ILVEN
MCID: INF057
MIFTS: 34

Inflammatory Linear Verrucous Epidermal Nevus (ILVEN)

Categories: Cancer diseases, Rare diseases, Skin diseases

Aliases & Classifications for Inflammatory Linear Verrucous Epidermal Nevus

MalaCards integrated aliases for Inflammatory Linear Verrucous Epidermal Nevus:

Name: Inflammatory Linear Verrucous Epidermal Nevus 52 58 71
Verrucous Epidermal Nevus 52 71
Verrucous Nevus 52 58
Ilven 52 58
Inflammatory Linear Verrucous Epidermal Naevus 52
Linear Verrucose Epidermal Nevus 52
Linear Verrucous Epidermal Nevus 71

Classifications:

Orphanet: 58  
Rare skin diseases


External Ids:

ICD10 via Orphanet 33 Q82.5
UMLS via Orphanet 72 C0362030 C0473574
UMLS 71 C0362030 C0473574 C3179502

Summaries for Inflammatory Linear Verrucous Epidermal Nevus

NIH Rare Diseases : 52 Inflammatory linear verrucous epidermal nevus (ILVEN) is a type of skin overgrowth, called epidermal nevus . It is characterized by skin colored, brown, or reddish, wart-like papules (nevi). The nevi join to form patches or plaques that often follow a pattern on the skin known as the "lines of Blaschko ". The affected areas of the skin may be red, itchy, and inflamed. ILVEN typically presents from birth to early childhood and often is limited to one side of the lower half of the body. It affects females more often than males. It usually occurs alone; however, rarely ILVEN can be associated with other symptoms as part of an epidermal nevus syndrome . Rarely, ILVEN can become cancerous (for example, basal cell carcinoma or squamous cell carcinoma ). ILVEN is caused by a genetic change that occurs after conception (somatic mutation ). How this alteration leads to the signs and symptoms of ILVEN is not well understood. There is no one treatment or cure for ILVEN. Products used to soften the skin (emollients ), moisturizers, and topical steroids may be utilized to relieve symptoms of dryness and itching. Recently, several patients have been treated with laser therapy with good results.

MalaCards based summary : Inflammatory Linear Verrucous Epidermal Nevus, also known as verrucous epidermal nevus, is related to skin disease and verrucous nevus acanthokeratolytic. An important gene associated with Inflammatory Linear Verrucous Epidermal Nevus is CD8A (CD8a Molecule). Affiliated tissues include skin, bone and kidney.

Wikipedia : 74 Inflammatory Linear Verrucous Epidermal Nevus is a rare disease of the skin that presents as multiple,... more...

Related Diseases for Inflammatory Linear Verrucous Epidermal Nevus

Diseases related to Inflammatory Linear Verrucous Epidermal Nevus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 81)
# Related Disease Score Top Affiliating Genes
1 skin disease 29.4 KRT10 CD8A
2 verrucous nevus acanthokeratolytic 12.4
3 linear verrucous nevus syndrome 12.4
4 palmoplantar keratoderma, epidermolytic 12.2
5 epidermolytic nevus 11.6
6 nevus, epidermal 11.2
7 pustulosis of palm and sole 10.8
8 psoriasis 10.8
9 congenital heart defects, hamartomas of tongue, and polysyndactyly 10.5
10 keratosis 10.5
11 lichen planus 10.5
12 incontinentia pigmenti 10.4
13 papilloma 10.4
14 verruciform xanthoma of skin 10.4
15 linear lichen planus 10.4
16 basal cell carcinoma 10.3
17 lichen amyloidosis 10.3
18 anogenital venereal wart 10.2
19 vulvitis 10.2
20 thyroiditis 10.2
21 congenital hemidysplasia with ichthyosiform erythroderma and limb defects 10.2
22 epidermolytic hyperkeratosis 10.2
23 erythrokeratodermia variabilis et progressiva 1 10.2
24 ichthyosis vulgaris 10.2
25 schimmelpenning-feuerstein-mims syndrome 10.2
26 dowling-degos disease 1 10.2
27 mycosis fungoides 10.2
28 hypomelanosis of ito 10.2
29 psoriasis 3 10.2
30 nevoid hypermelanosis, linear and whorled 10.2
31 nevus comedonicus 10.2
32 erythrokeratodermia variabilis et progressiva 5 10.2
33 vertebral artery occlusion 10.2
34 ichthyosis 10.2
35 squamous cell carcinoma 10.2
36 epilepsy 10.2
37 dermatitis 10.2
38 porokeratosis 10.2
39 spongiotic dermatitis 10.2
40 arthritis 10.2
41 47,xyy 10.2
42 linear porokeratosis 10.2
43 lymphangiectasis 10.2
44 nevus mucinosis 10.2
45 posttransplant acute limbic encephalitis 10.2
46 autosomal dominant epidermolytic ichthyosis 10.2
47 regional odontodysplasia 10.2
48 acanthosis nigricans 10.1
49 cowden syndrome 1 10.1
50 proteus syndrome 10.1

Graphical network of the top 20 diseases related to Inflammatory Linear Verrucous Epidermal Nevus:



Diseases related to Inflammatory Linear Verrucous Epidermal Nevus

Symptoms & Phenotypes for Inflammatory Linear Verrucous Epidermal Nevus

Drugs & Therapeutics for Inflammatory Linear Verrucous Epidermal Nevus

Search Clinical Trials , NIH Clinical Center for Inflammatory Linear Verrucous Epidermal Nevus

Genetic Tests for Inflammatory Linear Verrucous Epidermal Nevus

Anatomical Context for Inflammatory Linear Verrucous Epidermal Nevus

MalaCards organs/tissues related to Inflammatory Linear Verrucous Epidermal Nevus:

40
Skin, Bone, Kidney, Pancreas, Testes

Publications for Inflammatory Linear Verrucous Epidermal Nevus

Articles related to Inflammatory Linear Verrucous Epidermal Nevus:

(show top 50) (show all 153)
# Title Authors PMID Year
1
Carbon dioxide laser versus erbium:YAG laser in treatment of epidermal verrucous nevus: a comparative randomized clinical study. 61 52
27796132 2017
2
Off-Label Therapeutic Potential of Crisaborole. 61
32133868 2020
3
Nail lichen striatus: Is dermoscopy useful for the diagnosis? 61
31359464 2019
4
Cloves Syndrome: A Rare Disorder of Overgrowth with Unusual Features - An Uncommon Phenotype? 61
31334068 2019
5
Successful treatment of inflammatory linear verrucous epidermal nevus (ILVEN) with 308-nm excimer laser: Patient patient required. 61
30648292 2019
6
Inflammatory linear verrucous epidermal nevus treated successfully with crisaborole ointment in a 5-year-old boy. 61
30838675 2019
7
Genetic variant in the NSDHL gene in a cat with multiple congenital lesions resembling inflammatory linear verrucous epidermal nevi. 61
30474267 2019
8
Connexin43 mutations linked to skin disease have augmented hemichannel activity. 61
30631135 2019
9
Verruciform xanthoma overlying inflammatory linear verrucous epidermal nevus and in broad segmental distribution. 61
30337284 2018
10
Treatment of inflammatory linear verrucous epidermal nevus pruritus with thalidomide. 61
30091521 2018
11
Inflammatory linear verrucous epidermal nevus associated with erosive monoarthritis. 61
29974513 2018
12
Inflammatory linear verrucous epidermal nevus responsive to 308-nm excimer laser treatment. 61
30235359 2018
13
CHILD syndrome mimicking verrucous nevus in a Chinese patient responded well to the topical therapy of compound of simvastatin and cholesterol. 61
29341259 2018
14
Reconstruction of a buttock defect after excision of inflammatory linear verrucous epidermal nevus. 61
29624795 2018
15
Widely Spread Unilateral Inflammatory Linear Verrucous Epidermal Nevus (ILVEN). 61
30022937 2018
16
Successful Treatment of Inflammatory Linear Verrucous Epidermal Nevus with Concomitant Psoriasis Using Etanercept. 61
29606943 2018
17
[Giant verrucous nevus in a 15-year old girl: about a case]. 61
30918576 2018
18
Dermoscopy of linear dermatosis along Blaschko's line in childhood: Lichen striatus versus inflammatory linear verrucous epidermal nevus. 61
28925078 2017
19
Is Ki-67, keratin 16, involucrin, and filaggrin immunostaining sufficient to diagnose inflammatory linear verrucous epidermal nevus? A report of eight cases and a comparison with psoriasis vulgaris. 61
29166506 2017
20
A Case of "Inflammatory Linear Verrucous Epidermal Nevus" (ILVEN) Treated with CO2 Laser Ablation. 61
28785331 2017
21
Inflammatory Linear Verrucous Epidermal Nevus with a Postzygotic GJA1 Mutation Is a Mosaic Erythrokeratodermia Variabilis et Progressiva. 61
27890787 2017
22
Inflammatory linear verrucous epidermal nevus: an unusual manifestation. 61
26426377 2017
23
ILVEN - COMPLETE REMISSION AFTER ADMINISTRATION OF TOPICAL CORTICOSTEROID (CASE REVIEW). 61
28452721 2017
24
The Successful Treatment of a Case of Linear Psoriasis with Ixekizumab. 61
29230331 2017
25
Genital/Perigenital Inflammatory Linear Verrucous Epidermal Nevus: A Case Series. 61
26677274 2015
26
Inflammatory linear verrucous epidermal nevus and regional odontodysplasia: A rare sorority. 61
26752881 2015
27
Linear Darier's disease: A case with bilateral presentation. 61
26500868 2015
28
Differential Diagnosis of Linear Eruptions in Children. 61
26312593 2015
29
The application of a carbon dioxide laser in the treatment of superficial oral mucosal lesions. 61
25974830 2015
30
A Case of Inflammatory Linear Verrucous Epidermal Nevus on the Upper Eyelid. 61
26120188 2015
31
Basal cell carcinoma arising on a verrucous epidermal nevus: a case report. 61
25848348 2015
32
A novel technique used in the treatment of inflammatory linear verrucous epidermal nevus: tangential excision. 61
25192746 2014
33
The challenge to diagnose a clinical case of inflammatory linear verrucous epidermal nevus: is there any ILVEN associated with human papillomavirus infection? 61
25467274 2014
34
Treatment of inflammatory linear verrucous epidermal nevus with 2940 nm erbium fractional laser. 61
24112692 2014
35
Inflammatory linear verrucous epidermal nevus with psoriasiform histology. 61
24700964 2014
36
Adult-onset verrucous nevus lipomatosus cutaneous superficialis. 61
23113758 2014
37
Giant inflammatory linear verrucous epidermal nevus: successfully treated with full thickness excision and skin grafting. 61
24249899 2013
38
Inflammatory linear verrucous epidermal nevus: why a combined laser therapy. 61
23692514 2013
39
Involucrin in the differential diagnosis between linear psoriasis and inflammatory linear verrucous epidermal nevus: a report of one case. 61
24068133 2013
40
Inflammatory linear verrucous epidermal nevus. 61
24640220 2013
41
A diagnostic dilemma: inflammatory linear verrucous epidermal nevus versus linear psoriasis. 61
23149170 2013
42
Inflammatory linear verrucous epidermal nevus in perineum and vulva: a report of two rare cases. 61
23716825 2013
43
Is it inflammatory linear verrucous epidermal nevus or linear psoriasis? 61
23652072 2013
44
Vulvar and perianal condyloma superimposed inflammatory linear verrucous epidermal nevus: a case report and review of the literature. 61
24396613 2013
45
Inflammatory linear verrucous epidermal nevus and epilepsy: remission during valproic acid therapy. 61
23377323 2013
46
Inflammatory linear verrucous epidermal nevus of the digits treated with surgical excision and skin grafting. 61
22882733 2012
47
An inflammatory verrucous epidermal nevus concomitant with psoriasis: treatment with adalimumab. 61
23122018 2012
48
Feline epidermal nevi resembling human inflammatory linear verrucous epidermal nevus. 61
22672841 2012
49
Development of squamous cell carcinoma on an inflammatory linear verrucous epidermal nevus in the genital area. 61
22838090 2012
50
Letter: Transient peripheral facial nerve paralysis after local anesthetic procedure. 61
22559030 2012

Variations for Inflammatory Linear Verrucous Epidermal Nevus

Cosmic variations for Inflammatory Linear Verrucous Epidermal Nevus:

9 (show top 50) (show all 3432)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM149268805 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.1261G>A p.G421R 16:72958885-72958885 6
2 COSM149259613 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.10847C>T p.S3616F 16:72787429-72787429 6
3 COSM149268792 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.5825G>A p.G1942E 16:72796857-72796857 6
4 COSM149268800 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.1655C>T p.S552F 16:72958491-72958491 6
5 COSM149304906 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.1991C>T p.S664F 16:72958155-72958155 6
6 COSM149331772 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.11050G>A p.D3684N 16:72787226-72787226 6
7 COSM149266372 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.2084C>T p.P695L 16:72958062-72958062 6
8 COSM101976974 XPO1 skin,NS,carcinoma,basal cell carcinoma c.782G>A p.R261Q 2:61496985-61496985 6
9 COSM87040659 TSC2 skin,NS,carcinoma,basal cell carcinoma c.869C>T p.P290L 16:2058767-2058767 6
10 COSM87027025 TSC2 skin,NS,carcinoma,basal cell carcinoma c.2060C>T p.S687F 16:2071897-2071897 6
11 COSM87028684 TSC2 skin,NS,carcinoma,basal cell carcinoma c.679T>A p.C227S 16:2056674-2056674 6
12 COSM90144180 TRAF7 skin,NS,carcinoma,basal cell carcinoma c.1802C>T p.T601I 16:2176104-2176104 6
13 COSM88644633 TP63 skin,NS,carcinoma,basal cell carcinoma c.1922C>T p.A641V 3:189894381-189894381 6
14 COSM87925664 TP53 skin,NS,carcinoma,basal cell carcinoma c.477C>T p.A159= 17:7675135-7675135 6
15 COSM87919454 TP53 skin,NS,carcinoma,basal cell carcinoma c.395A>T p.K132M 17:7675217-7675217 6
16 COSM88272290 TP53 skin,NS,carcinoma,basal cell carcinoma c.480G>C p.M160I 17:7675132-7675132 6
17 COSM87898709 TP53 skin,NS,carcinoma,basal cell carcinoma c.742C>T p.R248W 17:7674221-7674221 6
18 COSM87910628 TP53 skin,NS,carcinoma,basal cell carcinoma c.772G>A p.E258K 17:7674191-7674191 6
19 COSM88387703 TP53 skin,NS,carcinoma,basal cell carcinoma c.781A>T p.S261C 17:7674182-7674182 6
20 COSM87963219 TP53 skin,NS,carcinoma,basal cell carcinoma c.292C>T p.P98S 17:7676077-7676077 6
21 COSM87929396 TP53 skin,NS,carcinoma,basal cell carcinoma c.530C>T p.P177L 17:7675082-7675082 6
22 COSM87898723 TP53 skin,NS,carcinoma,basal cell carcinoma c.817C>T p.R273C 17:7673803-7673803 6
23 COSM88310572 TP53 skin,NS,carcinoma,basal cell carcinoma c.677G>C p.G226A 17:7674286-7674286 6
24 COSM87898714 TP53 skin,NS,carcinoma,basal cell carcinoma c.844C>T p.R282W 17:7673776-7673776 6
25 COSM87898991 TP53 skin,NS,carcinoma,basal cell carcinoma c.535C>T p.H179Y 17:7675077-7675077 6
26 COSM88408340 TP53 skin,NS,carcinoma,basal cell carcinoma c.899C>G p.P300R 17:7673721-7673721 6
27 COSM87906968 TP53 skin,NS,carcinoma,basal cell carcinoma c.833C>T p.P278L 17:7673787-7673787 6
28 COSM87910495 TP53 skin,NS,carcinoma,basal cell carcinoma c.832C>T p.P278S 17:7673788-7673788 6
29 COSM87899497 TP53 skin,NS,carcinoma,basal cell carcinoma c.586C>T p.R196* 17:7674945-7674945 6
30 COSM87906130 TP53 skin,NS,carcinoma,basal cell carcinoma c.854A>T p.E285V 17:7673766-7673766 6
31 COSM87919200 TP53 skin,NS,carcinoma,basal cell carcinoma c.511G>C p.E171Q 17:7675101-7675101 6
32 COSM87944274 TP53 skin,NS,carcinoma,basal cell carcinoma c.419C>T p.T140I 17:7675193-7675193 6
33 COSM87921224 TP53 skin,NS,carcinoma,basal cell carcinoma c.835G>A p.G279R 17:7673785-7673785 6
34 COSM87898567 TP53 skin,NS,carcinoma,basal cell carcinoma c.748C>T p.P250S 17:7674215-7674215 6
35 COSM87900980 TP53 skin,NS,carcinoma,basal cell carcinoma c.839G>A p.R280K 17:7673781-7673781 6
36 COSM87947692 TP53 skin,NS,carcinoma,basal cell carcinoma c.770T>C p.L257P 17:7674193-7674193 6
37 COSM87957813 TP53 skin,NS,carcinoma,basal cell carcinoma c.737T>G p.M246R 17:7674226-7674226 6
38 COSM87904406 TP53 skin,NS,carcinoma,basal cell carcinoma c.796G>A p.G266R 17:7673824-7673824 6
39 COSM87917387 TP53 skin,NS,carcinoma,basal cell carcinoma c.746G>C p.R249T 17:7674217-7674217 6
40 COSM87932688 TP53 skin,NS,carcinoma,basal cell carcinoma c.507G>A p.M169I 17:7675105-7675105 6
41 COSM87903307 TP53 skin,NS,carcinoma,basal cell carcinoma c.841G>A p.D281N 17:7673779-7673779 6
42 COSM87905687 TP53 skin,NS,carcinoma,basal cell carcinoma c.955A>G p.K319E 17:7673573-7673573 6
43 COSM87899661 TP53 skin,NS,carcinoma,basal cell carcinoma c.797G>A p.G266E 17:7673823-7673823 6
44 COSM87908365 TP53 skin,NS,carcinoma,basal cell carcinoma c.454C>T p.P152S 17:7675158-7675158 6
45 COSM87961406 TP53 skin,NS,carcinoma,basal cell carcinoma c.532C>A p.H178N 17:7675080-7675080 6
46 COSM87918616 TP53 skin,NS,carcinoma,basal cell carcinoma c.993+1G>A p.? 17:7673534-7673534 6
47 COSM87897745 TP53 skin,NS,carcinoma,basal cell carcinoma c.524G>A p.R175H 17:7675088-7675088 6
48 COSM87911563 TP53 skin,NS,carcinoma,basal cell carcinoma c.388C>T p.L130F 17:7675224-7675224 6
49 COSM87922049 TP53 skin,NS,carcinoma,basal cell carcinoma c.713G>T p.C238F 17:7674250-7674250 6
50 COSM87898431 TP53 skin,NS,carcinoma,basal cell carcinoma c.451C>T p.P151S 17:7675161-7675161 6

Expression for Inflammatory Linear Verrucous Epidermal Nevus

Search GEO for disease gene expression data for Inflammatory Linear Verrucous Epidermal Nevus.

Pathways for Inflammatory Linear Verrucous Epidermal Nevus

GO Terms for Inflammatory Linear Verrucous Epidermal Nevus

Sources for Inflammatory Linear Verrucous Epidermal Nevus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....