Inflammatory Myofibroblastic Tumor disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: INF058 MIFTS: 45	Inflammatory Myofibroblastic Tumor Categories: Cancer diseases, Rare diseases, Respiratory diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs Expand all tables

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Aliases & Classifications for Inflammatory Myofibroblastic Tumor

MalaCards integrated aliases for Inflammatory Myofibroblastic Tumor:

Name: Inflammatory Myofibroblastic Tumor ¹² ²⁰ ⁵⁸ ¹⁵ ⁷⁰

Inflammatory Fibrosarcoma ²⁰

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases
Anatomical: Respiratory diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0050905

UMLS via Orphanet ⁷¹ C0334121

Orphanet ⁵⁸ ORPHA178342

UMLS ⁷⁰ C0334121

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Summaries for Inflammatory Myofibroblastic Tumor

GARD : ²⁰ An inflammatory myofibroblastic tumor (IMT) is an uncommon, usually benign (non-cancerous) tumor made up of cells called myofibroblastic spindle cells. It usually develops in children or young adults, but can affect people of any age. An IMT can occur in almost any part of the body but is most commonly found in the lung, orbit (eye socket), peritoneum (lining of the abdominal cavity and internal organs ), and mesentery. Signs and symptoms vary depending on the site of the tumor. Some people with an IMT are asymptomatic, while others may have nonspecific respiratory symptoms, fever, or pain. IMTs may recur, and become locally invasive and/or spread ( metastasize ) to other parts of the body. However, malignant (cancerous) IMTs are rare. The underlying cause of IMTs is poorly understood. Some cases have been linked to translocations involving the ALK gene. Treatment involves surgical removal when possible, although there are reports of treatment with oral steroids and radiation therapy.

MalaCards based summary : Inflammatory Myofibroblastic Tumor, also known as inflammatory fibrosarcoma, is related to epithelioid inflammatory myofibroblastic sarcoma and rare tumor, and has symptoms including fever and pain. An important gene associated with Inflammatory Myofibroblastic Tumor is ALK (ALK Receptor Tyrosine Kinase), and among its related pathways/superpathways are Endometrial cancer and Measles. The drugs Crizotinib and Tyrosine have been mentioned in the context of this disorder. Affiliated tissues include eye, breast and kidney, and related phenotypes are Decreased cell migration and Decreased cell migration

Disease Ontology : ¹² A mesenchymal cell neoplasm that has material basis in myofibroblastic cells admixed with inflammatory cells.

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Related Diseases for Inflammatory Myofibroblastic Tumor

Diseases related to Inflammatory Myofibroblastic Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 424)

#	Related Disease	Score	Top Affiliating Genes
1	epithelioid inflammatory myofibroblastic sarcoma	32.3	TPM4 TPM3 SEC31A RANBP2 ALK
2	rare tumor	32.0	KIT CR2 ACTC1
3	fasciitis	31.4	VIM TP53 ACTC1
4	fibrosarcoma	31.3	VIM TP53 KIT ALK ACTC1
5	fibrous histiocytoma	31.3	VIM KIT ALK ACTC1
6	pseudosarcomatous fibromatosis	31.3	VIM KIT ALK ACTC1
7	spindle cell sarcoma	31.3	VIM MDM2 KIT ACTC1
8	anaplastic large cell lymphoma	31.3	RNF213 NPM1 ALK ACVRL1
9	gastrointestinal stromal tumor	31.3	VIM TP53 KIT ACTC1
10	leiomyosarcoma	31.1	VIM TP53 MDM2 KIT CDK4 ACTC1
11	liposarcoma	31.1	VIM TP53 MDM2 CDK4
12	soft tissue sarcoma	31.1	TP53 MDM2
13	embryonal rhabdomyosarcoma	31.1	TP53 MDM2 CDK4
14	rhabdomyosarcoma	31.0	VIM TP53 MDM2 KIT CDK4 ALK
15	carcinosarcoma	31.0	VIM TP53 KIT ACTC1
16	retroperitoneal fibrosis	30.9	VIM MDM2
17	malignant fibrous histiocytoma	30.9	VIM TP53 MDM2 CDK4 ACTC1
18	dedifferentiated liposarcoma	30.9	TP53 MDM2 KIT CDK4 ACTC1
19	dendritic cell tumor	30.8	VIM CR2 CR1 ACTC1
20	smooth muscle tumor	30.8	VIM KIT CR2 ACTC1
21	sarcoma	30.8	VIM TP53 NPM1 MDM2 KIT CDK4
22	b-cell lymphoma	30.8	TP53 NPM1 MDM2 CR2 CDK4 ALK
23	adenocarcinoma	30.8	TP53 MDM2 KIT CDK4 ALK
24	endometrial stromal sarcoma	30.8	VIM TP53 KIT ACTC1
25	angiosarcoma	30.8	VIM TP53 MDM2 KIT
26	lymphoma	30.7	TP53 RNF213 NPM1 MDM2 EML4 CR2
27	alk-positive anaplastic large cell lymphoma	30.7	NPM1 ALK
28	inflammatory liposarcoma	30.7	MDM2 ALK
29	congenital fibrosarcoma	30.7	VIM TPM3 ALK ACTC1
30	castleman disease	30.6	CR2 CR1 ACVRL1
31	perineurioma	30.6	VIM KIT ALK ACTC1
32	cystitis	30.6	VIM TP53 KIT
33	ring chromosome	30.6	TP53 MDM2 CDK4
34	hemangiopericytoma, malignant	30.6	VIM MDM2 KIT ACTC1
35	neurofibroma	30.6	VIM TP53 KIT ACTC1
36	hemangioma	30.5	VIM TP53 KIT ACTC1
37	connective tissue benign neoplasm	30.5	TP53 MDM2 KIT CDK4
38	well-differentiated liposarcoma	30.5	TP53 MDM2 KIT CDK4
39	mesenchymal cell neoplasm	30.5	TPM4 TPM3 TP53 RANBP2 NPM1 KIT
40	diffuse large b-cell lymphoma	30.4	TP53 MDM2 CDK4 ALK
41	embryonal sarcoma	30.4	VIM TP53 MDM2 KIT CDK4
42	lymphoma, non-hodgkin, familial	30.4	TP53 NPM1 MDM2 CR2 ALK
43	malignant peripheral nerve sheath tumor	30.4	VIM TP53 MDM2 KIT CDK4 ACTC1
44	ewing sarcoma	30.4	VIM TP53 MDM2 KIT CDK4 ALK
45	neuroblastoma	30.3	TP53 NPM1 MDM2 KIT CDK4 ALK
46	liver inflammatory pseudotumor	11.3
47	infantile myofibromatosis	11.2
48	intussusception	10.6
49	lymphangiectasis	10.6	VIM ACTC1
50	intravascular papillary endothelial hyperplasia	10.6	VIM ACTC1

Graphical network of the top 20 diseases related to Inflammatory Myofibroblastic Tumor:

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Symptoms & Phenotypes for Inflammatory Myofibroblastic Tumor

UMLS symptoms related to Inflammatory Myofibroblastic Tumor:

fever; pain

GenomeRNAi Phenotypes related to Inflammatory Myofibroblastic Tumor according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased cell migration	GR00055-A-1	9.26	ALK CDK4 VIM
2	Decreased cell migration	GR00055-A-3	9.26	TPM4
3	Decreased substrate adherent cell growth	GR00193-A-1	9.23	ACVRL1 KIT
4	Decreased substrate adherent cell growth	GR00193-A-2	9.23	CDK4 KIT
5	Decreased substrate adherent cell growth	GR00193-A-3	9.23	CDK4
6	Decreased substrate adherent cell growth	GR00193-A-4	9.23	ACVRL1 CDK4 KIT

MGI Mouse Phenotypes related to Inflammatory Myofibroblastic Tumor:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	muscle	MP:0005369	9.56	ACTC1 ACVRL1 CDK4 KIT MDM2 TP53
2	normal	MP:0002873	9.28	ACTC1 ACVRL1 ALK CDK4 KIT MDM2

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Drugs & Therapeutics for Inflammatory Myofibroblastic Tumor

Drugs for Inflammatory Myofibroblastic Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Crizotinib

Approved

Phase 2, Phase 3

877399-52-5

11626560 10366136 10366137 10366138 10366139 10366140 10366141

Tyrosine

Approved, Investigational, Nutraceutical

Phase 2, Phase 3

60-18-4

6057

Synonyms:

(-)-a-Amino-p-hydroxyhydrocinnamate

(-)-a-Amino-p-hydroxyhydrocinnamic acid

(-)-alpha-Amino-p-hydroxyhydrocinnamate

(-)-alpha-Amino-p-hydroxyhydrocinnamic acid

(-)-Α-amino-p-hydroxyhydrocinnamate

(−)-α-amino-p-hydroxyhydrocinnamic acid

(-)-Α-amino-p-hydroxyhydrocinnamic acid

(2S)-2-Amino-3-(4-hydroxyphenyl)propanoate

(2S)-2-amino-3-(4-hydroxyphenyl)propanoic acid

(2S)-2-Amino-3-(4-hydroxyphenyl)propanoic acid

(S)-(-)-Tyrosine

(S)-2-Amino-3-(4-hydroxyphenyl)propionic acid

(S)-2-Amino-3-(p-hydroxyphenyl)propionate

(S)-2-Amino-3-(p-hydroxyphenyl)propionic acid

(S)-3-(p-Hydroxyphenyl)alanine

(S)-a-Amino-4-hydroxybenzenepropanoate

(S)-a-Amino-4-hydroxy-benzenepropanoate

(S)-a-Amino-4-hydroxybenzenepropanoic acid

(S)-a-Amino-4-hydroxy-benzenepropanoic acid

(S)-alpha-Amino-4-hydroxybenzenepropanoate

(S)-alpha-Amino-4-hydroxy-benzenepropanoate

(S)-alpha-amino-4-Hydroxybenzenepropanoic acid

(S)-alpha-Amino-4-hydroxybenzenepropanoic acid

(S)-alpha-Amino-4-hydroxy-benzenepropanoic acid

(S)-Tyrosine

(S)-Α-amino-4-hydroxybenzenepropanoate

(S)-α-amino-4-hydroxybenzenepropanoic acid

(S)-Α-amino-4-hydroxybenzenepropanoic acid

140-43-2

1991-85-1

25619-78-7

2-Amino-3-(4-hydroxyphen yl)-2-amino-3-(4-hydroxyphenyl)-propanoate

2-Amino-3-(4-hydroxyphen yl)-2-amino-3-(4-hydroxyphenyl)-propanoic acid

2-Amino-3-(p-hydroxyphenyl)propionic acid

2csm

3-(4-Hydroxyphenyl)-L-alanine

3-(p-Hydroxyphenyl)alanine

46209-14-7

4-hydroxy-L-phenylalanine

4-Hydroxy-L-phenylalanine

4ts1

55520-40-6

60-18-4

93829_FLUKA

93829_SIGMA

AB1002647

AC-11295

AC1L1LPI

AC1Q4U7L

AC1Q4U7M

AI3-09055

alpha-Amino-beta-(4-hydroxyphenyl)propionic acid

AR-1J3457

BB_NC-1194

Benzenepropanoate

Benzenepropanoic acid

beta-(p-Hydroxyphenyl)alanine

bmse000051

C00082

CHEBI:17895

CHEMBL925

CID6057

D00022

DB00135

DB03839

DD69927C-C6A8-4BC6-8E9A-0AB423B176E7

DTY

EINECS 200-460-4

FEMA No. 3736

Free-Form L-Tyrosine

HSDB 2003

H-Tyr-OH

L Tyrosine

L-(-)-Tyrosine

L-2-Amino-3-p-hydroxyphenylpropanoic acid

L-p-Tyrosine

LS-2336

L-Tyrosin

L-tyrosine

L-Tyrosine (9CI)

L-Tyrosine (JAN)

L-Tyrosine hydrochloride

L-Tyrosine, homopolymer

L-Tyrosine, monomer

Melanin synthesized from Tyr substrate catalyzed by tyrosinase for 6 hrs

Melanin synthesized from Tyr substrate catalyzed by tyrosinase for 6 hrs, oxidized with hydrogen peroxide

Melanin synthesized from Tyr substrate catalyzed by tyrosinase for 6 hrs, oxidized with hydrogen peroxide, <3 kd fraction

Melanin synthesized from Tyr substrate catalyzed by tyrosinase, brominated with N-bromosuccinimide

Melanin synthesized from Tyr substrate catalyzed by tyrosinase, sulfonated using sulfur trioxide/DMF complex for 1.5-7 hours

MolPort-001-792-016

NCGC00159350-02

NCGC00159350-03

nchembio.105-comp1

nchembio.121-comp7

nchembio.186-comp84

nchembio.284-comp7

nchembio816-comp11

NSC 82624

Para tyrosine

Para-tyrosine

p-Tyrosine

Rxosine

T0550

T3754_SIAL

T4321_SIAL

T4321_SIGMA

T8566_SIGMA

tirosina

Tirosina

Tirosina [Spanish]

tyr

Tyr

TYR NH3+ COOH

tyrosine

Tyrosine

TYROSINE

Tyrosine (USP/INN)

Tyrosine (VAN)

Tyrosine [USAN:INN]

Tyrosine Power

Tyrosine, L- (8CI)

Tyrosine, L isomer

Tyrosine, L-isomer

Tyrosinum

Tyrosinum [Latin]

UNII-42HK56048U

W373605_ALDRICH

Ceritinib

Approved

Phase 2

1032900-25-6

Protein Kinase Inhibitors

Phase 2

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Targeted Therapy in Children and Adolescents With Recurrent, Progressive and Unresectable Inflammatory Myofibroblastic Tumor With the Inhibitor of Tyrosine Kinase -Crizotinib	Unknown status	NCT03874273	Phase 2, Phase 3	Crizotinib
2	A Phase 1/2, Open-Label, Safety, Tolerability, Pharmacokinetics, and Anti-Tumor Activity Study of Repotrectinib in Pediatric and Young Adult Subjects With Advanced or Metastatic Malignancies Harboring ALK, ROS1, NTRK1-3 Alterations	Recruiting	NCT04094610	Phase 1, Phase 2	Oral repotrectinib (TPX-0005)
3	A Phase II, Open Label, Multi-center, Multi-arm Study of Ceritinib in Patients With Advanced Solid Tumors and Hematological Malignancies Characterized by Genetic Abnormalities of Anaplastic Lymphoma Kinase (ALK)	Terminated	NCT02465528	Phase 2	Ceritinib (LDK378)
4	An Open-Label, Phase 1/2 Dose Escalation and Expansion Trial to Evaluate the Pharmacokinetics, Safety, and Efficacy of Brigatinib as Monotherapy in Pediatric and Young Adult Patients With ALK+ Anaplastic Large Cell Lymphoma, Inflammatory Myofibroblastic Tumors or Other Solid Tumors	Withdrawn	NCT04260009	Phase 1, Phase 2	Brigatinib;Brigatinib AAF
5	A Phase I, Open-label, Dose Escalation Study of LDK378 in Pediatric Patients With Malignancies That Have a Genetic Alteration in Anaplastic Lymphoma Kinase (ALK)	Completed	NCT01742286	Phase 1	Ceritinib
6	Study on the Molecular Profile and Molecular Signature of Inflammatory Myofibroblastic Tumor	Recruiting	NCT04572594

Search NIH Clinical Center for Inflammatory Myofibroblastic Tumor

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Genetic Tests for Inflammatory Myofibroblastic Tumor

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Anatomical Context for Inflammatory Myofibroblastic Tumor

MalaCards organs/tissues related to Inflammatory Myofibroblastic Tumor:

⁴⁰

Eye, Breast, Kidney, Spleen, Pancreas, Uterus, Trachea

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Publications for Inflammatory Myofibroblastic Tumor

Articles related to Inflammatory Myofibroblastic Tumor:

(show top 50) (show all 1286)

#	Title	Authors	PMID	Year
1	Renal inflammatory myofibroblastic tumor: A case report. ⁶¹	Ivanov AS...Chitalov ZR	33732621	2021
2	A rare case of urachal inflammatory myofibroblastic tumor. ⁶¹	George R...Mian BM	33537209	2021
3	Inflammatory Myofibroblastic Tumor Presenting as Gross Hematuria in a Pediatric Patient With VACTERL Syndrome Following Bladder Augmentation. ⁶¹	Chandora A...Smith EA	33684396	2021
4	Rare Presentation of Inflammatory Myofibroblastic Tumor on a Digit. ⁶¹	West CE...Hosler GA	33754372	2021
5	Sustained complete response on crizotinib in primary lung inflammatory myofibroblastic tumor - Case report and literature review. ⁶¹	Mittal A...Rastogi S	33794589	2021
6	[Clinicopathological features of inflammatory myofibroblastic tumor]. ⁶¹	Zhu Y...Gong QX	33677881	2021
7	[Inflammatory myofibroblastic tumor: report of rare cases with a specific immunophenotype]. ⁶¹	Ke ZY...Yang SJ	33677890	2021
8	Colonic Inflammatory Myofibroblastic Tumor. ⁶¹	Wang Y...Pan Y	32632730	2021
9	Recurrent infantile inflammatory myofibroblastic tumor of mesentery--Case report and review of imaging findings. ⁶¹	Gupta A...Rastogi S	33363692	2021
10	Inflammatory Myofibroblastic Tumor After Treatment of Wilms Tumor in a 6-Year-Old Boy: A Case Report and Literature Review. ⁶¹	Li YP...Zhang WP	33221418	2021
11	[Dacryocyst inflammatory myofibroblastic tumor: a case report]. ⁶¹	Wang A...Zhao CQ	33730814	2021
12	Algorithmic Approach to Fibroinflammatory Sinonasal Tract Lesions. ⁶¹	Thompson LDR	33723762	2021
13	Safety and Antitumor Activity of Repeated ASP3026 Administration in Japanese Patients with Solid Tumors: A Phase I Study. ⁶¹	Ono A...Nakagawa K	33331996	2021
14	Benign skull and subdural lesions in patients with prior medulloblastoma therapy. ⁶¹	Kaneva K...Aw-Zoretic J	32876801	2021
15	Mimickers of Urothelial Carcinoma and the Approach to Differential Diagnosis. ⁶¹	Manini C...Lopez JI	33668963	2021
16	A novel LRRFIP1-ALK fusion in inflammatory myofibroblastic tumor of hip and response to crizotinib. ⁶¹	Liu W...Niu X	32915420	2021
17	[Treatment of ALK negative metastatic inflammatory myofibroblastic tumor by combination of pembrolizumab and anlotinib: a case report]. ⁶¹	Li XS...Shen WZ	33601493	2021
18	Intracranial inflammatory myofibroblastic tumor: a report of two cases. ⁶¹	Wang G...Zhang L	33517794	2021
19	Pseudosarcomatous myofibroblastic proliferations of the urinary bladder are neoplasms characterized by recurrent FN1-ALK fusions. ⁶¹	Acosta AM...Jo VY	32908253	2021
20	ALK Immunohistochemistry and Molecular Analysis in Uterine Inflammatory Myofibroblastic Tumor: Proceedings of the ISGyP Companion Society Session at the 2020 USCAP Annual Meeting. ⁶¹	Parra-Herran C	33290353	2021
21	A Conservative Approach to Inflammatory Myofibroblastic Tumor of the Bladder: A Case Report and Review of Literature. ⁶¹	Abou Zahr R...Roumeguere T	33763285	2021
22	Inflammatory myofibroblastic tumor of the urinary bladder: A prognostically favorable spindle cell neoplasm. ⁶¹	Laylo JCV...Remo JJV	33194556	2021
23	[Casuistics of inflammatory myofibroblastic tumor in a tertiary center]. ⁶¹	Martinez Navarro G...Fernandez Navarro JM	33495091	2021
24	Inflammatory myofibroblastic tumor successfully treated with metformin: A case report and review of literature. ⁶¹	Liang Y...Gu S	33521112	2021
25	Clinical characteristics and outcomes of 17 cases of inflammatory myofibroblastic tumor at a University Hospital in China. ⁶¹	Song W...Zhu Y	33281962	2021
26	Recurrent pulmonary embolization of inflammatory myofibroblastic tumor: a case report. ⁶¹	Ponzoni M...Padalino MA	32858207	2021
27	Common Variable Immunodeficiency with the Concomitant Diagnosis of an Inflammatory Myofibroblastic Tumor. ⁶¹	Sewell C...Hostoffer R	33017039	2021
28	Rechallenge with Multi-Targeted Tyrosine Kinase Inhibitors in Patients with Advanced Soft Tissue Sarcoma: A Single-Center Experience. ⁶¹	Liu J...Jiang Y	33776477	2021
29	Inflammatory Myofibroblastic Tumor of the Liver Mimicking Metastasis on 18F-FDG PET/CT. ⁶¹	Raad RA...El-Rassi Z	33156048	2021
30	MR imaging findings of unusual leiomyoma and malignant uterine myometrial tumors: what the radiologist should know. ⁶¹	Fujii S...Ishibashi M	33517507	2021
31	Diagnostic Challenge of Sarcomatoid Variant of ALK-Positive Anaplastic Large Cell Lymphoma: Case Report and Updated Systematic Literature Review. ⁶¹	Song F...Sun PL	33427000	2021
32	Sinonasal IgG4-related disease: a rare and emerging entity broadening the differential diagnosis in the sinonasal universe. ⁶¹	Kaur K...Bhalla AS	33392765	2021
33	Management of bladder tumors in pregnancy: A case of tumor prolapse and avulsion during labor. ⁶¹	Hanson KA...Warlick CA	33304822	2021
34	Prevalence, clinical features and prognosis of malignant solid tumors in infants: a 14-year study. ⁶¹	Zhi T...Huang DS	33259778	2020
35	Inflammatory myofibroblastic tumor of ileum with intussusception in adult. ⁶¹	Hirose S...Mizokami Y	32651869	2020
36	Inflammatory Myofibroblastic Tumor of the Bladder With FN1-ALK Gene Fusion: Different Response to ALK Inhibition. ⁶¹	Reinhart S...Pless M	33007314	2020
37	[Pinnal inflammatory myofibroblastic tumor: a case report]. ⁶¹	Yan RC...Fan SC	33342136	2020
38	Cardiac Inflammatory Myofibroblastic Tumor Causing Pulmonary Artery Obstruction: A Rare Case Report. ⁶¹	Yildiz K...Ozer E	33273411	2020
39	Inflammatory myofibroblastic tumor in the head and neck-a neoplasm with both tumor features and inflammation. ⁶¹	Zhang Y...Ji T	32414698	2020
40	Inflammatory Myofibroblastic Tumor of the Urinary Bladder and Ureter in Children: Experience of a Tertiary Referral Center. ⁶¹	Li YP...Zhang WP	32777366	2020
41	Inflammatory Myofibroblastic Tumor of the Uterus: An Immunohistochemical Study of 23 Cases. ⁶¹	Bennett JA...Oliva E	32568825	2020
42	Inflammatory Myofibroblastic Tumor of Sigmoid Colon: Unusual Cause of Intestinal Obstruction. ⁶¹	Chinnakkulam Kandhasamy S...Nelamangala Ramakrishnaiah VP	33409054	2020
43	Local ALK-Positive Histiocytosis With Unusual Morphology and Novel TRIM33-ALK Gene Fusion. ⁶¹	Tran TAN...Chang CC	33243034	2020
44	Primary Pulmonary Tumors in Pediatric Population: Imaging Markers for Predicting Histology. ⁶¹	Dawani A...Naranje P	33487938	2020
45	The Activity of Chemotherapy in Inflammatory Myofibroblastic Tumors: A Multicenter, European Retrospective Case Series Analysis. ⁶¹	Baldi GG...Stacchiotti S	32584482	2020
46	Inflammatory myofibroblastic tumor arising from soft tissues of extremities harboring a novel CLIP2-ALK fusion. ⁶¹	Ding R...Gong QX	32716129	2020
47	Infantile Inflammatory Myofibroblastic Tumor of Spleen. ⁶¹	Thirunavukkarasu B...Bansal D	33095087	2020
48	Adult Mid Ileo-Ileal Intussusception Secondary to Inflammatory Myofibroblastic Tumor (IMT): A Case Report and Literature Review. ⁶¹	Farhan M...Ali Z	33194470	2020
49	Clinical characteristics of resected solitary ground-glass opacities: Comparison between benign and malignant nodules. ⁶¹	Qin Y...Liu H	32844603	2020
50	A Case of Simultaneously Diagnosed Lung Adenocarcinoma and Endobronchial Inflammatory Myofibroblastic Tumor with Two Distinct Types of ALK Translocation. ⁶¹	Zhao S...Xu S	33091968	2020

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Genes for Inflammatory Myofibroblastic Tumor

Genes related to Inflammatory Myofibroblastic Tumor (6 elite genes):

(show all 48)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	ALK	ALK Receptor Tyrosine Kinase	Protein Coding	367.81	Gene fusion ⁵⁸ DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)	17063337
2	RANBP2	RAN Binding Protein 2	Protein Coding	365.15	Gene fusion ⁵⁸ DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)	12661011
3	TPM3	Tropomyosin 3	Protein Coding	364.75	Gene fusion ⁵⁸ DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)	17063337
4	CARS1	Cysteinyl-TRNA Synthetase 1	Protein Coding	363.76	Gene fusion ⁵⁸ DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)	13679433 12112524
5	TPM4	Tropomyosin 4	Protein Coding	357.59	Gene fusion ⁵⁸ DISEASES inferred ¹⁵	10934142
6	CLTC	Clathrin Heavy Chain	Protein Coding	357.37	Gene fusion ⁵⁸ DISEASES inferred ¹⁵	17656252
7	RNF213	Ring Finger Protein 213	Protein Coding	21.99	DISEASES inferred ¹⁵ GeneCards inferred via : Publications Summaries (show sections)
8	EML4	EMAP Like 4	Protein Coding	14.71	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
9	NPM1	Nucleophosmin 1	Protein Coding	14.23	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
10	SEC31A	SEC31 Homolog A, COPII Coat Complex Component	Protein Coding	14.09	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
11	KIT	KIT Proto-Oncogene, Receptor Tyrosine Kinase	Protein Coding	13.94	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
12	CR1	Complement C3b/C4b Receptor 1 (Knops Blood Group)	Protein Coding	13.6	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
13	CR2	Complement C3d Receptor 2	Protein Coding	13.55	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
14	PPFIBP1	PPFIA Binding Protein 1	Protein Coding	13.05	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
15	MDM2	MDM2 Proto-Oncogene	Protein Coding	12.81	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
16	TP53	Tumor Protein P53	Protein Coding	12.39	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
17	VIM	Vimentin	Protein Coding	12.02	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
18	CDK4	Cyclin Dependent Kinase 4	Protein Coding	12	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
19	ACVRL1	Activin A Receptor Like Type 1	Protein Coding	11.93	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
20	ACTC1	Actin Alpha Cardiac Muscle 1	Protein Coding	11.72	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
21	CCND1	Cyclin D1	Protein Coding	11.6	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
22	ENO2	Enolase 2	Protein Coding	11	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
23	MYC	MYC Proto-Oncogene, BHLH Transcription Factor	Protein Coding	10.76	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
24	MUC1	Mucin 1, Cell Surface Associated	Protein Coding	10.03	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
25	MCL1	MCL1 Apoptosis Regulator, BCL2 Family Member	Protein Coding	9.99	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
26	DES	Desmin	Protein Coding	7.7	GeneCards inferred via : Publications (show sections)
27	S100B	S100 Calcium Binding Protein B	Protein Coding	7.5	GeneCards inferred via : Publications (show sections)
28	ROS1	ROS Proto-Oncogene 1, Receptor Tyrosine Kinase	Protein Coding	7.49	DISEASES inferred ¹⁵
29	CD34	CD34 Molecule	Protein Coding	7.47	DISEASES inferred ¹⁵
30	MKI67	Marker Of Proliferation Ki-67	Protein Coding	7.36	GeneCards inferred via : Publications (show sections)
31	TFG	Trafficking From ER To Golgi Regulator	Protein Coding	7.22	DISEASES inferred ¹⁵
32	CALD1	Caldesmon 1	Protein Coding	7.21	DISEASES inferred ¹⁵
33	BCL2	BCL2 Apoptosis Regulator	Protein Coding	7.15	GeneCards inferred via : Publications (show sections)
34	ATIC	5-Aminoimidazole-4-Carboxamide Ribonucleotide Formyltransferase/IMP Cyclohydrolase	Protein Coding	7.1	DISEASES inferred ¹⁵
35	BIRC5	Baculoviral IAP Repeat Containing 5	Protein Coding	6.81	GeneCards inferred via : Publications (show sections)
36	CASP3	Caspase 3	Protein Coding	6.81	GeneCards inferred via : Publications (show sections)
37	CDKN1A	Cyclin Dependent Kinase Inhibitor 1A	Protein Coding	6.81	GeneCards inferred via : Publications (show sections)
38	CFLAR	CASP8 And FADD Like Apoptosis Regulator	Protein Coding	6.81	GeneCards inferred via : Publications (show sections)
39	F13A1	Coagulation Factor XIII A Chain	Protein Coding	6.81	GeneCards inferred via : Publications (show sections)
40	FCER2	Fc Fragment Of IgE Receptor II	Protein Coding	6.81	GeneCards inferred via : Publications (show sections)
41	HNRNPA1	Heterogeneous Nuclear Ribonucleoprotein A1	Protein Coding	6.81	GeneCards inferred via : Publications (show sections)
42	IFI27	Interferon Alpha Inducible Protein 27	Protein Coding	6.81	GeneCards inferred via : Publications (show sections)
43	RB1	RB Transcriptional Corepressor 1	Protein Coding	6.81	GeneCards inferred via : Publications (show sections)
44	S100A1	S100 Calcium Binding Protein A1	Protein Coding	6.81	GeneCards inferred via : Publications (show sections)
45	SYNM	Synemin	Protein Coding	6.81	GeneCards inferred via : Publications (show sections)
46	WDR48	WD Repeat Domain 48	Protein Coding	6.81	GeneCards inferred via : Publications (show sections)
47	NTRK3	Neurotrophic Receptor Tyrosine Kinase 3	Protein Coding	6.73	DISEASES inferred ¹⁵
48	CD68	CD68 Molecule	Protein Coding	6.66	DISEASES inferred ¹⁵

Sources

Variations for Inflammatory Myofibroblastic Tumor

Sources

Expression for Inflammatory Myofibroblastic Tumor

Search GEO for disease gene expression data for Inflammatory Myofibroblastic Tumor.

Sources

Pathways for Inflammatory Myofibroblastic Tumor

Pathways related to Inflammatory Myofibroblastic Tumor according to GeneCards Suite gene sharing:

(show all 18)

#	Super pathways	Score	Top Affiliating Genes
1	Endometrial cancer ³⁶ Show member pathways Acute myeloid leukemia ³⁶ Binding of TCF/LEF-CTNNB1 to target gene promoters ⁶⁵ Chronic myeloid leukemia ³⁶ Colorectal cancer ³⁶ Pancreatic cancer ³⁶ Prostate cancer ³⁶ Signal transduction PTEN pathway ²³ Thyroid cancer ³⁶	12.71	TPM3 TP53 MDM2 KIT CDK4
2	Measles ³⁶ Show member pathways Epstein-Barr virus infection ³⁶ Influenza A ³⁶	12.64	VIM TP53 MDM2 CR2 CDK4
3	Glioma ³⁶ Show member pathways Endocrine resistance ³⁶ Melanoma ³⁶ Non-small cell lung cancer ³⁶ Signaling Pathways in Glioblastoma ¹	12.48	TP53 MDM2 EML4 CDK4 ALK
4	Cytoskeletal Signaling ⁴	12.21	VIM SEC31A EML4 CLTC ACTC1
5	DNA Damage ⁴	12.13	VIM TP53 NPM1 MDM2 CDK4
6	Pathways in cancer ³⁶	11.89	TPM3 TP53 MDM2 KIT EML4 CDK4
7	Hematopoietic cell lineage ³⁶	11.75	KIT CR2 CR1
8	Retinoblastoma (RB) in Cancer ¹	11.68	TP53 MDM2 CDK4
9	Cardiac muscle contraction ³⁶	11.66	TPM4 TPM3 ACTC1
10	Validated targets of C-MYC transcriptional activation ¹	11.59	TP53 NPM1 CDK4
11	Bladder cancer ³⁶ ¹	11.53	TP53 MDM2 CDK4
12	Proteolysis Putative SUMO-1 pathway ²³ Show member pathways DNA damage Role of SUMO in p53 regulation ²³	11.37	TP53 RANBP2 MDM2
13	Integrated Cancer Pathway ¹	11.27	TP53 MDM2 CDK4
14	DNA damage_ATM/ATR regulation of G1/S checkpoint ²³	11.22	TP53 MDM2 CDK4
15	Crizotinib Pathway, Pharmacokinetics/Pharmacodynamics ⁶⁰	11.12	NPM1 EML4 ALK
16	Striated Muscle Contraction ⁶⁵ ¹	11.11	VIM TPM4 TPM3 ACTC1
17	Oncogene Induced Senescence ⁶⁵	10.84	TP53 MDM2 CDK4
18	Sumoylation by RanBP2 regulates transcriptional repression ¹	10.57	RANBP2 MDM2

Sources

GO Terms for Inflammatory Myofibroblastic Tumor

Cellular components related to Inflammatory Myofibroblastic Tumor according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	membrane	GO:0016020	10.34	VIM TPM4 TP53 SEC31A RNF213 RANBP2
2	cytoplasm	GO:0005737	10.2	VIM TPM4 TPM3 TP53 SEC31A RNF213
3	cytosol	GO:0005829	10	VIM TPM4 TPM3 TP53 SEC31A RNF213
4	protein-containing complex	GO:0032991	9.85	TP53 NPM1 MDM2 CLTC CDK4 ALK
5	receptor complex	GO:0043235	9.71	KIT CR2 ALK ACVRL1
6	actin filament	GO:0005884	9.63	TPM4 TPM3 ACTC1
7	focal adhesion	GO:0005925	9.43	VIM TPM4 PPFIBP1 NPM1 CLTC ACTC1
8	cytoskeleton	GO:0005856	9.28	VIM TPM4 TPM3 TP53 NPM1 EML4
9	muscle thin filament tropomyosin	GO:0005862	9.26	TPM4 TPM3

Biological processes related to Inflammatory Myofibroblastic Tumor according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of cell proliferation	GO:0008284	9.85	NPM1 MDM2 KIT CR1 CDK4
2	positive regulation of gene expression	GO:0010628	9.8	VIM TP53 MDM2 KIT ACTC1
3	regulation of cell proliferation	GO:0042127	9.62	TP53 KIT CDK4 ALK
4	positive regulation of translation	GO:0045727	9.54	VIM NPM1 CDK4
5	viral process	GO:0016032	9.5	VIM TP53 RANBP2 NPM1 MDM2 CR2
6	cardiac septum morphogenesis	GO:0060411	9.48	TP53 MDM2
7	complement receptor mediated signaling pathway	GO:0002430	9.43	CR2 CR1
8	cellular response to UV-C	GO:0071494	9.26	TP53 MDM2
9	cellular response to actinomycin D	GO:0072717	9.16	TP53 MDM2
10	muscle filament sliding	GO:0030049	8.92	VIM TPM4 TPM3 ACTC1

Molecular functions related to Inflammatory Myofibroblastic Tumor according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	disordered domain specific binding	GO:0097718	8.8	TP53 MDM2 CLTC

Sources

Sources for Inflammatory Myofibroblastic Tumor

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GARD

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MedlinePlus Genetics

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 05-Apr-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ Tocris

⁷⁰ UMLS

⁷¹ UMLS via Orphanet

⁷² UniProtKB/Swiss-Prot

⁷³ Wikipedia