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MCID: INH003
MIFTS: 29

Inhibited Female Orgasm

Categories: Reproductive diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Inhibited Female Orgasm

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MalaCards integrated aliases for Inhibited Female Orgasm:

Name: Inhibited Female Orgasm 12 15
Female Orgasmic Disorder 12 70

Classifications:

MalaCards categories:
Anatomical: Reproductive diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:7518
ICD9CM 34 302.73
NCIt 50 C34958
SNOMED-CT 67 60103007
ICD10 32 F52.31
UMLS 70 C0033948
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Summaries for Inhibited Female Orgasm

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MalaCards based summary : Inhibited Female Orgasm, also known as female orgasmic disorder, is related to hypoactive sexual desire disorder and sexual disorder. An important gene associated with Inhibited Female Orgasm is IDH3G (Isocitrate Dehydrogenase (NAD(+)) 3 Non-Catalytic Subunit Gamma), and among its related pathways/superpathways are Ca, cAMP and Lipid Signaling and cAMP signaling pathway. The drug Testosterone has been mentioned in the context of this disorder. Affiliated tissues include thyroid, ovary and placenta.

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Related Diseases for Inhibited Female Orgasm

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Diseases related to Inhibited Female Orgasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 128)
# Related Disease Score Top Affiliating Genes
1 hypoactive sexual desire disorder 29.8 SHBG PDE5A OXT HTR2A HTR1A
2 sexual disorder 28.7 SHBG PRL PDE5A OXT HTR2A HTR1A
3 mixed cerebral palsy 10.3 SHBG PRL
4 inhibited male orgasm 10.3 OXT HTR1A
5 substance-induced psychosis 10.3 HTR2A HTR1A
6 atypical depressive disorder 10.3 HTR2A HTR1A
7 oculogyric crisis 10.3 HTR2A HTR1A
8 lactocele 10.3 PRL OXT
9 somatization disorder 10.3 OXT HTR1A
10 pedophilia 10.3 PRL OXT
11 estrogen excess 10.2 SHBG PRL
12 delusional disorder 10.2 HTR2A HTR1A
13 haemophilus meningitis 10.2 SHBG OXT
14 postmenopausal atrophic vaginitis 10.2 SHBG AMH
15 schizophreniform disorder 10.2 PRL HTR2A
16 chronic salpingo-oophoritis 10.2 PRL AMH
17 prostatic adenoma 10.2 SHBG PRL
18 depression 10.2 PRL HTR2A HTR1A
19 placenta praevia 10.2 OXTR OXT
20 acute stress disorder 10.2 OXT HTR1A
21 prosopagnosia 10.2 OXTR OXT
22 melancholia 10.2 PRL HTR2A HTR1A
23 salpingitis isthmica nodosa 10.2 PRL AMH
24 paranoid schizophrenia 10.2 PRL HTR2A HTR1A
25 hyperprolactinemia 10.2 SHBG PRL HTR2A
26 pulmonary venoocclusive disease 10.2 PDE5A HTR2A
27 subserous uterine fibroid 10.1 OXT AMH
28 schizoaffective disorder 10.1 PRL HTR2A HTR1A
29 ovarian benign neoplasm 10.1 PRL AMH
30 body dysmorphic disorder 10.1 OXT HTR2A
31 lipoid proteinosis of urbach and wiethe 10.1 OXTR OXT
32 premature ejaculation 10.1 PDE5A OXT HTR1A
33 sexual sadism 10.1 PRL PDE5A OXT
34 dysthymic disorder 10.1 HTR2A HTR1A
35 intermittent explosive disorder 10.1 OXT HTR2A HTR1A
36 neurotic disorder 10.1 OXT HTR2A HTR1A
37 hypochondriasis 10.1 OXT HTR2A HTR1A
38 adjustment disorder 10.1 OXT HTR2A HTR1A
39 phobia, specific 10.1 OXT HTR2A HTR1A
40 atypical autism 10.1 OXTR OXT
41 impulse control disorder 10.1 HTR2A HTR1A
42 separation anxiety disorder 10.1 OXTR OXT HTR1A
43 alexithymia 10.1 OXTR OXT HTR1A
44 steroid inherited metabolic disorder 10.1 SHBG PRL AMH
45 sebaceous gland disease 10.1 SHBG PRL AMH
46 anovulation 10.1 SHBG PRL AMH
47 gynecomastia 10.1 SHBG PRL CYP3A4
48 disorder of sexual development 10.1 SHBG PRL AMH
49 adenomyosis 10.1 PRL OXTR OXT
50 bestiality 10.0 OXTR OXT HTR2A

Graphical network of the top 20 diseases related to Inhibited Female Orgasm:



Diseases related to Inhibited Female Orgasm
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Symptoms & Phenotypes for Inhibited Female Orgasm

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Drugs & Therapeutics for Inhibited Female Orgasm

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Drugs for Inhibited Female Orgasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Testosterone Approved, Investigational Phase 2 58-22-0 6013

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Double Blind Placebo Controlled Trial of Autologous Platelet Rich Plasma (PRP) Peri-urethral and Clitoral Injections for the Treatment of Female Orgasmic Disorder Unknown status NCT03189238 Phase 2
2 A Placebo-Controlled, Randomized, Double-Blind, Parallel-Group, Dose-Finding Trial to Evaluate the Efficacy and Safety of TBS-2 Intranasal Testosterone Gel in Women With Acquired Female Orgasmic Disorder Completed NCT01607658 Phase 2 Placebo;Low dose TBS-2;Medium dose TBS-2;High dose TBS-2

Search NIH Clinical Center for Inhibited Female Orgasm

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Genetic Tests for Inhibited Female Orgasm

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Anatomical Context for Inhibited Female Orgasm

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MalaCards organs/tissues related to Inhibited Female Orgasm:

40
Thyroid, Ovary, Placenta, Tongue
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Publications for Inhibited Female Orgasm

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Articles related to Inhibited Female Orgasm:

(show top 50) (show all 53)
# Title Authors PMID Year
1
Psychological and Behavioral Treatment of Female Orgasmic Disorder. 61
33069622 2020
2
Female Sexual Dysfunction: Pharmacologic and Therapeutic Interventions. 61
32541291 2020
3
The clitoral activation paradox - Claimed outcomes from different methods of its stimulation. 61
29693269 2018
4
Toward a More Evidence-Based Nosology and Nomenclature for Female Sexual Dysfunctions-Part II. 61
27843072 2016
5
Prevalence of Female Sexual Dysfunction Among Premenopausal Women: A Systematic Review and Meta-Analysis of Observational Studies. 61
27871953 2016
6
A biopsychosocial approach to women's sexual function and dysfunction at midlife: A narrative review. 61
27013288 2016
7
The existing therapeutic interventions for orgasmic disorders: recommendations for culturally competent services, narrative review. 61
26494987 2015
8
Comparison of Elaeagnus angustifolia Extract and Sildenafil Citrate on Female Orgasmic Disorders: A Randomized Clinical Trial. 61
25473627 2014
9
"Standard operating procedures for female orgasmic disorder" is not based on best evidence. 61
23578352 2013
10
Psychological and interpersonal dimensions of sexual function and dysfunction in women: An update. 61
26558096 2013
11
Correlation of question 15 of the FSDS-DAO with clinician evaluation of female orgasmic disorder. 61
23782579 2013
12
Characterization of orgasmic difficulties by women: focus group evaluation. 61
23802867 2013
13
Efficacy of psychological interventions for sexual dysfunction: a systematic review and meta-analysis. 61
23559141 2013
14
Sexual dysfunction in young women with breast cancer. 61
22714701 2013
15
Standard operating procedures for female orgasmic disorder: consensus of the International Society for Sexual Medicine. 61
22970851 2013
16
Psychometric Validation of the Sexual Function Questionnaire in Poland. 61
22363092 2012
17
The effect of major depression on sexual function in women. 61
21883948 2012
18
Female orgasm rates are largely independent of other traits: implications for "female orgasmic disorder" and evolutionary theories of orgasm. 61
21569216 2011
19
Breast cancer treatment and sexual dysfunction: Moroccan women's perception. 61
21668971 2011
20
Application of the sexual health model in the long-term treatment of hypoactive sexual desire and female orgasmic disorder. 61
20878225 2011
21
Female sexual disorders: assessment, diagnosis, and treatment. 61
24725342 2011
22
Female orgasmic disorder. 61
22005203 2011
23
Disorders of orgasm in women: a literature review of etiology and current treatments. 61
20584112 2010
24
The DSM diagnostic criteria for female orgasmic disorder. 61
19784768 2010
25
Women's sexual desire and arousal disorders. 61
20092454 2010
26
Emotional intelligence and its association with orgasmic frequency in women. 61
19453897 2009
27
Evaluation and treatment of female sexual disorders. 61
19440781 2009
28
Normal variations in personality are associated with coital orgasmic infrequency in heterosexual women: a population-based study. 61
18331253 2008
29
Pharmacologic treatment strategies for sexual dysfunction in patients with epilepsy and depression. 61
16871136 2006
30
Prevalence and comorbidity of sexual dysfunctions in a Portuguese clinical sample. 61
16418107 2006
31
Reliability and validity of the Sexual Interest and Desire Inventory-Female (SIDI-F), a scale designed to measure severity of female hypoactive sexual desire disorder. 61
16418104 2006
32
Behavioral assessment of couples' communication in female orgasmic disorder. 61
16418102 2006
33
Validation of the McCoy Female Sexuality Questionnaire in an Italian sample. 61
16362248 2005
34
The use of the sexual function questionnaire as a screening tool for women with sexual dysfunction. 61
16422841 2005
35
Disorders of orgasm in women. 61
16422985 2004
36
The meaning of heterosexual intercourse among women with female orgasmic disorder. 61
12597273 2003
37
Validation of the Female Sexual Function Index (FSFI) in women with female orgasmic disorder and in women with hypoactive sexual desire disorder. 61
12519665 2003
38
Sildenafil citrate for female orgasmic disorder. 61
12085688 2002
39
Gender, sexual dysfunctions, and the Journal of Sex & Marital Therapy. 61
11441517 2001
40
Prevalence of sexual dysfunctions: results from a decade of research. 61
11329727 2001
41
Sildenafil in the treatment of female sexual dysfunction induced by selective serotonin reuptake inhibitors. 61
10394548 1999
42
Definition and classification of female sexual disorders. 61
9647970 1998
43
Sexual dysfunction in treated breast cancer patients. 61
9093723 1997
44
[Anorgasmic women]. 61
1823300 1991
45
Treatment acceptability of alternative sex therapies: a comparative analysis. 61
2072403 1991
46
Incidence and prevalence of the sexual dysfunctions: a critical review of the empirical literature. 61
2205172 1990
47
Inhibited female orgasm resulting from psychotropic drugs. A five-year, updated, clinical review. 61
2405155 1990
48
Antidepressants and inhibited female orgasm: a literature review. 61
3066913 1988
49
Psychiatric drugs and inhibited female orgasm. 61
2902230 1988
50
The epidemiology of the DSM-III psychosexual dysfunctions. 61
3493350 1986
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Variations for Inhibited Female Orgasm

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Expression for Inhibited Female Orgasm

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Search GEO for disease gene expression data for Inhibited Female Orgasm.
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Pathways for Inhibited Female Orgasm

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Pathways related to Inhibited Female Orgasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Ca, cAMP and Lipid Signaling 4
11.44 PDE5A HTR1A ALB
2
cAMP signaling pathway 36
11.26 OXTR OXT HTR1A AMH
3
Serotonergic synapse 36
11.19 HTR2A HTR1A CYP2C19
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GO Terms for Inhibited Female Orgasm

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Biological processes related to Inhibited Female Orgasm according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cytosolic calcium ion concentration GO:0007204 9.77 OXTR OXT HTR2A
2 response to organic cyclic compound GO:0014070 9.73 OXTR OXT AMH
3 female pregnancy GO:0007565 9.71 PRL OXTR OXT
4 memory GO:0007613 9.69 OXTR OXT HTR2A
5 drug metabolic process GO:0017144 9.6 CYP3A4 CYP2C19
6 eating behavior GO:0042755 9.58 OXTR OXT
7 exogenous drug catabolic process GO:0042738 9.58 CYP3A4 CYP2C19
8 positive regulation of blood pressure GO:0045777 9.57 OXTR OXT
9 behavior GO:0007610 9.55 HTR2A HTR1A
10 maternal behavior GO:0042711 9.52 OXTR OXT
11 positive regulation of uterine smooth muscle contraction GO:0070474 9.49 OXTR OXT
12 heterocycle metabolic process GO:0046483 9.48 CYP3A4 CYP2C19
13 serotonin receptor signaling pathway GO:0007210 9.46 HTR2A HTR1A
14 negative regulation of gastric acid secretion GO:0060455 9.43 OXTR OXT
15 monoterpenoid metabolic process GO:0016098 9.4 CYP3A4 CYP2C19
16 isocitrate metabolic process GO:0006102 9.37 IDH3G IDH3A
17 positive regulation of penile erection GO:0060406 9.32 OXTR OXT
18 sperm ejaculation GO:0042713 9.26 OXTR OXT
19 positive regulation of norepinephrine secretion GO:0010701 9.16 OXTR OXT
20 regulation of digestive system process GO:0044058 8.96 OXTR OXT
21 sleep GO:0030431 8.8 OXTR OXT HTR2A

Molecular functions related to Inhibited Female Orgasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.43 PRL OXT AMH
2 aromatase activity GO:0070330 9.32 CYP3A4 CYP2C19
3 serotonin binding GO:0051378 9.16 HTR2A HTR1A
4 isocitrate dehydrogenase (NAD+) activity GO:0004449 8.96 IDH3G IDH3A
5 oxygen binding GO:0019825 8.8 CYP3A4 CYP2C19 ALB
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Sources for Inhibited Female Orgasm

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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