MCID: INF002
MIFTS: 25

Inflammatory Diarrhea

Categories: Gastrointestinal diseases, Genetic diseases, Rare diseases

Aliases & Classifications for Inflammatory Diarrhea

MalaCards integrated aliases for Inflammatory Diarrhea:

Name: Inflammatory Diarrhea 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:0050132
UMLS 73 C0521604

Summaries for Inflammatory Diarrhea

Disease Ontology : 12 A gastrointestinal system infectious disease involving diarrhea that occurs when there is damage to the mucosal lining or brush border, which leads to a passive loss of protein-rich fluids, and a decreased ability to absorb these lost fluids. It can be caused by bacterial infections, viral infections, parasitic infections, or autoimmune problems such as inflammatory bowel diseases. It can also be caused by tuberculosis, colon cancer, and enteritis.

MalaCards based summary : Inflammatory Diarrhea is related to diarrhea and diarrhea 1, secretory chloride, congenital. An important gene associated with Inflammatory Diarrhea is PITX1 (Paired Like Homeodomain 1), and among its related pathways/superpathways are Toll Comparative Pathway and Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. Affiliated tissues include colon, and related phenotypes are digestive/alimentary and endocrine/exocrine gland

Related Diseases for Inflammatory Diarrhea

Diseases in the Diarrhea family:

Diarrhea 6 Diarrhea 7
Chronic Diarrhea Due to Guanylate Cyclase 2c Overactivity Inflammatory Diarrhea
Acute Diarrhea Congenital Diarrhea

Diseases related to Inflammatory Diarrhea via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 11)
# Related Disease Score Top Affiliating Genes
1 diarrhea 29.2 SLC26A3 SLC9A3
2 diarrhea 1, secretory chloride, congenital 9.9 SLC26A3 SLC9A3
3 diarrhea 2, with microvillus atrophy 9.8 SLC26A3 SLC9A3
4 secretory diarrhea 9.8 SLC26A3 SLC9A3
5 osmotic diarrhea 9.7 SLC26A3 SLC9A3
6 aging 9.6
7 kawasaki disease 9.6
8 salmonellosis 9.6
9 campylobacteriosis 9.6
10 cholera 9.6
11 leptospirosis 9.2 CXCL8 SLC9A3

Graphical network of the top 20 diseases related to Inflammatory Diarrhea:



Diseases related to Inflammatory Diarrhea

Symptoms & Phenotypes for Inflammatory Diarrhea

MGI Mouse Phenotypes related to Inflammatory Diarrhea:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.26 PITX1 SLC26A3 SLC9A3 VIPR1
2 endocrine/exocrine gland MP:0005379 9.02 PITX1 SLC26A3 SLC9A3 SPI1 VIPR1

Drugs & Therapeutics for Inflammatory Diarrhea

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Epidemiology of Chronic Diarrhea Among Children Admitted to Gastroenterology Unit at Assuit University Children Hospital Recruiting NCT03261297

Search NIH Clinical Center for Inflammatory Diarrhea

Genetic Tests for Inflammatory Diarrhea

Anatomical Context for Inflammatory Diarrhea

MalaCards organs/tissues related to Inflammatory Diarrhea:

41
Colon

Publications for Inflammatory Diarrhea

Articles related to Inflammatory Diarrhea:

# Title Authors Year
1
Different Age Distribution between Campylobacteriosis and Nontyphoidal Salmonellosis in Hospitalized Korean Children with Acute Inflammatory Diarrhea. ( 28581280 )
2017
2
Inflammatory diarrhea due to enteroaggregative Escherichia coli: evidence from clinical and mice model studies. ( 24294997 )
2013
3
Human enteroids: preclinical models of non-inflammatory diarrhea. ( 24564938 )
2013
4
Serum C-reactive protein (CRP) levels in young adults can be used to discriminate between inflammatory and non-inflammatory diarrhea. ( 22926497 )
2013
5
Diarrhea. Enterotoxigenic Bacteroides fragilis: newly recognized cause of inflammatory diarrhea. ( 19678432 )
2009
6
Association of enterotoxigenic Bacteroides fragilis infection with inflammatory diarrhea. ( 18680416 )
2008
7
Dangers of empiric oral ciprofloxacin in the treatment of acute inflammatory diarrhea in children. ( 11734755 )
2001
8
Mechanisms of inflammatory diarrhea. ( 1634090 )
1992
9
Clinical and immunologic significance of cholera-like toxin and cytotoxin production by Campylobacter species in patients with acute inflammatory diarrhea in the USA. ( 2760498 )
1989
10
Kawasaki disease presenting in an adult as inflammatory diarrhea. ( 3509115 )
1987

Variations for Inflammatory Diarrhea

Expression for Inflammatory Diarrhea

Search GEO for disease gene expression data for Inflammatory Diarrhea.

Pathways for Inflammatory Diarrhea

Pathways related to Inflammatory Diarrhea according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.55 CXCL8 SPI1
2 11.34 CXCL8 SLC9A3 VIPR1
3 10.86 SLC26A3 SLC9A3
4 10.71 CXCL8 SPI1 VIPR1

GO Terms for Inflammatory Diarrhea

Cellular components related to Inflammatory Diarrhea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 brush border membrane GO:0031526 8.62 SLC26A3 SLC9A3

Biological processes related to Inflammatory Diarrhea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of intracellular pH GO:0051453 8.62 SLC26A3 SLC9A3

Molecular functions related to Inflammatory Diarrhea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II transcription factor binding GO:0001085 8.96 PITX1 SPI1
2 antiporter activity GO:0015297 8.62 SLC26A3 SLC9A3

Sources for Inflammatory Diarrhea

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....