Inflammatory Bowel Disease 9 disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Inflammatory Bowel Disease 9

MalaCards integrated aliases for Inflammatory Bowel Disease 9:

Name: Inflammatory Bowel Disease 9 ⁵⁶ ¹² ¹³ ¹⁵ ⁷¹

Ibd9 ⁵⁶ ¹²

Classifications:

MalaCards categories:
Global: Genetic diseases Rare diseases
Anatomical: Gastrointestinal diseases Bone diseases Blood diseases Immune diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0110886

OMIM ⁵⁶ 608448

OMIM Phenotypic Series ⁵⁶ PS266600

UMLS ⁷¹ C1838019

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Summaries for Inflammatory Bowel Disease 9

Disease Ontology : ¹² An inflammatory bowel disease that has material basis in variation in the chromosome region 3p26.

MalaCards based summary : Inflammatory Bowel Disease 9, also known as ibd9, is related to inflammatory bowel disease and inflammatory bowel disease 3. An important gene associated with Inflammatory Bowel Disease 9 is IBD9 (Inflammatory Bowel Disease 9), and among its related pathways/superpathways are Development Endothelin-1/EDNRA signaling and Immune response Fc epsilon RI pathway. The drugs Antibodies and Immunoglobulins have been mentioned in the context of this disorder. Affiliated tissues include liver and bone.

More information from OMIM: 608448 PS266600

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Related Diseases for Inflammatory Bowel Disease 9

Diseases in the Inflammatory Bowel Disease family:

Inflammatory Bowel Disease 11	Inflammatory Bowel Disease 1
Inflammatory Bowel Disease 2	Inflammatory Bowel Disease 3
Inflammatory Bowel Disease 7	Inflammatory Bowel Disease 5
Inflammatory Bowel Disease 8	Inflammatory Bowel Disease 6
Inflammatory Bowel Disease 4	Inflammatory Bowel Disease 9
Inflammatory Bowel Disease 10	Inflammatory Bowel Disease 12
Inflammatory Bowel Disease 13	Inflammatory Bowel Disease 14
Inflammatory Bowel Disease 15	Inflammatory Bowel Disease 16
Inflammatory Bowel Disease 17	Inflammatory Bowel Disease 18
Inflammatory Bowel Disease 19	Inflammatory Bowel Disease 20
Inflammatory Bowel Disease 21	Inflammatory Bowel Disease 22
Inflammatory Bowel Disease 23	Inflammatory Bowel Disease 24
Inflammatory Bowel Disease 25, Autosomal Recessive	Inflammatory Bowel Disease 26
Inflammatory Bowel Disease 27	Inflammatory Bowel Disease 28, Autosomal Recessive
Inflammatory Bowel Disease 29	Inflammatory Bowel Disease 28
Inflammatory Bowel Disease 25	Rare Inflammatory Bowel Disease

Diseases related to Inflammatory Bowel Disease 9 via text searches within MalaCards or GeneCards Suite gene sharing:

#	Related Disease	Score	Top Affiliating Genes
1	inflammatory bowel disease	28.6	NOD2 MST1 IL12B IBD9
2	inflammatory bowel disease 3	10.0	NOD2 IL12B
3	colitis	9.9
4	inflammatory bowel disease 1	9.8	PLA2G4F NOD2
5	inflammatory bowel disease 5	9.8	P4HA2 NOD2
6	ileocolitis	9.6	PLA2G4F NOD2 DNAJC17
7	sclerosing cholangitis	9.3	NOD2 MST1

Graphical network of the top 20 diseases related to Inflammatory Bowel Disease 9:

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Symptoms & Phenotypes for Inflammatory Bowel Disease 9

Clinical features from OMIM:

608448

Sources

Drugs & Therapeutics for Inflammatory Bowel Disease 9

Drugs for Inflammatory Bowel Disease 9 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

#	Name	Status	Phase	Clinical Trials	Cas Number	PubChem Id
1	Antibodies
2	Immunoglobulins

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Quantification of GADD34 Expression in Rheumatoid Arthritis	Completed	NCT02401165

Search NIH Clinical Center for Inflammatory Bowel Disease 9

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Genetic Tests for Inflammatory Bowel Disease 9

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Anatomical Context for Inflammatory Bowel Disease 9

MalaCards organs/tissues related to Inflammatory Bowel Disease 9:

⁴⁰

Liver, Bone

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Publications for Inflammatory Bowel Disease 9

Articles related to Inflammatory Bowel Disease 9:

(show all 18)

#	Title	Authors	PMID	Year
1	Evidence for an inflammatory bowel disease locus on chromosome 3p26: linkage, transmission/disequilibrium and partitioning of linkage. ⁵⁶	Duerr RH...Weeks DE	12354785	2002
2	Fine mapping of the chromosome 3p susceptibility locus in inflammatory bowel disease. ⁵⁶	Hampe J...Schreiber S	11156639	2001
3	Two stage genome-wide search in inflammatory bowel disease provides evidence for susceptibility loci on chromosomes 3, 7 and 12. ⁵⁶	Satsangi J...Jewell DP	8841195	1996
4	[A multicenter study of the condition of children's rheumatic disease associated medical resources in Fujian province]. ⁶¹	Yi CL...Xiao JH	31795556	2019
5	Lymphomatoid Papulosis Type B in a Patient with Crohn's Disease Treated with TNF-Alpha Inhibitors Infliximab and Adalimumab. ⁶¹	Medvecz M...Marschalko M	31542070	2019
6	The diagnostic performance of (99m)Tc-HMPAO radiolabeled leucocytes scintigraphy in the investigations of infection. A single center experience. ⁶¹	Notopoulos A...Papazoglou K	26665208	2015
7	Predicting inadequate bowel preparation for colonoscopy in participants receiving split-dose bowel preparation: development and validation of a prediction score. ⁶¹	Dik VK...Colonoscopy Quality Initiative	25600879	2015
8	Reduction of CD68+ macrophages and decreased IL-17 expression in intestinal mucosa of patients with inflammatory bowel disease strongly correlate with endoscopic response and mucosal healing following infliximab therapy. ⁶¹	Caprioli F...Reali E	23448791	2013
9	Infliximab safety profile and long-term applicability in inflammatory bowel disease: 9-year experience in clinical practice. ⁶¹	Zabana Y...Gassull MA	20002026	2010
10	Evaluation of the MLH1 I219V alteration in DNA mismatch repair activity and ulcerative colitis. ⁶¹	Plotz G...Schmidt C	18200512	2008
11	Immune system alterations in patients with inflammatory bowel disease during remission. ⁶¹	Sventoraityte J...Tamosiunas V	18277086	2008
12	Novel genetic markers in inflammatory bowel disease. ⁶¹	Rodriguez-Bores L...Yamamoto-Furusho JK	17948929	2007
13	Clinical utility of wireless capsule endoscopy: experience with 200 cases. ⁶¹	Tatar EL...Pitchumoni CS	16394875	2006
14	Association of cystic fibrosis with abnormalities in fatty acid metabolism. ⁶¹	Freedman SD...O'Sullivan BP	14762183	2004
15	Autoimmunity in Wiskott-Aldrich syndrome: risk factors, clinical features, and outcome in a single-center cohort of 55 patients. ⁶¹	Dupuis-Girod S...Fischer A	12728121	2003
16	[Social consequences and quality of life in patients with chronic inflammatory bowel disease]. ⁶¹	Frenzer A...Hammer B	8701273	1996
17	Prospective study of the effect of resection of the rectum on male sexual function. ⁶¹	Fazio VW...Montague D	7190753	1980
18	Liver copper content in patients with inflammatory bowel disease and associated liver disorders. ⁶¹	Ritland S...Steinnes E	531503	1979

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Genes for Inflammatory Bowel Disease 9

Genes related to Inflammatory Bowel Disease 9 (1 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	IBD9	Inflammatory Bowel Disease 9	Genetic Locus	58.51	Susceptibility factor ⁵⁶ GeneCards inferred via : Gene name (show sections)
2	TRAIP	TRAF Interacting Protein	Protein Coding	6.32	DISEASES inferred ¹⁵
3	IL12B	Interleukin 12B	Protein Coding	5.86	DISEASES inferred ¹⁵
4	PLA2G4F	Phospholipase A2 Group IVF	Protein Coding	5.64	DISEASES inferred ¹⁵
5	NOD2	Nucleotide Binding Oligomerization Domain Containing 2	Protein Coding	5.58	DISEASES inferred ¹⁵
6	PLA2G4E	Phospholipase A2 Group IVE	Protein Coding	5.34	DISEASES inferred ¹⁵
7	DNAJC17	DnaJ Heat Shock Protein Family (Hsp40) Member C17	Protein Coding	5.33	DISEASES inferred ¹⁵
8	PLA2G4B	Phospholipase A2 Group IVB	Protein Coding	5.32	DISEASES inferred ¹⁵
9	MST1	Macrophage Stimulating 1	Protein Coding	5.3	DISEASES inferred ¹⁵
10	P4HA2	Prolyl 4-Hydroxylase Subunit Alpha 2	Protein Coding	5.23	DISEASES inferred ¹⁵

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Variations for Inflammatory Bowel Disease 9

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Expression for Inflammatory Bowel Disease 9

Search GEO for disease gene expression data for Inflammatory Bowel Disease 9.

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Pathways for Inflammatory Bowel Disease 9

Pathways related to Inflammatory Bowel Disease 9 according to GeneCards Suite gene sharing:

(show all 14)

#	Super pathways	Score	Top Affiliating Genes
1	Development Endothelin-1/EDNRA signaling ²² Show member pathways Cytoskeleton remodeling FAK signaling ²² Development Endothelin-1/EDNRA transactivation of EGFR ²² GnRH signaling pathway ³⁶ Inflammatory mediator regulation of TRP channels ³⁶	12.29	PLA2G4F PLA2G4E PLA2G4B
2	Immune response Fc epsilon RI pathway ²² Show member pathways Fc epsilon RI signaling pathway ³⁶ Fc-epsilon receptor I signaling in mast cells ¹ Immune response BCR pathway ²² VEGF signaling pathway ³⁶	12.24	PLA2G4F PLA2G4E PLA2G4B
3	Oxytocin signaling pathway ³⁶ Show member pathways Vascular smooth muscle contraction ³⁶	12.11	PLA2G4F PLA2G4E PLA2G4B
4	Phospholipase D signaling pathway ³⁶ Show member pathways Choline metabolism in cancer ³⁶	12.02	PLA2G4F PLA2G4E PLA2G4B
5	Necroptosis ³⁶ Show member pathways Nanoparticle triggered regulated necrosis ¹	11.85	PLA2G4F PLA2G4E PLA2G4B
6	Acyl chain remodelling of PE ⁶⁵ Show member pathways Acyl chain remodelling of PC ⁶⁵ Acyl chain remodelling of PS ⁶⁵ Ether lipid metabolism ³⁶ Synthesis of PA ⁶⁵	11.78	PLA2G4F PLA2G4E PLA2G4B
7	Platelet activation ³⁶	11.64	PLA2G4F PLA2G4E PLA2G4B
8	Linoleic acid metabolism ³⁶ Show member pathways alpha-Linolenic acid metabolism ³⁶ Arachidonic acid metabolism ³⁶	11.57	PLA2G4F PLA2G4E PLA2G4B
9	Serotonergic synapse ³⁶	11.49	PLA2G4F PLA2G4E PLA2G4B
10	Fc gamma R-mediated phagocytosis ³⁶	11.3	PLA2G4F PLA2G4E PLA2G4B
11	phospholipases ¹ Show member pathways Anandamide biosynthesis and metabolism ²²	11.21	PLA2G4F PLA2G4E
12	MSP-RON Signaling ⁶³	11.18	MST1 IL12B
13	Long-term depression ³⁶	10.91	PLA2G4F PLA2G4E PLA2G4B
14	Ovarian steroidogenesis ³⁶	10.49	PLA2G4F PLA2G4E PLA2G4B

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GO Terms for Inflammatory Bowel Disease 9

Biological processes related to Inflammatory Bowel Disease 9 according to GeneCards Suite gene sharing:

(show all 14)

#	Name	GO ID	Score	Top Affiliating Genes
1	lipid catabolic process	GO:0016042	9.61	PLA2G4F PLA2G4E PLA2G4B
2	cellular response to organic cyclic compound	GO:0071407	9.54	PLA2G4F NOD2
3	phospholipid metabolic process	GO:0006644	9.54	PLA2G4F PLA2G4E PLA2G4B
4	positive regulation of NIK/NF-kappaB signaling	GO:1901224	9.52	NOD2 IL12B
5	positive regulation of tumor necrosis factor production	GO:0032760	9.51	NOD2 IL12B
6	phosphatidylcholine acyl-chain remodeling	GO:0036151	9.5	PLA2G4F PLA2G4E PLA2G4B
7	positive regulation of interleukin-10 production	GO:0032733	9.49	NOD2 IL12B
8	phosphatidylinositol acyl-chain remodeling	GO:0036149	9.48	PLA2G4F PLA2G4E
9	phosphatidylglycerol acyl-chain remodeling	GO:0036148	9.46	PLA2G4F PLA2G4B
10	phosphatidylethanolamine acyl-chain remodeling	GO:0036152	9.43	PLA2G4F PLA2G4E PLA2G4B
11	positive regulation of interleukin-17 production	GO:0032740	9.4	NOD2 IL12B
12	phosphatidylserine acyl-chain remodeling	GO:0036150	9.33	PLA2G4F PLA2G4E PLA2G4B
13	phospholipid catabolic process	GO:0009395	9.13	PLA2G4F PLA2G4E PLA2G4B
14	glycerophospholipid catabolic process	GO:0046475	8.8	PLA2G4F PLA2G4E PLA2G4B

Molecular functions related to Inflammatory Bowel Disease 9 according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	calcium-dependent phospholipid binding	GO:0005544	9.5	PLA2G4F PLA2G4E PLA2G4B
2	phospholipase A2 activity	GO:0004623	9.43	PLA2G4F PLA2G4E PLA2G4B
3	lysophospholipase activity	GO:0004622	9.37	PLA2G4F PLA2G4B
4	phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)	GO:0102568	9.33	PLA2G4F PLA2G4E PLA2G4B
5	phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)	GO:0102567	9.13	PLA2G4F PLA2G4E PLA2G4B
6	calcium-dependent phospholipase A2 activity	GO:0047498	8.8	PLA2G4F PLA2G4E PLA2G4B

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Sources for Inflammatory Bowel Disease 9

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NIH Rare Diseases

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia

Inflammatory Bowel Disease 9 (IBD9)

Aliases & Classifications for Inflammatory Bowel Disease 9

MalaCards integrated aliases for Inflammatory Bowel Disease 9:

Classifications:

External Ids:

Summaries for Inflammatory Bowel Disease 9

Related Diseases for Inflammatory Bowel Disease 9

Diseases in the Inflammatory Bowel Disease family:

Diseases related to Inflammatory Bowel Disease 9 via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to Inflammatory Bowel Disease 9:

Symptoms & Phenotypes for Inflammatory Bowel Disease 9

Clinical features from OMIM:

Drugs & Therapeutics for Inflammatory Bowel Disease 9

Drugs for Inflammatory Bowel Disease 9 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Genetic Tests for Inflammatory Bowel Disease 9

Anatomical Context for Inflammatory Bowel Disease 9

MalaCards organs/tissues related to Inflammatory Bowel Disease 9:

Publications for Inflammatory Bowel Disease 9

Articles related to Inflammatory Bowel Disease 9:

Genes for Inflammatory Bowel Disease 9

Genes related to Inflammatory Bowel Disease 9 (1 elite genes):

Variations for Inflammatory Bowel Disease 9

Expression for Inflammatory Bowel Disease 9

Pathways for Inflammatory Bowel Disease 9

Pathways related to Inflammatory Bowel Disease 9 according to GeneCards Suite gene sharing:

GO Terms for Inflammatory Bowel Disease 9

Biological processes related to Inflammatory Bowel Disease 9 according to GeneCards Suite gene sharing:

Molecular functions related to Inflammatory Bowel Disease 9 according to GeneCards Suite gene sharing:

Sources for Inflammatory Bowel Disease 9