MCID: INF039
MIFTS: 38

Infratentorial Cancer

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Infratentorial Cancer

MalaCards integrated aliases for Infratentorial Cancer:

Name: Infratentorial Cancer 12 15 70
Infratentorial Neoplasms 44 70
Malignant Infratentorial Tumors 12
Brain Neoplasm, Infratentorial 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4706
MeSH 44 D015192
NCIt 50 C3139 C4966
ICD10 32 C71.7
UMLS 70 C0021432 C0751593

Summaries for Infratentorial Cancer

Disease Ontology : 12 A brain cancer that is located in the infratentorial region.

MalaCards based summary : Infratentorial Cancer, also known as infratentorial neoplasms, is related to medulloblastoma and ovary leiomyosarcoma. An important gene associated with Infratentorial Cancer is KDM4C (Lysine Demethylase 4C), and among its related pathways/superpathways are Pathways in cancer and Signaling by Hedgehog. The drugs Fentanyl and Bupivacaine have been mentioned in the context of this disorder. Affiliated tissues include infratentorial region, brain and eye, and related phenotypes are craniofacial and digestive/alimentary

Related Diseases for Infratentorial Cancer

Diseases related to Infratentorial Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 218)
# Related Disease Score Top Affiliating Genes
1 medulloblastoma 31.6 TP53 SUFU SHH PTCH1 MYCN MYC
2 ovary leiomyosarcoma 10.5 SUFU PTCH1
3 holoprosencephaly, recurrent infections, and monocytosis 10.5 PTCH1 GLI2
4 cerebellar medulloblastoma 10.5 SHH PTCH1 GLI1
5 midline interhemispheric variant of holoprosencephaly 10.5 SHH PTCH1 GLI2
6 septopreoptic holoprosencephaly 10.5 SHH PTCH1 GLI2
7 holoprosencephaly 9 10.5 SHH PTCH1 GLI2
8 fetal alcohol spectrum disorder 10.5 SHH MIR9-1 KDM4C H2AC18
9 fetal alcohol syndrome 10.5 SHH MIR9-1 KDM4C H2AC18
10 alobar holoprosencephaly 10.5 SHH PTCH1 GLI2
11 lobar holoprosencephaly 10.5 SHH PTCH1 GLI2
12 calcifying epithelial odontogenic tumor 10.5 TP53 PTCH1 GLI2
13 holoprosencephaly 11 10.5 SHH PTCH1 GLI2
14 holoprosencephaly 5 10.5 SHH PTCH1 GLI2
15 chromosomal duplication syndrome 10.5 SHH MIR9-1 KDM4C H2AC18
16 holoprosencephaly 7 10.5 SHH PTCH1 GLI2
17 solitary median maxillary central incisor 10.5 SHH PTCH1 GLI2
18 semilobar holoprosencephaly 10.5 SHH PTCH1 GLI2
19 focal dermal hypoplasia 10.5 SUFU SHH PTCH1
20 central nervous system primitive neuroectodermal neoplasm 10.5 TP53 SHH MYCN
21 large cell medulloblastoma 10.5 SUFU SHH MYC
22 anal carcinoma in situ 10.5 TP53 MYC
23 melanotic medulloblastoma 10.5 SUFU SHH PTCH1 GLI2
24 diffuse astrocytoma 10.5 TP53 KDM4C H2AC18
25 anus, imperforate 10.5 SHH GLI2 GLI1
26 greig cephalopolysyndactyly syndrome 10.5 SHH PTCH1 GLI2 GLI1
27 pallister-hall syndrome 10.5 SHH PTCH1 GLI2 GLI1
28 microform holoprosencephaly 10.5 SUFU SHH PTCH1 GLI2
29 connective tissue benign neoplasm 10.5 TP53 PTCH1 H2AC18
30 cardiovascular organ benign neoplasm 10.5 TP53 KDM4C H2AC18 APC
31 oropharynx cancer 10.5 TP53 MIR9-1 H2AC18 APC
32 brachydactyly, type a1 10.5 SHH PTCH1 GLI1
33 frontal lobe neoplasm 10.5 TP53 MYCN MYC
34 chromosomal deletion syndrome 10.5 MIR9-1 MIR19A MIR17 KDM4C H2AC18
35 central nervous system hematologic cancer 10.5 MYC MIR18A KDM4C
36 inherited metabolic disorder 10.5 MIR9-1 MIR17 KDM4C H2AC18
37 blood protein disease 10.5 MYC MIR19A MIR17 H2AC18
38 chromosomal disease 10.5 SHH MIR9-1 MIR17 KDM4C H2AC18
39 nut midline carcinoma 10.5 MYC KDM4C H2AC18
40 tumoral calcinosis, hyperphosphatemic, familial, 1 10.5 SHH PTCH1 GLI1
41 central nervous system benign neoplasm 10.5 TP53 MYCN KDM4C H2AC18
42 hemimelia 10.5 GLI2 GLI1
43 supratentorial primitive neuroectodermal tumor 10.5 SHH MYCN MYC APC
44 respiratory system benign neoplasm 10.5 TP53 MYC H2AC18
45 diffuse midline glioma, h3 k27m-mutant 10.5 TP53 MYCN H2AC18
46 chromosome 16p13.3 deletion syndrome, proximal 10.5 MIR9-1 KDM4C H2AC18
47 congenital nervous system abnormality 10.5 SHH PTCH1 MIR9-1 H2AC18 GLI2
48 germ cell cancer 10.5 MYC MIR9-1 KDM4C H2AC18
49 pleuropulmonary blastoma 10.5 TP53 SHH MYCN
50 cerebellar disease 10.5 TP53 MIR9-1 KDM4C H2AC18

Graphical network of the top 20 diseases related to Infratentorial Cancer:



Diseases related to Infratentorial Cancer

Symptoms & Phenotypes for Infratentorial Cancer

MGI Mouse Phenotypes related to Infratentorial Cancer:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 10.06 APC GLI1 GLI2 MYC MYCN PTCH1
2 digestive/alimentary MP:0005381 10.02 APC GLI1 GLI2 MYC MYCN PTCH1
3 embryo MP:0005380 9.97 APC GLI1 GLI2 MYC MYCN PTCH1
4 limbs/digits/tail MP:0005371 9.91 APC GLI1 GLI2 MYC MYCN PTCH1
5 neoplasm MP:0002006 9.76 APC GLI1 KDM4C MYC PTCH1 SHH
6 no phenotypic analysis MP:0003012 9.61 GLI1 GLI2 KDM4C MYC MYCN PTCH1
7 normal MP:0002873 9.28 APC GLI1 GLI2 MYC MYCN PTCH1

Drugs & Therapeutics for Infratentorial Cancer

Drugs for Infratentorial Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
2
Bupivacaine Approved, Investigational Phase 3 2180-92-9, 38396-39-3 2474
3
Morphine Approved, Investigational Phase 2 57-27-2 5288826
4 Anesthetics Phase 2
5 Narcotics Phase 2
6 Analgesics, Opioid Phase 2
7 Anesthetics, Local Phase 2

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Ultrasound-guided Greater Occipital Nerve Block in Children Undergoing Posterior Fossa Craniotomy: Randomized, Controlled Study Completed NCT03762343 Phase 3 ultrasound guided Greater occipital nerve block;control group C
2 The Effects of Scalp Block on Haemodynamic Response and Postoperative Pain in Completed NCT02852382 Phase 2 Bupivacaine;morphine patient controlled analgesia
3 Efficacy of Intravenous Acetaminophen as Analgesic Adjuvant Therapy in Children Undergoing Posterior Fossa Surgery Withdrawn NCT02532322 Phase 2 IV acetaminophen;normal saline
4 Effects of the Prone and the Sitting Positions on the Brain Oxygenation in Posterior Fossa Surgery Unknown status NCT02933749
5 The Effect of Cognitive and Motor Training on Executive Functions, Motor Skills, and Saccadic Eye Movements System in Pediatric Posterior Fossa Tumor Survivors Completed NCT03951246
6 Nordic Study of the Cerebellar Mutism Syndrome in Children With Brain Tumours of the Posterior Fossa Recruiting NCT02300766
7 The Effect of Different Ventilation Strategies on Cerebral Oxygenation Using Near Infrared Spectroscopy (NIRS) in Pediatrics Undergoing Posterior Fossa Tumor Surgery: Randomized Controlled Cross Over Study Recruiting NCT04232059
8 The ASsessment and Physiotherapy managEment of Ataxia in Children Following Surgical Resection of Posterior Fossa Tumour (ASPECT) Recruiting NCT03945682
9 Impact of Physical Activity on Postural Stability and Coordination in Children With Posterior Fossa Tumor Recruiting NCT04528316
10 Child's Study of the Distant Impact of Posterior Fossa Injury on Motor Skills, Language, Cognitive Functioning, and Social Cognition - a Combination of Clinical Assessments and Brain Imaging Recruiting NCT04174820
11 Advanced MRI in Surgery for Posterior Fossa Tumours - Predicting Post-operative Paediatric Cerebellar Mutism Syndrome and Surgical Guidance to Avoid it Active, not recruiting NCT03471026

Search NIH Clinical Center for Infratentorial Cancer

Cochrane evidence based reviews: infratentorial neoplasms

Genetic Tests for Infratentorial Cancer

Anatomical Context for Infratentorial Cancer

The Foundational Model of Anatomy Ontology organs/tissues related to Infratentorial Cancer:

19
Infratentorial Region

MalaCards organs/tissues related to Infratentorial Cancer:

40
Brain, Eye

Publications for Infratentorial Cancer

Articles related to Infratentorial Cancer:

# Title Authors PMID Year
1
Tumor-related hydrocephalus in infants: a narrative review. 61
33768312 2021
2
Chromosome arm 17p deletion analysis reveals molecular genetic heterogeneity in supratentorial and infratentorial primitive neuroectodermal tumors of the central nervous system. 61
9242214 1997
3
Infratentorial neoplasms, including the internal auditory canal and cerebellopontine angle regions. 61
2624770 1989

Variations for Infratentorial Cancer

Expression for Infratentorial Cancer

Search GEO for disease gene expression data for Infratentorial Cancer.

Pathways for Infratentorial Cancer

Pathways related to Infratentorial Cancer according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1 12.7 TP53 SUFU SHH PTCH1 MYC GLI2
2
Show member pathways
12.48 SUFU SHH PTCH1 GLI2 GLI1
3
Show member pathways
12.3 TP53 MYC MIR20A MIR19A MIR18A MIR17
4 12.18 TP53 SHH PTCH1 MYC
5 12.14 SUFU SHH PTCH1 GLI2 GLI1 APC
6
Show member pathways
12.02 TP53 SUFU SHH PTCH1 GLI2 GLI1
7 11.85 TP53 MYC MIR9-1 MIR34C MIR324 MIR25
8 11.76 MIR34C MIR20A MIR19A MIR18A MIR17
9 11.57 TP53 MYCN MYC
10 11.49 TP53 MYC MIR34C MIR25
11 11.47 SUFU SHH PTCH1 GLI2 GLI1
12 11.37 SHH PTCH1 GLI2 GLI1
13 11.3 SUFU SHH PTCH1 GLI2 GLI1
14
Show member pathways
11.23 SHH PTCH1 GLI2
15 11.18 SHH GLI2 GLI1
16 11.13 TP53 MYC MIR34C
17
Show member pathways
10.63 SUFU SHH PTCH1 GLI2 GLI1
18 10.49 SHH PTCH1
19 10.26 MYCN MYC

GO Terms for Infratentorial Cancer

Cellular components related to Infratentorial Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ciliary tip GO:0097542 9.13 SUFU GLI2 GLI1
2 ciliary base GO:0097546 8.8 SUFU GLI2 GLI1

Biological processes related to Infratentorial Cancer according to GeneCards Suite gene sharing:

(show all 38)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription by RNA polymerase II GO:0000122 10.14 TP53 SUFU SHH PTCH1 MYC GLI2
2 positive regulation of cell proliferation GO:0008284 10.07 SHH MYC KDM4C GLI2 GLI1
3 positive regulation of transcription, DNA-templated GO:0045893 10.07 TP53 SHH PTCH1 MYCN MYC GLI2
4 negative regulation of apoptotic process GO:0043066 10.06 TP53 SHH MYC MIR19A GLI2
5 positive regulation of gene expression GO:0010628 10.05 TP53 SHH MYCN MYC KDM4C
6 negative regulation of gene expression GO:0010629 9.97 TP53 SHH MYCN MIR20A MIR17
7 gene silencing by miRNA GO:0035195 9.86 MIR9-1 MIR34C MIR25 MIR219A1 MIR20A MIR19A
8 lung development GO:0030324 9.85 SHH GLI2 GLI1
9 negative regulation of osteoblast differentiation GO:0045668 9.79 SUFU PTCH1 MIR9-1
10 embryonic organ development GO:0048568 9.77 TP53 SHH PTCH1
11 branching involved in ureteric bud morphogenesis GO:0001658 9.76 SHH PTCH1 MYC
12 pattern specification process GO:0007389 9.76 SHH PTCH1 GLI2 APC
13 negative regulation of smoothened signaling pathway GO:0045879 9.72 SUFU PTCH1 GLI2
14 dorsal/ventral pattern formation GO:0009953 9.71 SHH PTCH1 GLI2 GLI1
15 spinal cord motor neuron differentiation GO:0021522 9.69 SHH PTCH1 GLI2
16 digestive tract morphogenesis GO:0048546 9.68 SHH GLI1
17 prostate gland development GO:0030850 9.67 SHH PTCH1 GLI1
18 positive regulation of production of miRNAs involved in gene silencing by miRNA GO:1903800 9.66 TP53 MYCN
19 smooth muscle tissue development GO:0048745 9.65 SHH PTCH1
20 metanephric collecting duct development GO:0072205 9.65 SHH PTCH1
21 dorsal/ventral neural tube patterning GO:0021904 9.65 SHH PTCH1 GLI2
22 positive regulation of T cell differentiation in thymus GO:0033089 9.64 SHH GLI2
23 negative regulation of cell division GO:0051782 9.64 PTCH1 MYC
24 positive regulation of B cell receptor signaling pathway GO:0050861 9.63 MIR19A MIR18A
25 smoothened signaling pathway involved in dorsal/ventral neural tube patterning GO:0060831 9.63 PTCH1 GLI2
26 mammary gland duct morphogenesis GO:0060603 9.62 PTCH1 GLI2
27 positive regulation of pulmonary blood vessel remodeling GO:1905111 9.61 MIR20A MIR17
28 cerebellar cortex morphogenesis GO:0021696 9.61 GLI2 GLI1
29 positive regulation of cardiac muscle hypertrophy in response to stress GO:1903244 9.61 MIR34C MIR20A MIR17
30 hindgut morphogenesis GO:0007442 9.6 SHH GLI2
31 smoothened signaling pathway involved in spinal cord motor neuron cell fate specification GO:0021776 9.57 SUFU GLI2
32 smoothened signaling pathway involved in ventral spinal cord interneuron specification GO:0021775 9.56 SUFU GLI2
33 smoothened signaling pathway GO:0007224 9.55 SUFU SHH PTCH1 GLI2 GLI1
34 notochord regression GO:0060032 9.54 GLI2 GLI1
35 smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation GO:0021938 9.54 SHH GLI2 GLI1
36 spinal cord dorsal/ventral patterning GO:0021513 9.5 SUFU SHH GLI2
37 ventral midline development GO:0007418 9.13 SHH GLI2 GLI1
38 negative regulation of sprouting angiogenesis GO:1903671 9.02 MIR34C MIR20A MIR19A MIR18A MIR17

Molecular functions related to Infratentorial Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA 3'-UTR binding GO:0003730 9.26 TP53 MIR9-1 MIR20A MIR17
2 mRNA binding involved in posttranscriptional gene silencing GO:1903231 9.17 MIR9-1 MIR25 MIR219A1 MIR20A MIR19A MIR18A
3 patched binding GO:0005113 9.16 SHH PTCH1

Sources for Infratentorial Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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