MCID: INF092
MIFTS: 26

Inflammatory Bowel Disease 9

Categories: Gastrointestinal diseases, Genetic diseases, Rare diseases, Bone diseases, Blood diseases, Immune diseases

Aliases & Classifications for Inflammatory Bowel Disease 9

MalaCards integrated aliases for Inflammatory Bowel Disease 9:

Name: Inflammatory Bowel Disease 9 57 12 13 15 73
Ibd9 57 12

Classifications:



External Ids:

OMIM 57 608448
Disease Ontology 12 DOID:0110886
UMLS 73 C1838019

Summaries for Inflammatory Bowel Disease 9

Disease Ontology : 12 An inflammatory bowel disease that has material basis in variation in the chromosome region 3p26.

MalaCards based summary : Inflammatory Bowel Disease 9, also known as ibd9, is related to inflammatory bowel disease and lymphoproliferative syndrome, x-linked, 2. An important gene associated with Inflammatory Bowel Disease 9 is IBD9 (Inflammatory Bowel Disease 9), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Immune response IFN gamma signaling pathway. Related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Description from OMIM: 608448

Related Diseases for Inflammatory Bowel Disease 9

Diseases in the Inflammatory Bowel Disease family:

Inflammatory Bowel Disease 11 Inflammatory Bowel Disease 1
Inflammatory Bowel Disease 2 Inflammatory Bowel Disease 3
Inflammatory Bowel Disease 7 Inflammatory Bowel Disease 5
Inflammatory Bowel Disease 8 Inflammatory Bowel Disease 6
Inflammatory Bowel Disease 4 Inflammatory Bowel Disease 9
Inflammatory Bowel Disease 10 Inflammatory Bowel Disease 12
Inflammatory Bowel Disease 13 Inflammatory Bowel Disease 14
Inflammatory Bowel Disease 15 Inflammatory Bowel Disease 16
Inflammatory Bowel Disease 17 Inflammatory Bowel Disease 18
Inflammatory Bowel Disease 19 Inflammatory Bowel Disease 20
Inflammatory Bowel Disease 21 Inflammatory Bowel Disease 22
Inflammatory Bowel Disease 23 Inflammatory Bowel Disease 24
Inflammatory Bowel Disease 25, Autosomal Recessive Inflammatory Bowel Disease 26
Inflammatory Bowel Disease 27 Inflammatory Bowel Disease 28, Autosomal Recessive
Inflammatory Bowel Disease 28 Inflammatory Bowel Disease 25

Diseases related to Inflammatory Bowel Disease 9 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 11)
# Related Disease Score Top Affiliating Genes
1 inflammatory bowel disease 28.4 CCL20 IBD9 IL11 IL18 NOD1 NOD2
2 lymphoproliferative syndrome, x-linked, 2 10.1 NOD1 NOD2
3 inflammatory bowel disease 1 10.0 NOD1 NOD2
4 blau syndrome 10.0 NOD1 NOD2
5 sapho syndrome 9.8 IL18 NOD2
6 listeria meningitis 9.8 CCL20 IL18
7 acute graft versus host disease 9.7 IL18 NOD2
8 lymphadenitis 9.6 IL18 NOD2
9 sarcoidosis 1 9.5 IL18 NOD2
10 rheumatoid arthritis 8.7 CCL20 IL11 IL18
11 inflammatory bowel disease 3 8.2 CCL20 IL11 IL18 NOD1 NOD2

Graphical network of the top 20 diseases related to Inflammatory Bowel Disease 9:



Diseases related to Inflammatory Bowel Disease 9

Symptoms & Phenotypes for Inflammatory Bowel Disease 9

Clinical features from OMIM:

608448

GenomeRNAi Phenotypes related to Inflammatory Bowel Disease 9 according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.53 NOD1 NOD2 IL18 MLH1
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.53 MLH1 NOD1 NOD2 IL18

Drugs & Therapeutics for Inflammatory Bowel Disease 9

Search Clinical Trials , NIH Clinical Center for Inflammatory Bowel Disease 9

Genetic Tests for Inflammatory Bowel Disease 9

Anatomical Context for Inflammatory Bowel Disease 9

Publications for Inflammatory Bowel Disease 9

Variations for Inflammatory Bowel Disease 9

Expression for Inflammatory Bowel Disease 9

Search GEO for disease gene expression data for Inflammatory Bowel Disease 9.

Pathways for Inflammatory Bowel Disease 9

Pathways related to Inflammatory Bowel Disease 9 according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.66 CCL20 IL11 IL18 NOD1 NOD2
2
Show member pathways
11.56 CCL20 IL11 IL18
3 11.47 CCL20 NOD2
4 11.22 NOD1 NOD2
5 11.09 CCL20 IL11 IL18
6 11.01 CCL20 IL18
7 10.82 NOD1 NOD2
8 10.41 IL18 NOD1 NOD2

GO Terms for Inflammatory Bowel Disease 9

Biological processes related to Inflammatory Bowel Disease 9 according to GeneCards Suite gene sharing:

(show all 29)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.8 CCL20 IL11 IL18
2 cytokine-mediated signaling pathway GO:0019221 9.74 CCL20 IL11 IL18
3 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.71 CCL20 NOD1 NOD2
4 defense response to bacterium GO:0042742 9.69 CCL20 NOD1 NOD2
5 negative regulation of inflammatory response GO:0050728 9.64 NOD1 NOD2
6 interleukin-1-mediated signaling pathway GO:0070498 9.64 NOD1 NOD2
7 negative regulation of NF-kappaB transcription factor activity GO:0032088 9.63 NOD1 NOD2
8 regulation of inflammatory response GO:0050727 9.63 NOD1 NOD2
9 protein complex oligomerization GO:0051259 9.62 NOD1 NOD2
10 inflammatory response GO:0006954 9.62 CCL20 IL18 NOD1 NOD2
11 cellular response to organic cyclic compound GO:0071407 9.61 IL18 NOD2
12 positive regulation of JNK cascade GO:0046330 9.61 NOD1 NOD2
13 JNK cascade GO:0007254 9.6 NOD1 NOD2
14 positive regulation of interleukin-6 production GO:0032755 9.59 NOD1 NOD2
15 regulation of cytokine production GO:0001817 9.58 NOD1 NOD2
16 positive regulation of tumor necrosis factor production GO:0032760 9.58 NOD1 NOD2
17 signaling GO:0023052 9.56 NOD1 NOD2
18 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.55 NOD1 NOD2
19 negative regulation of immune response GO:0050777 9.52 NOD1 NOD2
20 nucleotide-binding oligomerization domain containing signaling pathway GO:0070423 9.49 NOD1 NOD2
21 positive regulation of stress-activated MAPK cascade GO:0032874 9.48 NOD1 NOD2
22 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.46 CCL20 NOD2
23 positive regulation of interleukin-17 production GO:0032740 9.43 IL18 NOD2
24 positive regulation of interleukin-1 beta production GO:0032731 9.4 NOD1 NOD2
25 detection of bacterium GO:0016045 9.37 NOD1 NOD2
26 positive regulation of dendritic cell antigen processing and presentation GO:0002606 9.26 NOD1 NOD2
27 cellular response to muramyl dipeptide GO:0071225 9.16 NOD1 NOD2
28 detection of biotic stimulus GO:0009595 8.96 NOD1 NOD2
29 positive regulation of NIK/NF-kappaB signaling GO:1901224 8.8 IL18 NOD1 NOD2

Molecular functions related to Inflammatory Bowel Disease 9 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.33 CCL20 IL11 IL18
2 peptidoglycan binding GO:0042834 8.96 NOD1 NOD2
3 CARD domain binding GO:0050700 8.62 NOD1 NOD2

Sources for Inflammatory Bowel Disease 9

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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