MCID: INF039
MIFTS: 42

Infratentorial Cancer

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Infratentorial Cancer

MalaCards integrated aliases for Infratentorial Cancer:

Name: Infratentorial Cancer 12 15 73
Infratentorial Neoplasms 44 73
Malignant Infratentorial Tumors 12
Brain Neoplasm, Infratentorial 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4706
ICD10 33 C71.7
MeSH 44 D015192
NCIt 50 C3139 C4966

Summaries for Infratentorial Cancer

Disease Ontology : 12 A brain cancer that is located in the infratentorial region.

MalaCards based summary : Infratentorial Cancer, also known as infratentorial neoplasms, is related to medulloblastoma and childhood infratentorial neoplasm. An important gene associated with Infratentorial Cancer is KMT2D (Lysine Methyltransferase 2D), and among its related pathways/superpathways are G-Beta Gamma Signaling and Signaling by Hedgehog. Affiliated tissues include brain, lung and bone, and related phenotypes are behavior/neurological and growth/size/body region

Related Diseases for Infratentorial Cancer

Diseases related to Infratentorial Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 86)
# Related Disease Score Top Affiliating Genes
1 medulloblastoma 29.9 ATOH1 CTNNB1 GLI1 GLI2 GLI3 KCTD11
2 childhood infratentorial neoplasm 12.2
3 vulva basal cell carcinoma 10.3 MYC PTCH1
4 holoprosencephaly, recurrent infections, and monocytosis 10.3 GLI2 PTCH1
5 pleuropulmonary blastoma 10.2 MYCN SHH TP53
6 septopreoptic holoprosencephaly 10.2 GLI2 PTCH1 SHH
7 midline interhemispheric variant of holoprosencephaly 10.2 GLI2 PTCH1 SHH
8 alobar holoprosencephaly 10.2 GLI2 PTCH1 SHH
9 lobar holoprosencephaly 10.2 GLI2 PTCH1 SHH
10 calcifying epithelial odontogenic tumor 10.2 GLI2 PTCH1 TP53
11 desmoplastic infantile ganglioglioma 10.2 MYCN SYP
12 semilobar holoprosencephaly 10.2 GLI2 PTCH1 SHH
13 holoprosencephaly 4 10.2 GLI3 MYC SHH
14 hypothyroidism, thyroidal or athyroidal, with spiky hair and cleft palate 10.2 GLI1 GLI2 SHH
15 bardet-biedl syndrome 17 10.2 GLI2 PTCH1 SHH
16 combined pituitary hormone deficiencies, genetic forms 10.2 GLI2 OTX2
17 leukocyte disease 10.2 KMT2D MYC TP53
18 physical disorder 10.2 GLI3 KMT2D SHH
19 autonomic nervous system neoplasm 10.2 MYC MYCN TP53
20 gastric squamous cell carcinoma 10.2 GLI1 SHH SYP
21 autosomal genetic disease 10.2 KMT2D PTCH1 TP53
22 agnathia-otocephaly complex 10.2 GLI2 OTX2 SHH
23 adult hepatocellular carcinoma 10.2 CTNNB1 TP53
24 gastric tubular adenocarcinoma 10.2 GLI1 SHH SYP
25 cerebral ventricle cancer 10.2 IER3IP1 SYP TP53
26 askin's tumor 10.2 MYC MYCN
27 cellular ependymoma 10.2 SYP TP53
28 microform holoprosencephaly 10.2 GLI2 PTCH1 SHH SUFU
29 central nervous system benign neoplasm 10.2 MYCN SYP TP53
30 holoprosencephaly 10.1 GLI2 GLI3 PTCH1 SHH
31 greig cephalopolysyndactyly syndrome 10.1 GLI2 GLI3 PTCH1 SHH
32 nasopharyngeal disease 10.1 CTNNB1 MYC TP53
33 pallister-hall syndrome 10.1 GLI1 GLI2 GLI3 SHH
34 pharynx cancer 10.1 CTNNB1 MYC TP53
35 cervix disease 10.1 CTNNB1 MYC TP53
36 lung acinar adenocarcinoma 10.1 CTNNB1 MYC
37 keratocystic odontogenic tumor 10.1 GLI1 PTCH1 SHH SUFU TP53
38 rhabdomyosarcoma 10.1 GLI1 MYCN PTCH1 TP53
39 merkel cell carcinoma 10.1 ATOH1 SYP TP53
40 esophageal atresia 10.1 GLI2 GLI3 MYCN SHH
41 male reproductive organ cancer 10.1 CTNNB1 MYC TP53
42 colonic disease 10.1 CTNNB1 MYC TP53
43 atypical follicular adenoma 10.1 SYP TP53
44 tanycytic ependymoma 10.1 KMT2D NES SYP
45 cerebellum cancer 10.1 ATOH1 SHH SYP TP53
46 tracheoesophageal fistula 10.1 GLI3 MYCN SHH SYP
47 cerebral primitive neuroectodermal tumor 10.1 MYC MYCN SYP TP53
48 central nervous system primitive neuroectodermal neoplasm 10.1 NES SYP TP53
49 respiratory system cancer 10.1 CTNNB1 MYC TP53
50 gastrointestinal system cancer 10.1 CTNNB1 KMT2D MYC TP53

Graphical network of the top 20 diseases related to Infratentorial Cancer:



Diseases related to Infratentorial Cancer

Symptoms & Phenotypes for Infratentorial Cancer

MGI Mouse Phenotypes related to Infratentorial Cancer:

46 (show all 25)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.44 ATOH1 CTNNB1 GLI1 GLI2 KMT2D MYC
2 growth/size/body region MP:0005378 10.42 CTNNB1 GLI1 GLI2 GLI3 KMT2D MYC
3 digestive/alimentary MP:0005381 10.41 ATOH1 CTNNB1 GLI1 GLI2 GLI3 MYC
4 cardiovascular system MP:0005385 10.4 CTNNB1 GLI3 KMT2D MYC MYCN NTRK3
5 mortality/aging MP:0010768 10.4 ATOH1 CTNNB1 GLI1 GLI2 GLI3 KMT2D
6 cellular MP:0005384 10.39 ATOH1 CTNNB1 GLI1 GLI2 GLI3 KMT2D
7 craniofacial MP:0005382 10.38 CTNNB1 GLI1 GLI2 GLI3 KMT2D MYC
8 embryo MP:0005380 10.37 CTNNB1 GLI1 GLI2 GLI3 KMT2D MYC
9 nervous system MP:0003631 10.35 ATOH1 CTNNB1 GLI1 GLI2 GLI3 KMT2D
10 homeostasis/metabolism MP:0005376 10.34 ATOH1 CTNNB1 GLI2 GLI3 KMT2D MYC
11 hearing/vestibular/ear MP:0005377 10.31 ATOH1 CTNNB1 GLI2 GLI3 KMT2D MYC
12 endocrine/exocrine gland MP:0005379 10.28 ATOH1 CTNNB1 GLI1 GLI2 GLI3 MYC
13 normal MP:0002873 10.28 ATOH1 CTNNB1 GLI1 GLI2 GLI3 MYC
14 limbs/digits/tail MP:0005371 10.24 CTNNB1 GLI1 GLI2 GLI3 MYC MYCN
15 no phenotypic analysis MP:0003012 10.23 ATOH1 CTNNB1 GLI1 GLI2 GLI3 MYC
16 muscle MP:0005369 10.21 CTNNB1 GLI2 KMT2D MYC MYCN OTX2
17 integument MP:0010771 10.2 ATOH1 CTNNB1 GLI2 GLI3 MYC PTCH1
18 neoplasm MP:0002006 10.1 CTNNB1 GLI1 KMT2D MYC PTCH1 SHH
19 respiratory system MP:0005388 10.07 ATOH1 CTNNB1 GLI1 GLI2 GLI3 KMT2D
20 reproductive system MP:0005389 10.06 CTNNB1 GLI1 GLI2 GLI3 MYC MYCN
21 renal/urinary system MP:0005367 9.97 CTNNB1 GLI1 GLI3 MYCN PPP1R12A PTCH1
22 pigmentation MP:0001186 9.95 CTNNB1 GLI3 MYC OTX2 PTCH1 SUFU
23 skeleton MP:0005390 9.9 CTNNB1 GLI2 GLI3 KMT2D MYC MYCN
24 taste/olfaction MP:0005394 9.35 CTNNB1 GLI3 OTX2 PTCH1 SHH
25 vision/eye MP:0005391 9.32 CTNNB1 GLI2 GLI3 MYCN NTRK3 OTX2

Drugs & Therapeutics for Infratentorial Cancer

Search Clinical Trials , NIH Clinical Center for Infratentorial Cancer

Cochrane evidence based reviews: infratentorial neoplasms

Genetic Tests for Infratentorial Cancer

Anatomical Context for Infratentorial Cancer

MalaCards organs/tissues related to Infratentorial Cancer:

41
Brain, Lung, Bone, Colon, Pancreas, Thyroid, Cerebellum

The Foundational Model of Anatomy Ontology organs/tissues related to Infratentorial Cancer:

19
The Infratentorial Region

Publications for Infratentorial Cancer

Articles related to Infratentorial Cancer:

# Title Authors Year
1
Infratentorial neoplasms, including the internal auditory canal and cerebellopontine angle regions. ( 2624770 )
1989

Variations for Infratentorial Cancer

Expression for Infratentorial Cancer

Search GEO for disease gene expression data for Infratentorial Cancer.

Pathways for Infratentorial Cancer

Pathways related to Infratentorial Cancer according to GeneCards Suite gene sharing:

(show all 22)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.9 CTNNB1 GLI1 GLI2 GLI3 PTCH1 SUFU
2
Show member pathways
12.45 GLI1 GLI2 GLI3 PTCH1 SHH SUFU
3 12.33 CTNNB1 GLI1 GLI2 GLI3 MYC PTCH1
4
Show member pathways
12.17 GLI1 GLI3 PPP1R12A PTCH1
5 12.1 CTNNB1 MYC PPP1R12A PTCH1 SHH TP53
6 12 CTNNB1 GLI3 MYC SHH
7 11.99 CTNNB1 GLI1 GLI2 PTCH1 SHH SUFU
8 11.95 MYC NES OTX2 SHH
9 11.86 CTNNB1 MED27 MYC TP53
10
Show member pathways
11.74 GLI1 GLI2 GLI3 PTCH1 SHH SUFU
11 11.68 NES SHH SYP
12 11.59 MYC MYCN TP53
13 11.56 MYC NTRK3 TP53
14
Show member pathways
11.4 CTNNB1 GLI1 GLI2 GLI3 PTCH1 SHH
15 11.3 GLI1 GLI2 PTCH1 SHH
16 11.2 CTNNB1 MYC TP53
17 11.15 GLI1 GLI2 OTX2 SHH
18
Show member pathways
11.13 GLI2 PTCH1 SHH
19
Show member pathways
10.98 MYC OTX2 TP53
20 10.55 GLI3 SHH
21 10.49 PTCH1 SHH
22 10.25 MYC MYCN

GO Terms for Infratentorial Cancer

Cellular components related to Infratentorial Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cilium GO:0005929 9.55 GLI1 GLI2 GLI3 PTCH1 SUFU
2 axoneme GO:0005930 9.43 GLI1 GLI2 GLI3
3 ciliary tip GO:0097542 9.26 GLI1 GLI2 GLI3 SUFU
4 ciliary base GO:0097546 8.92 GLI1 GLI2 GLI3 SUFU

Biological processes related to Infratentorial Cancer according to GeneCards Suite gene sharing:

(show top 50) (show all 86)
# Name GO ID Score Top Affiliating Genes
1 lung development GO:0030324 9.98 CTNNB1 GLI1 GLI2 GLI3 SHH
2 positive regulation of transcription, DNA-templated GO:0045893 9.96 CTNNB1 GLI1 GLI2 GLI3 MYC MYCN
3 forebrain development GO:0030900 9.95 CTNNB1 GLI3 OTX2 SHH
4 positive regulation of neuron differentiation GO:0045666 9.94 ATOH1 GLI2 KCTD11
5 pattern specification process GO:0007389 9.94 GLI2 GLI3 PTCH1 SHH
6 canonical Wnt signaling pathway GO:0060070 9.93 CTNNB1 GLI1 SHH
7 cellular response to drug GO:0035690 9.92 MYC PPP1R12A TP53
8 embryonic digit morphogenesis GO:0042733 9.92 CTNNB1 GLI2 GLI3 SHH
9 odontogenesis of dentin-containing tooth GO:0042475 9.92 CTNNB1 GLI2 GLI3 SHH
10 negative regulation of cell differentiation GO:0045596 9.91 CTNNB1 GLI3 SHH
11 embryonic limb morphogenesis GO:0030326 9.91 GLI3 PTCH1 SHH
12 inner ear development GO:0048839 9.91 ATOH1 GLI3 SHH
13 skin development GO:0043588 9.9 CTNNB1 SHH SUFU
14 limb development GO:0060173 9.9 CTNNB1 GLI3 SHH
15 midbrain development GO:0030901 9.9 CTNNB1 OTX2 SHH
16 mammary gland development GO:0030879 9.89 GLI2 GLI3 PTCH1
17 liver regeneration GO:0097421 9.89 GLI1 GLI3 MYC PTCH1
18 embryonic organ development GO:0048568 9.88 GLI3 PTCH1 SHH
19 smoothened signaling pathway GO:0007224 9.88 GLI1 GLI2 GLI3 PTCH1 SHH
20 T cell differentiation in thymus GO:0033077 9.87 CTNNB1 GLI3 SHH
21 beta-catenin-TCF complex assembly GO:1904837 9.87 CTNNB1 KMT2D MYC
22 developmental growth GO:0048589 9.87 GLI2 GLI3 SHH
23 branching morphogenesis of an epithelial tube GO:0048754 9.87 GLI2 GLI3 SHH
24 anatomical structure development GO:0048856 9.86 GLI2 GLI3 SHH
25 positive regulation of mesenchymal cell proliferation GO:0002053 9.86 CTNNB1 MYC SHH
26 anatomical structure formation involved in morphogenesis GO:0048646 9.85 GLI2 GLI3 SHH
27 renal system development GO:0072001 9.85 CTNNB1 PTCH1 SHH
28 positive regulation of neuroblast proliferation GO:0002052 9.85 CTNNB1 GLI3 SHH
29 negative regulation of smoothened signaling pathway GO:0045879 9.85 GLI3 KCTD11 PTCH1 SUFU
30 hindbrain development GO:0030902 9.84 CTNNB1 GLI2 SHH
31 proximal/distal pattern formation GO:0009954 9.84 CTNNB1 GLI1 GLI2 GLI3
32 regulation of smoothened signaling pathway GO:0008589 9.83 GLI1 GLI2 OTX2 PTCH1
33 dorsal/ventral neural tube patterning GO:0021904 9.81 GLI2 PTCH1 SHH
34 spinal cord motor neuron differentiation GO:0021522 9.8 GLI2 GLI3 PTCH1 SHH
35 smoothened signaling pathway involved in dorsal/ventral neural tube patterning GO:0060831 9.77 GLI2 GLI3 PTCH1
36 digestive tract morphogenesis GO:0048546 9.76 GLI1 SHH
37 ectoderm development GO:0007398 9.76 CTNNB1 SHH
38 regulation of osteoblast differentiation GO:0045667 9.76 CTNNB1 GLI1
39 layer formation in cerebral cortex GO:0021819 9.76 CTNNB1 GLI3
40 negative thymic T cell selection GO:0045060 9.75 GLI3 SHH
41 positive regulation of alpha-beta T cell differentiation GO:0046638 9.75 GLI3 SHH
42 positive regulation of T cell differentiation in thymus GO:0033089 9.75 GLI2 SHH
43 embryonic foregut morphogenesis GO:0048617 9.75 CTNNB1 SHH
44 positive regulation of production of miRNAs involved in gene silencing by miRNA GO:1903800 9.75 MYCN TP53
45 positive regulation of skeletal muscle tissue development GO:0048643 9.74 CTNNB1 SHH
46 artery development GO:0060840 9.74 GLI3 SHH
47 lung-associated mesenchyme development GO:0060484 9.74 CTNNB1 SHH
48 negative regulation of cell division GO:0051782 9.74 MYC PTCH1
49 hindgut morphogenesis GO:0007442 9.74 GLI2 GLI3 SHH
50 mammary gland duct morphogenesis GO:0060603 9.73 GLI2 PTCH1

Molecular functions related to Infratentorial Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 9.91 ATOH1 GLI1 GLI2 GLI3 KMT2D MYC
2 chromatin binding GO:0003682 9.77 CTNNB1 GLI1 GLI2 GLI3 TP53
3 transcription regulatory region DNA binding GO:0044212 9.76 GLI1 GLI2 KMT2D TP53
4 DNA-binding transcription factor activity GO:0003700 9.76 ATOH1 CTNNB1 GLI2 GLI3 MYC MYCN
5 transcription factor binding GO:0008134 9.72 CTNNB1 GLI2 MYC SUFU TP53
6 proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001077 9.43 ATOH1 GLI2 GLI3 MYC MYCN OTX2
7 patched binding GO:0005113 9.4 PTCH1 SHH
8 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.23 ATOH1 GLI1 GLI2 GLI3 MYC MYCN
9 DNA binding GO:0003677 10.09 ATOH1 GLI1 GLI2 GLI3 KMT2D MYC

Sources for Infratentorial Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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