Inflammatory Myofibroblastic Tumor disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: INF058 MIFTS: 51	Inflammatory Myofibroblastic Tumor Categories: Cancer diseases, Rare diseases
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Aliases & Classifications for Inflammatory Myofibroblastic Tumor

MalaCards integrated aliases for Inflammatory Myofibroblastic Tumor:

Name: Inflammatory Myofibroblastic Tumor ¹² ⁵⁴ ⁶⁰ ¹⁵ ⁷⁴

Inflammatory Fibrosarcoma ⁵⁴

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0050905

UMLS via Orphanet ⁷⁵ C0334121

Orphanet ⁶⁰ ORPHA178342

UMLS ⁷⁴ C0334121

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Summaries for Inflammatory Myofibroblastic Tumor

NIH Rare Diseases : ⁵⁴ An inflammatory myofibroblastic tumor (IMT) is an uncommon, usually benign (non-cancerous) tumor made up of cells called myofibroblastic spindle cells. It usually develops in children or young adults, but can affect people of any age. An IMT can occur in almost any part of the body but is most commonly found in the lung, orbit (eye socket), peritoneum (lining of the abdominal cavity and internal organs), and mesentery. Signs and symptoms vary depending on the site of the tumor. Some people with an IMT are asymptomatic, while others may have nonspecific respiratory symptoms, fever, or pain. IMTs may recur, and become locally invasive and/or spread (metastasize) to other parts of the body. However, malignant (cancerous) IMTs are rare. The underlying cause of IMTs is poorly understood. Some cases have been linked to translocations involving the ALK gene. Treatment involves surgical removal when possible, although there are reports of treatment with oral steroids and radiation therapy.

MalaCards based summary : Inflammatory Myofibroblastic Tumor, also known as inflammatory fibrosarcoma, is related to infantile myofibromatosis and anaplastic large cell lymphoma, and has symptoms including fever and pain. An important gene associated with Inflammatory Myofibroblastic Tumor is ALK (ALK Receptor Tyrosine Kinase), and among its related pathways/superpathways are Endometrial cancer and Glioma. The drugs Crizotinib and Doxorubicin have been mentioned in the context of this disorder. Affiliated tissues include lung, liver and bone, and related phenotypes are Reduced mammosphere formation and cardiovascular system

Disease Ontology : ¹² A mesenchymal cell neoplasm that has material basis in myofibroblastic cells admixed with inflammatory cells.

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Related Diseases for Inflammatory Myofibroblastic Tumor

Diseases related to Inflammatory Myofibroblastic Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 226)

#	Related Disease	Score	Top Affiliating Genes
1	infantile myofibromatosis	32.5	ACTC1 DES VIM
2	anaplastic large cell lymphoma	30.8	ALK NPM1 RNF213
3	spindle cell carcinoma	30.6	ACTC1 DES VIM
4	fibrous histiocytoma	30.4	ACTC1 DES VIM
5	fibromatosis	30.2	ACTC1 DES KIT VIM
6	dendritic cell tumor	30.1	ACTC1 CR1 CR2 VIM
7	teratoma	30.1	ACTC1 KIT TP53
8	fibrosarcoma of bone	30.0	CDK4 KIT MDM2
9	histiocytoma	30.0	ALK KIT MDM2 TP53
10	sarcoma	30.0	CDK4 KIT MDM2 TP53 VIM
11	carcinosarcoma	29.9	ACTC1 DES KIT TP53 VIM
12	dedifferentiated liposarcoma	29.9	ACTC1 CDK4 DES MDM2 TP53
13	liposarcoma	29.9	CDK4 DES MDM2 TP53 VIM
14	gastrointestinal stromal tumor	29.8	ACTC1 CCND1 DES KIT TP53 VIM
15	malignant fibroxanthoma	29.8	ACTC1 CDK4 DES MDM2 VIM
16	rhabdomyosarcoma	29.6	ACTC1 ALK CDK4 DES MDM2 TP53
17	adenocarcinoma	29.5	ALK CCND1 CDK4 KIT TP53
18	epithelioid inflammatory myofibroblastic sarcoma	11.6
19	liver inflammatory pseudotumor	11.4
20	desmoid tumor	11.3
21	lymphoma	10.6
22	lymphangiectasis	10.5	ACTC1 VIM
23	mesenchymoma	10.5	DES MDM2
24	infantile digital fibromatosis	10.5	DES VIM
25	glomangiomyoma	10.5	ACTC1 VIM
26	fibroblastic rheumatism	10.5	ACTC1 DES
27	lymphangiomatosis	10.5	DES VIM
28	intravascular papillary endothelial hyperplasia	10.4	ACTC1 VIM
29	cutaneous leiomyosarcoma	10.4	ACTC1 DES
30	primitive neuroectodermal tumor of the cervix uteri	10.4	DES VIM
31	botryoid rhabdomyosarcoma	10.4	ACTC1 DES
32	parameningeal embryonal rhabdomyosarcoma	10.4	ALK TP53
33	angiolipoma	10.4	ACTC1 DES VIM
34	parachordoma	10.4	ACTC1 DES VIM
35	syringocystadenoma papilliferum	10.4	ACTC1 DES VIM
36	ossifying fibromyxoid tumor	10.4	ACTC1 DES VIM
37	epithelioid leiomyosarcoma	10.4	ACTC1 DES VIM
38	mast-cell sarcoma	10.4	KIT VIM
39	benign metastasizing leiomyoma	10.4	ACTC1 DES VIM
40	parapharyngeal meningioma	10.4	CR1 CR2
41	gallbladder sarcoma	10.4	DES KIT
42	cutaneous fibrous histiocytoma	10.4	ACTC1 DES VIM
43	ovarian fibrothecoma	10.4	ACTC1 DES KIT
44	perineurioma	10.4	ALK KIT VIM
45	glomangioma	10.4	ACTC1 DES
46	pulmonary vein stenosis	10.4	ACTC1 DES KIT
47	epulis	10.4	DES VIM
48	acute myeloblastic leukemia with maturation	10.4	KIT NPM1
49	cystic nephroma	10.4	DES KIT VIM
50	anaplastic ependymoma	10.4	MDM2 RNF213 VIM

Graphical network of the top 20 diseases related to Inflammatory Myofibroblastic Tumor:

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Symptoms & Phenotypes for Inflammatory Myofibroblastic Tumor

UMLS symptoms related to Inflammatory Myofibroblastic Tumor:

fever, pain

GenomeRNAi Phenotypes related to Inflammatory Myofibroblastic Tumor according to GeneCards Suite gene sharing:

²⁷

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Reduced mammosphere formation	GR00396-S	9.23	CARS CCND1 CDK4 CLTC DES MDM2

MGI Mouse Phenotypes related to Inflammatory Myofibroblastic Tumor:

⁴⁷

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cardiovascular system	MP:0005385	9.96	ACTC1 CCND1 CDK4 DES KIT MDM2
2	muscle	MP:0005369	9.76	ACTC1 CDK4 DES KIT MDM2 TP53
3	neoplasm	MP:0002006	9.5	ALK CCND1 CDK4 KIT MDM2 NPM1
4	pigmentation	MP:0001186	9.02	ALK CDK4 KIT MDM2 TP53

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Drugs & Therapeutics for Inflammatory Myofibroblastic Tumor

Drugs for Inflammatory Myofibroblastic Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Crizotinib

Approved

Phase 2, Phase 3

877399-52-5

11626560 10366136 10366137 10366138 10366139 10366140 10366141

Doxorubicin

Approved, Investigational

Phase 2, Phase 3

23214-92-8

31703

Daunorubicin

Approved

Phase 2, Phase 3

20830-81-3

30323

Ifosfamide

Approved

Phase 2, Phase 3

3778-73-2

3690

Mechlorethamine

Approved, Investigational

Phase 2, Phase 3

51-75-2

4033

Cyclophosphamide

Approved, Investigational

Phase 2, Phase 3

50-18-0, 6055-19-2

2907

Tyrosine

Approved, Investigational, Nutraceutical

Phase 2, Phase 3

60-18-4

6057

Doxil

Approved June 1999

Phase 2, Phase 3

31703

Protein Kinase Inhibitors

Phase 2, Phase 3,Phase 1

Topoisomerase Inhibitors

Phase 2, Phase 3

Antineoplastic Agents, Alkylating

Phase 2, Phase 3

Anti-Bacterial Agents

Phase 2, Phase 3

Antibiotics, Antitubercular

Phase 2, Phase 3

Alkylating Agents

Phase 2, Phase 3

Isophosphamide mustard

Phase 2, Phase 3

Ensartinib

Investigational

Phase 1, Phase 2

1370651-20-9

Ceritinib

Approved

Phase 1

1032900-25-6

Immunologic Factors

Antibodies

Immunoglobulin G

Immunoglobulins

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Study of Crizotinib in Children and Adolescents With Myofibroblastic Tumors	Recruiting	NCT03874273	Phase 2, Phase 3	Crizotinib
2	Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Hydrochloride Before Surgery in Treating Patients With Newly Diagnosed Non-rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgery	Active, not recruiting	NCT02180867	Phase 2, Phase 3	Doxorubicin;Doxorubicin Hydrochloride;Ifosfamide;Pazopanib;Pazopanib Hydrochloride
3	Phase 1/2 Study of X-396, an Oral ALK Inhibitor, in Patients With ALK-positive Non-Small Cell Lung Cancer	Recruiting	NCT01625234	Phase 1, Phase 2	X-396 (ensartinib)
4	Phase 2 Study Assessing Efficacy and Safety of Crizotinib in Patients Harboring an Alteration on ALK, MET or ROS1	Active, not recruiting	NCT02034981	Phase 2	Crizotinib
5	CREATE: Cross-tumoral Phase 2 With Crizotinib	Active, not recruiting	NCT01524926	Phase 2	Crizotinib (PF-02341066)
6	Phase I Study of LDK378 in Pediatric, Malignancies With a Genetic Alteration in Anaplastic Lymphoma Kinase (ALK)	Completed	NCT01742286	Phase 1	LDK378
7	A Prospective Cohort Study of IgG4RD in China	Recruiting	NCT01670695
8	Low-dose Protocol for Computed Tomography-guided Lung Biopsy	Active, not recruiting	NCT02971176	Not Applicable
9	Treatment With Crizotinib Single Patient Expanded Access IND 134375	No longer available	NCT03085186		Crizotinib

Search NIH Clinical Center for Inflammatory Myofibroblastic Tumor

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Genetic Tests for Inflammatory Myofibroblastic Tumor

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Anatomical Context for Inflammatory Myofibroblastic Tumor

MalaCards organs/tissues related to Inflammatory Myofibroblastic Tumor:

⁴²

Lung, Liver, Bone, Eye, Kidney, Trachea, Heart

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Publications for Inflammatory Myofibroblastic Tumor

Articles related to Inflammatory Myofibroblastic Tumor:

(show top 50) (show all 736)

#	Title	Authors	Year
1	Differentiation between inflammatory myofibroblastic tumor and cholangiocarcinoma manifesting as target appearance on gadoxetic acid-enhanced MRI. ( 30515535 )	Chang AI...Lee SJ	2019
2	Hepatobiliary and Pancreatic: Inflammatory myofibroblastic tumor of the liver mimicking intrahepatic cholangiocarcinoma with hilar lymph node metastasis. ( 30215848 )	Lu J...Cheng NS	2019
3	Morphologic Overlap Between Inflammatory Myofibroblastic Tumor and IgG4-related Disease: Lessons From Next-generation Sequencing. ( 30451733 )	Taylor MS...Deshpande V	2019
4	Effectiveness of Crizotinib for Inflammatory Myofibroblastic Tumor with ALK mutation. ( 30449794 )	Ogata M...Yasui H	2019
5	Metastatic inflammatory myofibroblastic tumor of the bladder. ( 30505686 )	Libby EK...Murray KS	2019
6	Inflammatory myofibroblastic tumor of urinary bladder with severe hematuria: A Case report and literature review. ( 30608442 )	Song D...Fan Y	2019
7	A Surgical Case of Inflammatory Myofibroblastic Tumor of the Liver: Potentially Characteristic Gross Features. ( 30799968 )	Watanabe J...Iwagaki H	2019
8	A Rare Presentation of Inflammatory Myofibroblastic Tumor in the Nasolabial Fold. ( 30809407 )	Alshammari HK...Kussaibi H	2019
9	Inflammatory Myofibroblastic Tumor of the Retroperitoneum Including Chronic Granulomatous Inflammation Suggesting Tuberculosis: A Case Report. ( 30889946 )	Kim Y...Park KJ	2019
10	Inflammatory myofibroblastic tumor. 18F-FDG PET/CT findings. ( 30366728 )	D?az Silv?n A...Mart?nez Gimeno E	2019
11	Gastric inverted hyperplastic polyp with inflammatory myofibroblastic tumor-like stroma, mimicking GI stromal tumor. ( 30339952 )	Koh J...Chang MS	2019
12	Inflammatory Myofibroblastic Tumor in Female Genital Tract. ( 29965784 )	Shukla PS...Mittal K	2019
13	Inflammatory Myofibroblastic Tumor of the Stomach Presenting as an Exophytic Mass - A Diagnostic Dilemma. ( 28272683 )	Jadhav M...Kittur S	2019
14	ALK Negative Inflammatory Myofibroblastic Tumor Synchronous with Classical Hodgkin Lymphoma. ( 31043949 )	Sandoval L...Zattar Piazera F	2019
15	Letter in Reply: Appendiceal Inflammatory Myofibroblastic Tumor and HIV Infection, An Association Not To Be Missed. ( 30918618 )	Al-Rikabi AC	2019
16	Appendiceal Inflammatory Myofibroblastic Tumor and HIV Infection, An Association Not To Be Missed. ( 30918617 )	Al-Mendalawi MD	2019
17	Successful role of adjuvant radiotherapy in a rare case of tracheal inflammatory myofibroblastic tumor: a case report. ( 30900517 )	Lisi R...Tombolini V	2019
18	Durable response to the ALK inhibitor alectinib in inflammatory myofibroblastic tumor of the head and neck with a novel SQSTM1-ALK fusion: a case report. ( 30790150 )	Honda K...Muro K	2019
19	Spectral Computed Tomography Imaging in the Differential Diagnosis of Lung Cancer and Inflammatory Myofibroblastic Tumor. ( 30762653 )	Yu Y...Hu C	2019
20	Uterine Inflammatory Myofibroblastic Tumor Showing an Atypical ALK Signal Pattern by FISH and DES-ALK Fusion by RNA Sequencing: A Case Report. ( 30741845 )	Zarei S...Policarpio-Nicolas MLC	2019
21	Intracranial inflammatory myofibroblastic tumor with negative expression of anaplastic lymphoma kinase: a case report and review of the literature. ( 30735872 )	Wang X...Zhang H	2019
22	ALK inhibition in two emblematic cases of pediatric inflammatory myofibroblastic tumor: Efficacy and side effects. ( 30697903 )	Brivio E...Zwaan CM	2019
23	ALK-negative urachal inflammatory myofibroblastic tumor in an elderly female: A case report: Erratum. ( 30653181 )		2019
24	Case report: Crizotinib is effective in a patient with ROS1-rearranged pulmonary inflammatory myofibroblastic tumor. ( 30642440 )	Mai S...Cai R	2019
25	Core Biopsy Diagnosis of ALK Positive Inflammatory Myofibroblastic Tumor of Lung: An Interesting Case. ( 30632123 )	Sachdev R...Sharma N	2019
26	An Unusual Case of Inflammatory Myofibroblastic Tumor of the Appendix Masquerading as Acute Appendicitis. ( 29896334 )	Bashir MR...Al-Rikabi AC	2018
27	An interesting case of inflammatory myofibroblastic tumor presenting as cholangiocarcinoma. ( 29705678 )	Karimi M...Shabestanipour G	2018
28	Inflammatory Myofibroblastic Tumor of the Mid Common Bile Duct Masquerading as Cholangiocarcinoma. ( 29453762 )	Verma R...Saha K	2018
29	A dedifferentiated liposarcoma with inflammatory myofibroblastic tumor-like features. ( 29446522 )	Kai K...Aishima S	2018
30	Pediatric inflammatory myofibroblastic tumor of the trachea: Imaging spectrum and review of literature. ( 30381563 )	Chauhan RS...Mathew J	2018
31	Laser Treatment of a Tracheal Inflammatory Myofibroblastic Tumor. ( 30426959 )	Vijayasekaran D...Ramesh S	2018
32	Ureteral inflammatory myofibroblastic tumor: A case report and literature review. ( 30431591 )	Li F...Hou Y	2018
33	Cardiac inflammatory myofibroblastic tumor in interventricular septum: A rare case report. ( 30508903 )	Deng MD...Tang H	2018
34	Minimally invasive surgery for inflammatory myofibroblastic tumor of the urinary bladder: Three case reports. ( 30544437 )	Xu H...Wei Q	2018
35	Primary gastric inflammatory myofibroblastic tumor: A case report. ( 30557996 )	Cheng B...Zhou L	2018
36	ALK-negative urachal inflammatory myofibroblastic tumor in an elderly female: A case report. ( 30572472 )	Wang K...Wang G	2018
37	Inflammatory Myofibroblastic Tumor of the Liver: Challenges in the Preoperative Diagnosis and Treatment. ( 29235003 )	Liu F...Li FY	2018
38	Inflammatory Myofibroblastic Tumor of the Tongue. Report of a Pediatric Case and Review of the Literature. ( 29336647 )	Caporalini C...Buccoliero AM	2018
39	Inflammatory myofibroblastic tumor of the esophagus presenting with hematemesis and melaena: a case report and review of literature. ( 29375843 )	Jayarajah U...Samarasekera DN	2018
40	Inflammatory Myofibroblastic Tumor Driven by Novel NUMA1-ALK Fusion Responds to ALK Inhibition. ( 29439172 )	Rao N...Liebner DA	2018
41	Inflammatory myofibroblastic tumor of the lung. ( 29490419 )	Khatri A...Meena N	2018
42	Double amplifications of CDK4 and MDM2 in a gastric inflammatory myofibroblastic tumor mimicking cancer with local invasion of the spleen and diaphragm. ( 30252584 )	He J...Li S	2018
43	Inflammatory Myofibroblastic Tumor of Urinary Bladder. ( 30203811 )	Wang W...Li QY	2018
44	Inflammatory myofibroblastic tumor of the pleura with adjacent chest wall invasion and metastasis to the kidney: a case report. ( 30195334 )	Na YS...Park SG	2018
45	Uncommon Imaging Findings of Inflammatory Myofibroblastic Tumor: Report of a Rare Case With Both Omentum and Mesentery Involvement in the Abdominal Cavity. ( 30153139 )	Fu H...Chen H	2018
46	Inflammatory myofibroblastic tumor of the epiglottis excised with a carbon dioxide laser: Case report and literature review. ( 30138523 )	Raggio B...Chheda N	2018
47	Imaging findings of inflammatory myofibroblastic tumor in breast: A case report. ( 30095645 )	Mao X...Zhang L	2018
48	A Rare Case of Inflammatory Myofibroblastic Tumor of Meninges. ( 30090151 )	Lata KA...Pawar SS	2018
49	Gastric inflammatory myofibroblastic tumor treated with combined laparoscopic and endoscopic gastric wedge resection: a case report. ( 30089486 )	Hayashi M...Kitagawa Y	2018
50	Inflammatory myofibroblastic tumor of the larynx. ( 30036428 )	Wang YH...Chang WC	2018

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Genes for Inflammatory Myofibroblastic Tumor

Genes related to Inflammatory Myofibroblastic Tumor (6 elite genes):

(show all 24)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	ALK	ALK Receptor Tyrosine Kinase	Protein Coding	377.62	Gene fusion ⁶⁰ DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
2	RANBP2	RAN Binding Protein 2	Protein Coding	374.43	Gene fusion ⁶⁰ DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
3	TPM3	Tropomyosin 3	Protein Coding	373.59	Gene fusion ⁶⁰ DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
4	CARS	Cysteinyl-TRNA Synthetase	Protein Coding	365.03	Gene fusion ⁶⁰ DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
5	CLTC	Clathrin Heavy Chain	Protein Coding	356.64	Gene fusion ⁶⁰ DISEASES inferred ¹⁵
6	TPM4	Tropomyosin 4	Protein Coding	356.08	Gene fusion ⁶⁰ DISEASES inferred ¹⁵
7	RNF213	Ring Finger Protein 213	Protein Coding	26.76	GeneCards inferred via : Publications Summaries (show sections)
8	SEC31A	SEC31 Homolog A, COPII Coat Complex Component	Protein Coding	24.05	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
9	KIT	KIT Proto-Oncogene, Receptor Tyrosine Kinase	Protein Coding	22.24	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
10	CR1	Complement C3b/C4b Receptor 1 (Knops Blood Group)	Protein Coding	22.07	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
11	CR2	Complement C3d Receptor 2	Protein Coding	22.01	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
12	NPM1	Nucleophosmin 1	Protein Coding	21.49	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
13	ACTC1	Actin Alpha Cardiac Muscle 1	Protein Coding	21.13	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
14	MDM2	MDM2 Proto-Oncogene	Protein Coding	21.09	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
15	TP53	Tumor Protein P53	Protein Coding	20.33	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
16	CCND1	Cyclin D1	Protein Coding	20.29	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
17	HNRNPA1	Heterogeneous Nuclear Ribonucleoprotein A1	Protein Coding	19.75	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
18	CDK4	Cyclin Dependent Kinase 4	Protein Coding	19.71	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
19	VIM	Vimentin	Protein Coding	17.69	GeneCards inferred via : Publications (show sections)
20	DES	Desmin	Protein Coding	17.61	GeneCards inferred via : Publications (show sections)
21	PPFIBP1	PPFIA Binding Protein 1	Protein Coding	12.44	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
22	EML4	EMAP Like 4	Protein Coding	10.91	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
23	S100B	S100 Calcium Binding Protein B	Protein Coding	7.52	GeneCards inferred via : Publications (show sections)
24	ACVRL1	Activin A Receptor Like Type 1	Protein Coding	7.41	GeneCards inferred via : Publications (show sections)

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Variations for Inflammatory Myofibroblastic Tumor

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Expression for Inflammatory Myofibroblastic Tumor

Search GEO for disease gene expression data for Inflammatory Myofibroblastic Tumor.

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Pathways for Inflammatory Myofibroblastic Tumor

Pathways related to Inflammatory Myofibroblastic Tumor according to GeneCards Suite gene sharing:

(show all 32)

#	Super pathways	Score	Top Affiliating Genes
1	Endometrial cancer ³⁸ Show member pathways Acute myeloid leukemia ³⁸ Binding of TCF/LEF-CTNNB1 to target gene promoters ⁶⁷ Chronic myeloid leukemia ³⁸ Colorectal cancer ³⁸ Pancreatic cancer ³⁸ Prostate cancer ³⁸ Signal transduction PTEN pathway ²³ Thyroid cancer ³⁸	12.72	CCND1 CDK4 KIT MDM2 TP53 TPM3
2	Glioma ³⁸ Show member pathways Endocrine resistance ³⁸ Melanoma ³⁸ Non-small cell lung cancer ³⁸ Signaling Pathways in Glioblastoma ¹	12.6	ALK CCND1 CDK4 MDM2 TP53
3	Pathways in cancer ³⁸	12.53	ALK CCND1 CDK4 KIT MDM2 TP53
4	Cytoskeletal Signaling ⁴	12.4	ACTC1 CLTC DES SEC31A VIM
5	WNT Signaling ⁶⁵	12.35	CCND1 CDK4 TP53 VIM
6	DNA Damage Response ¹ Show member pathways miRNA Regulation of DNA Damage Response ¹ p53 signaling pathway ³⁸	12.29	CCND1 CDK4 MDM2 TP53
7	Cell cycle ³⁸ ¹	12.28	CCND1 CDK4 MDM2 TP53
8	Viral carcinogenesis ³⁸	12.21	CCND1 CDK4 MDM2 TP53
9	p53 Signaling ⁶⁵ Show member pathways p53 Pathway ⁶⁸	12.14	CCND1 CDK4 MDM2 TP53
10	MAPK Signaling: Mitogen Stimulation Pathway ⁶⁶ Show member pathways Akt Signaling Pathway ⁶⁶	12.13	CCND1 CDK4 MDM2 TP53
11	Dilated cardiomyopathy (DCM) ³⁸ Show member pathways Hypertrophic cardiomyopathy (HCM) ³⁸	12.12	ACTC1 DES TPM3 TPM4
12	DNA Damage ⁴	12.1	CCND1 CDK4 MDM2 NPM1 TP53 VIM
13	Cellular senescence (KEGG) ³⁸	12.06	CCND1 CDK4 MDM2 TP53
14	AKT Signaling Pathway ⁶⁸	12.05	CCND1 CDK4 MDM2 TP53
15	Integrated Breast Cancer Pathway ¹	12.01	CCND1 CDK4 MDM2 TP53
16	Hematopoietic cell lineage ³⁸	11.82	CR1 CR2 KIT
17	Spinal Cord Injury ¹	11.81	CCND1 CDK4 TP53 VIM
18	Small cell lung cancer ³⁸	11.79	CCND1 CDK4 TP53
19	Glioblastoma Multiforme ⁶⁵	11.75	CCND1 CDK4 MDM2 TP53
20	Validated targets of C-MYC transcriptional activation ¹	11.72	CDK4 NPM1 TP53
21	Cardiac muscle contraction ³⁸	11.7	ACTC1 TPM3 TPM4
22	Retinoblastoma (RB) in Cancer ¹	11.61	CCND1 CDK4 MDM2 TP53
23	Copper homeostasis ¹	11.5	CCND1 MDM2 TP53
24	Proteolysis Putative SUMO-1 pathway ²³ Show member pathways DNA damage Role of SUMO in p53 regulation ²³	11.49	MDM2 RANBP2 TP53
25	Bladder cancer ¹ ³⁸	11.49	CCND1 CDK4 MDM2 TP53
26	Integrated Cancer Pathway ¹	11.39	CDK4 MDM2 TP53
27	Aurora B signaling ¹ Show member pathways Aurora C signaling ¹ Signaling by Aurora kinases ¹	11.37	DES NPM1 VIM
28	GADD45 Pathway ⁶⁵	11.16	CCND1 CDK4 TP53
29	Oncogene Induced Senescence ⁶⁷	11.14	CDK4 MDM2 TP53
30	DNA damage_ATM/ATR regulation of G1/S checkpoint ²³	10.9	CCND1 CDK4 MDM2 TP53
31	Striated Muscle Contraction ¹ ⁶⁷	10.88	ACTC1 DES TPM3 TPM4 VIM
32	Sumoylation by RanBP2 regulates transcriptional repression ¹	10.68	MDM2 RANBP2

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GO Terms for Inflammatory Myofibroblastic Tumor

Cellular components related to Inflammatory Myofibroblastic Tumor according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protein-containing complex	GO:0032991	9.85	ALK CDK4 CLTC MDM2 NPM1 TP53
2	extracellular exosome	GO:0070062	9.85	ACTC1 ALK CLTC CR1 CR2 DES
3	cytosol	GO:0005829	9.83	ACTC1 CARS CCND1 CDK4 CLTC DES
4	focal adhesion	GO:0005925	9.8	ACTC1 CLTC NPM1 TPM4 VIM
5	actin filament	GO:0005884	9.61	ACTC1 TPM3 TPM4
6	cytoplasm	GO:0005737	9.55	ACTC1 CARS CCND1 CDK4 CLTC DES
7	muscle thin filament tropomyosin	GO:0005862	9.26	TPM3 TPM4
8	membrane	GO:0016020	10.22	ACTC1 ALK CCND1 CDK4 CLTC CR1
9	cytoskeleton	GO:0005856	10	ACTC1 CLTC DES NPM1 TPM3 TPM4

Biological processes related to Inflammatory Myofibroblastic Tumor according to GeneCards Suite gene sharing:

(show all 13)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of cell proliferation	GO:0008284	9.91	CCND1 CDK4 KIT MDM2 NPM1
2	cytokine-mediated signaling pathway	GO:0019221	9.83	CCND1 KIT TP53 VIM
3	positive regulation of gene expression	GO:0010628	9.8	ACTC1 KIT MDM2 TP53 VIM
4	positive regulation of translation	GO:0045727	9.63	CDK4 NPM1 VIM
5	negative regulation of apoptotic process	GO:0043066	9.62	ACTC1 MDM2 NPM1 TP53
6	viral process	GO:0016032	9.56	CR1 CR2 HNRNPA1 MDM2 NPM1 RANBP2
7	positive regulation of cell cycle	GO:0045787	9.54	CCND1 CDK4 MDM2
8	complement receptor mediated signaling pathway	GO:0002430	9.49	CR1 CR2
9	response to magnesium ion	GO:0032026	9.48	CCND1 MDM2
10	mitotic G1 DNA damage checkpoint	GO:0031571	9.43	CCND1 TP53
11	negative regulation of cell cycle arrest	GO:0071157	9.33	CCND1 CDK4 MDM2
12	cellular response to actinomycin D	GO:0072717	9.26	MDM2 TP53
13	muscle filament sliding	GO:0030049	9.02	ACTC1 DES TPM3 TPM4 VIM

Molecular functions related to Inflammatory Myofibroblastic Tumor according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	identical protein binding	GO:0042802	9.43	ALK DES MDM2 TP53 TPM4 VIM
2	disordered domain specific binding	GO:0097718	8.8	CLTC MDM2 TP53
3	protein binding	GO:0005515	10.09	ALK CARS CCND1 CDK4 CLTC CR2

Sources

Sources for Inflammatory Myofibroblastic Tumor

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FDA Approved Drugs

²⁰ FMA

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ Genetics Home Reference

²⁷ GenomeRNAi

²⁸ GEO DataSets

²⁹ GO

³⁰ GTR

³¹ HGMD

³² HMDB

³³ HPO

³⁴ ICD10

³⁵ ICD10 via Orphanet

³⁶ ICD9CM

³⁷ IUPHAR

³⁸ KEGG

³⁹ LifeMap

⁴⁰ LncRNADisease

⁴¹ LOVD

⁴² MalaCards

⁴³ MedGen

⁴⁴ MedlinePlus

⁴⁵ MeSH

⁴⁶ MESH via Orphanet

⁴⁷ MGI

⁴⁸ miR2Disease

⁴⁹ NCBI Bookshelf

⁵⁰ NCI

⁵¹ NCIt

⁵² NDF-RT

⁵³ NIH Clinical Center

⁵⁴ NIH Rare Diseases

⁵⁵ NINDS

⁵⁶ Novoseek

⁵⁷ Novus Biologicals

⁵⁸ OMIM

⁵⁹ OMIM via Orphanet

⁶⁰ Orphanet

⁶¹ PathCards

⁶² PharmGKB

⁶³ PubMed

⁶⁴ PubMed Health

⁶⁵ QIAGEN

⁶⁶ R&D Systems

⁶⁷ Reactome

⁶⁸ Sino Biological

⁶⁹ SNOMED-CT

⁷⁰ SNOMED-CT via HPO

⁷¹ SNOMED-CT via Orphanet

⁷² TGDB

⁷³ Tocris

⁷⁴ UMLS

⁷⁵ UMLS via Orphanet

⁷⁶ UniProtKB/Swiss-Prot

⁷⁷ Wikipedia