MCID: INF039
MIFTS: 39

Infratentorial Cancer

Categories: Cancer diseases, Neuronal diseases
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Aliases & Classifications for Infratentorial Cancer

MalaCards integrated aliases for Infratentorial Cancer:

Name: Infratentorial Cancer 11 14 71
Infratentorial Neoplasms 43 71
Malignant Infratentorial Tumors 11
Brain Neoplasm, Infratentorial 11

Classifications:



External Ids:

Disease Ontology 11 DOID:4706
MeSH 43 D015192
NCIt 49 C3139 C4966
ICD10 31 C71.7
UMLS 71 C0021432 C0751593

Summaries for Infratentorial Cancer

Disease Ontology: 11 A brain cancer that is located in the infratentorial region.

MalaCards based summary: Infratentorial Cancer, also known as infratentorial neoplasms, is related to medulloblastoma and blastoma. An important gene associated with Infratentorial Cancer is KDM4C (Lysine Demethylase 4C), and among its related pathways/superpathways are Signal Transduction and Signaling by Hedgehog. The drugs Bupivacaine and Fentanyl have been mentioned in the context of this disorder. Affiliated tissues include infratentorial region, brain and eye, and related phenotypes are normal and neoplasm

Related Diseases for Infratentorial Cancer

Diseases related to Infratentorial Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 355)
# Related Disease Score Top Affiliating Genes
1 medulloblastoma 31.9 TP53 SUFU SHH PTCH1 MYCN MYC
2 blastoma 10.5 TP53 SHH MYCN
3 holoprosencephaly, recurrent infections, and monocytosis 10.5 PTCH1 GLI2
4 acrocapitofemoral dysplasia 10.5 SHH PTCH1 GLI1
5 fetal alcohol syndrome 10.5 SHH MIR9-1 KDM4C H2AC18
6 holoprosencephaly 11 10.5 SHH PTCH1 GLI2
7 midline interhemispheric variant of holoprosencephaly 10.5 SHH PTCH1 GLI2
8 septopreoptic holoprosencephaly 10.5 SHH PTCH1 GLI2
9 fetal alcohol spectrum disorder 10.5 SHH MIR9-1 KDM4C H2AC18
10 vulva basal cell carcinoma 10.5 SHH PTCH1 MYC
11 basosquamous carcinoma 10.5 TP53 PTCH1 GLI1
12 alobar holoprosencephaly 10.5 SHH PTCH1 GLI2
13 lobar holoprosencephaly 10.5 SHH PTCH1 GLI2
14 medullomyoblastoma 10.5 SUFU SHH MYC
15 holoprosencephaly 3 10.5 SHH PTCH1 GLI2
16 primary ovarian insufficiency 6 10.5 SUFU SHH
17 semilobar holoprosencephaly 10.5 SHH PTCH1 GLI2
18 diffuse astrocytoma 10.5 TP53 KDM4C H2AC18
19 solitary median maxillary central incisor 10.5 SHH PTCH1 GLI2
20 holoprosencephaly 10.5 SHH PTCH1 GLI2 GLI1
21 vacterl association 10.5 SHH GLI2 GLI1
22 central nervous system primitive neuroectodermal neoplasm 10.5 TP53 SHH MYCN
23 microform holoprosencephaly 10.5 SUFU SHH PTCH1 GLI2
24 glioma 10.5 TP53 MIR25 MIR17 GLI1
25 joubert syndrome 8 10.5 SUFU SHH PTCH1 GLI2
26 primary mediastinal b-cell lymphoma 10.5 MYC MIR9-1 MIR155 KDM4C
27 brachydactyly, type a1 10.5 SHH PTCH1 GLI1
28 chromosomal deletion syndrome 10.5 MIR9-1 MIR17 KDM4C H2AC18
29 penis carcinoma in situ 10.5 TP53 SUFU PTCH1 GLI1
30 pineoblastoma 10.5 TP53 SHH MYCN
31 central nervous system hematologic cancer 10.5 MYC MIR9-1 KDM4C
32 serous cystadenocarcinoma 10.5 TP53 MIR199A1 H2AC18
33 micronodular basal cell carcinoma 10.5 TP53 SHH PTCH1 GLI2
34 anus, imperforate 10.5 SHH GLI2 GLI1
35 frontal lobe neoplasm 10.5 TP53 MYCN MYC
36 histone mutated tumor 10.5 TP53 MYCN H2AC18
37 cerebral ventricle cancer 10.5 TP53 SHH MYCN
38 diffuse midline glioma, h3 k27m-mutant 10.5 TP53 MYCN H2AC18
39 supratentorial cancer 10.5 TP53 SHH MYCN H2AC18
40 pallister-hall syndrome 10.5 SHH PTCH1 GLI2 GLI1
41 primary cutaneous t-cell non-hodgkin lymphoma 10.5 MIR17 MIR155 KDM4C H2AC18
42 anus disease 10.5 TP53 SHH H2AC18
43 nut midline carcinoma 10.5 MYC KDM4C H2AC18
44 rhabdoid cancer 10.5 TP53 SHH MIR9-1 KDM4C H2AC18
45 acrocallosal syndrome 10.5 SUFU SHH GLI1
46 cerebrum cancer 10.5 TP53 SHH MYCN
47 estrogen-receptor negative breast cancer 10.5 TP53 MYC H2AC18
48 polydactyly, preaxial ii 10.5 SHH PTCH1
49 lung adenoma 10.5 TP53 MYC H2AC18
50 connective tissue benign neoplasm 10.5 TP53 PTCH1 H2AC18

Graphical network of the top 20 diseases related to Infratentorial Cancer:



Diseases related to Infratentorial Cancer

Symptoms & Phenotypes for Infratentorial Cancer

MGI Mouse Phenotypes related to Infratentorial Cancer:

45 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 normal MP:0002873 10.2 APC GLI1 GLI2 MIR155 MIR182 MYC
2 neoplasm MP:0002006 10.18 APC GLI1 KDM4C MIR182 MYC PTCH1
3 no phenotypic analysis MP:0003012 10.17 GLI1 GLI2 KDM4C MIR199A1 MIR9-1 MYC
4 limbs/digits/tail MP:0005371 10.06 APC GLI1 GLI2 MYC MYCN PTCH1
5 pigmentation MP:0001186 9.97 APC MYC PTCH1 SUFU TP53 U2AF1
6 embryo MP:0005380 9.97 APC GLI1 GLI2 MYC MYCN PTCH1
7 digestive/alimentary MP:0005381 9.96 APC GLI1 GLI2 MIR155 MYC MYCN
8 hearing/vestibular/ear MP:0005377 9.91 APC GLI2 MYC PTCH1 SHH TP53
9 craniofacial MP:0005382 9.81 APC GLI1 GLI2 MYC MYCN PTCH1
10 respiratory system MP:0005388 9.56 GLI1 GLI2 MIR155 MYCN PTCH1 SHH
11 integument MP:0010771 9.28 APC GLI2 KDM4C MYC PTCH1 SHH

Drugs & Therapeutics for Infratentorial Cancer

Drugs for Infratentorial Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bupivacaine Approved, Investigational Phase 3 2180-92-9, 38396-39-3 2474
2
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
3
Morphine Approved, Investigational Phase 2 57-27-2 5288826
4 Anesthetics, Local Phase 2
5 Anesthetics Phase 2
6 Analgesics, Opioid Phase 2
7 Narcotics Phase 2
8
Racepinephrine Approved, Vet_approved Phase 1 51-43-4, 329-65-7 838 5816
9 Epinephryl borate Phase 1
10 Anesthetics, Intravenous Phase 1
11 Anesthetics, General Phase 1

Interventional clinical trials:

(show all 13)
# Name Status NCT ID Phase Drugs
1 Ultrasound-guided Greater Occipital Nerve Block in Children Undergoing Posterior Fossa Craniotomy: Randomized, Controlled Study Completed NCT03762343 Phase 3 ultrasound guided Greater occipital nerve block;control group C
2 The Effects of Scalp Block on Haemodynamic Response and Postoperative Pain in Completed NCT02852382 Phase 2 Bupivacaine;morphine patient controlled analgesia
3 Efficacy of Intravenous Acetaminophen as Analgesic Adjuvant Therapy in Children Undergoing Posterior Fossa Surgery Withdrawn NCT02532322 Phase 2 IV acetaminophen;normal saline
4 Partial Scalp Block Versus Fentanyl Infusion in Patients Undergoing Posterior Fossa Surgery Under General Anesthesia. A Randomized Control Trial Completed NCT04955236 Phase 1 Partial scalp block;Fentanyl
5 Effects of the Prone and the Sitting Positions on the Brain Oxygenation in Posterior Fossa Surgery Unknown status NCT02933749
6 Child's Study of the Distant Impact of Posterior Fossa Injury on Motor Skills, Language, Cognitive Functioning, and Social Cognition - a Combination of Clinical Assessments and Brain Imaging Unknown status NCT04174820
7 The ASsessment and Physiotherapy managEment of Ataxia in Children Following Surgical Resection of Posterior Fossa Tumour (ASPECT) Unknown status NCT03945682
8 The Effect of Different Ventilation Strategies on Cerebral Oxygenation Using Near Infrared Spectroscopy (NIRS) in Pediatrics Undergoing Posterior Fossa Tumor Surgery: Randomized Controlled Cross Over Study Completed NCT04232059
9 An International, Multisociety Practice Survey Of Extubation Following Elective Infratentorial Craniotomy In Adult Neurosurgical Patients Completed NCT05192733
10 The Effect of Cognitive and Motor Training on Executive Functions, Motor Skills, and Saccadic Eye Movements System in Pediatric Posterior Fossa Tumor Survivors Completed NCT03951246
11 Advanced MRI in Surgery for Posterior Fossa Tumours - Predicting Post-operative Paediatric Cerebellar Mutism Syndrome and Surgical Guidance to Avoid it Completed NCT03471026
12 Impact of Physical Activity on Postural Stability and Coordination in Children With Posterior Fossa Tumor Completed NCT04528316
13 Nordic Study of the Cerebellar Mutism Syndrome in Children With Brain Tumours of the Posterior Fossa Recruiting NCT02300766

Search NIH Clinical Center for Infratentorial Cancer

Cochrane evidence based reviews: infratentorial neoplasms

Genetic Tests for Infratentorial Cancer

Anatomical Context for Infratentorial Cancer

Organs/tissues related to Infratentorial Cancer:

FMA: Infratentorial Region
MalaCards : Brain, Eye, Cerebellum

Publications for Infratentorial Cancer

Articles related to Infratentorial Cancer:

# Title Authors PMID Year
1
Safety and efficacy of oncolytic HSV-1 G207 inoculated into the cerebellum of mice. 62
30918335 2020
2
[Lumbar meningeal enhancement after surgery in the posterior cranial fossa: a normal finding in children?]. 62
12471522 2002

Variations for Infratentorial Cancer

Expression for Infratentorial Cancer

Search GEO for disease gene expression data for Infratentorial Cancer.

Pathways for Infratentorial Cancer

Pathways related to Infratentorial Cancer according to GeneCards Suite gene sharing:

(show all 20)
# Super pathways Score Top Affiliating Genes
1 13.61 APC GLI1 GLI2 H2AC18 KDM4C MYC
2
Show member pathways
12.31 SUFU SHH PTCH1 GLI2 GLI1
3 11.99 APC GLI1 GLI2 PTCH1 SHH SUFU
4 11.78 TP53 MYC APC
5
Show member pathways
11.68 MIR9-1 MIR199A1 MIR17 MIR155
6 11.56 TP53 MYC MIR25 MIR17
7 11.54 MIR9-1 MIR199A1 MIR155
8 11.47 TP53 MYC MIR155
9 11.32 SHH MYCN GLI2 GLI1
10
Show member pathways
11.27 SHH PTCH1 GLI2
11
Show member pathways
11.23 PTCH1 GLI2 GLI1
12 11.21 SHH PTCH1 GLI2 GLI1
13 11.18 SUFU SHH PTCH1 GLI2 GLI1
14 11.16 SHH GLI2 GLI1
15 10.93 SUFU SHH PTCH1 GLI2 GLI1
16 10.62 SHH PTCH1 GLI1
17 10.58 TP53 MYC
18 10.48 SHH PTCH1
19 10.42 SHH PTCH1 MYC GLI2 GLI1
20 10.25 MYCN MYC

GO Terms for Infratentorial Cancer

Cellular components related to Infratentorial Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RISC complex GO:0016442 9.8 MIR9-1 MIR324 MIR25 MIR199A1 MIR17 MIR155
2 ciliary tip GO:0097542 9.73 SUFU GLI2 GLI1
3 ciliary base GO:0097546 9.63 SUFU GLI2 GLI1
4 GLI-SUFU complex GO:1990788 9.02 SUFU GLI2 GLI1

Biological processes related to Infratentorial Cancer according to GeneCards Suite gene sharing:

(show all 31)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of DNA-templated transcription GO:0045893 10.5 TP53 SHH PTCH1 MYCN MYC GLI2
2 miRNA-mediated gene silencing GO:0035195 10.36 MIR125A MIR155 MIR17 MIR182 MIR199A1 MIR25
3 positive regulation of gene expression GO:0010628 10.32 MIR125A MIR17 MIR182 MYC MYCN SHH
4 negative regulation of canonical Wnt signaling pathway GO:0090090 10.19 SHH MIR199A1 GLI1 APC
5 branching involved in ureteric bud morphogenesis GO:0001658 10.11 SHH PTCH1 MYC
6 smoothened signaling pathway GO:0007224 10.06 GLI1 GLI2 PTCH1 SHH SUFU
7 stem cell proliferation GO:0072089 10.05 TP53 SHH PTCH1 GLI2
8 embryonic organ development GO:0048568 10.02 TP53 SHH PTCH1
9 pattern specification process GO:0007389 10.02 SHH PTCH1 GLI2 APC
10 negative regulation of osteoblast differentiation GO:0045668 10.01 SUFU PTCH1 MIR9-1 MIR17
11 prostate gland development GO:0030850 10 GLI1 PTCH1 SHH
12 negative regulation of smoothened signaling pathway GO:0045879 9.99 SUFU PTCH1 GLI2
13 dorsal/ventral pattern formation GO:0009953 9.98 SHH PTCH1 GLI2 GLI1
14 spinal cord motor neuron differentiation GO:0021522 9.97 SHH PTCH1 GLI2
15 cerebellar cortex morphogenesis GO:0021696 9.91 GLI2 GLI1
16 hindgut morphogenesis GO:0007442 9.91 GLI2 SHH
17 negative regulation of DNA-binding transcription factor activity GO:0043433 9.91 MIR125A MIR199A1 MIR9-1 PTCH1 SUFU
18 smoothened signaling pathway involved in ventral spinal cord interneuron specification GO:0021775 9.9 SUFU GLI2
19 dorsal/ventral neural tube patterning GO:0021904 9.89 SHH PTCH1 GLI2
20 positive regulation of miRNA maturation GO:1903800 9.82 TP53 MYCN
21 mammary gland duct morphogenesis GO:0060603 9.81 GLI2 PTCH1
22 smoothened signaling pathway involved in dorsal/ventral neural tube patterning GO:0060831 9.8 SUFU GLI2
23 smoothened signaling pathway involved in spinal cord motor neuron cell fate specification GO:0021776 9.76 SUFU GLI2
24 notochord regression GO:0060032 9.73 GLI2 GLI1
25 negative regulation of vascular endothelial growth factor production GO:1904046 9.72 MIR199A1 MIR17 MIR125A
26 negative regulation of hh target transcription factor activity GO:1990787 9.72 SUFU GLI2 GLI1
27 smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation GO:0021938 9.65 SHH GLI2 GLI1
28 positive regulation of cardiac muscle hypertrophy in response to stress GO:1903244 9.63 MIR199A1 MIR17
29 spinal cord dorsal/ventral patterning GO:0021513 9.55 SUFU SHH GLI2
30 ventral midline development GO:0007418 9.43 SHH GLI2 GLI1
31 negative regulation of gene expression GO:0010629 9.32 TP53 SHH MYCN MIR9-1 MIR199A1 MIR17

Molecular functions related to Infratentorial Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA 3'-UTR binding GO:0003730 9.5 TP53 MIR9-1 MIR199A1 MIR17 MIR155 MIR125A
2 mRNA base-pairing translational repressor activity GO:1903231 9.17 MIR9-1 MIR25 MIR199A1 MIR182 MIR17 MIR155

Sources for Infratentorial Cancer

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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