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MCID: ING001
MIFTS: 59

Inguinal Hernia

Categories: Gastrointestinal diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Inguinal Hernia

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MalaCards integrated aliases for Inguinal Hernia:

Name: Inguinal Hernia 12 73 29 6 15 32
Hernia, Inguinal 44
Inguinal Hernias 15
Hernia Inguinal 54

Classifications:

MalaCards categories:
Anatomical: Gastrointestinal diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:0060320
ICD9CM 34 550
MeSH 44 D006552
SNOMED-CT 67 155738001 196800008
UMLS 70 C0019294 C0019295 C0019296
Sources

Summaries for Inguinal Hernia

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Disease Ontology : 12 An intestinal disease characterized by a protrusion of abdominal cavity contests through the inguinal canal.

MalaCards based summary : Inguinal Hernia, also known as hernia, inguinal, is related to cutis laxa, autosomal recessive, type ia and arterial tortuosity syndrome. An important gene associated with Inguinal Hernia is EFEMP1 (EGF Containing Fibulin Extracellular Matrix Protein 1), and among its related pathways/superpathways are Integrin Pathway and Phospholipase-C Pathway. The drugs Ketorolac and Caffeine have been mentioned in the context of this disorder. Affiliated tissues include testis, colon and skin, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : 73 An inguinal hernia is a protrusion of abdominal-cavity contents through the inguinal canal. Symptoms are... more...

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Related Diseases for Inguinal Hernia

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Diseases related to Inguinal Hernia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 627)
# Related Disease Score Top Affiliating Genes
1 cutis laxa, autosomal recessive, type ia 32.6 LOXL1 FBN1 FBLN5 ELN
2 arterial tortuosity syndrome 32.5 FBN1 FBLN5 ELN
3 autosomal recessive cutis laxa type i 32.4 FBN1 FBLN5 ELN
4 familial thoracic aortic aneurysm and aortic dissection 32.3 FBN1 ELN COL5A1
5 cutis laxa 32.1 MMP9 MMP2 MMP1 LOXL1 FBN1 FBLN5
6 aneurysm 31.5 NF1 FBN1 FBLN5 ELN
7 diverticulitis 31.4 MMP9 MMP13 IL6
8 aortic aneurysm 31.4 MMP9 MMP2 MMP13 IL6 FBN1 FBLN5
9 bladder diverticulum 31.4 FBLN5 ELN EFEMP1
10 aortic aneurysm, familial abdominal, 1 31.3 TIMP2 MMP9 MMP2 MMP13 MMP1 IL6
11 bone inflammation disease 31.2 MMP9 MMP13 MMP1 IL6
12 varicose veins 31.1 TIMP2 MMP9 MMP2 MMP1 IL6 FBN1
13 pneumothorax 31.1 TIMP2 MMP9 MMP2 MMP1 FBN1 FBLN5
14 hydronephrosis 31.1 MMP9 IL6 FBN1
15 hypermobile ehlers-danlos syndrome 30.8 FBN1 EFEMP1 COL5A1
16 pulmonary disease, chronic obstructive 30.8 MMP9 MMP1 IL6 ELN
17 connective tissue disease 30.8 MMP13 IL6 FBN1 FBLN5 ELN COL5A1
18 neuroma 30.7 NF1 IL6 CALCA
19 heart disease 30.6 TIMP2 MMP9 MMP2 MMP1 IL6 FBN1
20 cerebral aneurysms 30.6 MMP2 ELN
21 gastrointestinal stromal tumor 30.6 WT1 NF1 MMP9 MMP2
22 venous insufficiency 30.6 MMP9 MMP1 ELN
23 brittle bone disorder 30.6 MMP13 FBN1 ELN COL5A1 CALCA
24 chronic venous insufficiency 30.5 TIMP2 MMP9 MMP1
25 lymphangioleiomyomatosis 30.5 MMP9 MMP2 MMP1 ELN
26 exfoliation syndrome 30.5 MMP1 LOXL1 FBN1 ELN
27 aortic disease 30.5 MMP9 IL6 FBN1 ELN
28 gastric ulcer 30.5 MMP9 IL6 CALCA
29 pyelonephritis 30.5 MMP9 IL6 CALCA
30 osteoarthritis 30.5 MMP9 MMP13 MMP1 IL6
31 synovitis 30.5 TIMP2 MMP9 MMP13 MMP1 IL6
32 williams-beuren syndrome 30.4 MMP9 MMP2 FBN1 ELN CALCA
33 myopia 30.4 TIMP2 MMP2 MMP1 FBN1 CEMIP2
34 marfan syndrome 30.4 MMP2 MMP1 LOXL1 FBN1 ELN COL5A1
35 osteochondrodysplasia 30.4 NF1 MMP13 FBN1 ELN COL5A1 CALCA
36 orthostatic intolerance 30.4 FBN1 ELN COL5A1
37 osteogenic sarcoma 30.4 WT1 MMP9 MMP2 IL6
38 diaphragmatic hernia, congenital 30.3 WT1 FBN1 ELN
39 ewing sarcoma 30.2 WT1 NF1 MMP9 IL6
40 arthrogryposis multiplex with deafness, inguinal hernias, and early death 11.4
41 lambert syndrome 11.4
42 persistent mullerian duct syndrome 11.4
43 spondylocostal dysostosis 3, autosomal recessive 11.3
44 mucopolysaccharidosis, type ii 11.2
45 aarskog-scott syndrome 11.2
46 opitz-kaveggia syndrome 11.2
47 achondrogenesis, type ib 11.2
48 marfanoid habitus-inguinal hernia-advanced bone age syndrome 11.2
49 pseudomyxoma peritonei 11.1
50 chronic pain 11.1

Graphical network of the top 20 diseases related to Inguinal Hernia:



Diseases related to Inguinal Hernia
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Symptoms & Phenotypes for Inguinal Hernia

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GenomeRNAi Phenotypes related to Inguinal Hernia according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00221-A-1 9.55 NF1
2 Decreased viability GR00221-A-2 9.55 NF1
3 Decreased viability GR00221-A-4 9.55 NF1
4 Decreased viability GR00240-S-1 9.55 ACTL6A
5 Decreased viability GR00249-S 9.55 ACTL6A EBF2 NF1
6 Decreased viability GR00381-A-1 9.55 CALCA WT1
7 Decreased viability GR00386-A-1 9.55 ELN LOXL1 NF1
8 Decreased viability GR00402-S-2 9.55 EBF2 ELN FBLN5 FBN1 LOXL1
9 Decreased sensitivity to paclitaxel GR00112-A-0 8.96 NF1 WT1

MGI Mouse Phenotypes related to Inguinal Hernia:

46 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.39 ADAMTS6 AR COL5A1 EBF2 EFEMP1 FBLN5
2 growth/size/body region MP:0005378 10.35 ADAMTS6 AR COL5A1 EBF2 EFEMP1 FBLN5
3 homeostasis/metabolism MP:0005376 10.28 ADAMTS6 AR EFEMP1 FBLN5 FBN1 IL6
4 hematopoietic system MP:0005397 10.23 ACTL6A ADAMTS6 AR EBF2 EFEMP1 FBN1
5 immune system MP:0005387 10.18 ACTL6A ADAMTS6 AR EFEMP1 FBN1 IL6
6 integument MP:0010771 10.07 AR COL5A1 EFEMP1 FBLN5 FBN1 IL6
7 craniofacial MP:0005382 10.04 ADAMTS6 AR EBF2 FBLN5 FBN1 MMP2
8 muscle MP:0005369 9.91 AR EFEMP1 FBLN5 FBN1 IL6 MMP2
9 limbs/digits/tail MP:0005371 9.87 ADAMTS6 AR EBF2 FBN1 MMP13 MMP9
10 neoplasm MP:0002006 9.76 AR FBLN5 IL6 MMP1 MMP2 MMP9
11 respiratory system MP:0005388 9.61 EBF2 FBLN5 FBN1 IL6 LOXL1 MMP2
12 skeleton MP:0005390 9.32 ADAMTS6 AR EBF2 EFEMP1 FBN1 IL6
Sources

Drugs & Therapeutics for Inguinal Hernia

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Drugs for Inguinal Hernia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 143)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
2
Caffeine Approved Phase 4 58-08-2 2519
3
Cefazolin Approved Phase 4 25953-19-9 656510 33255
4
Acetaminophen Approved Phase 4 103-90-2 1983
5
Tizanidine Approved, Investigational Phase 4 51322-75-9 5487
6
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
7
Bupivacaine Approved, Investigational Phase 4 38396-39-3, 2180-92-9 2474
8
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
9
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
10
Ibuprofen Approved Phase 4 15687-27-1 3672
11
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
12
Chloroprocaine Approved Phase 4 133-16-4 8612
13
Procaine Approved, Investigational, Vet_approved Phase 4 59-46-1 4914
14
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
15
tannic acid Approved Phase 4 1401-55-4
16
Benzocaine Approved, Investigational Phase 4 1994-09-7, 94-09-7 2337
17
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
18
Prilocaine Approved Phase 4 721-50-6 4906
19
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
20
Levobupivacaine Approved, Investigational Phase 4 27262-47-1 92253
21
Clonidine Approved Phase 4 4205-90-7 2803
22
Tamsulosin Approved, Investigational Phase 4 106133-20-4 129211
23
Glutamic acid Approved, Nutraceutical Phase 4 56-86-0 33032
24
Imidacloprid Vet_approved Phase 4 105827-78-9 86418
25 Central Nervous System Stimulants Phase 4
26 Phosphodiesterase Inhibitors Phase 4
27 Gentamicins Phase 4
28 Anti-Infective Agents Phase 4
29 Antirheumatic Agents Phase 4
30 Gastrointestinal Agents Phase 4
31 Anti-Inflammatory Agents Phase 4
32 Anti-Inflammatory Agents, Non-Steroidal Phase 4
33 Analgesics, Non-Narcotic Phase 4
34 Analgesics Phase 4
35 Cyclooxygenase Inhibitors Phase 4
36 Antipyretics Phase 4
37 Parasympatholytics Phase 4
38 Sodium Channel Blockers Phase 4
39 Anti-Arrhythmia Agents Phase 4
40 Anesthetics, Local Phase 4
41 Diuretics, Potassium Sparing Phase 4
42 Antiemetics Phase 4
43 Hormones Phase 4
44 Hormone Antagonists Phase 4
45 Antineoplastic Agents, Hormonal Phase 4
46 glucocorticoids Phase 4
47 Analgesics, Opioid Phase 4
48 Respiratory System Agents Phase 4
49 Anti-Asthmatic Agents Phase 4
50 Adrenergic beta-Agonists Phase 4

Interventional clinical trials:

(show top 50) (show all 374)
# Name Status NCT ID Phase Drugs
1 Rebound Hernia Repair Device Trial Unknown status NCT00968773 Phase 4
2 Early Outcome of Inguinal Hernia Repair With Biomerix Surgical Mesh Using the Lichtenstein Technique Unknown status NCT00924755 Phase 4
3 Chronic Significant Pain and Functional Outcome After Laparoscopic Versus Open Groin Hernia Mesh Repair: Design of a Randomized Controlled Clinical Trial Unknown status NCT00625534 Phase 4
4 Controlled Release of Oxycodone 10 mg In Pre-Medication For The Post Operative Analgesia In Elective Laparoscopic Bilateral Inguinal Hernia And Elective Laparoscopic Cholecystectomy : Prospective Double Blind, Randomized, Placebo-Controlled Study Unknown status NCT00480142 Phase 4 Oxycodone 10 mg
5 The Effect of Different Doses of Ketamine on Tracheal Intubating Conditions Using Low Dose Rocuronium in Children Unknown status NCT02646709 Phase 4 Rocuronium;ketamine 1;ketamine 1.5;ketamine 2
6 Does Ultrasound-guided Ilioinguinal-iliohypogastric Block Improve Postoperative Pain Outcome After Unilateral Inguinal Hernia Repair? Unknown status NCT01326039 Phase 4 bupivacaine;saline
7 The Impact of Perioperative Gabapentin on Chronic Groin Pain After Inguinal Hernia Repair Unknown status NCT02419443 Phase 4 Gabapentin;Placebo
8 Effects of Transverse Abdominis Plane Block Guided by Ultrasound on the Postoperative Analgesia and Quality of Lives Among the Patients Undergo Inguinal Hernia Repair Unknown status NCT02292095 Phase 4
9 Does the Preoperative Midazolam Dose Affect Postoperative Pain? - a Multicentric Randomized Controlled Trial in Ambulatory Surgery Unknown status NCT03534895 Phase 4 Midazolam Injectable Solution;Postoperative analgesia;Rescue analgesia;Wound infiltration;Analgesia at home
10 Multicentre Randomised Controled Trial Comparing the Effect of a New Self-gripping Lightweight Polyester Mesh and a Normal Sutured Lightweight Polyester Mesh on the Incidence of Chronic Inguinodynia in Lichtenstein Hernioplasty. Unknown status NCT01830452 Phase 4
11 Is Topical Antibiotic Prophylaxis Effective in Lichtenstein Hernia Repair: a Comparison Study Completed NCT01273818 Phase 4 Gentamicin and cefazolin;Cefazolin;Gentamicin
12 Early and Late Results of Transinguinal Preperitoneal Patch Repair Versus Anterior Pre-Trasversalis Mesh Repair. A Randomised Study Completed NCT01350830 Phase 4
13 Investigation of the Effectiveness of Tizanidine on Pain After Herniorrhaphy Completed NCT02016443 Phase 4 Tizanidine;Placebo
14 A Randomized, Phase 4 Study of the Efficacy, Safety, and Pharmacokinetics of Bupivacaine Administered as Liposomal Bupivacaine or Continuous Infusion Via Elastomeric Pump Following Unilateral Open Inguinal Herniorrhaphy Completed NCT04102267 Phase 4 Bupivacaine liposome injectable suspension;Bupivacaine HCl without epinephrine via continuous infusion
15 A Multicenter Prospective Randomized Trial on Chronic Pain After Inguinal Hernia Repair Using a Selfgrip-mesh Completed NCT00820131 Phase 4
16 Prospective, Randomized, Controlled, Third-Party Blinded Multicenter Evaluation of Strattice/LTM in the Repair of Inguinal Hernias Completed NCT00681291 Phase 4
17 Single Dose Antibiotic Prophylaxis in Lihtenstein Repair for Primary Inguinal Hernias Completed NCT01264003 Phase 4 sefazolin
18 Prospective Randomized, Double-blind, Controlled Trial Comparing Lichtenstein's Repair of Inguinal Hernia With Polypropylene Mesh Versus Surgisis ES Soft Tissue Graft Completed NCT00614419 Phase 4
19 ProGrip Mesh Repair Versus Lichtenstein Mesh Repair: a Comparative Randomized Study in Primary Inguinal Hernia Completed NCT00827944 Phase 4
20 Prolene Hernia System, Lichtenstein Mesh, and Plug-and-Patch for Primary Inguinal Hernia Repair - Three Year Outcome of a Prospective Randomised Controlled Trial Completed NCT00580177 Phase 4
21 Comparative Study of Safety and Efficacy of Heavyweight and Partially Absorbable Mesh in Inguinal Hernia Repair Completed NCT01877122 Phase 4
22 Comparing Non-fixation of Mesh to Mesh Fixation in Laparoscopic Total Extraperitoneal Inguinal Hernia Repair Under Spinal Anesthesia- A Randomized Controlled Trial Completed NCT01117337 Phase 4
23 Analgesic Efficacy of Ultrasound-guided Inguinal Field Block (Genitofemoral, Iliohypogastric and Ilioinguinal Nerve Block) for Inguinal Hernia Surgery. Completed NCT01521481 Phase 4
24 Comparison of Postoperative Analgesic Effects of Transversus Abdominis Plane Block and Quadratus Lumborum Block Type 2 Completed NCT03126084 Phase 4 Acetaminophen;0.25% Bupivacaine;0.5% Bupivacaine+Glucose;Tramadol HCl;0.25% Bupivacaine
25 Comparative Efficacy of Intravenous Acetaminophen vs. Oral Acetaminophen in Ambulatory Surgery Completed NCT03558555 Phase 4 Acetaminophen IV Soln;Oral Acetaminophen;Placebo Pills;Saline
26 A Multi-site Randomised Controlled Trial Comparing Regional and General Anaesthesia for Effects on Neurodevelopmental Outcome and Apnoea in Infants Completed NCT00756600 Phase 4 Regional Anesthesia;General Anesthesia
27 Prospective, Controlled, Randomized Study to Evaluate Pain and Further Disabling Complications in Patients Undergoing Lichtenstein Technique for Primary Inguinal Hernia Repair by Fixing the Mesh With Fibrin Sealant Versus Sutures Completed NCT00306839 Phase 4
28 The Comparison of Two Different Doses of Morphine Added to Spinal Bupivacaine for Inguinal Hernia Repair. Completed NCT02001948 Phase 4 intrathecal morphine 0.1 mg combined with intrathecal heavy bupivacaine 7.5 mg;intrathecal morphine 0.4 mg combined with intrathecal heavy bupivacaine 7.5 mg;intravenous cannulation and premedication
29 Selective Subarachnoid Anesthesia. Comparison of Hyperbaric Bupivacaine and Hyperbaric Prilocaine in Knee Arthroscopy and Inguinal Hernia Repair in Ambulatory Surgery Completed NCT01921231 Phase 4 Hyperbaric Prilocaine 1%;Hyperbaric bupivacaine 0.5%
30 Lichtenstein's Repair of Inguinal Hernia With Polypropylene Mesh Versus Infinit® PTFE Mesh, a Prospective Randomized, Double-blind, Controlled Trial Completed NCT01141335 Phase 4
31 Comparision of the Use in Marcaine and Chloroprocaine in Rachianesthesia for the Surgical Correction of Inguinal Hernia. Completed NCT02049255 Phase 4 Chloroprocaine;Marcaine
32 Evaluation of Dexamethasone Added to the Usual Infiltration With Bupivacaine in Inguinal Hernia Repair Mesh Completed NCT03007927 Phase 4 Bupivacaine-Dexamethasone;Bupivacaine- physiological solution
33 A Randomized, Double-blinded, Placebo-controlled Trial of the Effects of Infusing Local Anesthesia on Post-operative Pain During Laparoscopic Inguinal Hernia Repair Completed NCT02055053 Phase 4 0.5% Bupivicaine
34 Preoperative Administration of Tamsulosin for Prevention of Post Operative Urinary Retention in Males Undergoing Elective Inguinal Hernia Repair Completed NCT02958878 Phase 4 Tamsulosin;Placebo Oral Capsule
35 Determination of the Minimum Local Anesthetic Dose (MLAD) of Spinal Chloroprocaine for Inguinal Herniorrhaphy in Ambulatory Surgery Completed NCT03805503 Phase 4 Chloroprocaine 1% Injectable Solution
36 Evaluation of Postoperative Pain Following Laparoscopic Hernia Repair: A Prospective, Randomized Comparison to Evaluate the Incidence of Post-operative Pain Associated With Absorbable Fixation (AbsorbaTack) vs Conventional Fixation (ProTack) Following Laparoscopic Hernia Repair Completed NCT00749268 Phase 4
37 THE EFFECT OF DIFFERENT INDUCTION TECHNIQUES ON POSTOPERATIVE PAIN AND AGITATION IN CHILDREN Completed NCT02110745 Phase 4 Sevofluorane;Propofol
38 ZIH Study : Comparison of Oral Zaldiar (Combination of Paracetamol and Tramadol) With Intravenous Paracetamol and Tramadol for Postoperative Analgesia After Inguinal Hernia Repair Completed NCT02389361 Phase 4 Zaldiar;Paracetamol-Tramadol
39 A Comparison of the Recovery Profiles of Bupivacaine or Bupivacaine Mixed With Lidocaine Spinal Anesthesia and Local Infiltration Anesthesia for Outpatient Herniorrhaphy Completed NCT01548794 Phase 4
40 The Efficacy of Transversus Abdominis Plane Block Versus Placebo Versus Local Infiltration in Patients Undergoing Groin Hernia Repair in Day Case Surgery. Completed NCT01052285 Phase 4
41 Evaluation of the Analgesic Effect of Tramadol Wound Infiltration in Children Under Inguinal Hernioplasty. A Double-blind, Randomized Study. Completed NCT01943760 Phase 4 tramadol;0.9% saline
42 Randomized, Quadruple Blinded, Placebo Controlled, Multi-centered Trial Investigating Prophylactic Tamsulosin in Prevention of Postoperative Urinary Retention in Men After Endoscopic Total Extraperitoneal Inguinal Hernia Repair Recruiting NCT04491526 Phase 4 TAMSULOSIN Mepha Ret Depocaps 0.4 mg;Control Intervention
43 The Effect of Local Anesthetic and Clonidine on the Cutaneous Silent Period During and After Spinal Anesthesia Active, not recruiting NCT03121261 Phase 4 levobupivacaine;clonidine
44 The Use of Tamsulosin to Prevent Postoperative Urinary Retention in Laparoscopic Inguinal Hernia Repair: A Randomized Double-Blind Placebo-Controlled Study Terminated NCT04434378 Phase 4 Tamsulosin;Placebo
45 Pre-emptive Intravenous Analgesia for Elective Inguinal Hernia Repair: Prospective Randomized Double-blinded Placebo Controlled Comparison of Lornoxicam and Paracetamol Unknown status NCT01069055 Phase 3 Intravenous lornoxicam;Intravenous paracetamol
46 Use of Acellular Dermal in the Incarcerated Inguinal Hernia Tension-free Reconstructions Unknown status NCT02469142 Phase 2, Phase 3
47 Improving Patient Outcomes With Inguinal Hernioplasty - a Randomized Controlled Trial of Local Anaesthesia Versus Local Anaesthesia and Conscious Sedation Unknown status NCT02444260 Phase 3 Midazolam;Intravenous Normal Saline;Bupivocaine;Lignocaine HCl
48 The Prospective Randomized Comparison of the Onset Time of Rocuronium in Patients Undergoing Emergency and Elective Surgery Unknown status NCT02634255 Phase 3 Rocuronium elective surgery;Rocuronium emergency surgery;Propofol;Fentanyl
49 Efficacy of Pre-operative Oral Pregabalin in Ambulatory Inguinal Hernia Repair for Post Operative Pain Unknown status NCT01450345 Phase 3 Pregabalin
50 Laparoscopic-assisted Transversus Abdominis Plane (TAP) Block for Laparoscopic Total Extra Peritoneal (TEP) Inguinal Hernia Repair: a Prospective, Double-blinded, Randomized, Clinical Trial Unknown status NCT02632136 Phase 3 TAP Block Group;Peri-Portal Block Group

Search NIH Clinical Center for Inguinal Hernia

Cochrane evidence based reviews: hernia, inguinal

Sources

Genetic Tests for Inguinal Hernia

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Genetic tests related to Inguinal Hernia:

# Genetic test Affiliating Genes
1 Inguinal Hernia 29
Sources

Anatomical Context for Inguinal Hernia

About this section

MalaCards organs/tissues related to Inguinal Hernia:

40
Testis, Colon, Skin, Appendix, Uterus, Kidney, Ovary
Sources

Publications for Inguinal Hernia

About this section

Articles related to Inguinal Hernia:

(show top 50) (show all 12116)
# Title Authors PMID Year
1
Preoperative oral granisetron for the prevention of vomiting following paediatric surgery. 54 61
11903942 2002
2
A role for the collagen I/III and MMP-1/-13 genes in primary inguinal hernia? 54 61
11872152 2002
3
Prophylactic therapy with combined granisetron and dexamethasone for the prevention of post-operative vomiting in children. 54 61
10434165 1999
4
Granisetron reduces post-operative vomiting in children: a dose-ranging study. 54 61
10084103 1999
5
Synthesis of type I and III collagen, expression of fibronectin and matrix metalloproteinases-1 and -13 in hernial sac of patients with inguinal hernia. 61 54
11341610 1999
6
Upper and lower urinary tract obstruction secondary to inguinoscrotal hernia containing bladder and prostate gland. 61
33665127 2021
7
Performance of the Emergency Surgery Score (ESS) Across Different Emergency General Surgery Procedures. 61
33429224 2021
8
Sonographic appearance of a large lipoma of the spermatic cord presenting clinically as an inguinoscrotal hernia. 61
32914871 2021
9
Well-differentiated liposarcoma of the spermatic cord: A case report. 61
33643848 2021
10
Efficiency of Increasing Prospective Resident Entrustment in the Operating Room. 61
33460968 2021
11
Analysing the Operative Experience of Paediatric Surgical Trainees in Sub-Saharan Africa Using a Web-Based Logbook. 61
33289874 2021
12
Carotid Revascularization Improves Cognition in Patients With Asymptomatic Carotid Artery Stenosis and Cognitive Decline. Greater Improvement in Younger Patients With More Disordered Neuropsychological Performance. 61
33461024 2021
13
How Much is Enough? Public Perception of Minimum Surgeon Volumes. 61
33796922 2021
14
Amyand's hernia: presumptive diagnosis by CT and literature review. 61
33613803 2021
15
Robotic-assisted laparoscopic inguinal hernia repair after previous transabdominal prostatectomy. 61
33796906 2021
16
Postoperative outcomes following inguinal hernia repair in inflammatory bowel disease patients compared to matched controls. 61
32956182 2021
17
Ultrasound-guided transversalis fascia plane block versus transmuscular quadratus lumborum block for post-operative analgesia in inguinal hernia repair. 61
33785672 2021
18
Laparoscopic repair of inguinal hernia in a patient with a ventriculoperitoneal shunt: A case report. 61
32856416 2021
19
Persistent scrotal swelling after laparoscopic inguinal hernia repair: "Omentaloma of the scrotum". 61
32776466 2021
20
Single-incision laparoscopic totally extraperitoneal inguinal hernia repair with tumescent local anesthesia: report of more than 2000 procedures at a day-surgery clinic. 61
32939603 2021
21
Drainage decreases the seroma incidence in laparoscopic transabdominal preperitoneal (TAPP) hernia repair for large inguinoscrotal hernias. 61
33191072 2021
22
Adaptation and validation of the Carolinas Comfort Scale: a questionnaire-based cross-sectional study. 61
33782789 2021
23
The most commonly injured nerves at surgery: A comprehensive review. 61
33090551 2021
24
Study on pathogenic genes of dwarfism disease by next-generation sequencing. 61
33728303 2021
25
The Comparison of Balloon and Camera Dissection of the Preperitoneal Space in Totally Extraperitoneal Repair Hernia Repair. Our Initial Experience! 61
33710918 2021
26
Instructional methods of attendings as exhibited during intraoperative takeovers: A pilot study. 61
33781584 2021
27
Spontaneous colo-vesical and colo-cutaneous fistula complicating a sigmoid diverticulitis: A case report. 61
33592411 2021
28
Mesh in Elective Hernia Repair: 10-Year Experience with over 6,000 Patients. 61
33746110 2021
29
Consensus exercise identifying priorities for research in the field of general surgery of childhood in the UK. 61
33728468 2021
30
Is Minimally Invasive Repair the New Gold Standard for Primary Unilateral Inguinal Hernias? Results of an International Survey of Surgeons. 61
33685253 2021
31
Rare Intraoperative and Postoperative Complications After Transabdominal Laparoscopic Hernia Repair: Results from the Multicenter Wall Hernia Group Registry. 61
32808863 2021
32
Abdominal Extension of Fournier Gangrene From Undiagnosed Crohn's Disease: A Case Report. 61
33742649 2021
33
Ultrasound-guided microwave ablation in the treatment of inguinal neuralgia. 61
33000286 2021
34
Testicular torsion in the medicolegal perspective: Why is the diagnosis missing? 61
33630295 2021
35
Atypical Clinical Presentation of Persistent Müllerian Duct Syndrome in Siblings. 61
33691324 2021
36
Myopericytoma in right inguinal region: A rare case report from Nepal. 61
33774449 2021
37
Inguinal hernia of the distal ureter causing hydronephrosis: A rare case. 61
33437644 2021
38
Limited surface examination to evaluate potential teratogens in a resource-limited setting. 61
33779067 2021
39
Inguinal hernia plugs mimicking abdominal wall invasion of bladder cancer - a potential imaging pitfall. 61
33795165 2021
40
Association of anesthesia type with prolonged postoperative intubation in neonates undergoing inguinal hernia repair. 61
32499596 2021
41
Contralateral exploration and repair of occult inguinal hernias during laparoscopic inguinal hernia repair: systematic review and Markov decision process. 61
33688950 2021
42
Trans-gastric inguinal hernia repair using pure natural orifice transluminal endoscopic surgery. 61
33468378 2021
43
Predictors of chronic pain after laparoscopic inguinal hernia repair. 61
32988621 2021
44
Inguinal hernia mesh is safe in 1720 patients. 61
33763744 2021
45
[Inguinal hernia in children: easily incarcerated]. 61
33793128 2021
46
Clinical and Cost Outcomes of Robot-Assisted Inguinal Hernia Repair: A Systematic Review. 61
33771676 2021
47
Re: 'Traumatic inguinal hernia: An uncommonly reported entity'. 61
33765874 2021
48
Meta-analysis of mesh-plug repair and Lichtenstein repair in the treatment of primary inguinal hernia. 61
33759110 2021
49
The inguinal hernia management in Costa Rica according to a survey between surgeons: result comparison with 2018 International Groin Hernia Guidelines. 61
33743667 2021
50
The Operative Time for Unilateral Inguinal Hernia Repair in Children Performed with Percutaneous Internal Ring Suturing (PIRS) or Open Approach Method. 61
33800993 2021
Sources

Variations for Inguinal Hernia

About this section

ClinVar genetic disease variations for Inguinal Hernia:

6 (show all 11)
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 FBN1 NM_000138.4(FBN1):c.840_843del (p.Asn280fs) Deletion Pathogenic 374115 rs1057518909 GRCh37: 15:48826296-48826299
GRCh38: 15:48534099-48534102
2 NF1 NM_000267.3(NF1):c.7419G>A (p.Trp2473Ter) SNV Pathogenic 216067 rs863224493 GRCh37: 17:29679299-29679299
GRCh38: 17:31352281-31352281
3 overlap with 29 genes GRCh37/hg19 22q11.21(chr22:18894835-20311763) copy number loss Pathogenic 523273 GRCh37: 22:18894835-20311763
GRCh38:
4 EFEMP1 NM_001039348.3(EFEMP1):c.320_324del (p.Met107fs) Deletion Pathogenic 691884 rs1572850869 GRCh37: 2:56144993-56144997
GRCh38: 2:55917858-55917862
5 EFEMP1 NM_001039348.3(EFEMP1):c.615T>A (p.Tyr205Ter) SNV Pathogenic 691885 rs765517862 GRCh37: 2:56108772-56108772
GRCh38: 2:55881637-55881637
6 CEMIP2 NM_013390.3(CEMIP2):c.1358G>A (p.Cys453Tyr) SNV Pathogenic 827846 GRCh37: 9:74349757-74349757
GRCh38: 9:71734841-71734841
7 CEMIP2 NM_013390.3(CEMIP2):c.3144G>A (p.Trp1048Ter) SNV Pathogenic 827847 GRCh37: 9:74319561-74319561
GRCh38: 9:71704645-71704645
8 ACTL6A NM_004301.5(ACTL6A):c.1129C>T (p.Arg377Trp) SNV Likely pathogenic 549661 rs868064163 GRCh37: 3:179304340-179304340
GRCh38: 3:179586552-179586552
9 COL5A1 NM_001278074.1(COL5A1):c.608G>T (p.Gly203Val) SNV Likely pathogenic 523328 rs1554781700 GRCh37: 9:137593133-137593133
GRCh38: 9:134701287-134701287
10 LSM1 NM_014462.3(LSM1):c.231+4A>C SNV Uncertain significance 623485 rs775468919 GRCh37: 8:38027316-38027316
GRCh38: 8:38169798-38169798
11 ELN NM_000501.4(ELN):c.898A>T (p.Thr300Ser) SNV Uncertain significance 523433 rs766735416 GRCh37: 7:73466262-73466262
GRCh38: 7:74051932-74051932
Sources

Expression for Inguinal Hernia

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Search GEO for disease gene expression data for Inguinal Hernia.
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Pathways for Inguinal Hernia

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Pathways related to Inguinal Hernia according to GeneCards Suite gene sharing:

(show all 24)
# Super pathways Score Top Affiliating Genes
1
Integrin Pathway 63
Show member pathways
 13.27 MMP9 MMP2 MMP13 MMP1 FBN1 ELN
2
Phospholipase-C Pathway 63
Show member pathways
 12.96 TIMP2 IL6 FBN1 ELN EFEMP1 COL5A1
3
Collagen chain trimerization 65
Show member pathways
 12.75 MMP9 MMP13 LOXL1 ELN COL5A1
4
Pathways in cancer 36
12.73 MMP9 MMP2 MMP1 IL6 AR
5
IL-17 Family Signaling Pathways 64
Show member pathways
 12.23 MMP9 MMP13 MMP1 IL6
6
Colorectal Cancer Metastasis 63
12.07 MMP9 MMP2 MMP1 IL6
7
Degradation of the extracellular matrix 65
Show member pathways
 12.02 TIMP2 MMP9 MMP2 MMP13 MMP1 LOXL1
8
Interleukin-4 and 13 signaling 65
11.84 MMP9 MMP2 MMP1 IL6
9
Matrix Metalloproteinases 1
Show member pathways
 11.72 TIMP2 MMP9 MMP2 MMP13 MMP1
10
Angiogenesis (CST) 4
11.71 TIMP2 MMP9 MMP2 MMP13
11
Regulation of Wnt-mediated beta catenin signaling and target gene transcription 1
11.68 MMP9 MMP2 AR
12
Bladder cancer 36 1
11.64 MMP9 MMP2 MMP1
13
AGE/RAGE pathway 1
11.57 MMP9 MMP2 MMP13
14
LPA receptor mediated events 1
11.56 MMP9 MMP2 IL6
15
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.53 MMP9 MMP2 MMP1 IL6
16
Elastic fibre formation 65
Show member pathways
 11.52 LOXL1 FBN1 FBLN5 ELN EFEMP1
17
ATF-2 transcription factor network 1
11.47 NF1 MMP2 IL6
18
amb2 Integrin signaling 1
11.39 MMP9 MMP2 IL6
19
Lung fibrosis 1
11.35 MMP9 MMP2 IL6 ELN CALCA
20
Transcription_Role of VDR in regulation of genes involved in osteoporosis 23
11.34 IL6 CALCA AR
21
Cell adhesion_Cell-matrix glycoconjugates 23
11.3 TIMP2 MMP9 MMP1 ELN
22
Validated transcriptional targets of AP1 family members Fra1 and Fra2 1
11.2 MMP9 MMP2 MMP1 IL6
23
Cell adhesion_ECM remodeling 23
11.14 TIMP2 MMP9 MMP2 MMP13 MMP1
24
G-protein signaling_Rap2B regulation pathway 23
10.87 TIMP2 IL6 FBN1 ELN EFEMP1 COL5A1
Sources

GO Terms for Inguinal Hernia

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Cellular components related to Inguinal Hernia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 10 TIMP2 MMP9 MMP2 MMP13 LOXL1 IL6
2 extracellular region GO:0005576 10 TIMP2 MMP9 MMP2 MMP13 MMP1 LOXL1
3 collagen-containing extracellular matrix GO:0062023 9.61 TIMP2 MMP9 MMP2 LOXL1 FBN1 FBLN5
4 basement membrane GO:0005604 9.54 LOXL1 FBN1 COL5A1
5 extracellular matrix GO:0031012 9.4 TIMP2 MMP9 MMP2 MMP13 MMP1 LOXL1
6 elastic fiber GO:0071953 9.32 FBLN5 ELN

Biological processes related to Inguinal Hernia according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.89 WT1 TIMP2 NF1 IL6 AR
2 heart development GO:0007507 9.84 WT1 NF1 FBN1 ADAMTS6
3 camera-type eye development GO:0043010 9.65 WT1 FBN1 EFEMP1
4 collagen fibril organization GO:0030199 9.63 NF1 LOXL1 COL5A1
5 cellular protein metabolic process GO:0044267 9.63 MMP2 MMP13 MMP1 IL6 FBN1 CALCA
6 embryo implantation GO:0007566 9.58 MMP9 MMP2 CALCA
7 collagen catabolic process GO:0030574 9.56 MMP9 MMP2 MMP13 MMP1
8 regulation of neuroinflammatory response GO:0150077 9.55 MMP9 IL6
9 response to amyloid-beta GO:1904645 9.54 MMP9 MMP2 MMP13
10 embryonic eye morphogenesis GO:0048048 9.52 FBN1 EFEMP1
11 positive regulation of adenylate cyclase activity GO:0045762 9.51 TIMP2 NF1
12 cellular response to UV-A GO:0071492 9.5 MMP9 MMP2 MMP1
13 post-embryonic eye morphogenesis GO:0048050 9.43 FBN1 EFEMP1
14 extracellular matrix organization GO:0030198 9.36 NF1 MMP9 MMP2 MMP13 MMP1 LOXL1
15 extracellular matrix disassembly GO:0022617 9.35 TIMP2 MMP9 MMP2 MMP13 MMP1

Molecular functions related to Inguinal Hernia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 metal ion binding GO:0046872 10.17 WT1 TIMP2 MMP9 MMP2 MMP13 MMP1
2 zinc ion binding GO:0008270 9.87 WT1 TIMP2 MMP9 MMP2 MMP13 MMP1
3 peptidase activity GO:0008233 9.85 MMP9 MMP2 MMP13 MMP1 ADAMTS6
4 integrin binding GO:0005178 9.71 TIMP2 FBN1 FBLN5 COL5A1
5 extracellular matrix structural constituent GO:0005201 9.67 FBN1 ELN EFEMP1 COL5A1
6 endopeptidase activity GO:0004175 9.56 MMP9 MMP2 MMP13 MMP1
7 metallopeptidase activity GO:0008237 9.55 MMP9 MMP2 MMP13 MMP1 ADAMTS6
8 extracellular matrix constituent conferring elasticity GO:0030023 9.13 FBN1 FBLN5 ELN
9 metalloendopeptidase activity GO:0004222 9.02 MMP9 MMP2 MMP13 MMP1 ADAMTS6
Sources

Sources for Inguinal Hernia

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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