MCID: INH002
MIFTS: 28

Inhibited Male Orgasm

Categories: Reproductive diseases
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Aliases & Classifications for Inhibited Male Orgasm

MalaCards integrated aliases for Inhibited Male Orgasm:

Name: Inhibited Male Orgasm 11 14 75
Male Orgasmic Disorder 11 71
Psychosexual Dysfunction with Male Orgasmic Disorder 71

Classifications:



External Ids:

Disease Ontology 11 DOID:5576
NCIt 49 C34959
SNOMED-CT 68 81903006
UMLS 71 C0033949 C1456319

Summaries for Inhibited Male Orgasm

MalaCards based summary: Inhibited Male Orgasm, also known as male orgasmic disorder, is related to impotence and multiple personality disorder. An important gene associated with Inhibited Male Orgasm is OXT (Oxytocin/Neurophysin I Prepropeptide), and among its related pathways/superpathways are Sudden infant death syndrome (SIDS) susceptibility pathways and Monoamine GPCRs. Related phenotypes are homeostasis/metabolism and nervous system

Wikipedia: 75 Anorgasmia is a type of sexual dysfunction in which a person cannot achieve orgasm despite adequate... more...

Related Diseases for Inhibited Male Orgasm

Diseases related to Inhibited Male Orgasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 129)
# Related Disease Score Top Affiliating Genes
1 impotence 29.8 SHBG PRL HTR2C HTR1A ARG2
2 multiple personality disorder 10.3 OXT OGN
3 animal phobia 10.3 SLC6A4 OXT
4 kluver-bucy syndrome 10.2 SLC6A4 OXT
5 cascade stomach 10.2 SLC6A4 HTR1A
6 tetanus neonatorum 10.2 OXT KANTR
7 voyeurism 10.2 OXT MAOA
8 somatization disorder 10.2 SLC6A4 OXT
9 narcissistic personality disorder 10.2 OXT MAOA
10 plantar fascial fibromatosis 10.2 SLC6A4 OGN
11 cyclothymic disorder 10.2 SLC6A4 HTR1A
12 amnestic disorder 10.2 OXT OGN HTR1A
13 acute stress disorder 10.2 SLC6A4 OXT OGN
14 exhibitionism 10.2 SLC6A4 MAOA
15 dissociative disorder 10.2 SLC6A4 OXT OGN
16 retrograde amnesia 10.2 SLC6A4 HTR1A
17 alexithymia 10.2 SLC6A4 OXT
18 flying phobia 10.1 OXT MAOA HTR1A
19 lactocele 10.1 PRL OXT
20 cannabis abuse 10.1 SLC6A4 HTR1A
21 postmenopausal atrophic vaginitis 10.1 SHBG OXT
22 breast abscess 10.1 PRL OXT
23 paraphilia disorder 10.1 SLC6A4 OXT MAOA
24 lingual-facial-buccal dyskinesia 10.1 SLC6A3 HTR2C
25 body dysmorphic disorder 10.1 SLC6A4 OXT MAOA
26 atypical depressive disorder 10.1 SLC6A4 MAOA HTR1A
27 drug psychosis 10.1 SLC6A3 HTR2C HTR1A
28 drug-induced mental disorder 10.1 SLC6A3 HTR2C HTR1A
29 substance-induced psychosis 10.1 SLC6A3 HTR2C HTR1A
30 delusional disorder 10.1 SLC6A3 HTR2C HTR1A
31 abducens palsy 10.1 PRL KANTR
32 agoraphobia 10.1 SLC6A4 MAOA HTR1A
33 chronic fatigue syndrome 10.1 SLC6A4 MAOA HTR1A
34 pyromania 10.1 SLC6A4 MAOA HTR1B
35 pervasive developmental disorder 10.1 SLC6A4 OXT HTR1A
36 adjustment disorder 10.1 SLC6A4 OXT OGN HTR1A
37 withdrawal disorder 10.1 SLC6A4 SLC6A3 HTR1A
38 premature ejaculation 10.1 SLC6A4 OXT HTR2C HTR1A
39 cocaine abuse 10.1 SLC6A4 SLC6A3 HTR1A
40 sleep disorder 10.1 SLC6A4 SLC6A3 HTR1A
41 bowel dysfunction 10.0 SLC6A4 SLC6A3 HTR1A
42 amphetamine abuse 10.0 SLC6A4 SLC6A3 HTR1B
43 schizophreniform disorder 10.0 PRL HTR2C
44 avoidant personality disorder 10.0 SLC6A4 SLC6A3 MAOA
45 bruxism 10.0 SLC6A4 KANTR HTR2C HTR1A
46 separation anxiety disorder 10.0 SLC6A4 OXT MAOA HTR1A
47 serotonin syndrome 10.0 SLC6A4 OXT MAOA HTR1A
48 heroin dependence 10.0 SLC6A4 SLC6A3 MAOA
49 phobia, specific 10.0 SLC6A4 OXT MAOA HTR1A
50 sexual sadism 10.0 PRL OXT MAOA

Graphical network of the top 20 diseases related to Inhibited Male Orgasm:



Diseases related to Inhibited Male Orgasm

Symptoms & Phenotypes for Inhibited Male Orgasm

MGI Mouse Phenotypes related to Inhibited Male Orgasm:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.03 ARG1 ARG2 HTR1A HTR2C MAOA OGN
2 nervous system MP:0003631 10.02 ARG1 HTR1A HTR2C MAOA OXT PRL
3 cardiovascular system MP:0005385 9.81 HTR1A HTR1B MAOA OGN OXT REL
4 behavior/neurological MP:0005386 9.7 HTR1A HTR1B HTR2C KANTR MAOA OGN
5 integument MP:0010771 9.23 HTR2C OGN OXT PRL REL RELA

Drugs & Therapeutics for Inhibited Male Orgasm

Search Clinical Trials, NIH Clinical Center for Inhibited Male Orgasm

Genetic Tests for Inhibited Male Orgasm

Anatomical Context for Inhibited Male Orgasm

Publications for Inhibited Male Orgasm

Articles related to Inhibited Male Orgasm:

(show all 15)
# Title Authors PMID Year
1
Cabergoline in the Treatment of Male Orgasmic Disorder-A Retrospective Pilot Analysis. 62
26944776 2016
2
Sexual dysfunction--a silent hurt: issues on treatment awareness. 62
21091876 2011
3
Sexual dysfunction among secondary school teachers in Ilorin, Nigeria. 62
20345733 2010
4
Considerations for a better definition of male orgasmic disorder in DSM V. 62
20492418 2010
5
Comments on "Considerations for a better definition of male orgasmic disorder in DSM V". 62
20492419 2010
6
Male anorgasmia treated with oxytocin. 62
18086171 2008
7
Retarded ejaculation - a review. 62
16509998 2006
8
Retarded ejaculation in men: an overview of psychological and neurobiological insights. 62
15937707 2005
9
Prevalence of sexual dysfunctions: results from a decade of research. 62
11329727 2001
10
Chronic renal failure and sexual functioning: clinical status versus objectively assessed sexual response. 62
9430867 1997
11
Resolution of erectile dysfunction and inhibited male orgasm in a single homosexual male and transfer of inhibited male orgasm cure to his partner: a case report. 62
9230493 1997
12
Low-dose imipramine for thioridazine-induced male orgasmic disorder. 62
8880656 1996
13
Sexual dysfunction, Part II: Diagnosis, management, and prognosis. 62
1575070 1992
14
Incidence and prevalence of the sexual dysfunctions: a critical review of the empirical literature. 62
2205172 1990
15
The epidemiology of the DSM-III psychosexual dysfunctions. 62
3493350 1986

Variations for Inhibited Male Orgasm

Expression for Inhibited Male Orgasm

Search GEO for disease gene expression data for Inhibited Male Orgasm.

Pathways for Inhibited Male Orgasm

Pathways related to Inhibited Male Orgasm according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1 11.87 SLC6A4 MAOA HTR1A
2
Show member pathways
11.65 HTR2C HTR1B HTR1A
3
Show member pathways
11.53 MAOA ARG2 ARG1
4
Show member pathways
11.07 SLC6A4 SLC6A3 MAOA
5 10.8 RELA REL
6 10.8 SLC6A4 MAOA HTR2C HTR1B HTR1A
7 10.76 PRL HTR2C
8
Show member pathways
10.73 SLC6A4 SLC6A3 MAOA
9 10.55 RELA REL
10
Show member pathways
10.38 SLC6A4 SLC6A3 MAOA HTR1B HTR1A
11 9.92 ARG2 ARG1

GO Terms for Inhibited Male Orgasm

Cellular components related to Inhibited Male Orgasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 NF-kappaB complex GO:0071159 9.56 RELA REL
2 G protein-coupled serotonin receptor complex GO:0098666 9.46 HTR2C HTR1B
3 obsolete integral component of presynaptic membrane GO:0099056 9.13 SLC6A4 SLC6A3 HTR1B
4 serotonergic synapse GO:0099154 8.92 SLC6A4 HTR1B

Biological processes related to Inhibited Male Orgasm according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 female pregnancy GO:0007565 9.96 PRL OXT ARG1
2 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 9.95 HTR2C HTR1B HTR1A
3 urea cycle GO:0000050 9.84 ARG2 ARG1
4 regulation of dopamine metabolic process GO:0042053 9.83 SLC6A3 HTR1A
5 regulation of behavior GO:0050795 9.81 HTR1B HTR1A
6 drinking behavior GO:0042756 9.8 OXT HTR1B
7 monoamine transport GO:0015844 9.76 SLC6A3 SLC6A4
8 dopamine catabolic process GO:0042420 9.73 MAOA SLC6A3
9 response to cocaine GO:0042220 9.73 SLC6A3 OXT HTR1B
10 adenylate cyclase-inhibiting serotonin receptor signaling pathway GO:0007198 9.71 HTR1B HTR1A
11 sperm ejaculation GO:0042713 9.67 SLC6A4 OXT
12 nitrogen compound transport GO:0071705 9.57 SLC6A4 SLC6A3
13 cellular response to stress GO:0033554 9.55 RELA REL
14 arginine metabolic process GO:0006525 9.32 ARG2 ARG1
15 arginine catabolic process to ornithine GO:0019547 9.26 ARG2 ARG1
16 negative regulation of macromolecule metabolic process GO:0010605 9.16 RELA REL
17 behavior GO:0007610 8.8 HTR2C HTR1B HTR1A

Molecular functions related to Inhibited Male Orgasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neurotransmitter receptor activity GO:0030594 9.88 HTR2C HTR1B HTR1A
2 G protein-coupled serotonin receptor activity GO:0004993 9.73 HTR2C HTR1B HTR1A
3 monoamine transmembrane transporter activity GO:0008504 9.62 SLC6A4 SLC6A3
4 heterocyclic compound binding GO:1901363 9.54 SLC6A3 HTR1B
5 arginase activity GO:0004053 9.46 ARG2 ARG1
6 serotonin binding GO:0051378 9.23 SLC6A4 HTR2C HTR1B HTR1A
7 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines GO:0016813 8.96 ARG2 ARG1

Sources for Inhibited Male Orgasm

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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