Inflammatory Myofibroblastic Tumor disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: INF058 MIFTS: 45	Inflammatory Myofibroblastic Tumor Categories: Cancer diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs Expand all tables

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Aliases & Classifications for Inflammatory Myofibroblastic Tumor

MalaCards integrated aliases for Inflammatory Myofibroblastic Tumor:

Name: Inflammatory Myofibroblastic Tumor ¹² ⁵² ⁵⁸ ¹⁵ ⁷¹

Inflammatory Fibrosarcoma ⁵²

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0050905

UMLS via Orphanet ⁷² C0334121

Orphanet ⁵⁸ ORPHA178342

UMLS ⁷¹ C0334121

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Summaries for Inflammatory Myofibroblastic Tumor

NIH Rare Diseases : ⁵² An inflammatory myofibroblastic tumor (IMT) is an uncommon, usually benign (non-cancerous) tumor made up of cells called myofibroblastic spindle cells. It usually develops in children or young adults, but can affect people of any age. An IMT can occur in almost any part of the body but is most commonly found in the lung, orbit (eye socket), peritoneum (lining of the abdominal cavity and internal organs ), and mesentery . Signs and symptoms vary depending on the site of the tumor. Some people with an IMT are asymptomatic, while others may have nonspecific respiratory symptoms, fever, or pain. IMTs may recur, and become locally invasive and/or spread (metastasize ) to other parts of the body. However, malignant (cancerous) IMTs are rare. The underlying cause of IMTs is poorly understood. Some cases have been linked to translocations involving the ALK gene . Treatment involves surgical removal when possible, although there are reports of treatment with oral steroids and radiation therapy .

MalaCards based summary : Inflammatory Myofibroblastic Tumor, also known as inflammatory fibrosarcoma, is related to epithelioid inflammatory myofibroblastic sarcoma and rare tumor, and has symptoms including fever and pain. An important gene associated with Inflammatory Myofibroblastic Tumor is ALK (ALK Receptor Tyrosine Kinase), and among its related pathways/superpathways are Endometrial cancer and Measles. The drugs Tyrosine and Crizotinib have been mentioned in the context of this disorder. Affiliated tissues include lung, liver and eye, and related phenotypes are Decreased cell migration and Decreased cell migration

Disease Ontology : ¹² A mesenchymal cell neoplasm that has material basis in myofibroblastic cells admixed with inflammatory cells.

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Related Diseases for Inflammatory Myofibroblastic Tumor

Diseases related to Inflammatory Myofibroblastic Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 429)

#	Related Disease	Score	Top Affiliating Genes
1	epithelioid inflammatory myofibroblastic sarcoma	33.3	TPM4 TPM3 SEC31A RANBP2 ALK
2	rare tumor	32.1	KIT CR2 ACTC1
3	pseudosarcomatous fibromatosis	31.5	VIM ALK ACTC1
4	fibrosarcoma	31.5	VIM TP53 KIT ALK ACTC1
5	anaplastic large cell lymphoma	31.5	RNF213 NPM1 ALK ACVRL1
6	fasciitis	31.4	VIM TP53 ACTC1
7	spindle cell sarcoma	31.4	VIM MDM2 ACTC1
8	fibrous histiocytoma	31.4	VIM TP53 KIT ALK ACTC1
9	leiomyosarcoma	31.3	VIM TP53 MDM2 KIT CDK4 ACTC1
10	gastrointestinal stromal tumor	31.2	VIM TP53 KIT ACTC1
11	liposarcoma	31.2	VIM TP53 MDM2 CDK4
12	carcinosarcoma	31.1	VIM TP53 KIT ACTC1
13	smooth muscle tumor	31.1	VIM KIT CR2 ACTC1
14	rhabdomyosarcoma	31.1	VIM TP53 MDM2 KIT CDK4 ALK
15	embryonal rhabdomyosarcoma	31.1	TP53 MDM2 CDK4 ACTC1
16	retroperitoneal fibrosis	31.1	VIM MDM2
17	soft tissue sarcoma	31.0	TP53 MDM2
18	lymphoma	31.0	TP53 RNF213 NPM1 MDM2 KIT EML4
19	congenital fibrosarcoma	31.0	VIM TPM3 ALK ACTC1
20	dendritic cell tumor	30.9	VIM CR2 CR1 ACTC1
21	dedifferentiated liposarcoma	30.9	TP53 MDM2 KIT CDK4 ACTC1
22	malignant fibrous histiocytoma	30.9	VIM TP53 MDM2 KIT CDK4 ACTC1
23	teratoma	30.9	VIM TP53 KIT ACTC1
24	endometrial stromal sarcoma	30.9	VIM TP53 KIT ACTC1
25	angiosarcoma	30.8	VIM TP53 MDM2 KIT
26	alk-positive anaplastic large cell lymphoma	30.8	NPM1 ALK
27	inflammatory liposarcoma	30.8	MDM2 ALK
28	pneumothorax	30.8	VIM ALK ACTC1
29	b-cell lymphoma	30.8	TP53 NPM1 MDM2 CR2 CDK4 ALK
30	perineurioma	30.8	VIM KIT ALK ACTC1
31	embryonal sarcoma	30.7	VIM TP53 MDM2 KIT CDK4
32	adenocarcinoma	30.7	TP53 MDM2 KIT CDK4 ALK
33	hemangiopericytoma, malignant	30.7	VIM MDM2 KIT ACTC1
34	ring chromosome	30.7	TP53 MDM2 CDK4
35	neurofibroma	30.7	VIM TP53 KIT ACTC1
36	connective tissue benign neoplasm	30.6	TP53 MDM2 KIT CDK4
37	well-differentiated liposarcoma	30.6	TP53 MDM2 KIT CDK4
38	sarcoma	30.5	VIM TP53 NPM1 MDM2 KIT CDK4
39	mesenchymal cell neoplasm	30.5	TPM4 TPM3 TP53 RANBP2 NPM1 KIT
40	neuroblastoma	30.5	TP53 NPM1 MDM2 KIT EML4 CDK4
41	diffuse large b-cell lymphoma	30.5	TP53 MDM2 CDK4 ALK
42	malignant peripheral nerve sheath tumor	30.4	VIM TP53 MDM2 KIT CDK4 ACTC1
43	ewing sarcoma	30.4	VIM TP53 MDM2 KIT CDK4 ALK
44	lymphoma, non-hodgkin, familial	30.3	TP53 NPM1 MDM2 CR2 ALK
45	lung cancer susceptibility 3	30.3	TP53 MDM2 KIT EML4 CDK4 ALK
46	desmoid tumor	11.7
47	infantile myofibromatosis	11.7
48	liver inflammatory pseudotumor	11.5
49	lymphangiectasis	10.7	VIM ACTC1
50	intravascular papillary endothelial hyperplasia	10.7	VIM ACTC1

Graphical network of the top 20 diseases related to Inflammatory Myofibroblastic Tumor:

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Symptoms & Phenotypes for Inflammatory Myofibroblastic Tumor

UMLS symptoms related to Inflammatory Myofibroblastic Tumor:

fever, pain

GenomeRNAi Phenotypes related to Inflammatory Myofibroblastic Tumor according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased cell migration	GR00055-A-1	9.26	ALK CDK4 VIM
2	Decreased cell migration	GR00055-A-3	9.26	TPM4
3	Decreased substrate adherent cell growth	GR00193-A-1	9.23	ACVRL1 KIT
4	Decreased substrate adherent cell growth	GR00193-A-2	9.23	CDK4 KIT
5	Decreased substrate adherent cell growth	GR00193-A-3	9.23	CDK4
6	Decreased substrate adherent cell growth	GR00193-A-4	9.23	ACVRL1 CDK4 KIT

MGI Mouse Phenotypes related to Inflammatory Myofibroblastic Tumor:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	muscle	MP:0005369	9.56	ACTC1 ACVRL1 CDK4 KIT MDM2 TP53
2	pigmentation	MP:0001186	9.02	ALK CDK4 KIT MDM2 TP53

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Drugs & Therapeutics for Inflammatory Myofibroblastic Tumor

Drugs for Inflammatory Myofibroblastic Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Tyrosine

Approved, Investigational, Nutraceutical

Phase 2, Phase 3

60-18-4

6057

Synonyms:

(-)-a-amino-P-Hydroxyhydrocinnamate

(-)-a-amino-P-Hydroxyhydrocinnamic acid

(-)-alpha-amino-P-Hydroxyhydrocinnamate

(-)-alpha-amino-P-Hydroxyhydrocinnamic acid

(-)-alpha-Amino-p-hydroxyhydrocinnamic acid

(-)-α-amino-P-hydroxyhydrocinnamate

(−)-α-amino-p-hydroxyhydrocinnamic acid

(-)-α-amino-P-hydroxyhydrocinnamic acid

(2S)-2-amino-3-(4-Hydroxyphenyl)propanoate

(2S)-2-amino-3-(4-hydroxyphenyl)propanoic acid

(2S)-2-amino-3-(4-Hydroxyphenyl)propanoic acid

(S)-(-)-Tyrosine

(S)-2-Amino-3-(4-hydroxyphenyl)propionic acid

(S)-2-amino-3-(P-Hydroxyphenyl)propionate

(S)-2-amino-3-(P-Hydroxyphenyl)propionic acid

(S)-2-Amino-3-(p-hydroxyphenyl)propionic acid

(S)-3-(p-Hydroxyphenyl)alanine

(S)-3-(P-Hydroxyphenyl)alanine

(S)-a-amino-4-Hydroxybenzenepropanoate

(S)-a-amino-4-Hydroxy-benzenepropanoate

(S)-a-amino-4-Hydroxybenzenepropanoic acid

(S)-a-amino-4-Hydroxy-benzenepropanoic acid

(S)-alpha-amino-4-Hydroxybenzenepropanoate

(S)-alpha-amino-4-Hydroxy-benzenepropanoate

(S)-alpha-amino-4-Hydroxybenzenepropanoic acid

(S)-alpha-amino-4-Hydroxy-benzenepropanoic acid

(S)-alpha-Amino-4-hydroxybenzenepropanoic acid

(S)-Tyrosine

(S)-α-amino-4-hydroxybenzenepropanoate

(S)-α-amino-4-hydroxybenzenepropanoic acid

140-43-2

1991-85-1

25619-78-7

2-amino-3-(4-Hydroxyphen yl)-2-amino-3-(4-hydroxyphenyl)-propanoate

2-amino-3-(4-Hydroxyphen yl)-2-amino-3-(4-hydroxyphenyl)-propanoic acid

2-Amino-3-(p-hydroxyphenyl)propionic acid

2csm

3-(4-Hydroxyphenyl)-L-alanine

3-(p-Hydroxyphenyl)alanine

46209-14-7

4-hydroxy-L-phenylalanine

4-Hydroxy-L-phenylalanine

4ts1

55520-40-6

60-18-4

93829_FLUKA

93829_SIGMA

AB1002647

AC-11295

AC1L1LPI

AC1Q4U7L

AC1Q4U7M

AI3-09055

alpha-Amino-beta-(4-hydroxyphenyl)propionic acid

AR-1J3457

BB_NC-1194

Benzenepropanoate

Benzenepropanoic acid

beta-(p-Hydroxyphenyl)alanine

bmse000051

C00082

CHEBI:17895

CHEMBL925

CID6057

D00022

DB00135

DB03839

DD69927C-C6A8-4BC6-8E9A-0AB423B176E7

DTY

EINECS 200-460-4

FEMA No. 3736

Free-Form L-Tyrosine

HSDB 2003

H-Tyr-OH

L Tyrosine

L-(-)-Tyrosine

L-2-Amino-3-p-hydroxyphenylpropanoic acid

L-p-Tyrosine

L-P-Tyrosine

LS-2336

L-Tyrosin

L-tyrosine

L-Tyrosine (9CI)

L-Tyrosine (JAN)

L-Tyrosine hydrochloride

L-Tyrosine, homopolymer

L-Tyrosine, monomer

Melanin synthesized from Tyr substrate catalyzed by tyrosinase for 6 hrs

Melanin synthesized from Tyr substrate catalyzed by tyrosinase for 6 hrs, oxidized with hydrogen peroxide

Melanin synthesized from Tyr substrate catalyzed by tyrosinase for 6 hrs, oxidized with hydrogen peroxide, <3 kd fraction

Melanin synthesized from Tyr substrate catalyzed by tyrosinase, brominated with N-bromosuccinimide

Melanin synthesized from Tyr substrate catalyzed by tyrosinase, sulfonated using sulfur trioxide/DMF complex for 1.5-7 hours

MolPort-001-792-016

NCGC00159350-02

NCGC00159350-03

nchembio.105-comp1

nchembio.121-comp7

nchembio.186-comp84

nchembio.284-comp7

nchembio816-comp11

NSC 82624

Para tyrosine

Para-tyrosine

p-Tyrosine

P-Tyrosine

Rxosine

T0550

T3754_SIAL

T4321_SIAL

T4321_SIGMA

T8566_SIGMA

tirosina

Tirosina

Tirosina [Spanish]

tyr

Tyr

TYR NH3+ COOH

tyrosine

Tyrosine

TYROSINE

Tyrosine (USP/INN)

Tyrosine (VAN)

Tyrosine [USAN:INN]

Tyrosine Power

Tyrosine, L- (8CI)

Tyrosine, L isomer

Tyrosine, L-isomer

Tyrosinum

Tyrosinum [Latin]

UNII-42HK56048U

W373605_ALDRICH

Crizotinib

Approved

Phase 2

877399-52-5

11626560 10366136 10366137 10366138 10366139 10366140 10366141

Ceritinib

Approved

Phase 2

1032900-25-6

Protein Kinase Inhibitors

Phase 2

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Targeted Therapy in Children and Adolescents With Recurrent, Progressive and Unresectable Inflammatory Myofibroblastic Tumor With the Inhibitor of Tyrosine Kinase -Crizotinib	Recruiting	NCT03874273	Phase 2, Phase 3	Crizotinib
2	A Phase 1/2, Open-Label, Safety, Tolerability, Pharmacokinetics, and Anti-Tumor Activity Study of Repotrectinib in Pediatric and Young Adult Subjects With Advanced or Metastatic Malignancies Harboring ALK, ROS1, NTRK1-3 Alterations	Recruiting	NCT04094610	Phase 1, Phase 2	Oral repotrectinib (TPX-0005)
3	Cross-tumoral Phase 2 Clinical Trial Exploring Crizotinib (PF-02341066) in Patients With Advanced Tumors Induced by Causal Alterations of ALK and/or MET ("CREATE")	Active, not recruiting	NCT01524926	Phase 2	Crizotinib (PF-02341066)
4	AcSé CRIZOTINIB : Secured Access to Crizotinib for Patients With Tumors Harboring a Genomic Alteration on One of the Biological Targets of the Drug.	Active, not recruiting	NCT02034981	Phase 2	Crizotinib
5	A Phase II, Open Label, Multi-center, Multi-arm Study of Ceritinib in Patients With Advanced Solid Tumors and Hematological Malignancies Characterized by Genetic Abnormalities of Anaplastic Lymphoma Kinase (ALK)	Terminated	NCT02465528	Phase 2	Ceritinib (LDK378)
6	An Open-Label, Phase 1/2 Dose Escalation and Expansion Trial to Evaluate the Pharmacokinetics, Safety, and Efficacy of Brigatinib as Monotherapy in Pediatric and Young Adult Patients With ALK+ Anaplastic Large Cell Lymphoma, Inflammatory Myofibroblastic Tumors or Other Solid Tumors	Withdrawn	NCT04260009	Phase 1, Phase 2	Brigatinib;Brigatinib AAF
7	A Phase I, Open-label, Dose Escalation Study of LDK378 in Pediatric Patients With Malignancies That Have a Genetic Alteration in Anaplastic Lymphoma Kinase (ALK)	Completed	NCT01742286	Phase 1	Ceritinib

Search NIH Clinical Center for Inflammatory Myofibroblastic Tumor

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Genetic Tests for Inflammatory Myofibroblastic Tumor

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Anatomical Context for Inflammatory Myofibroblastic Tumor

MalaCards organs/tissues related to Inflammatory Myofibroblastic Tumor:

⁴⁰

Lung, Liver, Eye, Bone, Breast, Kidney, Spleen

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Publications for Inflammatory Myofibroblastic Tumor

Articles related to Inflammatory Myofibroblastic Tumor:

(show top 50) (show all 1205)

#	Title	Authors	PMID	Year
1	Rare presentation of inflammatory myofibroblastic tumor in the kidney. ⁶¹	Abduljawad H...Ibrahim W	32577144	2020
2	Paraneoplastic opsoclonus myoclonus syndrome associated with inflammatory myofibroblastic tumor in a pediatric patient. ⁶¹	Gerstle K...Cohn SL	32472953	2020
3	Aggressive pelvic angiomyxoma and its mimics: can imaging be the guiding light? ⁶¹	Kumar N...Bansal VK	32401545	2020
4	Prolapsing inflammatory myofibroblastic tumor of the urinary bladder: A case report and a review of literature. ⁶¹	Higazy A...Kandel M	32300533	2020
5	How long should we continue crizotinib in ALK translocation-positive inflammatory myofibroblastic tumors? Long-term complete response with crizotinib and review of the literature. ⁶¹	Alan O...Yumuk PF	31615346	2020
6	A Novel ALK-THBS1 Fusion in a Laryngeal Inflammatory Myofibroblastic Tumour: A Case Report and Literature Review. ⁶¹	Elktaibi A...Costes Martineau V	31368077	2020
7	[Inflammatory myofibroblastic tumor with osteoclast-like giant cells of the nasopharynx: report of a case]. ⁶¹	Tao JX...Sun LB	32486552	2020
8	Successful treatment of pulmonary inflammatory myofibroblastic tumor with platinum-pemetrexed: The first report of two cases. ⁶¹	Si X...Zhang L	32495499	2020
9	Inflammatory Myofibroblastic Tumor of the Uterus: An Immunohistochemical Study of 23 Cases. ⁶¹	Bennett JA...Oliva E	32568825	2020
10	Inflammatory myofibroblastic tumor of maxillary sinus successfully treated with radiotherapy and corticosteroid: report of a rare case. ⁶¹	Biswas R...Biswas D	32488371	2020
11	Inflammatory Myofibroblastic Tumor of the Urinary System on Computed Tomography at a High-Volume Institution in China. ⁶¹	Chen B...Wei Q	32526751	2020
12	ALK-1-positive inflammatory myofibroblastic tumor of the thyroid complicated by Hashimoto's thyroiditis: report of a rare case and a literature review. ⁶¹	Li CF...Zheng H	32430041	2020
13	Inflammatory Myofibroblastic Tumor of the Orbit in an 8-Month Old. ⁶¹	Dermarkarian CR...Allen RC	31880682	2020
14	Inflammatory myofibroblastic tumor in the head and neck-a neoplasm with both tumor features and inflammation. ⁶¹	Zhang Y...Ji T	32414698	2020
15	[Clinical and pathological analysis of 64 patients with primary neoplasms of the lacrimal drainage system]. ⁶¹	Zhao Y...Pan Y	32450669	2020
16	Spontaneous pneumothorax caused by an inflammatory myofibroblastic tumor-like lesion in a 14-year-old girl: a case report. ⁶¹	Miyagi H...Miyamoto K	32448976	2020
17	Inflammatory Myofibroblastic Tumor of Spinal Canal: Brief Case Report. ⁶¹	Bryl M...Jaskolski DJ	31962352	2020
18	Pediatric airway tumors: A report from the International Network of Pediatric Airway Teams (INPAT). ⁶¹	Pio L...Torre M	31090942	2020
19	ALK 1 Negative Inflammatory Myofibroblastic Tumor of the Ileum: A Rare Cause of Ileocecal Intussusception. ⁶¹	Yagnik VD	32440556	2020
20	Inflammatory Myofibroblastic Tumor: Findings on 68Ga-DOTA-NOC Positron-emission Tomography-Computed Tomography. ⁶¹	Tripathy S...Prakash S	32351276	2020
21	Uterine inflammatory myofibroblastic tumor involving the decidua of the extraplacental membranes: report of a case with a TIMP3-ROS1 gene fusion. ⁶¹	Schoolmeester JK...Clayton AC	32247788	2020
22	Uterine Inflammatory Myofibroblastic Tumor Showing an Atypical ALK Signal Pattern by FISH and DES-ALK Fusion by RNA Sequencing: A Case Report. ⁶¹	Zarei S...Policarpio-Nicolas MLC	30741845	2020
23	Over expression of CDK4 and MDM2 in a patient with recurrent ALK-negative mediastinal inflammatory myofibroblastic tumor: A case report. ⁶¹	Hou TC...Su YW	32195970	2020
24	Carinal Resection and Reconstruction for an Obstructing Inflammatory Myofibroblastic Tumor in a Child. ⁶¹	Nawalaniec J...Murthy R	31117919	2020
25	Inflammatory myofibroblastic tumor: The experience of the European pediatric Soft Tissue Sarcoma Study Group (EpSSG). ⁶¹	Casanova M...Ferrari A	32007712	2020
26	Soft Tissue Special Issue: Fibroblastic and Myofibroblastic Neoplasms of the Head and Neck. ⁶¹	Baranov E...Hornick JL	31950474	2020
27	Isolated Pure Malignant Rhabdoid Tumor (MRT) of the Bladder: Case Report and Lessons Learned. ⁶¹	Hecht SL...Cost NG	31733273	2020
28	Acute Intestinal Obstruction Due to Ileocolic Intussusception in an Adult; A Rare Presentation of Inflammatory Myofibroblastic Tumor. ⁶¹	Hameed T...Sawant G	32102989	2020
29	Twenty children with non-Wilms renal tumors from a reference center in Central Anatolia, Turkey ⁶¹	Unal E...Patiroglu T	31655501	2020
30	Aggressive Inflammatory Myofibroblastic Tumor without Anaplastic Lymphoma Kinase Gene Rearrangement in the Rectum with Liver Metastasis. ⁶¹	Shimodaira Y...Iijima K	31588090	2020
31	Unusual subcutaneous dedifferentiated liposarcoma exhibiting coexistence of meningothelial-like whorls and inflammatory myofibroblastic tumor-like structures. ⁶¹	Chen S...Zhang R	31782160	2020
32	Inflammatory Myofibroblastic Tumors in the Uterus: Childhood-Case Report and Review of the Literature. ⁶¹	Etlinger P...Kovacs T	32117841	2020
33	Inflammatory myofibroblastic tumor of the spermatic cord: two cases and review of the literature. ⁶¹	Aydemir H...Kumsar S	32027518	2020
34	An Inflammatory Myofibroblastic Tumor of the Appendix Mimicking an Appendicular Malignant Lesion. ⁶¹	Gonzalez-Urquijo M...Gil-Galindo G	32118204	2020
35	Core Biopsy Diagnosis of ALK Positive Inflammatory Myofibroblastic Tumor of Lung: An Interesting Case. ⁶¹	Sachdev R...Sharma N	30632123	2020
36	Cancer Stem-Like Cells in a Case of an Inflammatory Myofibroblastic Tumor of the Lung. ⁶¹	Masciale V...Aramini B	32500024	2020
37	Gastric inflammatory myofibroblastic tumor in a 10-month-old girl: A case report. ⁶¹	Morales Prillwitz O...Astudillo Palomino RE	32172194	2020
38	Inflammatory myofibroblastic tumor of the spermatic cord: two cases and review of the literature. ⁶¹	Aydemir H...Kumsar S	32026712	2020
39	Simultaneous multiple primary cancers with concomitant inflammatory myofibroblastic tumor: a case report. ⁶¹	Lv X...Wang Y	32509097	2020
40	A Rare Case of Inflammatory Myofibroblastic Tumor Causing Left Pulmonary Artery Stenosis and Successfully Treated with Localized Radiotherapy in a Patient with Perinuclear Antineutrophil Cytoplasmic Antibody Vasculitis. ⁶¹	Browne CP...Joseph M	32104634	2020
41	Pituitary inflammatory pseudotumor with amenorrhea, polyuria, and impaired vision: case report and review of the literature. ⁶¹	Du Y...Jiang Z	32355527	2020
42	Rosai-Dorfman Disease of the Breast With Variable IgG4+ Plasma Cells: A Diagnostic Mimicker of Other Malignant and Reactive Entities. ⁶¹	Hoffmann JC...Ohgami RS	31436555	2019
43	Practical approach to diagnosis of bland-looking spindle cell lesions of the breast. ⁶¹	Magro G...Vecchio GM	31965112	2019
44	[A Case of Laparoscopic Local Resection of the Stomach for an Inflammatory Myofibroblastic Tumor]. ⁶¹	Uno H...Komatsu T	32157057	2019
45	[Canceration of inflammatory myofibroblastic tumor of the larynx:a case report]. ⁶¹	Wang YB...Liu CB	31914279	2019
46	IgG4-related Disease at Rectovesical Pouch Mimicking Inflammatory Myofibroblastic Tumor. ⁶¹	Chakrabarti S...Nada R	31884443	2019
47	Successful role of adjuvant radiotherapy in a rare case of tracheal inflammatory myofibroblastic tumor: a case report. ⁶¹	Lisi R...Tombolini V	30900517	2019
48	Anaplastic lymphoma kinase-negative pulmonary inflammatory myofibroblastic tumor with multiple metastases and its treatment by Apatinib: A case report. ⁶¹	Liu Q...Wang J	31876714	2019
49	Partial Response to Ceritinib in a Patient With Abdominal Inflammatory Myofibroblastic Tumor Carrying a TFG-ROS1 Fusion. ⁶¹	Li Y...Zhang HB	31805529	2019
50	Kidney inflammatory myofibroblastic tumor masquerading as metastatic malignancy: A case report and literature review. ⁶¹	Zhang GH...Wang Q	31911920	2019

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Genes for Inflammatory Myofibroblastic Tumor

Genes related to Inflammatory Myofibroblastic Tumor (6 elite genes):

(show all 49)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	ALK	ALK Receptor Tyrosine Kinase	Protein Coding	367.89	Gene fusion ⁵⁸ DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
2	CARS1	Cysteinyl-TRNA Synthetase 1	Protein Coding	364.32	Gene fusion ⁵⁸ DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
3	RANBP2	RAN Binding Protein 2	Protein Coding	364.24	Gene fusion ⁵⁸ DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
4	TPM3	Tropomyosin 3	Protein Coding	363.72	Gene fusion ⁵⁸ DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
5	TPM4	Tropomyosin 4	Protein Coding	357.64	Gene fusion ⁵⁸ DISEASES inferred ¹⁵
6	CLTC	Clathrin Heavy Chain	Protein Coding	357.44	Gene fusion ⁵⁸ DISEASES inferred ¹⁵
7	RNF213	Ring Finger Protein 213	Protein Coding	21.58	DISEASES inferred ¹⁵ GeneCards inferred via : Publications Summaries (show sections)
8	SEC31A	SEC31 Homolog A, COPII Coat Complex Component	Protein Coding	15.13	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
9	EML4	EMAP Like 4	Protein Coding	14.05	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
10	KIT	KIT Proto-Oncogene, Receptor Tyrosine Kinase	Protein Coding	13.62	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
11	NPM1	Nucleophosmin 1	Protein Coding	13.56	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
12	CR2	Complement C3d Receptor 2	Protein Coding	12.91	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
13	CR1	Complement C3b/C4b Receptor 1 (Knops Blood Group)	Protein Coding	12.83	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
14	PPFIBP1	PPFIA Binding Protein 1	Protein Coding	12.41	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
15	MDM2	MDM2 Proto-Oncogene	Protein Coding	12.18	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
16	TP53	Tumor Protein P53	Protein Coding	11.74	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
17	VIM	Vimentin	Protein Coding	11.37	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
18	CDK4	Cyclin Dependent Kinase 4	Protein Coding	11.36	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
19	ACVRL1	Activin A Receptor Like Type 1	Protein Coding	11.24	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
20	ACTC1	Actin Alpha Cardiac Muscle 1	Protein Coding	11.07	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
21	CCND1	Cyclin D1	Protein Coding	10.97	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
22	ENO2	Enolase 2	Protein Coding	10.36	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
23	MYC	MYC Proto-Oncogene, BHLH Transcription Factor	Protein Coding	10.1	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
24	MUC1	Mucin 1, Cell Surface Associated	Protein Coding	9.37	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
25	MCL1	MCL1 Apoptosis Regulator, BCL2 Family Member	Protein Coding	9.35	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
26	FGF19	Fibroblast Growth Factor 19	Protein Coding	8.08	DISEASES inferred ¹⁵
27	CD34	CD34 Molecule	Protein Coding	7.52	DISEASES inferred ¹⁵
28	ROS1	ROS Proto-Oncogene 1, Receptor Tyrosine Kinase	Protein Coding	7.45	DISEASES inferred ¹⁵
29	TFG	Trafficking From ER To Golgi Regulator	Protein Coding	7.28	DISEASES inferred ¹⁵
30	CALD1	Caldesmon 1	Protein Coding	7.27	DISEASES inferred ¹⁵
31	ATIC	5-Aminoimidazole-4-Carboxamide Ribonucleotide Formyltransferase/IMP Cyclohydrolase	Protein Coding	7.15	DISEASES inferred ¹⁵
32	DES	Desmin	Protein Coding	7	GeneCards inferred via : Publications (show sections)
33	S100B	S100 Calcium Binding Protein B	Protein Coding	6.91	GeneCards inferred via : Publications (show sections)
34	NTRK3	Neurotrophic Receptor Tyrosine Kinase 3	Protein Coding	6.74	DISEASES inferred ¹⁵
35	CD68	CD68 Molecule	Protein Coding	6.71	DISEASES inferred ¹⁵
36	MKI67	Marker Of Proliferation Ki-67	Protein Coding	6.65	GeneCards inferred via : Publications (show sections)
37	ANO1	Anoctamin 1	Protein Coding	6.55	DISEASES inferred ¹⁵
38	FLG2	Filaggrin Family Member 2	Protein Coding	6.49	DISEASES inferred ¹⁵
39	BCL2	BCL2 Apoptosis Regulator	Protein Coding	6.45	GeneCards inferred via : Publications (show sections)
40	F13A1	Coagulation Factor XIII A Chain	Protein Coding	6.45	GeneCards inferred via : Publications (show sections)
41	ETV6	ETS Variant Transcription Factor 6	Protein Coding	6.41	DISEASES inferred ¹⁵
42	LTK	Leukocyte Receptor Tyrosine Kinase	Protein Coding	6.3	DISEASES inferred ¹⁵
43	EWSR1	EWS RNA Binding Protein 1	Protein Coding	6.29	DISEASES inferred ¹⁵
44	MYOG	Myogenin	Protein Coding	6.28	DISEASES inferred ¹⁵
45	TNFRSF8	TNF Receptor Superfamily Member 8	Protein Coding	6.25	DISEASES inferred ¹⁵
46	KIF5B	Kinesin Family Member 5B	Protein Coding	6.22	DISEASES inferred ¹⁵
47	NTRK1	Neurotrophic Receptor Tyrosine Kinase 1	Protein Coding	6.16	DISEASES inferred ¹⁵
48	BIRC5	Baculoviral IAP Repeat Containing 5	Protein Coding	6.1	GeneCards inferred via : Publications (show sections)
49	CASP3	Caspase 3	Protein Coding	6.1	GeneCards inferred via : Publications (show sections)

Sources

Variations for Inflammatory Myofibroblastic Tumor

Sources

Expression for Inflammatory Myofibroblastic Tumor

Search GEO for disease gene expression data for Inflammatory Myofibroblastic Tumor.

Sources

Pathways for Inflammatory Myofibroblastic Tumor

Pathways related to Inflammatory Myofibroblastic Tumor according to GeneCards Suite gene sharing:

(show all 18)

#	Super pathways	Score	Top Affiliating Genes
1	Endometrial cancer ³⁶ Show member pathways Acute myeloid leukemia ³⁶ Binding of TCF/LEF-CTNNB1 to target gene promoters ⁶⁵ Chronic myeloid leukemia ³⁶ Colorectal cancer ³⁶ Pancreatic cancer ³⁶ Prostate cancer ³⁶ Signal transduction PTEN pathway ²² Thyroid cancer ³⁶	12.71	TPM3 TP53 MDM2 KIT CDK4
2	Measles ³⁶ Show member pathways Epstein-Barr virus infection ³⁶ Influenza A ³⁶	12.63	VIM TP53 MDM2 CR2 CDK4
3	Glioma ³⁶ Show member pathways Endocrine resistance ³⁶ Melanoma ³⁶ Non-small cell lung cancer ³⁶ Signaling Pathways in Glioblastoma ¹	12.47	TP53 MDM2 EML4 CDK4 ALK
4	Cytoskeletal Signaling ⁴	12.21	VIM SEC31A EML4 CLTC ACTC1
5	DNA Damage ⁴	12.13	VIM TP53 NPM1 MDM2 CDK4
6	Pathways in cancer ³⁶	11.89	TPM3 TP53 MDM2 KIT EML4 CDK4
7	Hematopoietic cell lineage ³⁶	11.75	KIT CR2 CR1
8	Retinoblastoma (RB) in Cancer ¹	11.68	TP53 MDM2 CDK4
9	Cardiac muscle contraction ³⁶	11.66	TPM4 TPM3 ACTC1
10	Validated targets of C-MYC transcriptional activation ¹	11.59	TP53 NPM1 CDK4
11	Bladder cancer ³⁶ ¹	11.53	TP53 MDM2 CDK4
12	Proteolysis Putative SUMO-1 pathway ²² Show member pathways DNA damage Role of SUMO in p53 regulation ²²	11.37	TP53 RANBP2 MDM2
13	Integrated Cancer Pathway ¹	11.27	TP53 MDM2 CDK4
14	DNA damage_ATM/ATR regulation of G1/S checkpoint ²²	11.22	TP53 MDM2 CDK4
15	Crizotinib Pathway, Pharmacokinetics/Pharmacodynamics ⁶⁰	11.12	NPM1 EML4 ALK
16	Striated Muscle Contraction ⁶⁵ ¹	11.11	VIM TPM4 TPM3 ACTC1
17	Oncogene Induced Senescence ⁶⁵	10.84	TP53 MDM2 CDK4
18	Sumoylation by RanBP2 regulates transcriptional repression ¹	10.58	RANBP2 MDM2

Sources

GO Terms for Inflammatory Myofibroblastic Tumor

Cellular components related to Inflammatory Myofibroblastic Tumor according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cytoplasm	GO:0005737	10.2	VIM TPM4 TPM3 TP53 SEC31A RNF213
2	protein-containing complex	GO:0032991	9.85	TP53 NPM1 MDM2 CLTC CDK4 ALK
3	cytosol	GO:0005829	9.8	VIM TPM4 TPM3 TP53 SEC31A RNF213
4	cytoskeleton	GO:0005856	9.76	VIM TPM4 TPM3 TP53 NPM1 EML4
5	receptor complex	GO:0043235	9.71	KIT CR2 ALK ACVRL1
6	actin filament	GO:0005884	9.61	TPM4 TPM3 ACTC1
7	muscle thin filament tropomyosin	GO:0005862	9.26	TPM4 TPM3
8	focal adhesion	GO:0005925	9.1	VIM TPM4 PPFIBP1 NPM1 CLTC ACTC1

Biological processes related to Inflammatory Myofibroblastic Tumor according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of gene expression	GO:0010628	9.77	VIM TP53 MDM2 KIT ACTC1
2	regulation of cell proliferation	GO:0042127	9.62	TP53 KIT CDK4 ALK
3	positive regulation of translation	GO:0045727	9.58	VIM NPM1 CDK4
4	viral process	GO:0016032	9.5	VIM TP53 RANBP2 NPM1 MDM2 CR2
5	cardiac septum morphogenesis	GO:0060411	9.46	TP53 MDM2
6	complement receptor mediated signaling pathway	GO:0002430	9.43	CR2 CR1
7	cellular response to UV-C	GO:0071494	9.26	TP53 MDM2
8	cellular response to actinomycin D	GO:0072717	9.16	TP53 MDM2
9	muscle filament sliding	GO:0030049	8.92	VIM TPM4 TPM3 ACTC1

Molecular functions related to Inflammatory Myofibroblastic Tumor according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	disordered domain specific binding	GO:0097718	8.8	TP53 MDM2 CLTC

Sources

Sources for Inflammatory Myofibroblastic Tumor

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NIH Rare Diseases

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia