MCID: INF031
MIFTS: 30

Inflammatory Leiomyosarcoma

Categories: Cancer diseases, Muscle diseases, Rare diseases

Aliases & Classifications for Inflammatory Leiomyosarcoma

MalaCards integrated aliases for Inflammatory Leiomyosarcoma:

Name: Inflammatory Leiomyosarcoma 12 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:5251
NCIt 51 C27495
UMLS 74 C1334179

Summaries for Inflammatory Leiomyosarcoma

Disease Ontology : 12 A leiomyosarcoma that is characterized by a prominent intristic inflammatory component.

MalaCards based summary : Inflammatory Leiomyosarcoma is related to malignant fibroxanthoma and mesenchymoma. An important gene associated with Inflammatory Leiomyosarcoma is DES (Desmin), and among its related pathways/superpathways are Developmental Biology and Immune response Function of MEF2 in T lymphocytes. Related phenotypes are mortality/aging and growth/size/body region

Related Diseases for Inflammatory Leiomyosarcoma

Diseases in the Leiomyosarcoma family:

Inflammatory Leiomyosarcoma

Diseases related to Inflammatory Leiomyosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 48)
# Related Disease Score Top Affiliating Genes
1 malignant fibroxanthoma 29.7 DES MYOD1
2 mesenchymoma 10.3 DES MYOD1
3 leiomyosarcoma 10.2
4 breast rhabdomyosarcoma 10.2 MYOD1 MYOG
5 botryoid rhabdomyosarcoma 10.2 DES MYOD1
6 spindle cell rhabdomyosarcoma 10.2 DES MYOD1
7 undifferentiated embryonal sarcoma of the liver 10.2 MYOD1 MYOG
8 horner's syndrome 10.2 DES MYOD1
9 hemophagocytic lymphohistiocytosis, familial, 1 10.2 MYF6 MYOD1
10 giant cell myocarditis 10.2 CD68 DES
11 orbit rhabdomyosarcoma 10.2 MYOG NF1
12 adult fibrosarcoma 10.2 MYOD1 MYOG
13 spindle cell liposarcoma 10.1 MYOD1 MYOG
14 pleomorphic rhabdomyosarcoma 10.1 MYOD1 PAX7
15 neurilemmoma 10.1 DES NF1
16 ischemic fasciitis 10.1 CD68 DES
17 granular cell tumor 10.1 CD68 DES
18 gallbladder sarcoma 10.1 DES MYOD1 MYOG
19 embryonal sarcoma 10.1 DES MYOD1 MYOG
20 medullomyoblastoma 10.0 DES MYOD1 MYOG
21 alveolar soft part sarcoma 10.0 DES MYF6 MYOD1
22 congenital epulis 10.0 CD68 DES
23 trigeminal nerve neoplasm 10.0 CD68 NF1
24 neurilemmoma of the fifth cranial nerve 10.0 CD68 NF1
25 lung combined type small cell carcinoma 10.0 CALD1 MYOG
26 central nervous system mesenchymal non-meningothelial tumor 10.0 MYF6 MYOD1 PAX7
27 rhabdoid tumor predisposition syndrome 1 10.0 DES MYOD1
28 malignant triton tumor 9.9 DES MYOD1 NF1
29 inflammatory mfh 9.9 CALD1 CD68
30 conventional fibrosarcoma 9.9 CALD1 CD68
31 pseudosarcomatous fibromatosis 9.8 CALD1 DES MYOG
32 embryonal rhabdomyosarcoma 9.8 DES MYOD1 MYOG PAX7
33 rhabdomyosarcoma 2 9.8 DES MYOD1 MYOG PAX7
34 histiocytoma 9.8
35 fibrous histiocytoma 9.8
36 malignant fibrous histiocytoma of bone 9.8 CALD1 DES MYOD1
37 sarcomatoid squamous cell skin carcinoma 9.8 CALD1 CD68
38 cellular schwannoma 9.7 NF1 PAX7
39 skin sarcoma 9.7 CALD1 CD68
40 ewing sarcoma 9.7 DES MYOD1 MYOG PAX7
41 extraosseous ewing's sarcoma 9.7 MYF5 MYF6 MYOD1 MYOG
42 malignant mesenchymoma 9.6 CALD1 DES MYOD1 MYOG
43 nephrogenic adenofibroma 9.5 CALD1 MYOD1 MYOG NF1
44 skeletal muscle cancer 9.5 MYF5 MYF6 MYOD1 MYOG PAX7
45 rhabdomyosarcoma 9.3 DES MYF5 MYF6 MYOD1 MYOG PAX7
46 muscle cancer 9.0 CALD1 DES MYF5 MYOD1 MYOG PAX7
47 muscular disease 8.5 CALD1 CD68 ITGA7 MYF5 MYF6 MYOD1
48 conventional leiomyosarcoma 8.2 CALD1 CD68 ITGA7 MYF5 MYF6 MYOD1

Graphical network of the top 20 diseases related to Inflammatory Leiomyosarcoma:



Diseases related to Inflammatory Leiomyosarcoma

Symptoms & Phenotypes for Inflammatory Leiomyosarcoma

MGI Mouse Phenotypes related to Inflammatory Leiomyosarcoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 mortality/aging MP:0010768 10.01 DES ITGA7 MYF5 MYF6 MYOD1 MYOG
2 growth/size/body region MP:0005378 9.98 ITGA7 MYF5 MYF6 MYOD1 MYOG NF1
3 muscle MP:0005369 9.97 DES ITGA7 MYF5 MYF6 MYOD1 MYOG
4 no phenotypic analysis MP:0003012 9.73 CD68 MYF5 MYF6 MYOD1 MYOG PAX7
5 neoplasm MP:0002006 9.72 MYF5 MYF6 MYOD1 NF1 PAX7
6 normal MP:0002873 9.63 MYF5 MYF6 MYOD1 MYOG NF1 PAX7
7 respiratory system MP:0005388 9.43 MYF5 MYF6 MYOD1 MYOG NF1 PAX7
8 skeleton MP:0005390 9.23 CD68 ITGA7 MYF5 MYF6 MYOD1 MYOG

Drugs & Therapeutics for Inflammatory Leiomyosarcoma

Search Clinical Trials , NIH Clinical Center for Inflammatory Leiomyosarcoma

Genetic Tests for Inflammatory Leiomyosarcoma

Anatomical Context for Inflammatory Leiomyosarcoma

Publications for Inflammatory Leiomyosarcoma

Articles related to Inflammatory Leiomyosarcoma:

# Title Authors Year
1
Inflammatory leiomyosarcoma is a distinct tumor characterized by near-haploidization, few somatic mutations, and a primitive myogenic gene expression signature. ( 28884746 )
2017
2
A long-living case of carotid aneurysm caused by inflammatory leiomyosarcoma. ( 27461101 )
2016
3
Retained heterodisomy is associated with high gene expression in hyperhaploid inflammatory leiomyosarcoma. ( 23019412 )
2012
4
Inflammatory leiomyosarcoma of the ankle: a case report and review of the literature. ( 16513508 )
2006
5
So-called "inflammatory leiomyosarcoma'': a series of 3 cases providing additional insights into a rare entity. ( 15864383 )
2005
6
Inflammatory leiomyosarcoma of the retroperitoneum. ( 12650517 )
2003
7
Inflammatory leiomyosarcoma may be characterized by specific near-haploid chromosome changes. ( 9713368 )
1998
8
Inflammatory leiomyosarcoma: a morphological subgroup within the heterogeneous family of so-called inflammatory malignant fibrous histiocytoma. ( 8838332 )
1995

Variations for Inflammatory Leiomyosarcoma

Expression for Inflammatory Leiomyosarcoma

Search GEO for disease gene expression data for Inflammatory Leiomyosarcoma.

Pathways for Inflammatory Leiomyosarcoma

Pathways related to Inflammatory Leiomyosarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.87 MYF5 MYF6 MYOD1 MYOG NF1
2
Show member pathways
11.48 MYF6 MYOD1 MYOG
3 10.69 MYF5 MYOD1 PAX7
4
Show member pathways
10.69 MYF5 MYF6 MYOD1 MYOG

GO Terms for Inflammatory Leiomyosarcoma

Cellular components related to Inflammatory Leiomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 myofibril GO:0030016 8.62 CALD1 MYOD1

Biological processes related to Inflammatory Leiomyosarcoma according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 regulation of transcription, DNA-templated GO:0006355 9.99 MYF5 MYF6 MYOD1 MYOG PAX7
2 positive regulation of transcription by RNA polymerase II GO:0045944 9.95 MYF5 MYF6 MYOD1 MYOG PAX7
3 multicellular organism development GO:0007275 9.93 MYF5 MYF6 MYOD1 MYOG PAX7
4 skeletal muscle cell differentiation GO:0035914 9.76 MYF5 MYF6 MYOD1 MYOG
5 regulation of gene expression GO:0010468 9.75 MYOD1 NF1 PAX7
6 extracellular matrix organization GO:0030198 9.74 ITGA7 MYF5 NF1
7 positive regulation of muscle cell differentiation GO:0051149 9.71 MYF5 MYF6 MYOD1 MYOG
8 positive regulation of myoblast differentiation GO:0045663 9.67 MYF5 MYF6 MYOD1 MYOG
9 skeletal muscle tissue regeneration GO:0043403 9.65 MYF6 MYOG PAX7
10 muscle organ development GO:0007517 9.63 ITGA7 MYF5 MYF6 MYOD1 MYOG PAX7
11 positive regulation of myoblast fusion GO:1901741 9.62 MYF5 MYF6 MYOD1 MYOG
12 muscle tissue morphogenesis GO:0060415 9.61 MYF5 MYF6 PAX7
13 somitogenesis GO:0001756 9.6 MYF5 MYF6
14 cellular response to estradiol stimulus GO:0071392 9.58 MYOD1 MYOG
15 skeletal muscle fiber development GO:0048741 9.56 MYOD1 MYOG
16 positive regulation of skeletal muscle fiber development GO:0048743 9.56 MYF5 MYF6 MYOD1 MYOG
17 myoblast differentiation GO:0045445 9.52 MYOD1 MYOG
18 myotube differentiation GO:0014902 9.51 MYOD1 MYOG
19 regulation of cell-matrix adhesion GO:0001952 9.49 MYF5 NF1
20 muscle cell fate commitment GO:0042693 9.26 MYF5 MYF6 MYOD1 MYOG
21 skeletal muscle tissue development GO:0007519 9.1 MYF5 MYF6 MYOD1 MYOG NF1 PAX7

Molecular functions related to Inflammatory Leiomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 9.8 MYF5 MYF6 MYOD1 MYOG PAX7
2 DNA-binding transcription factor activity GO:0003700 9.73 MYF6 MYOD1 MYOG PAX7
3 sequence-specific DNA binding GO:0043565 9.67 MYF5 MYOD1 MYOG PAX7
4 protein heterodimerization activity GO:0046982 9.62 MYF5 MYF6 MYOD1 MYOG
5 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.56 MYF5 MYF6 MYOD1 MYOG
6 protein dimerization activity GO:0046983 9.46 MYF5 MYF6 MYOD1 MYOG
7 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 9.26 MYF5 MYF6 MYOD1 MYOG
8 E-box binding GO:0070888 8.92 MYF5 MYF6 MYOD1 MYOG

Sources for Inflammatory Leiomyosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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