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MCID: ING001
MIFTS: 60

Inguinal Hernia

Categories: Gastrointestinal diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Inguinal Hernia

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MalaCards integrated aliases for Inguinal Hernia:

Name: Inguinal Hernia 12 74 29 6 15 32
Hernia, Inguinal 43
Inguinal Hernias 15
Hernia Inguinal 54

Classifications:

MalaCards categories:
Anatomical: Gastrointestinal diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:0060320
ICD9CM 34 550
MeSH 43 D006552
UMLS 71 C0019294 C0019295 C0019296
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Summaries for Inguinal Hernia

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Disease Ontology : 12 An intestinal disease characterized by a protrusion of abdominal cavity contests through the inguinal canal.

MalaCards based summary : Inguinal Hernia, also known as hernia, inguinal, is related to cutis laxa, autosomal recessive, type ia and autosomal recessive cutis laxa type i. An important gene associated with Inguinal Hernia is EFEMP1 (EGF Containing Fibulin Extracellular Matrix Protein 1), and among its related pathways/superpathways are Integrin Pathway and Phospholipase-C Pathway. The drugs Caffeine and Ethanol have been mentioned in the context of this disorder. Affiliated tissues include testis, colon and skin, and related phenotypes are Decreased sensitivity to paclitaxel and cardiovascular system

Wikipedia : 74 An inguinal hernia is a protrusion of abdominal-cavity contents through the inguinal canal. Symptoms are... more...

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Related Diseases for Inguinal Hernia

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Diseases related to Inguinal Hernia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 616)
# Related Disease Score Top Affiliating Genes
1 cutis laxa, autosomal recessive, type ia 33.2 LOXL1 FBN1 FBLN5
2 autosomal recessive cutis laxa type i 33.0 FBN1 FBLN5 ELN
3 cutis laxa 33.0 MMP9 MMP2 MMP1 LOXL1 FBN1 FBLN5
4 arterial tortuosity syndrome 33.0 FBN1 FBLN5 ELN
5 appendicitis 32.1 TIMP1 MMP9 IL6
6 diverticulitis 31.6 MMP9 MMP13 IL6
7 endometriosis 31.4 TIMP1 MMP2 MMP1 IL6
8 bone inflammation disease 31.3 MMP9 MMP13 MMP1 IL6
9 hydronephrosis 31.3 TIMP1 MMP9 IL6 GATA4 FBN1
10 aortic aneurysm 31.3 TIMP2 TIMP1 MMP9 MMP2 MMP13 IL6
11 aortic aneurysm, familial abdominal, 1 31.3 TIMP2 TIMP1 MMP9 MMP2 MMP13 MMP1
12 connective tissue disease 31.1 MMP13 IL6 FBN1 FBLN5 ELN COL5A1
13 varicose veins 31.1 TIMP2 TIMP1 MMP9 MMP2 MMP1 IL6
14 pneumothorax 31.0 TIMP2 TIMP1 MMP9 MMP2 MMP1 FBN1
15 hypospadias 31.0 WT1 GATA4 AR
16 pulmonary disease, chronic obstructive 30.9 TIMP1 MMP9 MMP1 IL6 ELN
17 neuroma 30.8 NF1 IL6 CALCA
18 cerebral aneurysms 30.8 MMP2 ELN
19 patent ductus arteriosus 1 30.8 GATA4 FBN1 ELN
20 exfoliation syndrome 30.7 MMP1 LOXL1 FBN1 ELN
21 lymphangioleiomyomatosis 30.7 MMP9 MMP2 MMP1 ELN
22 brittle bone disorder 30.7 FBN1 ELN COL5A1 CALCA
23 chronic venous insufficiency 30.7 TIMP2 TIMP1 MMP9 MMP1
24 aortic disease 30.6 MMP9 MMP2 IL6 FBN1 ELN
25 synovitis 30.6 TIMP2 MMP9 MMP13 MMP1 IL6
26 venous insufficiency 30.6 TIMP2 TIMP1 MMP9 MMP1 ELN
27 williams-beuren syndrome 30.6 MMP9 MMP2 FBN1 ELN CALCA
28 diaphragmatic hernia, congenital 30.5 WT1 GATA4 ELN
29 osteoarthritis 30.5 TIMP1 MMP9 MMP13 MMP1 IL6
30 marfan syndrome 30.4 TIMP2 MMP2 MMP1 LOXL1 FBN1 ELN
31 osteogenic sarcoma 30.4 WT1 MMP9 MMP2 IL6
32 orthostatic intolerance 30.3 FBN1 ELN COL5A1
33 gastrointestinal stromal tumor 30.2 WT1 NF1 MMP9 MMP2
34 ovarian cancer 30.2 WT1 TIMP2 TIMP1 NF1 MMP9 MMP2
35 scoliosis 29.9 TIMP2 TIMP1 NF1 MMP9 MMP13 LOXL1
36 arthrogryposis multiplex with deafness, inguinal hernias, and early death 12.6
37 marfanoid habitus-inguinal hernia-advanced bone age syndrome 12.5
38 lambert syndrome 12.3
39 persistent mullerian duct syndrome 11.9
40 mucopolysaccharidosis, type ii 11.8
41 pseudomyxoma peritonei 11.6
42 exstrophy of bladder 11.6
43 ifap syndrome with or without bresheck syndrome 11.6
44 spondylocostal dysostosis 3, autosomal recessive 11.5
45 aarskog-scott syndrome 11.4
46 opitz-kaveggia syndrome 11.4
47 achondrogenesis, type ib 11.4
48 acrofacial dysostosis, catania type 11.3
49 spondylocostal dysostosis 5 11.3
50 hyperekplexia 1 11.3

Graphical network of the top 20 diseases related to Inguinal Hernia:



Diseases related to Inguinal Hernia
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Symptoms & Phenotypes for Inguinal Hernia

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GenomeRNAi Phenotypes related to Inguinal Hernia according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased sensitivity to paclitaxel GR00112-A-0 8.62 NF1 WT1

MGI Mouse Phenotypes related to Inguinal Hernia:

45 (show all 16)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.43 ADAMTS6 AR COL5A1 EFEMP1 FBLN5 FBN1
2 growth/size/body region MP:0005378 10.41 ADAMTS6 AR COL5A1 EBF2 EFEMP1 FBLN5
3 homeostasis/metabolism MP:0005376 10.38 ADAMTS6 AR EFEMP1 FBLN5 FBN1 GATA4
4 hematopoietic system MP:0005397 10.27 ADAMTS6 AR EFEMP1 FBN1 GATA4 IL6
5 immune system MP:0005387 10.23 ADAMTS6 AR EFEMP1 FBN1 IL6 MMP1
6 endocrine/exocrine gland MP:0005379 10.22 ADAMTS6 AR EBF2 EFEMP1 FBN1 GATA4
7 integument MP:0010771 10.17 AR COL5A1 EFEMP1 FBLN5 FBN1 GATA4
8 digestive/alimentary MP:0005381 10.14 ADAMTS6 AR EFEMP1 GATA4 IL6 LOXL1
9 craniofacial MP:0005382 10.09 ADAMTS6 AR EBF2 FBLN5 FBN1 MMP2
10 muscle MP:0005369 10.07 AR EFEMP1 FBLN5 FBN1 GATA4 IL6
11 limbs/digits/tail MP:0005371 10.06 ADAMTS6 AR EBF2 FBN1 GATA4 MMP13
12 neoplasm MP:0002006 9.97 AR FBLN5 IL6 MMP1 MMP2 MMP9
13 normal MP:0002873 9.91 AR COL5A1 EBF2 EFEMP1 GATA4 MMP2
14 reproductive system MP:0005389 9.9 AR EBF2 EFEMP1 FBN1 GATA4 IL6
15 respiratory system MP:0005388 9.7 EBF2 FBLN5 FBN1 GATA4 IL6 LOXL1
16 skeleton MP:0005390 9.4 ADAMTS6 AR EBF2 EFEMP1 FBN1 GATA4
Sources

Drugs & Therapeutics for Inguinal Hernia

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Drugs for Inguinal Hernia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 181)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Caffeine Approved Phase 4 58-08-2 2519
2
Ethanol Approved Phase 4 64-17-5 702
3
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 5311068 68602
4
Remifentanil Approved Phase 4 132875-61-7 60815
5
Iodine Approved, Investigational Phase 4 7553-56-2 807
6
Povidone Approved Phase 4 9003-39-8
7
Povidone-iodine Approved Phase 4 25655-41-8
8
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 4 7487-88-9 24083
9
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
10
Cefazolin Approved Phase 4 25953-19-9 656510 33255
11
Chloroprocaine Approved Phase 4 133-16-4 8612
12
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
13
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
14
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
15
Procaine Approved, Investigational, Vet_approved Phase 4 59-46-1 4914
16
tannic acid Approved Phase 4 1401-55-4
17
Benzocaine Approved, Investigational Phase 4 94-09-7, 1994-09-7 2337
18
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
19
Prilocaine Approved Phase 4 721-50-6 4906
20
Tizanidine Approved, Investigational Phase 4 51322-75-9 5487
21
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
22
Montelukast Approved Phase 4 158966-92-8 5281040
23
Naproxen Approved, Vet_approved Phase 4 22204-53-1 1302 156391
24
Atenolol Approved Phase 4 29122-68-7 2249
25
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
26
Clonidine Approved Phase 4 4205-90-7 2803
27
Ibuprofen Approved Phase 4 15687-27-1 3672
28
Acetaminophen Approved Phase 4 103-90-2 1983
29
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
30
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
31
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
32
Ketorolac Approved Phase 4 66635-83-4, 74103-06-3 3826
33
Tamsulosin Approved, Investigational Phase 4 106133-20-4 129211
34
Glutamic acid Approved, Nutraceutical Phase 4 56-86-0 33032
35
Cysteine Approved, Nutraceutical Phase 4 52-90-4 5862
36
Imidacloprid Vet_approved Phase 4 105827-78-9 86418
37 Phosphodiesterase Inhibitors Phase 4
38 Central Nervous System Stimulants Phase 4
39 calcium channel blockers Phase 4
40 Platelet Aggregation Inhibitors Phase 4
41 Anesthetics, Inhalation Phase 4
42 Adrenergic alpha-Agonists Phase 4
43 Adrenergic Agonists Phase 4
44 Neuromuscular Blocking Agents Phase 4
45 cadexomer iodine Phase 4
46 Tocolytic Agents Phase 4
47 Anti-Bacterial Agents Phase 4
48 Antibiotics, Antitubercular Phase 4
49 Anesthetics Phase 4
50 Anesthetics, Local Phase 4

Interventional clinical trials:

(show top 50) (show all 435)
# Name Status NCT ID Phase Drugs
1 Early Outcome of Inguinal Hernia Repair With Biomerix Surgical Mesh Using the Lichtenstein Technique Unknown status NCT00924755 Phase 4
2 Does Ultrasound-guided Ilioinguinal-iliohypogastric Block Improve Postoperative Pain Outcome After Unilateral Inguinal Hernia Repair? Unknown status NCT01326039 Phase 4 bupivacaine;saline
3 Rebound Hernia Repair Device Trial Unknown status NCT00968773 Phase 4
4 Controlled Release of Oxycodone 10 mg In Pre-Medication For The Post Operative Analgesia In Elective Laparoscopic Bilateral Inguinal Hernia And Elective Laparoscopic Cholecystectomy : Prospective Double Blind, Randomized, Placebo-Controlled Study Unknown status NCT00480142 Phase 4 Oxycodone 10 mg
5 The Effect of Different Doses of Ketamine on Tracheal Intubating Conditions Using Low Dose Rocuronium in Children Unknown status NCT02646709 Phase 4 Rocuronium;ketamine 1;ketamine 1.5;ketamine 2
6 Investigating the Effect of Intra-operative Infiltration With Local Anaesthesia on the Development of Chronic Postoperative Pain After Inguinal Hernia Repair. A Randomized Placebo Controlled Triple Blinded and Group Sequential Study Design Unknown status NCT00484731 Phase 4
7 The Impact of Perioperative Gabapentin on Chronic Groin Pain After Inguinal Hernia Repair Unknown status NCT02419443 Phase 4 Gabapentin;Placebo
8 Effects of Transverse Abdominis Plane Block Guided by Ultrasound on the Postoperative Analgesia and Quality of Lives Among the Patients Undergo Inguinal Hernia Repair Unknown status NCT02292095 Phase 4
9 Multicentre Randomised Controled Trial Comparing the Effect of a New Self-gripping Lightweight Polyester Mesh and a Normal Sutured Lightweight Polyester Mesh on the Incidence of Chronic Inguinodynia in Lichtenstein Hernioplasty. Unknown status NCT01830452 Phase 4
10 Chronic Significant Pain and Functional Outcome After Laparoscopic Versus Open Groin Hernia Mesh Repair: Design of a Randomized Controlled Clinical Trial Unknown status NCT00625534 Phase 4
11 Influence of Anesthetic Technique on Acute and Chronic Neuropathic Pain Unknown status NCT02527083 Phase 4 Propofol;Sevoflurane;Remifentanil;Ketamine
12 Ultrasound-guided Transverses Abdominis Plane Block in Inguinal Herniorrhaphy: Randomized Controlled Clinical Trial Unknown status NCT02299908 Phase 4 TAP block with Bupivacaine at 0.25%;Placebo saline solution
13 Comparative Study of a Iodine + Cyanoacrylate (Integuseal) vs. Iodine and Isopropyl Alcohol in Skin Preparation for Prevention of Surgical Site Infections in Oncologic Surgery Unknown status NCT01110772 Phase 4
14 Remifentanil-dexmedetomidine Anesthesia as an Alternative Anesthetic for Elective Pediatric Surgery: a Pilot Study. Unknown status NCT02799589 Phase 4 Remifentanil;Dexmedetomidine;Ropivacaine
15 Abdominal Midline Incisional Hernia Repair and Functional Outcome: Randomized Controlled Trial to Compare Open and Laparoscopic Surgical Unknown status NCT00625053 Phase 4
16 Intravenous Versus Caudal Magnesium Sulfate as an Adjuvant to Caudal Bupivacaine in Lower Abdominal Surgeries in Paediatrics Under General Anaesthesia Unknown status NCT03322878 Phase 4 Magnesium SO4
17 Prospective, Randomized, Controlled, Third-Party Blinded Multicenter Evaluation of Strattice/LTM in the Repair of Inguinal Hernias Completed NCT00681291 Phase 4
18 Single Dose Antibiotic Prophylaxis in Lihtenstein Repair for Primary Inguinal Hernias Completed NCT01264003 Phase 4 sefazolin
19 Prolene Hernia System, Lichtenstein Mesh, and Plug-and-Patch for Primary Inguinal Hernia Repair - Three Year Outcome of a Prospective Randomised Controlled Trial Completed NCT00580177 Phase 4
20 ProGrip Mesh Repair Versus Lichtenstein Mesh Repair: a Comparative Randomized Study in Primary Inguinal Hernia Completed NCT00827944 Phase 4
21 Comparative Study of Safety and Efficacy of Heavyweight and Partially Absorbable Mesh in Inguinal Hernia Repair Completed NCT01877122 Phase 4
22 Comparision of the Use in Marcaine and Chloroprocaine in Rachianesthesia for the Surgical Correction of Inguinal Hernia. Completed NCT02049255 Phase 4 Chloroprocaine;Marcaine
23 Comparing Non-fixation of Mesh to Mesh Fixation in Laparoscopic Total Extraperitoneal Inguinal Hernia Repair Under Spinal Anesthesia- A Randomized Controlled Trial Completed NCT01117337 Phase 4
24 A Multicenter Prospective Randomized Trial on Chronic Pain After Inguinal Hernia Repair Using a Selfgrip-mesh Completed NCT00820131 Phase 4
25 Lichtenstein's Repair of Inguinal Hernia With Polypropylene Mesh Versus Infinit® PTFE Mesh, a Prospective Randomized, Double-blind, Controlled Trial Completed NCT01141335 Phase 4
26 Analgesic Efficacy of Ultrasound-guided Inguinal Field Block (Genitofemoral, Iliohypogastric and Ilioinguinal Nerve Block) for Inguinal Hernia Surgery. Completed NCT01521481 Phase 4
27 The Comparison of Two Different Doses of Morphine Added to Spinal Bupivacaine for Inguinal Hernia Repair. Completed NCT02001948 Phase 4 intrathecal morphine 0.1 mg combined with intrathecal heavy bupivacaine 7.5 mg;intrathecal morphine 0.4 mg combined with intrathecal heavy bupivacaine 7.5 mg;intravenous cannulation and premedication
28 Prospective, Controlled, Randomized Study to Evaluate Pain and Further Disabling Complications in Patients Undergoing Lichtenstein Technique for Primary Inguinal Hernia Repair by Fixing the Mesh With Fibrin Sealant Versus Sutures Completed NCT00306839 Phase 4
29 Evaluation of Postoperative Pain Following Laparoscopic Hernia Repair: A Prospective, Randomized Comparison to Evaluate the Incidence of Post-operative Pain Associated With Absorbable Fixation (AbsorbaTack) vs Conventional Fixation (ProTack) Following Laparoscopic Hernia Repair Completed NCT00749268 Phase 4
30 Is Topical Antibiotic Prophylaxis Effective in Lichtenstein Hernia Repair: a Comparison Study Completed NCT01273818 Phase 4 Gentamicin and cefazolin;Cefazolin;Gentamicin
31 Evaluation of Dexamethasone Added to the Usual Infiltration With Bupivacaine in Inguinal Hernia Repair Mesh Completed NCT03007927 Phase 4 Bupivacaine-Dexamethasone;Bupivacaine- physiological solution
32 Comparison of Postoperative Analgesic Effects of Transversus Abdominis Plane Block and Quadratus Lumborum Block Type 2 Completed NCT03126084 Phase 4 Acetaminophen;0.25% Bupivacaine;0.5% Bupivacaine+Glucose;Tramadol HCl;0.25% Bupivacaine
33 Preoperative Administration of Tamsulosin for Prevention of Post Operative Urinary Retention in Males Undergoing Elective Inguinal Hernia Repair Completed NCT02958878 Phase 4 Tamsulosin;Placebo Oral Capsule
34 A Multi-site Randomised Controlled Trial Comparing Regional and General Anaesthesia for Effects on Neurodevelopmental Outcome and Apnoea in Infants Completed NCT00756600 Phase 4 Regional Anesthesia;General Anesthesia
35 Selective Subarachnoid Anesthesia. Comparison of Hyperbaric Bupivacaine and Hyperbaric Prilocaine in Knee Arthroscopy and Inguinal Hernia Repair in Ambulatory Surgery Completed NCT01921231 Phase 4 Hyperbaric Prilocaine 1%;Hyperbaric bupivacaine 0.5%
36 Comparative Efficacy of Intravenous Acetaminophen vs. Oral Acetaminophen in Ambulatory Surgery Completed NCT03558555 Phase 4 Acetaminophen IV Soln;Oral Acetaminophen;Placebo Pills;Saline
37 Early and Late Results of Transinguinal Preperitoneal Patch Repair Versus Anterior Pre-Trasversalis Mesh Repair. A Randomised Study Completed NCT01350830 Phase 4
38 Prospective Randomized, Double-Blind, Controlled Trial Comparing Lichtenstein's Repair of Inguinal Hernia With Polypropylene Mesh Versus Surgisis ES Soft Tissue Graft Completed NCT00614419 Phase 4
39 THE EFFECT OF DIFFERENT INDUCTION TECHNIQUES ON POSTOPERATIVE PAIN AND AGITATION IN CHILDREN Completed NCT02110745 Phase 4 Sevofluorane;Propofol
40 Investigation of the Effectiveness of Tizanidine on Pain After Herniorrhaphy Completed NCT02016443 Phase 4 Tizanidine;Placebo
41 The Efficacy of Transversus Abdominis Plane Block Versus Placebo Versus Local Infiltration in Patients Undergoing Groin Hernia Repair in Day Case Surgery. Completed NCT01052285 Phase 4
42 A Comparison of the Recovery Profiles of Bupivacaine or Bupivacaine Mixed With Lidocaine Spinal Anesthesia and Local Infiltration Anesthesia for Outpatient Herniorrhaphy Completed NCT01548794 Phase 4
43 Evaluation of the Analgesic Effect of Tramadol Wound Infiltration in Children Under Inguinal Hernioplasty. A Double-blind, Randomized Study. Completed NCT01943760 Phase 4 tramadol;0.9% saline
44 ZIH Study : Comparison of Oral Zaldiar (Combination of Paracetamol and Tramadol) With Intravenous Paracetamol and Tramadol for Postoperative Analgesia After Inguinal Hernia Repair Completed NCT02389361 Phase 4 Zaldiar;Paracetamol-Tramadol
45 Ultrasound-guided Rectus Sheath Block In Children Completed NCT02291705 Phase 4 Tramadol
46 A Randomized, Phase 4 Study of the Efficacy, Safety, and Pharmacokinetics of Bupivacaine Administered as Liposomal Bupivacaine or Continuous Infusion Via Elastomeric Pump Following Unilateral Open Inguinal Herniorrhaphy Completed NCT04102267 Phase 4 Bupivacaine liposome injectable suspension;Bupivacaine HCl without epinephrine via continuous infusion
47 Comparison Of The Analgesia Obtained By Infiltration Of Lidocaïne 1% And Ropivacaïne 0,75% Versus Placebo For The Joinings Of Episiotomies Among Parturients Under Epidural Analgesia Completed NCT00727935 Phase 4 Lidocaïne;Ropivacaïne;Placebo
48 The Effects on Airway Reactivity of the Use of Preoperative Montelukast Sodium Completed NCT02494466 Phase 4 montelukast sodium
49 Controlled-Release Oxycodone Versus Naproxen at Home After Ambulatory Surgery: A Randomized Controlled Trial Completed NCT02152592 Phase 4 PCM/Oxy1;PCM/Oxy2
50 Determination of the Minimum Local Anesthetic Dose (MLAD) of Spinal Chloroprocaine for Inguinal Herniorrhaphy in Ambulatory Surgery Completed NCT03805503 Phase 4 Chloroprocaine 1% Injectable Solution

Search NIH Clinical Center for Inguinal Hernia

Cochrane evidence based reviews: hernia, inguinal

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Genetic Tests for Inguinal Hernia

About this section

Genetic tests related to Inguinal Hernia:

# Genetic test Affiliating Genes
1 Inguinal Hernia 29
Sources

Anatomical Context for Inguinal Hernia

About this section

MalaCards organs/tissues related to Inguinal Hernia:

40
Testis, Colon, Skin, Appendix, Uterus, Prostate, Ovary
Sources

Publications for Inguinal Hernia

About this section

Articles related to Inguinal Hernia:

(show top 50) (show all 11611)
# Title Authors PMID Year
1
Preoperative oral granisetron for the prevention of vomiting following paediatric surgery. 61 54
11903942 2002
2
A role for the collagen I/III and MMP-1/-13 genes in primary inguinal hernia? 61 54
11872152 2002
3
Prophylactic therapy with combined granisetron and dexamethasone for the prevention of post-operative vomiting in children. 61 54
10434165 1999
4
Synthesis of type I and III collagen, expression of fibronectin and matrix metalloproteinases-1 and -13 in hernial sac of patients with inguinal hernia. 54 61
11341610 1999
5
Granisetron reduces post-operative vomiting in children: a dose-ranging study. 61 54
10084103 1999
6
Senior General Surgery Resident Confidence in Performing Abdominal Wall Hernia Repairs. 61
32278972 2020
7
The effect of dexmedetomidine on spinal anesthesia quality and hemodynamic changes in patients undergoing inguinal hernia repair surgery: intravenous versus intrathecal. 61
32318749 2020
8
Patient-Reported Outcomes and Long-Term Results of a Randomized Controlled Trial Comparing Single-Port Versus Conventional Laparoscopic Inguinal Hernia Repair. 61
32123978 2020
9
The transversus abdominis plane block may reduce chronic postoperative pain one year after TAPP ingunial hernia repair. 61
32518639 2020
10
Gilbert double layer graft method for groin hernias in patients with ascites: A retrospective study of 81 patients. 61
32362435 2020
11
Robotic Approach to Outpatient Inguinal Hernia Repair. 61
32380165 2020
12
Evaluating effectiveness of cognitive behavioral therapy within multimodal treatment for chronic groin pain after inguinal hernia repair. 61
31463721 2020
13
One Step at a Time: Step by Step Versus Continuous Video-Based Learning to Prepare Medical Students for Performing Surgical Procedures. 61
32171749 2020
14
Comparative study of collagen and elastin content of abdominal wall fascia in inguinal hernia and non-hernia patients in an African population. 61
32488528 2020
15
Invited commentary on "Diathermy versus scalpel for skin incision in patients undergoing open inguinal hernia repair: A systematic review and meta-analysis". 61
32311517 2020
16
An invited commentary on "neo-nervegenesis in 3D dynamic responsive implant for inguinal hernia repair. Qualitative study. Int J Surg 2020;76:114-119″. 61
32360504 2020
17
Comparison of a 3D head-mounted display (HMS-3000MT) and 3D passive polarizing display with 2D technique for first laparoscopic inguinal hernia repair by novice surgeons. 61
31745653 2020
18
Fixation versus no fixation in laparoscopic totally extraperitoneal repair of primary inguinal hernia-a systematic review and meta-analysis of randomized controlled trials. 61
32533360 2020
19
A prospective randomized comparison of sexual function and semen analysis following laparoscopic totally extraperitoneal (TEP) and transabdominal pre-peritoneal (TAPP) inguinal hernia repair. 61
32556764 2020
20
Synergistic effect of local dexamethasone and dexmedetomidine (Dex-Dex) in extending the analgesic effect of a transversus abdominis plane block prior to inguinal hernia repair. 61
32018130 2020
21
Correction to: A prospective randomised control trial to compare the perioperative outcomes and ergonomic challenges between triangular versus midline port placement in total extra-peritoneal repair of uncomplicated inguinal hernia. 61
32529353 2020
22
Correction to: The transversus abdominis plane block reduces the cumulative need of analgesic medication following inguinal hernia repair in TAPP technique: a retrospective single center analysis among 838 patients. 61
32519197 2020
23
Using Point-of-Care Ultrasound to Characterize Acute Inguinal Swelling of Young Children in the Pediatric Emergency Department. 61
32011551 2020
24
A case of indirect inguinal bladder hernia treated by laparoscopic hernia repair. 61
32500655 2020
25
Ectopic adrenal tissue in a hernia sac in an adult. A case report. 61
32519677 2020
26
A three-arm randomized study to compare sexual functions and fertility indices following open mesh hernioplasty (OMH), laparoscopic totally extra peritoneal (TEP) and transabdominal preperitoneal (TAPP) repair of groin hernia. 61
32556769 2020
27
Metabolic and Inflammatory Benefits of Reducing Preoperative Fasting Time in Pediatric Surgery. 61
32578813 2020
28
General Anesthesia Maintained with Sevoflurane versus Propofol in Pediatric Surgery Shorter Than 1 Hour: A Randomized Single-Blind Study. 61
32572017 2020
29
Presurgical risk model for chronic postsurgical pain based on six clinical predictors: a prospective external validation. 61
32541391 2020
30
Human cremaster muscle and cremasteric reflex: A comprehensive review. 61
32305856 2020
31
Use of commercial mesh for hernia repair in a low resource setting: experience after 500 cases. 61
31129796 2020
32
Emergent groin hernia repair at a County Hospital in Guatemala: patient-related issues vs. health care system limitations. 61
31429024 2020
33
Single-port laparoscopic percutaneous extraperitoneal closure for inguinal hernias repair in girls: using an epidural needle assisted by a towel forceps. 61
32560649 2020
34
Is round ligament varicosity in pregnancy a common precursor for the later development of inguinal hernias? The prospective analysis of 28 patients over 9 years. 61
30900041 2020
35
[Bladder hernia: report of a case series and review of the literature]. 61
32557520 2020
36
Sonographic "speech bubble/speech box sign" in clinically occult femoral hernias: ultrasound findings and anatomical basis. 61
32504328 2020
37
Laparoscopic total extraperitoneal (TEP) mesh repair for femoral hernia in a patient of child B liver cirrhosis with ascites. A case report. 61
32563089 2020
38
Robotic assisted eTEP ventral hernia repair: Brazilian early experience. 61
32495056 2020
39
Autologous bionic tissue for inguinal hernia repair. 61
32090432 2020
40
The "Best" Inguinal Hernia Repair Technique. 61
32524160 2020
41
Inguinal Hernia in Premature Infants. 61
32482701 2020
42
Consent Including Sexual Dysfunction and Pain with Sexual Activity after Inguinal Hernia Repair? 61
32173251 2020
43
Laparoscopic Transabdominal Preperitoneal (TAPP) Inguinal Hernia Repair Using Fibrin Glue for Fixation of the Mesh and Peritoneum Closure. 61
32487858 2020
44
Influence of previous laparo-endoscopic inguinal hernia repair on performing radical prostatectomy: a nationwide survey among urological surgeons. 61
32488655 2020
45
Comparison of types 2 and 3 quadratus lumborum muscle blocks : Open inguinal hernia surgery in patients with spinal anesthesia. 61
32303784 2020
46
A 9-year experience study of single-port micro-laparoscopic repair of pediatric inguinal hernia using a simple needle. 61
31893317 2020
47
Safety and effectiveness of inguinal hernia repair in patients with liver cirrhosis: a retrospective study and literature review. 61
31773547 2020
48
The safety and feasibility of tumescent local anesthesia for inguinal hernia repair: A review of 273 consecutive patients. 61
32033886 2020
49
Total extraperitoneal laparoscopic inguinal hernia repair with adductor tenotomy: a 10-year experience in the treatment of athletic pubalgia. 61
32556756 2020
50
Do drains have an impact on the outcome after primary elective unilateral inguinal hernia repair in men? 61
32566993 2020
Sources

Variations for Inguinal Hernia

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ClinVar genetic disease variations for Inguinal Hernia:

6 (show all 14) ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 subset of 29 genes: TBX1 GRCh37/hg19 22q11.21(chr22:18894835-20311763)copy number loss Pathogenic 523273 22:18894835-20311763
2 EFEMP1 NM_001039348.3(EFEMP1):c.615T>A (p.Tyr205Ter)SNV Pathogenic 691885 2:56108772-56108772 2:55881637-55881637
3 EFEMP1 NM_001039348.3(EFEMP1):c.320_324del (p.Met107fs)deletion Pathogenic 691884 2:56144993-56144997 2:55917858-55917862
4 NF1 NM_000267.3(NF1):c.7419G>A (p.Trp2473Ter)SNV Pathogenic 216067 rs863224493 17:29679299-29679299 17:31352281-31352281
5 46;XY;t(1;5)(p35.3;q31.3)dnTranslocation Pathogenic 267817
6 46;XY;t(3;10)(p26.3;q26.3)dnTranslocation Pathogenic 267848
7 46;XY;inv(6)(p22q13)dninversion Pathogenic 267941
8 FBN1 NM_000138.4(FBN1):c.840_843del (p.Asn280fs)deletion Pathogenic 374115 rs1057518909 15:48826296-48826299 15:48534099-48534102
9 ACTL6A NM_004301.5(ACTL6A):c.1129C>T (p.Arg377Trp)SNV Likely pathogenic 549661 rs868064163 3:179304340-179304340 3:179586552-179586552
10 COL5A1 NM_001278074.1(COL5A1):c.608G>T (p.Gly203Val)SNV Likely pathogenic 523328 rs1554781700 9:137593133-137593133 9:134701287-134701287
11 ELN NM_000501.4(ELN):c.898A>T (p.Thr300Ser)SNV Uncertain significance 523433 rs766735416 7:73466262-73466262 7:74051932-74051932
12 LSM1 NM_014462.3(LSM1):c.231+4A>CSNV Uncertain significance 623485 rs775468919 8:38027316-38027316 8:38169798-38169798
13 46;XY;t(4;14)(p15.32;q32.1)dnTranslocation Uncertain significance 267808
14 46;XY;t(1;3)(p22;q21)dnTranslocation Uncertain significance 267862
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Expression for Inguinal Hernia

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Search GEO for disease gene expression data for Inguinal Hernia.
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Pathways for Inguinal Hernia

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Pathways related to Inguinal Hernia according to GeneCards Suite gene sharing:

(show all 25)
# Super pathways Score Top Affiliating Genes
1
Integrin Pathway 63
Show member pathways
 13.29 MMP9 MMP2 MMP13 MMP1 FBN1 ELN
2
Phospholipase-C Pathway 63
Show member pathways
 12.96 TIMP2 TIMP1 IL6 FBN1 ELN EFEMP1
3
Collagen chain trimerization 65
Show member pathways
 12.75 MMP9 MMP13 LOXL1 ELN COL5A1
4
Pathways in cancer 36
12.74 MMP9 MMP2 MMP1 IL6 AR
5
IL-17 Family Signaling Pathways 64
Show member pathways
 12.23 MMP9 MMP13 MMP1 IL6
6
Colorectal Cancer Metastasis 63
12.09 MMP9 MMP2 MMP1 IL6
7
Degradation of the extracellular matrix 65
Show member pathways
 12.05 TIMP2 TIMP1 MMP9 MMP2 MMP13 MMP1
8
Interleukin-4 and 13 signaling 65
11.89 TIMP1 MMP9 MMP2 MMP1 IL6
9
Matrix Metalloproteinases 1
Show member pathways
 11.73 TIMP2 TIMP1 MMP9 MMP2 MMP13 MMP1
10
Angiogenesis (CST) 4
11.72 TIMP2 TIMP1 MMP9 MMP2 MMP13
11
Regulation of Wnt-mediated beta catenin signaling and target gene transcription 1
11.68 MMP9 MMP2 AR
12
Bladder cancer 36 1
11.64 MMP9 MMP2 MMP1
13
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.6 MMP9 MMP2 MMP1 IL6
14
AGE/RAGE pathway 1
11.59 MMP9 MMP2 MMP13
15
Elastic fibre formation 65
Show member pathways
 11.58 LOXL1 FBN1 FBLN5 ELN EFEMP1
16
LPA receptor mediated events 1
11.57 MMP9 MMP2 IL6
17
ATF-2 transcription factor network 1
11.49 NF1 MMP2 IL6
18
Lung fibrosis 1
11.43 TIMP1 MMP9 MMP2 IL6 ELN CALCA
19
amb2 Integrin signaling 1
11.42 MMP9 MMP2 IL6
20
Transcription_Role of VDR in regulation of genes involved in osteoporosis 22
11.37 IL6 CALCA AR
21
Cell adhesion_Cell-matrix glycoconjugates 22
11.35 TIMP2 MMP9 MMP1 ELN
22
Validated transcriptional targets of AP1 family members Fra1 and Fra2 1
11.24 MMP9 MMP2 MMP1 IL6
23
Cell adhesion_ECM remodeling 22
11.22 TIMP2 TIMP1 MMP9 MMP2 MMP13 MMP1
24
IL1 and megakaryocytes in obesity 1
11.08 TIMP2 TIMP1 MMP9
25
G-protein signaling_Rap2B regulation pathway 22
10.92 TIMP2 TIMP1 IL6 FBN1 ELN EFEMP1
Sources

GO Terms for Inguinal Hernia

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Cellular components related to Inguinal Hernia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 10.03 TIMP2 TIMP1 MMP9 MMP2 MMP13 LOXL1
2 extracellular region GO:0005576 10.03 TIMP2 TIMP1 MMP9 MMP2 MMP13 MMP1
3 basement membrane GO:0005604 9.62 TIMP1 LOXL1 FBN1 COL5A1
4 collagen-containing extracellular matrix GO:0062023 9.61 TIMP2 MMP9 MMP2 LOXL1 FBN1 FBLN5
5 collagen trimer GO:0005581 9.58 TIMP1 MMP13 COL5A1
6 extracellular matrix GO:0031012 9.44 TIMP2 TIMP1 MMP9 MMP2 MMP13 MMP1
7 elastic fiber GO:0071953 9.37 FBLN5 ELN

Biological processes related to Inguinal Hernia according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.93 WT1 TIMP2 NF1 IL6 AR
2 heart development GO:0007507 9.88 WT1 NF1 FBN1 ADAMTS6
3 cytokine-mediated signaling pathway GO:0019221 9.8 TIMP1 MMP9 MMP2 MMP1 IL6
4 cellular protein metabolic process GO:0044267 9.7 TIMP1 MMP2 MMP13 MMP1 IL6 FBN1
5 camera-type eye development GO:0043010 9.67 WT1 FBN1 EFEMP1
6 collagen fibril organization GO:0030199 9.65 NF1 LOXL1 COL5A1
7 embryo implantation GO:0007566 9.63 MMP9 MMP2 CALCA
8 regulation of neuroinflammatory response GO:0150077 9.57 MMP9 IL6
9 embryonic eye morphogenesis GO:0048048 9.56 FBN1 EFEMP1
10 collagen catabolic process GO:0030574 9.56 MMP9 MMP2 MMP13 MMP1
11 positive regulation of adenylate cyclase activity GO:0045762 9.55 TIMP2 NF1
12 negative regulation of osteoclast differentiation GO:0045671 9.54 NF1 FBN1 CALCA
13 negative regulation of metallopeptidase activity GO:1905049 9.52 TIMP2 TIMP1
14 negative regulation of membrane protein ectodomain proteolysis GO:0051045 9.51 TIMP2 TIMP1
15 response to amyloid-beta GO:1904645 9.5 MMP9 MMP2 MMP13
16 post-embryonic eye morphogenesis GO:0048050 9.43 FBN1 EFEMP1
17 extracellular matrix disassembly GO:0022617 9.43 TIMP2 TIMP1 MMP9 MMP2 MMP13 MMP1
18 extracellular matrix organization GO:0030198 9.36 NF1 MMP9 MMP2 MMP13 MMP1 LOXL1

Molecular functions related to Inguinal Hernia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 metal ion binding GO:0046872 10.13 WT1 TIMP2 TIMP1 MMP9 MMP2 MMP13
2 peptidase activity GO:0008233 9.85 MMP9 MMP2 MMP13 MMP1 ADAMTS6
3 integrin binding GO:0005178 9.73 TIMP2 FBN1 FBLN5 COL5A1
4 extracellular matrix structural constituent GO:0005201 9.71 FBN1 ELN EFEMP1 COL5A1
5 endopeptidase activity GO:0004175 9.67 MMP9 MMP2 MMP13 MMP1
6 metallopeptidase activity GO:0008237 9.65 MMP9 MMP2 MMP13 MMP1 ADAMTS6
7 metalloendopeptidase activity GO:0004222 9.35 MMP9 MMP2 MMP13 MMP1 ADAMTS6
8 extracellular matrix constituent conferring elasticity GO:0030023 9.33 FBN1 FBLN5 ELN
9 zinc ion binding GO:0008270 9.28 WT1 TIMP2 TIMP1 MMP9 MMP2 MMP13
Sources

Sources for Inguinal Hernia

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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