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FLU
MCID: INF038
MIFTS: 76

Influenza (FLU)

Categories: Gastrointestinal diseases, Genetic diseases, Infectious diseases, Oral diseases, Respiratory diseases, Smell/Taste diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
Sources

Aliases & Classifications for Influenza

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MalaCards integrated aliases for Influenza:

Name: Influenza 12 76 29 55 6 3 3 15 73
Flu 12 43 3 63
Influenza with Non-Respiratory Manifestation 12
Influenza with Other Manifestations 12
Influenza, Susceptibility to 40
Influenza, Human 44

Classifications:

MalaCards categories:
Global: Infectious diseases Genetic diseases
Anatomical: Respiratory diseases Gastrointestinal diseases Smell/Taste diseases Oral diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:8469
ICD9CM 35 487
MeSH 44 D007251
NCIt 50 C53482
SNOMED-CT 68 6142004
UMLS 73 C0021400
Sources

Summaries for Influenza

About this section
MedlinePlus : 43 Flu is a respiratory infection caused by a number of viruses. The viruses pass through the air and enter your body through your nose or mouth. Between 5% and 20% of people in the U.S. get the flu each year. The flu can be serious or even deadly for elderly people, newborn babies, and people with certain chronic illnesses. Symptoms of the flu come on suddenly and are worse than those of the common cold. They may include Body or muscle aches Chills Cough Fever Headache Sore throat Is it a cold or the flu? Colds rarely cause a fever or headaches. Flu almost never causes an upset stomach. And "stomach flu" isn't really flu at all, but gastroenteritis. Most people with the flu recover on their own without medical care. People with mild cases of the flu should stay home and avoid contact with others, except to get medical care. If you get the flu, your health care provider may prescribe medicine to help your body fight the infection and lessen symptoms. The main way to keep from getting the flu is to get a yearly flu vaccine. Good hygiene, including hand washing, can also help. NIH: National Institute of Allergy and Infectious Diseases

MalaCards based summary : Influenza, also known as flu, is related to avian influenza and viral infectious disease, and has symptoms including fever, pruritus and snoring. An important gene associated with Influenza is IFITM3 (Interferon Induced Transmembrane Protein 3), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Tequin and Hops have been mentioned in the context of this disorder. Affiliated tissues include testes, t cells and lung.

Disease Ontology : 12 A viral infectious disease that results in infection, located in respiratory tract, has material basis in Influenzavirus A, has material basis in Influenzavirus B, or has material basis in Influenzavirus C, which are transmitted by droplet spread of oronasal secretions during coughing, sneezing, or talking from an infected person. It is a highly contagious disease that affects birds and mammals and has symptom chills, has symptom fever, has symptom sore throat, has symptom runny nose, has symptom muscle pains, has symptom severe headache, has symptom cough, and has symptom weakness.

CDC : 3 Flu Report

PubMed Health : 63 About flu: People often talk about having the flu (influenza) when they come down with a cold. Yet the course of these two illnesses is very different and they also typically have different signs and symptoms.Colds are much more common than the flu. They also start quite slowly, while the viruses that cause the flu strike quickly and cause more severe symptoms – even in people who are otherwise quite healthy. The flu makes you feel very ill quite suddenly. Colds don't usually cause any serious harm, and are often over within a week, with or without treatment. It is a good idea to see a doctor if you have the flu, and it may take some time before you fully recover.But colds and the flu do have one thing in common: The treatment for both focuses on relieving the symptoms. The only medicines that target the flu viruses directly can at most reduce the time you are ill. But a number of things can be done to avoid infection in the first place.

Wikipedia : 76 Influenza, commonly known as "the flu", is an infectious disease caused by an influenza virus. Symptoms... more...

Sources

Related Diseases for Influenza

About this section

Diseases in the Influenza family:

Influenza, Severe

Diseases related to Influenza via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 649)
# Related Disease Score Top Affiliating Genes
1 avian influenza 34.5 DDX58 FURIN IRF7
2 viral infectious disease 31.8 DDX58 IFNA1 IFNG IRF7 ISG15 MX1
3 severe acute respiratory syndrome 30.6 IFNA1 IFNG MX1 TMPRSS2
4 stomatitis 30.4 DDX58 IFITM3 RSAD2
5 measles 30.4 DDX58 IFNA1 IFNG
6 noonan syndrome 2 30.4 DDX58 XPO1
7 dengue virus 30.1 DDX58 IFITM3 RSAD2
8 mouth disease 29.9 IFNA1 IFNG MX1
9 hepatitis c 29.9 DDX58 IFNA1 IFNG IRF7
10 hepatitis c virus 29.8 DDX58 IFNG IRF7 RSAD2
11 rift valley fever 29.7 IFITM3 MX1
12 west nile virus 29.7 DDX58 IFITM3 IFNA1 RSAD2
13 relapsing-remitting multiple sclerosis 29.4 IFNA1 IFNG MX1
14 swine influenza 12.7
15 haemophilus influenzae 12.6
16 influenza, severe 12.1
17 viral pneumonia 11.5
18 haemophilus meningitis 11.5
19 acute necrotizing encephalopathy 11.4
20 encephalopathy, acute, infection-induced 4 11.4
21 epiglottitis 11.3
22 aspergillosis 11.3
23 common cold 11.3
24 lung disease 11.3
25 croup 11.3
26 human immunodeficiency virus type 1 11.3
27 acquired immunodeficiency syndrome 11.3
28 acute diarrhea 11.2
29 gastroenteritis 11.2
30 specific antibody deficiency 11.1
31 bacterial pneumonia 11.1
32 complement component 3 deficiency, autosomal recessive 10.9
33 immunodeficiency 39 10.9
34 pontiac fever 10.9
35 ross river fever 10.9
36 haverhill fever 10.9
37 white matter hypoplasia-corpus callosum agenesis-intellectual disability syndrome 10.9
38 mda5 deficiency 10.9
39 bronchitis 10.8
40 pneumonia 10.7
41 bronchopneumonia 10.6
42 meningitis 10.5
43 tetanus 10.5
44 pertussis 10.5
45 newcastle disease 10.5
46 diphtheria 10.5
47 streptococcus pneumonia 10.5
48 ornithosis 10.4
49 mycoplasma pneumoniae pneumonia 10.4
50 hepatitis 10.4

Graphical network of the top 20 diseases related to Influenza:



Diseases related to Influenza
Sources

Symptoms & Phenotypes for Influenza

About this section

UMLS symptoms related to Influenza:


fever, pruritus, snoring, coughing, symptoms, influenza-like symptoms, fever, catarrhal, acute
Sources

Drugs & Therapeutics for Influenza

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PubMedHealth treatment related to Influenza: 63

Many people turn to home remedies like chicken broth and herbal teas to relieve flu symptoms. And getting plenty to drink is also considered to be important. But there is no scientific proof that any of these things helps speed up recovery. So you don't necessarily need to rely on any of the remedies or to drink more fluids than you feel like.A number of freely available products like vitamin supplements or inhalation devices are marketed for the treatment of colds, flus and coughs. But there is no compelling evidence that they are effective against the flu. Painkillers such as acetaminophen (paracetamol), acetylsalicylic acid (ASA, the drug in medicines like Aspirin) and ibuprofen can relieve pain and lower fever. But children and teenagers should not take ASA because in rare cases this drug can cause a serious brain condition in these age groups.In addition to over-the-counter products, prescription-only medication is also available. The most common of these in Germany is oseltamivir (trade name: Tamiflu). Oseltamivir is prescription-only and needs to be taken within two days after the flu starts. It does not have any effect on the course of the flu infection if you have already had symptoms for longer. Some research suggests that oseltamivir could reduce the period of illness by up to one day. But it often causes nausea and vomiting. It is not clear that it helps to prevent complications. Some people think that antibiotics will help in the treatment of flu. But antibiotics are only effective against bacteria, not against viruses. So antibiotics only help if you have a bacterial infection of the airways as well as a viral infection. Unless there are signs of bacterial infection, there is no point in taking antibiotics.

FDA approved drugs:

# Drug Name Active Ingredient(s) 18 Company Approval Date
1
Tequin 18 Bristol-Myers Squibb December, 1999

Drugs for Influenza (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 972)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Hops Approved Phase 4,Phase 3,Phase 1,Phase 2
2
Oseltamivir Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 204255-11-8, 196618-13-0 65028
3
Azelastine Approved Phase 4,Phase 1 58581-89-8 2267
4
Histamine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 51-45-6, 75614-87-8 774
5
Fluticasone Approved, Experimental Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 90566-53-3 62924
6
Triamcinolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1 124-94-7 31307
7
Lidocaine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 137-58-6 3676
8
Amoxicillin Approved, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 26787-78-0 33613
9 Strawberry Approved Phase 4,Phase 3
10
4-Aminopyridine Approved Phase 4,Phase 3,Phase 2,Phase 1 504-24-5 1727
11
Glucosamine Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 3416-24-8 439213
12
Cisatracurium Approved Phase 4 96946-41-7
13
Atracurium Approved, Experimental, Investigational Phase 4 64228-79-1 47319
14
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
15
Formaldehyde Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 50-00-0 712
16
Phenylephrine Approved Phase 4,Phase 3,Phase 1 59-42-7 6041
17
Acetaminophen Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 103-90-2 1983
18
Ephedrine Approved Phase 4,Phase 3,Phase 1 299-42-3 9294
19
Pseudoephedrine Approved Phase 4,Phase 3,Phase 1 90-82-4 7028
20
Oxymetazoline Approved, Investigational Phase 4,Phase 3,Phase 1 1491-59-4 4636
21
Adalimumab Approved Phase 4,Phase 3,Phase 2 331731-18-1 16219006
22
leucovorin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 58-05-9 6006 143
23
Methotrexate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 59-05-2, 1959-05-2 126941
24
Guaifenesin Approved, Investigational, Vet_approved Phase 4,Phase 3,Not Applicable 93-14-1 3516
25 tannic acid Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
26
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 94-09-7, 1994-09-7 2337
27
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 51-61-6, 62-31-7 681
28
Amantadine Approved Phase 4,Phase 2,Phase 1 768-94-5 2130
29
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 22916-47-8 4189
30
Heparin Approved, Investigational Phase 4,Phase 3 9005-49-6 772 46507594
31
Calcium Carbonate Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 471-34-1
32
Iron Approved Phase 4,Phase 3,Phase 2,Not Applicable 7439-89-6 23925
33
Acetylcholine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 51-84-3 187
34
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 302-25-0
35
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-24-8 5755
36
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 83-43-2 6741
37
Methylprednisolone hemisuccinate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 2921-57-5
38
Fludarabine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 75607-67-9, 21679-14-1 30751
39
Tacrolimus Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 104987-11-3 445643 439492
40
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 6055-19-2, 50-18-0 2907
41
Mycophenolic acid Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 24280-93-1 446541
42
Busulfan Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 55-98-1 2478
43
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable 1177-87-3
44
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable 50-02-2 5743
45
Metformin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 657-24-9 14219 4091
46
Capecitabine Approved, Investigational Phase 4,Phase 2,Phase 1 154361-50-9 60953
47
Caffeine Approved Phase 4,Phase 3,Not Applicable 58-08-2 2519
48
Infliximab Approved Phase 4,Phase 3,Phase 2,Not Applicable 170277-31-3
49
Morphine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 57-27-2 5288826
50
Fluconazole Approved, Investigational Phase 4,Phase 3,Phase 2 86386-73-4 3365

Interventional clinical trials:

(show top 50) (show all 4733)
# Name Status NCT ID Phase Drugs
1 The Effect and Safety of the Seasonal Trivalent Influenza Vaccine in Chronic Kidney Disease Patients Not on Dialysis Unknown status NCT02105519 Phase 4
2 Safety and Efficacy of Intradermal Trivalent Influenza Vaccination in Institutionalized Older Adults Unknown status NCT01967368 Phase 4 Intanza;Vaxigrip
3 Optimizing Influenza Vaccination in Surgical Oncology Patients Unknown status NCT01698177 Phase 4
4 A Study of Arbidol (Umifenovir) for Treatment and Prophylaxis of Influenza and Common Cold Unknown status NCT01651663 Phase 4 Arbidol (Umifenovir);Arbidol (Umifenovir)
5 Study of Immune Responses After Vaccination Against Seasonal Influenza Virus and Against Influenza H1N1-v Pandemic Virus in a Medical Staff. Unknown status NCT01063608 Phase 4
6 Banlangen Granules Anti-seasonal Influenza Study Unknown status NCT02232945 Phase 4 placebo of oseltamivir phosphate;oseltamivir phosphate;Banlangen (Radix Isatidis) granules;placebo of Banlangen(Radix Isatidis) granules
7 Comparison of the Cellular and the Humoral Immunogenicity, Safety of Different Trivalent Influenza Vaccines Unknown status NCT01119157 Phase 4
8 Influenza Vaccination in Patients With Scleroderma Unknown status NCT01002508 Phase 4
9 Immunogenicity and Safety of a Trivalent Inactivated Influenza Vaccine,Formulation 2011-2012, in Dialysis Patients Unknown status NCT01512056 Phase 4 AdimFlu-S
10 Immunogenicity of Influenza Vaccines in HIV-infected Persons in Thailand Unknown status NCT01538940 Phase 4
11 Cell Immunity Response to Vaccination Against Influenza in Patients With Rheumatoid Arthritis Unknown status NCT01002716 Phase 4
12 A Randomised Controlled Trial on the Effect of Post-exposure Oseltamivir Prophylaxis on Influenza Transmission in Nursing Homes Unknown status NCT01053377 Phase 4 Tamiflu (verum);Tamiflu placebo
13 Chinese Medicinal Herbs Treatment on Novel Influenza A (H1N1)Pneumonia: Multi-centre, Prospective, Randomized Controlled Study Unknown status NCT00936013 Phase 4 oseltamivir;oseltamivir and chinese medicinal herbs
14 The Impact of Vitamin on the Clinical Course in Cases Infected by Novel H1N1 Influenza Virus A Unknown status NCT01127282 Phase 4 Vitamin (vitamin A 15 mg,C 500 mg, E 400IU);Placebo (digestive tablet)
15 Seasonal Influenza Vaccine, Quadrivalent Versus Trivalent in Patients With Advanced Chronic Obstructive Pulmonary Disease Unknown status NCT02563184 Phase 4
16 Effect of Tocilizumab to the Cellular Immune Response to Influenza Vaccine Unknown status NCT01980836 Phase 4
17 Immune Response Analysis to Influenza Vaccine in Elderly Aged Over 65 Years Unknown status NCT01289535 Phase 4
18 Safety and Immune Response to Adjuvanted A(H1N1)v Influenza Vaccine in HIV-1 Infected and Immunosuppressed Adult Patients Unknown status NCT01017172 Phase 4
19 Safety and Efficacy of Anti-Pandemic H1N1 Vaccination in Rheumatic Diseases Unknown status NCT01151644 Phase 4
20 AZELASTINE/FLUTICASONE (AZE/FLU) Nasal Spray on Symptom Control, Nasal Mediators and Nasal Hyperresponsiveness in Allergic Rhinitis (AR) Unknown status NCT02238353 Phase 4 azelastine + fluticasone;Placebo
21 Comparing Treatment Efficacy With HD/MD Flu Plus Sal in Chronic Obstructive Pulmonary Disease (COPD) Patients Unknown status NCT01131806 Phase 4 fluticasone/ salmeterol 125/25 mcg/puff;fluticasone/ salmeterol 250/25 mcg/puff
22 Body Composition Measurements in Chronic Heart Failure Unknown status NCT02686866 Phase 4
23 Corticosteroid Injection Verses High Energy Extracorporeal Shock Wave Therapy for Lateral Epicondylitis Unknown status NCT02613455 Phase 4 Kenalog (triamcinolone);lidocaine 1% (lidocaine HCl 20mg)
24 Middle Meatal Bacteriology During Acute Respiratory Infection in Children Unknown status NCT00545961 Phase 4 placebo;amoxicillin clavulanate acid
25 Frailty and Cognitive Function Assessment of TAVI Patients Unknown status NCT02650388 Phase 4
26 Safety, Long Term Immunogenicity and Lot Consistency Study of Liquid Pentavalent Combination Vaccine Unknown status NCT00877357 Phase 4
27 Effectiveness of Trapeziometacarpal Splint Unknown status NCT02635932 Phase 4
28 Efficacy of Dalfampridine on Upper Extremity Function in Patients With MS Unknown status NCT02259361 Phase 4 Sustained-release oral dalfampridine;Placebo
29 IVIg for Demyelination in Diabetes Mellitus Unknown status NCT02372149 Phase 4 10% intravenous immunoglobulin (IVIg);0.9% sodium chloride
30 Primary Care Study With Chondroitin Sulfate and Glucosamine Hydrochloride in Hand Osteoarhritis Unknown status NCT02823548 Phase 4 Droglican;Placebo
31 Trial on the Ideal Duration of Oral Antibiotics in Children With Pneumonia Unknown status NCT02258763 Phase 4 Amoxicillin-Potassium Clavulanate Combination;Placebo
32 A Study of Residual Curarization Incidence in China Unknown status NCT01690338 Phase 4 Vecuronium Bromide;Rocuronium;Cisatracurium
33 Safety and Immunogenicity of Fluzone® Quadrivalent Vaccine Administered to Healthy Children Completed NCT02915302 Phase 4
34 Immunogenicity and Safety of Fluzone® Quadrivalent, Southern Hemisphere 2015 Formulation (Intramuscular Route) Completed NCT03546192 Phase 4
35 Study to Evaluate the Safety of 1 New 6:2 Influenza Virus Reassortant in Adults for the 2017-2018 Season Completed NCT03158038 Phase 4
36 Randomized Trial of High Dose Influenza Vaccine in Long Term Care Setting Completed NCT01654224 Phase 4
37 Safety and Immunogenicity Among Healthy Children Receiving Fluzone® Quadrivalent, Influenza Vaccine Completed NCT02222870 Phase 4
38 Safety and Immunogenicity of the 2015-2016 Formulation of Fluzone® Quadrivalent (Influenza Vaccine) Among Healthy Children Completed NCT02539108 Phase 4
39 Safety and Immunogenicity of Three Seasonal Trivalent Influenza Vaccines in China Military Completed NCT02640989 Phase 4
40 Study to Evaluate the Safety of 1 New 6:2 Influenza Virus Reassortant in Adults for the 2016-2017 Season Completed NCT02743117 Phase 4
41 A Study of Fluzone® High-Dose Vaccine Compared With Fluzone® Vaccine In Elderly Adults Completed NCT01427309 Phase 4
42 Study to Evaluate the Safety of 3 New 6:2 Influenza Virus Reassortants in Adults for the 2015-2016 Season Completed NCT02473510 Phase 4
43 The Immunologic Basis for an Attenuated Immune Response to the Influenza Vaccine After Repeated Annual Vaccination Completed NCT02876159 Phase 4
44 Influenza Vaccination for Parents and Other Caregivers in the Pediatric Medical Home Completed NCT00812110 Phase 4 Influenzae vaccine
45 Tropical Influenza Control Strategies for the Elderly Completed NCT02655874 Phase 4
46 Maternal Flu Vaccine Trial in Bamako, Mali Completed NCT01430689 Phase 4
47 A Study to Evaluate the Safety and Tolerability of Trivalent Influenza Virus Vaccine in Children Aged 5 Years to < 9 Years Completed NCT02212106 Phase 4
48 Safety and Immunogenicity Among Healthy Children Receiving Fluzone® Quadrivalent Influenza Virus Vaccine Completed NCT01946425 Phase 4
49 The Human Mucosal Immune Responses to Influenza Virus (SLVP026) Completed NCT03023553 Phase 4
50 Inactivated Influenza Via Jet Injection Completed NCT02290691 Phase 4

Search NIH Clinical Center for Influenza

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: influenza, human

Sources

Genetic Tests for Influenza

About this section

Genetic tests related to Influenza:

# Genetic test Affiliating Genes
1 Influenza 29 IFITM3
Sources

Anatomical Context for Influenza

About this section

MalaCards organs/tissues related to Influenza:

41
Testes, T Cells, Lung, B Cells, Heart, Kidney, Bone
Sources

Publications for Influenza

About this section

Articles related to Influenza:

(show top 50) (show all 7901)
# Title Authors Year
1
Stability of retroviral pseudotypes carrying the hemagglutinin of avian influenza viruses under various storage conditions. ( 30347199 )
2019
2
Development of a DAS-ELISA for detection of H9N2 avian influenza virus. ( 30355516 )
2019
3
Vaccination for influenza and pneumococcus in patients with gastrointestinal cancer or inflammatory bowel disease: A prospective cohort study of methods for improving coverage. ( 30485467 )
2019
4
Effectiveness of an educational intervention on seasonal influenza vaccination campaign adherence among healthcare workers of the Palermo University Hospital, Italy. ( 30554237 )
2019
5
Mandatory policies for influenza vaccination: Views of managers and healthcare workers in England. ( 30470641 )
2019
6
Prioritization of risk groups for influenza vaccination in resource limited settings - A case study from South Africa. ( 30471956 )
2019
7
Evolutionary changes of the novel Influenza D virus hemagglutinin-esterase fusion gene revealed by the codon usage pattern. ( 30475085 )
2019
8
Development of a universal influenza vaccine using hemagglutinin stem protein produced from Pichia pastoris. ( 30388628 )
2019
9
Non-chelating p-phenylidene-linked bis-imidazoline analogs of known influenza virus endonuclease inhibitors: Synthesis and anti-influenza activity. ( 30390440 )
2019
10
Lack of IFNγ signaling attenuates spread of influenza A virus in vivo and leads to reduced pathogenesis. ( 30390564 )
2019
11
Canine Influenza Virus A(H3N2) Clade with Antigenic Variation, China, 2016-2017. ( 30407904 )
2019
12
Molecular epidemiology of the hemagglutinin gene of prevalent influenza virus A/H1N1/pdm09 among patient in Iran. ( 30336188 )
2019
13
Self-enzyme chemiluminescence immunoassay capable of rapidly diagnosing the infection of influenza A (H1N1) virus. ( 30348377 )
2019
14
Influenza H5/H7 Virus Vaccination in Poultry and Reduction of Zoonotic Infections, Guangdong Province, China, 2017-18. ( 30355435 )
2019
15
Role of c-Jun terminal kinase (JNK) activation in influenza A virus-induced autophagy and replication. ( 30316042 )
2019
16
Increased influenza-specific antibody avidity in HIV-infected women compared with HIV-infected men on antiretroviral therapy. ( 30234599 )
2019
17
Guava flavonoid glycosides prevent influenza A virus infection via rescue of P53 activity. ( 30153335 )
2019
18
Morphea and Extragenital Lichen Sclerosus et Atrophicus After Influenza Vaccination. ( 29025691 )
2018
19
Analysis of Clinical Manifestations and Laboratory Findings in Children with Influenza B-Associated Myositis: A Single Center Study. ( 29383210 )
2018
20
Detection of influenza myocarditis using national healthcare safety network surveillance definitions accounting for fever in older adults. ( 29945685 )
2018
21
Scoring Amino Acid Mutations to Predict Avian-to-Human Transmission of Avian Influenza Viruses. ( 29966263 )
2018
22
Efficacy of commercial vaccines against newly emerging avian influenza H5N8 virus in Egypt. ( 29946159 )
2018
23
Spanish influenza redux: revisiting the mother of all pandemics. ( 29976462 )
2018
24
Influenza vaccination 2014-2015: Results of a survey conducted among general practitioners in Italy. ( 29451834 )
2018
25
Capillary Leak Syndrome Aggravated by Influenza Type A Infection. ( 29974010 )
2018
26
The PA-interacting host protein nucleolin acts as an antiviral factor during highly pathogenic H5N1 avian influenza virus infection. ( 29974255 )
2018
27
Synergic effect of curcumin and its structural analogue (Monoacetylcurcumin) on anti-influenza virus infection. ( 29976394 )
2018
28
Effects of the S42 residue of the H1N1 swine influenza virus NS1 protein on interferon responses and virus replication. ( 29587786 )
2018
29
Human Infection with Avian Influenza A(H7N2) Virus - Virginia, 2002. ( 29430844 )
2018
30
Immunization rates of pneumococcal, influenza and tetanus vaccines and knowledge and attitudes of adult patients who receive inpatient treatment at hospital: Point prevalence study. ( 29913102 )
2018
31
Extreme heterogeneity of influenza virus infection in single cells. ( 29451492 )
2018
32
Novel Highly Pathogenic Avian Influenza A(H5N6) Virus in the Netherlands, December 2017. ( 29381134 )
2018
33
Emergence of Eurasian Avian-Like Swine Influenza A (H1N1) Virus from an Adult Case in Fujian Province, China. ( 29797225 )
2018
34
Influenza interaction with cocirculating pathogens and its impact on surveillance, pathogenesis, and epidemic profile: A key role for mathematical modelling. ( 29447284 )
2018
35
Pan-Influenza A Protection by Prime-Boost Vaccination with Cold-Adapted Live-Attenuated Influenza Vaccine in a Mouse Model. ( 29449842 )
2018
36
Assessment of human-to-human transmissibility of avian influenza A(H7N9) virus across five waves by analyzing clusters of case-patients in mainland China, 2013-2017. ( 29961834 )
2018
37
Determinants of non-vaccination against seasonal influenza in Canadian adults: findings from the 2015-2016 Influenza Immunization Coverage Survey. ( 29981075 )
2018
38
Maternal Influenza Immunization and Prevention of Severe Clinical Pneumonia in Young Infants: Analysis of Randomized Controlled Trials Conducted in Nepal, Mali, and South Africa. ( 29443825 )
2018
39
Discrimination of Avian Influenza Virus Subtypes using Host-Cell Infection Fingerprinting by a Sulfinate-based Fluorescence Superoxide Probe. ( 29933516 )
2018
40
Spatio-temporal patterns of highly pathogenic avian influenza virus subtype H5N8 spread, France, 2016 to 2017. ( 29970219 )
2018
41
Cost-utility analysis of antiviral use under pandemic influenza using a novel approach - linking pharmacology, epidemiology and heath economics. ( 29446343 )
2018
42
Erratum: Author Correction: Newcastle disease virus-based H5 influenza vaccine protects chickens from lethal challenge with a highly pathogenic H5N2 avian influenza virus. ( 29799537 )
2018
43
Two reassortant types of highly pathogenic H5N8 avian influenza virus from wild birds in Central China in 2016. ( 29410395 )
2018
44
Global avian influenza outbreaks 2010-2016: a systematic review of their distribution, avian species and virus subtype. ( 29368637 )
2018
45
Viral interference between low pathogenic avian influenza H9N2 and avian infectious bronchitis viruses in vitro and in ovo. ( 29940196 )
2018
46
Impact of timing of influenza vaccination in pregnancy on transplacental antibody transfer, influenza incidence and birth outcomes; a randomized trial in rural Nepal. ( 29452372 )
2018
47
Cottontail rabbits shed clade 2.3.4.4 H5 highly pathogenic avian influenza A viruses. ( 29948379 )
2018
48
Acute sialadenitis associated with 2017-2018 influenza A infection: A case series. ( 29658106 )
2018
49
Anti-high mobility group box-1 monoclonal antibody treatment of brain edema induced by influenza infection and lipopolysaccharide. ( 29573352 )
2018
50
Isolation and molecular characterization of an H5N1 swine influenza virus in China in 2015. ( 29164401 )
2018
Sources

Variations for Influenza

About this section

ClinVar genetic disease variations for Influenza:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 IFITM3 NM_021034.2(IFITM3): c.42T> C (p.Ser14=) single nucleotide variant risk factor rs12252 GRCh37 Chromosome 11, 320772: 320772
2 IFITM3 NM_021034.2(IFITM3): c.42T> C (p.Ser14=) single nucleotide variant risk factor rs12252 GRCh38 Chromosome 11, 320772: 320772
Sources

Expression for Influenza

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LifeMap Discovery
Genes differentially expressed in tissues of Influenza patients vs. healthy controls: 35 (show all 45)
# Gene Description Tissue Up/Dn Fold Change (log2) P value
1 IFI27 interferon, alpha-inducible protein 27 Blood + 6.13 0.000
2 OTOF otoferlin Blood + 5.57 0.000
3 KCTD14 potassium channel tetramerization domain containing 14 Blood + 5.45 0.000
4 HESX1 HESX homeobox 1 Blood + 4.33 0.000
5 CMPK2 cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial Blood + 4.32 0.000
6 CCNA1 cyclin A1 Blood + 4.26 0.000
7 METTL7B methyltransferase like 7B Blood + 4.12 0.000
8 C1QC complement component 1, q subcomponent, C chain Blood + 4.11 0.000
9 OLFM4 olfactomedin 4 Blood + 3.99 0.000
10 SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin Blood + 3.98 0.000
11 OLFM1 olfactomedin 1 Blood - 3.92 0.000
12 RSAD2 radical S-adenosyl methionine domain containing 2 Blood + 3.86 0.000
13 GPR42 G protein-coupled receptor 42 (gene/pseudogene) Blood + 3.85 0.000
14 RNASE1 ribonuclease, RNase A family, 1 (pancreatic) Blood + 3.83 0.000
15 CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) Blood + 3.80 0.000
16 KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1 Blood + 3.73 0.000
17 OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa Blood + 3.70 0.000
18 TMEM119 transmembrane protein 119 Blood + 3.66 0.000
19 DNAAF1 dynein, axonemal, assembly factor 1 Blood + 3.54 0.000
20 HP haptoglobin Blood + 3.46 0.000
21 PRSS33 protease, serine, 33 Blood - 3.42 0.000
22 IFI44L interferon-induced protein 44-like Blood + 3.42 0.000
23 PPARG peroxisome proliferator-activated receptor gamma Blood + 3.38 0.000
24 PID1 phosphotyrosine interaction domain containing 1 Blood - 3.37 0.000
25 SLC26A8 solute carrier family 26 (anion exchanger), member 8 Blood + 3.37 0.000
26 IFITM4P interferon induced transmembrane protein 4 pseudogene Blood + 3.31 0.000
27 CNTNAP2 contactin associated protein-like 2 Blood - 3.30 0.000
28 PTGDR2 prostaglandin D2 receptor 2 Blood - 3.28 0.000
29 IFIT1 interferon-induced protein with tetratricopeptide repeats 1 Blood + 3.28 0.000
30 GPR84 G protein-coupled receptor 84 Blood + 3.25 0.000
31 CACNG6 calcium channel, voltage-dependent, gamma subunit 6 Blood - 3.22 0.000
32 IL27 interleukin 27 Blood + 3.21 0.000
33 SYN2 synapsin II Blood + 3.20 0.000
34 OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa Blood + 3.19 0.000
35 MATK megakaryocyte-associated tyrosine kinase Blood - 3.18 0.000
36 HIST1H4D histone cluster 1, H4d Blood + 3.16 0.000
37 OLIG2 oligodendrocyte lineage transcription factor 2 Blood - 3.15 0.000
38 ISG15 ISG15 ubiquitin-like modifier Blood + 3.11 0.000
39 IFIT3 interferon-induced protein with tetratricopeptide repeats 3 Blood + 3.09 0.000
40 EXOC3L1 exocyst complex component 3-like 1 Blood + 3.09 0.000
41 RSPH9 radial spoke head 9 homolog (Chlamydomonas) Blood + 3.08 0.000
42 CD177 CD177 molecule Blood + 3.04 0.000
43 TCN2 transcobalamin II Blood + 3.03 0.000
44 IFI44 interferon-induced protein 44 Blood + 3.03 0.000
45 PLSCR1 phospholipid scramblase 1 Blood + 3.01 0.000
Search GEO for disease gene expression data for Influenza.
Sources

Pathways for Influenza

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Pathways related to Influenza according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 66
Show member pathways