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MCID: ING001
MIFTS: 59

Inguinal Hernia

Categories: Gastrointestinal diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Inguinal Hernia

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MalaCards integrated aliases for Inguinal Hernia:

Name: Inguinal Hernia 12 74 29 6 15 32
Hernia, Inguinal 44
Inguinal Hernias 15
Hernia Inguinal 54

Classifications:

MalaCards categories:
Anatomical: Gastrointestinal diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:0060320
ICD9CM 34 550
MeSH 44 D006552
SNOMED-CT 67 155738001 196800008
UMLS 71 C0019294 C0019295 C0019296
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Summaries for Inguinal Hernia

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Disease Ontology : 12 An intestinal disease characterized by a protrusion of abdominal cavity contests through the inguinal canal.

MalaCards based summary : Inguinal Hernia, also known as hernia, inguinal, is related to arterial tortuosity syndrome and autosomal recessive cutis laxa type i. An important gene associated with Inguinal Hernia is EFEMP1 (EGF Containing Fibulin Extracellular Matrix Protein 1), and among its related pathways/superpathways are Integrin Pathway and Phospholipase-C Pathway. The drugs Ketorolac and Caffeine have been mentioned in the context of this disorder. Affiliated tissues include testis, colon and appendix, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : 74 An inguinal hernia is a protrusion of abdominal-cavity contents through the inguinal canal. Symptoms are... more...

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Related Diseases for Inguinal Hernia

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Diseases related to Inguinal Hernia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 629)
# Related Disease Score Top Affiliating Genes
1 arterial tortuosity syndrome 32.5 FBN1 FBLN5 ELN
2 autosomal recessive cutis laxa type i 32.4 FBN1 FBLN5 ELN
3 cutis laxa 32.3 MMP9 MMP2 FBN1 FBLN5 ELN COL5A1
4 familial thoracic aortic aneurysm and aortic dissection 32.3 FBN1 ELN COL5A1
5 aortic aneurysm 31.5 MMP9 MMP2 MMP13 IL6 FBN1 FBLN5
6 diverticulitis 31.5 MMP9 MMP13 IL6
7 umbilical hernia 31.4 FBN1 ARVCF ACTL6A
8 aneurysm 31.4 NF1 MMP9 MMP13 FBN1 FBLN5 ELN
9 bladder diverticulum 31.4 FBLN5 ELN EFEMP1
10 aortic aneurysm, familial abdominal, 1 31.4 TIMP2 MMP9 MMP2 MMP13 MMP1 IL6
11 bone inflammation disease 31.2 MMP9 MMP13 MMP1 IL6
12 varicose veins 31.2 TIMP2 MMP9 MMP2 MMP1 IL6 FBN1
13 pneumothorax 31.1 TIMP2 MMP9 MMP2 MMP1 FBN1 FBLN5
14 hydronephrosis 31.0 MMP9 IL6 FBN1
15 connective tissue disease 30.9 MMP13 IL6 FBN1 FBLN5 ELN COL5A1
16 pulmonary disease, chronic obstructive 30.8 MMP9 MMP1 IL6 ELN
17 hypermobile ehlers-danlos syndrome 30.8 FBN1 EFEMP1 COL5A1
18 neuroma 30.7 NF1 IL6 CALCA
19 heart disease 30.7 TIMP2 MMP9 MMP2 MMP1 IL6 FBN1
20 chronic kidney disease 30.7 WT1 MMP9 MMP2 IL6 ELN
21 brittle bone disorder 30.6 MMP13 FBN1 ELN COL5A1 CALCA
22 cerebral aneurysms 30.6 MMP2 IL6 ELN
23 venous insufficiency 30.6 MMP9 MMP1 ELN
24 lymphangioleiomyomatosis 30.6 MMP9 MMP2 MMP1 ELN
25 chronic venous insufficiency 30.6 TIMP2 MMP9 MMP1
26 exfoliation syndrome 30.6 MMP1 FBN1 ELN
27 gastrointestinal stromal tumor 30.6 WT1 NF1 MMP9 MMP2
28 aortic disease 30.5 MMP9 IL6 FBN1 ELN
29 gastric ulcer 30.5 MMP9 IL6 CALCA
30 marfan syndrome 30.5 MMP2 MMP1 FBN1 ELN COL5A1
31 pyelonephritis 30.5 MMP9 IL6 CALCA
32 atrial heart septal defect 30.5 FBN1 ELN ACTL6A
33 synovitis 30.5 TIMP2 MMP9 MMP13 MMP1 IL6
34 osteoarthritis 30.5 MMP9 MMP13 MMP1 IL6
35 williams-beuren syndrome 30.5 MMP9 MMP2 FBN1 ELN CALCA
36 myopia 30.5 TIMP2 MMP9 MMP2 MMP1 FBN1 CEMIP2
37 orthostatic intolerance 30.5 FBN1 ELN COL5A1
38 osteogenic sarcoma 30.4 WT1 MMP9 MMP2 IL6
39 diaphragmatic hernia, congenital 30.4 WT1 FBN1 ELN
40 inflammatory bowel disease 30.1 MMP9 MMP2 MMP13 MMP1 IL6 CALCA
41 arthrogryposis multiplex with deafness, inguinal hernias, and early death 11.4
42 lambert syndrome 11.4
43 persistent mullerian duct syndrome 11.4
44 spondylocostal dysostosis 3, autosomal recessive 11.3
45 mucopolysaccharidosis, type ii 11.2
46 cutis laxa, autosomal recessive, type ia 11.2
47 aarskog-scott syndrome 11.2
48 opitz-kaveggia syndrome 11.2
49 achondrogenesis, type ib 11.2
50 marfanoid habitus-inguinal hernia-advanced bone age syndrome 11.2

Graphical network of the top 20 diseases related to Inguinal Hernia:



Diseases related to Inguinal Hernia
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Symptoms & Phenotypes for Inguinal Hernia

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GenomeRNAi Phenotypes related to Inguinal Hernia according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00221-A-1 9.53 NF1
2 Decreased viability GR00221-A-2 9.53 NF1
3 Decreased viability GR00221-A-4 9.53 NF1
4 Decreased viability GR00240-S-1 9.53 ACTL6A
5 Decreased viability GR00249-S 9.53 ACTL6A EBF2 NF1
6 Decreased viability GR00381-A-1 9.53 ARVCF CALCA WT1
7 Decreased viability GR00386-A-1 9.53 ELN NF1
8 Decreased viability GR00402-S-2 9.53 EBF2 ELN FBLN5 FBN1
9 Decreased sensitivity to paclitaxel GR00112-A-0 8.96 NF1 WT1

MGI Mouse Phenotypes related to Inguinal Hernia:

46 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.36 ADAMTS6 AR COL5A1 EBF2 EFEMP1 FBLN5
2 growth/size/body region MP:0005378 10.32 ADAMTS6 AR COL5A1 EBF2 EFEMP1 FBLN5
3 homeostasis/metabolism MP:0005376 10.28 ADAMTS6 AR ARVCF EFEMP1 FBLN5 FBN1
4 hematopoietic system MP:0005397 10.23 ACTL6A ADAMTS6 AR EBF2 EFEMP1 FBN1
5 immune system MP:0005387 10.18 ACTL6A ADAMTS6 AR EFEMP1 FBN1 IL6
6 craniofacial MP:0005382 10.04 ADAMTS6 AR EBF2 FBLN5 FBN1 MMP2
7 integument MP:0010771 10.02 AR COL5A1 EFEMP1 FBLN5 FBN1 IL6
8 muscle MP:0005369 9.91 AR EFEMP1 FBLN5 FBN1 IL6 MMP2
9 limbs/digits/tail MP:0005371 9.87 ADAMTS6 AR EBF2 FBN1 MMP13 MMP9
10 neoplasm MP:0002006 9.76 AR FBLN5 IL6 MMP1 MMP2 MMP9
11 respiratory system MP:0005388 9.56 EBF2 FBLN5 FBN1 IL6 MMP2 MMP9
12 skeleton MP:0005390 9.32 ADAMTS6 AR EBF2 EFEMP1 FBN1 IL6
Sources

Drugs & Therapeutics for Inguinal Hernia

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Drugs for Inguinal Hernia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 143)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
2
Caffeine Approved Phase 4 58-08-2 2519
3
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
4
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
5
Cefazolin Approved Phase 4 25953-19-9 656510 33255
6
Tizanidine Approved, Investigational Phase 4 51322-75-9 5487
7
Acetaminophen Approved Phase 4 103-90-2 1983
8
Bupivacaine Approved, Investigational Phase 4 38396-39-3, 2180-92-9 2474
9
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
10
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
11
Ibuprofen Approved Phase 4 15687-27-1 3672
12
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
13
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
14
Procaine Approved, Investigational, Vet_approved Phase 4 59-46-1 4914
15
Chloroprocaine Approved Phase 4 133-16-4 8612
16
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
17
Benzocaine Approved, Investigational Phase 4 1994-09-7, 94-09-7 2337
18
tannic acid Approved Phase 4 1401-55-4
19
Prilocaine Approved Phase 4 721-50-6 4906
20
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
21
Levobupivacaine Approved, Investigational Phase 4 27262-47-1 92253
22
Clonidine Approved Phase 4 4205-90-7 2803
23
Tamsulosin Approved, Investigational Phase 4 106133-20-4 129211
24
Glutamic acid Approved, Nutraceutical Phase 4 56-86-0 33032
25
Imidacloprid Vet_approved Phase 4 105827-78-9 86418
26 Phosphodiesterase Inhibitors Phase 4
27 Central Nervous System Stimulants Phase 4
28 Calcium, Dietary Phase 4
29 Sodium Channel Blockers Phase 4
30 Diuretics, Potassium Sparing Phase 4
31 Anesthetics, Local Phase 4
32 Anti-Arrhythmia Agents Phase 4
33 Anti-Infective Agents Phase 4
34 Gentamicins Phase 4
35 Parasympatholytics Phase 4
36 Analgesics, Non-Narcotic Phase 4
37 Anti-Inflammatory Agents Phase 4
38 Cyclooxygenase Inhibitors Phase 4
39 Anti-Inflammatory Agents, Non-Steroidal Phase 4
40 Antirheumatic Agents Phase 4
41 Antipyretics Phase 4
42 Gastrointestinal Agents Phase 4
43 Hormone Antagonists Phase 4
44 glucocorticoids Phase 4
45 Hormones Phase 4
46 Antineoplastic Agents, Hormonal Phase 4
47 Antiemetics Phase 4
48 Analgesics, Opioid Phase 4
49 Anti-Asthmatic Agents Phase 4
50 Respiratory System Agents Phase 4

Interventional clinical trials:

(show top 50) (show all 366)
# Name Status NCT ID Phase Drugs
1 Rebound Hernia Repair Device Trial Unknown status NCT00968773 Phase 4
2 Early Outcome of Inguinal Hernia Repair With Biomerix Surgical Mesh Using the Lichtenstein Technique Unknown status NCT00924755 Phase 4
3 The Effect of Different Doses of Ketamine on Tracheal Intubating Conditions Using Low Dose Rocuronium in Children Unknown status NCT02646709 Phase 4 Rocuronium;ketamine 1;ketamine 1.5;ketamine 2
4 Does Ultrasound-guided Ilioinguinal-iliohypogastric Block Improve Postoperative Pain Outcome After Unilateral Inguinal Hernia Repair? Unknown status NCT01326039 Phase 4 bupivacaine;saline
5 Chronic Significant Pain and Functional Outcome After Laparoscopic Versus Open Groin Hernia Mesh Repair: Design of a Randomized Controlled Clinical Trial Unknown status NCT00625534 Phase 4
6 Controlled Release of Oxycodone 10 mg In Pre-Medication For The Post Operative Analgesia In Elective Laparoscopic Bilateral Inguinal Hernia And Elective Laparoscopic Cholecystectomy : Prospective Double Blind, Randomized, Placebo-Controlled Study Unknown status NCT00480142 Phase 4 Oxycodone 10 mg
7 The Impact of Perioperative Gabapentin on Chronic Groin Pain After Inguinal Hernia Repair Unknown status NCT02419443 Phase 4 Gabapentin;Placebo
8 Effects of Transverse Abdominis Plane Block Guided by Ultrasound on the Postoperative Analgesia and Quality of Lives Among the Patients Undergo Inguinal Hernia Repair Unknown status NCT02292095 Phase 4
9 Investigating the Effect of Intra-operative Infiltration With Local Anaesthesia on the Development of Chronic Postoperative Pain After Inguinal Hernia Repair. A Randomized Placebo Controlled Triple Blinded and Group Sequential Study Design Unknown status NCT00484731 Phase 4
10 Does the Preoperative Midazolam Dose Affect Postoperative Pain? - a Multicentric Randomized Controlled Trial in Ambulatory Surgery Unknown status NCT03534895 Phase 4 Midazolam Injectable Solution;Postoperative analgesia;Rescue analgesia;Wound infiltration;Analgesia at home
11 Multicentre Randomised Controled Trial Comparing the Effect of a New Self-gripping Lightweight Polyester Mesh and a Normal Sutured Lightweight Polyester Mesh on the Incidence of Chronic Inguinodynia in Lichtenstein Hernioplasty. Unknown status NCT01830452 Phase 4
12 Early and Late Results of Transinguinal Preperitoneal Patch Repair Versus Anterior Pre-Trasversalis Mesh Repair. A Randomised Study Completed NCT01350830 Phase 4
13 Is Topical Antibiotic Prophylaxis Effective in Lichtenstein Hernia Repair: a Comparison Study Completed NCT01273818 Phase 4 Gentamicin and cefazolin;Cefazolin;Gentamicin
14 Investigation of the Effectiveness of Tizanidine on Pain After Herniorrhaphy Completed NCT02016443 Phase 4 Tizanidine;Placebo
15 A Randomized, Phase 4 Study of the Efficacy, Safety, and Pharmacokinetics of Bupivacaine Administered as Liposomal Bupivacaine or Continuous Infusion Via Elastomeric Pump Following Unilateral Open Inguinal Herniorrhaphy Completed NCT04102267 Phase 4 Bupivacaine liposome injectable suspension;Bupivacaine HCl without epinephrine via continuous infusion
16 A Multicenter Prospective Randomized Trial on Chronic Pain After Inguinal Hernia Repair Using a Selfgrip-mesh Completed NCT00820131 Phase 4
17 Prospective, Randomized, Controlled, Third-Party Blinded Multicenter Evaluation of Strattice/LTM in the Repair of Inguinal Hernias Completed NCT00681291 Phase 4
18 Single Dose Antibiotic Prophylaxis in Lihtenstein Repair for Primary Inguinal Hernias Completed NCT01264003 Phase 4 sefazolin
19 Comparing Non-fixation of Mesh to Mesh Fixation in Laparoscopic Total Extraperitoneal Inguinal Hernia Repair Under Spinal Anesthesia- A Randomized Controlled Trial Completed NCT01117337 Phase 4
20 Analgesic Efficacy of Ultrasound-guided Inguinal Field Block (Genitofemoral, Iliohypogastric and Ilioinguinal Nerve Block) for Inguinal Hernia Surgery. Completed NCT01521481 Phase 4
21 Comparison of Postoperative Analgesic Effects of Transversus Abdominis Plane Block and Quadratus Lumborum Block Type 2 Completed NCT03126084 Phase 4 Acetaminophen;0.25% Bupivacaine;0.5% Bupivacaine+Glucose;Tramadol HCl;0.25% Bupivacaine
22 Prolene Hernia System, Lichtenstein Mesh, and Plug-and-Patch for Primary Inguinal Hernia Repair - Three Year Outcome of a Prospective Randomised Controlled Trial Completed NCT00580177 Phase 4
23 Comparative Study of Safety and Efficacy of Heavyweight and Partially Absorbable Mesh in Inguinal Hernia Repair Completed NCT01877122 Phase 4
24 Prospective Randomized, Double-Blind, Controlled Trial Comparing Lichtenstein's Repair of Inguinal Hernia With Polypropylene Mesh Versus Surgisis ES Soft Tissue Graft Completed NCT00614419 Phase 4
25 ProGrip Mesh Repair Versus Lichtenstein Mesh Repair: a Comparative Randomized Study in Primary Inguinal Hernia Completed NCT00827944 Phase 4
26 Comparative Efficacy of Intravenous Acetaminophen vs. Oral Acetaminophen in Ambulatory Surgery Completed NCT03558555 Phase 4 Acetaminophen IV Soln;Oral Acetaminophen;Placebo Pills;Saline
27 Prospective, Controlled, Randomized Study to Evaluate Pain and Further Disabling Complications in Patients Undergoing Lichtenstein Technique for Primary Inguinal Hernia Repair by Fixing the Mesh With Fibrin Sealant Versus Sutures Completed NCT00306839 Phase 4
28 A Multi-site Randomised Controlled Trial Comparing Regional and General Anaesthesia for Effects on Neurodevelopmental Outcome and Apnoea in Infants Completed NCT00756600 Phase 4 Regional Anesthesia;General Anesthesia
29 The Comparison of Two Different Doses of Morphine Added to Spinal Bupivacaine for Inguinal Hernia Repair. Completed NCT02001948 Phase 4 intrathecal morphine 0.1 mg combined with intrathecal heavy bupivacaine 7.5 mg;intrathecal morphine 0.4 mg combined with intrathecal heavy bupivacaine 7.5 mg;intravenous cannulation and premedication
30 A Randomized, Double-blinded, Placebo-controlled Trial of the Effects of Infusing Local Anesthesia on Post-operative Pain During Laparoscopic Inguinal Hernia Repair Completed NCT02055053 Phase 4 0.5% Bupivicaine
31 Lichtenstein's Repair of Inguinal Hernia With Polypropylene Mesh Versus Infinit® PTFE Mesh, a Prospective Randomized, Double-blind, Controlled Trial Completed NCT01141335 Phase 4
32 Comparision of the Use in Marcaine and Chloroprocaine in Rachianesthesia for the Surgical Correction of Inguinal Hernia. Completed NCT02049255 Phase 4 Chloroprocaine;Marcaine
33 Selective Subarachnoid Anesthesia. Comparison of Hyperbaric Bupivacaine and Hyperbaric Prilocaine in Knee Arthroscopy and Inguinal Hernia Repair in Ambulatory Surgery Completed NCT01921231 Phase 4 Hyperbaric Prilocaine 1%;Hyperbaric bupivacaine 0.5%
34 Evaluation of Dexamethasone Added to the Usual Infiltration With Bupivacaine in Inguinal Hernia Repair Mesh Completed NCT03007927 Phase 4 Bupivacaine-Dexamethasone;Bupivacaine- physiological solution
35 Preoperative Administration of Tamsulosin for Prevention of Post Operative Urinary Retention in Males Undergoing Elective Inguinal Hernia Repair Completed NCT02958878 Phase 4 Tamsulosin;Placebo Oral Capsule
36 Determination of the Minimum Local Anesthetic Dose (MLAD) of Spinal Chloroprocaine for Inguinal Herniorrhaphy in Ambulatory Surgery Completed NCT03805503 Phase 4 Chloroprocaine 1% Injectable Solution
37 Evaluation of Postoperative Pain Following Laparoscopic Hernia Repair: A Prospective, Randomized Comparison to Evaluate the Incidence of Post-operative Pain Associated With Absorbable Fixation (AbsorbaTack) vs Conventional Fixation (ProTack) Following Laparoscopic Hernia Repair Completed NCT00749268 Phase 4
38 THE EFFECT OF DIFFERENT INDUCTION TECHNIQUES ON POSTOPERATIVE PAIN AND AGITATION IN CHILDREN Completed NCT02110745 Phase 4 Sevofluorane;Propofol
39 ZIH Study : Comparison of Oral Zaldiar (Combination of Paracetamol and Tramadol) With Intravenous Paracetamol and Tramadol for Postoperative Analgesia After Inguinal Hernia Repair Completed NCT02389361 Phase 4 Zaldiar;Paracetamol-Tramadol
40 The Efficacy of Transversus Abdominis Plane Block Versus Placebo Versus Local Infiltration in Patients Undergoing Groin Hernia Repair in Day Case Surgery. Completed NCT01052285 Phase 4
41 Evaluation of the Analgesic Effect of Tramadol Wound Infiltration in Children Under Inguinal Hernioplasty. A Double-blind, Randomized Study. Completed NCT01943760 Phase 4 tramadol;0.9% saline
42 A Comparison of the Recovery Profiles of Bupivacaine or Bupivacaine Mixed With Lidocaine Spinal Anesthesia and Local Infiltration Anesthesia for Outpatient Herniorrhaphy Completed NCT01548794 Phase 4
43 Randomized, Quadruple Blinded, Placebo Controlled, Multi-centered Trial Investigating Prophylactic Tamsulosin in Prevention of Postoperative Urinary Retention in Men After Endoscopic Total Extraperitoneal Inguinal Hernia Repair Recruiting NCT04491526 Phase 4 TAMSULOSIN Mepha Ret Depocaps 0.4 mg;Control Intervention
44 The Effect of Local Anesthetic and Clonidine on the Cutaneous Silent Period During and After Spinal Anesthesia Active, not recruiting NCT03121261 Phase 4 levobupivacaine;clonidine
45 The Use of Tamsulosin to Prevent Postoperative Urinary Retention in Laparoscopic Inguinal Hernia Repair: A Randomized Double-Blind Placebo-Controlled Study Terminated NCT04434378 Phase 4 Tamsulosin;Placebo
46 Pre-emptive Intravenous Analgesia for Elective Inguinal Hernia Repair: Prospective Randomized Double-blinded Placebo Controlled Comparison of Lornoxicam and Paracetamol Unknown status NCT01069055 Phase 3 Intravenous lornoxicam;Intravenous paracetamol
47 Dexmedetomidine Sedation Versus General Anaesthesia for Inguinal Hernia Surgery on Peri-operative Outcomes and Neurocognitive Development in Infants: A Randomized Controlled Trial Unknown status NCT02559102 Phase 3 Dexmedetomidine sedation;General sevoflurane anaesthesia
48 Use of Acellular Dermal in the Incarcerated Inguinal Hernia Tension-free Reconstructions Unknown status NCT02469142 Phase 2, Phase 3
49 Efficacy of Pre-operative Oral Pregabalin in Ambulatory Inguinal Hernia Repair for Post Operative Pain Unknown status NCT01450345 Phase 3 Pregabalin
50 Laparoscopic-assisted Transversus Abdominis Plane (TAP) Block for Laparoscopic Total Extra Peritoneal (TEP) Inguinal Hernia Repair: a Prospective, Double-blinded, Randomized, Clinical Trial Unknown status NCT02632136 Phase 3 TAP Block Group;Peri-Portal Block Group

Search NIH Clinical Center for Inguinal Hernia

Cochrane evidence based reviews: hernia, inguinal

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Genetic Tests for Inguinal Hernia

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Genetic tests related to Inguinal Hernia:

# Genetic test Affiliating Genes
1 Inguinal Hernia 29
Sources

Anatomical Context for Inguinal Hernia

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MalaCards organs/tissues related to Inguinal Hernia:

40
Testis, Colon, Appendix, Skin, Uterus, Ovary, Kidney
Sources

Publications for Inguinal Hernia

About this section

Articles related to Inguinal Hernia:

(show top 50) (show all 12012)
# Title Authors PMID Year
1
Preoperative oral granisetron for the prevention of vomiting following paediatric surgery. 54 61
11903942 2002
2
A role for the collagen I/III and MMP-1/-13 genes in primary inguinal hernia? 54 61
11872152 2002
3
Prophylactic therapy with combined granisetron and dexamethasone for the prevention of post-operative vomiting in children. 54 61
10434165 1999
4
Synthesis of type I and III collagen, expression of fibronectin and matrix metalloproteinases-1 and -13 in hernial sac of patients with inguinal hernia. 61 54
11341610 1999
5
Granisetron reduces post-operative vomiting in children: a dose-ranging study. 54 61
10084103 1999
6
A preliminary evaluation of two different meshes in minimally invasive inguinal hernia surgery. 61
32232645 2021
7
Correction to: A prospective randomised control trial to compare the perioperative outcomes and ergonomic challenges between triangular versus midline port placement in total extra-peritoneal repair of uncomplicated inguinal hernia. 61
32529353 2021
8
Short- and Long-Term Outcomes of Transabdominal Preperitoneal, Open Mesh Plug and Open Tissue Inguinal Hernia Repair. 61
33216169 2021
9
A prospective randomised control trial to compare the perioperative outcomes and ergonomic challenges between triangular versus midline port placement in total extra-peritoneal repair of uncomplicated unilateral inguinal hernia. 61
32246238 2021
10
Giant Inguinal Hernia in a Decompensated Cirrhotic Patient. 61
31931180 2021
11
The Use of Artificial Neural Network to Predict Surgical Outcomes After Inguinal Hernia Repair. 61
33097206 2021
12
Predictors of chronic pain after laparoscopic inguinal hernia repair. 61
32988621 2021
13
Ultrasound-guided microwave ablation in the treatment of inguinal neuralgia. 61
33000286 2021
14
The most commonly injured nerves at surgery: A comprehensive review. 61
33090551 2021
15
Inguinal hernia of the distal ureter causing hydronephrosis: A rare case. 61
33437644 2021
16
Clinical benefits of routine examination and synchronous repair of occult inguinal hernia during laparoscopic peritoneal dialysis catheter insertion: a single-center experience. 61
33548007 2021
17
Relevance of Antibiotic Prophylaxis in Non-Mesh Inguinal Hernia Repair in Remote and Poor Medical Settings in Sub-Saharan Africa. 61
33538650 2021
18
Laparoscopic repair of recurrent inguinal hernia offers similar outcomes and quality of life to primary laparoscopic repair. 61
32447535 2021
19
Long-term outcomes after bilateral transabdominal preperitoneal (TAPP) repair for asymptomatic contralateral inguinal hernia. 61
32055992 2021
20
If laparoscopic technique can be used for treatment of acutely incarcerated/strangulated inguinal hernia? 61
33549139 2021
21
Long-term Comparison of Recurrence Rates Between Different Lightweight and Heavyweight Meshes in Open Anterior Mesh Inguinal Hernia Repair: A Nationwide Population-based Register Study. 61
30720504 2021
22
Emergency high ligation in a suspected COVID-19 pediatric patient with incarcerated inguinal hernia: A case report. 61
33520222 2021
23
Short-term outcomes of pediatric laparoscopic inguinal hernia repair in Korea based on Korean Health Insurance Big Data: 2011-2015. 61
32253522 2021
24
Optimal Viewing Direction of the Oblique Laparoscope in Single-Incision Laparoscopic Percutaneous Extraperitoneal Closure for Inguinal Hernia. 61
33232635 2021
25
USA Department of Defense audit of surgical antibiotic prophylaxis prescribing patterns in inguinal hernia repair. 61
32107656 2021
26
Risk factors influencing ascending testis after laparoscopic percutaneous extraperitoneal closure for pediatric inguinal hernia and hydrocele. 61
33388952 2021
27
Single-blind randomized clinical trial of transinguinal preperitoneal repair using self-expanding mesh patch vs. Lichtenstein repair for adult male patients with primary unilateral inguinal hernia. 61
32926259 2021
28
Analysis of nursing practice of indirect inguinal hernia in children under the concept of rapid rehabilitation surgery. 61
33555160 2021
29
Enhanced angiogenesis in the 3D dynamic responsive implant for inguinal hernia repair ProFlor®. 61
33529348 2021
30
Malignant haemangiopericytomas of omentum presenting as left inguinal hernia: A case report. 61
33552488 2021
31
Characteristics and treatments for pediatric ordinary and incarcerated inguinal hernia based on gender: 12-year experiences from a single center. 61
33522917 2021
32
Cost analysis of inguinal hernia repair: the influence of clinical and hernia-specific factors. 61
33555463 2021
33
Surgical Management of Pediatric Inguinal Hernia: A Systematic Review and Guideline from the European Pediatric Surgeons' Association Evidence and Guideline Committee. 61
33567466 2021
34
Using Local Anesthesia for Inguinal Hernia Repair Reduces Complications in Older Patients. 61
33002663 2021
35
Inguinal hernia repair among men: development and validation of a preoperative risk score for persistent postoperative pain. 61
33570707 2021
36
Laparoscopic removal of mesh migrating into the sigmoid colon after totally extraperitoneal (TEP) laparoscopic inguinal hernia repair with positive faecal occult blood test. 61
33542008 2021
37
Leiomyosarcoma of the spermatic cord presenting as an incarcerated inguinal hernia: a rare presentation of a rare condition. 61
33585027 2021
38
Genetic Analysis Reveals Complete Androgen Insensitivity Syndrome in Female Children Surgically Treated for Inguinal Hernia. 61
31012339 2021
39
Effect of perineural bupivacaine infiltration on reducing inguinodynia in patients undergoing inguinal meshplasty - a randomized controlled trial. 61
33497295 2021
40
ROBotic Utility for Surgical Treatment of hernias (ROBUST hernia project). 61
33602554 2021
41
Laparoscopic assisted hydrocelectomy of the canal of Nuck: a case report. 61
33599854 2021
42
Impact of Mesh and Fixation on Chronic Inguinal Pain in Lichtenstein Hernia Repair: 5-Year Outcomes from the Finn Mesh Study. 61
33099665 2021
43
A Pilot Study of Surgical Trainee Participation in Humanitarian Surgeries. 61
33588294 2021
44
Impact of policy-based and institutional interventions on postoperative opioid prescribing practices. 61
33593614 2021
45
A Piercing Diagnosis - Occult Foreign Body as the Cause of Acute Inguinal Pain. 61
33560973 2021
46
Chronic postoperative inguinal pain: A narrative review. 61
32386729 2021
47
Global versus task-specific postoperative feedback in surgical procedure learning. 61
33589246 2021
48
Duplicated vas deferens: A case report and comprehensive review of the literature. 61
33167062 2021
49
Modified percutaneous internal ring suturing with peritoneal injury in children: matched comparison to open hernia repair. 61
32076861 2021
50
Technical details and findings during a second Lichtenstein repair or a second laparoscopic repair in the same groin: a study based on medical records. 61
31786701 2021
Sources

Variations for Inguinal Hernia

About this section

ClinVar genetic disease variations for Inguinal Hernia:

6 (show all 11)
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 FBN1 NM_000138.4(FBN1):c.840_843del (p.Asn280fs) Deletion Pathogenic 374115 rs1057518909 15:48826296-48826299 15:48534099-48534102
2 NF1 NM_000267.3(NF1):c.7419G>A (p.Trp2473Ter) SNV Pathogenic 216067 rs863224493 17:29679299-29679299 17:31352281-31352281
3 ARVCF GRCh37/hg19 22q11.21(chr22:18894835-20311763) copy number loss Pathogenic 523273 22:18894835-20311763
4 EFEMP1 NM_001039348.3(EFEMP1):c.320_324del (p.Met107fs) Deletion Pathogenic 691884 rs1572850869 2:56144993-56144997 2:55917858-55917862
5 EFEMP1 NM_001039348.3(EFEMP1):c.615T>A (p.Tyr205Ter) SNV Pathogenic 691885 rs765517862 2:56108772-56108772 2:55881637-55881637
6 CEMIP2 NM_013390.3(CEMIP2):c.1358G>A (p.Cys453Tyr) SNV Pathogenic 827846 9:74349757-74349757 9:71734841-71734841
7 CEMIP2 NM_013390.3(CEMIP2):c.3144G>A (p.Trp1048Ter) SNV Pathogenic 827847 9:74319561-74319561 9:71704645-71704645
8 COL5A1 NM_001278074.1(COL5A1):c.608G>T (p.Gly203Val) SNV Likely pathogenic 523328 rs1554781700 9:137593133-137593133 9:134701287-134701287
9 ACTL6A NM_004301.5(ACTL6A):c.1129C>T (p.Arg377Trp) SNV Likely pathogenic 549661 rs868064163 3:179304340-179304340 3:179586552-179586552
10 ELN NM_000501.4(ELN):c.898A>T (p.Thr300Ser) SNV Uncertain significance 523433 rs766735416 7:73466262-73466262 7:74051932-74051932
11 LSM1 NM_014462.3(LSM1):c.231+4A>C SNV Uncertain significance 623485 rs775468919 8:38027316-38027316 8:38169798-38169798
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Expression for Inguinal Hernia

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Search GEO for disease gene expression data for Inguinal Hernia.
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Pathways for Inguinal Hernia

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Pathways related to Inguinal Hernia according to GeneCards Suite gene sharing:

(show all 23)
# Super pathways Score Top Affiliating Genes
1
Integrin Pathway 63
Show member pathways
 13.25 MMP9 MMP2 MMP13 MMP1 FBN1 ELN
2
Phospholipase-C Pathway 63
Show member pathways
 12.96 TIMP2 IL6 FBN1 ELN EFEMP1 COL5A1
3
Pathways in cancer 36
12.73 MMP9 MMP2 MMP1 IL6 AR
4
IL-17 Family Signaling Pathways 64
Show member pathways
 12.23 MMP9 MMP13 MMP1 IL6
5
Colorectal Cancer Metastasis 63
12.07 MMP9 MMP2 MMP1 IL6
6
Degradation of the extracellular matrix 65
Show member pathways
 11.98 TIMP2 MMP9 MMP2 MMP13 MMP1 FBN1
7
Interleukin-4 and 13 signaling 65
11.84 MMP9 MMP2 MMP1 IL6
8
Angiogenesis (CST) 4
11.71 TIMP2 MMP9 MMP2 MMP13
9
Regulation of Wnt-mediated beta catenin signaling and target gene transcription 1
11.68 MMP9 MMP2 AR
10
Matrix Metalloproteinases 1
Show member pathways
 11.65 TIMP2 MMP9 MMP2 MMP13 MMP1
11
Bladder cancer 36 1
11.64 MMP9 MMP2 MMP1
12
Elastic fibre formation 65
Show member pathways
 11.6 FBN1 FBLN5 ELN EFEMP1
13
AGE/RAGE pathway 1
11.57 MMP9 MMP2 MMP13
14
LPA receptor mediated events 1
11.56 MMP9 MMP2 IL6
15
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.5 MMP9 MMP2 MMP1 IL6
16
ATF-2 transcription factor network 1
11.47 NF1 MMP2 IL6
17
amb2 Integrin signaling 1
11.39 MMP9 MMP2 IL6
18
Transcription_Role of VDR in regulation of genes involved in osteoporosis 23
11.35 IL6 CALCA AR
19
Lung fibrosis 1
11.35 MMP9 MMP2 IL6 ELN CALCA
20
Cell adhesion_Cell-matrix glycoconjugates 23
11.26 TIMP2 MMP9 MMP1 ELN
21
Validated transcriptional targets of AP1 family members Fra1 and Fra2 1
11.15 MMP9 MMP2 MMP1 IL6
22
Cell adhesion_ECM remodeling 23
11.14 TIMP2 MMP9 MMP2 MMP13 MMP1
23
G-protein signaling_Rap2B regulation pathway 23
10.87 TIMP2 IL6 FBN1 ELN EFEMP1 COL5A1
Sources

GO Terms for Inguinal Hernia

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Cellular components related to Inguinal Hernia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.97 TIMP2 MMP9 MMP2 MMP13 MMP1 IL6
2 extracellular space GO:0005615 9.96 TIMP2 MMP9 MMP2 MMP13 IL6 FBN1
3 collagen-containing extracellular matrix GO:0062023 9.56 TIMP2 MMP9 MMP2 FBN1 FBLN5 ELN
4 extracellular matrix GO:0031012 9.36 TIMP2 MMP9 MMP2 MMP13 MMP1 FBN1
5 elastic fiber GO:0071953 9.32 FBLN5 ELN

Biological processes related to Inguinal Hernia according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.88 WT1 TIMP2 NF1 IL6 AR
2 heart development GO:0007507 9.83 WT1 NF1 FBN1 ADAMTS6
3 camera-type eye development GO:0043010 9.63 WT1 FBN1 EFEMP1
4 cellular protein metabolic process GO:0044267 9.63 MMP2 MMP13 MMP1 IL6 FBN1 CALCA
5 embryo implantation GO:0007566 9.58 MMP9 MMP2 CALCA
6 collagen catabolic process GO:0030574 9.56 MMP9 MMP2 MMP13 MMP1
7 regulation of neuroinflammatory response GO:0150077 9.54 MMP9 IL6
8 response to amyloid-beta GO:1904645 9.54 MMP9 MMP2 MMP13
9 embryonic eye morphogenesis GO:0048048 9.51 FBN1 EFEMP1
10 cellular response to UV-A GO:0071492 9.5 MMP9 MMP2 MMP1
11 positive regulation of adenylate cyclase activity GO:0045762 9.49 TIMP2 NF1
12 post-embryonic eye morphogenesis GO:0048050 9.43 FBN1 EFEMP1
13 extracellular matrix disassembly GO:0022617 9.35 TIMP2 MMP9 MMP2 MMP13 MMP1
14 extracellular matrix organization GO:0030198 9.32 NF1 MMP9 MMP2 MMP13 MMP1 FBN1

Molecular functions related to Inguinal Hernia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 zinc ion binding GO:0008270 9.87 WT1 TIMP2 MMP9 MMP2 MMP13 MMP1
2 peptidase activity GO:0008233 9.83 MMP9 MMP2 MMP13 MMP1 ADAMTS6
3 integrin binding GO:0005178 9.71 TIMP2 FBN1 FBLN5 COL5A1
4 extracellular matrix structural constituent GO:0005201 9.67 FBN1 ELN EFEMP1 COL5A1
5 endopeptidase activity GO:0004175 9.56 MMP9 MMP2 MMP13 MMP1
6 metallopeptidase activity GO:0008237 9.55 MMP9 MMP2 MMP13 MMP1 ADAMTS6
7 extracellular matrix constituent conferring elasticity GO:0030023 9.13 FBN1 FBLN5 ELN
8 metalloendopeptidase activity GO:0004222 9.02 MMP9 MMP2 MMP13 MMP1 ADAMTS6
Sources

Sources for Inguinal Hernia

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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