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MCID: ING001
MIFTS: 57

Inguinal Hernia

Categories: Gastrointestinal diseases
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Aliases & Classifications for Inguinal Hernia

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MalaCards integrated aliases for Inguinal Hernia:

Name: Inguinal Hernia 11 75 28 5 14 31 33
Indirect Inguinal Hernia 33
Oblique Inguinal Hernia 33
Direct Inguinal Hernia 33
Ih - [inguinal Hernia] 33
Hernia, Inguinal 43
Inguinal Hernias 14
Hernia Inguinal 53
Scrotal Hernia 33
Bubonocele 33

Classifications:

MalaCards categories:
Anatomical: Gastrointestinal diseases
See all MalaCards categories (disease lists)
ICD10: 31
ICD11: 33


External Ids:

Disease Ontology 11 DOID:0060320
ICD9CM 34 550
MeSH 43 D006552
SNOMED-CT 68 155738001 196800008
ICD11 33 474718032
UMLS 71 C0019294 C0019295 C0019296
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Summaries for Inguinal Hernia

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Disease Ontology: 11 An intestinal disease characterized by a protrusion of abdominal cavity contests through the inguinal canal.

MalaCards based summary: Inguinal Hernia, also known as indirect inguinal hernia, is related to persistent mullerian duct syndrome and cutis laxa, autosomal recessive, type ia. An important gene associated with Inguinal Hernia is FBN1 (Fibrillin 1), and among its related pathways/superpathways are Integrin Pathway and Phospholipase-C Pathway. The drugs Rocuronium and Ketamine have been mentioned in the context of this disorder. Affiliated tissues include colon, liver and testis, and related phenotypes are homeostasis/metabolism and growth/size/body region

Wikipedia: 75 An inguinal hernia is a hernia (protrusion) of abdominal-cavity contents through the inguinal canal.... more...
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Related Diseases for Inguinal Hernia

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Diseases related to Inguinal Hernia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 734)
# Related Disease Score Top Affiliating Genes
1 persistent mullerian duct syndrome 32.6 INSL3 HSD17B3 GATA4 AMHR2 AMH
2 cutis laxa, autosomal recessive, type ia 32.5 FBLN5 ELN EFEMP2 EFEMP1
3 arterial tortuosity syndrome 32.3 FBN1 FBLN5 ELN EFEMP2 COL5A1
4 cutis laxa, autosomal recessive, type iia 32.2 FBLN5 EFEMP2
5 cutis laxa 32.2 MMP1 LTBP1 FBN1 FBLN5 ELN EFEMP2
6 aortic aneurysm, familial thoracic 1 32.0 MMP1 LTBP1 GATA4 FBN1 FBLN5 ELN
7 cryptorchidism, unilateral or bilateral 31.8 INSL3 HSD17B3 GATA4 AR AMHR2 AMH
8 androgen insensitivity syndrome 31.5 INSL3 HSD17B3 AR AMH
9 aortic aneurysm, familial abdominal, 1 31.4 MMP13 MMP1 FBN1 ELN EFEMP2 CRP
10 aortic aneurysm 31.4 MMP13 MMP1 FBN1 FBLN5 ELN EFEMP2
11 testicular torsion 31.3 INSL3 CRP AMH
12 varicose veins 31.3 MMP1 FBN1 ELN
13 complete androgen insensitivity syndrome 31.3 INSL3 HSD17B3 AR AMH
14 bladder diverticulum 31.3 FBLN5 ELN EFEMP2 EFEMP1
15 persistent mullerian duct syndrome, types i and ii 31.2 AMHR2 AMH
16 pneumothorax 31.2 MMP1 FBN1 FBLN5 ELN CRP COL5A1
17 pseudohermaphroditism 31.2 INSL3 HSD17B3 AR AMHR2 AMH
18 connective tissue disease 31.1 NF1 MMP13 MMP1 FBN1 FBLN5 ELN
19 hypospadias 31.0 INSL3 HSD17B3 GATA4 AR
20 hypermobile ehlers-danlos syndrome 30.9 FBN1 EFEMP1 COL5A1
21 collagen disease 30.8 FBN1 ELN CRP COL5A1
22 testicular disease 30.8 INSL3 AR AMHR2 AMH
23 mullerian duct aplasia, unilateral renal agenesis, and cervicothoracic somite anomalies 30.8 AMHR2 AMH
24 testicular germ cell cancer 30.7 INSL3 AR AMH
25 atrial heart septal defect 30.6 GATA4 FBN1 ELN CRP ACTL6A
26 diaphragmatic hernia, congenital 30.6 GATA4 FBN1 ELN EFEMP2 CRP
27 ehlers-danlos syndrome 30.6 FBN1 FBLN5 ELN EFEMP2 COL5A1 ADAMTS6
28 hypogonadotropic hypogonadism 30.6 INSL3 HSD17B3 AR AMHR2 AMH
29 brittle bone disorder 30.5 MMP13 FBN1 ELN COL5A1
30 hypermobility syndrome 30.5 FBN1 COL5A1
31 pelvic organ prolapse 30.5 MMP1 FBLN5 ELN
32 exfoliation syndrome 30.5 MMP1 FBN1 ELN
33 aortic valve disease 2 30.4 GATA4 FBN1 ELN CRP
34 aortic disease 30.4 FBN1 ELN EFEMP2 CRP
35 heart valve disease 30.4 FBN1 ELN CRP
36 patent ductus arteriosus 1 30.4 GATA4 FBN1 ELN EFEMP2 CRP
37 orthostatic intolerance 30.4 FBN1 ELN EFEMP2 CRP COL5A1
38 turner syndrome 30.4 NF1 AR AMH
39 osteochondrodysplasia 30.4 NF1 MMP13 FBN1 ELN COL5A1
40 williams-beuren syndrome 30.4 GATA4 FBN1 FBLN5 ELN EFEMP2
41 scoliosis 30.4 NF1 MMP13 FBN1 FBLN5 ELN EFEMP1
42 synovitis 30.4 MMP13 MMP1 CRP
43 disorder of sexual development 30.3 INSL3 HSD17B3 GATA4 AR AMHR2 AMH
44 elephantiasis 30.3 NF1 ELN
45 marfan syndrome 30.3 MMP1 FBN1 ELN
46 enterocele 11.8
47 marfanoid habitus-inguinal hernia-advanced bone age syndrome 11.5
48 lambert syndrome 11.4
49 arthrogryposis multiplex with deafness, inguinal hernias, and early death 11.4
50 collins pope syndrome 11.3

Graphical network of the top 20 diseases related to Inguinal Hernia:



Diseases related to Inguinal Hernia
Sources

Symptoms & Phenotypes for Inguinal Hernia

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GenomeRNAi Phenotypes related to Inguinal Hernia according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 10.18 ACTL6A ADAMTS6 AMH AMHR2 AR CEMIP2
2 no effect GR00402-S-2 10.18 ACTL6A ADAMTS6 AMH AMHR2 AR CEMIP2

MGI Mouse Phenotypes related to Inguinal Hernia:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.24 ADAMTS6 AMH AMHR2 AR CRP EFEMP1
2 growth/size/body region MP:0005378 10.17 ADAMTS6 AMH AMHR2 AR COL5A1 EFEMP1
3 muscle MP:0005369 10.13 AR EFEMP1 EFEMP2 ELN FBLN5 FBN1
4 renal/urinary system MP:0005367 10.06 ADAMTS6 AMHR2 AR EFEMP1 FBN1 HSD17B3
5 limbs/digits/tail MP:0005371 10.01 ADAMTS6 AR EFEMP2 FBN1 GATA4 LTBP1
6 cardiovascular system MP:0005385 10 ADAMTS6 AMHR2 AR COL5A1 CRP EFEMP1
7 endocrine/exocrine gland MP:0005379 9.96 ADAMTS6 AMH AMHR2 AR EFEMP1 FBN1
8 skeleton MP:0005390 9.7 ADAMTS6 AR EFEMP1 EFEMP2 ELN FBN1
9 integument MP:0010771 9.36 AMHR2 AR COL5A1 EFEMP1 EFEMP2 FBLN5
Sources

Drugs & Therapeutics for Inguinal Hernia

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Drugs for Inguinal Hernia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 161)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
2
Ketamine Approved, Vet_approved Phase 4 6740-88-1, 1867-66-9 3821
3
Caffeine Approved Phase 4 58-08-2 2519
4
Ibuprofen Approved Phase 4 15687-27-1 3672
5
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
6
Tramadol Approved, Investigational Phase 4 27203-92-5 33741 5523
7
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
8
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
9
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
10
Prilocaine Approved Phase 4 721-50-6 4906
11
Acetaminophen Approved Phase 4 103-90-2 1983
12
Benzocaine Approved, Investigational Phase 4 1994-09-7, 94-09-7 2337
13
Tannic acid Approved Phase 4 1401-55-4 16129878 16129778
14
Tizanidine Approved, Investigational Phase 4 51322-75-9 5487
15
Cefazolin Approved Phase 4 25953-19-9 33255
16
Methocarbamol Approved, Vet_approved Phase 4 532-03-6 4107
17
Levobupivacaine Approved, Investigational Phase 4 27262-47-1 92253
18
Clonidine Approved Phase 4 4205-91-8, 4205-90-7 2803 20179
19
Tamsulosin Approved, Investigational Phase 4 106133-20-4 129211
20
Glutamic acid Approved, Nutraceutical Phase 4 56-86-0 33032
21
Imidacloprid Vet_approved Phase 4 105827-78-9 86418
22 Calcium, Dietary Phase 4
23 Anesthetics, Dissociative Phase 4
24 Central Nervous System Stimulants Phase 4
25 Phosphodiesterase Inhibitors Phase 4
26 Anesthetics, Intravenous Phase 4
27 Anesthetics, General Phase 4
28 Hypnotics and Sedatives Phase 4
29 Analgesics, Non-Narcotic Phase 4
30 Antirheumatic Agents Phase 4
31 Cyclooxygenase Inhibitors Phase 4
32 Anti-Inflammatory Agents, Non-Steroidal Phase 4
33 Anti-Inflammatory Agents Phase 4
34 Antipyretics Phase 4
35 Fibrin Tissue Adhesive Phase 4
36 Antibiotics, Antitubercular Phase 4
37 Anti-Bacterial Agents Phase 4
38 Anti-Infective Agents Phase 4
39 Parasympatholytics Phase 4
40 Anti-Arrhythmia Agents Phase 4
41 Sodium Channel Blockers Phase 4
42 Diuretics, Potassium Sparing Phase 4
43 Gentamicins Phase 4
44 Analgesics, Opioid Phase 4
45 Narcotics Phase 4
46 Adrenergic alpha-Agonists Phase 4
47 Adrenergic Agonists Phase 4
48 Antihypertensive Agents Phase 4
49 Sympatholytics Phase 4
50 Neurotransmitter Agents Phase 4

Interventional clinical trials:

(show top 50) (show all 429)
# Name Status NCT ID Phase Drugs
1 Effects of Transverse Abdominis Plane Block Guided by Ultrasound on the Postoperative Analgesia and Quality of Lives Among the Patients Undergo Inguinal Hernia Repair Unknown status NCT02292095 Phase 4
2 Controlled Release of Oxycodone 10 mg In Pre-Medication For The Post Operative Analgesia In Elective Laparoscopic Bilateral Inguinal Hernia And Elective Laparoscopic Cholecystectomy : Prospective Double Blind, Randomized, Placebo-Controlled Study Unknown status NCT00480142 Phase 4 Oxycodone 10 mg
3 Early Outcome of Inguinal Hernia Repair With Biomerix Surgical Mesh Using the Lichtenstein Technique Unknown status NCT00924755 Phase 4
4 The Impact of Perioperative Gabapentin on Chronic Groin Pain After Inguinal Hernia Repair Unknown status NCT02419443 Phase 4 Gabapentin;Placebo
5 Does Ultrasound-guided Ilioinguinal-iliohypogastric Block Improve Postoperative Pain Outcome After Unilateral Inguinal Hernia Repair? Unknown status NCT01326039 Phase 4 bupivacaine;saline
6 The Effect of Different Doses of Ketamine on Tracheal Intubating Conditions Using Low Dose Rocuronium in Children Unknown status NCT02646709 Phase 4 Rocuronium;ketamine 1;ketamine 1.5;ketamine 2
7 Multicentre Randomised Controled Trial Comparing the Effect of a New Self-gripping Lightweight Polyester Mesh and a Normal Sutured Lightweight Polyester Mesh on the Incidence of Chronic Inguinodynia in Lichtenstein Hernioplasty. Unknown status NCT01830452 Phase 4
8 Rebound Hernia Repair Device Trial Unknown status NCT00968773 Phase 4
9 Chronic Significant Pain and Functional Outcome After Laparoscopic Versus Open Groin Hernia Mesh Repair: Design of a Randomized Controlled Clinical Trial Unknown status NCT00625534 Phase 4
10 Early and Late Results of Transinguinal Preperitoneal Patch Repair Versus Anterior Pre-Trasversalis Mesh Repair. A Randomised Study Completed NCT01350830 Phase 4
11 Comparative Study of Safety and Efficacy of Heavyweight and Partially Absorbable Mesh in Inguinal Hernia Repair Completed NCT01877122 Phase 4
12 A Randomized, Double-blinded, Placebo-controlled Trial of the Effects of Infusing Local Anesthesia on Post-operative Pain During Laparoscopic Inguinal Hernia Repair Completed NCT02055053 Phase 4 0.5% Bupivicaine
13 The Comparison of Two Different Doses of Morphine Added to Spinal Bupivacaine for Inguinal Hernia Repair. Completed NCT02001948 Phase 4 intrathecal morphine 0.1 mg combined with intrathecal heavy bupivacaine 7.5 mg;intrathecal morphine 0.4 mg combined with intrathecal heavy bupivacaine 7.5 mg;intravenous cannulation and premedication
14 ProGrip Mesh Repair Versus Lichtenstein Mesh Repair: a Comparative Randomized Study in Primary Inguinal Hernia Completed NCT00827944 Phase 4
15 Selective Subarachnoid Anesthesia. Comparison of Hyperbaric Bupivacaine and Hyperbaric Prilocaine in Knee Arthroscopy and Inguinal Hernia Repair in Ambulatory Surgery Completed NCT01921231 Phase 4 Hyperbaric Prilocaine 1%;Hyperbaric bupivacaine 0.5%
16 A Multicenter Prospective Randomized Trial on Chronic Pain After Inguinal Hernia Repair Using a Selfgrip-mesh Completed NCT00820131 Phase 4
17 Comparision of the Use in Marcaine and Chloroprocaine in Rachianesthesia for the Surgical Correction of Inguinal Hernia. Completed NCT02049255 Phase 4 Chloroprocaine;Marcaine
18 Evaluation of Dexamethasone Added to the Usual Infiltration With Bupivacaine in Inguinal Hernia Repair Mesh Completed NCT03007927 Phase 4 Bupivacaine-Dexamethasone;Bupivacaine- physiological solution
19 Preoperative Administration of Tamsulosin for Prevention of Post Operative Urinary Retention in Males Undergoing Elective Inguinal Hernia Repair Completed NCT02958878 Phase 4 Tamsulosin;Placebo Oral Capsule
20 Comparing Non-fixation of Mesh to Mesh Fixation in Laparoscopic Total Extraperitoneal Inguinal Hernia Repair Under Spinal Anesthesia- A Randomized Controlled Trial Completed NCT01117337 Phase 4
21 Prospective Randomized, Double-blind, Controlled Trial Comparing Lichtenstein's Repair of Inguinal Hernia With Polypropylene Mesh Versus Surgisis ES Soft Tissue Graft Completed NCT00614419 Phase 4
22 Prolene Hernia System, Lichtenstein Mesh, and Plug-and-Patch for Primary Inguinal Hernia Repair - Three Year Outcome of a Prospective Randomised Controlled Trial Completed NCT00580177 Phase 4
23 Prospective, Controlled, Randomized Study to Evaluate Pain and Further Disabling Complications in Patients Undergoing Lichtenstein Technique for Primary Inguinal Hernia Repair by Fixing the Mesh With Fibrin Sealant Versus Sutures Completed NCT00306839 Phase 4
24 Lichtenstein's Repair of Inguinal Hernia With Polypropylene Mesh Versus Infinit® PTFE Mesh, a Prospective Randomized, Double-blind, Controlled Trial Completed NCT01141335 Phase 4
25 ZIH Study : Comparison of Oral Zaldiar (Combination of Paracetamol and Tramadol) With Intravenous Paracetamol and Tramadol for Postoperative Analgesia After Inguinal Hernia Repair Completed NCT02389361 Phase 4 Zaldiar;Paracetamol-Tramadol
26 Analgesic Efficacy of Ultrasound-guided Inguinal Field Block (Genitofemoral, Iliohypogastric and Ilioinguinal Nerve Block) for Inguinal Hernia Surgery. Completed NCT01521481 Phase 4
27 Evaluation of the Analgesic Effect of Tramadol Wound Infiltration in Children Under Inguinal Hernioplasty. A Double-blind, Randomized Study. Completed NCT01943760 Phase 4 tramadol;0.9% saline
28 Investigation of the Effectiveness of Tizanidine on Pain After Herniorrhaphy Completed NCT02016443 Phase 4 Tizanidine;Placebo
29 A Multi-site Randomised Controlled Trial Comparing Regional and General Anaesthesia for Effects on Neurodevelopmental Outcome and Apnoea in Infants Completed NCT00756600 Phase 4 Regional Anesthesia;General Anesthesia
30 Comparison of Postoperative Analgesic Effects of Transversus Abdominis Plane Block and Quadratus Lumborum Block Type 2 Completed NCT03126084 Phase 4 Acetaminophen;0.25% Bupivacaine;0.5% Bupivacaine+Glucose;Tramadol HCl
31 Comparative Efficacy of Intravenous Acetaminophen vs. Oral Acetaminophen in Ambulatory Surgery Completed NCT03558555 Phase 4 Acetaminophen IV Soln;Oral Acetaminophen;Placebo Pills;Saline
32 Intraoperative Wound Instillation of Levobupivacaine is Effective in Postoperative Pain Management for Hernia Repair in Children: a Randomized Controlled Clinical Trial Completed NCT04869046 Phase 4 Instillation of levobupivacaine in surgical wound
33 Single Dose Antibiotic Prophylaxis in Lihtenstein Repair for Primary Inguinal Hernias Completed NCT01264003 Phase 4 sefazolin
34 Is Topical Antibiotic Prophylaxis Effective in Lichtenstein Hernia Repair: a Comparison Study Completed NCT01273818 Phase 4 Gentamicin and cefazolin;Cefazolin;Gentamicin
35 A Comparison of the Recovery Profiles of Bupivacaine or Bupivacaine Mixed With Lidocaine Spinal Anesthesia and Local Infiltration Anesthesia for Outpatient Herniorrhaphy Completed NCT01548794 Phase 4
36 Prospective, Randomized, Controlled, Third-Party Blinded Multicenter Evaluation of Strattice/LTM in the Repair of Inguinal Hernias Completed NCT00681291 Phase 4
37 THE EFFECT OF DIFFERENT INDUCTION TECHNIQUES ON POSTOPERATIVE PAIN AND AGITATION IN CHILDREN Completed NCT02110745 Phase 4 Sevofluorane;Propofol
38 Evaluation of Postoperative Pain Following Laparoscopic Hernia Repair: A Prospective, Randomized Comparison to Evaluate the Incidence of Post-operative Pain Associated With Absorbable Fixation (AbsorbaTack) vs Conventional Fixation (ProTack) Following Laparoscopic Hernia Repair Completed NCT00749268 Phase 4
39 The Efficacy of Transversus Abdominis Plane Block Versus Placebo Versus Local Infiltration in Patients Undergoing Groin Hernia Repair in Day Case Surgery. Completed NCT01052285 Phase 4
40 Randomized, Quadruple Blinded, Placebo Controlled, Multi-centered Trial Investigating Prophylactic Tamsulosin in Prevention of Postoperative Urinary Retention in Men After Endoscopic Total Extraperitoneal Inguinal Hernia Repair Recruiting NCT04491526 Phase 4 TAMSULOSIN Mepha Ret Depocaps 0.4 mg;Control Intervention
41 Addition of Methocarbamol to Postoperative Multimodal Analgesic Regimen: A Prospective, Randomized Pilot Study Recruiting NCT05388929 Phase 4 Methocarbamol;Standard Opioid;Standard opioid plus methocarbamol
42 The Effect of Local Anesthetic and Clonidine on the Cutaneous Silent Period During and After Spinal Anesthesia Active, not recruiting NCT03121261 Phase 4 levobupivacaine;clonidine
43 The Use of Tamsulosin to Prevent Postoperative Urinary Retention in Laparoscopic Inguinal Hernia Repair: A Randomized Double-Blind Placebo-Controlled Study Terminated NCT04434378 Phase 4 Tamsulosin;Placebo
44 An Expertise-based Multicentre Randomized Controlled Trial Comparing a Heavy-weight and a Light-weight Mesh in the Operation of Inguinal Hernia Unknown status NCT00451893 Phase 2, Phase 3
45 Laparoscopic-assisted Transversus Abdominis Plane (TAP) Block for Laparoscopic Total Extra Peritoneal (TEP) Inguinal Hernia Repair: a Prospective, Double-blinded, Randomized, Clinical Trial Unknown status NCT02632136 Phase 3 TAP Block Group;Peri-Portal Block Group
46 Pre-emptive Intravenous Analgesia for Elective Inguinal Hernia Repair: Prospective Randomized Double-blinded Placebo Controlled Comparison of Lornoxicam and Paracetamol Unknown status NCT01069055 Phase 3 Intravenous lornoxicam;Intravenous paracetamol
47 Use of Acellular Dermal in the Incarcerated Inguinal Hernia Tension-free Reconstructions Unknown status NCT02469142 Phase 2, Phase 3
48 Efficacy of Pre-operative Oral Pregabalin in Ambulatory Inguinal Hernia Repair for Post Operative Pain Unknown status NCT01450345 Phase 3 Pregabalin
49 Does Soaking Synthetic Mesh in Vancomycin Solution Reduce Mesh Infections in Open Hernia Repairs? Unknown status NCT01860469 Phase 2, Phase 3
50 The Prospective Randomized Comparison of the Onset Time of Rocuronium in Patients Undergoing Emergency and Elective Surgery Unknown status NCT02634255 Phase 3 Rocuronium elective surgery;Rocuronium emergency surgery;Propofol;Fentanyl

Search NIH Clinical Center for Inguinal Hernia

Cochrane evidence based reviews: hernia, inguinal

Sources

Genetic Tests for Inguinal Hernia

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Genetic tests related to Inguinal Hernia:

# Genetic test Affiliating Genes
1 Inguinal Hernia 28
Sources

Anatomical Context for Inguinal Hernia

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Organs/tissues related to Inguinal Hernia:

MalaCards : Colon, Liver, Testis, Appendix, Small Intestine, Uterus, Testes
Sources

Publications for Inguinal Hernia

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Articles related to Inguinal Hernia:

(show top 50) (show all 13376)
# Title Authors PMID Year
1
Preoperative oral granisetron for the prevention of vomiting following paediatric surgery. 53 62
11903942 2002
2
A role for the collagen I/III and MMP-1/-13 genes in primary inguinal hernia? 53 62
11872152 2002
3
Prophylactic therapy with combined granisetron and dexamethasone for the prevention of post-operative vomiting in children. 53 62
10434165 1999
4
Synthesis of type I and III collagen, expression of fibronectin and matrix metalloproteinases-1 and -13 in hernial sac of patients with inguinal hernia. 53 62
11341610 1999
5
Granisetron reduces post-operative vomiting in children: a dose-ranging study. 53 62
10084103 1999
6
Incarceration of a colonoscope in an inguinal hernia: A report of two cases. 62
36247312 2023
7
Using an E-Health Application for Post-operative Monitoring After Inguinal Hernia Repair: A Feasibility Study. 62
35604449 2023
8
Plug inguinal hernia repair mimicking nodal spread of prostate cancer on PSMA-PET/CT. 62
36324838 2023
9
Emergency laparoscopic trans-abdominal pre-peritoneal repair (TAPP) for irreducible inguinal hernia in Covid-19 patient: A case report and literature review. 62
36471717 2023
10
Risk of bowel resection in incarcerated inguinal hernia: watch out for ASA score and hernia type. 62
35974249 2022
11
Kingsnorth's modified score as predictor of complications in open inguinal hernia repair. 62
35943664 2022
12
Two-point Fixation for Biological Mesh in Laparoscopic Inguinal Hernia Repair. 62
36474370 2022
13
Learning curve of robotic inguinal hernia repair in the hands of an experienced laparoscopic surgeon: a comparative study. 62
35066790 2022
14
Incarcerated appendix epiploica in a right inguinal hernia sac. 62
36453781 2022
15
Comparison of BMI on operative time and complications of robotic inguinal hernia repair at a VA medical center. 62
35543772 2022
16
YouTube-Friend or Foe? A Closer Look at Videos on Inguinal Hernia Surgery as a Source for Patient Education. 62
36081310 2022
17
The transition from open to laparoscopic surgery for bilateral inguinal hernia repair: how we did it. 62
36070031 2022
18
eTEP inferior access with tailored retromuscular dissection for small to mid-sized umbilical hernia repair with or without inguinal hernia: early experience. 62
35962875 2022
19
MPS VII - Extending the classical phenotype. 62
36299251 2022
20
Transverse testicular ectopia with persistent Mullerian duct syndrome: Report and review of two cases. 62
36357339 2022
21
Comparison study of three laparoscopic ligation procedures for pediatric inguinal hernia: a multicenter cohort of 5523 cases. 62
35504975 2022
22
Asymptomatic contralateral inguinal and ventral hernias among people with a workers' compensation claim for hernia. 62
34776360 2022
23
Predictors of low and high opioid tablet consumption after inguinal hernia repair: an ACHQC opioid reduction task force analysis. 62
36036822 2022
24
Safety of laparoscopic inguinal hernia repair in the setting of antithrombotic therapy. 62
35674797 2022
25
A case of giant necrotic spermatic cord lipoma found incidentally during recurrent inguinal hernia repair: A case report. 62
36370603 2022
26
Automatic surgical phase recognition in laparoscopic inguinal hernia repair with artificial intelligence. 62
35536371 2022
27
Robotic single-port surgery: Preliminary experience in general surgery. 62
35962708 2022
28
Skipping the cord during laparoscopic percutaneous internal ring suturing in children, is it reasonable? 62
36255491 2022
29
Cost analysis of training residents in robotic-assisted surgery. 62
36471060 2022
30
Telemedicine-based new patient consultations for hernia repair and advanced abdominal wall reconstruction. 62
35723771 2022
31
Obesity Stratification Predicts Short-Term Complications After Parastomal Hernia Repair. 62
35952554 2022
32
Trends in Robot-Assisted Procedures for General Surgery in the Veterans Health Administration. 62
35970011 2022
33
A 6-year retrospective clinical review of iatrogenic ureteric injuries repaired in a resource-deprived setting. 62
36335342 2022
34
Combined pantaloon and femoral hernia: a common pathology in medicine occurring simultaneously. 62
36415722 2022
35
Cirrhosis and hernia repair in a cohort of 6352 patients in a tertiary hospital: Risk assessment and survival analysis. 62
36397364 2022
36
Comparing the Efficacy of Dorsal Root Ganglion Stimulation With Conventional Medical Management in Patients With Chronic Postsurgical Inguinal Pain: Post Hoc Analyzed Results of the SMASHING Study. 62
36456417 2022
37
Technical aspects of inguino scrotal hernia surgery in developing countries. 62
36449178 2022
38
Dynamic Responsive Inguinal Scaffold Activates Myogenic Growth Factors Finalizing the Regeneration of the Herniated Groin. 62
36412894 2022
39
Robot-Assisted General Surgery Procedures at the Veterans Health Administration: A Comparison of Surgical Techniques. 62
35810550 2022
40
The impact of value-driven outcomes initiative on endo-laparoscopic groin hernia repair. 62
36427167 2022
41
Comprehensive History and Physicals are Common Before Low-Risk Surgery and Associated With Preoperative Test Overuse. 62
36399802 2022
42
Inguinal bladder hernia: differentials for a male groin mass. 62
36340598 2022
43
Can ventral TAPP achieve favorable outcomes in minimally invasive ventral hernia repair? A systematic review and meta-analysis. 62
36378412 2022
44
Laparoscopic mesh removal for chronic postoperative inguinal pain following endoscopic hernia repair: a cohort study on the effect on pain. 62
36445507 2022
45
New Persistent Opioid Use After Inguinal Hernia Repair. 62
33065653 2022
46
Effects of ultrasound guided caudal epidural and transversus abdominis plane block on postoperative analgesia in pediatric inguinal hernia repair surgeries. 62
36446689 2022
47
Single-Incision Pediatric Laparoscopic Surgery: Surgical Outcomes, Feasibility Indication, and the Systematic Review. 62
35900259 2022
48
Neonatal adrenal hemorrhage presenting as an acute scrotum: A case report on the rare presentation of right adrenal hemorrhage and contralateral left scrotal hematoma. 62
36341198 2022
49
The Importance of Radiologic Imaging Modalities in Autosomal Dominant Polycystic Kidney Disease. 62
36408304 2022
50
Further characterization of NFIB-associated phenotypes: Report of two new individuals. 62
36321570 2022
Sources

Variations for Inguinal Hernia

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ClinVar genetic disease variations for Inguinal Hernia:

5 (show all 12)
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 overlap with 29 genes GRCh37/hg19 22q11.21(chr22:18894835-20311763) CN LOSS Pathogenic
 523273 GRCh37: 22:18894835-20311763
GRCh38:
2 EFEMP1 NM_001039348.3(EFEMP1):c.320_324del (p.Met107fs) DEL Pathogenic
 691884 rs1572850869 GRCh37: 2:56144993-56144997
GRCh38: 2:55917858-55917862
3 EFEMP1 NM_001039348.3(EFEMP1):c.615T>A (p.Tyr205Ter) SNV Pathogenic
 691885 rs765517862 GRCh37: 2:56108772-56108772
GRCh38: 2:55881637-55881637
4 overlap with 39 genes DEL Pathogenic
 1684661 GRCh37:
GRCh38: 16:29640592-30187862
5 CEMIP2 NM_013390.3(CEMIP2):c.1358G>A (p.Cys453Tyr) SNV Pathogenic
 827846 rs755447989 GRCh37: 9:74349757-74349757
GRCh38: 9:71734841-71734841
6 CEMIP2 NM_013390.3(CEMIP2):c.3144G>A (p.Trp1048Ter) SNV Pathogenic
 827847 rs766829965 GRCh37: 9:74319561-74319561
GRCh38: 9:71704645-71704645
7 FBN1 NM_000138.5(FBN1):c.840_843del (p.Asn280fs) DEL Pathogenic
 374115 rs1057518909 GRCh37: 15:48826296-48826299
GRCh38: 15:48534099-48534102
8 NF1 NM_001042492.3(NF1):c.7482G>A (p.Trp2494Ter) SNV Pathogenic
 216067 rs863224493 GRCh37: 17:29679299-29679299
GRCh38: 17:31352281-31352281
9 ACTL6A NM_004301.5(ACTL6A):c.1129C>T (p.Arg377Trp) SNV Likely Pathogenic
 549661 rs868064163 GRCh37: 3:179304340-179304340
GRCh38: 3:179586552-179586552
10 COL5A1 NM_000093.5(COL5A1):c.608G>T (p.Gly203Val) SNV Likely Pathogenic
 523328 rs1554781700 GRCh37: 9:137593133-137593133
GRCh38: 9:134701287-134701287
11 LSM1 NM_014462.3(LSM1):c.231+4A>C SNV Uncertain Significance
 623485 rs775468919 GRCh37: 8:38027316-38027316
GRCh38: 8:38169798-38169798
12 ELN NM_000501.4(ELN):c.898A>T (p.Thr300Ser) SNV Uncertain Significance
 523433 rs766735416 GRCh37: 7:73466262-73466262
GRCh38: 7:74051932-74051932
Sources

Expression for Inguinal Hernia

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Search GEO for disease gene expression data for Inguinal Hernia.
Sources

Pathways for Inguinal Hernia

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Pathways related to Inguinal Hernia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Integrin Pathway 64
Show member pathways
 13.16 MMP13 MMP1 FBN1 ELN EFEMP2 EFEMP1
2
Phospholipase-C Pathway 64
Show member pathways
 12.69 LTBP1 FBN1 ELN EFEMP2 EFEMP1 COL5A1
3
Signaling by TGFB family members 66
Show member pathways
 12.13 LTBP1 FBN1 AMHR2 AMH
4
Extracellular matrix organization 66
Show member pathways
 11.92 MMP13 MMP1 LTBP1 FBN1 FBLN5 ELN
5
7q11.23 copy number variation syndrome 74
11.56 FBN1 FBLN5 ELN
6
Burn wound healing 74
11.46 MMP1 FBN1 ELN
7
Elastic fibre formation 66
Show member pathways
 11.34 LTBP1 FBN1 FBLN5 ELN EFEMP2 EFEMP1
8
Mammalian disorder of sexual development 74
Show member pathways
 11.15 INSL3 GATA4 AMHR2 AMH
9
G-protein signaling_Rap2B regulation pathway 22
10.64 COL5A1 EFEMP1 EFEMP2 ELN FBN1 LTBP1
10
ALK2 signaling events 61
10.32 AMHR2 AMH
Sources

GO Terms for Inguinal Hernia

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Cellular components related to Inguinal Hernia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10.37 MMP13 MMP1 LTBP1 INSL3 FBN1 FBLN5
2 collagen-containing extracellular matrix GO:0062023 10 COL5A1 EFEMP1 EFEMP2 ELN FBLN5 FBN1
3 microfibril GO:0001527 9.8 LTBP1 FBN1 EFEMP2
4 extracellular matrix GO:0031012 9.62 MMP13 MMP1 LTBP1 FBN1 FBLN5 ELN
5 elastic fiber GO:0071953 9.43 FBLN5 ELN EFEMP2

Biological processes related to Inguinal Hernia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 male gonad development GO:0008584 9.76 INSL3 GATA4 AR AMHR2
2 embryonic eye morphogenesis GO:0048048 9.67 FBN1 EFEMP1
3 sequestering of TGFbeta in extracellular matrix GO:0035583 9.62 LTBP1 FBN1
4 Mullerian duct regression GO:0001880 9.56 AMHR2 AMH
5 extracellular matrix organization GO:0030198 9.36 NF1 MMP13 MMP1 ELN COL5A1 ADAMTS6
6 post-embryonic eye morphogenesis GO:0048050 9.26 FBN1 EFEMP1

Molecular functions related to Inguinal Hernia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 calcium ion binding GO:0005509 10.06 MMP13 LTBP1 FBN1 FBLN5 EFEMP2 EFEMP1
2 extracellular matrix constituent conferring elasticity GO:0030023 9.43 FBN1 FBLN5 ELN
3 extracellular matrix structural constituent GO:0005201 9.4 LTBP1 FBN1 ELN EFEMP2 EFEMP1 COL5A1
Sources

Sources for Inguinal Hernia

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2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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