Home
User Guide
What's in a MalaCard Search Guide Our Sources
Analysis Tools
GeneCards GeneAnalytics GeneAlaCart PathCards VarElect TGex
News and Views Disease Lists/Categories
About
About MalaCards Our Publications Academic Licensing Weizmann Institute LifeMap Discovery® Terms of Use MalaCards Team
MCID: INF038
MIFTS: 76

Influenza

Categories: Respiratory diseases, Infectious diseases, Genetic diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
Sources

Aliases & Classifications for Influenza

About this section

MalaCards integrated aliases for Influenza:

Name: Influenza 12 76 29 55 6 3 3 15 73
Flu 12 43 3 63
Influenza with Non-Respiratory Manifestation 12
Influenza with Other Manifestations 12
Influenza, Susceptibility to 40
Influenza, Human 44

Classifications:

MalaCards categories:
Global: Infectious diseases Genetic diseases
Anatomical: Respiratory diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:8469
ICD9CM 35 487
MeSH 44 D007251
NCIt 50 C53482
UMLS 73 C0021400
Sources

Summaries for Influenza

About this section
MedlinePlus : 43 Flu is a respiratory infection caused by a number of viruses. The viruses pass through the air and enter your body through your nose or mouth. Between 5% and 20% of people in the U.S. get the flu each year. The flu can be serious or even deadly for elderly people, newborn babies, and people with certain chronic illnesses. Symptoms of the flu come on suddenly and are worse than those of the common cold. They may include Body or muscle aches Chills Cough Fever Headache Sore throat Is it a cold or the flu? Colds rarely cause a fever or headaches. Flu almost never causes an upset stomach. And "stomach flu" isn't really flu at all, but gastroenteritis. Most people with the flu recover on their own without medical care. People with mild cases of the flu should stay home and avoid contact with others, except to get medical care. If you get the flu, your health care provider may prescribe medicine to help your body fight the infection and lessen symptoms. The main way to keep from getting the flu is to get a yearly flu vaccine. Good hygiene, including hand washing, can also help. NIH: National Institute of Allergy and Infectious Diseases

MalaCards based summary : Influenza, also known as flu, is related to avian influenza and newcastle disease, and has symptoms including coughing, fever and pruritus. An important gene associated with Influenza is IFITM3 (Interferon Induced Transmembrane Protein 3), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Tequin and Lidocaine have been mentioned in the context of this disorder. Affiliated tissues include testes, lung and brain.

Disease Ontology : 12 A viral infectious disease that results in infection, located in respiratory tract, has material basis in Influenzavirus A, has material basis in Influenzavirus B, or has material basis in Influenzavirus C, which are transmitted by droplet spread of oronasal secretions during coughing, sneezing, or talking from an infected person. It is a highly contagious disease that affects birds and mammals and has symptom chills, has symptom fever, has symptom sore throat, has symptom runny nose, has symptom muscle pains, has symptom severe headache, has symptom cough, and has symptom weakness.

CDC : 3 Influenza Updates:

PubMed Health : 63 About flu: People often talk about having the flu (influenza) when they come down with a cold. Yet the course of these two illnesses is very different and they also typically have different signs and symptoms.Colds are much more common than the flu. They also start quite slowly, while the viruses that cause the flu strike quickly and cause more severe symptoms – even in people who are otherwise quite healthy. The flu makes you feel very ill quite suddenly. Colds don't usually cause any serious harm, and are often over within a week, with or without treatment. It is a good idea to see a doctor if you have the flu, and it may take some time before you fully recover.But colds and the flu do have one thing in common: The treatment for both focuses on relieving the symptoms. The only medicines that target the flu viruses directly can at most reduce the time you are ill. But a number of things can be done to avoid infection in the first place.

Wikipedia : 76 Influenza, commonly known as \"the flu\", is an infectious disease caused by an influenza virus.... more...

Sources

Related Diseases for Influenza

About this section

Diseases in the Influenza family:

Influenza, Severe

Diseases related to Influenza via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 509)
# Related Disease Score Top Affiliating Genes
1 avian influenza 34.9 DDX58 FURIN IRF7
2 newcastle disease 31.5 DDX58 IFNA1 IRF7
3 stomatitis 30.9 DDX58 IFITM3 IFNA1
4 severe acute respiratory syndrome 30.6 IFNA1 IFNG TMPRSS2
5 measles 30.5 DDX58 IFNA1 IFNG
6 rift valley fever 30.3 IFITM3 MX1
7 mouth disease 30.3 IFNA1 IFNG MX1
8 west nile virus 30.2 DDX58 IFITM3 IFNA1 MX1
9 viral infectious disease 30.2 DDX58 IFNA1 IFNG IRF7 ISG15 MX1
10 hepatitis c 29.6 DDX58 IFNA1 IFNG IRF7
11 swine influenza 12.6
12 haemophilus influenzae 12.5
13 influenza, severe 12.0
14 viral pneumonia 11.4
15 haemophilus meningitis 11.3
16 acute necrotizing encephalopathy 11.3
17 encephalopathy, acute, infection-induced 4 11.2
18 epiglottitis 11.2
19 common cold 11.1
20 lung disease 11.1
21 croup 11.1
22 human immunodeficiency virus type 1 11.1
23 acute diarrhea 11.1
24 acquired immunodeficiency syndrome 11.1
25 specific antibody deficiency 10.9
26 complement component 3 deficiency, autosomal recessive 10.8
27 immunodeficiency 39 10.8
28 pontiac fever 10.8
29 ross river fever 10.8
30 haverhill fever 10.8
31 gastroenteritis 10.8
32 white matter hypoplasia-corpus callosum agenesis-intellectual disability syndrome 10.8
33 mda5 deficiency 10.8
34 microphthalmia with limb anomalies 10.8 IFNA1 ISG15 MX1
35 bronchitis 10.6
36 pneumonia 10.5
37 relapsing-remitting multiple sclerosis 10.5 IFNA1 IFNG MX1
38 bronchopneumonia 10.5
39 anaerobic pneumonia 10.5
40 tetanus 10.4
41 ornithosis 10.3
42 pertussis 10.3
43 pericardial tuberculosis 10.3 IFNG TRIM25
44 diphtheria 10.3
45 aging 10.3
46 hepatitis 10.2
47 meningitis 10.2
48 eczema herpeticum 10.2 IFNG IRF7
49 hepatitis b 10.2
50 otitis media 10.1

Graphical network of the top 20 diseases related to Influenza:



Diseases related to Influenza
Sources

Symptoms & Phenotypes for Influenza

About this section

UMLS symptoms related to Influenza:


coughing, fever, pruritus, snoring, influenza-like symptoms, fever, catarrhal, acute, symptoms
Sources

Drugs & Therapeutics for Influenza

About this section

PubMedHealth treatment related to Influenza: 63

Many people turn to home remedies like chicken broth and herbal teas to relieve flu symptoms. And getting plenty to drink is also considered to be important. But there is no scientific proof that any of these things helps speed up recovery. So you don't necessarily need to rely on any of the remedies or to drink more fluids than you feel like.A number of freely available products like vitamin supplements or inhalation devices are marketed for the treatment of colds, flus and coughs. But there is no compelling evidence that they are effective against the flu. Painkillers such as acetaminophen (paracetamol), acetylsalicylic acid (ASA, the drug in medicines like Aspirin) and ibuprofen can relieve pain and lower fever. But children and teenagers should not take ASA because in rare cases this drug can cause a serious brain condition in these age groups.In addition to over-the-counter products, prescription-only medication is also available. The most common of these in Germany is oseltamivir (trade name: Tamiflu). Oseltamivir is prescription-only and needs to be taken within two days after the flu starts. It does not have any effect on the course of the flu infection if you have already had symptoms for longer. Some research suggests that oseltamivir could reduce the period of illness by up to one day. But it often causes nausea and vomiting. It is not clear that it helps to prevent complications. Some people think that antibiotics will help in the treatment of flu. But antibiotics are only effective against bacteria, not against viruses. So antibiotics only help if you have a bacterial infection of the airways as well as a viral infection. Unless there are signs of bacterial infection, there is no point in taking antibiotics.

FDA approved drugs:

# Drug Name Active Ingredient(s) 18 Company Approval Date
1
Tequin 18 Bristol-Myers Squibb December, 1999

Drugs for Influenza (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 924)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lidocaine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 137-58-6 3676
2
Fludarabine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 21679-14-1, 75607-67-9 30751
3
Ribavirin Approved Phase 4,Phase 3,Phase 2,Phase 1 36791-04-5 37542
4
Infliximab Approved Phase 4,Phase 3,Phase 2,Not Applicable 170277-31-3
5
Heparin Approved, Investigational Phase 4,Phase 3 9005-49-6 772 46507594
6
Iron Approved Phase 4,Phase 3,Phase 2,Not Applicable 7439-89-6 23925
7
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 51-61-6, 62-31-7 681
8
Azelastine Approved Phase 4,Phase 1 58581-89-8 2267
9
Acetylcholine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 51-84-3 187
10
Ephedrine Approved Phase 4,Phase 3,Phase 1 299-42-3 9294
11
Pseudoephedrine Approved Phase 4,Phase 3,Phase 1 90-82-4 7028
12
Atracurium Approved, Experimental, Investigational Phase 4 64228-79-1 47319
13
Methotrexate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1959-05-2, 59-05-2 126941
14
Phenylephrine Approved Phase 4,Phase 3,Phase 1 59-42-7 6041
15
4-Aminopyridine Approved Phase 4,Phase 3,Phase 2,Phase 1 504-24-5 1727
16
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 22916-47-8 4189
17
Morphine Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 57-27-2 5288826
18
Oseltamivir Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 204255-11-8, 196618-13-0 65028
19
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
20
Formaldehyde Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 50-00-0 712
21
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 50-18-0, 6055-19-2 2907
22
Calcium Carbonate Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 471-34-1
23
Triamcinolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 124-94-7 31307
24
Busulfan Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 55-98-1 2478
25
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-24-8 5755
26
Acetaminophen Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 103-90-2 1983
27
Amoxicillin Approved, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 26787-78-0 33613
28
Tacrolimus Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 104987-11-3 445643 439492
29
Cisatracurium Approved Phase 4 96946-41-7
30
Histamine Approved, Investigational Phase 4,Phase 3,Phase 1,Not Applicable 75614-87-8, 51-45-6 774
31
Mycophenolic acid Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 24280-93-1 446541
32
Adalimumab Approved Phase 4,Phase 3,Phase 2 331731-18-1 16219006
33
Oxymetazoline Approved, Investigational Phase 4,Phase 3,Phase 1 1491-59-4 4636
34
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 1994-09-7, 94-09-7 2337
35
Mycophenolate mofetil Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 128794-94-5 5281078
36
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 83-43-2 6741
37
Peginterferon alfa-2a Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 198153-51-4 5360545
38
Fluticasone Approved, Experimental, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 90566-53-3 62924
39
Guaifenesin Approved, Investigational, Vet_approved Phase 4,Phase 3,Not Applicable 93-14-1 3516
40
Ticlopidine Approved Phase 4 55142-85-3 5472
41
rituximab Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 174722-31-7 10201696
42
Clopidogrel Approved Phase 4 120202-66-6, 113665-84-2 60606
43
Zanamivir Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 139110-80-8 60855
44
Remifentanil Approved Phase 4 132875-61-7 60815
45
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
46
Azithromycin Approved Phase 4,Phase 3,Phase 2 83905-01-5 55185 447043
47
Moxifloxacin Approved, Investigational Phase 4,Phase 1 354812-41-2, 151096-09-2 152946
48
Norepinephrine Approved Phase 4 51-41-2 439260
49
Fluconazole Approved, Investigational Phase 4,Phase 3,Phase 2 86386-73-4 3365
50 Estradiol valerate Approved, Investigational, Vet_approved Phase 4,Phase 1 979-32-8

Interventional clinical trials:

(show top 50) (show all 4385)
# Name Status NCT ID Phase Drugs
1 The Effect and Safety of the Seasonal Trivalent Influenza Vaccine in Chronic Kidney Disease Patients Not on Dialysis Unknown status NCT02105519 Phase 4
2 Effect of HIV and/or Active Tuberculosis on the Immune Responses to Trivalent Influenza Vaccine (TIV) in Adults Unknown status NCT01811823 Phase 4
3 Safety and Efficacy of Intradermal Trivalent Influenza Vaccination in Institutionalized Older Adults Unknown status NCT01967368 Phase 4 Intanza;Vaxigrip
4 Optimizing Influenza Vaccination in Surgical Oncology Patients Unknown status NCT01698177 Phase 4
5 A Study of Arbidol (Umifenovir) for Treatment and Prophylaxis of Influenza and Common Cold Unknown status NCT01651663 Phase 4 Arbidol (Umifenovir);Arbidol (Umifenovir)
6 Study of Immune Responses After Vaccination Against Seasonal Influenza Virus and Against Influenza H1N1-v Pandemic Virus in a Medical Staff. Unknown status NCT01063608 Phase 4
7 Banlangen Granules Anti-seasonal Influenza Study Unknown status NCT02232945 Phase 4 placebo of oseltamivir phosphate;oseltamivir phosphate;Banlangen (Radix Isatidis) granules;placebo of Banlangen(Radix Isatidis) granules
8 Influenza Vaccination in Patients With Scleroderma Unknown status NCT01002508 Phase 4
9 Comparison of the Cellular and the Humoral Immunogenicity, Safety of Different Trivalent Influenza Vaccines Unknown status NCT01119157 Phase 4
10 Immunogenicity and Safety of a Trivalent Inactivated Influenza Vaccine,Formulation 2011-2012, in Dialysis Patients Unknown status NCT01512056 Phase 4 AdimFlu-S
11 Immunogenicity of Influenza Vaccines in HIV-infected Persons in Thailand Unknown status NCT01538940 Phase 4
12 Cell Immunity Response to Vaccination Against Influenza in Patients With Rheumatoid Arthritis Unknown status NCT01002716 Phase 4
13 A Randomised Controlled Trial on the Effect of Post-exposure Oseltamivir Prophylaxis on Influenza Transmission in Nursing Homes Unknown status NCT01053377 Phase 4 Tamiflu (verum);Tamiflu placebo
14 VAccination to Improve Clinical outComes in Heart Failure Trial: a Feasibility Study (VACC-HeFT) Unknown status NCT02268500 Phase 4
15 Chinese Medicinal Herbs Treatment on Novel Influenza A (H1N1)Pneumonia: Multi-centre, Prospective, Randomized Controlled Study Unknown status NCT00936013 Phase 4 oseltamivir;oseltamivir and chinese medicinal herbs
16 The Impact of Vitamin on the Clinical Course in Cases Infected by Novel H1N1 Influenza Virus A Unknown status NCT01127282 Phase 4 Vitamin (vitamin A 15 mg,C 500 mg, E 400IU);Placebo (digestive tablet)
17 Seasonal Influenza Vaccine, Quadrivalent Versus Trivalent in Patients With Advanced Chronic Obstructive Pulmonary Disease Unknown status NCT02563184 Phase 4
18 Effect of Tocilizumab to the Cellular Immune Response to Influenza Vaccine Unknown status NCT01980836 Phase 4
19 Immune Response Analysis to Influenza Vaccine in Elderly Aged Over 65 Years Unknown status NCT01289535 Phase 4
20 Safety and Immune Response to Adjuvanted A(H1N1)v Influenza Vaccine in HIV-1 Infected and Immunosuppressed Adult Patients Unknown status NCT01017172 Phase 4
21 Safety and Efficacy of Anti-Pandemic H1N1 Vaccination in Rheumatic Diseases Unknown status NCT01151644 Phase 4
22 AZELASTINE/FLUTICASONE (AZE/FLU) Nasal Spray on Symptom Control, Nasal Mediators and Nasal Hyperresponsiveness in Allergic Rhinitis (AR) Unknown status NCT02238353 Phase 4 azelastine + fluticasone;Placebo
23 Comparing Treatment Efficacy With HD/MD Flu Plus Sal in Chronic Obstructive Pulmonary Disease (COPD) Patients Unknown status NCT01131806 Phase 4 fluticasone/ salmeterol 125/25 mcg/puff;fluticasone/ salmeterol 250/25 mcg/puff
24 Body Composition Measurements in Chronic Heart Failure Unknown status NCT02686866 Phase 4
25 Corticosteroid Injection Verses High Energy Extracorporeal Shock Wave Therapy for Lateral Epicondylitis Unknown status NCT02613455 Phase 4 Kenalog (triamcinolone);lidocaine 1% (lidocaine HCl 20mg)
26 Middle Meatal Bacteriology During Acute Respiratory Infection in Children Unknown status NCT00545961 Phase 4 placebo;amoxicillin clavulanate acid
27 Safety, Long Term Immunogenicity and Lot Consistency Study of Liquid Pentavalent Combination Vaccine Unknown status NCT00877357 Phase 4
28 Effectiveness of Trapeziometacarpal Splint Unknown status NCT02635932 Phase 4
29 Efficacy of Dalfampridine on Upper Extremity Function in Patients With MS Unknown status NCT02259361 Phase 4 Sustained-release oral dalfampridine;Placebo
30 A Study of Residual Curarization Incidence in China Unknown status NCT01690338 Phase 4 Vecuronium Bromide;Rocuronium;Cisatracurium
31 Safety and Immunogenicity of Fluzone® Quadrivalent Vaccine Administered to Healthy Children Completed NCT02915302 Phase 4
32 Study to Evaluate the Safety of 1 New 6:2 Influenza Virus Reassortant in Adults for the 2017-2018 Season Completed NCT03158038 Phase 4
33 Study to Evaluate the Safety of 1 New 6:2 Influenza Virus Reassortant in Adults for the 2016-2017 Season Completed NCT02743117 Phase 4
34 Safety and Immunogenicity Among Healthy Children Receiving Fluzone® Quadrivalent, Influenza Vaccine Completed NCT02222870 Phase 4
35 Safety and Immunogenicity of Three Seasonal Trivalent Influenza Vaccines in China Military Completed NCT02640989 Phase 4
36 Safety and Immunogenicity of the 2015-2016 Formulation of Fluzone® Quadrivalent (Influenza Vaccine) Among Healthy Children Completed NCT02539108 Phase 4
37 Study to Evaluate the Safety of 3 New 6:2 Influenza Virus Reassortants in Adults for the 2015-2016 Season Completed NCT02473510 Phase 4
38 Randomized Trial of High Dose Influenza Vaccine in Long Term Care Setting Completed NCT01654224 Phase 4
39 Tropical Influenza Control Strategies for the Elderly Completed NCT02655874 Phase 4
40 The Human Mucosal Immune Responses to Influenza Virus (SLVP026) Completed NCT03023553 Phase 4
41 A Study to Evaluate the Safety and Tolerability of Trivalent Influenza Virus Vaccine in Children Aged 5 Years to < 9 Years Completed NCT02212106 Phase 4
42 Inactivated Influenza Via Jet Injection Completed NCT02290691 Phase 4
43 Safety and Immunogenicity of Fluzone® Quadrivalent and Fluzone® High-Dose, Influenza Vaccines, 2016-2017 Formulations Completed NCT02908269 Phase 4
44 Immunogenicity and Safety of Fluzone® Quadrivalent, Southern Hemisphere 2015 Formulation (Intramuscular Route) Completed NCT03546192 Phase 4
45 B-cell Immunity to Influenza (SLVP017) - Years 2 (2010) & 3 (2011) Completed NCT03020498 Phase 4
46 A Study of Fluzone® High-Dose Vaccine Compared With Fluzone® Vaccine In Elderly Adults Completed NCT01427309 Phase 4
47 B-cell Immunity to Influenza (SLVP017)- Year 1, 2009 Completed NCT02133781 Phase 4
48 Efficacy & Safety of Nasal Influenza Immunisation in Children Completed NCT02549365 Phase 4 Live attenuated influenza vaccine
49 Safety and Immunogenicity Among Healthy Children Receiving Fluzone® Quadrivalent Influenza Virus Vaccine Completed NCT01946425 Phase 4
50 Self-Administered Nasal Influenza Feasibility Study Completed NCT01933048 Phase 4 FluMist

Search NIH Clinical Center for Influenza

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: influenza, human

Sources

Genetic Tests for Influenza

About this section

Genetic tests related to Influenza:

# Genetic test Affiliating Genes
1 Influenza 29 IFITM3
Sources

Anatomical Context for Influenza

About this section

MalaCards organs/tissues related to Influenza:

41
Testes, Lung, Brain, Bone, T Cells, Heart, Kidney
Sources

Publications for Influenza

About this section

Articles related to Influenza:

(show top 50) (show all 5064)
# Title Authors Year
1
Morphea and Extragenital Lichen Sclerosus et Atrophicus After Influenza Vaccination. ( 29025691 )
2018
2
Analysis of Clinical Manifestations and Laboratory Findings in Children with Influenza B-Associated Myositis: A Single Center Study. ( 29383210 )
2018
3
Detection of influenza myocarditis using national healthcare safety network surveillance definitions accounting for fever in older adults. ( 29945685 )
2018
4
Scoring Amino Acid Mutations to Predict Avian-to-Human Transmission of Avian Influenza Viruses. ( 29966263 )
2018
5
Efficacy of commercial vaccines against newly emerging avian influenza H5N8 virus in Egypt. ( 29946159 )
2018
6
Spanish influenza redux: revisiting the mother of all pandemics. ( 29976462 )
2018
7
Influenza vaccination 2014-2015: Results of a survey conducted among general practitioners in Italy. ( 29451834 )
2018
8
Capillary Leak Syndrome Aggravated by Influenza Type A Infection. ( 29974010 )
2018
9
The PA-interacting host protein nucleolin acts as an antiviral factor during highly pathogenic H5N1 avian influenza virus infection. ( 29974255 )
2018
10
Nontypeable Haemophilus influenzae DNA stimulates type I interferon expression via STING signaling pathway. ( 29421524 )
2018
11
Synergic effect of curcumin and its structural analogue (Monoacetylcurcumin) on anti-influenza virus infection. ( 29976394 )
2018
12
Mutant selection window of four quinolone antibiotics against clinical isolates of Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis. ( 29290527 )
2018
13
Effects of the S42 residue of the H1N1 swine influenza virus NS1 protein on interferon responses and virus replication. ( 29587786 )
2018
14
Nontypeable Haemophilus Influenzae Sepsis in a Term Neonate. ( 29955021 )
2018
15
Human Infection with Avian Influenza A(H7N2) Virus - Virginia, 2002. ( 29430844 )
2018
16
Immunization rates of pneumococcal, influenza and tetanus vaccines and knowledge and attitudes of adult patients who receive inpatient treatment at hospital: Point prevalence study. ( 29913102 )
2018
17
Extreme heterogeneity of influenza virus infection in single cells. ( 29451492 )
2018
18
Single nucleotide polymorphisms in genes encoding penicillin-binding proteins in I^-lactamase-negative ampicillin-resistant Haemophilus influenzae in Japan. ( 29352811 )
2018
19
Novel Highly Pathogenic Avian Influenza A(H5N6) Virus in the Netherlands, December 2017. ( 29381134 )
2018
20
Emergence of Eurasian Avian-Like Swine Influenza A (H1N1) Virus from an Adult Case in Fujian Province, China. ( 29797225 )
2018
21
Carbapenem-non-Susceptible <i>Haemophilus influenzae</i> with Penicillin-Binding Protein 3 containing Amino Acid Insertion. ( 29784853 )
2018
22
Long-term exposure to low-dose <i>Haemophilus influenzae</i> during allergic airway disease drives a steroid-resistant neutrophilic inflammation and promotes airway remodeling. ( 29861841 )
2018
23
Influenza interaction with cocirculating pathogens and its impact on surveillance, pathogenesis, and epidemic profile: A key role for mathematical modelling. ( 29447284 )
2018
24
Immunologic non-inferiority and safety of the investigational pneumococcal non-typeable Haemophilus influenzae protein D-conjugate vaccine (PHiD-CV) 4-dose vial presentation compared to the licensed PHiD-CV 1-dose vial presentation in infants: A phase III randomized study. ( 29277353 )
2018
25
Pan-Influenza A Protection by Prime-Boost Vaccination with Cold-Adapted Live-Attenuated Influenza Vaccine in a Mouse Model. ( 29449842 )
2018
26
Assessment of human-to-human transmissibility of avian influenza A(H7N9) virus across five waves by analyzing clusters of case-patients in mainland China, 2013-2017. ( 29961834 )
2018
27
Determinants of non-vaccination against seasonal influenza in Canadian adults: findings from the 2015-2016 Influenza Immunization Coverage Survey. ( 29981075 )
2018
28
Maternal Influenza Immunization and Prevention of Severe Clinical Pneumonia in Young Infants: Analysis of Randomized Controlled Trials Conducted in Nepal, Mali, and South Africa. ( 29443825 )
2018
29
Discrimination of Avian Influenza Virus Subtypes using Host-Cell Infection Fingerprinting by a Sulfinate-based Fluorescence Superoxide Probe. ( 29933516 )
2018
30
Spatio-temporal patterns of highly pathogenic avian influenza virus subtype H5N8 spread, France, 2016 to 2017. ( 29970219 )
2018
31
Cost-utility analysis of antiviral use under pandemic influenza using a novel approach - linking pharmacology, epidemiology and heath economics. ( 29446343 )
2018
32
Erratum: Author Correction: Newcastle disease virus-based H5 influenza vaccine protects chickens from lethal challenge with a highly pathogenic H5N2 avian influenza virus. ( 29799537 )
2018
33
Two reassortant types of highly pathogenic H5N8 avian influenza virus from wild birds in Central China in 2016. ( 29410395 )
2018
34
Global avian influenza outbreaks 2010-2016: a systematic review of their distribution, avian species and virus subtype. ( 29368637 )
2018
35
Viral interference between low pathogenic avian influenza H9N2 and avian infectious bronchitis viruses in vitro and in ovo. ( 29940196 )
2018
36
Impact of timing of influenza vaccination in pregnancy on transplacental antibody transfer, influenza incidence and birth outcomes; a randomized trial in rural Nepal. ( 29452372 )
2018
37
Cottontail rabbits shed clade 2.3.4.4 H5 highly pathogenic avian influenza A viruses. ( 29948379 )
2018
38
Acute sialadenitis associated with 2017-2018 influenza A infection: A case series. ( 29658106 )
2018
39
Anti-high mobility group box-1 monoclonal antibody treatment of brain edema induced by influenza infection and lipopolysaccharide. ( 29573352 )
2018
40
Isolation and molecular characterization of an H5N1 swine influenza virus in China in 2015. ( 29164401 )
2018
41
Cardiogenic Shock: A Rare Complication of Influenza. ( 29963343 )
2018
42
Influenza B-related meningoencephalitis in adults. ( 29930187 )
2018
43
Electrostatic Variation of Haemagglutinin as a Hallmark of the Evolution of Avian Influenza Viruses. ( 29386534 )
2018
44
Prolonged evolution of virus-specific memory T cell immunity post severe avian influenza A (H7N9) virus infection. ( 29925664 )
2018
45
Spontaneous remission of adult-onset minimal change nephrotic syndrome associated with influenza B infection: a case report. ( 29973143 )
2018
46
Non-mumps Viral Parotitis During the 2014-2015 Influenza Season in the United States. ( 29617951 )
2018
47
Pneumococcal phenotype and interaction with nontypeable<i>Haemophilus influenzae</i>as determinants of otitis media progression. ( 29378791 )
2018
48
Effects of Isatis root polysaccharide in mice infected with H3N2 swine influenza virus. ( 29890386 )
2018
49
Swine influenza viruses in Northern Vietnam in 2013-2014. ( 29967457 )
2018
50
Hemorrhagic encephalitis associated with H3N2 influenza A viral pneumonia. ( 29440541 )
2018
Sources

Variations for Influenza

About this section

ClinVar genetic disease variations for Influenza:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 IFITM3 NM_021034.2(IFITM3): c.42T> C (p.Ser14=) single nucleotide variant risk factor rs12252 GRCh37 Chromosome 11, 320772: 320772
2 IFITM3 NM_021034.2(IFITM3): c.42T> C (p.Ser14=) single nucleotide variant risk factor rs12252 GRCh38 Chromosome 11, 320772: 320772
Sources

Expression for Influenza

About this section
LifeMap Discovery
Genes differentially expressed in tissues of Influenza patients vs. healthy controls: 35 (show all 45)
# Gene Description Tissue Up/Dn Fold Change (log2) P value
1 IFI27 interferon, alpha-inducible protein 27 Blood + 6.13 0.000
2 OTOF otoferlin Blood + 5.57 0.000
3 KCTD14 potassium channel tetramerization domain containing 14 Blood + 5.45 0.000
4 HESX1 HESX homeobox 1 Blood + 4.33 0.000
5 CMPK2 cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial Blood + 4.32 0.000
6 CCNA1 cyclin A1 Blood + 4.26 0.000
7 METTL7B methyltransferase like 7B Blood + 4.12 0.000
8 C1QC complement component 1, q subcomponent, C chain Blood + 4.11 0.000
9 OLFM4 olfactomedin 4 Blood + 3.99 0.000
10 SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin Blood + 3.98 0.000
11 OLFM1 olfactomedin 1 Blood - 3.92 0.000
12 RSAD2 radical S-adenosyl methionine domain containing 2 Blood + 3.86 0.000
13 GPR42 G protein-coupled receptor 42 (gene/pseudogene) Blood + 3.85 0.000
14 RNASE1 ribonuclease, RNase A family, 1 (pancreatic) Blood + 3.83 0.000
15 CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) Blood + 3.80 0.000
16 KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1 Blood + 3.73 0.000
17 OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa Blood + 3.70 0.000
18 TMEM119 transmembrane protein 119 Blood + 3.66 0.000
19 DNAAF1 dynein, axonemal, assembly factor 1 Blood + 3.54 0.000
20 HP haptoglobin Blood + 3.46 0.000
21 PRSS33 protease, serine, 33 Blood - 3.42 0.000
22 IFI44L interferon-induced protein 44-like Blood + 3.42 0.000
23 PPARG peroxisome proliferator-activated receptor gamma Blood + 3.38 0.000
24 PID1 phosphotyrosine interaction domain containing 1 Blood - 3.37 0.000
25 SLC26A8 solute carrier family 26 (anion exchanger), member 8 Blood + 3.37 0.000
26 IFITM4P interferon induced transmembrane protein 4 pseudogene Blood + 3.31 0.000
27 CNTNAP2 contactin associated protein-like 2 Blood - 3.30 0.000
28 PTGDR2 prostaglandin D2 receptor 2 Blood - 3.28 0.000
29 IFIT1 interferon-induced protein with tetratricopeptide repeats 1 Blood + 3.28 0.000
30 GPR84 G protein-coupled receptor 84 Blood + 3.25 0.000
31 CACNG6 calcium channel, voltage-dependent, gamma subunit 6 Blood - 3.22 0.000
32 IL27 interleukin 27 Blood + 3.21 0.000
33 SYN2 synapsin II Blood + 3.20 0.000
34 OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa Blood + 3.19 0.000
35 MATK megakaryocyte-associated tyrosine kinase Blood - 3.18 0.000
36 HIST1H4D histone cluster 1, H4d Blood + 3.16 0.000
37 OLIG2 oligodendrocyte lineage transcription factor 2 Blood - 3.15 0.000
38 ISG15 ISG15 ubiquitin-like modifier Blood + 3.11 0.000
39 IFIT3 interferon-induced protein with tetratricopeptide repeats 3 Blood + 3.09 0.000
40 EXOC3L1 exocyst complex component 3-like 1 Blood + 3.09 0.000
41 RSPH9 radial spoke head 9 homolog (Chlamydomonas) Blood + 3.08 0.000
42 CD177 CD177 molecule Blood + 3.04 0.000
43 TCN2 transcobalamin II Blood + 3.03 0.000
44 IFI44 interferon-induced protein 44 Blood + 3.03 0.000
45 PLSCR1 phospholipid scramblase 1 Blood + 3.01 0.000
Search GEO for disease gene expression data for Influenza.
Sources

Pathways for Influenza

About this section

Pathways related to Influenza according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 66
Show member pathways
 13.87 DDX58 DNAJC3 IFITM3 IFNA1 IFNG IRF7
2
Cytokine Signaling in Immune system 66
Show member pathways
 13.01 DDX58 IFITM3 IFNA1 IFNG IRF7 ISG15
3
Transport of the SLBP independent Mature mRNA 66
Show member pathways
 12.99 CPSF4 DDX58 ISG15 KPNA3 MX1 MX2
4
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways 66
Show member pathways
 12.6 DDX58 IFNA1 IFNG IRF7 ISG15 TRIM25
5
Influenza Viral RNA Transcription and Replication 66
Show member pathways
 12.56 CPSF4 DNAJC3 ISG15 KPNA3 RANBP2 XPO1
6
Influenza A 37
Show member pathways
 12.42 CPSF4 DDX58 DNAJC3 FURIN IFNA1 IFNG
7
Regulation of IFNA signaling 66
Show member pathways
 12.4 IFITM3 IFNA1 IFNG IRF7 ISG15 MX1
8
NF-kappaB Signaling 4
12.39 DDX58