Inhibited Male Orgasm disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Inhibited Male Orgasm

MalaCards integrated aliases for Inhibited Male Orgasm:

Name: Inhibited Male Orgasm ¹¹ ¹⁴ ⁷⁵

Male Orgasmic Disorder ¹¹ ⁷¹

Psychosexual Dysfunction with Male Orgasmic Disorder ⁷¹

Classifications:

MalaCards categories:
Anatomical: Reproductive diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹¹ DOID:5576

NCIt ⁴⁹ C34959

SNOMED-CT ⁶⁸ 81903006

UMLS ⁷¹ C0033949 C1456319

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Summaries for Inhibited Male Orgasm

MalaCards based summary: Inhibited Male Orgasm, also known as male orgasmic disorder, is related to impotence and multiple personality disorder. An important gene associated with Inhibited Male Orgasm is OXT (Oxytocin/Neurophysin I Prepropeptide), and among its related pathways/superpathways are Sudden infant death syndrome (SIDS) susceptibility pathways and Monoamine GPCRs. Related phenotypes are homeostasis/metabolism and nervous system

Wikipedia: ⁷⁵ Anorgasmia is a type of sexual dysfunction in which a person cannot achieve orgasm despite adequate... more...

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Related Diseases for Inhibited Male Orgasm

Diseases related to Inhibited Male Orgasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 129)

#	Related Disease	Score	Top Affiliating Genes
1	impotence	29.8	SHBG PRL HTR2C HTR1A ARG2
2	multiple personality disorder	10.3	OXT OGN
3	animal phobia	10.3	SLC6A4 OXT
4	kluver-bucy syndrome	10.2	SLC6A4 OXT
5	cascade stomach	10.2	SLC6A4 HTR1A
6	tetanus neonatorum	10.2	OXT KANTR
7	voyeurism	10.2	OXT MAOA
8	somatization disorder	10.2	SLC6A4 OXT
9	narcissistic personality disorder	10.2	OXT MAOA
10	plantar fascial fibromatosis	10.2	SLC6A4 OGN
11	cyclothymic disorder	10.2	SLC6A4 HTR1A
12	amnestic disorder	10.2	OXT OGN HTR1A
13	acute stress disorder	10.2	SLC6A4 OXT OGN
14	exhibitionism	10.2	SLC6A4 MAOA
15	dissociative disorder	10.2	SLC6A4 OXT OGN
16	retrograde amnesia	10.2	SLC6A4 HTR1A
17	alexithymia	10.2	SLC6A4 OXT
18	flying phobia	10.1	OXT MAOA HTR1A
19	lactocele	10.1	PRL OXT
20	cannabis abuse	10.1	SLC6A4 HTR1A
21	postmenopausal atrophic vaginitis	10.1	SHBG OXT
22	breast abscess	10.1	PRL OXT
23	paraphilia disorder	10.1	SLC6A4 OXT MAOA
24	lingual-facial-buccal dyskinesia	10.1	SLC6A3 HTR2C
25	body dysmorphic disorder	10.1	SLC6A4 OXT MAOA
26	atypical depressive disorder	10.1	SLC6A4 MAOA HTR1A
27	drug psychosis	10.1	SLC6A3 HTR2C HTR1A
28	drug-induced mental disorder	10.1	SLC6A3 HTR2C HTR1A
29	substance-induced psychosis	10.1	SLC6A3 HTR2C HTR1A
30	delusional disorder	10.1	SLC6A3 HTR2C HTR1A
31	abducens palsy	10.1	PRL KANTR
32	agoraphobia	10.1	SLC6A4 MAOA HTR1A
33	chronic fatigue syndrome	10.1	SLC6A4 MAOA HTR1A
34	pyromania	10.1	SLC6A4 MAOA HTR1B
35	pervasive developmental disorder	10.1	SLC6A4 OXT HTR1A
36	adjustment disorder	10.1	SLC6A4 OXT OGN HTR1A
37	withdrawal disorder	10.1	SLC6A4 SLC6A3 HTR1A
38	premature ejaculation	10.1	SLC6A4 OXT HTR2C HTR1A
39	cocaine abuse	10.1	SLC6A4 SLC6A3 HTR1A
40	sleep disorder	10.1	SLC6A4 SLC6A3 HTR1A
41	bowel dysfunction	10.0	SLC6A4 SLC6A3 HTR1A
42	amphetamine abuse	10.0	SLC6A4 SLC6A3 HTR1B
43	schizophreniform disorder	10.0	PRL HTR2C
44	avoidant personality disorder	10.0	SLC6A4 SLC6A3 MAOA
45	bruxism	10.0	SLC6A4 KANTR HTR2C HTR1A
46	separation anxiety disorder	10.0	SLC6A4 OXT MAOA HTR1A
47	serotonin syndrome	10.0	SLC6A4 OXT MAOA HTR1A
48	heroin dependence	10.0	SLC6A4 SLC6A3 MAOA
49	phobia, specific	10.0	SLC6A4 OXT MAOA HTR1A
50	sexual sadism	10.0	PRL OXT MAOA

Graphical network of the top 20 diseases related to Inhibited Male Orgasm:

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Symptoms & Phenotypes for Inhibited Male Orgasm

MGI Mouse Phenotypes related to Inhibited Male Orgasm:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	10.03	ARG1 ARG2 HTR1A HTR2C MAOA OGN
2	nervous system	MP:0003631	10.02	ARG1 HTR1A HTR2C MAOA OXT PRL
3	cardiovascular system	MP:0005385	9.81	HTR1A HTR1B MAOA OGN OXT REL
4	behavior/neurological	MP:0005386	9.7	HTR1A HTR1B HTR2C KANTR MAOA OGN
5	integument	MP:0010771	9.23	HTR2C OGN OXT PRL REL RELA

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Drugs & Therapeutics for Inhibited Male Orgasm

Search Clinical Trials, NIH Clinical Center for Inhibited Male Orgasm

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Genetic Tests for Inhibited Male Orgasm

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Anatomical Context for Inhibited Male Orgasm

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Publications for Inhibited Male Orgasm

Articles related to Inhibited Male Orgasm:

(show all 15)

#	Title	Authors	PMID	Year
1	Cabergoline in the Treatment of Male Orgasmic Disorder-A Retrospective Pilot Analysis. ⁶²	Hollander AB...Lipshultz LI	26944776	2016
2	Sexual dysfunction--a silent hurt: issues on treatment awareness. ⁶²	Adegunloye OA...Ezeoke GG	21091876	2011
3	Sexual dysfunction among secondary school teachers in Ilorin, Nigeria. ⁶²	Adegunloye OA...Adelekan ML	20345733	2010
4	Considerations for a better definition of male orgasmic disorder in DSM V. ⁶²	Segraves RT	20492418	2010
5	Comments on "Considerations for a better definition of male orgasmic disorder in DSM V". ⁶²	Wylie K...Perelman MA	20492419	2010
6	Male anorgasmia treated with oxytocin. ⁶²	IsHak WW...Peters A	18086171	2008
7	Retarded ejaculation - a review. ⁶²	Richardson D...Goldmeier D	16509998	2006
8	Retarded ejaculation in men: an overview of psychological and neurobiological insights. ⁶²	Waldinger MD...Schweitzer DH	15937707	2005
9	Prevalence of sexual dysfunctions: results from a decade of research. ⁶²	Simons JS...Carey MP	11329727	2001
10	Chronic renal failure and sexual functioning: clinical status versus objectively assessed sexual response. ⁶²	Toorians AW...Everaerd W	9430867	1997
11	Resolution of erectile dysfunction and inhibited male orgasm in a single homosexual male and transfer of inhibited male orgasm cure to his partner: a case report. ⁶²	Garippa PA...Sanders N	9230493	1997
12	Low-dose imipramine for thioridazine-induced male orgasmic disorder. ⁶²	Aizenberg D...Weizman A	8880656	1996
13	Sexual dysfunction, Part II: Diagnosis, management, and prognosis. ⁶²	Halvorsen JG...Metz ME	1575070	1992
14	Incidence and prevalence of the sexual dysfunctions: a critical review of the empirical literature. ⁶²	Spector IP...Carey MP	2205172	1990
15	The epidemiology of the DSM-III psychosexual dysfunctions. ⁶²	Nathan SG	3493350	1986

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Genes for Inhibited Male Orgasm

Genes related to Inhibited Male Orgasm (0 elite genes):

(show all 16)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	OXT	Oxytocin/Neurophysin I Prepropeptide	Protein Coding	5.2	DISEASES inferred ¹⁴
2	OGN	Osteoglycin	Protein Coding	5.11	DISEASES inferred ¹⁴
3	HTR1A	5-Hydroxytryptamine Receptor 1A	Protein Coding	4.9	DISEASES inferred ¹⁴
4	HTR2C	5-Hydroxytryptamine Receptor 2C	Protein Coding	4.87	DISEASES inferred ¹⁴
5	KANTR	KANTR Integral Membrane Protein	Protein Coding	4.62	DISEASES inferred ¹⁴
6	ELOC	Elongin C	Protein Coding	4.34	DISEASES inferred ¹⁴
7	SLC6A4	Solute Carrier Family 6 Member 4	Protein Coding	4.27	DISEASES inferred ¹⁴
8	HTR1B	5-Hydroxytryptamine Receptor 1B	Protein Coding	4.05	DISEASES inferred ¹⁴
9	MAOA	Monoamine Oxidase A	Protein Coding	3.62	DISEASES inferred ¹⁴
10	ARG2	Arginase 2	Protein Coding	3.42	DISEASES inferred ¹⁴
11	SLC6A3	Solute Carrier Family 6 Member 3	Protein Coding	3.32	DISEASES inferred ¹⁴
12	REL	REL Proto-Oncogene, NF-KB Subunit	Protein Coding	3.28	DISEASES inferred ¹⁴
13	SHBG	Sex Hormone Binding Globulin	Protein Coding	3.14	DISEASES inferred ¹⁴
14	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	3.14	DISEASES inferred ¹⁴
15	ARG1	Arginase 1	Protein Coding	3.06	DISEASES inferred ¹⁴
16	PRL	Prolactin	Protein Coding	2.89	DISEASES inferred ¹⁴

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Variations for Inhibited Male Orgasm

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Expression for Inhibited Male Orgasm

Search GEO for disease gene expression data for Inhibited Male Orgasm.

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Pathways for Inhibited Male Orgasm

Pathways related to Inhibited Male Orgasm according to GeneCards Suite gene sharing:

(show all 11)

#	Super pathways	Score	Top Affiliating Genes
1	Sudden infant death syndrome (SIDS) susceptibility pathways ⁷⁴	11.87	SLC6A4 MAOA HTR1A
2	Monoamine GPCRs ⁷⁴ Show member pathways Adrenaline signalling through Alpha-2 adrenergic receptor ⁶⁶ Adrenoceptors ⁶⁶ Amine ligand-binding receptors ⁶⁶ Histamine receptors ⁶⁶ Muscarinic acetylcholine receptors ⁶⁶ Serotonin receptors ⁶⁶	11.65	HTR2C HTR1B HTR1A
3	Amino acid metabolism ⁷⁴ Show member pathways Amino acid metabolism pathway excerpt: histidine catabolism extension ⁷⁴	11.53	MAOA ARG2 ARG1
4	Monoamine transport ⁷⁴ Show member pathways Serotonin transporter activity ⁷⁴	11.07	SLC6A4 SLC6A3 MAOA
5	LDL- influence on CD14 and TLR4 ⁷⁴	10.8	RELA REL
6	Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics ⁶⁰	10.8	SLC6A4 MAOA HTR2C HTR1B HTR1A
7	Antipsychotics Pathway (Metabolic Side Effects), Pharmacodynamics ⁶⁰	10.76	PRL HTR2C
8	Neurotransmitter clearance ⁶⁶ Show member pathways Dopamine clearance from the synaptic cleft ⁶⁶ Enzymatic degradation of dopamine by COMT ⁶⁶ Enzymatic degradation of Dopamine by monoamine oxidase ⁶⁶ Flavan-3-ol metabolic pathway ⁷⁴ Metabolism of serotonin ⁶⁶ Serotonin clearance from the synaptic cleft ⁶⁶	10.73	SLC6A4 SLC6A3 MAOA
9	Atypical NF-kappaB pathway ⁶¹	10.55	RELA REL
10	Methylphenidate Pathway, Pharmacodynamics ⁶⁰ Show member pathways Dopamine receptors ⁶⁶	10.38	SLC6A4 SLC6A3 MAOA HTR1B HTR1A
11	L-arginine degradation I (arginase pathway) ⁶¹	9.92	ARG2 ARG1

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GO Terms for Inhibited Male Orgasm

Cellular components related to Inhibited Male Orgasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	NF-kappaB complex	GO:0071159	9.56	RELA REL
2	G protein-coupled serotonin receptor complex	GO:0098666	9.46	HTR2C HTR1B
3	obsolete integral component of presynaptic membrane	GO:0099056	9.13	SLC6A4 SLC6A3 HTR1B
4	serotonergic synapse	GO:0099154	8.92	SLC6A4 HTR1B

Biological processes related to Inhibited Male Orgasm according to GeneCards Suite gene sharing:

(show all 17)

#	Name	GO ID	Score	Top Affiliating Genes
1	female pregnancy	GO:0007565	9.96	PRL OXT ARG1
2	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	GO:0007187	9.95	HTR2C HTR1B HTR1A
3	urea cycle	GO:0000050	9.84	ARG2 ARG1
4	regulation of dopamine metabolic process	GO:0042053	9.83	SLC6A3 HTR1A
5	regulation of behavior	GO:0050795	9.81	HTR1B HTR1A
6	drinking behavior	GO:0042756	9.8	OXT HTR1B
7	monoamine transport	GO:0015844	9.76	SLC6A3 SLC6A4
8	dopamine catabolic process	GO:0042420	9.73	MAOA SLC6A3
9	response to cocaine	GO:0042220	9.73	SLC6A3 OXT HTR1B
10	adenylate cyclase-inhibiting serotonin receptor signaling pathway	GO:0007198	9.71	HTR1B HTR1A
11	sperm ejaculation	GO:0042713	9.67	SLC6A4 OXT
12	nitrogen compound transport	GO:0071705	9.57	SLC6A4 SLC6A3
13	cellular response to stress	GO:0033554	9.55	RELA REL
14	arginine metabolic process	GO:0006525	9.32	ARG2 ARG1
15	arginine catabolic process to ornithine	GO:0019547	9.26	ARG2 ARG1
16	negative regulation of macromolecule metabolic process	GO:0010605	9.16	RELA REL
17	behavior	GO:0007610	8.8	HTR2C HTR1B HTR1A

Molecular functions related to Inhibited Male Orgasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	neurotransmitter receptor activity	GO:0030594	9.88	HTR2C HTR1B HTR1A
2	G protein-coupled serotonin receptor activity	GO:0004993	9.73	HTR2C HTR1B HTR1A
3	monoamine transmembrane transporter activity	GO:0008504	9.62	SLC6A4 SLC6A3
4	heterocyclic compound binding	GO:1901363	9.54	SLC6A3 HTR1B
5	arginase activity	GO:0004053	9.46	ARG2 ARG1
6	serotonin binding	GO:0051378	9.23	SLC6A4 HTR2C HTR1B HTR1A
7	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines	GO:0016813	8.96	ARG2 ARG1

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Sources for Inhibited Male Orgasm

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⁵³ Novoseek

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⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

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⁷³ UniProtKB/Swiss-Prot

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⁷⁵ Wikipedia

MCID: INH002 MIFTS: 28	Inhibited Male Orgasm Categories: Reproductive diseases	Data Licensing For inquiries, contact: [email protected]
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