MCID: INH003
MIFTS: 25

Inhibited Female Orgasm

Categories: Reproductive diseases

Aliases & Classifications for Inhibited Female Orgasm

MalaCards integrated aliases for Inhibited Female Orgasm:

Name: Inhibited Female Orgasm 12 15
Female Orgasmic Disorder 12 71

Classifications:



External Ids:

Disease Ontology 12 DOID:7518
ICD9CM 34 302.73
NCIt 49 C34958
SNOMED-CT 67 60103007
ICD10 32 F52.31
UMLS 71 C0033948

Summaries for Inhibited Female Orgasm

MalaCards based summary : Inhibited Female Orgasm, also known as female orgasmic disorder, is related to hypoactive sexual desire disorder and sexual disorder. An important gene associated with Inhibited Female Orgasm is IDH3G (Isocitrate Dehydrogenase (NAD(+)) 3 Non-Catalytic Subunit Gamma), and among its related pathways/superpathways are Pyruvate metabolism and Citric Acid (TCA) cycle and Citrate cycle (TCA cycle). The drugs Dopamine and Bupropion have been mentioned in the context of this disorder. Affiliated tissues include breast.

Related Diseases for Inhibited Female Orgasm

Diseases related to Inhibited Female Orgasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 36)
# Related Disease Score Top Affiliating Genes
1 hypoactive sexual desire disorder 29.7 SHBG PRL
2 sexual disorder 29.0 SHBG PRL EHD4
3 d-2-hydroxyglutaric aciduria 1 10.1 IDH3G IDH3A
4 2-hydroxyglutaric aciduria 10.1 IDH3G IDH3A
5 psychosexual disorder 9.8 SHBG PRL
6 estrogen excess 9.8 SHBG PRL
7 steroid inherited metabolic disorder 9.8 SHBG PRL
8 androgenic alopecia 9.8 SHBG PRL
9 alopecia 9.8 SHBG PRL
10 pelvic varices 9.8 SHBG PRL
11 sebaceous gland disease 9.7 SHBG PRL
12 uterine benign neoplasm 9.7 SHBG PRL
13 reproductive organ benign neoplasm 9.7 SHBG PRL
14 acanthosis nigricans 9.7 SHBG PRL
15 anovulation 9.7 SHBG PRL
16 gynecomastia 9.7 SHBG PRL
17 varicocele 9.7 SHBG PRL
18 disorders of sexual development 9.7 SHBG PRL
19 impotence 9.7 SHBG PRL
20 lipoid congenital adrenal hyperplasia 9.7 SHBG PRL
21 hyperprolactinemia 9.7 SHBG PRL
22 insulin-like growth factor i 9.7 SHBG PRL
23 amenorrhea 9.7 SHBG PRL
24 hyperandrogenism 9.7 SHBG PRL
25 thyroid gland disease 9.7 SHBG PRL
26 goiter 9.7 SHBG PRL
27 turner syndrome 9.6 SHBG PRL
28 hypopituitarism 9.6 SHBG PRL
29 congenital hypothyroidism 9.6 SHBG PRL
30 hyperthyroidism 9.6 SHBG PRL
31 acromegaly 9.6 SHBG PRL
32 anorexia nervosa 9.6 SHBG PRL
33 premature ovarian failure 1 9.5 SHBG PRL
34 cryptorchidism, unilateral or bilateral 9.5 SHBG PRL
35 focal epilepsy 9.4 SHBG PRL
36 polycystic ovary syndrome 9.2 SHBG PRL

Graphical network of the top 20 diseases related to Inhibited Female Orgasm:



Diseases related to Inhibited Female Orgasm

Symptoms & Phenotypes for Inhibited Female Orgasm

Drugs & Therapeutics for Inhibited Female Orgasm

Drugs for Inhibited Female Orgasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 2, Phase 3 51-61-6, 62-31-7 681
2
Bupropion Approved Phase 2, Phase 3 34911-55-2, 34841-39-9 444
3 Antidepressive Agents Phase 2, Phase 3
4 Dopamine Agents Phase 2, Phase 3
5 Cytochrome P-450 Enzyme Inhibitors Phase 2, Phase 3
6 Psychotropic Drugs Phase 2, Phase 3
7 Neurotransmitter Agents Phase 2, Phase 3
8
Paroxetine Approved, Investigational Phase 2 61869-08-7 43815
9
Fluoxetine Approved, Vet_approved Phase 2 54910-89-3 3386
10
Sertraline Approved Phase 2 79617-96-2 68617
11
Testosterone Approved, Experimental, Investigational Phase 2 58-22-0, 481-30-1 10204 6013
12 Ginkgo Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Multi-center, Double-blind, Placebo-controlled Study of Bupropion XL in Females With Orgasmic Disorder Completed NCT00248209 Phase 2, Phase 3 Wellbutrin XL
2 A Double Blind Placebo Controlled Trial of Autologous Platelet Rich Plasma (PRP) Peri-urethral and Clitoral Injections for the Treatment of Female Orgasmic Disorder Unknown status NCT03189238 Phase 2
3 Ginkgo Biloba: Antidepressant-Induced Sexual Dysfunction Completed NCT00034021 Phase 2 Ginkgo Biloba
4 A Placebo-Controlled, Randomized, Double-Blind, Parallel-Group, Dose-Finding Trial to Evaluate the Efficacy and Safety of TBS-2 Intranasal Testosterone Gel in Women With Acquired Female Orgasmic Disorder Completed NCT01607658 Phase 2 Placebo;Low dose TBS-2;Medium dose TBS-2;High dose TBS-2

Search NIH Clinical Center for Inhibited Female Orgasm

Genetic Tests for Inhibited Female Orgasm

Anatomical Context for Inhibited Female Orgasm

MalaCards organs/tissues related to Inhibited Female Orgasm:

40
Breast

Publications for Inhibited Female Orgasm

Articles related to Inhibited Female Orgasm:

(show top 50) (show all 52)
# Title Authors PMID Year
1
Female Sexual Dysfunction: Pharmacologic and Therapeutic Interventions. 61
32541291 2020
2
The clitoral activation paradox - Claimed outcomes from different methods of its stimulation. 61
29693269 2018
3
Toward a More Evidence-Based Nosology and Nomenclature for Female Sexual Dysfunctions-Part II. 61
27843072 2016
4
Prevalence of Female Sexual Dysfunction Among Premenopausal Women: A Systematic Review and Meta-Analysis of Observational Studies. 61
27871953 2016
5
A biopsychosocial approach to women's sexual function and dysfunction at midlife: A narrative review. 61
27013288 2016
6
The existing therapeutic interventions for orgasmic disorders: recommendations for culturally competent services, narrative review. 61
26494987 2015
7
Comparison of Elaeagnus angustifolia Extract and Sildenafil Citrate on Female Orgasmic Disorders: A Randomized Clinical Trial. 61
25473627 2014
8
"Standard operating procedures for female orgasmic disorder" is not based on best evidence. 61
23578352 2013
9
Psychological and interpersonal dimensions of sexual function and dysfunction in women: An update. 61
26558096 2013
10
Characterization of orgasmic difficulties by women: focus group evaluation. 61
23802867 2013
11
Correlation of question 15 of the FSDS-DAO with clinician evaluation of female orgasmic disorder. 61
23782579 2013
12
Efficacy of psychological interventions for sexual dysfunction: a systematic review and meta-analysis. 61
23559141 2013
13
Sexual dysfunction in young women with breast cancer. 61
22714701 2013
14
Standard operating procedures for female orgasmic disorder: consensus of the International Society for Sexual Medicine. 61
22970851 2013
15
Psychometric Validation of the Sexual Function Questionnaire in Poland. 61
22363092 2012
16
The effect of major depression on sexual function in women. 61
21883948 2012
17
Female orgasm rates are largely independent of other traits: implications for "female orgasmic disorder" and evolutionary theories of orgasm. 61
21569216 2011
18
Breast cancer treatment and sexual dysfunction: Moroccan women's perception. 61
21668971 2011
19
Application of the sexual health model in the long-term treatment of hypoactive sexual desire and female orgasmic disorder. 61
20878225 2011
20
Female sexual disorders: assessment, diagnosis, and treatment. 61
24725342 2011
21
Female orgasmic disorder. 61
22005203 2011
22
Disorders of orgasm in women: a literature review of etiology and current treatments. 61
20584112 2010
23
The DSM diagnostic criteria for female orgasmic disorder. 61
19784768 2010
24
Women's sexual desire and arousal disorders. 61
20092454 2010
25
Emotional intelligence and its association with orgasmic frequency in women. 61
19453897 2009
26
Evaluation and treatment of female sexual disorders. 61
19440781 2009
27
Normal variations in personality are associated with coital orgasmic infrequency in heterosexual women: a population-based study. 61
18331253 2008
28
Pharmacologic treatment strategies for sexual dysfunction in patients with epilepsy and depression. 61
16871136 2006
29
Prevalence and comorbidity of sexual dysfunctions in a Portuguese clinical sample. 61
16418107 2006
30
Reliability and validity of the Sexual Interest and Desire Inventory-Female (SIDI-F), a scale designed to measure severity of female hypoactive sexual desire disorder. 61
16418104 2006
31
Behavioral assessment of couples' communication in female orgasmic disorder. 61
16418102 2006
32
Validation of the McCoy Female Sexuality Questionnaire in an Italian sample. 61
16362248 2005
33
The use of the sexual function questionnaire as a screening tool for women with sexual dysfunction. 61
16422841 2005
34
Disorders of orgasm in women. 61
16422985 2004
35
The meaning of heterosexual intercourse among women with female orgasmic disorder. 61
12597273 2003
36
Validation of the Female Sexual Function Index (FSFI) in women with female orgasmic disorder and in women with hypoactive sexual desire disorder. 61
12519665 2003
37
Sildenafil citrate for female orgasmic disorder. 61
12085688 2002
38
Gender, sexual dysfunctions, and the Journal of Sex & Marital Therapy. 61
11441517 2001
39
Prevalence of sexual dysfunctions: results from a decade of research. 61
11329727 2001
40
Sildenafil in the treatment of female sexual dysfunction induced by selective serotonin reuptake inhibitors. 61
10394548 1999
41
Definition and classification of female sexual disorders. 61
9647970 1998
42
Sexual dysfunction in treated breast cancer patients. 61
9093723 1997
43
[Anorgasmic women]. 61
1823300 1991
44
Treatment acceptability of alternative sex therapies: a comparative analysis. 61
2072403 1991
45
Incidence and prevalence of the sexual dysfunctions: a critical review of the empirical literature. 61
2205172 1990
46
Inhibited female orgasm resulting from psychotropic drugs. A five-year, updated, clinical review. 61
2405155 1990
47
Antidepressants and inhibited female orgasm: a literature review. 61
3066913 1988
48
Psychiatric drugs and inhibited female orgasm. 61
2902230 1988
49
The epidemiology of the DSM-III psychosexual dysfunctions. 61
3493350 1986
50
Inhibited female orgasm as a side effect of alprazolam. 61
2863987 1985

Variations for Inhibited Female Orgasm

Expression for Inhibited Female Orgasm

Search GEO for disease gene expression data for Inhibited Female Orgasm.

Pathways for Inhibited Female Orgasm

GO Terms for Inhibited Female Orgasm

Biological processes related to Inhibited Female Orgasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 tricarboxylic acid cycle GO:0006099 8.96 IDH3G IDH3A
2 isocitrate metabolic process GO:0006102 8.62 IDH3G IDH3A

Molecular functions related to Inhibited Female Orgasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0016616 9.16 IDH3G IDH3A
2 NAD binding GO:0051287 8.96 IDH3G IDH3A
3 isocitrate dehydrogenase (NAD+) activity GO:0004449 8.62 IDH3G IDH3A

Sources for Inhibited Female Orgasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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