MCID: INF058
MIFTS: 45
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Inflammatory Myofibroblastic Tumor
Categories:
Cancer diseases, Rare diseases
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MalaCards integrated aliases for Inflammatory Myofibroblastic Tumor:
Classifications:External Ids:
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NIH Rare Diseases :
52
An inflammatory myofibroblastic tumor (IMT) is an uncommon, usually benign (non-cancerous) tumor made up of cells called myofibroblastic spindle cells. It usually develops in children or young adults, but can affect people of any age. An IMT can occur in almost any part of the body but is most commonly found in the lung, orbit (eye socket), peritoneum (lining of the abdominal cavity and internal organs ), and mesentery . Signs and symptoms vary depending on the site of the tumor. Some people with an IMT are asymptomatic, while others may have nonspecific respiratory symptoms, fever, or pain. IMTs may recur, and become locally invasive and/or spread (metastasize ) to other parts of the body. However, malignant (cancerous) IMTs are rare. The underlying cause of IMTs is poorly understood. Some cases have been linked to translocations involving the ALK gene . Treatment involves surgical removal when possible, although there are reports of treatment with oral steroids and radiation therapy .
MalaCards based summary : Inflammatory Myofibroblastic Tumor, also known as inflammatory fibrosarcoma, is related to epithelioid inflammatory myofibroblastic sarcoma and rare tumor, and has symptoms including fever and pain. An important gene associated with Inflammatory Myofibroblastic Tumor is ALK (ALK Receptor Tyrosine Kinase), and among its related pathways/superpathways are Endometrial cancer and Measles. The drugs Tyrosine and Crizotinib have been mentioned in the context of this disorder. Affiliated tissues include lung, liver and eye, and related phenotypes are Decreased cell migration and Decreased cell migration Disease Ontology : 12 A mesenchymal cell neoplasm that has material basis in myofibroblastic cells admixed with inflammatory cells. |
UMLS symptoms related to Inflammatory Myofibroblastic Tumor:fever, pain GenomeRNAi Phenotypes related to Inflammatory Myofibroblastic Tumor according to GeneCards Suite gene sharing:26
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Drugs for Inflammatory Myofibroblastic Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):
Interventional clinical trials:
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MalaCards organs/tissues related to Inflammatory Myofibroblastic Tumor:40
Lung,
Liver,
Eye,
Bone,
Breast,
Kidney,
Spleen
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Articles related to Inflammatory Myofibroblastic Tumor:(show top 50) (show all 1205)
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GEO
for disease gene expression data for Inflammatory Myofibroblastic Tumor.
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Pathways related to Inflammatory Myofibroblastic Tumor according to GeneCards Suite gene sharing:(show all 18)
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Cellular components related to Inflammatory Myofibroblastic Tumor according to GeneCards Suite gene sharing:
Biological processes related to Inflammatory Myofibroblastic Tumor according to GeneCards Suite gene sharing:
Molecular functions related to Inflammatory Myofibroblastic Tumor according to GeneCards Suite gene sharing:
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