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MCID: ING001
MIFTS: 59

Inguinal Hernia

Categories: Gastrointestinal diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Inguinal Hernia

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MalaCards integrated aliases for Inguinal Hernia:

Name: Inguinal Hernia 12 76 29 6 15
Hernia, Inguinal 44
Hernia Inguinal 55

Classifications:

MalaCards categories:
Anatomical: Gastrointestinal diseases
See all MalaCards categories (disease lists)
ICD10: 33


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Summaries for Inguinal Hernia

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Disease Ontology : 12 An intestinal disease characterized by a protrusion of abdominal cavity contests through the inguinal canal.

MalaCards based summary : Inguinal Hernia, also known as hernia, inguinal, is related to aortic aneurysm and appendicitis. An important gene associated with Inguinal Hernia is FBN1 (Fibrillin 1), and among its related pathways/superpathways are Integrin Pathway and Phospholipase-C Pathway. The drugs Bupivacaine and Dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include colon, testis and testes, and related phenotypes are cardiovascular system and growth/size/body region

Wikipedia : 76 An inguinal hernia is a protrusion of abdominal-cavity contents through the inguinal canal. Symptoms are... more...

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Related Diseases for Inguinal Hernia

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Diseases related to Inguinal Hernia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 225)
# Related Disease Score Top Affiliating Genes
1 aortic aneurysm 30.8 ELN FBN1 MMP13
2 appendicitis 30.4 IL6 MMP9 TIMP1
3 pneumothorax 30.3 ELN FBN1 MMP2 MMP9
4 aortic disease 29.2 ELN FBN1 IL6 MMP2 MMP9 TIMP1
5 aortic aneurysm, familial abdominal, 1 28.9 ELN FBN1 IL6 MMP1 MMP13 MMP2
6 heart disease 28.8 ELN FBN1 GATA6 IL6 TBX1 TTN
7 arthrogryposis multiplex with deafness, inguinal hernias, and early death 12.2
8 marfanoid habitus-inguinal hernia-advanced bone age syndrome 12.1
9 lambert syndrome 11.8
10 persistent mullerian duct syndrome 11.4
11 pseudomyxoma peritonei 11.4
12 mucopolysaccharidosis, type ii 11.3
13 cutis laxa, autosomal recessive, type ia 11.2
14 short syndrome 11.2
15 achondrogenesis, type ib 11.2
16 spondylocostal dysostosis 3, autosomal recessive 11.2
17 acrofacial dysostosis, catania type 11.0
18 hyperekplexia 1 11.0
19 spinal muscular atrophy, x-linked 2 11.0
20 aarskog-scott syndrome 11.0
21 opitz-kaveggia syndrome 11.0
22 exstrophy of bladder 11.0
23 bosma arhinia microphthalmia syndrome 11.0
24 testicular anomalies with or without congenital heart disease 11.0
25 autosomal recessive cutis laxa type i 11.0
26 2q37 deletion syndrome 11.0
27 deafness, epiphyseal dysplasia, short stature 11.0
28 ichthyosis follicularis atrichia photophobia syndrome 11.0
29 pseudoxanthoma elasticum-like papillary dermal elastolysis 10.9 ELN FBN1
30 late-onset focal dermal elastosis 10.9 ELN FBN1
31 familial abdominal aortic aneurysm 10.9 ELN FBN1
32 extracranial arteriovenous malformation 10.9 MMP2 MMP9
33 tonsil squamous cell carcinoma 10.8 MMP13 TIMP2
34 focal myositis 10.8 MMP2 MMP9
35 metaphyseal anadysplasia 10.8 MMP13 MMP9
36 lentigo maligna melanoma 10.7 MMP2 MMP9
37 spastic entropion 10.7 MMP1 MMP2 MMP9
38 bone structure disease 10.7 FBN1 MMP13 NF1
39 mitral valve disease 10.7 FBN1 MMP1 MMP13
40 internal hemorrhoid 10.7 MMP1 MMP2 MMP9
41 light chain deposition disease 10.7 MMP1 MMP2 MMP9
42 nodular malignant melanoma 10.7 MMP1 MMP2 TIMP2
43 odontogenic myxoma 10.7 MMP1 MMP2 MMP9
44 supravalvular aortic stenosis 10.7 ELN FBN1 MMP2
45 localized scleroderma 10.7 IL6 MMP1 MMP13
46 senile ectropion 10.7 ELN MMP2 MMP9
47 exfoliation syndrome 10.7 ELN FBN1 MMP1
48 preterm premature rupture of the membranes 10.7 IL6 MMP1 TIMP2
49 autoimmune inner ear disease 10.7 MMP9 TIMP1
50 hypertensive heart disease 10.7 MMP1 MMP2 MMP9

Graphical network of the top 20 diseases related to Inguinal Hernia:



Diseases related to Inguinal Hernia
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Symptoms & Phenotypes for Inguinal Hernia

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MGI Mouse Phenotypes related to Inguinal Hernia:

46 (show all 21)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.52 ADAMTS6 AR EFEMP1 FBN1 GATA6 IL6
2 growth/size/body region MP:0005378 10.47 ADAMTS6 AR EBF2 EFEMP1 FBN1 GATA6
3 homeostasis/metabolism MP:0005376 10.46 ADAMTS6 AR EFEMP1 FBN1 GATA6 IL6
4 behavior/neurological MP:0005386 10.34 AR EBF2 EFEMP1 FBN1 IL6 ITGA3
5 immune system MP:0005387 10.34 ADAMTS6 AR EFEMP1 FBN1 IL6 ITGA3
6 cellular MP:0005384 10.32 AR EBF2 FBN1 GATA6 IL6 ITGA3
7 mortality/aging MP:0010768 10.31 AR EBF2 EFEMP1 FBN1 GATA6 IL6
8 hematopoietic system MP:0005397 10.3 NF1 TBX1 TIMP1 TIMP2 ADAMTS6 AR
9 endocrine/exocrine gland MP:0005379 10.29 ADAMTS6 AR EBF2 EFEMP1 FBN1 IL6
10 craniofacial MP:0005382 10.27 ADAMTS6 AR EBF2 FBN1 MMP2 NF1
11 digestive/alimentary MP:0005381 10.27 ADAMTS6 AR EFEMP1 IL6 ITGA3 MMP9
12 limbs/digits/tail MP:0005371 10.27 TBX2 TBX3 TIMP1 ADAMTS6 AR EBF2
13 embryo MP:0005380 10.21 AR FBN1 GATA6 ITGA3 NF1 TBX1
14 integument MP:0010771 10.18 AR EFEMP1 FBN1 IL6 ITGA3 MMP13
15 muscle MP:0005369 10.14 MMP2 MMP9 NF1 TBX1 TBX3 TTN
16 normal MP:0002873 10.06 TBX2 TBX3 TIMP2 TTN AR EBF2
17 neoplasm MP:0002006 9.97 AR IL6 ITGA3 MMP1 MMP2 MMP9
18 reproductive system MP:0005389 9.81 GATA6 IL6 MMP9 TBX3 TIMP1 FBN1
19 renal/urinary system MP:0005367 9.8 AR EFEMP1 FBN1 IL6 ITGA3 MMP9
20 respiratory system MP:0005388 9.65 EBF2 FBN1 GATA6 IL6 ITGA3 MMP2
21 skeleton MP:0005390 9.47 ADAMTS6 AR EBF2 EFEMP1 FBN1 IL6
Sources

Drugs & Therapeutics for Inguinal Hernia

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Drugs for Inguinal Hernia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 176)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bupivacaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 2180-92-9, 38396-39-3 2474
2
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Not Applicable 50-02-2 5743
3
Ropivacaine Approved Phase 4,Not Applicable 84057-95-4 71273 175805
4
Tramadol Approved, Investigational Phase 4,Not Applicable 27203-92-5 33741
5
Oxycodone Approved, Illicit, Investigational Phase 4,Phase 3 76-42-6 5284603
6
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
7
gamma-Aminobutyric acid Approved, Investigational Phase 4 56-12-2 119
8
Ketamine Approved, Vet_approved Phase 4,Phase 2 6740-88-1 3821
9
Rocuronium Approved Phase 4,Phase 3,Not Applicable 119302-91-9, 143558-00-3 441290
10
Midazolam Approved, Illicit Phase 4,Phase 3,Phase 2,Not Applicable 59467-70-8 4192
11
Morphine Approved, Investigational Phase 4,Phase 3,Not Applicable 57-27-2 5288826
12
Ibuprofen Approved Phase 4,Phase 3,Not Applicable 15687-27-1 3672
13
Acetaminophen Approved Phase 4,Phase 3,Not Applicable 103-90-2 1983
14
Levobupivacaine Approved, Investigational Phase 4,Phase 2,Not Applicable 27262-47-1 92253
15
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2 1994-09-7, 94-09-7 2337
16
Lidocaine Approved, Vet_approved Phase 4,Phase 3,Not Applicable 137-58-6 3676
17
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 3,Not Applicable 2078-54-8 4943
18
Cefazolin Approved Phase 4,Phase 3 25953-19-9 656510 33255
19
Chloroprocaine Approved Phase 4 133-16-4 8612
20
Procaine Approved, Investigational, Vet_approved Phase 4 59-46-1 4914
21
Clonidine Approved Phase 4,Phase 3 4205-90-7 2803
22
Tizanidine Approved, Investigational Phase 4 51322-75-9 5487
23
Prilocaine Approved Phase 4 721-50-6 4906
24
Sevoflurane Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 28523-86-6 5206
25
Naproxen Approved, Vet_approved Phase 4 22204-53-1 1302 156391
26
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
27
Remifentanil Approved Phase 4,Not Applicable 132875-61-7 60815
28
Ondansetron Approved Phase 4,Not Applicable 99614-02-5 4595
29
Tamsulosin Approved, Investigational Phase 4,Early Phase 1 106133-20-4 129211
30
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
31
Droperidol Approved, Vet_approved Phase 4 548-73-2 3168
32
Ketobemidone Approved, Investigational Phase 4 469-79-4 10101
33
Meperidine Approved Phase 4 57-42-1 4058
34
Caffeine Approved, Nutraceutical Phase 4 58-08-2 2519
35
Glutamic Acid Approved, Nutraceutical Phase 4 56-86-0 33032
36 tannic acid Approved, Nutraceutical Phase 4,Phase 3,Phase 2
37 Central Nervous System Stimulants Phase 4
38 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
39 Phosphodiesterase Inhibitors Phase 4
40 Purinergic P1 Receptor Antagonists Phase 4
41 Anesthetics Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
42 Anesthetics, Local Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
43 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
44 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
45 Analgesics Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
46 Analgesics, Opioid Phase 4,Phase 3,Not Applicable
47 Antiemetics Phase 4,Phase 3,Not Applicable
48 Anti-Inflammatory Agents Phase 4,Phase 3,Not Applicable
49 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Not Applicable
50 Autonomic Agents Phase 4,Phase 3,Phase 2,Not Applicable

Interventional clinical trials:

(show top 50) (show all 297)
# Name Status NCT ID Phase Drugs
1 Comparative Study on Self-adhesive Mesh for Open Inguinal Hernia Repair Unknown status NCT00960011 Phase 4
2 Study of Surgical Mesh for Inguinal Hernia Repair Unknown status NCT00924755 Phase 4
3 Ultrasound-guided Ilioinguinal-iliohypogastric Block for Inguinal Hernia Repair Unknown status NCT01326039 Phase 4 bupivacaine;saline
4 Effects of Transverse Abdominis Plane Block Guided by Ultrasound on the Postoperative Analgesia and Quality of Lives Among the Patients Undergo Inguinal Hernia Repair Unknown status NCT02292095 Phase 4
5 Controlled Release of Oxycodone 10 mg In Pre-Medication For The Post Operative Analgesia In Elective Laparoscopic Bilateral Inguinal Hernia And Elective Laparoscopic Cholecystectomy Unknown status NCT00480142 Phase 4 Oxycodone 10 mg
6 The Impact of Perioperative Gabapentin on Chronic Groin Pain After Inguinal Hernia Repair Unknown status NCT02419443 Phase 4 Gabapentin;Placebo
7 Rebound Hernia Repair Device Mesh Trial Unknown status NCT00968773 Phase 4
8 Functional Outcome After Groin Hernia Mesh Repair: Open Versus Laparoscopy Unknown status NCT00625534 Phase 4
9 Effect of Intraoperative Infiltration With Bupivacain on the Development of Chronic Pain After Inguinal Hernia Repair Unknown status NCT00484731 Phase 4
10 Less Chronic Pain After Lichtenstein Hernioplasty Using the Self-gripping Parietex Progrip Mesh Unknown status NCT01830452 Phase 4
11 The Effect of Different Dose of Ketamine With Low Dose Rocuronium in Children Unknown status NCT02646709 Phase 4 Rocuronium;ketamine 1;ketamine 1.5;ketamine 2
12 Exparel Injection for Postoperative Orbital Pain Unknown status NCT02381353 Phase 4 Bupivacaine
13 Comparing Non-fixation of Mesh to Mesh Fixation in Laparoscopic Inguinal Hernia Repair Completed NCT01117337 Phase 4
14 Antibiotic Prophylaxis in Mesh Repair of Inguinal Hernias Completed NCT01264003 Phase 4 sefazolin
15 Chronic Pain After Inguinal Hernia Repair Completed NCT00820131 Phase 4
16 Strattice in Repair of Inguinal Hernias Completed NCT00681291 Phase 4
17 Efficacy Study of Tissucol/Tisseel Fibrin Sealant to Treat Inguinal Hernia Completed NCT00306839 Phase 4
18 Ultrasound-guided Inguinal Field Block (Genitofemoral, Iliohypogastric and Ilioinguinal Nerve Block) for Inguinal Hernia Surgery Completed NCT01521481 Phase 4
19 PHS, Lichtenstein Mesh, and PerFixPlug for Primary Inguinal Hernia Repair - 3 Years Results Completed NCT00580177 Phase 4
20 Intrathecal Morphine for Inguinal Hernia Repair. Completed NCT02001948 Phase 4 intrathecal morphine 0.1 mg combined with intrathecal heavy bupivacaine 7.5 mg;intrathecal morphine 0.4 mg combined with intrathecal heavy bupivacaine 7.5 mg;intravenous cannulation and premedication
21 Prospective Randomized Trial Comparing Lichtenstein's Repair of Inguinal Hernia With Polypropylene Mesh Versus Surgisis Completed NCT00614419 Phase 4
22 Evaluation of Dexamethasone Added to the Usual Infiltration With Bupivacaine in Inguinal Hernia Repair Mesh Completed NCT03007927 Phase 4 Bupivacaine-Dexamethasone;Bupivacaine- physiological solution
23 Effectiveness of Topical Antibiotic Prophylaxis in Inguinal Hernia Repair Completed NCT01273818 Phase 4 Gentamicin and cefazolin;Cefazolin;Gentamicin
24 Comparision of the Use in Marcaine and Chloroprocaine in Rachianesthesia for the Surgical Correction of Inguinal Hernia. Completed NCT02049255 Phase 4 Chloroprocaine;Marcaine
25 Parietex Progrip Study Completed NCT00827944 Phase 4
26 Polypropylene Mesh Versus Polytetrafluoroethylene (PTFE) Mesh in Inguinal Hernia Repair Completed NCT01141335 Phase 4
27 Tizanidine and Pain After Herniorrhaphy Completed NCT02016443 Phase 4 Tizanidine;Placebo
28 Selective Subarachnoid Anesthesia. Comparison of Hyperbaric Bupivacaine and Hyperbaric Prilocaine Completed NCT01921231 Phase 4 Hyperbaric Prilocaine 1%;Hyperbaric bupivacaine 0.5%
29 Comparative Study of Safety and Efficacy of Heavyweight and Partially Absorbable Mesh in Inguinal Hernia Repair Completed NCT01877122 Phase 4
30 Postoperative Effects of TAP Block Versus QLB Type 2 Block Completed NCT03126084 Phase 4 Acetaminophen;0.25% Bupivacaine;0.5% Bupivacaine+Glucose;Tramadol HCl;0.25% Bupivacaine
31 Comparison of Oral Zaldiar With Intravenous Paracetamol and Tramadol Completed NCT02389361 Phase 4 Zaldiar;Paracetamol-Tramadol
32 Preperitoneal Versus Pre-trasversalis Hernia Repair Completed NCT01350830 Phase 4
33 Ultrasound-guided Rectus Sheath Block In Children Completed NCT02291705 Phase 4 Tramadol
34 Tamadol Wound Infiltration in Children Under Inguinal Hernioplasty Completed NCT01943760 Phase 4 tramadol;0.9% saline
35 Recovery of Bupivacaine or Bupivacaine-Lidocaine Spinal Anesthesia and Infiltration Anesthesia in Herniorrhaphy Completed NCT01548794 Phase 4
36 The Effect of Induction Technique on Postoperative Pain and Agitation Completed NCT02110745 Phase 4 Sevofluorane;Propofol
37 Comparison Of The Analgesia Obtained By Infiltration For The Joinings Of Episiotomies (Liropep) Completed NCT00727935 Phase 4 Lidocaïne;Ropivacaïne;Placebo
38 Controlled-Release Oxycodone Versus Naproxen at Home After Ambulatory Surgery: A Randomized Controlled Trial Completed NCT02152592 Phase 4 PCM/Oxy1;PCM/Oxy2
39 Effects of Local Anesthesia on Post-operative Pain During Laparoscopic Inguinal Hernia Repair Recruiting NCT02055053 Phase 4 0.5% Bupivicaine
40 Determine the Clinical Advantage of IV vs PO Acetaminophen Recruiting NCT03558555 Phase 4 Acetaminophen IV Soln;Oral Acetaminophen;Placebo Pills;Saline
41 Pilot Study: Postoperative Pain Reduction by Pre Emptive N-Acetylcysteine Recruiting NCT03354572 Phase 4 Acetyl cysteine;Placebos
42 A Multi-site Randomized Controlled Trial Comparing Regional and General Anesthesia for Effects on Neurodevelopmental Outcome and Apnea in Infants Active, not recruiting NCT00756600 Phase 4 Regional Anesthesia;General Anesthesia
43 The Effect of Local Anesthetic and Clonidine on the Cutaneous Silent Period During Spinal Anesthesia Active, not recruiting NCT03121261 Phase 4 levobupivacaine;clonidine
44 Influence of Anesthetic Technique on Acute and Chronic Neuropathic Pain Active, not recruiting NCT02527083 Phase 4 Propofol;Sevoflurane;Remifentanil;Ketamine
45 Preoperative Administration of Tamsulosin for Prevention of Post Operative Urinary Retention in Males Undergoing Elective Inguinal Hernia Repair Enrolling by invitation NCT02958878 Phase 4 Tamsulosin;Placebo Oral Capsule
46 Effectiveness of a Quadratus Lumborum 3 Block vs. a TAP-block for Inguinal Hernia Repair Not yet recruiting NCT03023462 Phase 4 Oksykodonhydroklorid;Ketobemidone Hydrochloride;Ondansetron and Droperidol;Ropivacaine
47 Does the Preoperative Midazolam Dose Affect Postoperative Pain? Not yet recruiting NCT03534895 Phase 4 Midazolam Injectable Solution;Postoperative analgesia;Rescue analgesia;Wound infiltration;Analgesia at home
48 Lap TAP Block for Laparoscopic TEP Inguinal Hernia Repair: a Prospective, Double-blinded, Randomized, Clinical Trial Unknown status NCT02632136 Phase 3 TAP Block Group;Peri-Portal Block Group
49 The Significance of the Mesh Thickness in the Operation of Inguinal Hernia Unknown status NCT00451893 Phase 2, Phase 3
50 Comparison of Lornoxicam and Paracetamol for Pre-emptive Intravenous Analgesia for Elective Inguinal Hernia Repair Unknown status NCT01069055 Phase 3 Intravenous lornoxicam;Intravenous paracetamol

Search NIH Clinical Center for Inguinal Hernia

Cochrane evidence based reviews: hernia, inguinal

Sources

Genetic Tests for Inguinal Hernia

About this section

Genetic tests related to Inguinal Hernia:

# Genetic test Affiliating Genes
1 Inguinal Hernia 29
Sources

Anatomical Context for Inguinal Hernia

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MalaCards organs/tissues related to Inguinal Hernia:

41
Colon, Testis, Testes, Prostate, Endothelial, Uterus, Ovary
Sources

Publications for Inguinal Hernia

About this section

Articles related to Inguinal Hernia:

(show top 50) (show all 426)
# Title Authors Year
1
Ultrasound guided quadratus lumborum block for postoperative analgesia in pediatric ambulatory inguinal hernia repair. ( 29414626 )
2018
2
Non-fixation Versus Fixation of Mesh in Totally Extraperitoneal Repair of Inguinal Hernia: a Comparative Study. ( 29915478 )
2018
3
Effect of addition of dexamethasone to ropivacaine on post-operative analgesia in ultrasonography-guided transversus abdominis plane block for inguinal hernia repair: A prospective, double-blind, randomised controlled trial. ( 29910495 )
2018
4
Reply to Comments to "Higher Recurrence Rate After Endoscopic Totally Extraperitoneal (TEP) Inguinal Hernia Repair with Ultrapro Lightweight Mesh: 5-Year Results of a Randomized Controlled Trial (TULP-trial)". ( 29979248 )
2018
5
Mesh migration into an inguinal hernia sac following a laparoscopic umbilical hernia repair. ( 29605843 )
2018
6
Comment to: Pre-peritoneal local anaesthetic does not reduce post-operative pain in laparoscopic total extra-peritoneal inguinal hernia repair: double-blinded randomized controlled trial. Kulasegaran S, Rohan M, Pearless L, Hulme-Moir M. ( 29356910 )
2018
7
Inseparable interaction of the prostate and inguinal hernia. ( 29923274 )
2018
8
Pre-operative Spermatic Cord Ultrasonography Helps to Reduce the Incidence of Metachronous Inguinal Hernia in Boys. ( 29915779 )
2018
9
Paravertebral blocks reduce the risk of postoperative urinary retention in inguinal hernia repair. ( 29909567 )
2018
10
Chronic pain, discomfort, quality of life and impact on sex life after open inguinal hernia mesh repair: an expertise-based randomized clinical trial comparing lightweight and heavyweight mesh. ( 29353339 )
2018
11
Closure of a direct inguinal hernia defect in laparoscopic repair with barbed suture: a simple method to prevent seroma formation? ( 28779243 )
2018
12
Do we really need a renaissance of pure tissue repair? Invited comment to: Desarda's technique versus Lichtenstein technique for the treatment of primary inguinal hernia: a systematic review and meta-analysis of randomized controlled trials. Emile S, Elfeki H. ( 29392507 )
2018
13
Efficacy of Laparoscopic Percutaneous Extraperitoneal Closure for Unilateral Inguinal Hernia in Children and Significance of Simple Exploration Maneuver for Contralateral Patent Processus Vaginalis: A Retrospective Study. ( 29966576 )
2018
14
Algorithm of Laparoscopic Technique in Pediatric Inguinal Hernia: Results from Experience of 10 Years. ( 29424624 )
2018
15
Opioid sparing effect of Erector Spinae Plane block for pediatric bilateral inguinal hernia surgeries. ( 29980003 )
2018
16
Ruptured Anastomotic Pseudoaneurysm of the Common Femoral Artery After Wrongful Diagnosis of Inguinal Hernia. ( 29448983 )
2018
17
As in Real Estate, Location Is What Matters: A Case Report of Transplant Ureteral Obstruction Due to an Inguinal Hernia. ( 29372065 )
2018
18
Prospective randomized study comparing single-incision laparoscopic versus multi-trocar laparoscopic totally extraperitoneal (TEP) inguinal hernia repair at 2 years. ( 29362907 )
2018
19
A study to compare caudal levobupivacaine, tramadol and a combination of both in paediatric inguinal hernia surgeries. ( 29910493 )
2018
20
The Ideal Size of Mesh for Open Inguinal Hernia Repair: A Morphometric Study in Patients with Inguinal Hernia. ( 29974028 )
2018
21
Effectiveness of endoscopic totally extraperitoneal (TEP) hernia correction for clinically occult inguinal hernia (EFFECT): study protocol for a randomized controlled trial. ( 29914545 )
2018
22
Parasitic leiomyoma presenting as an inguinal hernia in a postmenopausal woman. ( 29887930 )
2018
23
Case of chronic pain after laparoscopic percutaneous extraperitoneal closure in an adolescent girl with inguinal hernia in which open repair was effective. ( 29956498 )
2018
24
Trans-umbilical two-port laparoscopic suturing of the inguinal hernia defect with percutaneous assistance: a safe and efficient scarless surgery for pediatric inguinal hernia repair. ( 29417340 )
2018
25
Elective "True Day Case" Laparoscopic Inguinal Hernia Repair in a District General Hospital: Lessons Learned from 1000 Consecutive Cases. ( 29971162 )
2018
26
Self-fixing parietex progrip versus the standard sutured prolene mesh in tension-free repair of inguinal hernia: effect on testicular volume and testicular blood flow. ( 29948662 )
2018
27
Correction to: Patient perceptions of acute pain and activity disruption following inguinal hernia repair: a propensity-matched comparison of robotic-assisted, laparoscopic, and open approaches. ( 29915903 )
2018
28
The cumulative incidence and risk factors of postoperative inguinal hernia in patients undergoing radical prostatectomy. ( 29340839 )
2018
29
Fibrin glue versus staple mesh fixation in single-port laparoscopic totally extraperitoneal inguinal hernia repair: A propensity score-matched analysis. ( 29410137 )
2018
30
Laparoscopic inguinal hernia repair by modified peritoneal leaflet closure: Description and initial results in children. ( 29958645 )
2018
31
Erector spinae plane block for inguinal hernia repair in preterm infants. ( 29341379 )
2018
32
Outcomes of surgery on patients with a clinically inapparent inguinal hernia as diagnosed by ultrasonography. ( 29380157 )
2018
33
Giant interparietal inguinal hernia with undescended testis-A Rare case report. ( 29202353 )
2018
34
Learning Curves for Laparoscopic Repair of Inguinal Hernia and Communicating Hydrocele in Children. ( 29021976 )
2017
35
Bilateral inguinal hernia after axillary-femoral artery bypass effectively treated with laparoscopic repair: A case report. ( 28436213 )
2017
36
Extra-gastrointestinal anisakidosis caused by Pseudoterranova azarasi manifesting as strangulated inguinal hernia. ( 28927907 )
2017
37
Laparoscopic recurrent inguinal hernia repair during the learning curve: it can be done? ( 28447970 )
2017
38
Mesh penetrating the cecum and bladder following inguinal hernia surgery: a case report. ( 28903762 )
2017
39
Diagnostic Laparoscopy as Decision Tool for Re-recurrent Inguinal Hernia Treatment Following Open Anterior and Laparo-Endoscopic Posterior Repair. ( 28507989 )
2017
40
A comparison of preoperative and postoperative testicular volume and blood flow in patients with inguinal hernia, hydrocele, and cord cyst: A prospective cohort study. ( 28523038 )
2017
41
Persistent Mullerian Duct Syndrome Presenting in an Incarcerated Recurrent Inguinal Hernia with Hydrocele. ( 28331809 )
2017
42
Rives Technique for the Primary Larger Inguinal Hernia Repair: A Prospective Study of 1000 Repairs. ( 28484818 )
2017
43
Trends of inguinal hernia repairs performed for recurrence in the United States. ( 28923698 )
2017
44
Explaining variation in ventral and inguinal hernia repair outcomes: A population-based analysis. ( 28528663 )
2017
45
Reduction of Inguinal Hernia Ureteral Entrapment. ( 28532750 )
2017
46
Inguinal hernia surgery-A minor surgery that can cause major pain. ( 29913940 )
2017
47
Approach to inguinal hernia in high-risk geriatric patients: Should it be elective or emergent? ( 28467578 )
2017
48
Protective multimodal analgesia with etoricoxib and spinal anesthesia in inguinal hernia repair: a randomized controlled trial. ( 28455600 )
2017
49
Caution! The potential overestimated effect of prophylactic alpha-blockade for the prevention of urinary retention following primary inguinal hernia repair in a meta-analysis of randomized controlled trials. ( 28468725 )
2017
50
A systematic review and meta-analysis concerning single-site laparoscopic percutaneous extraperitoneal closure for pediatric inguinal hernia and hydrocele. ( 28389795 )
2017
Sources

Variations for Inguinal Hernia

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ClinVar genetic disease variations for Inguinal Hernia:

6
(show all 14)
# Gene Variation Type Significance SNP ID Assembly Location
1 NF1 NM_000267.3(NF1): c.7419G> A (p.Trp2473Ter) single nucleotide variant Pathogenic rs863224493 GRCh37 Chromosome 17, 29679299: 29679299
2 NF1 NM_000267.3(NF1): c.7419G> A (p.Trp2473Ter) single nucleotide variant Pathogenic rs863224493 GRCh38 Chromosome 17, 31352281: 31352281
3 46;XY;t(4;14)(p15.32;q32.1)dn Translocation Uncertain significance
4 46;XY;t(1;5)(p35.3;q31.3)dn Translocation Pathogenic
5 46;XY;t(3;10)(p26.3;q26.3)dn Translocation Pathogenic
6 46;XY;t(1;3)(p22;q21)dn Translocation Uncertain significance
7 46;XY;inv(6)(p22q13)dn inversion Pathogenic
8 FBN1 NM_000138.4(FBN1): c.840_843delTGAA (p.Asn280Lysfs) deletion Pathogenic rs1057518909 GRCh37 Chromosome 15, 48826296: 48826299
9 FBN1 NM_000138.4(FBN1): c.840_843delTGAA (p.Asn280Lysfs) deletion Pathogenic rs1057518909 GRCh38 Chromosome 15, 48534099: 48534102
10 ELN NM_001278939.1(ELN): c.898A> T (p.Thr300Ser) single nucleotide variant Uncertain significance rs766735416 GRCh37 Chromosome 7, 73466262: 73466262
11 ELN NM_001278939.1(ELN): c.898A> T (p.Thr300Ser) single nucleotide variant Uncertain significance rs766735416 GRCh38 Chromosome 7, 74051932: 74051932
12 COL5A1 NM_000093.4(COL5A1): c.608G> T (p.Gly203Val) single nucleotide variant Likely pathogenic GRCh37 Chromosome 9, 137593133: 137593133
13 COL5A1 NM_000093.4(COL5A1): c.608G> T (p.Gly203Val) single nucleotide variant Likely pathogenic GRCh38 Chromosome 9, 134701287: 134701287
14 subset of 29 genes:TBX1 GRCh37/hg19 22q11.21(chr22: 18894835-20311763) copy number loss Pathogenic GRCh37 Chromosome 22, 18894835: 20311763
Sources

Expression for Inguinal Hernia

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Search GEO for disease gene expression data for Inguinal Hernia.
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Pathways for Inguinal Hernia

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Pathways related to Inguinal Hernia according to GeneCards Suite gene sharing:

(show all 24)
# Super pathways Score Top Affiliating Genes
1
Integrin Pathway 64
Show member pathways
 13.29 EFEMP1 ELN FBN1 ITGA3 MMP1 MMP13
2
Phospholipase-C Pathway 64
Show member pathways
 12.93 EFEMP1 ELN FBN1 IL6 ITGA3 TIMP1
3
Pathways in cancer 37
12.71 AR IL6 ITGA3 MMP1 MMP2 MMP9
4
IL-17 Family Signaling Pathways 65
Show member pathways
 12.22 IL6 MMP1 MMP13 MMP9
5
Colorectal Cancer Metastasis 64
12.08 IL6 MMP1 MMP2 MMP9
6
Degradation of the extracellular matrix 66
Show member pathways
 11.98 EFEMP1 ELN FBN1 ITGA3 MMP1 MMP13
7
Interleukin-4 and 13 signaling 66
11.89 IL6 MMP1 MMP2 MMP9 TIMP1
8
Matrix Metalloproteinases 1
Show member pathways
 11.73 MMP1 MMP13 MMP2 MMP9 TIMP1 TIMP2
9
Angiogenesis (CST) 4
11.72 MMP13 MMP2 MMP9 TIMP1 TIMP2
10
Regulation of Wnt-mediated beta catenin signaling and target gene transcription 1
11.68 AR MMP2 MMP9
11
Bladder cancer 37 1
11.64 MMP1 MMP2 MMP9
12
Elastic fibre formation 66
Show member pathways
 11.64 EFEMP1 ELN FBN1
13
AGE/RAGE pathway 1
11.58 MMP13 MMP2 MMP9
14
LPA receptor mediated events 1
11.56 IL6 MMP2 MMP9
15
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.56 IL6 MMP1 MMP2 MMP9
16
Lung fibrosis 1
11.52 ELN IL6 MMP2 MMP9 TIMP1
17
ATF-2 transcription factor network 1
11.48 IL6 MMP2 NF1
18
amb2 Integrin signaling 1
11.39 IL6 MMP2 MMP9
19
Heart Development 1
11.36 GATA6 TBX1 TBX2
20
Validated transcriptional targets of AP1 family members Fra1 and Fra2 1
11.24 IL6 MMP1 MMP2 MMP9
21
Cell adhesion_ECM remodeling 22
11.22 MMP1 MMP13 MMP2 MMP9 TIMP1 TIMP2
22
Cell adhesion_Cell-matrix glycoconjugates 22
11.14 ELN ITGA3 MMP1 MMP9 TIMP2
23
IL1 and megakaryocytes in obesity 1
11.05 MMP9 TIMP1 TIMP2
24
Syndecan-1-mediated signaling events 1
10.85 MMP1 MMP9
Sources

GO Terms for Inguinal Hernia

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Cellular components related to Inguinal Hernia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.76 EFEMP1 FBN1 IL6 MMP13 MMP2 MMP9
2 extracellular region GO:0005576 9.73 ADAMTS6 EFEMP1 ELN FBN1 IL6 MMP1
3 extracellular matrix GO:0031012 9.28 EFEMP1 ELN FBN1 MMP1 MMP13 MMP2

Biological processes related to Inguinal Hernia according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.93 AR IL6 TBX1 TBX2 TBX3 TIMP1
2 cytokine-mediated signaling pathway GO:0019221 9.88 IL6 MMP1 MMP2 MMP9 TIMP1
3 positive regulation of MAPK cascade GO:0043410 9.83 AR IL6 TBX1 TIMP2
4 outflow tract morphogenesis GO:0003151 9.73 TBX1 TBX2 TBX3
5 heart morphogenesis GO:0003007 9.72 TBX1 TBX2 TBX3
6 extracellular matrix organization GO:0030198 9.72 ELN FBN1 ITGA3 MMP9 NF1
7 heart development GO:0007507 9.63 ADAMTS6 FBN1 GATA6 ITGA3 NF1 TBX1
8 aorta morphogenesis GO:0035909 9.6 TBX1 TBX2
9 embryonic eye morphogenesis GO:0048048 9.59 EFEMP1 FBN1
10 negative regulation of membrane protein ectodomain proteolysis GO:0051045 9.58 TIMP1 TIMP2
11 positive regulation of adenylate cyclase activity GO:0045762 9.58 NF1 TIMP2
12 endodermal cell differentiation GO:0035987 9.58 GATA6 MMP2 MMP9
13 animal organ formation GO:0048645 9.57 AR GATA6
14 collagen catabolic process GO:0030574 9.56 MMP1 MMP13 MMP2 MMP9
15 outflow tract septum morphogenesis GO:0003148 9.54 GATA6 TBX1 TBX2
16 post-embryonic eye morphogenesis GO:0048050 9.51 EFEMP1 FBN1
17 cellular protein metabolic process GO:0044267 9.5 FBN1 GATA6 IL6 MMP1 MMP13 MMP2
18 negative regulation of metallopeptidase activity GO:1905049 9.49 TIMP1 TIMP2
19 mammary placode formation GO:0060596 9.43 TBX2 TBX3
20 extracellular matrix disassembly GO:0022617 9.23 ELN FBN1 MMP1 MMP13 MMP2 MMP9
21 positive regulation of transcription, DNA-templated GO:0045893 10.01 AR EBF2 GATA6 IL6 TBX1 TBX3
22 negative regulation of apoptotic process GO:0043066 10 GATA6 IL6 MMP9 TBX3 TIMP1

Molecular functions related to Inguinal Hernia according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 peptidase activity GO:0008233 9.88 ADAMTS6 MMP1 MMP13 MMP2 MMP9
2 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.8 AR EBF2 GATA6 TBX2 TBX3
3 serine-type endopeptidase activity GO:0004252 9.76 MMP1 MMP13 MMP2 MMP9
4 collagen binding GO:0005518 9.61 ITGA3 MMP13 MMP9
5 protease binding GO:0002020 9.56 ITGA3 TIMP1 TIMP2 TTN
6 zinc ion binding GO:0008270 9.56 AR GATA6 MMP1 MMP13 MMP2 MMP9
7 metallopeptidase activity GO:0008237 9.55 ADAMTS6 MMP1 MMP13 MMP2 MMP9
8 RNA polymerase II transcription factor binding GO:0001085 9.54 AR GATA6 TBX3
9 metalloendopeptidase inhibitor activity GO:0008191 9.49 TIMP1 TIMP2
10 metalloendopeptidase activity GO:0004222 9.02 ADAMTS6 MMP1 MMP13 MMP2 MMP9
11 metal ion binding GO:0046872 10.1 ADAMTS6 AR EBF2 GATA6 ITGA3 MMP1
Sources

Sources for Inguinal Hernia

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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