Infratentorial Cancer disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MalaCards based summary: Infratentorial Cancer, also known as infratentorial neoplasms, is related to medulloblastoma and blastoma. An important gene associated with Infratentorial Cancer is KDM4C (Lysine Demethylase 4C), and among its related pathways/superpathways are Signal Transduction and Signaling by Hedgehog. The drugs Bupivacaine and Fentanyl have been mentioned in the context of this disorder. Affiliated tissues include infratentorial region, brain and eye, and related phenotypes are normal and neoplasm

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Related Diseases for Infratentorial Cancer

Diseases related to Infratentorial Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 355)

#	Related Disease	Score	Top Affiliating Genes
1	medulloblastoma	31.9	TP53 SUFU SHH PTCH1 MYCN MYC
2	blastoma	10.5	TP53 SHH MYCN
3	holoprosencephaly, recurrent infections, and monocytosis	10.5	PTCH1 GLI2
4	acrocapitofemoral dysplasia	10.5	SHH PTCH1 GLI1
5	fetal alcohol syndrome	10.5	SHH MIR9-1 KDM4C H2AC18
6	holoprosencephaly 11	10.5	SHH PTCH1 GLI2
7	midline interhemispheric variant of holoprosencephaly	10.5	SHH PTCH1 GLI2
8	septopreoptic holoprosencephaly	10.5	SHH PTCH1 GLI2
9	fetal alcohol spectrum disorder	10.5	SHH MIR9-1 KDM4C H2AC18
10	vulva basal cell carcinoma	10.5	SHH PTCH1 MYC
11	basosquamous carcinoma	10.5	TP53 PTCH1 GLI1
12	alobar holoprosencephaly	10.5	SHH PTCH1 GLI2
13	lobar holoprosencephaly	10.5	SHH PTCH1 GLI2
14	medullomyoblastoma	10.5	SUFU SHH MYC
15	holoprosencephaly 3	10.5	SHH PTCH1 GLI2
16	primary ovarian insufficiency 6	10.5	SUFU SHH
17	semilobar holoprosencephaly	10.5	SHH PTCH1 GLI2
18	diffuse astrocytoma	10.5	TP53 KDM4C H2AC18
19	solitary median maxillary central incisor	10.5	SHH PTCH1 GLI2
20	holoprosencephaly	10.5	SHH PTCH1 GLI2 GLI1
21	vacterl association	10.5	SHH GLI2 GLI1
22	central nervous system primitive neuroectodermal neoplasm	10.5	TP53 SHH MYCN
23	microform holoprosencephaly	10.5	SUFU SHH PTCH1 GLI2
24	glioma	10.5	TP53 MIR25 MIR17 GLI1
25	joubert syndrome 8	10.5	SUFU SHH PTCH1 GLI2
26	primary mediastinal b-cell lymphoma	10.5	MYC MIR9-1 MIR155 KDM4C
27	brachydactyly, type a1	10.5	SHH PTCH1 GLI1
28	chromosomal deletion syndrome	10.5	MIR9-1 MIR17 KDM4C H2AC18
29	penis carcinoma in situ	10.5	TP53 SUFU PTCH1 GLI1
30	pineoblastoma	10.5	TP53 SHH MYCN
31	central nervous system hematologic cancer	10.5	MYC MIR9-1 KDM4C
32	serous cystadenocarcinoma	10.5	TP53 MIR199A1 H2AC18
33	micronodular basal cell carcinoma	10.5	TP53 SHH PTCH1 GLI2
34	anus, imperforate	10.5	SHH GLI2 GLI1
35	frontal lobe neoplasm	10.5	TP53 MYCN MYC
36	histone mutated tumor	10.5	TP53 MYCN H2AC18
37	cerebral ventricle cancer	10.5	TP53 SHH MYCN
38	diffuse midline glioma, h3 k27m-mutant	10.5	TP53 MYCN H2AC18
39	supratentorial cancer	10.5	TP53 SHH MYCN H2AC18
40	pallister-hall syndrome	10.5	SHH PTCH1 GLI2 GLI1
41	primary cutaneous t-cell non-hodgkin lymphoma	10.5	MIR17 MIR155 KDM4C H2AC18
42	anus disease	10.5	TP53 SHH H2AC18
43	nut midline carcinoma	10.5	MYC KDM4C H2AC18
44	rhabdoid cancer	10.5	TP53 SHH MIR9-1 KDM4C H2AC18
45	acrocallosal syndrome	10.5	SUFU SHH GLI1
46	cerebrum cancer	10.5	TP53 SHH MYCN
47	estrogen-receptor negative breast cancer	10.5	TP53 MYC H2AC18
48	polydactyly, preaxial ii	10.5	SHH PTCH1
49	lung adenoma	10.5	TP53 MYC H2AC18
50	connective tissue benign neoplasm	10.5	TP53 PTCH1 H2AC18

Graphical network of the top 20 diseases related to Infratentorial Cancer:

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Symptoms & Phenotypes for Infratentorial Cancer

MGI Mouse Phenotypes related to Infratentorial Cancer:

⁴⁵ (show all 11)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	normal	MP:0002873	10.2	APC GLI1 GLI2 MIR155 MIR182 MYC
2	neoplasm	MP:0002006	10.18	APC GLI1 KDM4C MIR182 MYC PTCH1
3	no phenotypic analysis	MP:0003012	10.17	GLI1 GLI2 KDM4C MIR199A1 MIR9-1 MYC
4	limbs/digits/tail	MP:0005371	10.06	APC GLI1 GLI2 MYC MYCN PTCH1
5	pigmentation	MP:0001186	9.97	APC MYC PTCH1 SUFU TP53 U2AF1
6	embryo	MP:0005380	9.97	APC GLI1 GLI2 MYC MYCN PTCH1
7	digestive/alimentary	MP:0005381	9.96	APC GLI1 GLI2 MIR155 MYC MYCN
8	hearing/vestibular/ear	MP:0005377	9.91	APC GLI2 MYC PTCH1 SHH TP53
9	craniofacial	MP:0005382	9.81	APC GLI1 GLI2 MYC MYCN PTCH1
10	respiratory system	MP:0005388	9.56	GLI1 GLI2 MIR155 MYCN PTCH1 SHH
11	integument	MP:0010771	9.28	APC GLI2 KDM4C MYC PTCH1 SHH

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Drugs & Therapeutics for Infratentorial Cancer

Drugs for Infratentorial Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Bupivacaine

Approved, Investigational

Phase 3

2180-92-9, 38396-39-3

2474

2

Fentanyl

Approved, Illicit, Investigational, Vet_approved

Phase 3

437-38-7

3345

3

Morphine

Approved, Investigational

Phase 2

57-27-2

5288826

4

Anesthetics, Local

Phase 2

5

Anesthetics

Phase 2

6

Analgesics, Opioid

Phase 2

7

Narcotics

Phase 2

8

Racepinephrine

Approved, Vet_approved

Phase 1

51-43-4, 329-65-7

838 5816

Synonyms:

(−)-(R)-epinephrine

(-)-(R)-Epinephrine

(-)-3,4-Dihydroxy-a-((methylamino)methyl)benzyl alcohol

(-)-3,4-Dihydroxy-a-[(methylamino)methyl]-benzyl alcohol

(-)-3,4-Dihydroxy-a-[2-(methylamino)ethyl]benzyl alcohol

(-)-3,4-Dihydroxy-alpha-((methylamino)methyl)benzyl alcohol

(-)-3,4-Dihydroxy-alpha-[(methylamino)methyl]-benzyl alcohol

(-)-3,4-DIHYDROXY-ALPHA-[(METHYLAMINO)METHYL]BENZYL ALCOHOL(-)-3,4-DIHYDROXY-ALPHA-[(METHYLAMINO)METHYL]-BENZYL ALCOHOL

(-)-3,4-Dihydroxy-alpha-[2-(methylamino)ethyl]benzyl alcohol

(−)-3,4-dihydroxy-α-((methylamino)methyl)benzyl alcohol

(-)-3,4-Dihydroxy-α-((methylamino)methyl)benzyl alcohol

(-)-Adrenaline

(−)-ADRENALINE

(-)-Epinephrine

(+-)-Adrenaline

(+-)-Epinephrine

(R)-(-)-Adnephrine

(R)-(-)-Adrenaline

(R)-(−)-ADRENALINE

(R)-(-)-Epinephrine

(R)-(-)-Epirenamine

(R)-4-[1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol

(R)-Adrenaline

(R)-Epinephrine

2-(Methylamino)-1-(3,4-dihydroxyphenyl)ethanol

4-(1-Hydroxy-2-(methylamino)ethyl)-1,2-benzenediol

4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol

4-[(1R)-1-HYDROXY-2-METHYLAMINOETHYL]BENZENE-1,2-DIOL

4-[(1R)-1-HYDROXY-2-METHYLAMINO-ETHYL]BENZENE-1,2-DIOL

4-[(1R)-1-HYDROXY-2-METHYLAMINO-ETHYL]PYROCATECHOL

Acetate, epinephrine

Adnephrine

ADREN CO

ADRENACLICK

Adrenal

Adrenalin

Adrenaline

Adrénaline

Adrenaline acid tartrate

Adrenaline bitartrate

Adrenaline hydrochloride

Adrenaline hydrochloride, racemic mixture

Adrenaline, racemic

Adrenaline, racemic mixture

adrenaline|epinephrine

Adrenine

Adrin

Allergan brand OF adrenaline hydrochloride

ANA-GUARD

Ana-kit

ANAPEN

ANAPHYLACTIC SHOCK DRUG KIT

ASMA-VYDRIN

ASTHMAHALER

Auvi-Q

Bird brand OF racepinefrine hydrochloride

Bosmin

Bronkaid mist

BROVON

Chelafrin

DL-Adrenaline

EMERADE

EPI E Z PEN JR

Epifrin

Epiglaufrin

Epinefrin

Epinefrina

Epinephran

Epinephrin

EPINEPHRINE

Epinephrine acetate

Epinephrine bitartrate

EPINEPHRINE HCL

Epinephrine hydrochloride

Epinephrine hydrochloride, racemic mixture

Epinephrine hydrogen tartrate

Epinephrine racemic

Epinephrine, racemic

Epinephrine, racemic mixture

Epinephrinum

Epipen

EPIPEN E Z PEN

Epipen JR

EPIPEN JR.

Epirenan

Epitrate

Eppy

Exadrin

Glauposine

GPPE INH SOLN

Hemisine

Hemostasin

Hemostatin

Hydrochloride, racepinephrine

Hypernephrin

Isoptoepinal

JEXT

L-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol

L-Adrenaline

L-DETHYLAMINOETHANOLCATECHOL

L-Epinephrine

L-Epirenamine

Levoepinephrine

LEVO-METHYLAMINOETHANOLCATECHOL

Levorenen

Levorenin

Levorenine

Levoreninum

L-Methylaminoethanolcatechol

Lyodrin

Lyophrin

Medihaler-epi

Methylarterenol

Micronefrin

Micronephrine

Mixture adrenaline, racemic

Mixture epinephrine, racemic

Mucidrina

Nephridine

Nieraline

NSC-62786

Paranephrin

Primatene

Primatene mist

R-(-)-Epinephrine

Racemic adrenaline

Racemic epinephrine

Racemic mixture adrenaline

Racemic mixture epinephrine

Racepinefrina

Racepinefrine

Racepinefrinum

Racepinephrine

Racepinephrine hydrochloride

Renaglandin

Renaleptine

Renalina

Renoform

Renostypticin

Renostyptin

RIDDOBRON

RIDDOFAN

RYBARVIN

Scurenaline

Simplene

SOLN MADE TO RYBARVIN FOR

Styptirenal

Supracapsulin

Supranephrane

Suprarenaline

Suprarenin

Surrenine

Sus-phrine

SUS-PHRINE SULFITE FREE

SUS-PHRINE SULFITE-FREE

SYMJEPI

Takamina

TWINJECT

TWINJECT 0.15

TWINJECT 0.3

Vaponefrin

Vasoconstrictine

Vasotonin

9

Epinephryl borate

Phase 1

10

Anesthetics, Intravenous

Phase 1

11

Anesthetics, General

Phase 1

Interventional clinical trials:

(show all 13)

#	Name	Status	NCT ID	Phase	Drugs
1	Ultrasound-guided Greater Occipital Nerve Block in Children Undergoing Posterior Fossa Craniotomy: Randomized, Controlled Study	Completed	NCT03762343	Phase 3	ultrasound guided Greater occipital nerve block;control group C
2	The Effects of Scalp Block on Haemodynamic Response and Postoperative Pain in	Completed	NCT02852382	Phase 2	Bupivacaine;morphine patient controlled analgesia
3	Efficacy of Intravenous Acetaminophen as Analgesic Adjuvant Therapy in Children Undergoing Posterior Fossa Surgery	Withdrawn	NCT02532322	Phase 2	IV acetaminophen;normal saline
4	Partial Scalp Block Versus Fentanyl Infusion in Patients Undergoing Posterior Fossa Surgery Under General Anesthesia. A Randomized Control Trial	Completed	NCT04955236	Phase 1	Partial scalp block;Fentanyl
5	Effects of the Prone and the Sitting Positions on the Brain Oxygenation in Posterior Fossa Surgery	Unknown status	NCT02933749
6	Child's Study of the Distant Impact of Posterior Fossa Injury on Motor Skills, Language, Cognitive Functioning, and Social Cognition - a Combination of Clinical Assessments and Brain Imaging	Unknown status	NCT04174820
7	The ASsessment and Physiotherapy managEment of Ataxia in Children Following Surgical Resection of Posterior Fossa Tumour (ASPECT)	Unknown status	NCT03945682
8	The Effect of Different Ventilation Strategies on Cerebral Oxygenation Using Near Infrared Spectroscopy (NIRS) in Pediatrics Undergoing Posterior Fossa Tumor Surgery: Randomized Controlled Cross Over Study	Completed	NCT04232059
9	An International, Multisociety Practice Survey Of Extubation Following Elective Infratentorial Craniotomy In Adult Neurosurgical Patients	Completed	NCT05192733
10	The Effect of Cognitive and Motor Training on Executive Functions, Motor Skills, and Saccadic Eye Movements System in Pediatric Posterior Fossa Tumor Survivors	Completed	NCT03951246
11	Advanced MRI in Surgery for Posterior Fossa Tumours - Predicting Post-operative Paediatric Cerebellar Mutism Syndrome and Surgical Guidance to Avoid it	Completed	NCT03471026
12	Impact of Physical Activity on Postural Stability and Coordination in Children With Posterior Fossa Tumor	Completed	NCT04528316
13	Nordic Study of the Cerebellar Mutism Syndrome in Children With Brain Tumours of the Posterior Fossa	Recruiting	NCT02300766

Search NIH Clinical Center for Infratentorial Cancer

Cochrane evidence based reviews: infratentorial neoplasms

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Genetic Tests for Infratentorial Cancer

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Anatomical Context for Infratentorial Cancer

Organs/tissues related to Infratentorial Cancer:

FMA: Infratentorial Region

MalaCards : Brain, Eye, Cerebellum

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Publications for Infratentorial Cancer

Articles related to Infratentorial Cancer:

#	Title	Authors	PMID	Year
1	Safety and efficacy of oncolytic HSV-1 G207 inoculated into the cerebellum of mice. ⁶²	Bernstock JD...Friedman GK	30918335	2020
2	[Lumbar meningeal enhancement after surgery in the posterior cranial fossa: a normal finding in children?]. ⁶²	Krampla W...Hruby W	12471522	2002

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Genes for Infratentorial Cancer

Genes related to Infratentorial Cancer (0 elite genes):

(show top 50) (show all 65)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	KDM4C	Lysine Demethylase 4C	Protein Coding	11.16	DISEASES inferred ¹⁴ ¹⁴
2	H2AC18	H2A Clustered Histone 18	Protein Coding	10.11	DISEASES inferred ¹⁴ ¹⁴
3	MIR9-1	MicroRNA 9-1	RNA Gene	9.7	DISEASES inferred ¹⁴ ¹⁴
4	SHH	Sonic Hedgehog Signaling Molecule	Protein Coding	9.29	DISEASES inferred ¹⁴
5	APC	APC Regulator Of WNT Signaling Pathway	Protein Coding	9.06	DISEASES inferred ¹⁴ ¹⁴
6	PTCH1	Patched 1	Protein Coding	8.93	DISEASES inferred ¹⁴
7	MIR17	MicroRNA 17	RNA Gene	8.74	DISEASES inferred ¹⁴ ¹⁴
8	GLI1	GLI Family Zinc Finger 1	Protein Coding	8.47	DISEASES inferred ¹⁴
9	MIR155	MicroRNA 155	RNA Gene	8.33	DISEASES inferred ¹⁴ ¹⁴
10	MIR324	MicroRNA 324	RNA Gene	8.31	DISEASES inferred ¹⁴ ¹⁴
11	MIR25	MicroRNA 25	RNA Gene	8.31	DISEASES inferred ¹⁴ ¹⁴
12	SUFU	SUFU Negative Regulator Of Hedgehog Signaling	Protein Coding	8.29	DISEASES inferred ¹⁴
13	MYCN	MYCN Proto-Oncogene, BHLH Transcription Factor	Protein Coding	8.24	DISEASES inferred ¹⁴
14	GLI2	GLI Family Zinc Finger 2	Protein Coding	8.21	DISEASES inferred ¹⁴
15	MIR182	MicroRNA 182	RNA Gene	8.03	DISEASES inferred ¹⁴ ¹⁴
16	TP53	Tumor Protein P53	Protein Coding	7.99	DISEASES inferred ¹⁴
17	MIR125A	MicroRNA 125a	RNA Gene	7.97	DISEASES inferred ¹⁴ ¹⁴
18	MYC	MYC Proto-Oncogene, BHLH Transcription Factor	Protein Coding	7.83	DISEASES inferred ¹⁴
19	U2AF1	U2 Small Nuclear RNA Auxiliary Factor 1	Protein Coding	7.73	DISEASES inferred ¹⁴ ¹⁴
20	MIR199A1	MicroRNA 199a-1	RNA Gene	7.59	DISEASES inferred ¹⁴ ¹⁴
21	GLI3	GLI Family Zinc Finger 3	Protein Coding	7.48	DISEASES inferred ¹⁴
22	CTNNB1	Catenin Beta 1	Protein Coding	7.48	DISEASES inferred ¹⁴
23	MIR96	MicroRNA 96	RNA Gene	7.46	DISEASES inferred ¹⁴ ¹⁴
24	MIR34C	MicroRNA 34c	RNA Gene	7.43	DISEASES inferred ¹⁴ ¹⁴
25	MIR584	MicroRNA 584	RNA Gene	7.43	DISEASES inferred ¹⁴ ¹⁴
26	MIR219A1	MicroRNA 219a-1	RNA Gene	7.41	DISEASES inferred ¹⁴ ¹⁴
27	ATOH1	Atonal BHLH Transcription Factor 1	Protein Coding	7.35	DISEASES inferred ¹⁴
28	PROM1	Prominin 1	Protein Coding	7.27	DISEASES inferred ¹⁴
29	NES	Nestin	Protein Coding	7.25	DISEASES inferred ¹⁴
30	NOTCH1	Notch Receptor 1	Protein Coding	7.24	DISEASES inferred ¹⁴
31	PTCH2	Patched 2	Protein Coding	7.21	DISEASES inferred ¹⁴
32	OTX2	Orthodenticle Homeobox 2	Protein Coding	7.2	DISEASES inferred ¹⁴
33	SMARCB1	SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily B, Member 1	Protein Coding	7.19	DISEASES inferred ¹⁴
34	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	7.17	DISEASES inferred ¹⁴
35	EGFR	Epidermal Growth Factor Receptor	Protein Coding	7.15	DISEASES inferred ¹⁴
36	H3-3A	H3.3 Histone A	Protein Coding	7.14	DISEASES inferred ¹⁴
37	H3-3B	H3.3 Histone B	Protein Coding	7.14	DISEASES inferred ¹⁴
38	PTEN	Phosphatase And Tensin Homolog	Protein Coding	7.09	DISEASES inferred ¹⁴
39	MIR142	MicroRNA 142	RNA Gene	7.05	DISEASES inferred ¹⁴ ¹⁴
40	MIR330	MicroRNA 330	RNA Gene	7.02	DISEASES inferred ¹⁴ ¹⁴
41	IDH1	Isocitrate Dehydrogenase (NADP(+)) 1	Protein Coding	7	DISEASES inferred ¹⁴
42	SOX2	SRY-Box Transcription Factor 2	Protein Coding	6.99	DISEASES inferred ¹⁴
43	IHH	Indian Hedgehog Signaling Molecule	Protein Coding	6.98	DISEASES inferred ¹⁴
44	MIR100	MicroRNA 100	RNA Gene	6.96	DISEASES inferred ¹⁴ ¹⁴
45	MIR431	MicroRNA 431	RNA Gene	6.95	DISEASES inferred ¹⁴ ¹⁴
46	CCND1	Cyclin D1	Protein Coding	6.9	DISEASES inferred ¹⁴
47	BMI1	BMI1 Proto-Oncogene, Polycomb Ring Finger	Protein Coding	6.89	DISEASES inferred ¹⁴
48	GFAP	Glial Fibrillary Acidic Protein	Protein Coding	6.83	DISEASES inferred ¹⁴
49	OLIG2	Oligodendrocyte Transcription Factor 2	Protein Coding	6.81	DISEASES inferred ¹⁴
50	DHH	Desert Hedgehog Signaling Molecule	Protein Coding	6.8	DISEASES inferred ¹⁴

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Variations for Infratentorial Cancer

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Expression for Infratentorial Cancer

Search GEO for disease gene expression data for Infratentorial Cancer.

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Pathways for Infratentorial Cancer

Pathways related to Infratentorial Cancer according to GeneCards Suite gene sharing:

(show all 20)

#	Super pathways	Score	Top Affiliating Genes
1	Signal Transduction ⁶⁶	13.61	APC GLI1 GLI2 H2AC18 KDM4C MYC
2	Signaling by Hedgehog ⁶⁶ Show member pathways Hedgehog 'off' state ⁶⁶	12.31	SUFU SHH PTCH1 GLI2 GLI1
3	Wnt / Hedgehog / Notch ³	11.99	APC GLI1 GLI2 PTCH1 SHH SUFU
4	DNA damage response (only ATM dependent) ⁷⁴	11.78	TP53 MYC APC
5	Cell differentiation - expanded index ⁷⁴ Show member pathways Cell differentiation - index ⁷⁴	11.68	MIR9-1 MIR199A1 MIR17 MIR155
6	miRNAs involved in DNA damage response ⁷⁴	11.56	TP53 MYC MIR25 MIR17
7	miRNAs involvement in the immune response in sepsis ⁷⁴	11.54	MIR9-1 MIR199A1 MIR155
8	Hepatitis C and hepatocellular carcinoma ⁷⁴	11.47	TP53 MYC MIR155
9	Development of ureteric collection system ⁷⁴	11.32	SHH MYCN GLI2 GLI1
10	Signaling events mediated by the Hedgehog family ⁶¹ Show member pathways HHAT G278V doesn't palmitoylate Hh-Np ⁶⁶ Ligand-receptor interactions ⁶⁶	11.27	SHH PTCH1 GLI2
11	Tumor suppressor activity of SMARCB1 ⁷⁴ Show member pathways GLI proteins bind promoters of Hh responsive genes to promote transcription ⁶⁶	11.23	PTCH1 GLI2 GLI1
12	Development_Hedgehog and PTH signaling pathways in bone and cartilage development ²²	11.21	SHH PTCH1 GLI2 GLI1
13	Hedgehog signaling pathway ⁷⁴	11.18	SUFU SHH PTCH1 GLI2 GLI1
14	Dopaminergic neurogenesis ⁷⁴	11.16	SHH GLI2 GLI1
15	Hedgehog signaling events mediated by Gli proteins ⁶¹	10.93	SUFU SHH PTCH1 GLI2 GLI1
16	EDA signaling in hair follicle development ⁷⁴	10.62	SHH PTCH1 GLI1
17	Mammary gland development pathway - Involution (Stage 4 of 4) ⁷⁴	10.58	TP53 MYC
18	Glypican 3 network ⁶¹	10.48	SHH PTCH1
19	Hair follicle development: organogenesis - part 2 of 3 ⁷⁴	10.42	SHH PTCH1 MYC GLI2 GLI1
20	Notch Pathway ⁷⁰	10.25	MYCN MYC

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GO Terms for Infratentorial Cancer

Cellular components related to Infratentorial Cancer according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	RISC complex	GO:0016442	9.8	MIR9-1 MIR324 MIR25 MIR199A1 MIR17 MIR155
2	ciliary tip	GO:0097542	9.73	SUFU GLI2 GLI1
3	ciliary base	GO:0097546	9.63	SUFU GLI2 GLI1
4	GLI-SUFU complex	GO:1990788	9.02	SUFU GLI2 GLI1

Biological processes related to Infratentorial Cancer according to GeneCards Suite gene sharing:

(show all 31)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of DNA-templated transcription	GO:0045893	10.5	TP53 SHH PTCH1 MYCN MYC GLI2
2	miRNA-mediated gene silencing	GO:0035195	10.36	MIR125A MIR155 MIR17 MIR182 MIR199A1 MIR25
3	positive regulation of gene expression	GO:0010628	10.32	MIR125A MIR17 MIR182 MYC MYCN SHH
4	negative regulation of canonical Wnt signaling pathway	GO:0090090	10.19	SHH MIR199A1 GLI1 APC
5	branching involved in ureteric bud morphogenesis	GO:0001658	10.11	SHH PTCH1 MYC
6	smoothened signaling pathway	GO:0007224	10.06	GLI1 GLI2 PTCH1 SHH SUFU
7	stem cell proliferation	GO:0072089	10.05	TP53 SHH PTCH1 GLI2
8	embryonic organ development	GO:0048568	10.02	TP53 SHH PTCH1
9	pattern specification process	GO:0007389	10.02	SHH PTCH1 GLI2 APC
10	negative regulation of osteoblast differentiation	GO:0045668	10.01	SUFU PTCH1 MIR9-1 MIR17
11	prostate gland development	GO:0030850	10	GLI1 PTCH1 SHH
12	negative regulation of smoothened signaling pathway	GO:0045879	9.99	SUFU PTCH1 GLI2
13	dorsal/ventral pattern formation	GO:0009953	9.98	SHH PTCH1 GLI2 GLI1
14	spinal cord motor neuron differentiation	GO:0021522	9.97	SHH PTCH1 GLI2
15	cerebellar cortex morphogenesis	GO:0021696	9.91	GLI2 GLI1
16	hindgut morphogenesis	GO:0007442	9.91	GLI2 SHH
17	negative regulation of DNA-binding transcription factor activity	GO:0043433	9.91	MIR125A MIR199A1 MIR9-1 PTCH1 SUFU
18	smoothened signaling pathway involved in ventral spinal cord interneuron specification	GO:0021775	9.9	SUFU GLI2
19	dorsal/ventral neural tube patterning	GO:0021904	9.89	SHH PTCH1 GLI2
20	positive regulation of miRNA maturation	GO:1903800	9.82	TP53 MYCN
21	mammary gland duct morphogenesis	GO:0060603	9.81	GLI2 PTCH1
22	smoothened signaling pathway involved in dorsal/ventral neural tube patterning	GO:0060831	9.8	SUFU GLI2
23	smoothened signaling pathway involved in spinal cord motor neuron cell fate specification	GO:0021776	9.76	SUFU GLI2
24	notochord regression	GO:0060032	9.73	GLI2 GLI1
25	negative regulation of vascular endothelial growth factor production	GO:1904046	9.72	MIR199A1 MIR17 MIR125A
26	negative regulation of hh target transcription factor activity	GO:1990787	9.72	SUFU GLI2 GLI1
27	smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation	GO:0021938	9.65	SHH GLI2 GLI1
28	positive regulation of cardiac muscle hypertrophy in response to stress	GO:1903244	9.63	MIR199A1 MIR17
29	spinal cord dorsal/ventral patterning	GO:0021513	9.55	SUFU SHH GLI2
30	ventral midline development	GO:0007418	9.43	SHH GLI2 GLI1
31	negative regulation of gene expression	GO:0010629	9.32	TP53 SHH MYCN MIR9-1 MIR199A1 MIR17

Molecular functions related to Infratentorial Cancer according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	mRNA 3'-UTR binding	GO:0003730	9.5	TP53 MIR9-1 MIR199A1 MIR17 MIR155 MIR125A
2	mRNA base-pairing translational repressor activity	GO:1903231	9.17	MIR9-1 MIR25 MIR199A1 MIR182 MIR17 MIR155

Sources

Sources for Infratentorial Cancer

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: INF039 MIFTS: 39	Infratentorial Cancer Categories: Cancer diseases, Neuronal diseases	Data Licensing For inquiries, contact: [email protected]
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