MCID: INH002
MIFTS: 28

Inhibited Male Orgasm

Categories: Reproductive diseases

Aliases & Classifications for Inhibited Male Orgasm

MalaCards integrated aliases for Inhibited Male Orgasm:

Name: Inhibited Male Orgasm 12 15
Male Orgasmic Disorder 12 71
Psychosexual Dysfunction with Male Orgasmic Disorder 71

Classifications:



External Ids:

Disease Ontology 12 DOID:5576
NCIt 50 C34959
SNOMED-CT 67 81903006
ICD10 32 F52.32
UMLS 71 C0033949 C1456319

Summaries for Inhibited Male Orgasm

MalaCards based summary : Inhibited Male Orgasm, also known as male orgasmic disorder, is related to impotence and inhibited female orgasm. An important gene associated with Inhibited Male Orgasm is OGN (Osteoglycin), and among its related pathways/superpathways are cAMP signaling pathway and Serotonergic synapse. Related phenotypes are growth/size/body region and homeostasis/metabolism

Wikipedia : 74 Anorgasmia is a type of sexual dysfunction in which a person cannot achieve orgasm despite adequate... more...

Related Diseases for Inhibited Male Orgasm

Diseases related to Inhibited Male Orgasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 90)
# Related Disease Score Top Affiliating Genes
1 impotence 10.2
2 inhibited female orgasm 10.1 OXT HTR1A
3 animal phobia 10.1 SLC6A4 OXT
4 cyclothymic disorder 10.1 SLC6A4 HTR2C
5 body dysmorphic disorder 10.1 SLC6A4 OXT
6 kleptomania 10.0 SLC6A4 HTR1A
7 atypical depressive disorder 10.0 SLC6A4 HTR1A
8 retrograde amnesia 10.0 SLC6A4 HTR1A
9 pain agnosia 10.0 OXT HTR1A
10 bestiality 10.0 SLC6A3 OXT
11 tic disorder 10.0 SLC6A4 SLC6A3
12 agnosia 10.0 OXT HTR1A
13 diamond-blackfan anemia 5 10.0 SLC6A4 HTR1A
14 melancholia 10.0 SLC6A4 HTR1A
15 schizophreniform disorder 10.0 SLC6A3 HTR2C
16 drug psychosis 10.0 SLC6A3 HTR1A
17 drug-induced mental disorder 10.0 SLC6A3 HTR1A
18 agoraphobia 10.0 SLC6A4 HTR1A
19 lingual-facial-buccal dyskinesia 10.0 SLC6A3 HTR2C
20 amnestic disorder 10.0 OXT OGN HTR1A
21 paranoid schizophrenia 10.0 SLC6A4 HTR1A
22 alcoholic psychosis 10.0 SLC6A4 SLC6A3
23 amphetamine abuse 10.0 SLC6A4 SLC6A3
24 hypoactive sexual desire disorder 10.0 OXT HTR2C HTR1A
25 dissociative disorder 9.9 SLC6A4 OXT OGN
26 withdrawal disorder 9.9 SLC6A3 HTR1A
27 migraine without aura 9.9 SLC6A4 HTR1A
28 heroin dependence 9.9 SLC6A4 SLC6A3
29 somatization disorder 9.9 SLC6A4 OXT HTR1A
30 neurotic disorder 9.9 SLC6A4 OXT HTR1A
31 depression 9.9 SLC6A4 HTR2C HTR1A
32 bulimia nervosa 9.9 SLC6A4 OXT HTR2C
33 acute stress disorder 9.9 SLC6A4 OXT HTR1A
34 phobia, specific 9.9 SLC6A4 OXT HTR1A
35 serotonin syndrome 9.9 SLC6A4 OXT HTR1A
36 opiate dependence 9.9 SLC6A4 SLC6A3
37 alexithymia 9.9 SLC6A4 OXT HTR1A
38 reticuloendotheliosis, x-linked 9.9 RELA REL
39 social phobia 9.9 SLC6A4 OXT HTR1A
40 postpartum depression 9.9 SLC6A4 OXT HTR1A
41 bruxism 9.8 SLC6A4 HTR2C HTR1A
42 bipolar i disorder 9.8 SLC6A4 HTR2C HTR1A
43 delusional disorder 9.8 SLC6A3 HTR2C HTR1A
44 oppositional defiant disorder 9.8 SLC6A4 SLC6A3 OXT
45 antisocial personality disorder 9.8 SLC6A4 SLC6A3 OXT
46 eating disorder 9.7 SLC6A4 SLC6A3 HTR2C
47 pathological gambling 9.7 SLC6A4 SLC6A3 HTR1A
48 cocaine abuse 9.7 SLC6A4 SLC6A3
49 migraine with aura 9.7 SLC6A4 SLC6A3 HTR2C
50 generalized anxiety disorder 9.7 SLC6A4 SLC6A3 HTR1A

Graphical network of the top 20 diseases related to Inhibited Male Orgasm:



Diseases related to Inhibited Male Orgasm

Symptoms & Phenotypes for Inhibited Male Orgasm

MGI Mouse Phenotypes related to Inhibited Male Orgasm:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.8 HTR2C OGN OXT REL RELA SLC6A3
2 homeostasis/metabolism MP:0005376 9.76 HTR1A HTR2C OGN OXT REL RELA
3 integument MP:0010771 9.5 HTR2C OGN OXT REL RELA SLC6A3
4 nervous system MP:0003631 9.17 HTR1A HTR2C OXT REL RELA SLC6A3

Drugs & Therapeutics for Inhibited Male Orgasm

Search Clinical Trials , NIH Clinical Center for Inhibited Male Orgasm

Genetic Tests for Inhibited Male Orgasm

Anatomical Context for Inhibited Male Orgasm

Publications for Inhibited Male Orgasm

Articles related to Inhibited Male Orgasm:

(show all 15)
# Title Authors PMID Year
1
Cabergoline in the Treatment of Male Orgasmic Disorder-A Retrospective Pilot Analysis. 61
26944776 2016
2
Sexual dysfunction--a silent hurt: issues on treatment awareness. 61
21091876 2011
3
Sexual dysfunction among secondary school teachers in Ilorin, Nigeria. 61
20345733 2010
4
Comments on "Considerations for a better definition of male orgasmic disorder in DSM V". 61
20492419 2010
5
Considerations for a better definition of male orgasmic disorder in DSM V. 61
20492418 2010
6
Male anorgasmia treated with oxytocin. 61
18086171 2008
7
Retarded ejaculation - a review. 61
16509998 2006
8
Retarded ejaculation in men: an overview of psychological and neurobiological insights. 61
15937707 2005
9
Prevalence of sexual dysfunctions: results from a decade of research. 61
11329727 2001
10
Chronic renal failure and sexual functioning: clinical status versus objectively assessed sexual response. 61
9430867 1997
11
Resolution of erectile dysfunction and inhibited male orgasm in a single homosexual male and transfer of inhibited male orgasm cure to his partner: a case report. 61
9230493 1997
12
Low-dose imipramine for thioridazine-induced male orgasmic disorder. 61
8880656 1996
13
Sexual dysfunction, Part II: Diagnosis, management, and prognosis. 61
1575070 1992
14
Incidence and prevalence of the sexual dysfunctions: a critical review of the empirical literature. 61
2205172 1990
15
The epidemiology of the DSM-III psychosexual dysfunctions. 61
3493350 1986

Variations for Inhibited Male Orgasm

Expression for Inhibited Male Orgasm

Search GEO for disease gene expression data for Inhibited Male Orgasm.

Pathways for Inhibited Male Orgasm

Pathways related to Inhibited Male Orgasm according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1 11.88 RELA OXT HTR1A
2 11.39 SLC6A4 HTR2C HTR1A
3
Show member pathways
11.35 RELA REL
4 11.27 RELA REL
5
Show member pathways
11.26 RELA REL
6
Show member pathways
11.22 RELA REL
7 11.14 RELA REL
8 11.12 RELA REL
9
Show member pathways
11.09 SLC6A4 SLC6A3
10 11.05 RELA REL
11 10.92 RELA REL
12
Show member pathways
10.72 SLC6A4 SLC6A3
13 10.58 SLC6A4 HTR2C HTR1A
14 10.4 RELA REL
15
Show member pathways
10.16 SLC6A4 SLC6A3 HTR1A

GO Terms for Inhibited Male Orgasm

Cellular components related to Inhibited Male Orgasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of presynaptic membrane GO:0099056 9.16 SLC6A4 SLC6A3
2 integral component of postsynaptic membrane GO:0099055 8.96 SLC6A4 SLC6A3
3 synapse GO:0045202 8.92 SLC6A4 RELA HTR2C HTR1A

Biological processes related to Inhibited Male Orgasm according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 9.58 HTR2C HTR1A
2 response to organic cyclic compound GO:0014070 9.58 SLC6A3 RELA OXT
3 response to cytokine GO:0034097 9.57 RELA REL
4 social behavior GO:0035176 9.56 SLC6A4 OXT
5 neurotransmitter transport GO:0006836 9.55 SLC6A4 SLC6A3
6 response to cocaine GO:0042220 9.54 SLC6A3 OXT
7 response to progesterone GO:0032570 9.52 RELA OXT
8 G protein-coupled serotonin receptor signaling pathway GO:0098664 9.51 HTR2C HTR1A
9 behavioral fear response GO:0001662 9.49 HTR2C HTR1A
10 vasoconstriction GO:0042310 9.48 SLC6A4 HTR1A
11 behavior GO:0007610 9.46 HTR2C HTR1A
12 response to drug GO:0042493 9.46 SLC6A4 SLC6A3 RELA HTR2C
13 neurotransmitter biosynthetic process GO:0042136 9.43 SLC6A4 SLC6A3
14 regulation of dopamine metabolic process GO:0042053 9.37 SLC6A3 HTR1A
15 cellular response to stress GO:0033554 9.32 RELA REL
16 monoamine transport GO:0015844 9.26 SLC6A4 SLC6A3
17 sperm ejaculation GO:0042713 8.96 SLC6A4 OXT
18 response to cAMP GO:0051591 8.8 SLC6A3 RELA OXT

Molecular functions related to Inhibited Male Orgasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G protein-coupled serotonin receptor activity GO:0004993 9.26 HTR2C HTR1A
2 neurotransmitter transporter activity GO:0005326 9.16 SLC6A4 SLC6A3
3 monoamine transmembrane transporter activity GO:0008504 8.96 SLC6A4 SLC6A3
4 serotonin binding GO:0051378 8.8 SLC6A4 HTR2C HTR1A

Sources for Inhibited Male Orgasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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