathway (Qiagen) ⁶⁴ Show member pathways CCKBR-Gastrin Stimulated Signaling ⁶⁴ Development VEGF-family signaling ²² Neurophilin interactions with VEGF and VEGFR ⁶⁶ VEGF Family Ligands and Receptor Interactions ⁶⁴	12.5	TLR9 TLR8 TLR7 TLR6 TLR5 TLR4
10	Toll-like Receptor Signaling Pathway ³⁷ ¹ Show member pathways Chagas disease (American trypanosomiasis) ³⁷ Hepatitis B ³⁷ Hepatitis C ³⁷ NOD-like Receptor Signaling Pathways ⁶⁵ Regulation of toll-like receptor signaling pathway ¹	12.4	TLR9 TLR8 TLR7 TLR6 TLR5 TLR4
11	Antigen processing-Cross presentation ⁶⁶ Show member pathways Cross-presentation of particulate exogenous antigens (phagosomes) ⁶⁶ Endosomal/Vacuolar pathway ⁶⁶ ER-Phagosome pathway ⁶⁶ Immune response Antigen presentation by MHC class I ²²	12.38	TLR6 TLR4 TLR2 TLR1
12	Tuberculosis ³⁷	12.32	TLR9 TLR6 TLR4 TLR2 TLR1 NOD2
13	G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins ²² Show member pathways G-protein signaling G-Protein alpha-12 signaling pathway ²²	12.3	TLR9 TLR8 TLR7 TLR6 TLR5 TLR4
14	Diseases associated with the TLR signaling cascade ⁶⁶ Show member pathways Diseases of Immune System ⁶⁶ Interleukin-1 Induced Activation of NF-kappa-B ¹ IRAK1 recruits IKK complex ⁶⁶ IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation ⁶⁶ IRAK4 deficiency (TLR2/4) ⁶⁶ IRAK4 deficiency (TLR5) ⁶⁶ MyD88 deficiency (TLR2/4) ⁶⁶ MyD88 deficiency (TLR5) ⁶⁶ Simplified Depiction of MYD88 Distinct Input-Output Pathway ¹ TLR4 Signaling and Tolerance ¹ Toll-like Receptor Signaling ¹	12.3	TLR9 TLR8 TLR7 TLR6 TLR5 TLR4
15	Bacterial infections in CF airways ²² Show member pathways IL-1 beta-dependent CFTR expression ²² Immune response Bacterial infections in normal airways ²² Immune response TLR signaling pathways ²²	12.17	TLR9 TLR8 TLR7 TLR6 TLR5 TLR4
16	MAPK Pathway ⁷¹ Show member pathways Toll-like Receptor Pathway ⁷¹	12.16	TLR9 TLR8 TLR7 TLR6 TLR5 TLR4
17	Phagocytosis of Microbes ⁶⁴	12.03	TLR9 TLR8 TLR7 TLR6 TLR5 TLR4
18	Microglia Activation During Neuroinflammation: Overview ⁶⁵ Show member pathways Microglia Activation During Neuroinflammation: Microglia Activation ⁶⁵	12.01	TLR6 TLR4 TLR2 TLR1
19	Th1 Differentiation Pathway ⁶⁵ Show member pathways IL27-mediated signaling events ¹ Th17 Differentiation Pathway ⁶⁵	12.01	TLR9 TLR8 TLR7 TLR6 TLR5 TLR4
20	Rheumatoid arthritis ³⁷	11.94	TLR4 TLR2 IL18 IL11 CCL20
21	Colorectal Cancer Metastasis ⁶⁴	11.91	TLR9 TLR8 TLR7 TLR6 TLR5 TLR4
22	Salmonella infection (KEGG) ³⁷	11.72	TLR5 TLR4 IL18
23	Legionellosis ³⁷	11.64	TLR5 TLR4 TLR2 IL18
24	Malaria ³⁷	11.58	TLR9 TLR4 TLR2 IL18
25	MSP-RON Signaling ⁶⁴	11.48	TLR4 TLR2 IL18
26	Nucleotide-binding Oligomerization Domain (NOD) pathway ¹	11.41	NOD2 NOD1 IL18
27	IL1 and megakaryocytes in obesity ¹	11.17	TLR2 TLR1 IL18

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GO Terms for Inflammatory Bowel Disease 9

Cellular components related to Inflammatory Bowel Disease 9 according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	integral component of plasma membrane	GO:0005887	9.95	TLR6 TLR4 TLR3 TLR2 TLR10 TLR1
2	cytoplasmic vesicle	GO:0031410	9.88	TLR9 TLR7 TLR6 TLR2 TLR1
3	endosome	GO:0005768	9.83	TLR9 TLR7 TLR4 TLR3 BDKRB2
4	phagocytic vesicle membrane	GO:0030670	9.54	TLR6 TLR2 TLR1
5	endosome membrane	GO:0010008	9.35	TLR9 TLR8 TLR7 TLR4 TLR3
6	early phagosome	GO:0032009	9.26	TLR9 TLR7
7	Toll-like receptor 1-Toll-like receptor 2 protein complex	GO:0035354	9.16	TLR2 TLR1
8	endolysosome membrane	GO:0036020	8.92	TLR9 TLR8 TLR7 TLR3
9	membrane	GO:0016020	10.3	TLR9 TLR8 TLR7 TLR6 TLR5 TLR4
10	plasma membrane	GO:0005886	10.1	TLR9 TLR8 TLR7 TLR6 TLR5 TLR4

Biological processes related to Inflammatory Bowel Disease 9 according to GeneCards Suite gene sharing:

(show top 50) (show all 86)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of chemokine production	GO:0032722	9.98	TLR9 TLR7 TLR4 TLR3 TLR2
2	cellular response to interferon-gamma	GO:0071346	9.97	TLR4 TLR3 TLR2 CCL20
3	microglial cell activation	GO:0001774	9.97	TLR8 TLR7 TLR6 TLR3 TLR2
4	positive regulation of interferon-beta production	GO:0032728	9.95	TLR9 TLR4 TLR3 TLR2
5	positive regulation of interleukin-8 production	GO:0032757	9.95	TLR9 TLR7 TLR5 TLR4 TLR3 TLR2
6	activation of MAPK activity	GO:0000187	9.94	TLR4 NOD2 NOD1
7	positive regulation of interleukin-12 production	GO:0032735	9.94	TLR9 TLR4 TLR3 TLR2
8	positive regulation of interleukin-10 production	GO:0032733	9.93	TLR9 TLR4 TLR2 NOD2
9	positive regulation of nitric-oxide synthase biosynthetic process	GO:0051770	9.92	TLR9 TLR4 TLR2 NOD2
10	I-kappaB phosphorylation	GO:0007252	9.92	TLR9 TLR7 TLR4 TLR3 TLR2
11	positive regulation of NIK/NF-kappaB signaling	GO:1901224	9.92	TLR9 TLR7 TLR4 TLR3 TLR2 NOD2
12	positive regulation of interferon-gamma biosynthetic process	GO:0045078	9.91	TLR9 TLR8 TLR7 TLR3
13	positive regulation of interleukin-8 biosynthetic process	GO:0045416	9.91	TLR9 TLR8 TLR7 TLR4
14	regulation of cytokine secretion	GO:0050707	9.91	TLR9 TLR8 TLR6 TLR5 TLR2 TLR10
15	positive regulation of nitric oxide biosynthetic process	GO:0045429	9.89	TLR6 TLR5 TLR4
16	positive regulation of interferon-beta biosynthetic process	GO:0045359	9.88	TLR9 TLR8 TLR7 TLR4 TLR3
17	lipopolysaccharide-mediated signaling pathway	GO:0031663	9.87	TLR4 TLR2 IL18
18	positive regulation of interleukin-1 beta secretion	GO:0050718	9.87	TLR8 TLR4 NOD2
19	positive regulation of toll-like receptor signaling pathway	GO:0034123	9.87	TLR9 TLR5 TLR3 TLR2
20	positive regulation of interferon-alpha biosynthetic process	GO:0045356	9.86	TLR9 TLR8 TLR7 TLR3
21	positive regulation of interleukin-6 production	GO:0032755	9.86	TLR9 TLR8 TLR7 TLR4 TLR3 TLR2
22	TRIF-dependent toll-like receptor signaling pathway	GO:0035666	9.85	TLR6 TLR4 TLR3
23	positive regulation of stress-activated MAPK cascade	GO:0032874	9.85	TLR4 NOD2 NOD1
24	positive regulation of cytokine production involved in inflammatory response	GO:1900017	9.84	TLR6 TLR4 NOD2
25	toll-like receptor 9 signaling pathway	GO:0034162	9.83	TLR9 TLR8 TLR7
26	cell activation	GO:0001775	9.83	TLR6 TLR2 TLR1
27	toll-like receptor signaling pathway	GO:0002224	9.81	TLR9 TLR8 TLR7 TLR6 TLR4 TLR3
28	nucleotide-binding oligomerization domain containing signaling pathway	GO:0070423	9.76	NOD2 NOD1
29	necroptotic process	GO:0070266	9.76	TLR4 TLR3
30	activation of NF-kappaB-inducing kinase activity	GO:0007250	9.76	TLR6 TLR3
31	positive regulation of macrophage activation	GO:0043032	9.76	TLR6 TLR4
32	positive regulation of interleukin-8 secretion	GO:2000484	9.76	TLR2 TLR1
33	positive regulation of reactive oxygen species biosynthetic process	GO:1903428	9.76	TLR6 TLR4
34	maintenance of gastrointestinal epithelium	GO:0030277	9.76	TLR9 NOD2
35	positive regulation of interleukin-17 production	GO:0032740	9.75	NOD2 IL18
36	response to molecule of bacterial origin	GO:0002237	9.75	TLR9 TLR2
37	positive regulation of tumor necrosis factor biosynthetic process	GO:0042535	9.75	TLR4 TLR1
38	positive regulation of granulocyte macrophage colony-stimulating factor production	GO:0032725	9.75	TLR9 IL18
39	MyD88-independent toll-like receptor signaling pathway	GO:0002756	9.75	TLR4 TLR3
40	macrophage activation	GO:0042116	9.75	TLR4 TLR1
41	T-helper 1 type immune response	GO:0042088	9.74	TLR4 IL18
42	positive regulation of interleukin-1 beta production	GO:0032731	9.74	NOD2 NOD1
43	cellular response to lipoteichoic acid	GO:0071223	9.74	TLR4 TLR2
44	detection of bacterium	GO:0016045	9.74	NOD2 NOD1
45	cellular response to muramyl dipeptide	GO:0071225	9.74	NOD2 NOD1
46	interleukin-1 beta secretion	GO:0050702	9.74	TLR6 TLR4
47	cellular response to oxidised low-density lipoprotein particle stimulus	GO:0140052	9.73	TLR6 TLR4
48	positive regulation of NLRP3 inflammasome complex assembly	GO:1900227	9.73	TLR6 TLR4
49	positive regulation of interleukin-6 biosynthetic process	GO:0045410	9.73	TLR6 TLR1
50	positive regulation of dendritic cell antigen processing and presentation	GO:0002606	9.73	NOD2 NOD1

Molecular functions related to Inflammatory Bowel Disease 9 according to GeneCards Suite gene sharing:

(show all 13)

#	Name	GO ID	Score	Top Affiliating Genes
1	identical protein binding	GO:0042802	9.95	TLR6 TLR4 TLR3 TLR2 TLR10 TLR1
2	protein heterodimerization activity	GO:0046982	9.88	TLR6 TLR4 TLR2 TLR1 BDKRB2
3	double-stranded RNA binding	GO:0003725	9.63	TLR8 TLR7 TLR3
4	signaling receptor activity	GO:0038023	9.63	TLR8 TLR6 TLR4 TLR3 TLR2 TLR1
5	CARD domain binding	GO:0050700	9.52	NOD2 NOD1
6	interleukin-1 receptor binding	GO:0005149	9.51	TLR9 TLR5
7	peptidoglycan binding	GO:0042834	9.5	TLR2 NOD2 NOD1
8	siRNA binding	GO:0035197	9.49	TLR9 TLR7
9	lipopolysaccharide receptor activity	GO:0001875	9.43	TLR4 TLR2
10	lipopeptide binding	GO:0071723	9.43	TLR6 TLR2 TLR1
11	Toll-like receptor 2 binding	GO:0035663	9.37	TLR6 TLR1
12	transmembrane signaling receptor activity	GO:0004888	9.28	TLR9 TLR8 TLR7 TLR6 TLR5 TLR4
13	signaling pattern recognition receptor activity	GO:0008329	9.26	TLR9 TLR8 TLR7 TLR2

Sources

Sources for Inflammatory Bowel Disease 9

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

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Inflammatory Bowel Disease 9 (IBD9)

Aliases & Classifications for Inflammatory Bowel Disease 9

MalaCards integrated aliases for Inflammatory Bowel Disease 9:

Classifications:

External Ids:

Summaries for Inflammatory Bowel Disease 9

Related Diseases for Inflammatory Bowel Disease 9

Diseases in the Inflammatory Bowel Disease family:

Diseases related to Inflammatory Bowel Disease 9 via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to Inflammatory Bowel Disease 9:

Symptoms & Phenotypes for Inflammatory Bowel Disease 9

Clinical features from OMIM:

MGI Mouse Phenotypes related to Inflammatory Bowel Disease 9:

Drugs & Therapeutics for Inflammatory Bowel Disease 9

Drugs for Inflammatory Bowel Disease 9 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Genetic Tests for Inflammatory Bowel Disease 9

Anatomical Context for Inflammatory Bowel Disease 9

MalaCards organs/tissues related to Inflammatory Bowel Disease 9:

Publications for Inflammatory Bowel Disease 9

Articles related to Inflammatory Bowel Disease 9:

Genes for Inflammatory Bowel Disease 9

Genes related to Inflammatory Bowel Disease 9 (1 elite genes):

Variations for Inflammatory Bowel Disease 9

Expression for Inflammatory Bowel Disease 9

Pathways for Inflammatory Bowel Disease 9

Pathways related to Inflammatory Bowel Disease 9 according to GeneCards Suite gene sharing:

GO Terms for Inflammatory Bowel Disease 9

Cellular components related to Inflammatory Bowel Disease 9 according to GeneCards Suite gene sharing:

Biological processes related to Inflammatory Bowel Disease 9 according to GeneCards Suite gene sharing:

Molecular functions related to Inflammatory Bowel Disease 9 according to GeneCards Suite gene sharing:

Sources for Inflammatory Bowel Disease 9