MCID: INF031
MIFTS: 28

Inflammatory Leiomyosarcoma

Categories: Cancer diseases, Muscle diseases, Rare diseases, Reproductive diseases
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Aliases & Classifications for Inflammatory Leiomyosarcoma

MalaCards integrated aliases for Inflammatory Leiomyosarcoma:

Name: Inflammatory Leiomyosarcoma 11 14 71

Classifications:



External Ids:

Disease Ontology 11 DOID:5251
NCIt 49 C27495
UMLS 71 C1334179

Summaries for Inflammatory Leiomyosarcoma

Disease Ontology: 11 A leiomyosarcoma that is characterized by a prominent intristic inflammatory component.

MalaCards based summary: Inflammatory Leiomyosarcoma is related to conventional leiomyosarcoma and fibrous histiocytoma. An important gene associated with Inflammatory Leiomyosarcoma is MYOG (Myogenin), and among its related pathways/superpathways are Mesenchymal Stem Cells and Lineage-specific Markers and miRs in Muscle Cell Differentiation. Affiliated tissues include skeletal muscle and skin, and related phenotypes are growth/size/body region and muscle

Related Diseases for Inflammatory Leiomyosarcoma

Diseases in the Leiomyosarcoma family:

Inflammatory Leiomyosarcoma

Diseases related to Inflammatory Leiomyosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 118)
# Related Disease Score Top Affiliating Genes
1 conventional leiomyosarcoma 30.4 PAX7 MYOG CALD1
2 fibrous histiocytoma 29.8 CALD1 ALK
3 inflammatory myofibroblastic tumor 29.2 MYOG MYOD1 CALD1 ALK
4 rhabdomyosarcoma 28.4 PAX7 NF1 MYOG MYOD1 MYF6 ALK
5 leiomyosarcoma 10.4
6 myofibroma 10.3 MYOG CALD1
7 vagina leiomyosarcoma 10.2 MYOG CALD1
8 sarcomatosis 10.2 MYOG CALD1
9 scrotum neoplasm 10.2 MYOG CALD1
10 endobronchial leiomyoma 10.2 MYOG CALD1
11 adult fibrosarcoma 10.2 MYOG CALD1
12 cervical polyp 10.2 MYOG CALD1
13 epithelioid leiomyosarcoma 10.2 MYOG CALD1
14 gallbladder sarcoma 10.2 MYOG MYOD1
15 extraosseous osteosarcoma 10.2 MYOG CALD1
16 liver sarcoma 10.2 MYOG CALD1
17 pineal region teratoma 10.2 MYOG MYOD1
18 parietal lobe neoplasm 10.2 MYOG MYOD1
19 botryoid rhabdomyosarcoma 10.2 MYOG MYOD1
20 prostate rhabdomyosarcoma 10.2 MYOG MYOD1
21 pulmonary vein leiomyosarcoma 10.2 MYOD1 CALD1
22 sarcomatoid squamous cell skin carcinoma 10.2 MYOG CALD1
23 heart sarcoma 10.2 MYOG CALD1
24 conventional fibrosarcoma 10.2 MYOD1 CALD1
25 prostate sarcoma 10.2 MYOG MYOD1
26 myoblastoma 10.2 MYOG MYOD1
27 vagina sarcoma 10.2 MYOG CALD1
28 retroperitoneal sarcoma 10.2 MYOG CALD1
29 prostate stromal sarcoma 10.2 MYOG MYOD1
30 heart cancer 10.2 MYOG CALD1
31 clear cell basal cell carcinoma 10.2 PAX7 MYOG
32 parameningeal embryonal rhabdomyosarcoma 10.2 PAX7 MYOG
33 extraosseous ewing sarcoma 10.2 MYOG MYOD1
34 pleomorphic liposarcoma 10.2 MYOG CALD1
35 pulmonary artery leiomyosarcoma 10.2 MYOD1 CALD1
36 perivascular tumor 10.2 MYOG CALD1
37 carey-fineman-ziter syndrome 1 10.1 PAX7 MYOG
38 malignant glandular tumor of peripheral nerve sheath 10.1 NF1 MYOG
39 mixed cell type cancer 10.1 MYOG CALD1
40 small intestine leiomyoma 10.1 NF1 CALD1
41 epithelioid malignant peripheral nerve sheath tumor 10.1 NF1 MYOG
42 subungual glomus tumor 10.1 NF1 CALD1
43 cutaneous fibrous histiocytoma 10.1
44 glomus tumor 10.1 NF1 CALD1
45 mesenchymal chondrosarcoma 10.1 MYOG MYOD1
46 gastric liposarcoma 10.1 NF1 CALD1
47 adult malignant schwannoma 10.1 NF1 MYOG
48 prostate embryonal rhabdomyosarcoma 10.1 MYOG MYOD1 CALD1
49 malignant mesenchymoma 10.1 MYOG MYOD1 CALD1
50 cervical adenosarcoma 10.1 MYOG MYOD1 CALD1

Graphical network of the top 20 diseases related to Inflammatory Leiomyosarcoma:



Diseases related to Inflammatory Leiomyosarcoma

Symptoms & Phenotypes for Inflammatory Leiomyosarcoma

MGI Mouse Phenotypes related to Inflammatory Leiomyosarcoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.91 ALK CALD1 ITGA7 MYF6 MYOD1 MYOG
2 muscle MP:0005369 9.87 CALD1 ITGA7 MYF6 MYOD1 MYOG NF1
3 normal MP:0002873 9.85 ALK MYF6 MYOD1 MYOG NF1 PAX7
4 neoplasm MP:0002006 9.8 ALK MYF6 MYOD1 NF1 PAX7
5 respiratory system MP:0005388 9.63 ALK MYF6 MYOD1 MYOG NF1 PAX7
6 skeleton MP:0005390 9.5 ALK ITGA7 MYF6 MYOD1 MYOG NF1
7 mortality/aging MP:0010768 9.28 ALK CALD1 ITGA7 MYF6 MYOD1 MYOG

Drugs & Therapeutics for Inflammatory Leiomyosarcoma

Search Clinical Trials, NIH Clinical Center for Inflammatory Leiomyosarcoma

Genetic Tests for Inflammatory Leiomyosarcoma

Anatomical Context for Inflammatory Leiomyosarcoma

Organs/tissues related to Inflammatory Leiomyosarcoma:

MalaCards : Skeletal Muscle, Skin

Publications for Inflammatory Leiomyosarcoma

Articles related to Inflammatory Leiomyosarcoma:

(show all 19)
# Title Authors PMID Year
1
Inflammatory leiomyosarcoma/rhabdomyoblastic tumor: A report of two cases with novel genetic findings. 62
35655404 2022
2
A Rare Case of A Low-Grade Inflammatory Leiomyosarcoma/Histiocyte-Rich Rhabdomyoblastic Tumor in the Neck of An Adolescent Male. 62
35642345 2022
3
Pulmonary "Inflammatory Leiomyosarcomas" Are Indolent Tumors With Diploid Genomes and No Convincing Rhabdomyoblastic Differentiation. 62
35175969 2022
4
Inflammatory leiomyosarcoma of the head and neck: Case report. 62
33934064 2021
5
"Inflammatory Leiomyosarcoma" and "Histiocyte-rich Rhabdomyoblastic Tumor": a clinicopathological, immunohistochemical and genetic study of 13 cases, with a proposal for reclassification as "Inflammatory Rhabdomyoblastic Tumor". 62
33318583 2021
6
Histiocyte-rich rhabdomyoblastic tumor: a report of two cases and a review of the differential diagnoses. 62
32514584 2021
7
Inflammatory leiomyosarcoma shows frequent co-expression of smooth and skeletal muscle markers supporting a primitive myogenic phenotype: a report of 9 cases with a proposal for reclassification as low-grade inflammatory myogenic tumor. 62
32078043 2020
8
Anaplastic Kaposi's Sarcoma of the Adrenal in an HIV-negative Patient With Literature Review. 62
30212382 2019
9
Inflammatory leiomyosarcoma is a distinct tumor characterized by near-haploidization, few somatic mutations, and a primitive myogenic gene expression signature. 62
28884746 2018
10
A long-living case of carotid aneurysm caused by inflammatory leiomyosarcoma. 62
27461101 2016
11
Retained heterodisomy is associated with high gene expression in hyperhaploid inflammatory leiomyosarcoma. 62
23019412 2012
12
Inflammatory leiomyosarcoma of the ankle: a case report and review of the literature. 62
16513508 2006
13
So-called "inflammatory leiomyosarcoma'': a series of 3 cases providing additional insights into a rare entity. 62
15864383 2005
14
[Inflammatory leiomyosarcoma: a case report]. 62
14597897 2003
15
Inflammatory leiomyosarcoma of the retroperitoneum. 62
12650517 2003
16
Malignant fibrous histiocytoma of the skin with marked inflammatory infiltrate: a sarcoma mimicking malignant lymphoma. 62
12140443 2002
17
Leiomyosarcoma of soft tissue in children: clinicopathologic analysis of 20 cases. 62
10403297 1999
18
Inflammatory leiomyosarcoma may be characterized by specific near-haploid chromosome changes. 62
9713368 1998
19
Inflammatory leiomyosarcoma: a morphological subgroup within the heterogeneous family of so-called inflammatory malignant fibrous histiocytoma. 62
8838332 1995

Variations for Inflammatory Leiomyosarcoma

Expression for Inflammatory Leiomyosarcoma

Search GEO for disease gene expression data for Inflammatory Leiomyosarcoma.

Pathways for Inflammatory Leiomyosarcoma

Pathways related to Inflammatory Leiomyosarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.11 PAX7 MYOG MYOD1
2 10.69 PAX7 MYOD1
3 10.28 MYOG MYOD1 MYF6

GO Terms for Inflammatory Leiomyosarcoma

Biological processes related to Inflammatory Leiomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 skeletal muscle cell differentiation GO:0035914 9.88 MYOG MYOD1 MYF6
2 positive regulation of myoblast differentiation GO:0045663 9.85 MYOG MYOD1 MYF6
3 positive regulation of skeletal muscle fiber development GO:0048743 9.73 MYF6 MYOD1 MYOG
4 anatomical structure development GO:0048856 9.72 PAX7 MYOG MYOD1 MYF6
5 muscle cell fate commitment GO:0042693 9.63 MYOG MYOD1 MYF6
6 muscle organ development GO:0007517 9.56 PAX7 MYOG MYOD1 MYF6 ITGA7
7 myotube differentiation GO:0014902 9.43 MYOG MYOD1
8 skeletal muscle tissue development GO:0007519 9.32 NF1 MYOG MYOD1 MYF6 ITGA7

Molecular functions related to Inflammatory Leiomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein dimerization activity GO:0046983 9.55 MYOG MYOD1 MYF6
2 E-box binding GO:0070888 9.1 MYOG MYOD1 MYF6
3 DNA-binding transcription activator activity GO:0001216 8.96 MYOG MYOD1

Sources for Inflammatory Leiomyosarcoma

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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