MCID: INF002
MIFTS: 27

Inflammatory Diarrhea

Categories: Gastrointestinal diseases, Genetic diseases, Oral diseases, Rare diseases

Aliases & Classifications for Inflammatory Diarrhea

MalaCards integrated aliases for Inflammatory Diarrhea:

Name: Inflammatory Diarrhea 12 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:0050132
UMLS 74 C0521604

Summaries for Inflammatory Diarrhea

Disease Ontology : 12 A gastrointestinal system infectious disease involving diarrhea that occurs when there is damage to the mucosal lining or brush border, which leads to a passive loss of protein-rich fluids, and a decreased ability to absorb these lost fluids. It can be caused by bacterial infections, viral infections, parasitic infections, or autoimmune problems such as inflammatory bowel diseases. It can also be caused by tuberculosis, colon cancer, and enteritis.

MalaCards based summary : Inflammatory Diarrhea is related to diarrhea and diarrhea 2, with microvillus atrophy. An important gene associated with Inflammatory Diarrhea is SPI1 (Spi-1 Proto-Oncogene), and among its related pathways/superpathways are Glucocorticoid receptor regulatory network and Mineral absorption. Affiliated tissues include colon, and related phenotypes are digestive/alimentary and endocrine/exocrine gland

Related Diseases for Inflammatory Diarrhea

Diseases in the Diarrhea family:

Diarrhea 6 Diarrhea 9
Chronic Diarrhea Due to Guanylate Cyclase 2c Overactivity Inflammatory Diarrhea
Acute Diarrhea Congenital Diarrhea

Diseases related to Inflammatory Diarrhea via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 12)
# Related Disease Score Top Affiliating Genes
1 diarrhea 30.3 SLC26A3 SLC9A3
2 diarrhea 2, with microvillus atrophy 9.9 SLC26A3 SLC9A3
3 secretory diarrhea 9.9 SLC26A3 SLC9A3
4 deafness, autosomal recessive 6 9.8 SLC26A3 SLC26A6
5 kawasaki disease 9.7
6 salmonellosis 9.7
7 dysentery 9.7
8 campylobacteriosis 9.7
9 cholera 9.7
10 renal tubular acidosis 9.6 SLC26A6 SLC9A3
11 leptospirosis 9.6 CXCL8 SLC9A3
12 diarrhea 1, secretory chloride, congenital 9.6 SLC26A3 SLC26A6 SLC9A3

Graphical network of the top 20 diseases related to Inflammatory Diarrhea:



Diseases related to Inflammatory Diarrhea

Symptoms & Phenotypes for Inflammatory Diarrhea

MGI Mouse Phenotypes related to Inflammatory Diarrhea:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.26 PITX1 SLC26A3 SLC26A6 SLC9A3
2 endocrine/exocrine gland MP:0005379 9.02 PITX1 SLC26A3 SLC26A6 SLC9A3 SPI1

Drugs & Therapeutics for Inflammatory Diarrhea

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Epidemiology of Chronic Diarrhea Among Children Admitted to Gastroenterology Unit at Assuit University Children Hospital Recruiting NCT03261297

Search NIH Clinical Center for Inflammatory Diarrhea

Genetic Tests for Inflammatory Diarrhea

Anatomical Context for Inflammatory Diarrhea

MalaCards organs/tissues related to Inflammatory Diarrhea:

42
Colon

Publications for Inflammatory Diarrhea

Articles related to Inflammatory Diarrhea:

(show all 11)
# Title Authors Year
1
Serum procalcitonin levels can be used to differentiate between inflammatory and non-inflammatory diarrhea in acute infectious diarrhea. ( 30095641 )
2018
2
Different Age Distribution between Campylobacteriosis and Nontyphoidal Salmonellosis in Hospitalized Korean Children with Acute Inflammatory Diarrhea. ( 28581280 )
2017
3
Human enteroids: preclinical models of non-inflammatory diarrhea. ( 24564938 )
2013
4
Inflammatory diarrhea due to enteroaggregative Escherichia coli: evidence from clinical and mice model studies. ( 24294997 )
2013
5
Serum C-reactive protein (CRP) levels in young adults can be used to discriminate between inflammatory and non-inflammatory diarrhea. ( 22926497 )
2013
6
Diarrhea. Enterotoxigenic Bacteroides fragilis: newly recognized cause of inflammatory diarrhea. ( 19678432 )
2009
7
Association of enterotoxigenic Bacteroides fragilis infection with inflammatory diarrhea. ( 18680416 )
2008
8
Dangers of empiric oral ciprofloxacin in the treatment of acute inflammatory diarrhea in children. ( 11734755 )
2001
9
Mechanisms of inflammatory diarrhea. ( 1634090 )
1992
10
Clinical and immunologic significance of cholera-like toxin and cytotoxin production by Campylobacter species in patients with acute inflammatory diarrhea in the USA. ( 2760498 )
1989
11
Kawasaki disease presenting in an adult as inflammatory diarrhea. ( 3509115 )
1987

Variations for Inflammatory Diarrhea

Expression for Inflammatory Diarrhea

Search GEO for disease gene expression data for Inflammatory Diarrhea.

Pathways for Inflammatory Diarrhea

Pathways related to Inflammatory Diarrhea according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.87 CXCL8 SPI1
2 10.51 SLC26A3 SLC26A6 SLC9A3

GO Terms for Inflammatory Diarrhea

Cellular components related to Inflammatory Diarrhea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 apical plasma membrane GO:0016324 9.33 SLC26A3 SLC26A6 SLC9A3
2 sperm midpiece GO:0097225 8.96 SLC26A3 SLC26A6
3 brush border membrane GO:0031526 8.8 SLC26A3 SLC26A6 SLC9A3

Biological processes related to Inflammatory Diarrhea according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 ion transport GO:0006811 9.71 SLC26A3 SLC26A6 SLC9A3
2 transmembrane transport GO:0055085 9.7 SLC26A3 SLC26A6 SLC9A3
3 chloride transmembrane transport GO:1902476 9.51 SLC26A3 SLC26A6
4 chloride transport GO:0006821 9.49 SLC26A3 SLC26A6
5 cellular response to cAMP GO:0071320 9.48 SLC26A3 SLC26A6
6 bicarbonate transport GO:0015701 9.46 SLC26A3 SLC26A6
7 anion transmembrane transport GO:0098656 9.43 SLC26A3 SLC26A6
8 regulation of intracellular pH GO:0051453 9.4 SLC26A6 SLC9A3
9 sperm capacitation GO:0048240 9.37 SLC26A3 SLC26A6
10 anion transport GO:0006820 9.32 SLC26A3 SLC26A6
11 sulfate transport GO:0008272 9.26 SLC26A3 SLC26A6
12 sulfate transmembrane transport GO:1902358 9.16 SLC26A3 SLC26A6
13 oxalate transport GO:0019532 8.96 SLC26A3 SLC26A6
14 intracellular pH elevation GO:0051454 8.62 SLC26A3 SLC26A6

Molecular functions related to Inflammatory Diarrhea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 PDZ domain binding GO:0030165 9.46 SLC26A6 SLC9A3
2 RNA polymerase II transcription factor binding GO:0001085 9.43 PITX1 SPI1
3 anion:anion antiporter activity GO:0015301 9.4 SLC26A3 SLC26A6
4 sulfate transmembrane transporter activity GO:0015116 9.37 SLC26A3 SLC26A6
5 bicarbonate transmembrane transporter activity GO:0015106 9.32 SLC26A3 SLC26A6
6 chloride transmembrane transporter activity GO:0015108 9.26 SLC26A3 SLC26A6
7 secondary active sulfate transmembrane transporter activity GO:0008271 9.16 SLC26A3 SLC26A6
8 oxalate transmembrane transporter activity GO:0019531 8.96 SLC26A3 SLC26A6
9 antiporter activity GO:0015297 8.8 SLC26A3 SLC26A6 SLC9A3

Sources for Inflammatory Diarrhea

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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