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MCID: INH002
MIFTS: 28

Inhibited Male Orgasm

Categories: Reproductive diseases
Genes Related diseases Publications Pathways
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Aliases & Classifications for Inhibited Male Orgasm

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MalaCards integrated aliases for Inhibited Male Orgasm:

Name: Inhibited Male Orgasm 12 15
Male Orgasmic Disorder 12 71
Psychosexual Dysfunction with Male Orgasmic Disorder 71

Classifications:

MalaCards categories:
Anatomical: Reproductive diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:5576
NCIt 49 C34959
SNOMED-CT 67 153261000119109
ICD10 32 F52.32
UMLS 71 C0033949 C1456319
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Summaries for Inhibited Male Orgasm

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MalaCards based summary : Inhibited Male Orgasm, also known as male orgasmic disorder, is related to impotence and somatization disorder. An important gene associated with Inhibited Male Orgasm is OGN (Osteoglycin), and among its related pathways/superpathways are IL-17 Family Signaling Pathways and cAMP signaling pathway. Related phenotypes are behavior/neurological and homeostasis/metabolism

Wikipedia : 74 Anorgasmia is a type of sexual dysfunction in which a person cannot achieve orgasm despite adequate... more...

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Related Diseases for Inhibited Male Orgasm

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Diseases related to Inhibited Male Orgasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 72)
# Related Disease Score Top Affiliating Genes
1 impotence 10.2
2 somatization disorder 10.1 SLC6A4 OXT
3 acute stress disorder 10.1 SLC6A4 OXT
4 kleptomania 10.1 SLC6A4 HTR1A
5 supine hypotensive syndrome 10.1 OXT MAPK14
6 body dysmorphic disorder 10.1 SLC6A4 OXT
7 atypical depressive disorder 10.1 SLC6A4 HTR1A
8 dissociative disorder 10.0 SLC6A4 OXT OGN
9 retrograde amnesia 10.0 SLC6A4 HTR1A
10 hypoactive sexual desire disorder 10.0 OXT HTR2C HTR1A
11 substance-induced psychosis 10.0 SLC6A3 HTR1A
12 trigeminal neuralgia 10.0 SLC6A4 KANTR
13 alcoholic psychosis 10.0 SLC6A4 SLC6A3
14 neurotic disorder 10.0 SLC6A4 HTR1A
15 amphetamine abuse 10.0 SLC6A4 SLC6A3
16 adjustment disorder 10.0 SLC6A4 OGN HTR1A
17 melancholia 9.9 SLC6A4 HTR1A
18 avoidant personality disorder 9.9 SLC6A4 SLC6A3
19 serotonin syndrome 9.9 SLC6A4 OXT HTR1A
20 phobia, specific 9.9 SLC6A4 OXT HTR1A
21 phobic disorder 9.9 SLC6A4 OXT HTR1A
22 alexithymia 9.9 SLC6A4 OXT HTR1A
23 depression 9.9 SLC6A4 HTR2C HTR1A
24 bulimia nervosa 9.9 SLC6A4 OXT HTR2C
25 postpartum depression 9.9 SLC6A4 OXT HTR1A
26 social phobia 9.9 SLC6A4 OXT HTR1A
27 intermittent explosive disorder 9.9 SLC6A4 HTR2C HTR1A
28 endogenous depression 9.9 SLC6A4 OXT HTR1A
29 hypochondriasis 9.9 SLC6A4 HTR2C HTR1A
30 separation anxiety disorder 9.9 SLC6A4 SLC6A3 OXT
31 lingual-facial-buccal dyskinesia 9.9 SLC6A3 HTR2C
32 bipolar i disorder 9.8 SLC6A4 HTR2C HTR1A
33 delusional disorder 9.8 SLC6A3 HTR2C HTR1A
34 dysthymic disorder 9.8 SLC6A4 HTR1A
35 tic disorder 9.8 SLC6A4 SLC6A3 HTR1A
36 impulse control disorder 9.8 SLC6A4 SLC6A3 HTR1A
37 pathological gambling 9.8 SLC6A4 SLC6A3 HTR1A
38 cocaine dependence 9.7 SLC6A4 SLC6A3 HTR2C
39 eating disorder 9.7 SLC6A4 SLC6A3 HTR2C
40 migraine with aura 9.7 SLC6A4 SLC6A3 HTR2C
41 reticuloendotheliosis, x-linked 9.7 RELA REL
42 metachromatic leukodystrophy 9.7 SLC6A4 SLC6A3 HTR1A
43 bruxism 9.7 SLC6A4 KANTR HTR2C HTR1A
44 gilles de la tourette syndrome 9.7 SLC6A4 SLC6A3 HTR1A
45 psychosexual disorder 9.7 SLC6A4 OXT HTR2C HTR1A
46 sexual disorder 9.7 SLC6A4 OXT HTR2C HTR1A
47 speech and communication disorders 9.7 SLC6A3 OXT MAPK14
48 anorexia nervosa 9.6 SLC6A4 OXT HTR2C HTR1A
49 substance abuse 9.6 SLC6A4 SLC6A3 OGN HTR1A
50 specific developmental disorder 9.5 SLC6A4 SLC6A3 OXT HTR1A

Graphical network of the top 20 diseases related to Inhibited Male Orgasm:



Diseases related to Inhibited Male Orgasm
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Symptoms & Phenotypes for Inhibited Male Orgasm

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MGI Mouse Phenotypes related to Inhibited Male Orgasm:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.86 HTR1A HTR2C MAPK14 OXT PRUNE1 REL
2 homeostasis/metabolism MP:0005376 9.81 HTR1A HTR2C MAPK14 OGN OXT REL
3 integument MP:0010771 9.56 HTR2C MAPK14 OGN OXT REL RELA
4 nervous system MP:0003631 9.23 HTR1A HTR2C MAPK14 OXT REL RELA
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Drugs & Therapeutics for Inhibited Male Orgasm

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Search Clinical Trials , NIH Clinical Center for Inhibited Male Orgasm

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Genetic Tests for Inhibited Male Orgasm

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Anatomical Context for Inhibited Male Orgasm

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Publications for Inhibited Male Orgasm

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Articles related to Inhibited Male Orgasm:

(show all 15)
# Title Authors PMID Year
1
Cabergoline in the Treatment of Male Orgasmic Disorder-A Retrospective Pilot Analysis. 61
26944776 2016
2
Sexual dysfunction--a silent hurt: issues on treatment awareness. 61
21091876 2011
3
Sexual dysfunction among secondary school teachers in Ilorin, Nigeria. 61
20345733 2010
4
Considerations for a better definition of male orgasmic disorder in DSM V. 61
20492418 2010
5
Comments on "Considerations for a better definition of male orgasmic disorder in DSM V". 61
20492419 2010
6
Male anorgasmia treated with oxytocin. 61
18086171 2008
7
Retarded ejaculation - a review. 61
16509998 2006
8
Retarded ejaculation in men: an overview of psychological and neurobiological insights. 61
15937707 2005
9
Prevalence of sexual dysfunctions: results from a decade of research. 61
11329727 2001
10
Chronic renal failure and sexual functioning: clinical status versus objectively assessed sexual response. 61
9430867 1997
11
Resolution of erectile dysfunction and inhibited male orgasm in a single homosexual male and transfer of inhibited male orgasm cure to his partner: a case report. 61
9230493 1997
12
Low-dose imipramine for thioridazine-induced male orgasmic disorder. 61
8880656 1996
13
Sexual dysfunction, Part II: Diagnosis, management, and prognosis. 61
1575070 1992
14
Incidence and prevalence of the sexual dysfunctions: a critical review of the empirical literature. 61
2205172 1990
15
The epidemiology of the DSM-III psychosexual dysfunctions. 61
3493350 1986
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Variations for Inhibited Male Orgasm

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Expression for Inhibited Male Orgasm

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Search GEO for disease gene expression data for Inhibited Male Orgasm.
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Pathways for Inhibited Male Orgasm

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Pathways related to Inhibited Male Orgasm according to GeneCards Suite gene sharing:

(show all 20)
# Super pathways Score Top Affiliating Genes
1
IL-17 Family Signaling Pathways 64
Show member pathways
 12.1 RELA REL MAPK14
2
cAMP signaling pathway 36
12.09 RELA OXT HTR1A
3
Development A3 receptor signaling 22
Show member pathways
 12.08 RELA REL MAPK14
4
IL-1 signaling pathway 1
Show member pathways
 12.04 RELA REL MAPK14
5
C-type lectin receptor signaling pathway 36
Show member pathways
 11.94 RELA REL MAPK14
6
Development A2A receptor signaling 22
Show member pathways
 11.75 RELA REL MAPK14
7
Serotonergic synapse 36
11.69 SLC6A4 HTR2C HTR1A
8
IL12-mediated signaling events 1
Show member pathways
 11.66 RELA REL MAPK14
9
TGF-beta Signaling Pathways 64
11.56 RELA REL MAPK14
10
Development_TGF-beta receptor signaling 22
11.4 RELA REL MAPK14
11
Tacrolimus/Cyclosporine Pathway, Pharmacodynamics 60
11.14 RELA REL MAPK14
12
Immune response_IL-6 signaling pathway 22
11.09 RELA REL
13
Monoamine Transport 1
Show member pathways
 11.07 SLC6A4 SLC6A3 MAPK14
14
CD40/CD40L signaling 1
11.02 RELA MAPK14
15
Apoptosis and survival_Anti-apoptotic action of nuclear ESR1 and ESR2 22
10.98 RELA MAPK14
16
Neurotransmitter Clearance In The Synaptic Cleft 65
Show member pathways
 10.91 SLC6A4 SLC6A3
17
NTHi-Induced Signaling 63
10.82 RELA MAPK14
18
Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics 60
10.78 SLC6A4 HTR2C HTR1A
19
Methylphenidate Pathway, Pharmacodynamics 60
Show member pathways
 10.49 SLC6A4 SLC6A3 HTR1A
20
Atypical NF-kappaB pathway 1
9.95 RELA REL MAPK14
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GO Terms for Inhibited Male Orgasm

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Cellular components related to Inhibited Male Orgasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 I-kappaB/NF-kappaB complex GO:0033256 8.62 RELA REL

Biological processes related to Inhibited Male Orgasm according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 response to organic cyclic compound GO:0014070 9.69 SLC6A3 RELA OXT
2 response to drug GO:0042493 9.62 SLC6A4 SLC6A3 RELA HTR2C
3 transport GO:0006810 9.57 SLC6A4 SLC6A3
4 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.56 RELA MAPK14
5 behavioral fear response GO:0001662 9.55 HTR2C HTR1A
6 vasoconstriction GO:0042310 9.54 SLC6A4 HTR1A
7 response to muscle stretch GO:0035994 9.52 RELA MAPK14
8 behavior GO:0007610 9.49 HTR2C HTR1A
9 neurotransmitter biosynthetic process GO:0042136 9.48 SLC6A4 SLC6A3
10 cellular response to stress GO:0033554 9.46 RELA REL
11 response to muramyl dipeptide GO:0032495 9.43 RELA MAPK14
12 cellular response to lipoteichoic acid GO:0071223 9.4 RELA MAPK14
13 regulation of dopamine metabolic process GO:0042053 9.37 SLC6A3 HTR1A
14 monoamine transport GO:0015844 9.26 SLC6A4 SLC6A3
15 serotonin receptor signaling pathway GO:0007210 9.16 HTR2C HTR1A
16 sperm ejaculation GO:0042713 8.96 SLC6A4 OXT
17 response to cAMP GO:0051591 8.8 SLC6A3 RELA OXT

Molecular functions related to Inhibited Male Orgasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G protein-coupled serotonin receptor activity GO:0004993 9.26 HTR2C HTR1A
2 neurotransmitter:sodium symporter activity GO:0005328 9.16 SLC6A4 SLC6A3
3 monoamine transmembrane transporter activity GO:0008504 8.96 SLC6A4 SLC6A3
4 serotonin binding GO:0051378 8.8 SLC6A4 HTR2C HTR1A
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Sources for Inhibited Male Orgasm

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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