MCID: INF136
MIFTS: 15

Influenza, Severe

Categories: Genetic diseases, Infectious diseases, Respiratory diseases

Aliases & Classifications for Influenza, Severe

MalaCards integrated aliases for Influenza, Severe:

Name: Influenza, Severe 57
Influenza, Severe, Susceptibility to 57 13

Classifications:



External Ids:

OMIM® 57 614680

Summaries for Influenza, Severe

MalaCards based summary : Influenza, Severe, also known as influenza, severe, susceptibility to, is related to influenza. An important gene associated with Influenza, Severe is IFITM3 (Interferon Induced Transmembrane Protein 3). The drugs Oseltamivir and Antiviral Agents have been mentioned in the context of this disorder.

More information from OMIM: 614680

Related Diseases for Influenza, Severe

Diseases in the Influenza family:

Influenza, Severe

Diseases related to Influenza, Severe via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 influenza 10.0

Symptoms & Phenotypes for Influenza, Severe

Clinical features from OMIM®:

614680 (Updated 05-Apr-2021)

Drugs & Therapeutics for Influenza, Severe

Drugs for Influenza, Severe (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Oseltamivir Approved 204255-11-8, 196618-13-0 65028
2 Antiviral Agents
3 Anti-Infective Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Monitoring Influenza Severity on Tamiflu (MIST) Completed NCT00555893 Oseltamivir;Placebo

Search NIH Clinical Center for Influenza, Severe

Genetic Tests for Influenza, Severe

Anatomical Context for Influenza, Severe

Publications for Influenza, Severe

Articles related to Influenza, Severe:

(show all 42)
# Title Authors PMID Year
1
IFITM3 restricts the morbidity and mortality associated with influenza. 6 57
22446628 2012
2
Interferon-induced cell membrane proteins, IFITM3 and tetherin, inhibit vesicular stomatitis virus infection via distinct mechanisms. 57 6
20943977 2010
3
Natural biflavonoids as potential therapeutic agents against microbial diseases. 61
33493916 2021
4
Ten Years of National Seasonal Surveillance for Severe Complications of Influenza in Australian Children. 61
33093432 2021
5
Exogenous pulmonary surfactant: A review focused on adjunctive therapy for severe acute respiratory syndrome coronavirus 2 including SP-A and SP-D as added clinical marker. 61
33390762 2021
6
Twenty-First Century Viral Pandemics: A Literature Review of Sexual Transmission and Fertility Implications in Men. 61
32713674 2020
7
SARS-CoV-2 infections and COVID-19 mortalities strongly correlate with ACE1 I/D genotype. 61
32628976 2020
8
Capturing respiratory syncytial virus season in Belgium using the influenza severe acute respiratory infection surveillance network, season 2018/19. 61
33006303 2020
9
Acute Mesenteric Ischemia in a Patient with COVID-19: A Case Report. 61
32979913 2020
10
Corticosteroid administration for viral pneumonia: COVID-19 and beyond. 61
32603802 2020
11
Political Intrusions into the International Health Regulations Treaty and Its Impact on Management of Rapidly Emerging Zoonotic Pandemics: What History Tells Us. 61
32279686 2020
12
Immune Predictors of Mortality After Ribonucleic Acid Virus Infection. 61
31621854 2020
13
Use of corticosteroids in influenza-associated acute respiratory distress syndrome and severe pneumonia: a systemic review and meta-analysis. 61
32080223 2020
14
Use of glucocorticoids in the critical care setting: Science and clinical evidence. 61
31626870 2020
15
Survival of the Enveloped Virus Phi6 in Droplets as a Function of Relative Humidity, Absolute Humidity, and Temperature. 61
29625986 2018
16
The rise of global health diplomacy: An interdisciplinary concept linking health and international relations. 61
28721965 2017
17
Discovery and Characterization of Diazenylaryl Sulfonic Acids as Inhibitors of Viral and Bacterial Neuraminidases. 61
28261167 2017
18
Antivirals for Respiratory Viral Infections: Problems and Prospects. 61
27486742 2016
19
Pandemic vaccination strategies and influenza severe outcomes during the influenza A(H1N1)pdm09 pandemic and the post-pandemic influenza season: the Nordic experience. 61
27123691 2016
20
Examining the policies and guidelines around the use of masks and respirators by healthcare workers in China, Pakistan and Vietnam. 61
28989404 2015
21
Severe complications in influenza-like illnesses. 61
25092942 2014
22
[Lessons learned from pandemic influenza severe cases since 2009]. 61
32288521 2014
23
Crimean-Congo Hemorrhagic Fever: Current Scenario in India. 61
32226205 2014
24
Innate immune function and mortality in critically ill children with influenza: a multicenter study. 61
23222256 2013
25
Disaster curricula in medical education: pilot survey. 61
22985793 2012
26
Risk assessment of airborne infectious diseases in aircraft cabins. 61
22313168 2012
27
First estimates of influenza vaccine effectiveness among severe influenza cases, France, 2011/12. 61
22587956 2012
28
European risk assessment guidance for infectious diseases transmitted on aircraft--the RAGIDA project. 61
21527131 2011
29
[Is H1N1 flu different from seasonal flu on initial plain chest films?]. 61
21458832 2011
30
[Characteristics of cases hospitalized for severe pandemic (H1N1) 2009 in Catalonia]. 61
21750846 2011
31
Review paper: the challenge of emerging zoonoses in Asia pacific. 61
20462853 2010
32
2009 H1N1 influenza: a twenty-first century pandemic with roots in the early twentieth century. 61
20697263 2010
33
Complications of seasonal and pandemic influenza. 61
19935413 2010
34
Prevention of influenza in mothers and infants. 61
19196194 2009
35
Sampling for global epidemic models and the topology of an international airport network. 61
18776932 2008
36
Respiratory hygiene in the emergency department. 61
17379028 2007
37
Respiratory hygiene in the emergency department. 61
17052558 2006
38
Emerging infectious disease issues in international adoptions: severe acute respiratory syndrome (SARS), avian influenza and measles. 61
15353957 2004
39
Factors and determinants of disease emergence. 61
15702712 2004
40
Influenza A and B virus infections in children. 61
12539071 2003
41
[Ultrastructural pathology of congenital infection provoked by respiratory viruses]. 61
1648904 1991
42
Mortality from pneumonia and risk conditions during influenza epidemics. High influenza morbidity during nonepidemic years. 61
577246 1977

Variations for Influenza, Severe

ClinVar genetic disease variations for Influenza, Severe:

6
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 IFITM3 NM_021034.3(IFITM3):c.42T>C (p.Ser14=) SNV risk factor 31527 rs12252 GRCh37: 11:320772-320772
GRCh38: 11:320772-320772

Expression for Influenza, Severe

Search GEO for disease gene expression data for Influenza, Severe.

Pathways for Influenza, Severe

GO Terms for Influenza, Severe

Sources for Influenza, Severe

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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