IBD9
MCID: INF092
MIFTS: 38

Inflammatory Bowel Disease 9 (IBD9)

Categories: Blood diseases, Bone diseases, Gastrointestinal diseases, Genetic diseases, Immune diseases, Rare diseases

Aliases & Classifications for Inflammatory Bowel Disease 9

MalaCards integrated aliases for Inflammatory Bowel Disease 9:

Name: Inflammatory Bowel Disease 9 57 12 13 15 72
Ibd9 57 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0110886
UMLS 72 C1838019

Summaries for Inflammatory Bowel Disease 9

Disease Ontology : 12 An inflammatory bowel disease that has material basis in variation in the chromosome region 3p26.

MalaCards based summary : Inflammatory Bowel Disease 9, also known as ibd9, is related to colitis and inflammatory bowel disease. An important gene associated with Inflammatory Bowel Disease 9 is IBD9 (Inflammatory Bowel Disease 9), and among its related pathways/superpathways are Innate Immune System and Activated TLR4 signalling. The drugs Antibodies and Immunoglobulins have been mentioned in the context of this disorder. Affiliated tissues include liver, and related phenotypes are hematopoietic system and digestive/alimentary

More information from OMIM: 608448 PS266600

Related Diseases for Inflammatory Bowel Disease 9

Diseases in the Inflammatory Bowel Disease family:

Inflammatory Bowel Disease 11 Inflammatory Bowel Disease 1
Inflammatory Bowel Disease 2 Inflammatory Bowel Disease 3
Inflammatory Bowel Disease 7 Inflammatory Bowel Disease 5
Inflammatory Bowel Disease 8 Inflammatory Bowel Disease 6
Inflammatory Bowel Disease 4 Inflammatory Bowel Disease 9
Inflammatory Bowel Disease 10 Inflammatory Bowel Disease 12
Inflammatory Bowel Disease 13 Inflammatory Bowel Disease 14
Inflammatory Bowel Disease 15 Inflammatory Bowel Disease 16
Inflammatory Bowel Disease 17 Inflammatory Bowel Disease 18
Inflammatory Bowel Disease 19 Inflammatory Bowel Disease 20
Inflammatory Bowel Disease 21 Inflammatory Bowel Disease 22
Inflammatory Bowel Disease 23 Inflammatory Bowel Disease 24
Inflammatory Bowel Disease 25, Autosomal Recessive Inflammatory Bowel Disease 26
Inflammatory Bowel Disease 27 Inflammatory Bowel Disease 28, Autosomal Recessive
Inflammatory Bowel Disease 29 Inflammatory Bowel Disease 28
Inflammatory Bowel Disease 25 Rare Inflammatory Bowel Disease

Diseases related to Inflammatory Bowel Disease 9 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 61)
# Related Disease Score Top Affiliating Genes
1 colitis 28.6 TLR9 TLR4 NOD2 MLH1
2 inflammatory bowel disease 27.9 TLR5 TLR4 TLR2 NOD2 NOD1 IL18
3 lymphoproliferative syndrome, x-linked, 2 10.5 NOD2 NOD1
4 sapho syndrome 10.2 NOD2 IL18
5 superficial basal cell carcinoma 10.1 TLR9 TLR8 TLR7
6 neurosyphilis 10.0 TLR6 TLR2 TLR1
7 mucocutaneous leishmaniasis 10.0 TLR9 TLR3
8 juvenile nasopharyngeal angiofibroma 10.0 TLR9 TLR7 TLR3
9 lyme disease 10.0 TLR6 TLR2 TLR1
10 pouchitis 9.9 TLR4 NOD2
11 ocular toxoplasmosis 9.9 TLR9 TLR5 TLR1 NOD2
12 urethritis 9.9 TLR6 TLR1
13 colonic disease 9.9 TLR9 NOD2 MLH1
14 variola major 9.9 TLR4 TLR3
15 viral infectious disease 9.8 TLR9 TLR8 TLR7 TLR3
16 genital herpes 9.7 TLR9 TLR2 IL18
17 lymphadenitis 9.7 TLR4 NOD2 IL18
18 prosthetic joint infection 9.7 TLR4 TLR2
19 inflammatory bowel disease 3 9.6 NOD2 NOD1 IL18 IL11 CCL20
20 bronchiolitis 9.6 TLR9 TLR4 TLR10
21 trench fever 9.6 TLR4 TLR2
22 pulmonary tuberculosis 9.6 TLR9 TLR2 IL18
23 spondylarthropathy 9.5 TLR4 TLR2 NOD2
24 fungal keratitis 9.5 TLR4 TLR2
25 oral cavity cancer 9.5 TLR9 TLR6 TLR2 IL18
26 legionellosis 9.4 TLR5 TLR4 TLR2
27 mouth disease 9.4 TLR9 TLR4 TLR3
28 asthma 9.4 TLR9 TLR6 NOD1 IL18 IL11
29 aspergillosis 9.4 TLR9 TLR4 TLR2
30 acute cervicitis 9.4 TLR4 TLR2
31 toxoplasmosis 9.4 TLR9 TLR4 TLR2
32 myositis fibrosa 9.3 TLR9 TLR4 TLR2
33 middle ear disease 9.3 TLR9 TLR4 TLR2
34 immune system disease 9.3 TLR9 TLR6 TLR5 TLR3 TLR10 TLR1
35 keratitis, hereditary 9.3 TLR9 TLR4 TLR2
36 primary bacterial infectious disease 9.3 TLR9 TLR4 TLR2
37 cutaneous leishmaniasis 9.3 TLR9 TLR4 TLR2
38 behcet syndrome 9.3 TLR9 TLR4 NOD2 IL18
39 leishmaniasis 9.3 TLR9 TLR4 TLR2
40 visceral leishmaniasis 9.3 TLR9 TLR4 TLR2
41 proteasome-associated autoinflammatory syndrome 1 9.3 TLR4 TLR2 IL18
42 penicilliosis 9.3 TLR6 TLR4 TLR2 TLR1
43 ileitis 9.3 TLR5 TLR4 TLR2 NOD2
44 pelvic inflammatory disease 9.3 TLR6 TLR4 TLR2 TLR1
45 intestinal disease 9.2 TLR9 TLR4 NOD2 MLH1
46 periodontitis 9.2 TLR9 TLR4 TLR2
47 gastrointestinal system disease 9.2 TLR9 TLR4 NOD2 MLH1
48 ulcerative colitis 9.2 TLR4 NOD2 MLH1
49 suppurative otitis media 9.1 TLR9 TLR5 TLR4 TLR2
50 q fever 9.1 TLR4 TLR2 TLR10 TLR1 NOD2

Graphical network of the top 20 diseases related to Inflammatory Bowel Disease 9:



Diseases related to Inflammatory Bowel Disease 9

Symptoms & Phenotypes for Inflammatory Bowel Disease 9

Clinical features from OMIM:

608448

MGI Mouse Phenotypes related to Inflammatory Bowel Disease 9:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10 BDKRB2 IL18 MLH1 NOD1 NOD2 TLR1
2 digestive/alimentary MP:0005381 9.86 BDKRB2 IL18 MLH1 NOD2 TLR2 TLR4
3 homeostasis/metabolism MP:0005376 9.7 BDKRB2 IL18 MLH1 NOD2 TLR2 TLR3
4 immune system MP:0005387 9.47 BDKRB2 IL18 MLH1 NOD1 NOD2 TLR1

Drugs & Therapeutics for Inflammatory Bowel Disease 9

Drugs for Inflammatory Bowel Disease 9 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antibodies
2 Immunoglobulins

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Quantification of GADD34 Expression in Rheumatoid Arthritis Completed NCT02401165

Search NIH Clinical Center for Inflammatory Bowel Disease 9

Genetic Tests for Inflammatory Bowel Disease 9

Anatomical Context for Inflammatory Bowel Disease 9

MalaCards organs/tissues related to Inflammatory Bowel Disease 9:

41
Liver

Publications for Inflammatory Bowel Disease 9

Articles related to Inflammatory Bowel Disease 9:

(show all 16)
# Title Authors PMID Year
1
Evidence for an inflammatory bowel disease locus on chromosome 3p26: linkage, transmission/disequilibrium and partitioning of linkage. 8
12354785 2002
2
Fine mapping of the chromosome 3p susceptibility locus in inflammatory bowel disease. 8
11156639 2001
3
Two stage genome-wide search in inflammatory bowel disease provides evidence for susceptibility loci on chromosomes 3, 7 and 12. 8
8841195 1996
4
The diagnostic performance of (99m)Tc-HMPAO radiolabeled leucocytes scintigraphy in the investigations of infection. A single center experience. 38
26665208 2015
5
Predicting inadequate bowel preparation for colonoscopy in participants receiving split-dose bowel preparation: development and validation of a prediction score. 38
25600879 2015
6
Reduction of CD68+ macrophages and decreased IL-17 expression in intestinal mucosa of patients with inflammatory bowel disease strongly correlate with endoscopic response and mucosal healing following infliximab therapy. 38
23448791 2013
7
Infliximab safety profile and long-term applicability in inflammatory bowel disease: 9-year experience in clinical practice. 38
20002026 2010
8
Evaluation of the MLH1 I219V alteration in DNA mismatch repair activity and ulcerative colitis. 38
18200512 2008
9
Immune system alterations in patients with inflammatory bowel disease during remission. 38
18277086 2008
10
Novel genetic markers in inflammatory bowel disease. 38
17948929 2007
11
Clinical utility of wireless capsule endoscopy: experience with 200 cases. 38
16394875 2006
12
Association of cystic fibrosis with abnormalities in fatty acid metabolism. 38
14762183 2004
13
Autoimmunity in Wiskott-Aldrich syndrome: risk factors, clinical features, and outcome in a single-center cohort of 55 patients. 38
12728121 2003
14
[Social consequences and quality of life in patients with chronic inflammatory bowel disease]. 38
8701273 1996
15
Prospective study of the effect of resection of the rectum on male sexual function. 38
7190753 1980
16
Liver copper content in patients with inflammatory bowel disease and associated liver disorders. 38
531503 1979

Variations for Inflammatory Bowel Disease 9

Expression for Inflammatory Bowel Disease 9

Search GEO for disease gene expression data for Inflammatory Bowel Disease 9.

Pathways for Inflammatory Bowel Disease 9

Pathways related to Inflammatory Bowel Disease 9 according to GeneCards Suite gene sharing:

(show all 27)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.02 TLR9 TLR8 TLR7 TLR6 TLR5 TLR4
2
Show member pathways
13.62 TLR9 TLR8 TLR7 TLR6 TLR5 TLR4
3
Show member pathways
13.47 TLR9 TLR8 TLR7 TLR6 TLR5 TLR4
4
Show member pathways
13.26 TLR9 TLR8 TLR7 TLR6 TLR5 TLR4
5
Show member pathways
12.8 TLR9 TLR8 TLR7 TLR6 TLR5 TLR4
6
Show member pathways
12.73 TLR9 TLR8 TLR7 TLR6 TLR5 TLR4
7 12.65 TLR9 TLR8 TLR7 TLR6 TLR3 TLR2
8
Show member pathways
12.55 TLR5 TLR4 TLR2 NOD2 IL18
9
Show member pathways
12.5 TLR9 TLR8 TLR7 TLR6 TLR5 TLR4
10
Show member pathways
12.4 TLR9 TLR8 TLR7 TLR6 TLR5 TLR4
11
Show member pathways
12.38 TLR6 TLR4 TLR2 TLR1
12 12.32 TLR9 TLR6 TLR4 TLR2 TLR1 NOD2
13
Show member pathways
12.3 TLR9 TLR8 TLR7 TLR6 TLR5 TLR4
14
Show member pathways
12.3 TLR9 TLR8 TLR7 TLR6 TLR5 TLR4
15
Show member pathways
12.17 TLR9 TLR8 TLR7 TLR6 TLR5 TLR4
16
Show member pathways
12.16 TLR9 TLR8 TLR7 TLR6 TLR5 TLR4
17 12.03 TLR9 TLR8 TLR7 TLR6 TLR5 TLR4
18
Show member pathways
12.01 TLR6 TLR4 TLR2 TLR1
19
Show member pathways
12.01 TLR9 TLR8 TLR7 TLR6 TLR5 TLR4
20 11.94 TLR4 TLR2 IL18 IL11 CCL20
21 11.91 TLR9 TLR8 TLR7 TLR6 TLR5 TLR4
22 11.72 TLR5 TLR4 IL18
23 11.64 TLR5 TLR4 TLR2 IL18
24 11.58 TLR9 TLR4 TLR2 IL18
25 11.48 TLR4 TLR2 IL18
26 11.41 NOD2 NOD1 IL18
27 11.17 TLR2 TLR1 IL18

GO Terms for Inflammatory Bowel Disease 9

Cellular components related to Inflammatory Bowel Disease 9 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.95 TLR6 TLR4 TLR3 TLR2 TLR10 TLR1
2 cytoplasmic vesicle GO:0031410 9.88 TLR9 TLR7 TLR6 TLR2 TLR1
3 endosome GO:0005768 9.83 TLR9 TLR7 TLR4 TLR3 BDKRB2
4 phagocytic vesicle membrane GO:0030670 9.54 TLR6 TLR2 TLR1
5 endosome membrane GO:0010008 9.35 TLR9 TLR8 TLR7 TLR4 TLR3
6 early phagosome GO:0032009 9.26 TLR9 TLR7
7 Toll-like receptor 1-Toll-like receptor 2 protein complex GO:0035354 9.16 TLR2 TLR1
8 endolysosome membrane GO:0036020 8.92 TLR9 TLR8 TLR7 TLR3
9 membrane GO:0016020 10.3 TLR9 TLR8 TLR7 TLR6 TLR5 TLR4
10 plasma membrane GO:0005886 10.1 TLR9 TLR8 TLR7 TLR6 TLR5 TLR4

Biological processes related to Inflammatory Bowel Disease 9 according to GeneCards Suite gene sharing:

(show top 50) (show all 86)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of chemokine production GO:0032722 9.98 TLR9 TLR7 TLR4 TLR3 TLR2
2 cellular response to interferon-gamma GO:0071346 9.97 TLR4 TLR3 TLR2 CCL20
3 microglial cell activation GO:0001774 9.97 TLR8 TLR7 TLR6 TLR3 TLR2
4 positive regulation of interferon-beta production GO:0032728 9.95 TLR9 TLR4 TLR3 TLR2
5 positive regulation of interleukin-8 production GO:0032757 9.95 TLR9 TLR7 TLR5 TLR4 TLR3 TLR2
6 activation of MAPK activity GO:0000187 9.94 TLR4 NOD2 NOD1
7 positive regulation of interleukin-12 production GO:0032735 9.94 TLR9 TLR4 TLR3 TLR2
8 positive regulation of interleukin-10 production GO:0032733 9.93 TLR9 TLR4 TLR2 NOD2
9 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.92 TLR9 TLR4 TLR2 NOD2
10 I-kappaB phosphorylation GO:0007252 9.92 TLR9 TLR7 TLR4 TLR3 TLR2
11 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.92 TLR9 TLR7 TLR4 TLR3 TLR2 NOD2
12 positive regulation of interferon-gamma biosynthetic process GO:0045078 9.91 TLR9 TLR8 TLR7 TLR3
13 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.91 TLR9 TLR8 TLR7 TLR4
14 regulation of cytokine secretion GO:0050707 9.91 TLR9 TLR8 TLR6 TLR5 TLR2 TLR10
15 positive regulation of nitric oxide biosynthetic process GO:0045429 9.89 TLR6 TLR5 TLR4
16 positive regulation of interferon-beta biosynthetic process GO:0045359 9.88 TLR9 TLR8 TLR7 TLR4 TLR3
17 lipopolysaccharide-mediated signaling pathway GO:0031663 9.87 TLR4 TLR2 IL18
18 positive regulation of interleukin-1 beta secretion GO:0050718 9.87 TLR8 TLR4 NOD2
19 positive regulation of toll-like receptor signaling pathway GO:0034123 9.87 TLR9 TLR5 TLR3 TLR2
20 positive regulation of interferon-alpha biosynthetic process GO:0045356 9.86 TLR9 TLR8 TLR7 TLR3
21 positive regulation of interleukin-6 production GO:0032755 9.86 TLR9 TLR8 TLR7 TLR4 TLR3 TLR2
22 TRIF-dependent toll-like receptor signaling pathway GO:0035666 9.85 TLR6 TLR4 TLR3
23 positive regulation of stress-activated MAPK cascade GO:0032874 9.85 TLR4 NOD2 NOD1
24 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.84 TLR6 TLR4 NOD2
25 toll-like receptor 9 signaling pathway GO:0034162 9.83 TLR9 TLR8 TLR7
26 cell activation GO:0001775 9.83 TLR6 TLR2 TLR1
27 toll-like receptor signaling pathway GO:0002224 9.81 TLR9 TLR8 TLR7 TLR6 TLR4 TLR3
28 nucleotide-binding oligomerization domain containing signaling pathway GO:0070423 9.76 NOD2 NOD1
29 necroptotic process GO:0070266 9.76 TLR4 TLR3
30 activation of NF-kappaB-inducing kinase activity GO:0007250 9.76 TLR6 TLR3
31 positive regulation of macrophage activation GO:0043032 9.76 TLR6 TLR4
32 positive regulation of interleukin-8 secretion GO:2000484 9.76 TLR2 TLR1
33 positive regulation of reactive oxygen species biosynthetic process GO:1903428 9.76 TLR6 TLR4
34 maintenance of gastrointestinal epithelium GO:0030277 9.76 TLR9 NOD2
35 positive regulation of interleukin-17 production GO:0032740 9.75 NOD2 IL18
36 response to molecule of bacterial origin GO:0002237 9.75 TLR9 TLR2
37 positive regulation of tumor necrosis factor biosynthetic process GO:0042535 9.75 TLR4 TLR1
38 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.75 TLR9 IL18
39 MyD88-independent toll-like receptor signaling pathway GO:0002756 9.75 TLR4 TLR3
40 macrophage activation GO:0042116 9.75 TLR4 TLR1
41 T-helper 1 type immune response GO:0042088 9.74 TLR4 IL18
42 positive regulation of interleukin-1 beta production GO:0032731 9.74 NOD2 NOD1
43 cellular response to lipoteichoic acid GO:0071223 9.74 TLR4 TLR2
44 detection of bacterium GO:0016045 9.74 NOD2 NOD1
45 cellular response to muramyl dipeptide GO:0071225 9.74 NOD2 NOD1
46 interleukin-1 beta secretion GO:0050702 9.74 TLR6 TLR4
47 cellular response to oxidised low-density lipoprotein particle stimulus GO:0140052 9.73 TLR6 TLR4
48 positive regulation of NLRP3 inflammasome complex assembly GO:1900227 9.73 TLR6 TLR4
49 positive regulation of interleukin-6 biosynthetic process GO:0045410 9.73 TLR6 TLR1
50 positive regulation of dendritic cell antigen processing and presentation GO:0002606 9.73 NOD2 NOD1

Molecular functions related to Inflammatory Bowel Disease 9 according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.95 TLR6 TLR4 TLR3 TLR2 TLR10 TLR1
2 protein heterodimerization activity GO:0046982 9.88 TLR6 TLR4 TLR2 TLR1 BDKRB2
3 double-stranded RNA binding GO:0003725 9.63 TLR8 TLR7 TLR3
4 signaling receptor activity GO:0038023 9.63 TLR8 TLR6 TLR4 TLR3 TLR2 TLR1
5 CARD domain binding GO:0050700 9.52 NOD2 NOD1
6 interleukin-1 receptor binding GO:0005149 9.51 TLR9 TLR5
7 peptidoglycan binding GO:0042834 9.5 TLR2 NOD2 NOD1
8 siRNA binding GO:0035197 9.49 TLR9 TLR7
9 lipopolysaccharide receptor activity GO:0001875 9.43 TLR4 TLR2
10 lipopeptide binding GO:0071723 9.43 TLR6 TLR2 TLR1
11 Toll-like receptor 2 binding GO:0035663 9.37 TLR6 TLR1
12 transmembrane signaling receptor activity GO:0004888 9.28 TLR9 TLR8 TLR7 TLR6 TLR5 TLR4
13 signaling pattern recognition receptor activity GO:0008329 9.26 TLR9 TLR8 TLR7 TLR2

Sources for Inflammatory Bowel Disease 9

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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