MCID: INF031
MIFTS: 29

Inflammatory Leiomyosarcoma

Categories: Cancer diseases, Muscle diseases, Rare diseases

Aliases & Classifications for Inflammatory Leiomyosarcoma

MalaCards integrated aliases for Inflammatory Leiomyosarcoma:

Name: Inflammatory Leiomyosarcoma 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:5251
NCIt 50 C27495
UMLS 73 C1334179

Summaries for Inflammatory Leiomyosarcoma

MalaCards based summary : Inflammatory Leiomyosarcoma is related to malignant fibroxanthoma and cervical polyp. An important gene associated with Inflammatory Leiomyosarcoma is DES (Desmin), and among its related pathways/superpathways are Developmental Biology and Immune response Function of MEF2 in T lymphocytes. Related phenotypes are mortality/aging and growth/size/body region

Related Diseases for Inflammatory Leiomyosarcoma

Diseases in the Leiomyosarcoma family:

Inflammatory Leiomyosarcoma

Diseases related to Inflammatory Leiomyosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 48)
# Related Disease Score Top Affiliating Genes
1 malignant fibroxanthoma 29.6 DES MYOD1
2 cervical polyp 10.5 DES MYOD1
3 botryoid rhabdomyosarcoma 10.5 DES MYOD1
4 mesenchymoma 10.4 DES MYOD1
5 undifferentiated embryonal sarcoma of the liver 10.4 MYOD1 MYOG
6 spindle cell rhabdomyosarcoma 10.4 DES MYOD1
7 horner's syndrome 10.4 DES MYOD1
8 giant cell myocarditis 10.4 CD68 DES
9 orbit rhabdomyosarcoma 10.4 MYOG NF1
10 malignant triton tumor 10.4 DES NF1
11 hemophagocytic lymphohistiocytosis, familial, 1 10.4 MYF6 MYOD1
12 adult fibrosarcoma 10.3 MYOD1 MYOG
13 spindle cell liposarcoma 10.3 MYOD1 MYOG
14 pleomorphic rhabdomyosarcoma 10.3 MYOD1 PAX7
15 ischemic fasciitis 10.3 CD68 DES
16 granular cell tumor 10.2 CD68 DES
17 rhabdoid cancer 10.2 DES MYOD1
18 congenital epulis 10.2 CD68 DES
19 breast rhabdomyosarcoma 10.2 DES MYOD1 MYOG
20 gallbladder sarcoma 10.1 DES MYOD1 MYOG
21 embryonal sarcoma 10.1 DES MYOD1 MYOG
22 medullomyoblastoma 10.1 DES MYOD1 MYOG
23 leiomyosarcoma 10.1
24 alveolar soft part sarcoma 10.1 DES MYF6 MYOD1
25 lung combined type small cell carcinoma 10.0 CALD1 MYOG
26 central nervous system mesenchymal non-meningothelial tumor 9.9 MYF6 MYOD1 PAX7
27 pleomorphic lipoma 9.9 CD68 NF1
28 inflammatory mfh 9.7 CALD1 CD68
29 cellular schwannoma 9.7 NF1 PAX7
30 pseudosarcomatous fibromatosis 9.7 CALD1 DES MYOG
31 conventional fibrosarcoma 9.7 CALD1 CD68
32 embryonal rhabdomyosarcoma 9.7 DES MYOD1 MYOG PAX7
33 rhabdomyosarcoma 2 9.7 DES MYOD1 MYOG PAX7
34 histiocytoma 9.7
35 fibrous histiocytoma 9.7
36 aneurysm 9.7
37 neurilemmoma 9.6 DES NF1
38 malignant fibrous histiocytoma of bone 9.5 CALD1 DES MYOD1
39 ewing sarcoma 9.5 DES MYOD1 MYOG PAX7
40 skin sarcoma 9.5 CALD1 CD68
41 extraosseous ewing's sarcoma 9.3 MYF5 MYF6 MYOD1 MYOG
42 myopathy 9.3 DES ITGA7 MYF6 MYOD1
43 malignant mesenchymoma 9.2 CALD1 DES MYOD1 MYOG
44 nephrogenic adenofibroma 8.9 CALD1 MYOD1 MYOG NF1
45 skeletal muscle cancer 8.9 MYF5 MYF6 MYOD1 MYOG PAX7
46 rhabdomyosarcoma 8.5 DES MYF5 MYF6 MYOD1 MYOG PAX7
47 muscle cancer 8.0 CALD1 DES MYF5 MYOD1 MYOG PAX7
48 conventional leiomyosarcoma 6.2 CALD1 CD68 ITGA7 MYF5 MYF6 MYOD1

Graphical network of the top 20 diseases related to Inflammatory Leiomyosarcoma:



Diseases related to Inflammatory Leiomyosarcoma

Symptoms & Phenotypes for Inflammatory Leiomyosarcoma

MGI Mouse Phenotypes related to Inflammatory Leiomyosarcoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 mortality/aging MP:0010768 10.01 MYF6 PAX7 MYOD1 DES ITGA7 MYOG
2 growth/size/body region MP:0005378 9.98 MYF6 PAX7 MYOD1 ITGA7 MYOG MYF5
3 muscle MP:0005369 9.97 PAX7 MYOD1 DES MYOG ITGA7 MYF5
4 no phenotypic analysis MP:0003012 9.73 MYF6 PAX7 MYOD1 CD68 MYOG MYF5
5 neoplasm MP:0002006 9.72 MYF6 PAX7 MYOD1 MYF5 NF1
6 normal MP:0002873 9.63 MYF6 PAX7 MYOD1 MYOG MYF5 NF1
7 respiratory system MP:0005388 9.43 MYF6 PAX7 MYOD1 MYOG MYF5 NF1
8 skeleton MP:0005390 9.23 MYF6 PAX7 MYOD1 CD68 MYOG ITGA7

Drugs & Therapeutics for Inflammatory Leiomyosarcoma

Search Clinical Trials , NIH Clinical Center for Inflammatory Leiomyosarcoma

Genetic Tests for Inflammatory Leiomyosarcoma

Anatomical Context for Inflammatory Leiomyosarcoma

Publications for Inflammatory Leiomyosarcoma

Articles related to Inflammatory Leiomyosarcoma:

# Title Authors Year
1
Inflammatory leiomyosarcoma is a distinct tumor characterized by near-haploidization, few somatic mutations, and a primitive myogenic gene expression signature. ( 28884746 )
2017
2
A long-living case of carotid aneurysm caused by inflammatory leiomyosarcoma. ( 27461101 )
2016
3
Retained heterodisomy is associated with high gene expression in hyperhaploid inflammatory leiomyosarcoma. ( 23019412 )
2012
4
Inflammatory leiomyosarcoma of the ankle: a case report and review of the literature. ( 16513508 )
2006
5
So-called "inflammatory leiomyosarcoma'': a series of 3 cases providing additional insights into a rare entity. ( 15864383 )
2005
6
Inflammatory leiomyosarcoma of the retroperitoneum. ( 12650517 )
2003
7
Inflammatory leiomyosarcoma may be characterized by specific near-haploid chromosome changes. ( 9713368 )
1998
8
Inflammatory leiomyosarcoma: a morphological subgroup within the heterogeneous family of so-called inflammatory malignant fibrous histiocytoma. ( 8838332 )
1995

Variations for Inflammatory Leiomyosarcoma

Expression for Inflammatory Leiomyosarcoma

Search GEO for disease gene expression data for Inflammatory Leiomyosarcoma.

Pathways for Inflammatory Leiomyosarcoma

Pathways related to Inflammatory Leiomyosarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.87 MYF5 MYF6 MYOD1 MYOG NF1
2
Show member pathways
11.48 MYF6 MYOD1 MYOG
3 10.69 MYF5 MYOD1 PAX7
4
Show member pathways
10.69 MYF5 MYF6 MYOD1 MYOG

GO Terms for Inflammatory Leiomyosarcoma

Cellular components related to Inflammatory Leiomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 myofibril GO:0030016 8.62 CALD1 MYOD1

Biological processes related to Inflammatory Leiomyosarcoma according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 multicellular organism development GO:0007275 9.96 MYF5 MYF6 MYOD1 MYOG PAX7
2 positive regulation of transcription by RNA polymerase II GO:0045944 9.93 MYF5 MYF6 MYOD1 MYOG PAX7
3 regulation of gene expression GO:0010468 9.76 MYOD1 NF1 PAX7
4 skeletal muscle cell differentiation GO:0035914 9.76 MYF5 MYF6 MYOD1 MYOG
5 extracellular matrix organization GO:0030198 9.74 ITGA7 MYF5 NF1
6 positive regulation of muscle cell differentiation GO:0051149 9.71 MYF5 MYF6 MYOD1 MYOG
7 positive regulation of myoblast differentiation GO:0045663 9.67 MYF5 MYF6 MYOD1 MYOG
8 skeletal muscle tissue regeneration GO:0043403 9.65 MYF6 MYOG PAX7
9 muscle organ development GO:0007517 9.63 ITGA7 MYF5 MYF6 MYOD1 MYOG PAX7
10 positive regulation of myoblast fusion GO:1901741 9.62 MYF5 MYF6 MYOD1 MYOG
11 muscle tissue morphogenesis GO:0060415 9.61 MYF5 MYF6 PAX7
12 somitogenesis GO:0001756 9.59 MYF5 MYF6
13 cellular response to estradiol stimulus GO:0071392 9.58 MYOD1 MYOG
14 positive regulation of skeletal muscle fiber development GO:0048743 9.56 MYF5 MYF6 MYOD1 MYOG
15 skeletal muscle fiber development GO:0048741 9.55 MYOD1 MYOG
16 myoblast differentiation GO:0045445 9.52 MYOD1 MYOG
17 regulation of cell-matrix adhesion GO:0001952 9.51 MYF5 NF1
18 myotube differentiation GO:0014902 9.49 MYOD1 MYOG
19 muscle cell fate commitment GO:0042693 9.26 MYF5 MYF6 MYOD1 MYOG
20 skeletal muscle tissue development GO:0007519 9.1 MYF5 MYF6 MYOD1 MYOG NF1 PAX7

Molecular functions related to Inflammatory Leiomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0000981 9.83 MYF5 MYF6 MYOD1 MYOG PAX7
2 sequence-specific DNA binding GO:0043565 9.71 MYF5 MYOD1 MYOG PAX7
3 protein heterodimerization activity GO:0046982 9.67 MYF5 MYF6 MYOD1 MYOG
4 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.62 MYF5 MYF6 MYOD1 MYOG
5 protein dimerization activity GO:0046983 9.56 MYF5 MYF6 MYOD1 MYOG
6 core promoter binding GO:0001047 9.48 MYOD1 MYOG
7 chromatin DNA binding GO:0031490 9.46 MYOD1 MYOG
8 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding GO:0001228 9.46 MYF5 MYF6 MYOD1 MYOG
9 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding GO:0003705 9.26 MYF5 MYF6 MYOD1 MYOG
10 E-box binding GO:0070888 8.92 MYF5 MYF6 MYOD1 MYOG

Sources for Inflammatory Leiomyosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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