MCID: INF002
MIFTS: 28

Inflammatory Diarrhea

Categories: Gastrointestinal diseases, Genetic diseases, Oral diseases, Rare diseases

Aliases & Classifications for Inflammatory Diarrhea

MalaCards integrated aliases for Inflammatory Diarrhea:

Name: Inflammatory Diarrhea 12 15 72

Classifications:



External Ids:

Disease Ontology 12 DOID:0050132
UMLS 72 C0521604

Summaries for Inflammatory Diarrhea

Disease Ontology : 12 A gastrointestinal system infectious disease involving diarrhea that occurs when there is damage to the mucosal lining or brush border, which leads to a passive loss of protein-rich fluids, and a decreased ability to absorb these lost fluids. It can be caused by bacterial infections, viral infections, parasitic infections, or autoimmune problems such as inflammatory bowel diseases. It can also be caused by tuberculosis, colon cancer, and enteritis.

MalaCards based summary : Inflammatory Diarrhea is related to diarrhea and dysentery. An important gene associated with Inflammatory Diarrhea is SPI1 (Spi-1 Proto-Oncogene), and among its related pathways/superpathways are Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways and Mineral absorption. Affiliated tissues include colon, testes and neutrophil, and related phenotypes are Decreased OCT4 protein expression and Decreased OCT4 protein expression

Related Diseases for Inflammatory Diarrhea

Diseases in the Diarrhea family:

Diarrhea 6 Diarrhea 9
Chronic Diarrhea Due to Guanylate Cyclase 2c Overactivity Inflammatory Diarrhea
Acute Diarrhea Congenital Diarrhea

Diseases related to Inflammatory Diarrhea via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 12)
# Related Disease Score Top Affiliating Genes
1 diarrhea 11.5
2 dysentery 10.0
3 cholera 9.9
4 enterocolitis 9.7
5 kawasaki disease 9.7
6 salmonellosis 9.7
7 shigellosis 9.7
8 campylobacteriosis 9.7
9 irritable bowel syndrome 9.7
10 diarrhea 1, secretory chloride, congenital 9.7 SLC9A3 SLC26A6
11 renal tubular acidosis 9.4 SLC9A3 SLC26A6
12 leptospirosis 9.4 SLC9A3 CXCL8

Graphical network of the top 20 diseases related to Inflammatory Diarrhea:



Diseases related to Inflammatory Diarrhea

Symptoms & Phenotypes for Inflammatory Diarrhea

GenomeRNAi Phenotypes related to Inflammatory Diarrhea according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased OCT4 protein expression GR00184-A-2 9.1 PITX1 SPI1
2 Decreased OCT4 protein expression GR00184-A-5 9.1 PITX1 SPI1
3 Decreased OCT4 protein expression GR00184-A-7 9.1 PITX1 SPI1

MGI Mouse Phenotypes related to Inflammatory Diarrhea:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.26 PITX1 SLC26A6 SLC9A3 VIPR1
2 endocrine/exocrine gland MP:0005379 9.02 PITX1 SLC26A6 SLC9A3 SPI1 VIPR1

Drugs & Therapeutics for Inflammatory Diarrhea

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Epidemiology of Chronic Diarrhea Among Children Admitted to Gastroenterology Unit at Assuit University Children Hospital Unknown status NCT03261297

Search NIH Clinical Center for Inflammatory Diarrhea

Genetic Tests for Inflammatory Diarrhea

Anatomical Context for Inflammatory Diarrhea

MalaCards organs/tissues related to Inflammatory Diarrhea:

41
Colon, Testes, Neutrophil, T Cells

Publications for Inflammatory Diarrhea

Articles related to Inflammatory Diarrhea:

(show top 50) (show all 115)
# Title Authors PMID Year
1
Comparative transcriptional analysis for Toll-like receptors, inflammatory cytokines, and apoptotic genes in response to different cytolethal-encoding and noncoding isolates of Salmonella enterica and Campylobacter jejuni from food and human stool. 38
31112773 2019
2
PhoP-Mediated Repression of the SPI1 Type 3 Secretion System in Salmonella enterica Serovar Typhimurium. 38
31182495 2019
3
The sRNA PinT contributes to PhoP-mediated regulation of the SPI1 T3SS in Salmonella enterica serovar Typhimurium. 38
31262841 2019
4
Hemorrhagic Fever with Renal Syndrome as a Cause of Acute Diarrhea. 38
30915955 2019
5
Oxygen-dependent regulation of SPI1 type three secretion system by small RNAs in Salmonella enterica serovar Typhimurium. 38
30484918 2019
6
Zinc ameliorates intestinal barrier dysfunctions in shigellosis by reinstating claudin-2 and -4 on the membranes. 38
30406698 2019
7
Serum procalcitonin levels can be used to differentiate between inflammatory and non-inflammatory diarrhea in acute infectious diarrhea. 38
30095641 2018
8
Clostridium difficile toxins A and B decrease intestinal SLC26A3 protein expression. 38
29597352 2018
9
Travelers' Diarrhea in Thailand: A Quantitative Analysis Using TaqMan® Array Card. 38
29351583 2018
10
Gastrointestinal Disorders Associated with Primary Immunodeficiency Diseases. 38
29754192 2018
11
HilE Regulates HilD by Blocking DNA Binding in Salmonella enterica Serovar Typhimurium. 38
29378886 2018
12
Equisetum telmateia extracts: Chemical compositions, antioxidant activity and antimicrobial effect on the growth of some pathogenic strain causing poisoning and infection. 38
29331369 2018
13
Clinical manifestation of Campylobacter enteritis in children. 38
29628968 2018
14
Different Age Distribution between Campylobacteriosis and Nontyphoidal Salmonellosis in Hospitalized Korean Children with Acute Inflammatory Diarrhea. 38
28581280 2017
15
Epidemiology of enteroaggregative Escherichia coli infections and associated outcomes in the MAL-ED birth cohort. 38
28742106 2017
16
Campylobacter: from microbiology to prevention. 38
28900347 2017
17
Administration of Wasabia koreana Ameliorates Irritable Bowel Syndrome-Like Symptoms in a Zymosan-Induced Mouse Model. 38
28452565 2017
18
Mesenteric venous thrombosis precipitated by foodborne gastrointestinal illness. 38
28473917 2017
19
Active Ingredients of Hange-shashin-to, Baicalelin and 6-Gingerol, Inhibit 5-Fluorouracil-Induced Upregulation of CXCL1 in the Colon to Attenuate Diarrhea Development. 38
29199237 2017
20
Salmonella enterica Serovar Typhimurium Strategies for Host Adaptation. 38
29075247 2017
21
[Clinical epidemiology and antimicrobial resistance of nontyphoidal Salmonella enteric infections in children: 2012-2014]. 38
27412737 2016
22
Intestinal Long-Chain Fatty Acids Act as a Direct Signal To Modulate Expression of the Salmonella Pathogenicity Island 1 Type III Secretion System. 38
26884427 2016
23
The Salmonella pathogenicity island 13 contributes to pathogenesis in streptomycin pre-treated mice but not in day-old chickens. 38
27141235 2016
24
Actin cytoskeleton-modulating T3SS2 effectors and their contribution to the Vibrio parahaemolyticus-induced diarrhea. 38
27980291 2016
25
Fecal detection of enterotoxigenic Bacteroides fragilis. 38
26173688 2015
26
Complete Genome Sequence of Salmonella enterica subsp. enterica Serovar Enteritidis Strain SEJ. 38
25342692 2014
27
Bacteroides fragilis subverts mucosal biology: from symbiont to colon carcinogenesis. 38
25105360 2014
28
Potential for developing purinergic drugs for gastrointestinal diseases. 38
24859298 2014
29
Acute diarrhea. 38
24506120 2014
30
Inflammatory diarrhea due to enteroaggregative Escherichia coli: evidence from clinical and mice model studies. 38
24294997 2013
31
Bacteroides fragilis Toxin Induces IL-8 Secretion in HT29/C1 Cells through Disruption of E-cadherin Junctions. 38
24198747 2013
32
Multiplex real-time PCR for detection of Campylobacter, Salmonella, and Shigella. 38
23761159 2013
33
Enterotoxigenic Bacteroides fragilis causes lethal colitis in Mongolian gerbils. 38
23538057 2013
34
Clinical approach and management of chronic diarrhea. 38
23770798 2013
35
Serum C-reactive protein (CRP) levels in young adults can be used to discriminate between inflammatory and non-inflammatory diarrhea. 38
22926497 2013
36
Human enteroids: preclinical models of non-inflammatory diarrhea. 38
24564938 2013
37
Clinical approach to diarrhea. 38
23073866 2012
38
Two live attenuated Shigella flexneri 2a strains WRSf2G12 and WRSf2G15: a new combination of gene deletions for 2nd generation live attenuated vaccine candidates. 38
22658966 2012
39
Increase in Campylobacter jejuni invasion of intestinal epithelial cells under low-oxygen coculture conditions that reflect the in vivo environment. 38
22354027 2012
40
Integrating global regulatory input into the Salmonella pathogenicity island 1 type III secretion system. 38
22021388 2012
41
Evaluation of chronic diarrhea. 38
22085666 2011
42
The insect peptide coprisin prevents Clostridium difficile-mediated acute inflammation and mucosal damage through selective antimicrobial activity. 38
21807975 2011
43
Knowledge, attitudes, and practice of travelers' diarrhea management among frontline providers. 38
21896094 2011
44
Antibiotic prescription for adults with acute diarrhea at King Chulalongkorn Memorial Hospital, Thailand. 38
21675442 2011
45
[Invasive gastroenteritis, anything new?]. 38
21458713 2011
46
FliZ regulates expression of the Salmonella pathogenicity island 1 invasion locus by controlling HilD protein activity in Salmonella enterica serovar typhimurium. 38
20889744 2010
47
Enteroaggregative Escherichia coli disrupts epithelial cell tight junctions. 38
20823198 2010
48
Bacteroides spp. and diarrhea. 38
20697287 2010
49
Enteroaggregative Escherichia coli (EAEC) impairs growth while malnutrition worsens EAEC infection: a novel murine model of the infection malnutrition cycle. 38
20594107 2010
50
Correction: The role of coupled positive feedback in the expression of the SPI1 type three secretion system in Salmonella. 38
20700452 2010

Variations for Inflammatory Diarrhea

Expression for Inflammatory Diarrhea

Search GEO for disease gene expression data for Inflammatory Diarrhea.

Pathways for Inflammatory Diarrhea

Pathways related to Inflammatory Diarrhea according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.34 VIPR1 SLC9A3 CXCL8
2 10.88 SLC9A3 SLC26A6
3 10.71 VIPR1 SPI1 CXCL8

GO Terms for Inflammatory Diarrhea

Cellular components related to Inflammatory Diarrhea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 vesicle GO:0031982 8.96 SLC9A3 SLC26A6
2 brush border membrane GO:0031526 8.62 SLC9A3 SLC26A6

Biological processes related to Inflammatory Diarrhea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of intracellular pH GO:0051453 8.62 SLC9A3 SLC26A6

Molecular functions related to Inflammatory Diarrhea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 PDZ domain binding GO:0030165 9.16 SLC9A3 SLC26A6
2 RNA polymerase II transcription factor binding GO:0001085 8.96 SPI1 PITX1
3 antiporter activity GO:0015297 8.62 SLC9A3 SLC26A6

Sources for Inflammatory Diarrhea

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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