MCID: INF031
MIFTS: 27

Inflammatory Leiomyosarcoma

Categories: Cancer diseases, Muscle diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Inflammatory Leiomyosarcoma

MalaCards integrated aliases for Inflammatory Leiomyosarcoma:

Name: Inflammatory Leiomyosarcoma 12 15 70

Classifications:



External Ids:

Disease Ontology 12 DOID:5251
NCIt 50 C27495
UMLS 70 C1334179

Summaries for Inflammatory Leiomyosarcoma

Disease Ontology : 12 A leiomyosarcoma that is characterized by a prominent intristic inflammatory component.

MalaCards based summary : Inflammatory Leiomyosarcoma is related to malignant fibrous histiocytoma and smooth muscle tumor. An important gene associated with Inflammatory Leiomyosarcoma is MYOG (Myogenin), and among its related pathways/superpathways are Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers and Myogenesis. Affiliated tissues include skeletal muscle, prostate and lung, and related phenotype is muscle.

Related Diseases for Inflammatory Leiomyosarcoma

Diseases in the Leiomyosarcoma family:

Inflammatory Leiomyosarcoma

Diseases related to Inflammatory Leiomyosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 97)
# Related Disease Score Top Affiliating Genes
1 malignant fibrous histiocytoma 30.0 MYOG MYOD1 DES
2 smooth muscle tumor 29.7 DES CALD1
3 inflammatory myofibroblastic tumor 29.2 DES CALD1
4 conventional leiomyosarcoma 28.9 PAX7 MYOG MYOD1 ITGA7 CALD1
5 leiomyosarcoma 10.3
6 medullomyoblastoma 10.2 MYOG DES
7 ectomesenchymoma 10.2 MYOG DES
8 orbit embryonal rhabdomyosarcoma 10.2 PAX7 MYOG
9 parameningeal embryonal rhabdomyosarcoma 10.2 PAX7 MYOG
10 bilateral retinoblastoma 10.2 MYOG DES
11 clear cell basal cell carcinoma 10.2 PAX7 MYOG
12 congenital fibrosarcoma 10.2 MYOG DES
13 orbit rhabdomyosarcoma 10.1 PAX7 MYOG
14 pineal region teratoma 10.1 MYOG MYOD1
15 skeletal muscle neoplasm 10.1 MYOG MYOD1
16 undifferentiated embryonal sarcoma of the liver 10.1 MYOG MYOD1
17 prostate rhabdomyosarcoma 10.1 MYOG MYOD1
18 prostate stromal sarcoma 10.1 MYOG MYOD1
19 extraosseous ewing sarcoma 10.1 MYOG MYOD1
20 lung combined type small cell carcinoma 10.1 MYOG CALD1
21 gas gangrene 10.1 MYOG MYOD1
22 endobronchial leiomyoma 10.1 MYOG CALD1
23 retroperitoneal sarcoma 10.1 MYOG CALD1
24 intravenous leiomyomatosis 10.1 DES CALD1
25 cutaneous leiomyosarcoma 10.1 DES CALD1
26 cellular leiomyoma 10.1 DES CALD1
27 vagina sarcoma 10.1 MYOG CALD1
28 lung leiomyosarcoma 10.1 MYOG CALD1
29 fibrous histiocytoma 10.0
30 uterus leiomyosarcoma 10.0 MYOG CALD1
31 angiolipoma 10.0 DES CALD1
32 uterine corpus sarcoma 10.0 MYOG CALD1
33 glomangioma 10.0 DES CALD1
34 emery-dreifuss muscular dystrophy 2, autosomal dominant 10.0 MYOG MYOD1
35 myofibroma 10.0 DES CALD1
36 mixed cell type cancer 10.0 MYOG CALD1
37 pleomorphic liposarcoma 10.0 DES CALD1
38 perivascular epithelioid cell tumor 10.0 DES CALD1
39 pulmonary vein leiomyosarcoma 10.0 MYOD1 CALD1
40 mesenchymal cell neoplasm 10.0 MYOG CALD1
41 infantile myofibromatosis 10.0 DES CALD1
42 glomus tumor 10.0 DES CALD1
43 ewing sarcoma 10.0 PAX7 MYOG DES
44 gallbladder sarcoma 10.0 MYOG MYOD1 DES
45 malignant triton tumor 10.0 MYOG MYOD1 DES
46 rare soft tissue tumor 10.0
47 botryoid rhabdomyosarcoma 10.0 MYOG MYOD1 DES
48 embryonal sarcoma 10.0 MYOG MYOD1 DES
49 spindle cell rhabdomyosarcoma 10.0 MYOG MYOD1 DES
50 lipomatosis, multiple 10.0 DES CALD1

Graphical network of the top 20 diseases related to Inflammatory Leiomyosarcoma:



Diseases related to Inflammatory Leiomyosarcoma

Symptoms & Phenotypes for Inflammatory Leiomyosarcoma

MGI Mouse Phenotypes related to Inflammatory Leiomyosarcoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 muscle MP:0005369 9.02 DES ITGA7 MYOD1 MYOG PAX7

Drugs & Therapeutics for Inflammatory Leiomyosarcoma

Search Clinical Trials , NIH Clinical Center for Inflammatory Leiomyosarcoma

Genetic Tests for Inflammatory Leiomyosarcoma

Anatomical Context for Inflammatory Leiomyosarcoma

MalaCards organs/tissues related to Inflammatory Leiomyosarcoma:

40
Skeletal Muscle, Prostate, Lung, Bone, Smooth Muscle, Liver, Breast

Publications for Inflammatory Leiomyosarcoma

Articles related to Inflammatory Leiomyosarcoma:

(show all 15)
# Title Authors PMID Year
1
"Inflammatory Leiomyosarcoma" and "Histiocyte-rich Rhabdomyoblastic Tumor": a clinicopathological, immunohistochemical and genetic study of 13 cases, with a proposal for reclassification as "Inflammatory Rhabdomyoblastic Tumor". 61
33318583 2021
2
Histiocyte-rich rhabdomyoblastic tumor: a report of two cases and a review of the differential diagnoses. 61
32514584 2021
3
Inflammatory leiomyosarcoma shows frequent co-expression of smooth and skeletal muscle markers supporting a primitive myogenic phenotype: a report of 9 cases with a proposal for reclassification as low-grade inflammatory myogenic tumor. 61
32078043 2020
4
Anaplastic Kaposi's Sarcoma of the Adrenal in an HIV-negative Patient With Literature Review. 61
30212382 2019
5
Inflammatory leiomyosarcoma is a distinct tumor characterized by near-haploidization, few somatic mutations, and a primitive myogenic gene expression signature. 61
28884746 2018
6
A long-living case of carotid aneurysm caused by inflammatory leiomyosarcoma. 61
27461101 2016
7
Retained heterodisomy is associated with high gene expression in hyperhaploid inflammatory leiomyosarcoma. 61
23019412 2012
8
Inflammatory leiomyosarcoma of the ankle: a case report and review of the literature. 61
16513508 2006
9
So-called "inflammatory leiomyosarcoma'': a series of 3 cases providing additional insights into a rare entity. 61
15864383 2005
10
[Inflammatory leiomyosarcoma: a case report]. 61
14597897 2003
11
Inflammatory leiomyosarcoma of the retroperitoneum. 61
12650517 2003
12
Malignant fibrous histiocytoma of the skin with marked inflammatory infiltrate: a sarcoma mimicking malignant lymphoma. 61
12140443 2002
13
Leiomyosarcoma of soft tissue in children: clinicopathologic analysis of 20 cases. 61
10403297 1999
14
Inflammatory leiomyosarcoma may be characterized by specific near-haploid chromosome changes. 61
9713368 1998
15
Inflammatory leiomyosarcoma: a morphological subgroup within the heterogeneous family of so-called inflammatory malignant fibrous histiocytoma. 61
8838332 1995

Variations for Inflammatory Leiomyosarcoma

Expression for Inflammatory Leiomyosarcoma

Search GEO for disease gene expression data for Inflammatory Leiomyosarcoma.

Pathways for Inflammatory Leiomyosarcoma

Pathways related to Inflammatory Leiomyosarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.9 PAX7 MYOG MYOD1 DES
2
Show member pathways
10.72 MYOG MYOD1

GO Terms for Inflammatory Leiomyosarcoma

Cellular components related to Inflammatory Leiomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 myofibril GO:0030016 8.62 MYOD1 CALD1

Biological processes related to Inflammatory Leiomyosarcoma according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 multicellular organism development GO:0007275 9.83 STIL PAX7 MYOG MYOD1
2 skeletal muscle tissue development GO:0007519 9.51 MYOG MYOD1
3 skeletal muscle cell differentiation GO:0035914 9.49 MYOG MYOD1
4 cellular response to estradiol stimulus GO:0071392 9.48 MYOG MYOD1
5 positive regulation of muscle cell differentiation GO:0051149 9.46 MYOG MYOD1
6 skeletal muscle fiber development GO:0048741 9.43 MYOG MYOD1
7 skeletal muscle tissue regeneration GO:0043403 9.4 MYOG MYOD1
8 positive regulation of myoblast differentiation GO:0045663 9.37 MYOG MYOD1
9 myoblast differentiation GO:0045445 9.32 MYOG MYOD1
10 myotube differentiation GO:0014902 9.26 MYOG MYOD1
11 positive regulation of skeletal muscle fiber development GO:0048743 9.16 MYOG MYOD1
12 muscle cell fate commitment GO:0042693 8.96 MYOG MYOD1
13 muscle organ development GO:0007517 8.92 PAX7 MYOG MYOD1 ITGA7

Molecular functions related to Inflammatory Leiomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 proximal promoter sequence-specific DNA binding GO:0000987 9.16 MYOG MYOD1
2 chromatin DNA binding GO:0031490 8.96 MYOG MYOD1
3 E-box binding GO:0070888 8.62 MYOG MYOD1

Sources for Inflammatory Leiomyosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
Content
Loading form....