MCID: INF039
MIFTS: 37

Infratentorial Cancer

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Infratentorial Cancer

MalaCards integrated aliases for Infratentorial Cancer:

Name: Infratentorial Cancer 12 15 73
Infratentorial Neoplasms 44 73
Malignant Infratentorial Tumors 12
Brain Neoplasm, Infratentorial 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4706
ICD10 33 C71.7
MeSH 44 D015192
NCIt 50 C3139 C4966

Summaries for Infratentorial Cancer

Disease Ontology : 12 A brain cancer that is located in the infratentorial region.

MalaCards based summary : Infratentorial Cancer, also known as infratentorial neoplasms, is related to medulloblastoma and childhood infratentorial neoplasm. An important gene associated with Infratentorial Cancer is SHH (Sonic Hedgehog), and among its related pathways/superpathways are G-Beta Gamma Signaling and Pathways in cancer. Affiliated tissues include the infratentorial region and brain, and related phenotypes are behavior/neurological and growth/size/body region

Related Diseases for Infratentorial Cancer

Diseases related to Infratentorial Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 76)
# Related Disease Score Top Affiliating Genes
1 medulloblastoma 25.6 ATOH1 CTNNB1 GLI1 GLI2 GLI3 KCTD11
2 childhood infratentorial neoplasm 12.1
3 vulva basal cell carcinoma 10.8 MYC PTCH1
4 holoprosencephaly, recurrent infections, and monocytosis 10.8 GLI2 PTCH1
5 septopreoptic holoprosencephaly 10.7 GLI2 PTCH1 SHH
6 midline interhemispheric variant of holoprosencephaly 10.7 GLI2 PTCH1 SHH
7 alobar holoprosencephaly 10.7 GLI2 PTCH1 SHH
8 combined pituitary hormone deficiencies, genetic forms 10.7 GLI2 OTX2
9 desmoplastic infantile ganglioglioma 10.7 MYCN SYP
10 lobar holoprosencephaly 10.7 GLI2 PTCH1 SHH
11 calcifying epithelial odontogenic tumor 10.7 GLI2 PTCH1 TP53
12 semilobar holoprosencephaly 10.7 GLI2 PTCH1 SHH
13 hypothyroidism, thyroidal or athyroidal, with spiky hair and cleft palate 10.7 GLI1 GLI2 SHH
14 holoprosencephaly 4 10.6 GLI3 MYC SHH
15 gastric squamous cell carcinoma 10.6 GLI1 SHH SYP
16 gastric tubular adenocarcinoma 10.6 GLI1 SHH SYP
17 cerebral ventricle cancer 10.6 IER3IP1 SYP TP53
18 cerebrum cancer 10.6 IER3IP1 SYP TP53
19 adult hepatocellular carcinoma 10.6 CTNNB1 TP53
20 agnathia-otocephaly complex 10.6 GLI2 OTX2 SHH
21 supratentorial cancer 10.6 IER3IP1 SYP TP53
22 tracheoesophageal fistula 10.6 GLI3 MYCN SHH
23 cellular ependymoma 10.5 SYP TP53
24 physical disorder 10.5 GLI3 IER3IP1 SHH
25 microform holoprosencephaly 10.5 GLI2 PTCH1 SHH SUFU
26 askin's tumor 10.5 MYC MYCN
27 lung acinar adenocarcinoma 10.4 CTNNB1 MYC
28 keratocystic odontogenic tumor 10.4 GLI1 PTCH1 SHH SUFU TP53
29 female reproductive endometrioid cancer 10.4 CTNNB1 TP53
30 pallister-hall syndrome 10.4 GLI1 GLI2 GLI3 SHH
31 merkel cell carcinoma 10.4 ATOH1 SYP TP53
32 rhabdomyosarcoma 10.4 GLI1 MYCN PTCH1 TP53
33 acinar cell carcinoma 10.4 CTNNB1 NTRK3 TP53
34 endocrine gland cancer 10.4 PTCH1 SYP TP53
35 central nervous system organ benign neoplasm 10.3 CTNNB1 SYP TP53
36 esophageal atresia 10.3 GLI2 GLI3 MYCN SHH
37 central nervous system primitive neuroectodermal neoplasm 10.3 NES SYP TP53
38 female reproductive organ cancer 10.3 CTNNB1 MYC TP53
39 pilomyxoid astrocytoma 10.3 SUFU SYP
40 cerebral primitive neuroectodermal tumor 10.3 MYC MYCN SYP TP53
41 peripheral nervous system neoplasm 10.3 MYC MYCN SYP TP53
42 meningioma, familial 10.3 PTCH1 SUFU SYP TP53
43 autonomic nervous system neoplasm 10.3 MYC MYCN SYP TP53
44 optic nerve neoplasm 10.3 NES SYP TP53
45 holoprosencephaly 10.3 GLI2 GLI3 PTCH1 SHH
46 organ system benign neoplasm 10.3 CTNNB1 SYP TP53
47 respiratory system cancer 10.3 CTNNB1 MYC TP53
48 optic nerve glioma 10.3 NES SYP TP53
49 atypical teratoid rhabdoid tumor 10.3 CTNNB1 SYP TP53
50 ganglioglioma 10.2 NES SYP TP53

Graphical network of the top 20 diseases related to Infratentorial Cancer:



Diseases related to Infratentorial Cancer

Symptoms & Phenotypes for Infratentorial Cancer

MGI Mouse Phenotypes related to Infratentorial Cancer:

46 (show all 24)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.43 GLI2 MYC OTX2 MYCN NTRK3 PROM1
2 growth/size/body region MP:0005378 10.41 GLI2 MYC GLI3 OTX2 MYCN PPP1R12A
3 digestive/alimentary MP:0005381 10.4 MYC GLI3 PPP1R12A OTX2 MYCN SHH
4 mortality/aging MP:0010768 10.4 GLI2 MYC GLI3 OTX2 MYCN PPP1R12A
5 cardiovascular system MP:0005385 10.39 MYC GLI3 OTX2 MYCN PPP1R12A NTRK3
6 cellular MP:0005384 10.38 GLI3 GLI2 MYC MYCN OTX2 PROM1
7 nervous system MP:0003631 10.35 GLI2 MYC GLI3 OTX2 MYCN NTRK3
8 craniofacial MP:0005382 10.34 MYC GLI3 GLI2 OTX2 MYCN SHH
9 embryo MP:0005380 10.32 GLI2 MYC GLI3 OTX2 MYCN SHH
10 normal MP:0002873 10.31 MYC GLI3 MYCN NTRK3 PROM1 OTX2
11 endocrine/exocrine gland MP:0005379 10.27 GLI3 GLI2 MYC OTX2 SHH PTCH1
12 no phenotypic analysis MP:0003012 10.27 MYC GLI3 NTRK3 PROM1 MYCN SHH
13 hearing/vestibular/ear MP:0005377 10.26 MYC GLI3 NTRK3 OTX2 SHH PTCH1
14 limbs/digits/tail MP:0005371 10.24 GLI2 MYC GLI3 MYCN SHH PTCH1
15 integument MP:0010771 10.2 GLI3 GLI2 MYC SHH PTCH1 TP53
16 muscle MP:0005369 10.16 GLI2 MYC MYCN OTX2 PPP1R12A SHH
17 neoplasm MP:0002006 10.1 MYC PROM1 SHH PTCH1 TP53 SUFU
18 respiratory system MP:0005388 10.03 GLI3 MYCN NTRK3 OTX2 SHH PTCH1
19 reproductive system MP:0005389 10.02 GLI2 MYC GLI3 MYCN OTX2 SHH
20 pigmentation MP:0001186 10.01 MYC GLI3 OTX2 PROM1 PTCH1 SUFU
21 renal/urinary system MP:0005367 9.97 GLI3 MYCN PPP1R12A SHH PTCH1 TP53
22 skeleton MP:0005390 9.85 GLI3 GLI2 MYC MYCN OTX2 SHH
23 vision/eye MP:0005391 9.36 GLI2 GLI3 OTX2 MYCN NTRK3 SHH
24 taste/olfaction MP:0005394 9.35 GLI3 OTX2 SHH PTCH1 CTNNB1

Drugs & Therapeutics for Infratentorial Cancer

Search Clinical Trials , NIH Clinical Center for Infratentorial Cancer

Cochrane evidence based reviews: infratentorial neoplasms

Genetic Tests for Infratentorial Cancer

Anatomical Context for Infratentorial Cancer

The Foundational Model of Anatomy Ontology organs/tissues related to Infratentorial Cancer:

19
The Infratentorial Region

MalaCards organs/tissues related to Infratentorial Cancer:

41
Brain

Publications for Infratentorial Cancer

Variations for Infratentorial Cancer

Expression for Infratentorial Cancer

Search GEO for disease gene expression data for Infratentorial Cancer.

Pathways for Infratentorial Cancer

Pathways related to Infratentorial Cancer according to GeneCards Suite gene sharing:

(show all 23)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.92 CTNNB1 GLI1 GLI2 GLI3 PTCH1 SUFU
2 12.53 CTNNB1 GLI1 GLI2 GLI3 MYC PTCH1
3
Show member pathways
12.47 GLI1 GLI2 GLI3 PTCH1 SHH SUFU
4
Show member pathways
12.19 GLI1 GLI3 PPP1R12A PTCH1
5 12.14 MYC MYCN PROM1 TP53
6 12.1 CTNNB1 MYC PPP1R12A PTCH1 SHH TP53
7 12.01 CTNNB1 GLI3 MYC SHH
8 11.95 MYC NES OTX2 PROM1 SHH
9 11.88 CTNNB1 MED27 MYC TP53
10
Show member pathways
11.84 GLI1 GLI2 GLI3 PTCH1 SHH SUFU
11 11.76 CTNNB1 GLI1 GLI2 PROM1 PTCH1 SHH
12 11.68 NES PROM1 SHH SYP
13 11.6 MYC MYCN TP53
14 11.58 MYC NTRK3 TP53
15
Show member pathways
11.4 CTNNB1 GLI1 GLI2 GLI3 PTCH1 SHH
16 11.3 GLI1 GLI2 PTCH1 SHH
17 11.23 CTNNB1 MYC TP53
18
Show member pathways
11.22 GLI2 PTCH1 SHH
19 11.15 GLI1 GLI2 OTX2 SHH
20
Show member pathways
11.01 MYC OTX2 TP53
21 10.57 GLI3 SHH
22 10.5 PTCH1 SHH
23 10.26 MYC MYCN

GO Terms for Infratentorial Cancer

Cellular components related to Infratentorial Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cilium GO:0005929 9.63 GLI1 GLI2 GLI3 PROM1 PTCH1 SUFU
2 axoneme GO:0005930 9.43 GLI1 GLI2 GLI3
3 ciliary tip GO:0097542 9.26 GLI1 GLI2 GLI3 SUFU
4 ciliary base GO:0097546 8.92 GLI1 GLI2 GLI3 SUFU

Biological processes related to Infratentorial Cancer according to GeneCards Suite gene sharing:

(show top 50) (show all 89)
# Name GO ID Score Top Affiliating Genes
1 canonical Wnt signaling pathway GO:0060070 9.97 CTNNB1 GLI1 MYC SHH
2 forebrain development GO:0030900 9.96 CTNNB1 GLI3 OTX2 SHH
3 positive regulation of transcription, DNA-templated GO:0045893 9.96 CTNNB1 GLI1 GLI2 GLI3 MYC MYCN
4 anterior/posterior pattern specification GO:0009952 9.94 GLI2 GLI3 SHH
5 response to estradiol GO:0032355 9.94 CTNNB1 MYC PTCH1
6 odontogenesis of dentin-containing tooth GO:0042475 9.94 CTNNB1 GLI2 GLI3 SHH
7 positive regulation of neuron differentiation GO:0045666 9.93 ATOH1 GLI2 KCTD11
8 pattern specification process GO:0007389 9.93 GLI2 GLI3 PTCH1 SHH
9 negative regulation of cell death GO:0060548 9.92 CTNNB1 MYC NTRK3
10 negative regulation of cell differentiation GO:0045596 9.92 CTNNB1 GLI3 SHH
11 cellular response to drug GO:0035690 9.92 MYC PPP1R12A TP53
12 smoothened signaling pathway GO:0007224 9.92 GLI1 GLI2 GLI3 PTCH1 SHH
13 embryonic limb morphogenesis GO:0030326 9.91 GLI3 PTCH1 SHH
14 inner ear development GO:0048839 9.91 ATOH1 GLI3 SHH
15 liver regeneration GO:0097421 9.91 GLI1 GLI3 MYC PTCH1
16 skin development GO:0043588 9.9 CTNNB1 SHH SUFU
17 limb development GO:0060173 9.9 CTNNB1 GLI3 SHH
18 embryonic organ development GO:0048568 9.9 GLI3 PTCH1 SHH
19 midbrain development GO:0030901 9.89 CTNNB1 OTX2 SHH
20 mammary gland development GO:0030879 9.89 GLI2 GLI3 PTCH1
21 branching morphogenesis of an epithelial tube GO:0048754 9.89 GLI2 GLI3 MYCN SHH
22 anatomical structure development GO:0048856 9.88 GLI2 GLI3 SHH
23 positive regulation of mesenchymal cell proliferation GO:0002053 9.88 CTNNB1 MYC MYCN SHH
24 T cell differentiation in thymus GO:0033077 9.87 CTNNB1 GLI3 SHH
25 developmental growth GO:0048589 9.87 GLI2 GLI3 SHH
26 anatomical structure formation involved in morphogenesis GO:0048646 9.86 GLI2 GLI3 SHH
27 negative regulation of smoothened signaling pathway GO:0045879 9.86 GLI3 KCTD11 PTCH1 SUFU
28 renal system development GO:0072001 9.85 CTNNB1 PTCH1 SHH
29 hindbrain development GO:0030902 9.85 CTNNB1 GLI2 SHH
30 positive regulation of neuroblast proliferation GO:0002052 9.85 CTNNB1 GLI3 SHH
31 proximal/distal pattern formation GO:0009954 9.85 CTNNB1 GLI1 GLI2 GLI3
32 regulation of smoothened signaling pathway GO:0008589 9.84 GLI1 GLI2 OTX2 PTCH1
33 dorsal/ventral neural tube patterning GO:0021904 9.83 GLI2 PTCH1 SHH
34 embryonic digit morphogenesis GO:0042733 9.83 CTNNB1 GLI2 GLI3 MYCN SHH
35 branching involved in ureteric bud morphogenesis GO:0001658 9.8 CTNNB1 GLI3 MYC PTCH1 SHH
36 lung development GO:0030324 9.8 CTNNB1 GLI1 GLI2 GLI3 MYCN SHH
37 smoothened signaling pathway involved in dorsal/ventral neural tube patterning GO:0060831 9.79 GLI2 GLI3 PTCH1
38 regulation of osteoblast differentiation GO:0045667 9.76 CTNNB1 GLI1
39 digestive tract morphogenesis GO:0048546 9.76 GLI1 SHH
40 ectoderm development GO:0007398 9.76 CTNNB1 SHH
41 layer formation in cerebral cortex GO:0021819 9.76 CTNNB1 GLI3
42 spinal cord motor neuron differentiation GO:0021522 9.76 GLI2 GLI3 PTCH1 SHH
43 negative thymic T cell selection GO:0045060 9.75 GLI3 SHH
44 positive regulation of alpha-beta T cell differentiation GO:0046638 9.75 GLI3 SHH
45 positive regulation of T cell differentiation in thymus GO:0033089 9.75 GLI2 SHH
46 negative regulation of astrocyte differentiation GO:0048712 9.75 MYCN NTRK3
47 positive regulation of skeletal muscle tissue development GO:0048643 9.75 CTNNB1 SHH
48 hindgut morphogenesis GO:0007442 9.75 GLI2 GLI3 SHH
49 embryonic foregut morphogenesis GO:0048617 9.74 CTNNB1 SHH
50 artery development GO:0060840 9.74 GLI3 SHH

Molecular functions related to Infratentorial Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0000981 9.97 ATOH1 GLI1 GLI2 GLI3 MYC MYCN
2 chromatin binding GO:0003682 9.83 CTNNB1 GLI1 GLI2 GLI3 TP53
3 DNA binding transcription factor activity GO:0003700 9.76 ATOH1 CTNNB1 GLI2 GLI3 MYC MYCN
4 transcription factor binding GO:0008134 9.72 CTNNB1 GLI2 MYC SUFU TP53
5 cholesterol binding GO:0015485 9.43 PROM1 PTCH1 SYP
6 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding GO:0001077 9.43 ATOH1 GLI2 GLI3 MYC MYCN OTX2
7 patched binding GO:0005113 9.4 PTCH1 SHH
8 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.23 ATOH1 GLI1 GLI2 GLI3 MYC MYCN

Sources for Infratentorial Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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