MCID: INF002
MIFTS: 33

Inflammatory Diarrhea

Categories: Gastrointestinal diseases, Genetic diseases, Oral diseases, Rare diseases

Aliases & Classifications for Inflammatory Diarrhea

MalaCards integrated aliases for Inflammatory Diarrhea:

Name: Inflammatory Diarrhea 12 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:0050132
UMLS 71 C0521604

Summaries for Inflammatory Diarrhea

Disease Ontology : 12 A gastrointestinal system infectious disease involving diarrhea that occurs when there is damage to the mucosal lining or brush border, which leads to a passive loss of protein-rich fluids, and a decreased ability to absorb these lost fluids. It can be caused by bacterial infections, viral infections, parasitic infections, or autoimmune problems such as inflammatory bowel diseases. It can also be caused by tuberculosis, colon cancer, and enteritis.

MalaCards based summary : Inflammatory Diarrhea is related to diarrhea and intestinal impaction. An important gene associated with Inflammatory Diarrhea is PITX1 (Paired Like Homeodomain 1), and among its related pathways/superpathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and ADP signalling through P2Y purinoceptor 12. The drugs Nitazoxanide and Antiparasitic Agents have been mentioned in the context of this disorder. Affiliated tissues include colon, testes and t cells, and related phenotypes are digestive/alimentary and endocrine/exocrine gland

Related Diseases for Inflammatory Diarrhea

Diseases in the Diarrhea family:

Diarrhea 6 Diarrhea 9
Chronic Diarrhea Due to Guanylate Cyclase 2c Overactivity Inflammatory Diarrhea
Acute Diarrhea Congenital Diarrhea

Diseases related to Inflammatory Diarrhea via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 27)
# Related Disease Score Top Affiliating Genes
1 diarrhea 31.6 SLC9A3 SLC5A1 SLC26A3 CXCL8
2 intestinal impaction 10.3 SLC9A3 SLC26A3
3 corneal dystrophy, band-shaped 10.3 SLC9A8 SLC9A3
4 nephrolithiasis, uric acid 10.2 SLC9A3 SLC26A6
5 congenital diarrhea 10.2 SLC9A3 SLC26A3
6 acute diarrhea 10.1 SLC9A3R2 SLC9A3 PITX1
7 spermatocele 10.0 SLC9A3 SLC26A6 SLC26A3
8 diastrophic dysplasia 10.0 SLC26A6 SLC26A3
9 renal tubular acidosis 10.0 SLC9A8 SLC9A3 SLC26A6
10 dysentery 10.0
11 diarrhea 5, with tufting enteropathy, congenital 9.9 SLC5A1 SLC26A3
12 cholera 9.9
13 motility-related diarrhea 9.9 SLC9A2 SLC26A6 PDZD3
14 diarrhea 2, with microvillus atrophy 9.9 SLC9A3 SLC26A3
15 vulvovaginitis 9.8 SLC5A1 CXCL8
16 enterocolitis 9.7
17 kawasaki disease 9.7
18 salmonellosis 9.7
19 shigellosis 9.7
20 campylobacteriosis 9.7
21 irritable bowel syndrome 9.7
22 metaphyseal chondrodysplasia, jansen type 9.7 SLC9A3R1 CASR
23 osmotic diarrhea 9.6 SLC9A3 SLC9A2 SLC5A1 SLC26A3
24 bartter disease 9.6 SLC26A3 CASR
25 secretory diarrhea 9.6 SLC9A3R2 SLC9A3 SLC9A2 SLC26A3 PDZD3
26 diarrhea 1, secretory chloride, congenital 9.3 SLC9A8 SLC9A3 SLC9A2 SLC26A6 SLC26A3 PDZD3
27 nephrolithiasis, calcium oxalate 9.1 SLC9A3R1 SLC9A3 SLC26A6 PDZK1 CASR

Graphical network of the top 20 diseases related to Inflammatory Diarrhea:



Diseases related to Inflammatory Diarrhea

Symptoms & Phenotypes for Inflammatory Diarrhea

MGI Mouse Phenotypes related to Inflammatory Diarrhea:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.85 CASR PITX1 REG3G SLC26A3 SLC26A6 SLC5A1
2 endocrine/exocrine gland MP:0005379 9.56 CASR PITX1 SLC26A3 SLC26A6 SLC9A2 SLC9A3
3 homeostasis/metabolism MP:0005376 9.47 CASR PDZD3 PDZK1 PITX1 REG3G SLC26A3

Drugs & Therapeutics for Inflammatory Diarrhea

Drugs for Inflammatory Diarrhea (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Nitazoxanide Approved, Investigational, Vet_approved 55981-09-4 41684
2 Antiparasitic Agents
3 Acidophilus
4 Anti-Infective Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Epidemiology of Chronic Diarrhea Among Children Admitted to Gastroenterology Unit at Assuit University Children Hospital Unknown status NCT03261297
2 Development of an Effective Treatment of Cryptosporidiosis in Bangladeshi Children Not yet recruiting NCT04103216

Search NIH Clinical Center for Inflammatory Diarrhea

Genetic Tests for Inflammatory Diarrhea

Anatomical Context for Inflammatory Diarrhea

MalaCards organs/tissues related to Inflammatory Diarrhea:

40
Colon, Testes, T Cells, Neutrophil

Publications for Inflammatory Diarrhea

Articles related to Inflammatory Diarrhea:

(show top 50) (show all 117)
# Title Authors PMID Year
1
Idiopathic chronic diarrhea associated with dysbiosis in a captive cynomolgus macaque (Macaca fascicularis). 61
31642533 2020
2
A new role for heat shock factor 27 in the pathophysiology of Clostridium difficile toxin B. 61
31709831 2020
3
The Small RNA PinT Contributes to PhoP-Mediated Regulation of the Salmonella Pathogenicity Island 1 Type III Secretion System in Salmonella enterica Serovar Typhimurium. 61
31262841 2019
4
Gastrointestinal Disorders Associated with Primary Immunodeficiency Diseases. 61
29754192 2019
5
Comparative transcriptional analysis for Toll-like receptors, inflammatory cytokines, and apoptotic genes in response to different cytolethal-encoding and noncoding isolates of Salmonella enterica and Campylobacter jejuni from food and human stool. 61
31112773 2019
6
PhoP-Mediated Repression of the SPI1 Type 3 Secretion System in Salmonella enterica Serovar Typhimurium. 61
31182495 2019
7
Hemorrhagic Fever with Renal Syndrome as a Cause of Acute Diarrhea. 61
30915955 2019
8
Oxygen-dependent regulation of SPI1 type three secretion system by small RNAs in Salmonella enterica serovar Typhimurium. 61
30484918 2019
9
Zinc ameliorates intestinal barrier dysfunctions in shigellosis by reinstating claudin-2 and -4 on the membranes. 61
30406698 2019
10
Serum procalcitonin levels can be used to differentiate between inflammatory and non-inflammatory diarrhea in acute infectious diarrhea. 61
30095641 2018
11
Clostridium difficile toxins A and B decrease intestinal SLC26A3 protein expression. 61
29597352 2018
12
Travelers' Diarrhea in Thailand: A Quantitative Analysis Using TaqMan® Array Card. 61
29351583 2018
13
HilE Regulates HilD by Blocking DNA Binding in Salmonella enterica Serovar Typhimurium. 61
29378886 2018
14
Equisetum telmateia extracts: Chemical compositions, antioxidant activity and antimicrobial effect on the growth of some pathogenic strain causing poisoning and infection. 61
29331369 2018
15
Clinical manifestation of Campylobacter enteritis in children. 61
29628968 2018
16
Different Age Distribution between Campylobacteriosis and Nontyphoidal Salmonellosis in Hospitalized Korean Children with Acute Inflammatory Diarrhea. 61
28581280 2017
17
Epidemiology of enteroaggregative Escherichia coli infections and associated outcomes in the MAL-ED birth cohort. 61
28742106 2017
18
Campylobacter: from microbiology to prevention. 61
28900347 2017
19
Administration of Wasabia koreana Ameliorates Irritable Bowel Syndrome-Like Symptoms in a Zymosan-Induced Mouse Model. 61
28452565 2017
20
Mesenteric venous thrombosis precipitated by foodborne gastrointestinal illness. 61
28473917 2017
21
Active Ingredients of Hange-shashin-to, Baicalelin and 6-Gingerol, Inhibit 5-Fluorouracil-Induced Upregulation of CXCL1 in the Colon to Attenuate Diarrhea Development. 61
29199237 2017
22
Salmonella enterica Serovar Typhimurium Strategies for Host Adaptation. 61
29075247 2017
23
[Clinical epidemiology and antimicrobial resistance of nontyphoidal Salmonella enteric infections in children: 2012-2014]. 61
27412737 2016
24
Intestinal Long-Chain Fatty Acids Act as a Direct Signal To Modulate Expression of the Salmonella Pathogenicity Island 1 Type III Secretion System. 61
26884427 2016
25
The Salmonella pathogenicity island 13 contributes to pathogenesis in streptomycin pre-treated mice but not in day-old chickens. 61
27141235 2016
26
Actin cytoskeleton-modulating T3SS2 effectors and their contribution to the Vibrio parahaemolyticus-induced diarrhea. 61
27980291 2016
27
Fecal detection of enterotoxigenic Bacteroides fragilis. 61
26173688 2015
28
Complete Genome Sequence of Salmonella enterica subsp. enterica Serovar Enteritidis Strain SEJ. 61
25342692 2014
29
Bacteroides fragilis subverts mucosal biology: from symbiont to colon carcinogenesis. 61
25105360 2014
30
Potential for developing purinergic drugs for gastrointestinal diseases. 61
24859298 2014
31
Acute diarrhea. 61
24506120 2014
32
Inflammatory diarrhea due to enteroaggregative Escherichia coli: evidence from clinical and mice model studies. 61
24294997 2013
33
Bacteroides fragilis Toxin Induces IL-8 Secretion in HT29/C1 Cells through Disruption of E-cadherin Junctions. 61
24198747 2013
34
Multiplex real-time PCR for detection of Campylobacter, Salmonella, and Shigella. 61
23761159 2013
35
Enterotoxigenic Bacteroides fragilis causes lethal colitis in Mongolian gerbils. 61
23538057 2013
36
Clinical approach and management of chronic diarrhea. 61
23770798 2013
37
Serum C-reactive protein (CRP) levels in young adults can be used to discriminate between inflammatory and non-inflammatory diarrhea. 61
22926497 2013
38
Human enteroids: preclinical models of non-inflammatory diarrhea. 61
24564938 2013
39
Clinical approach to diarrhea. 61
23073866 2012
40
Two live attenuated Shigella flexneri 2a strains WRSf2G12 and WRSf2G15: a new combination of gene deletions for 2nd generation live attenuated vaccine candidates. 61
22658966 2012
41
Increase in Campylobacter jejuni invasion of intestinal epithelial cells under low-oxygen coculture conditions that reflect the in vivo environment. 61
22354027 2012
42
Integrating global regulatory input into the Salmonella pathogenicity island 1 type III secretion system. 61
22021388 2012
43
Evaluation of chronic diarrhea. 61
22085666 2011
44
The insect peptide coprisin prevents Clostridium difficile-mediated acute inflammation and mucosal damage through selective antimicrobial activity. 61
21807975 2011
45
Knowledge, attitudes, and practice of travelers' diarrhea management among frontline providers. 61
21896094 2011
46
Antibiotic prescription for adults with acute diarrhea at King Chulalongkorn Memorial Hospital, Thailand. 61
21675442 2011
47
[Invasive gastroenteritis, anything new?]. 61
21458713 2011
48
FliZ regulates expression of the Salmonella pathogenicity island 1 invasion locus by controlling HilD protein activity in Salmonella enterica serovar typhimurium. 61
20889744 2010
49
Enteroaggregative Escherichia coli disrupts epithelial cell tight junctions. 61
20823198 2010
50
Bacteroides spp. and diarrhea. 61
20697287 2010

Variations for Inflammatory Diarrhea

Expression for Inflammatory Diarrhea

Search GEO for disease gene expression data for Inflammatory Diarrhea.

Pathways for Inflammatory Diarrhea

Pathways related to Inflammatory Diarrhea according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.76 SLC9A8 SLC9A3 SLC9A2 SLC5A1 SLC26A6 SLC26A3
2
Show member pathways
11.76 SLC9A3R2 SLC9A3R1 SLC9A3 SLC9A2
3
Show member pathways
11.65 SLC9A3R2 SLC9A3R1 PDZK1
4 10.69 SLC9A3 SLC5A1 SLC26A6 SLC26A3

GO Terms for Inflammatory Diarrhea

Cellular components related to Inflammatory Diarrhea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell GO:0005623 9.8 SLC9A8 SLC9A3R1 SLC9A3 SLC9A2 SLC26A6 SLC26A3
2 apical plasma membrane GO:0016324 9.56 SLC9A3R2 SLC9A3R1 SLC9A3 SLC5A1 SLC26A6 SLC26A3
3 vesicle GO:0031982 9.54 SLC9A3R1 SLC9A3 SLC26A6
4 sperm midpiece GO:0097225 9.33 SLC9A3R1 SLC26A6 SLC26A3
5 microvillus membrane GO:0031528 9.32 SLC9A3R1 PDZK1
6 brush border membrane GO:0031526 9.1 SLC9A3R1 SLC9A3 SLC5A1 SLC26A6 SLC26A3 PDZK1

Biological processes related to Inflammatory Diarrhea according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 transmembrane transport GO:0055085 9.85 SLC9A8 SLC9A3 SLC9A2 SLC5A1 SLC26A6 SLC26A3
2 potassium ion transmembrane transport GO:0071805 9.74 SLC9A8 SLC9A3 SLC9A2
3 proton transmembrane transport GO:1902600 9.72 SLC9A8 SLC9A3 SLC9A2
4 ion transport GO:0006811 9.7 SLC9A8 SLC9A3 SLC9A2 SLC5A1 SLC26A6 SLC26A3
5 chloride transmembrane transport GO:1902476 9.67 SLC26A6 SLC26A3 CASR
6 cation transport GO:0006812 9.63 SLC9A8 SLC9A3 SLC9A2
7 sodium ion transport GO:0006814 9.62 SLC9A8 SLC9A3 SLC9A2 SLC5A1
8 sperm capacitation GO:0048240 9.58 SLC26A6 SLC26A3
9 anion transport GO:0006820 9.56 SLC26A6 SLC26A3
10 sulfate transport GO:0008272 9.54 SLC26A6 SLC26A3
11 sulfate transmembrane transport GO:1902358 9.52 SLC26A6 SLC26A3
12 sodium ion import across plasma membrane GO:0098719 9.51 SLC9A3 SLC9A2
13 oxalate transport GO:0019532 9.48 SLC26A6 SLC26A3
14 bile acid secretion GO:0032782 9.43 SLC9A3R1 CASR
15 regulation of pH GO:0006885 9.43 SLC9A8 SLC9A3 SLC9A2
16 intracellular pH elevation GO:0051454 9.4 SLC26A6 SLC26A3
17 regulation of intracellular pH GO:0051453 9.26 SLC9A8 SLC9A3 SLC9A2 SLC26A6
18 anion transmembrane transport GO:0098656 9.02 SLC9A8 SLC9A3 SLC9A2 SLC26A6 SLC26A3

Molecular functions related to Inflammatory Diarrhea according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 PDZ domain binding GO:0030165 9.62 SLC9A3R1 SLC9A3 SLC26A6 PDZK1
2 anion:anion antiporter activity GO:0015301 9.49 SLC26A6 SLC26A3
3 chloride transmembrane transporter activity GO:0015108 9.48 SLC26A6 SLC26A3
4 sulfate transmembrane transporter activity GO:0015116 9.46 SLC26A6 SLC26A3
5 bicarbonate transmembrane transporter activity GO:0015106 9.43 SLC26A6 SLC26A3
6 solute:proton antiporter activity GO:0015299 9.43 SLC9A8 SLC9A3 SLC9A2
7 secondary active sulfate transmembrane transporter activity GO:0008271 9.4 SLC26A6 SLC26A3
8 oxalate transmembrane transporter activity GO:0019531 9.37 SLC26A6 SLC26A3
9 sodium:proton antiporter activity GO:0015385 9.33 SLC9A8 SLC9A3 SLC9A2
10 potassium:proton antiporter activity GO:0015386 9.13 SLC9A8 SLC9A3 SLC9A2
11 antiporter activity GO:0015297 9.02 SLC9A8 SLC9A3 SLC9A2 SLC26A6 SLC26A3

Sources for Inflammatory Diarrhea

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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