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IBD9
MCID: INF092
MIFTS: 32

Inflammatory Bowel Disease 9 (IBD9)

Categories: Blood diseases, Bone diseases, Gastrointestinal diseases, Genetic diseases, Immune diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for Inflammatory Bowel Disease 9

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MalaCards integrated aliases for Inflammatory Bowel Disease 9:

Name: Inflammatory Bowel Disease 9 57 12 13 15 73
Ibd9 57 12

Classifications:

MalaCards categories:
Global: Genetic diseases Rare diseases
Anatomical: Gastrointestinal diseases Bone diseases Blood diseases Immune diseases
See all MalaCards categories (disease lists)


External Ids:

OMIM 57 608448
Disease Ontology 12 DOID:0110886
UMLS 73 C1838019
Sources

Summaries for Inflammatory Bowel Disease 9

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Disease Ontology : 12 An inflammatory bowel disease that has material basis in variation in the chromosome region 3p26.

MalaCards based summary : Inflammatory Bowel Disease 9, also known as ibd9, is related to inflammatory bowel disease and perrault syndrome 1. An important gene associated with Inflammatory Bowel Disease 9 is IBD9 (Inflammatory Bowel Disease 9), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Immune response IFN gamma signaling pathway. Affiliated tissues include bone and colon, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Description from OMIM: 608448
Sources

Related Diseases for Inflammatory Bowel Disease 9

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Diseases in the Inflammatory Bowel Disease family:

Inflammatory Bowel Disease 11 Inflammatory Bowel Disease 1
Inflammatory Bowel Disease 2 Inflammatory Bowel Disease 3
Inflammatory Bowel Disease 7 Inflammatory Bowel Disease 5
Inflammatory Bowel Disease 8 Inflammatory Bowel Disease 6
Inflammatory Bowel Disease 4 Inflammatory Bowel Disease 9
Inflammatory Bowel Disease 10 Inflammatory Bowel Disease 12
Inflammatory Bowel Disease 13 Inflammatory Bowel Disease 14
Inflammatory Bowel Disease 15 Inflammatory Bowel Disease 16
Inflammatory Bowel Disease 17 Inflammatory Bowel Disease 18
Inflammatory Bowel Disease 19 Inflammatory Bowel Disease 20
Inflammatory Bowel Disease 21 Inflammatory Bowel Disease 22
Inflammatory Bowel Disease 23 Inflammatory Bowel Disease 24
Inflammatory Bowel Disease 25, Autosomal Recessive Inflammatory Bowel Disease 26
Inflammatory Bowel Disease 27 Inflammatory Bowel Disease 28, Autosomal Recessive
Inflammatory Bowel Disease 29 Inflammatory Bowel Disease 28
Inflammatory Bowel Disease 25

Diseases related to Inflammatory Bowel Disease 9 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 17)
# Related Disease Score Top Affiliating Genes
1 inflammatory bowel disease 31.0 CCL20 IBD9 IL11 IL18 NOD1 NOD2
2 perrault syndrome 1 11.1
3 lymphoproliferative syndrome, x-linked, 2 10.0 NOD1 NOD2
4 inflammatory bowel disease 1 10.0 NOD1 NOD2
5 blau syndrome 10.0 NOD1 NOD2
6 sapho syndrome 10.0 IL18 NOD2
7 listeria meningitis 10.0 CCL20 IL18
8 thrombocytopenic purpura, autoimmune 10.0 IL11 IL18
9 acute graft versus host disease 9.9 IL18 NOD2
10 lymphadenitis 9.9 IL18 NOD2
11 colonic disease 9.8 MLH1 NOD2
12 sarcoidosis 1 9.8 IL18 NOD2
13 bacterial infectious disease 9.8 IL18 NOD1 NOD2
14 intestinal disease 9.8 MLH1 NOD2
15 rheumatoid arthritis 9.7 CCL20 IL11 IL18
16 gastrointestinal system disease 9.7 MLH1 NOD2
17 inflammatory bowel disease 3 9.5 CCL20 IL11 IL18 NOD1 NOD2

Graphical network of the top 20 diseases related to Inflammatory Bowel Disease 9:



Diseases related to Inflammatory Bowel Disease 9
Sources

Symptoms & Phenotypes for Inflammatory Bowel Disease 9

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Clinical features from OMIM:

608448

GenomeRNAi Phenotypes related to Inflammatory Bowel Disease 9 according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.53 IL18 MLH1 NOD1 NOD2
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.53 IL18 MLH1 NOD1 NOD2
Sources

Drugs & Therapeutics for Inflammatory Bowel Disease 9

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Search Clinical Trials , NIH Clinical Center for Inflammatory Bowel Disease 9

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Genetic Tests for Inflammatory Bowel Disease 9

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Anatomical Context for Inflammatory Bowel Disease 9

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MalaCards organs/tissues related to Inflammatory Bowel Disease 9:

41
Bone, Colon
Sources

Publications for Inflammatory Bowel Disease 9

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Articles related to Inflammatory Bowel Disease 9:

# Title Authors Year
1
Infliximab safety profile and long-term applicability in inflammatory bowel disease: 9-year experience in clinical practice. ( 20002026 )
2010
Sources

Variations for Inflammatory Bowel Disease 9

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Expression for Inflammatory Bowel Disease 9

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Search GEO for disease gene expression data for Inflammatory Bowel Disease 9.
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Pathways for Inflammatory Bowel Disease 9

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Pathways related to Inflammatory Bowel Disease 9 according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Cytokine Signaling in Immune system 66
Show member pathways
 12.66 CCL20 IL11 IL18 NOD1 NOD2
2
Immune response IFN gamma signaling pathway 22
Show member pathways
 11.59 CCL20 IL11 IL18
3
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 66
Show member pathways
 11.57 NOD1 NOD2
4
TNF signaling pathway 37
11.54 CCL20 NOD2
5
Microglia Activation During Neuroinflammation: Microglia Polarization 65
11.31 CCL20 IL18
6
Shigellosis 37
11.25 NOD1 NOD2
7
Rheumatoid arthritis 37
11.09 CCL20 IL11 IL18
8
Interleukin-10 signaling 66
11.06 CCL20 IL18
9
Ovarian tumor domain proteases 66
10.89 NOD1 NOD2
10
G-protein signaling_RhoB regulation pathway 22
10.66 CCL20 IL11 IL18
11
G-protein signaling_Rap2B regulation pathway 22
10.56 CCL20 IL11 IL18
12
Nucleotide-binding Oligomerization Domain (NOD) pathway 1
10.41 IL18 NOD1 NOD2
Sources

GO Terms for Inflammatory Bowel Disease 9

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Biological processes related to Inflammatory Bowel Disease 9 according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.77 CCL20 IL11 IL18
2 inflammatory response GO:0006954 9.74 CCL20 IL18 NOD1
3 cytokine-mediated signaling pathway GO:0019221 9.7 CCL20 IL11 IL18
4 defense response to bacterium GO:0042742 9.69 CCL20 NOD1 NOD2
5 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.67 CCL20 NOD1 NOD2
6 positive regulation of JNK cascade GO:0046330 9.61 NOD1 NOD2
7 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.61 IL18 NOD1 NOD2
8 protein complex oligomerization GO:0051259 9.6 NOD1 NOD2
9 cellular response to organic cyclic compound GO:0071407 9.58 IL18 NOD2
10 positive regulation of interleukin-6 production GO:0032755 9.58 NOD1 NOD2
11 positive regulation of tumor necrosis factor production GO:0032760 9.56 NOD1 NOD2
12 JNK cascade GO:0007254 9.55 NOD1 NOD2
13 interleukin-1-mediated signaling pathway GO:0070498 9.54 NOD1 NOD2
14 nucleotide-binding oligomerization domain containing signaling pathway GO:0070423 9.48 NOD1 NOD2
15 positive regulation of stress-activated MAPK cascade GO:0032874 9.46 NOD1 NOD2
16 positive regulation of interleukin-17 production GO:0032740 9.4 IL18 NOD2
17 positive regulation of interleukin-1 beta production GO:0032731 9.37 NOD1 NOD2
18 cellular response to muramyl dipeptide GO:0071225 9.32 NOD1 NOD2
19 detection of bacterium GO:0016045 9.26 NOD1 NOD2
20 positive regulation of dendritic cell antigen processing and presentation GO:0002606 9.16 NOD1 NOD2
21 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.13 IL18 NOD1 NOD2
22 detection of biotic stimulus GO:0009595 8.62 NOD1 NOD2

Molecular functions related to Inflammatory Bowel Disease 9 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.33 CCL20 IL11 IL18
2 peptidoglycan binding GO:0042834 8.96 NOD1 NOD2
3 CARD domain binding GO:0050700 8.62 NOD1 NOD2
Sources

Sources for Inflammatory Bowel Disease 9

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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