MCID: INH003
MIFTS: 24

Inhibited Female Orgasm

Categories: Reproductive diseases

Aliases & Classifications for Inhibited Female Orgasm

MalaCards integrated aliases for Inhibited Female Orgasm:

Name: Inhibited Female Orgasm 12 15
Female Orgasmic Disorder 12 74

Classifications:



External Ids:

Disease Ontology 12 DOID:7518
ICD9CM 36 302.73
NCIt 51 C34958
SNOMED-CT 69 60103007
ICD10 34 F52.31
UMLS 74 C0033948

Summaries for Inhibited Female Orgasm

MalaCards based summary : Inhibited Female Orgasm, also known as female orgasmic disorder, is related to hypoactive sexual desire disorder. An important gene associated with Inhibited Female Orgasm is IDH3A (Isocitrate Dehydrogenase 3 (NAD(+)) Alpha), and among its related pathways/superpathways are Carbon metabolism and Pyruvate metabolism and Citric Acid (TCA) cycle. The drugs Dopamine and Bupropion have been mentioned in the context of this disorder. Related phenotype is Decreased human papilloma virus 16 (HPV16) pseudovirus infection.

Related Diseases for Inhibited Female Orgasm

Diseases related to Inhibited Female Orgasm via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 hypoactive sexual desire disorder 10.0

Symptoms & Phenotypes for Inhibited Female Orgasm

GenomeRNAi Phenotypes related to Inhibited Female Orgasm according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased human papilloma virus 16 (HPV16) pseudovirus infection GR00306-A 8.8 IDH3A PRL PROS1

Drugs & Therapeutics for Inhibited Female Orgasm

Drugs for Inhibited Female Orgasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 26)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 2, Phase 3 62-31-7, 51-61-6 681
2
Bupropion Approved Phase 2, Phase 3 34841-39-9, 34911-55-2 444
3 Cytochrome P-450 Enzyme Inhibitors Phase 2, Phase 3
4 Dopamine Agents Phase 2, Phase 3
5 Antidepressive Agents Phase 2, Phase 3
6 Neurotransmitter Uptake Inhibitors Phase 2, Phase 3
7 Antidepressive Agents, Second-Generation Phase 2, Phase 3
8 Psychotropic Drugs Phase 2, Phase 3
9 Neurotransmitter Agents Phase 2, Phase 3
10 Cytochrome P-450 CYP2D6 Inhibitors Phase 2, Phase 3
11 Dopamine Uptake Inhibitors Phase 2, Phase 3
12
Testosterone Approved, Experimental, Investigational Phase 2 58-22-0, 481-30-1 6013 10204
13
Testosterone enanthate Approved Phase 2 315-37-7 9416
14
Testosterone undecanoate Approved, Investigational Phase 2 5949-44-0
15
Methyltestosterone Approved Phase 2 58-18-4 6010
16
Paroxetine Approved, Investigational Phase 2 61869-08-7 43815
17
Sertraline Approved Phase 2 79617-96-2 68617
18
Fluoxetine Approved, Vet_approved Phase 2 54910-89-3 3386
19 Anabolic Agents Phase 2
20 Antineoplastic Agents, Hormonal Phase 2
21 Hormone Antagonists Phase 2
22 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
23 Testosterone 17 beta-cypionate Phase 2
24 Hormones Phase 2
25 Androgens Phase 2
26 Ginkgo Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Female Orgasmic Disorder (FOD) and Wellbutrin XL Completed NCT00248209 Phase 2, Phase 3 Wellbutrin XL
2 Efficacy and Safety of TBS-2 Testosterone Gel in Women With Acquired Female Orgasmic Disorder Completed NCT01607658 Phase 2 Placebo;Low dose TBS-2;Medium dose TBS-2;High dose TBS-2
3 Ginkgo Biloba: Antidepressant-Induced Sexual Dysfunction Completed NCT00034021 Phase 2 Ginkgo Biloba
4 Platelet Rich Plasma (PRP) Peri-urethral and Clitoral Injections for the Treatment of Female Orgasmic Disorder Recruiting NCT03189238 Phase 2
5 Effects of Early Abuse on Adult Intimate Relationships Completed NCT01803802 Not Applicable

Search NIH Clinical Center for Inhibited Female Orgasm

Genetic Tests for Inhibited Female Orgasm

Anatomical Context for Inhibited Female Orgasm

Publications for Inhibited Female Orgasm

Articles related to Inhibited Female Orgasm:

(show all 17)
# Title Authors Year
1
Standard operating procedures for female orgasmic disorder: consensus of the International Society for Sexual Medicine. ( 22970851 )
2013
2
"Standard operating procedures for female orgasmic disorder" is not based on best evidence. ( 23578352 )
2013
3
Correlation of question 15 of the FSDS-DAO with clinician evaluation of female orgasmic disorder. ( 23782579 )
2013
4
Application of the sexual health model in the long-term treatment of hypoactive sexual desire and female orgasmic disorder. ( 20878225 )
2011
5
Female orgasm rates are largely independent of other traits: implications for "female orgasmic disorder" and evolutionary theories of orgasm. ( 21569216 )
2011
6
Female orgasmic disorder. ( 22005203 )
2011
7
The DSM diagnostic criteria for female orgasmic disorder. ( 19784768 )
2010
8
Behavioral assessment of couples' communication in female orgasmic disorder. ( 16418102 )
2006
9
Validation of the Female Sexual Function Index (FSFI) in women with female orgasmic disorder and in women with hypoactive sexual desire disorder. ( 12519665 )
2003
10
The meaning of heterosexual intercourse among women with female orgasmic disorder. ( 12597273 )
2003
11
Sildenafil citrate for female orgasmic disorder. ( 12085688 )
2002
12
Inhibited female orgasm resulting from psychotropic drugs. A five-year, updated, clinical review. ( 2405155 )
1990
13
Antidepressants and inhibited female orgasm: a literature review. ( 3066913 )
1988
14
Psychiatric drugs and inhibited female orgasm. ( 2902230 )
1988
15
Inhibited female orgasm as a side effect of alprazolam. ( 2863987 )
1985
16
Inhibited female orgasm resulting from psychotropic drugs. A clinical review. ( 6887155 )
1983
17
MAOI-induced inhibited female orgasm. ( 6614264 )
1983

Variations for Inhibited Female Orgasm

Expression for Inhibited Female Orgasm

Search GEO for disease gene expression data for Inhibited Female Orgasm.

Pathways for Inhibited Female Orgasm

GO Terms for Inhibited Female Orgasm

Cellular components related to Inhibited Female Orgasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrial matrix GO:0005759 8.62 IDH3A IDH3G

Biological processes related to Inhibited Female Orgasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 carbohydrate metabolic process GO:0005975 8.96 IDH3A IDH3G
2 tricarboxylic acid cycle GO:0006099 8.62 IDH3A IDH3G

Molecular functions related to Inhibited Female Orgasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 magnesium ion binding GO:0000287 9.26 IDH3A IDH3G
2 NAD binding GO:0051287 9.16 IDH3A IDH3G
3 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0016616 8.96 IDH3A IDH3G
4 isocitrate dehydrogenase (NAD+) activity GO:0004449 8.62 IDH3A IDH3G

Sources for Inhibited Female Orgasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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