MCID: INF026
MIFTS: 25

Inflammatory Mfh

Categories: Cancer diseases

Aliases & Classifications for Inflammatory Mfh

MalaCards integrated aliases for Inflammatory Mfh:

Name: Inflammatory Mfh 12 15
Xanthosarcoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:6192
NCIt 50 C6497
UMLS 73 C1334180

Summaries for Inflammatory Mfh

MalaCards based summary : Inflammatory Mfh, also known as xanthosarcoma, is related to histiocytoma and malignant fibroxanthoma. An important gene associated with Inflammatory Mfh is MDM2 (MDM2 Proto-Oncogene), and among its related pathways/superpathways are Proteoglycans in cancer and Integrated Cancer Pathway. Affiliated tissues include bone, lung and skin.

Related Diseases for Inflammatory Mfh

Diseases related to Inflammatory Mfh via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 81)
# Related Disease Score Top Affiliating Genes
1 histiocytoma 30.3 MDM2 SERPINA3
2 malignant fibroxanthoma 29.9 CDK4 MDM2 SERPINA1 SERPINA3
3 ring chromosome 7 10.2 CDK4 MDM2
4 infiltrating angiolipoma 10.2 CDK4 MDM2
5 spindle cell lipoma 10.2 CDK4 MDM2
6 cellular myxoid liposarcoma 10.2 CDK4 MDM2
7 myxoid liposarcoma 10.2 CDK4 MDM2
8 lipoblastoma 10.2 CDK4 MDM2
9 bone osteosarcoma 10.2 CDK4 MDM2
10 atypical lipomatous tumor 10.2 CDK4 MDM2
11 periosteal chondrosarcoma 10.2 CDK4 MDM2
12 spindle cell liposarcoma 10.2 CDK4 MDM2
13 periosteal osteogenic sarcoma 10.2 CDK4 MDM2
14 dedifferentiated liposarcoma 10.2 CDK4 MDM2
15 infiltrating lipoma 10.2 CDK4 MDM2
16 cornea cancer 10.2 CDK4 GFAP
17 lipomatosis, multiple 10.2 CDK4 MDM2
18 anaplastic ependymoma 10.1 GFAP MDM2
19 childhood oligodendroglioma 10.1 GFAP MDM2
20 gliomatosis cerebri 10.1 GFAP MDM2
21 neurilemmoma 10.1 EZR GFAP
22 nodular tenosynovitis 10.1 CD68 SERPINA3
23 acinar cell cystadenocarcinoma 10.1 SERPINA1 SERPINA3
24 retinal cancer 10.1 CDK4 MDM2
25 myxosarcoma 10.1 CD68 MDM2
26 scrotal carcinoma 10.1 CD68 SERPINA3
27 adult medulloblastoma 10.1 GFAP MDM2
28 cutaneous solitary mastocytoma 10.1 SERPINA1 SERPINA3
29 plasma protein metabolism disease 10.1 SERPINA1 SERPINA3
30 trigeminal nerve neoplasm 10.1 CD68 GFAP
31 neurilemmoma of the fifth cranial nerve 10.1 CD68 GFAP
32 meningioma, radiation-induced 10.1 EZR GFAP
33 giant cell glioblastoma 10.1 GFAP MDM2
34 undifferentiated embryonal sarcoma of the liver 10.1 CDK4 MDM2 SERPINA3
35 embryonal sarcoma 10.1 CDK4 MDM2 SERPINA3
36 phacolytic glaucoma 10.1 CD68 SERPINA1
37 adult xanthogranuloma 10.1 CD68 SERPINA1
38 parasitic ichthyosporea infectious disease 10.1 CD68 SERPINA1
39 rhinosporidiosis 10.1 CD68 SERPINA1
40 xanthogranulomatous pyelonephritis 10.1 CD68 SERPINA3
41 papillary ependymoma 10.1 CD68 GFAP
42 rhinoscleroma 10.1 CD68 SERPINA1
43 xanthogranulomatous cholecystitis 10.1 CD68 SERPINA3
44 grade iii astrocytoma 10.0 CDK4 GFAP MDM2
45 nervous system cancer 10.0 CDK4 GFAP MDM2
46 rhabdomyosarcoma 10.0 CDK4 EZR MDM2
47 cogan syndrome 10.0 GFAP SERPINA1
48 mixed liposarcoma 10.0 CD68 CDK4 MDM2
49 chondroid lipoma 10.0 CD68 CDK4 MDM2
50 ischemic fasciitis 10.0 CD68 CDK4 MDM2

Graphical network of the top 20 diseases related to Inflammatory Mfh:



Diseases related to Inflammatory Mfh

Symptoms & Phenotypes for Inflammatory Mfh

Drugs & Therapeutics for Inflammatory Mfh

Search Clinical Trials , NIH Clinical Center for Inflammatory Mfh

Genetic Tests for Inflammatory Mfh

Anatomical Context for Inflammatory Mfh

MalaCards organs/tissues related to Inflammatory Mfh:

41
Bone, Lung, Skin, Brain, Liver

Publications for Inflammatory Mfh

Articles related to Inflammatory Mfh:

# Title Authors Year
1
Malignant fibrous histiocytoma (malignant fibrous xanthoma: xanthosarcoma) of bone. ( 209886 )
1978
2
Retroperitoneal xanthogranuloma and xanthosarcoma (malignant fibrous xanthoma). ( 4347188 )
1973
3
XANTHOSARCOMA OF THUMB: A CENTRAL BENIGN GIANT-CELL TUMOR OF THE PROXIMAL PHALANX OF THE THUMB. ( 17865243 )
1925

Variations for Inflammatory Mfh

Expression for Inflammatory Mfh

Search GEO for disease gene expression data for Inflammatory Mfh.

Pathways for Inflammatory Mfh

Pathways related to Inflammatory Mfh according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.1 EZR FRS2 MDM2
2 10.92 CDK4 MDM2
3 10.8 CDK4 MDM2
4 10.46 CDK4 MDM2

GO Terms for Inflammatory Mfh

Cellular components related to Inflammatory Mfh according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 astrocyte projection GO:0097449 8.62 EZR GFAP

Biological processes related to Inflammatory Mfh according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell cycle GO:0045787 9.32 CDK4 MDM2
2 lens development in camera-type eye GO:0002088 9.26 CDK4 FRS2
3 acute-phase response GO:0006953 9.16 SERPINA1 SERPINA3
4 ventricular septum development GO:0003281 8.96 FRS2 MDM2
5 negative regulation of cell cycle arrest GO:0071157 8.62 CDK4 MDM2

Molecular functions related to Inflammatory Mfh according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 disordered domain specific binding GO:0097718 8.62 EZR MDM2

Sources for Inflammatory Mfh

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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