Aliases & Classifications for Inner Ear Disease

MalaCards integrated aliases for Inner Ear Disease:

Name: Inner Ear Disease 12 15
Labyrinthine Dysfunction 12 15 73
Abnormality of the Inner Ear 6
Labyrinthine Disorder 73
Diseases of Inner Ear 73
Labyrinthine Disease 12
Labyrinth Diseases 44

Classifications:



Summaries for Inner Ear Disease

MalaCards based summary : Inner Ear Disease, also known as labyrinthine dysfunction, is related to autoimmune inner ear disease and auditory system disease, and has symptoms including earache and vertigo. An important gene associated with Inner Ear Disease is FGF3 (Fibroblast Growth Factor 3), and among its related pathways/superpathways are Interleukin-4 and 13 signaling and TNF signaling pathway. The drugs Betahistine and Histamine have been mentioned in the context of this disorder. Affiliated tissues include testes, bone and brain, and related phenotypes are homeostasis/metabolism and cardiovascular system

Wikipedia : 76 The inner ear (internal ear, auris interna) is the innermost part of the vertebrate ear. In vertebrates,... more...

Related Diseases for Inner Ear Disease

Diseases related to Inner Ear Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 96)
# Related Disease Score Top Affiliating Genes
1 autoimmune inner ear disease 34.7 MMP9 MPO TIMP1 TNF
2 auditory system disease 28.4 ATP6V1B1 COCH GJB2 GJB3 GJB6 KCNQ4
3 bilateral hyperactive labyrinth 11.2
4 unilateral hyperactive labyrinth 11.2
5 bilateral hypoactive labyrinth 11.2
6 unilateral hypoactive labyrinth 11.0
7 otodental dysplasia 11.0 FADD FGF3
8 tietz albinism-deafness syndrome 11.0
9 usher syndrome 11.0
10 deafness, autosomal dominant 24 10.9 GJB2 GJB6
11 hypotrichosis-deafness syndrome 10.9 GJB2 GJB3
12 chronic venous leg ulcers 10.8 MMP9 TIMP1
13 microscopic polyangiitis 10.8 MPO TNF
14 diabetic foot ulcers 10.8 MMP9 TIMP1
15 meniere disease 10.8
16 usher syndrome, type i 10.8
17 usher syndrome, type iiia 10.8
18 deafness, congenital, with inner ear agenesis, microtia, and microdontia 10.8
19 mondini dysplasia 10.8
20 superior semicircular canal dehiscence 10.8
21 microcystic meningioma 10.8 GJB2 MMP9 TIMP1
22 deafness, autosomal recessive 93 10.8 GJB2 GJB3
23 ear malformation 10.8 FGF3 GJB2 SLC26A4
24 pleural tuberculosis 10.7 B2M TIMP1 TNF
25 post-transplant lymphoproliferative disease 10.7 B2M FADD TNF
26 central nervous system tuberculosis 10.7 GJB6 MMP9 TIMP1
27 spondylarthropathy 10.7 B2M TNF
28 respiratory system disease 10.7 MMP9 MPO TNF
29 relapsing-remitting multiple sclerosis 10.7 MMP9 TIMP1 TNF
30 kid syndrome 10.7 GJB2 GJB3 GJB6
31 keratitis, hereditary 10.7 GJB2 GJB6 MMP9
32 pseudoainhum 10.7 GJB2 GJB3 GJB6
33 peritonitis 10.7 B2M MPO TNF
34 deafness, autosomal recessive 1a 10.7 GJB2 GJB3 GJB6
35 kawasaki disease 10.7 MMP9 TIMP1 TNF
36 knuckle pads 10.7 GJB2 GJB3 GJB6
37 periodontitis 10.7 MMP9 TIMP1 TNF
38 appendicitis 10.7 MMP9 MPO TIMP1 TNF
39 membranous nephropathy 10.7 B2M MPO TNF
40 bronchiolitis obliterans 10.7 MMP9 MPO TIMP1 TNF
41 dfnb1 10.7 GJB2 GJB6 MYO7A
42 erythrokeratodermia variabilis et progressiva 1 10.6 GJB2 GJB3 GJB6
43 clouston syndrome 10.6 GJB2 GJB3 GJB6
44 deafness, autosomal recessive 3 10.6 GJB2 MYO7A
45 auditory neuropathy spectrum disorder 10.6 MT-RNR1 MYO7A
46 deafness, autosomal recessive 28 10.6 GJB2 GJB3
47 deafness, autosomal dominant 36 10.6 GJB2 MT-RNR1 SLC26A4
48 pulmonary disease, chronic obstructive 10.6 MMP9 MPO TIMP1 TNF
49 congenital cytomegalovirus 10.6 GJB2 GJB6 MT-RNR1
50 interstitial lung disease 10.6 MMP9 TIMP1 TNF

Comorbidity relations with Inner Ear Disease via Phenotypic Disease Network (PDN):


Hypertension, Essential Ischemic Heart Disease
Labyrinthitis Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Inner Ear Disease:



Diseases related to Inner Ear Disease

Symptoms & Phenotypes for Inner Ear Disease

UMLS symptoms related to Inner Ear Disease:


earache, vertigo

MGI Mouse Phenotypes related to Inner Ear Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.27 B2M GJB3 COL4A5 GJB6 FADD MMP9
2 cardiovascular system MP:0005385 10.23 GJB2 B2M GJB3 COL4A5 GJB6 FADD
3 immune system MP:0005387 10.2 GJB3 COL4A5 GJB6 FADD MMP9 FGF3
4 hematopoietic system MP:0005397 10.14 B2M GJB3 COL4A5 FADD MMP9 TIMP1
5 hearing/vestibular/ear MP:0005377 10.13 COCH GJB6 KCNQ4 FGF3 ATP6V1B1 GJB2
6 mortality/aging MP:0010768 10.07 GJB2 B2M GJB3 COL4A5 FADD FGF3
7 nervous system MP:0003631 10 GJB2 B2M GJB6 FADD KCNQ4 MMP9
8 no phenotypic analysis MP:0003012 9.56 GJB2 GJB3 GJB6 FADD FGF3 MYH9
9 reproductive system MP:0005389 9.28 GJB2 B2M FGF3 SLC26A4 TIMP1 MYO7A

Drugs & Therapeutics for Inner Ear Disease

Drugs for Inner Ear Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 194)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Betahistine Approved, Investigational Phase 4,Not Applicable 5638-76-6 2366
2
Histamine Approved, Investigational Phase 4,Phase 3,Not Applicable 75614-87-8, 51-45-6 774
3
Dimenhydrinate Approved Phase 4,Phase 3 523-87-5 441281
4 Piracetam Approved, Investigational Phase 4 7491-74-9
5
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
6
Metoclopramide Approved, Investigational Phase 4 364-62-5 4168
7
Calcium Carbonate Approved, Investigational Phase 4 471-34-1
8
Ethanol Approved Phase 4 64-17-5 702
9
Glycerol Approved, Investigational Phase 4 56-81-5 753
10
Phenol Approved, Experimental Phase 4,Not Applicable 108-95-2 996
11
Thymol Approved Phase 4 89-83-8 6989
12
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3 83-43-2 6741
13
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3 50-24-8 5755
14
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
15
Glucosamine Approved, Investigational, Nutraceutical Phase 4 3416-24-8 439213
16
Caffeine Approved, Nutraceutical Phase 4 58-08-2 2519
17
Ergocalciferol Approved, Nutraceutical Phase 4 50-14-6 5280793
18
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4 1406-16-2
19
Vitamin D3 Approved, Nutraceutical Phase 4 67-97-0 6221 5280795
20
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3 59-30-3 6037
21
Niacin Approved, Investigational, Nutraceutical Phase 4 59-67-6 938
22
Nicotinamide Approved, Investigational, Nutraceutical Phase 4 98-92-0 936
23
Tocopherol Approved, Investigational, Nutraceutical Phase 4 1406-66-2 14986
24
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4 59-02-9 14985
25 Anticoagulants Phase 4
26 Antimetabolites Phase 4,Phase 3
27 Fibrinolytic Agents Phase 4
28 Glucuronyl glucosamine glycan sulfate Phase 4
29 Hypoglycemic Agents Phase 4
30 Hypolipidemic Agents Phase 4
31 Lipid Regulating Agents Phase 4
32 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
33 Pharmaceutical Solutions Phase 4,Phase 2
34
Histamine Phosphate Phase 4,Phase 3,Not Applicable 51-74-1 65513
35 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
36 Vasodilator Agents Phase 4,Phase 2,Phase 1,Not Applicable
37 Central Nervous System Stimulants Phase 4
38 Phosphodiesterase Inhibitors Phase 4,Phase 2,Not Applicable
39 Purinergic P1 Receptor Antagonists Phase 4
40 Antiemetics Phase 4,Phase 2,Phase 3,Not Applicable
41 Autonomic Agents Phase 4,Phase 2,Phase 3,Not Applicable
42 Gastrointestinal Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
43 Histamine Antagonists Phase 4,Phase 3,Not Applicable
44 Histamine H1 Antagonists Phase 4,Phase 3,Not Applicable
45 Dopamine Agents Phase 4
46 Dopamine Antagonists Phase 4
47 Dopamine D2 Receptor Antagonists Phase 4
48 Antacids Phase 4,Phase 1,Phase 2
49 Anti-Ulcer Agents Phase 4,Phase 1,Phase 2
50 Bone Density Conservation Agents Phase 4

Interventional clinical trials:

(show top 50) (show all 187)
# Name Status NCT ID Phase Drugs
1 Effects on the Diagnostic Accuracy of Magnetic Imaging Angiographies of the Supra-Aortic Vessels by Three Different Magnetic Resonance Contrast Agents in Patients Unknown status NCT00132223 Phase 4 Contrast agent
2 Isobide Solution and Meniace Tablets Compared to Monotherapy With Meniace Tablets Completed NCT02718846 Phase 4 Meniace;Isobide
3 Efficacy of Local Overpressure Treatment for Meniere's Disease Completed NCT00831688 Phase 4
4 Effects of Betaserc on Vestibular Compensation in Patients Suffering From Disabling Meniere's Disease and Having Undergone Vestibular Neurotomy Completed NCT00160238 Phase 4 Betahistine 24 mg bid (Betaserc)
5 Effect of Caffeine Intake in Vestibular Function Completed NCT02825199 Phase 4
6 Comparison of Efficacy Between Piracetam and Dimenhydrinate in Patients With Peripheral Vertigo Completed NCT01890538 Phase 4 Administration of 100 mg dimenhydrinate intravenous;2 g piracetam intravenous
7 Comparison of Efficacy Dimenhydrinate and Metoclopramide in the Treatment of Nausea Due to Vertigo Completed NCT02253524 Phase 4 Dimenhydrinate;Metoclopramide
8 Efficacy of Vitamin D and Calcium Supplementation on the Prevention of Recurrences in BPPV Completed NCT02031692 Phase 4 400IU cholecalciferol and 500mg of elemental calcium as calcium carbonate
9 Effect of Stellate Ganglion Block on Meniere's Disease Completed NCT01574313 Phase 4 0.25mg, fludiazine;25mg cephadol@ (diphenidol);200mg kentons@ (tocopherol nicotinate).
10 Chlorobutanol, Potassium Carbonate, and Irrigation in Cerumen Removal Completed NCT00765635 Phase 4 drops intilation (Taponoto ® );drops intilation (Otocerum®);drops intilation (Placebo)
11 Evaluation of Inner Ear and Brain Structures With Contrast-enhanced MRI in Patients With Meniere's Disease Recruiting NCT02530931 Phase 4 Gadolinium
12 Evaluation of Inner Ear and Brain Structures With Contrast-enhanced MRI in Healthy Subjects (HYDROPS) Recruiting NCT02529475 Phase 4 Gadoteric acid
13 Acute Unilateral Vestibulopathy and Corticosteroid Treatment Recruiting NCT02912182 Phase 4 Betamethasone;Placebo;Prednisolone
14 A Study To Evaluate The Efficacy And Safety Of Betahistine Mesilate In The Treatment Of Patients With Vertigo Caused By Cerebral Infarction In Posterior Circulation Withdrawn NCT00474409 Phase 4 Merislon
15 Efficacy of Antiviral Medications in Controlling Vertigo Attacks of Patients With Meniere's Disease Unknown status NCT01729767 Phase 2, Phase 3 Acyclovir;Placebo
16 Conventional Versus Virtual Reality Based Vestibular Rehabilitation Completed NCT01442623 Phase 2, Phase 3
17 Study of Lamotrigine to Treat Ménière's Disease Completed NCT02158585 Phase 3 Lamotrigine;Placebo
18 Study of OTO-104 in Subjects With Unilateral Meniere's Disease Completed NCT02612337 Phase 3 OTO-104;Placebo
19 Clinical Trial of Traditional Chinese Diaoshi Jifa Therapy of Meniere's Disease Completed NCT01454726 Phase 3
20 Transtympanic Gentamicin vs. Steroids in Refractory Meniere's Disease Completed NCT00802529 Phase 2, Phase 3 Methylprednisolone;Gentamicin
21 The Treatment of Posterior Semicircular Canal Benign Paroxysmal Positional Vertigo Completed NCT02029508 Phase 3
22 Promethazine vs. Lorazepam for Treatment of Vertigo Completed NCT01827293 Phase 3 Promethazine;Lorazepam
23 Treatment of Geotropic Horizontal Canal Benign Paroxysmal Positional Vertigo Completed NCT01366430 Phase 3
24 Treatment of Apogeotropic Horizontal Canal Benign Paroxysmal Positional Vertigo Completed NCT00810641 Phase 3
25 Canalith Repositioning Procedure for BPPV in Primary Care Completed NCT00182273 Phase 3
26 Effects of Prismatic Spectacle Lenses on Symptoms of Dizziness, Headache and Anxiety as Caused by Vertical Heterophoria Completed NCT00785135 Phase 3
27 Non Inferiority of Meclin® (Meclizine Chlorhydrate) Versus Dramin® (Dimenhydrinate) in Control of Acute Vertigo Symptoms From Peripheral Origin Recruiting NCT02112578 Phase 3 Meclizine;Dimenhydrinate
28 Rizatriptan for Episodic Dizziness in Vestibular Migraine Recruiting NCT02447991 Phase 2, Phase 3 Rizatriptan;Placebo
29 Caroverin and Inner Ear Diseases Suspended NCT01174979 Phase 3 Caroverin
30 Autoimmunity in Inner Ear Disease Terminated NCT00000361 Phase 3 Corticosteroids;Methotrexate
31 A 6-Month Extension Study of OTO-104 in Meniere's Disease Terminated NCT02768662 Phase 3 OTO-104
32 Study of OTO-104 in Subjects With Unilateral Meniere's Disease Terminated NCT02717442 Phase 3 OTO-104;Placebo
33 A 6-Month Extension Study of OTO-104 in Meniere's Disease Terminated NCT02706730 Phase 3 OTO-104
34 Famvir for Treatment of Hearing in Unilateral Meniere's Disease Terminated NCT01526408 Phase 3 Famciclovir;Placebo
35 Visual Feedback Goggle for Positional Vertigo Treatment Unknown status NCT00729885 Phase 1, Phase 2
36 Latanoprost for the Treatment of Menière's Disease Unknown status NCT01973114 Phase 2 Latanoprost
37 Efficacy of Extended-release, Once Daily Tramadol for Post Operative Analgesia in Shoulder Arthroscopy Unknown status NCT02247648 Phase 2 tramadol;Placebo
38 The Effects of Gevokizumab in Corticosteroid-resistant Subjects With Autoimmune Inner Ear Disease Completed NCT01950312 Phase 2 gevokizumab
39 A Clinical Trial of Anakinra for Steroid-Resistant Autoimmune Inner Ear Disease Completed NCT01267994 Phase 1, Phase 2 Anakinra
40 Study to Evaluate SPI-1005 in Adults With Meniere's Disease Completed NCT02603081 Phase 1, Phase 2 SPI-1005
41 A 1-Year Safety Study of OTO-104 in Subjects With Unilateral Meniere's Disease Located in United Kingdom Completed NCT02265393 Phase 2 OTO-104;Placebo
42 OTO-104 for the Treatment of Meniere's Disease Completed NCT01412177 Phase 2 OTO-104;Placebo
43 Sildenafil For Meniere's Disease Completed NCT00145483 Phase 2 Sildenafil
44 A Clinical Trial To Evaluate Efficacy And Safety Of Levophencynonate Hydrochloride In Patient With Vertigo Completed NCT02299804 Phase 2 Levophencynonate Hydrochloric;Placebo
45 Treatment of Apogeotropic Horizontal Canal Benign Paroxysmal Positional Vertigo Completed NCT02046980 Phase 2
46 Effect of V0251 in Acute Vertigo Completed NCT01583738 Phase 2 V0251;placebo
47 Prednisone Treatment for Vestibular Neuronitis Completed NCT00271791 Phase 2 Prednisone;Prednisone
48 Treatments for Benign Paroxysmal Positional Vertigo (BPPV) Completed NCT00000359 Phase 2
49 A Trial of Booklet Based Self Management of Dizziness Completed NCT00732797 Phase 2
50 SPI-1005 for the Treatment of Patients With Meniere's Disease Enrolling by invitation NCT03325790 Phase 2 200mg SPI-1005 BID;400mg SPI-1005 BID

Search NIH Clinical Center for Inner Ear Disease

Cochrane evidence based reviews: labyrinth diseases

Genetic Tests for Inner Ear Disease

Anatomical Context for Inner Ear Disease

MalaCards organs/tissues related to Inner Ear Disease:

41
Testes, Bone, Brain, Liver, Eye, Pons, Kidney

Publications for Inner Ear Disease

Articles related to Inner Ear Disease:

(show top 50) (show all 133)
# Title Authors Year
1
Immune-Mediated Inner Ear Disease: Diagnostic and therapeutic approaches. ( 29525415 )
2018
2
Autoimmune Inner Ear Disease: Immune Biomarkers, Audiovestibular Aspects, and Therapeutic Modalities of Cogan's Syndrome. ( 29850616 )
2018
3
Intratympanic gadolinium magnetic resonance imaging supports the role of endolymphatic hydrops in the pathogenesis of immune-mediated inner-ear disease. ( 29888688 )
2018
4
Zebrafish models of human eye and inner ear diseases. ( 28129854 )
2017
5
The Balance of Tissue Inhibitor of Metalloproteinase-1 and Matrix Metalloproteinase-9 in the Autoimmune Inner Ear Disease Patients. ( 28696822 )
2017
6
Autoimmune inner ear disease in a melanoma patient treated with pembrolizumab. ( 26885370 )
2016
7
Chronic cerebrospinal venous insufficiency as a cause of inner ear diseases. ( 27846752 )
2016
8
Anterior Inferior cerebellar artery infarction misdiagnosed as inner ear disease. ( 29553620 )
2016
9
Systematic Review of Treatments for Autoimmune Inner Ear Disease. ( 26485595 )
2015
10
Progression of autoimmune inner ear disease to labyrinthitis ossificans: clinical and radiologic correlation. ( 25738715 )
2015
11
Current understanding of the pathogenesis of autoimmune inner ear disease: a review. ( 25847404 )
2015
12
Paraneoplastic syndrome: a masquerade of autoimmune inner ear disease. ( 25427223 )
2015
13
N-Acetylcysteine attenuates tumor necrosis factor alpha levels in autoimmune inner ear disease patients. ( 26392121 )
2015
14
Diffuse systemic sclerosis presenting as Meniere's disease-like symptoms as part of autoimmune inner ear disease. ( 26040060 )
2015
15
Early efficacy trial of anakinra in corticosteroid-resistant autoimmune inner ear disease. ( 25133431 )
2014
16
The role of intracochlear drug delivery devices in the management of inner ear disease. ( 25347140 )
2014
17
IL-1I^ inhibition in autoimmune inner ear disease: can you hear me now? ( 25133418 )
2014
18
Ocular vestibular evoked myogenic potentials induced by bone-conducted vibration in patients with unilateral inner ear disease. ( 24215219 )
2014
19
Cochlin in autoimmune inner ear disease: Is the search for an inner ear autoantigen over? ( 25199741 )
2014
20
New prospects in the diagnosis and treatment of immune-mediated inner ear disease. ( 25332908 )
2014
21
An open label study to evaluate the safety and efficacy of intratympanic golimumab therapy in patients with autoimmune inner ear disease. ( 25203561 )
2014
22
Cogan's syndrome: an autoimmune inner ear disease. ( 22846458 )
2013
23
Review of the biologic agents used for immune-mediated inner ear disease. ( 22770424 )
2013
24
Innate immune recognition of molds and homology to the inner ear protein, cochlin, in patients with autoimmune inner ear disease. ( 23912888 )
2013
25
Autoimmune inner ear disease preliminary case report: audiometric findings following steroid treatments. ( 23800807 )
2013
26
Developments in delivery of medications for inner ear disease. ( 23560526 )
2013
27
Infliximab for autoimmune inner ear disease: case report and literature review. ( 24125068 )
2013
28
Autoimmune inner ear disease: a retrospective review of forty-seven patients. ( 23817208 )
2013
29
Spectrum of immune-mediated inner ear disease and cochlear implant results. ( 22991211 )
2012
30
Inner ear disease and benign paroxysmal positional vertigo: a critical review of incidence, clinical characteristics, and management. ( 21837242 )
2011
31
Autoimmune inner ear disease in children. ( 21178803 )
2011
32
A pilot study of rituximab in immune-mediated inner ear disease. ( 20980741 )
2011
33
Development of gene therapy for inner ear disease: Using bilateral vestibular hypofunction as a vehicle for translational research. ( 21251965 )
2011
34
IL-1I^ is overexpressed and aberrantly regulated in corticosteroid nonresponders with autoimmune inner ear disease. ( 21199898 )
2011
35
High dose combination pertussis toxin induces autoimmune inner ear disease in Sprague-Dawley rats. ( 21366505 )
2011
36
Auditory and vestibular hair cell stereocilia: relationship between functionality and inner ear disease. ( 21774850 )
2011
37
Extraintestinal Crohn's disease mimicking autoimmune inner ear disease: a histopathological approach. ( 20523038 )
2011
38
Guest editorial: drug delivery for treatment of inner ear disease: current state of knowledge. ( 20215911 )
2010
39
Benign paroxysmal positional vertigo secondary to inner ear disease. ( 20723780 )
2010
40
Cochlear implantation outcomes in patients with autoimmune and immune-mediated inner ear disease. ( 20729775 )
2010
41
Drug delivery for treatment of inner ear disease: current state of knowledge. ( 19952751 )
2010
42
Labyrinthitis ossificans secondary to autoimmune inner ear disease: a previously unreported condition. ( 20416474 )
2010
43
Dr. Takeda's research on MAcniA"re disease and inner ear disease. Preface. ( 20185942 )
2010
44
Cochlear implantation in patients with autoimmune inner ear disease including cogan syndrome: a comparison with age- and sex-matched controls. ( 21082747 )
2010
45
Safety of high-dose corticosteroids for the treatment of autoimmune inner ear disease. ( 19395984 )
2009
46
Immunosuppressive therapy for autoimmune inner ear disease. ( 19885385 )
2009
47
Induction of tolerance by oral administration of beta-tubulin in an animal model of autoimmune inner ear disease. ( 19365153 )
2009
48
The diagnosis of autoimmune inner ear disease: evidence and critical pitfalls. ( 18777037 )
2009
49
Autoimmune inner ear disease: clinical and laboratory findings and treatment outcome. ( 19128599 )
2008
50
Does the serological study for viral infection in autoimmune inner ear disease make sense? ( 18235201 )
2008

Variations for Inner Ear Disease

ClinVar genetic disease variations for Inner Ear Disease:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 46;XX;t(4;15)(q31.3;q15) Translocation Uncertain significance

Expression for Inner Ear Disease

Search GEO for disease gene expression data for Inner Ear Disease.

Pathways for Inner Ear Disease

GO Terms for Inner Ear Disease

Cellular components related to Inner Ear Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 apical plasma membrane GO:0016324 9.46 ATP6V1B1 GJB6 MYO7A SLC26A4
2 gap junction GO:0005921 9.13 GJB2 GJB3 GJB6
3 connexin complex GO:0005922 8.8 GJB2 GJB3 GJB6

Biological processes related to Inner Ear Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 inner ear morphogenesis GO:0042472 9.61 ATP6V1B1 KCNQ4 MYO7A
2 inner ear development GO:0048839 9.54 GJB2 GJB6 MYO7A
3 negative regulation of growth of symbiont in host GO:0044130 9.48 MPO TNF
4 positive regulation of T cell mediated cytotoxicity GO:0001916 9.46 B2M FADD
5 aging GO:0007568 9.46 GJB2 GJB6 MPO TIMP1
6 death-inducing signaling complex assembly GO:0071550 9.4 FADD TNF
7 necroptotic signaling pathway GO:0097527 9.32 FADD TNF
8 positive regulation of receptor binding GO:1900122 9.26 B2M MMP9
9 sensory perception of sound GO:0007605 9.17 ATP6V1B1 COCH GJB2 GJB6 KCNQ4 MYO7A
10 cell communication GO:0007154 9.13 GJB2 GJB3 GJB6

Molecular functions related to Inner Ear Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 9.33 FADD TIMP1 TNF
2 microfilament motor activity GO:0000146 9.26 MYH9 MYO7A
3 gap junction channel activity GO:0005243 8.96 GJB2 GJB3
4 actin-dependent ATPase activity GO:0030898 8.62 MYH9 MYO7A

Sources for Inner Ear Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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