Inhibited Male Orgasm disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Sources

Aliases & Classifications for Inhibited Male Orgasm

MalaCards integrated aliases for Inhibited Male Orgasm:

Name: Inhibited Male Orgasm ¹² ¹⁵

Male Orgasmic Disorder ¹² ⁷¹

Psychosexual Dysfunction with Male Orgasmic Disorder ⁷¹

Classifications:

MalaCards categories:
Anatomical: Reproductive diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:5576

NCIt ⁵⁰ C34959

SNOMED-CT ⁶⁷ 81903006

ICD10 ³² F52.32

UMLS ⁷¹ C0033949 C1456319

Sources

Summaries for Inhibited Male Orgasm

MalaCards based summary : Inhibited Male Orgasm, also known as male orgasmic disorder, is related to impotence and inhibited female orgasm. An important gene associated with Inhibited Male Orgasm is OGN (Osteoglycin), and among its related pathways/superpathways are cAMP signaling pathway and Serotonergic synapse. Related phenotypes are growth/size/body region and homeostasis/metabolism

Wikipedia : ⁷⁴ Anorgasmia is a type of sexual dysfunction in which a person cannot achieve orgasm despite adequate... more...

Sources

Related Diseases for Inhibited Male Orgasm

Diseases related to Inhibited Male Orgasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 90)

#	Related Disease	Score	Top Affiliating Genes
1	impotence	10.2
2	inhibited female orgasm	10.1	OXT HTR1A
3	animal phobia	10.1	SLC6A4 OXT
4	cyclothymic disorder	10.1	SLC6A4 HTR2C
5	body dysmorphic disorder	10.1	SLC6A4 OXT
6	kleptomania	10.0	SLC6A4 HTR1A
7	atypical depressive disorder	10.0	SLC6A4 HTR1A
8	retrograde amnesia	10.0	SLC6A4 HTR1A
9	pain agnosia	10.0	OXT HTR1A
10	bestiality	10.0	SLC6A3 OXT
11	tic disorder	10.0	SLC6A4 SLC6A3
12	agnosia	10.0	OXT HTR1A
13	diamond-blackfan anemia 5	10.0	SLC6A4 HTR1A
14	melancholia	10.0	SLC6A4 HTR1A
15	schizophreniform disorder	10.0	SLC6A3 HTR2C
16	drug psychosis	10.0	SLC6A3 HTR1A
17	drug-induced mental disorder	10.0	SLC6A3 HTR1A
18	agoraphobia	10.0	SLC6A4 HTR1A
19	lingual-facial-buccal dyskinesia	10.0	SLC6A3 HTR2C
20	amnestic disorder	10.0	OXT OGN HTR1A
21	paranoid schizophrenia	10.0	SLC6A4 HTR1A
22	alcoholic psychosis	10.0	SLC6A4 SLC6A3
23	amphetamine abuse	10.0	SLC6A4 SLC6A3
24	hypoactive sexual desire disorder	10.0	OXT HTR2C HTR1A
25	dissociative disorder	9.9	SLC6A4 OXT OGN
26	withdrawal disorder	9.9	SLC6A3 HTR1A
27	migraine without aura	9.9	SLC6A4 HTR1A
28	heroin dependence	9.9	SLC6A4 SLC6A3
29	somatization disorder	9.9	SLC6A4 OXT HTR1A
30	neurotic disorder	9.9	SLC6A4 OXT HTR1A
31	depression	9.9	SLC6A4 HTR2C HTR1A
32	bulimia nervosa	9.9	SLC6A4 OXT HTR2C
33	acute stress disorder	9.9	SLC6A4 OXT HTR1A
34	phobia, specific	9.9	SLC6A4 OXT HTR1A
35	serotonin syndrome	9.9	SLC6A4 OXT HTR1A
36	opiate dependence	9.9	SLC6A4 SLC6A3
37	alexithymia	9.9	SLC6A4 OXT HTR1A
38	reticuloendotheliosis, x-linked	9.9	RELA REL
39	social phobia	9.9	SLC6A4 OXT HTR1A
40	postpartum depression	9.9	SLC6A4 OXT HTR1A
41	bruxism	9.8	SLC6A4 HTR2C HTR1A
42	bipolar i disorder	9.8	SLC6A4 HTR2C HTR1A
43	delusional disorder	9.8	SLC6A3 HTR2C HTR1A
44	oppositional defiant disorder	9.8	SLC6A4 SLC6A3 OXT
45	antisocial personality disorder	9.8	SLC6A4 SLC6A3 OXT
46	eating disorder	9.7	SLC6A4 SLC6A3 HTR2C
47	pathological gambling	9.7	SLC6A4 SLC6A3 HTR1A
48	cocaine abuse	9.7	SLC6A4 SLC6A3
49	migraine with aura	9.7	SLC6A4 SLC6A3 HTR2C
50	generalized anxiety disorder	9.7	SLC6A4 SLC6A3 HTR1A

Graphical network of the top 20 diseases related to Inhibited Male Orgasm:

Sources

Symptoms & Phenotypes for Inhibited Male Orgasm

MGI Mouse Phenotypes related to Inhibited Male Orgasm:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	growth/size/body region	MP:0005378	9.8	HTR2C OGN OXT REL RELA SLC6A3
2	homeostasis/metabolism	MP:0005376	9.76	HTR1A HTR2C OGN OXT REL RELA
3	integument	MP:0010771	9.5	HTR2C OGN OXT REL RELA SLC6A3
4	nervous system	MP:0003631	9.17	HTR1A HTR2C OXT REL RELA SLC6A3

Sources

Drugs & Therapeutics for Inhibited Male Orgasm

Search Clinical Trials , NIH Clinical Center for Inhibited Male Orgasm

Sources

Genetic Tests for Inhibited Male Orgasm

Sources

Anatomical Context for Inhibited Male Orgasm

Sources

Publications for Inhibited Male Orgasm

Articles related to Inhibited Male Orgasm:

(show all 15)

#	Title	Authors	PMID	Year
1	Cabergoline in the Treatment of Male Orgasmic Disorder-A Retrospective Pilot Analysis. ⁶¹	Hollander AB...Lipshultz LI	26944776	2016
2	Sexual dysfunction--a silent hurt: issues on treatment awareness. ⁶¹	Adegunloye OA...Ezeoke GG	21091876	2011
3	Sexual dysfunction among secondary school teachers in Ilorin, Nigeria. ⁶¹	Adegunloye OA...Adelekan ML	20345733	2010
4	Comments on "Considerations for a better definition of male orgasmic disorder in DSM V". ⁶¹	Wylie K...Perelman MA	20492419	2010
5	Considerations for a better definition of male orgasmic disorder in DSM V. ⁶¹	Segraves RT	20492418	2010
6	Male anorgasmia treated with oxytocin. ⁶¹	IsHak WW...Peters A	18086171	2008
7	Retarded ejaculation - a review. ⁶¹	Richardson D...Goldmeier D	16509998	2006
8	Retarded ejaculation in men: an overview of psychological and neurobiological insights. ⁶¹	Waldinger MD...Schweitzer DH	15937707	2005
9	Prevalence of sexual dysfunctions: results from a decade of research. ⁶¹	Simons JS...Carey MP	11329727	2001
10	Chronic renal failure and sexual functioning: clinical status versus objectively assessed sexual response. ⁶¹	Toorians AW...Everaerd W	9430867	1997
11	Resolution of erectile dysfunction and inhibited male orgasm in a single homosexual male and transfer of inhibited male orgasm cure to his partner: a case report. ⁶¹	Garippa PA...Sanders N	9230493	1997
12	Low-dose imipramine for thioridazine-induced male orgasmic disorder. ⁶¹	Aizenberg D...Weizman A	8880656	1996
13	Sexual dysfunction, Part II: Diagnosis, management, and prognosis. ⁶¹	Halvorsen JG...Metz ME	1575070	1992
14	Incidence and prevalence of the sexual dysfunctions: a critical review of the empirical literature. ⁶¹	Spector IP...Carey MP	2205172	1990
15	The epidemiology of the DSM-III psychosexual dysfunctions. ⁶¹	Nathan SG	3493350	1986

Sources

Genes for Inhibited Male Orgasm

Genes related to Inhibited Male Orgasm (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	OGN	Osteoglycin	Protein Coding	5.94	DISEASES inferred ¹⁵
2	OXT	Oxytocin/Neurophysin I Prepropeptide	Protein Coding	5.42	DISEASES inferred ¹⁵
3	HTR2C	5-Hydroxytryptamine Receptor 2C	Protein Coding	4.78	DISEASES inferred ¹⁵
4	HTR1A	5-Hydroxytryptamine Receptor 1A	Protein Coding	4.39	DISEASES inferred ¹⁵
5	SLC6A4	Solute Carrier Family 6 Member 4	Protein Coding	4.22	DISEASES inferred ¹⁵
6	SLC6A3	Solute Carrier Family 6 Member 3	Protein Coding	4.2	DISEASES inferred ¹⁵
7	REL	REL Proto-Oncogene, NF-KB Subunit	Protein Coding	4.14	DISEASES inferred ¹⁵
8	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	4.08	DISEASES inferred ¹⁵

Sources

Variations for Inhibited Male Orgasm

Sources

Expression for Inhibited Male Orgasm

Search GEO for disease gene expression data for Inhibited Male Orgasm.

Sources

Pathways for Inhibited Male Orgasm

Pathways related to Inhibited Male Orgasm according to GeneCards Suite gene sharing:

(show all 15)

#	Super pathways	Score	Top Affiliating Genes
1	cAMP signaling pathway ³⁶	11.88	RELA OXT HTR1A
2	Serotonergic synapse ³⁶	11.39	SLC6A4 HTR2C HTR1A
3	Photodynamic therapy-induced NF-kB survival signaling ¹ Show member pathways Immune response MIF-mediated glucocorticoid regulation ²³	11.35	RELA REL
4	Transcription_NF-kB signaling pathway ²³	11.27	RELA REL
5	Proteolysis Putative SUMO-1 pathway ²³ Show member pathways DNA damage Role of SUMO in p53 regulation ²³	11.26	RELA REL
6	Cellular Transformation by HTLV1 ⁶³ Show member pathways Activation of NF-KappaB by PKR ⁶³	11.22	RELA REL
7	Tacrolimus/Cyclosporine Pathway, Pharmacodynamics ⁶⁰	11.14	RELA REL
8	DNA damage_ATM/ATR regulation of G1/S checkpoint ²³	11.12	RELA REL
9	Monoamine Transport ¹ Show member pathways Serotonin Transporter Activity ¹	11.09	SLC6A4 SLC6A3
10	Development_Glucocorticoid receptor signaling ²³	11.05	RELA REL
11	Immune response_IL-6 signaling pathway ²³	10.92	RELA REL
12	Neurotransmitter Clearance In The Synaptic Cleft ⁶⁵ Show member pathways Dopamine clearance from the synaptic cleft ⁶⁵ Enzymatic degradation of dopamine by COMT ⁶⁵ Enzymatic degradation of Dopamine by monoamine oxidase ⁶⁵ Metabolism of serotonin ⁶⁵ Serotonin clearance from the synaptic cleft ⁶⁵	10.72	SLC6A4 SLC6A3
13	Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics ⁶⁰	10.58	SLC6A4 HTR2C HTR1A
14	Atypical NF-kappaB pathway ¹	10.4	RELA REL
15	Methylphenidate Pathway, Pharmacodynamics ⁶⁰ Show member pathways Dopamine receptors ⁶⁵	10.16	SLC6A4 SLC6A3 HTR1A

Sources

GO Terms for Inhibited Male Orgasm

Cellular components related to Inhibited Male Orgasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	integral component of presynaptic membrane	GO:0099056	9.16	SLC6A4 SLC6A3
2	integral component of postsynaptic membrane	GO:0099055	8.96	SLC6A4 SLC6A3
3	synapse	GO:0045202	8.92	SLC6A4 RELA HTR2C HTR1A

Biological processes related to Inhibited Male Orgasm according to GeneCards Suite gene sharing:

(show all 18)

#	Name	GO ID	Score	Top Affiliating Genes
1	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	GO:0007187	9.58	HTR2C HTR1A
2	response to organic cyclic compound	GO:0014070	9.58	SLC6A3 RELA OXT
3	response to cytokine	GO:0034097	9.57	RELA REL
4	social behavior	GO:0035176	9.56	SLC6A4 OXT
5	neurotransmitter transport	GO:0006836	9.55	SLC6A4 SLC6A3
6	response to cocaine	GO:0042220	9.54	SLC6A3 OXT
7	response to progesterone	GO:0032570	9.52	RELA OXT
8	G protein-coupled serotonin receptor signaling pathway	GO:0098664	9.51	HTR2C HTR1A
9	behavioral fear response	GO:0001662	9.49	HTR2C HTR1A
10	vasoconstriction	GO:0042310	9.48	SLC6A4 HTR1A
11	behavior	GO:0007610	9.46	HTR2C HTR1A
12	response to drug	GO:0042493	9.46	SLC6A4 SLC6A3 RELA HTR2C
13	neurotransmitter biosynthetic process	GO:0042136	9.43	SLC6A4 SLC6A3
14	regulation of dopamine metabolic process	GO:0042053	9.37	SLC6A3 HTR1A
15	cellular response to stress	GO:0033554	9.32	RELA REL
16	monoamine transport	GO:0015844	9.26	SLC6A4 SLC6A3
17	sperm ejaculation	GO:0042713	8.96	SLC6A4 OXT
18	response to cAMP	GO:0051591	8.8	SLC6A3 RELA OXT

Molecular functions related to Inhibited Male Orgasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	G protein-coupled serotonin receptor activity	GO:0004993	9.26	HTR2C HTR1A
2	neurotransmitter transporter activity	GO:0005326	9.16	SLC6A4 SLC6A3
3	monoamine transmembrane transporter activity	GO:0008504	8.96	SLC6A4 SLC6A3
4	serotonin binding	GO:0051378	8.8	SLC6A4 HTR2C HTR1A

Sources

Sources for Inhibited Male Orgasm

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GARD

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MedlinePlus Genetics

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 05-Mar-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia