MCID: INS006
MIFTS: 38

Insulin Autoimmune Syndrome

Categories: Rare diseases, Endocrine diseases

Aliases & Classifications for Insulin Autoimmune Syndrome

MalaCards integrated aliases for Insulin Autoimmune Syndrome:

Name: Insulin Autoimmune Syndrome 53 59 73
Hirata Disease 53 59
Insulin Autoimmune Hypoglycemia 53

Characteristics:

Orphanet epidemiological data:

59
insulin autoimmune syndrome
Inheritance: Not applicable; Age of onset: Adult,Elderly;

Classifications:

Orphanet: 59  
Rare endocrine diseases


External Ids:

Orphanet 59 ORPHA411593
ICD10 via Orphanet 34 E16.1
UMLS via Orphanet 74 C0854359
UMLS 73 C0854359

Summaries for Insulin Autoimmune Syndrome

NIH Rare Diseases : 53 Insulin autoimmune syndrome is a rare condition that causes low blood sugar (hypoglycemia). This occurs because the body begins to make a specific kind of protein called antibodies to attack insulin. Insulin is a naturally occurring hormone that is responsible for keeping blood sugar at a normal level. When blood sugar levels get too high, insulin helps to store the sugar for future use. People affected by insulin autoimmune syndrome have antibodies that attack insulin, causing it to work too hard and the level of blood sugar to become too low. Insulin autoimmune syndrome most often begins during adulthood.

MalaCards based summary : Insulin Autoimmune Syndrome, also known as hirata disease, is related to hypoglycemia and hyperinsulinemic hypoglycemia. An important gene associated with Insulin Autoimmune Syndrome is INS (Insulin), and among its related pathways/superpathways are Beta-Adrenergic Signaling and MAPK signaling pathway. Affiliated tissues include t cells and skin, and related phenotypes are hyperinsulinemic hypoglycemia and insulin-resistant diabetes mellitus

Related Diseases for Insulin Autoimmune Syndrome

Graphical network of the top 20 diseases related to Insulin Autoimmune Syndrome:



Diseases related to Insulin Autoimmune Syndrome

Symptoms & Phenotypes for Insulin Autoimmune Syndrome

Human phenotypes related to Insulin Autoimmune Syndrome:

59 32 (show all 13)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 hyperinsulinemic hypoglycemia 59 32 obligate (100%) Obligate (100%) HP:0000825
2 insulin-resistant diabetes mellitus 59 32 hallmark (90%) Very frequent (99-80%) HP:0000831
3 systemic lupus erythematosus 59 32 hallmark (90%) Very frequent (99-80%) HP:0002725
4 increased antibody level in blood 59 32 hallmark (90%) Very frequent (99-80%) HP:0010702
5 autoimmune antibody positivity 59 32 hallmark (90%) Very frequent (99-80%) HP:0030057
6 acanthosis nigricans 59 32 frequent (33%) Frequent (79-30%) HP:0000956
7 weight loss 59 32 frequent (33%) Frequent (79-30%) HP:0001824
8 nonketotic hypoglycemia 59 32 frequent (33%) Frequent (79-30%) HP:0001958
9 fasting hypoglycemia 59 32 frequent (33%) Frequent (79-30%) HP:0003162
10 arthralgia/arthritis 59 32 frequent (33%) Frequent (79-30%) HP:0005059
11 reactive hypoglycemia 59 32 frequent (33%) Frequent (79-30%) HP:0012051
12 insulin resistance 59 Very frequent (99-80%)
13 autoimmunity 59 Frequent (79-30%)

Drugs & Therapeutics for Insulin Autoimmune Syndrome

Search Clinical Trials , NIH Clinical Center for Insulin Autoimmune Syndrome

Genetic Tests for Insulin Autoimmune Syndrome

Anatomical Context for Insulin Autoimmune Syndrome

MalaCards organs/tissues related to Insulin Autoimmune Syndrome:

41
T Cells, Skin

Publications for Insulin Autoimmune Syndrome

Articles related to Insulin Autoimmune Syndrome:

(show top 50) (show all 102)
# Title Authors Year
1
Insulin Autoimmune Syndrome: a rare case of hypoglycaemia resolving with immunosuppression. ( 29588555 )
2018
2
A case report of insulin autoimmune syndrome in a Central European individual. ( 29683798 )
2018
3
Insulin autoimmune syndrome in a pregnant female: A rare case report: Erratum. ( 29369220 )
2018
4
Resolution of Hypoglycemia and Cardiovascular Dysfunction After Rituximab Treatment of Insulin Autoimmune Syndrome. ( 28461453 )
2017
5
Clopidogrel-Induced Insulin Autoimmune Syndrome: A Newly Recognized Cause of Hypoglycemia in a Patient Without Diabetes. ( 29264578 )
2017
6
Insulin autoimmune syndrome (Hirata's disease) in an Italian patient: a case report and review of the literature. ( 28917079 )
2017
7
Immunoadsorption Followed by Rituximab as a Definitive Treatment for Insulin Autoimmune Syndrome (Hirata Syndrome): A Case Report. ( 29282202 )
2017
8
Rare Cause of Recurrent Hypoglycemia: Insulin Autoimmune Syndrome. ( 29318060 )
2017
9
Therapeutic plasma exchange normalizes insulin-mediated response in a child with type 1 diabetes and insulin autoimmune syndrome. ( 28370959 )
2017
10
Insulin autoimmune syndrome in a pregnant female: A rare case report. ( 29390469 )
2017
11
Diagnosis of insulin autoimmune syndrome using polyethylene glycol precipitation and gel filtration chromatography with ex vivo insulin exchange. ( 27588366 )
2016
12
Methimazole-induced insulin autoimmune syndrome. ( 27540463 )
2016
13
Insulin autoimmune syndrome during administration of Clopidogrel. ( 26847582 )
2016
14
Gliclazide - Induced Insulin Autoimmune Syndrome: A Rare Case Report and Review on Literature. ( 28017142 )
2016
15
Insulin Autoimmune Syndrome Accompanied by Multiple Myeloma. ( 27522998 )
2016
16
Insulin autoimmune syndrome in a child with type 1 diabetes: Clinical, immunological, and biochemical correlations. ( 27773181 )
2016
17
The insulin autoimmune syndrome (IAS) as a cause of hypoglycaemia: an update on the pathophysiology, biochemical investigations and diagnosis. ( 27071154 )
2016
18
Novel Management of Insulin Autoimmune Syndrome with Rituximab and Continuous Glucose Monitoring. ( 26982011 )
2016
19
Other Antibodies Resulting in Diabetes Mellitus: Type B Insulin Resistance and Insulin Autoimmune Syndrome ( 26789344 )
2016
20
Human serum albumin: Possible cause of insulin autoimmune syndrome. ( 27804283 )
2016
21
Insulin Autoimmune Syndrome: a rare cause of postprandial hypoglycemia. ( 27855237 )
2016
22
Unusual Manifestations of Essential Monoclonal Gammopathy. II. Simulation of the Insulin Autoimmune Syndrome. ( 26241232 )
2015
23
Rare association of insulin autoimmune syndrome with ankylosing spondylitis. ( 26527431 )
2015
24
Insulin Autoimmune Syndrome: 73 Cases of Clinical Analysis. ( 26315093 )
2015
25
Analytical and clinical challenges in a patient with concurrent type 1 diabetes, subcutaneous insulin resistance and insulin autoimmune syndrome. ( 24711924 )
2014
26
Use of the continuous glucose monitoring system to treat insulin autoimmune syndrome: quantification of glucose excursions and evaluation of treatment efficacy. ( 25077287 )
2014
27
Recurrent hypoglycemia from insulin autoimmune syndrome. ( 23979685 )
2014
28
Hypoglycemic coma due to insulin autoimmune syndrome induced by methimazole: A rare case report. ( 25289063 )
2014
29
An uncommon cause of hypoglycemia: insulin autoimmune syndrome. ( 25060673 )
2014
30
Insulin autoimmune syndrome caused by an adhesive skin patch containing loxoprofen-sodium. ( 24190150 )
2013
31
Insulin glulisine may cause a disease resembling insulin autoimmune syndrome: case report. ( 24265369 )
2013
32
Recurrent Insulin Autoimmune Syndrome Caused by I+-Lipoic Acid in Type 2 Diabetes. ( 24396698 )
2013
33
Insulin autoimmune syndrome (Hirata Disease) in European Caucasians taking I+-lipoic acid. ( 24111525 )
2013
34
Insulin autoimmune syndrome induced by methimazole in a Korean girl with Graves' disease. ( 24904848 )
2013
35
Insulin autoimmune syndrome in a health supplement user: the effectiveness of cornstarch therapy for treating hypoglycemia. ( 23370747 )
2013
36
Insulin autoimmune syndrome induced by methimazole in a patient with Graves' disease. ( 23817229 )
2013
37
A novel atypical presentation of insulin autoimmune syndrome (Hirata's disease) in a child. ( 23843578 )
2013
38
Characterization of insulin antibodies by surface plasmon resonance in two clinical cases: brittle diabetes and insulin autoimmune syndrome. ( 24386337 )
2013
39
Two cases of methimazole-induced insulin autoimmune syndrome in graves' disease. ( 24396652 )
2013
40
Fulminant Type 1 diabetes in a pregnant woman as an initial manifestation of the insulin autoimmune syndrome. ( 22356444 )
2012
41
High prevalence of both anti-insulin and anti-insulin receptor antibodies in Korean patients with insulin autoimmune syndrome. ( 23000370 )
2012
42
Severe hypoglycemia secondary toA methimazole-induced insulin autoimmune syndrome in a 16 year old African-American male. ( 22759245 )
2012
43
Late postprandial hypoglycemia due to bioactive insulin dissociation from autoantibody leading to unconsciousness in a patient with insulin autoimmune syndrome. ( 21325768 )
2011
44
Insulin autoimmune syndrome induced by I+-lipoic acid in a Caucasian woman: case report. ( 21868770 )
2011
45
Insulin autoimmune syndrome: a case associated with HLA-DRB1 polymorphism. ( 21897108 )
2011
46
Drug-induced insulin autoimmune syndrome. ( 19070385 )
2009
47
Insulin autoimmune syndrome in a patient with ANCA-associated glomerulonephritis. ( 21437150 )
2008
48
The novel agent, alpha lipoic acid, can cause the development of insulin autoimmune syndrome. ( 17827827 )
2007
49
Possible relevance of alpha lipoic acid contained in a health supplement in a case of insulin autoimmune syndrome. ( 16963149 )
2007
50
Alpha-lipoic acid and insulin autoimmune syndrome. ( 17586737 )
2007

Variations for Insulin Autoimmune Syndrome

Expression for Insulin Autoimmune Syndrome

Search GEO for disease gene expression data for Insulin Autoimmune Syndrome.

Pathways for Insulin Autoimmune Syndrome

Pathways related to Insulin Autoimmune Syndrome according to GeneCards Suite gene sharing:

(show all 29)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.34 INS INSR
2 12.31 INS INSR
3
Show member pathways
12.27 INS INSR
4
Show member pathways
12.27 INS INSR
5
Show member pathways
12.26 INS INSR
6 12.11 INS INSR
7
Show member pathways
12.09 INS INSR
8
Show member pathways
12.07 INS INSR
9
Show member pathways
12.04 INS INSR
10
Show member pathways
12.01 INS INSR
11
Show member pathways
11.97 INS INSR
12
Show member pathways
11.91 INS INSR
13
Show member pathways
11.8 INS INSR
14
Show member pathways
11.74 INS INSR
15
Show member pathways
11.72 INS INSR
16
Show member pathways
11.68 INS INSR
17
Show member pathways
11.62 INS INSR
18
Show member pathways
11.55 INS INSR
19 11.49 INS INSR
20
Show member pathways
11.44 INS INSR
21 11.25 INS INSR
22 11.14 INS INSR
23 11.07 INS INSR
24 11.01 INS INSR
25 10.89 INS INSR
26 10.89 INS INSR
27
Show member pathways
10.78 INS INSR
28 10.52 INS INSR
29 10.09 INS INSR

GO Terms for Insulin Autoimmune Syndrome

Biological processes related to Insulin Autoimmune Syndrome according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.56 INS INSR
2 carbohydrate metabolic process GO:0005975 9.55 INS INSR
3 positive regulation of cell migration GO:0030335 9.54 INS INSR
4 positive regulation of protein kinase B signaling GO:0051897 9.52 INS INSR
5 positive regulation of MAPK cascade GO:0043410 9.51 INS INSR
6 activation of MAPK activity GO:0000187 9.49 INS INSR
7 glucose homeostasis GO:0042593 9.48 INS INSR
8 insulin receptor signaling pathway GO:0008286 9.46 INS INSR
9 positive regulation of DNA replication GO:0045740 9.43 INS INSR
10 activation of protein kinase B activity GO:0032148 9.4 INS INSR
11 positive regulation of glucose import GO:0046326 9.37 INS INSR
12 positive regulation of mitotic nuclear division GO:0045840 9.32 INS INSR
13 positive regulation of glycolytic process GO:0045821 9.26 INS INSR
14 positive regulation of glycogen biosynthetic process GO:0045725 9.16 INS INSR
15 positive regulation of respiratory burst GO:0060267 8.96 INS INSR
16 neuron projection maintenance GO:1990535 8.62 INS INSR

Molecular functions related to Insulin Autoimmune Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 insulin-like growth factor receptor binding GO:0005159 8.62 INS INSR

Sources for Insulin Autoimmune Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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