MCID: INT283
MIFTS: 31

Integumentary System Cancer

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Integumentary System Cancer

MalaCards integrated aliases for Integumentary System Cancer:

Name: Integumentary System Cancer 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060122

Summaries for Integumentary System Cancer

Disease Ontology : 12 An organ system cancer that is located in the skin, hair and nails.

MalaCards based summary : Integumentary System Cancer is related to giant congenital nevus and brain stem astrocytic neoplasm. An important gene associated with Integumentary System Cancer is IER3IP1 (Immediate Early Response 3 Interacting Protein 1), and among its related pathways/superpathways are Aldosterone synthesis and secretion and Gastric cancer. Affiliated tissues include the skin and skin, and related phenotypes are cellular and behavior/neurological

Related Diseases for Integumentary System Cancer

Diseases related to Integumentary System Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 174)
# Related Disease Score Top Affiliating Genes
1 giant congenital nevus 11.1 HRAS NRAS
2 brain stem astrocytic neoplasm 11.1 CDKN2A TP53
3 calcifying epithelial odontogenic tumor 11.1 PTCH1 TP53
4 inverted transitional papilloma 11.0 CDKN2A KRT7
5 vaginal benign neoplasm 11.0 KRT20 KRT7
6 seminal vesicle adenocarcinoma 11.0 KRT20 KRT7
7 transverse colon cancer 11.0 KRT20 KRT7
8 appendix adenocarcinoma 11.0 KRT20 KRT7
9 ovarian large-cell neuroendocrine carcinoma 11.0 KRT20 KRT7
10 vaginal adenoma 11.0 KRT20 KRT7
11 vaginal tubulovillous adenoma 11.0 KRT20 KRT7
12 eccrine sweat gland neoplasm 11.0 KRT20 KRT7 TP53
13 anal canal carcinoma 11.0 CDKN2A GLI1
14 malignant struma ovarii 11.0 HRAS NRAS PTCH1
15 nipples, supernumerary 11.0 KRT20 PIP
16 malignant spiradenoma 11.0 KRT7 TP53
17 spitz nevus 11.0 CDKN2A HRAS TP53
18 epidermal appendage tumor 11.0 CLEC2A TP53
19 eyelid neoplasm 11.0 KRT20 KRT7
20 bladder carcinoma in situ 11.0 CDKN2A KRT7 TP53
21 glandular cystitis 11.0 KRT20 KRT7
22 mucinous bronchioloalveolar adenocarcinoma 11.0 CDKN2A KRT20 KRT7
23 cystic teratoma 11.0 KRT20 KRT7 TP53
24 melanomatosis 11.0 CDKN2A HRAS NRAS
25 liver angiosarcoma 11.0 HRAS NRAS TP53
26 benign struma ovarii 11.0 HRAS NRAS
27 anus basaloid carcinoma 11.0 KRT7 PTGER4
28 pseudomyxoma peritonei 11.0 KRT20 KRT7 TP53
29 signet ring cell adenocarcinoma 10.9 KRT20 KRT7 TP53
30 necrotizing sialometaplasia 10.9 CDKN2A KRT7 TP53
31 basaloid squamous cell carcinoma 10.9 CDKN2A KRT7 TP53
32 ovarian germ cell teratoma 10.9 KRT7 NRAS
33 krukenberg carcinoma 10.9 KRT20 KRT7
34 prostate squamous cell carcinoma 10.9 HRAS KRT7 TP53
35 bartholin's duct cyst 10.9 PIP TP53
36 bladder adenocarcinoma 10.9 HRAS KRT20 KRT7
37 sweat gland cancer 10.9 KRT20 KRT7 TP53
38 schimmelpenning-feuerstein-mims syndrome 10.9 HRAS NRAS
39 mixed cell type cancer 10.9 HRAS KRT7 TP53
40 ampulla of vater neoplasm 10.9 HRAS KRT20 KRT7
41 adenocarcinoma in situ 10.9 CDKN2A KRT20 KRT7
42 ovary adenocarcinoma 10.9 HRAS KRT7 TP53
43 epithelial-myoepithelial carcinoma 10.9 HRAS KRT7 TP53
44 clear cell adenocarcinoma 10.9 KRT20 KRT7 TP53
45 vulva cancer 10.9 CDKN2A KRT7 TP53
46 skin squamous cell carcinoma 10.9 CDKN2A HRAS TP53
47 penile cancer 10.9 CDKN2A HRAS TP53
48 clear cell basal cell carcinoma 10.9 CLEC2A KRT7
49 polycystic liver disease 1 with or without kidney cysts 10.9 KRT20 KRT7 PTCH1
50 pancreatic mucinous cystadenoma 10.9 HRAS KRT20 KRT7

Graphical network of the top 20 diseases related to Integumentary System Cancer:



Diseases related to Integumentary System Cancer

Symptoms & Phenotypes for Integumentary System Cancer

MGI Mouse Phenotypes related to Integumentary System Cancer:

46 (show all 21)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.44 TP53 XPA TYR CDKN2A KRT7 MAP2K7
2 behavior/neurological MP:0005386 10.41 TP53 XPA TYR HRAS CDKN2A MAP2K7
3 endocrine/exocrine gland MP:0005379 10.34 XPA TYR TP53 CDKN2A HRAS MAP2K7
4 growth/size/body region MP:0005378 10.33 TYR TP53 XPA HRAS CDKN2A GLI1
5 craniofacial MP:0005382 10.32 XPA TYR TP53 GLI1 HRAS NRAS
6 integument MP:0010771 10.32 XPA TYR TP53 MAP2K7 HRAS CDKN2A
7 homeostasis/metabolism MP:0005376 10.29 TYR TP53 XPA HRAS KRT7 CDKN2A
8 immune system MP:0005387 10.27 TP53 XPA TYR CDKN2A MC1R NRAS
9 hematopoietic system MP:0005397 10.26 TP53 XPA CDKN2A MAP2K7 MC1R NRAS
10 neoplasm MP:0002006 10.25 XPA TYR TP53 MAP2K7 GLI1 MC1R
11 digestive/alimentary MP:0005381 10.18 TP53 HRAS CDKN2A GLI1 NRAS PIP
12 embryo MP:0005380 10.17 TYR TP53 CDKN2A GLI1 NRAS MITF
13 no phenotypic analysis MP:0003012 10.14 TYR TP53 GLI1 CDKN2A HRAS NRAS
14 limbs/digits/tail MP:0005371 10.11 TP53 XPA TYR GLI1 NRAS MITF
15 hearing/vestibular/ear MP:0005377 10.08 TP53 TYR MC1R MITF PTCH1 SHH
16 normal MP:0002873 10.07 TP53 TYR HRAS MAP2K7 GLI1 NRAS
17 pigmentation MP:0001186 10.02 XPA TYR TP53 MC1R CDKN2A MITF
18 reproductive system MP:0005389 9.85 TP53 XPA TYR CDKN2A MAP2K7 GLI1
19 renal/urinary system MP:0005367 9.8 TYR TP53 HRAS KRT7 GLI1 SHH
20 skeleton MP:0005390 9.65 TYR TP53 XPA HRAS CDKN2A NRAS
21 vision/eye MP:0005391 9.28 TYR TP53 XPA CDKN2A MAP2K7 NRAS

Drugs & Therapeutics for Integumentary System Cancer

Search Clinical Trials , NIH Clinical Center for Integumentary System Cancer

Genetic Tests for Integumentary System Cancer

Anatomical Context for Integumentary System Cancer

The Foundational Model of Anatomy Ontology organs/tissues related to Integumentary System Cancer:

19
The Skin

MalaCards organs/tissues related to Integumentary System Cancer:

41
Skin

Publications for Integumentary System Cancer

Variations for Integumentary System Cancer

Expression for Integumentary System Cancer

Search GEO for disease gene expression data for Integumentary System Cancer.

Pathways for Integumentary System Cancer

Pathways related to Integumentary System Cancer according to GeneCards Suite gene sharing:

(show all 23)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.9 CDKN2A HRAS MC1R MITF NRAS TYR
2
Show member pathways
12.66 CDKN2A HRAS NRAS SHH TP53
3
Show member pathways
12.51 CDKN2A HRAS MAP2K7 MITF NRAS TP53
4 12.31 CDKN2A HRAS NRAS TP53
5 12.17 CDKN2A HRAS NRAS TP53
6 12.09 HRAS NRAS PTCH1 SHH
7 12.03 CDKN2A HRAS NRAS TP53
8
Show member pathways
12.03 HRAS MAP2K7 NRAS TP53
9 12.02 HRAS NRAS PTCH1 SHH TP53
10 12 CDKN2A GLI1 HRAS MITF NRAS PTCH1
11
Show member pathways
11.97 GLI1 PTCH1 SHH TP53
12 11.79 CDKN2A HRAS NRAS TP53
13 11.75 CDKN2A HRAS NRAS TP53
14 11.56 HRAS NRAS TP53
15 11.42 CDKN2A MAP2K7 TP53
16 11.42 CDKN2A HRAS NRAS TP53
17 11.33 HRAS MAP2K7 TP53
18 11.32 CDKN2A POLH TP53 XPA
19 11.22 GLI1 PTCH1 SHH
20 11.07 HRAS MITF NRAS TP53
21 10.76 HRAS MAP2K7
22 10.72 HRAS NRAS
23 10.49 PTCH1 SHH

GO Terms for Integumentary System Cancer

Biological processes related to Integumentary System Cancer according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.91 CDKN2A GLI1 MITF PTCH1 SHH TP53
2 smoothened signaling pathway GO:0007224 9.67 GLI1 PTCH1 SHH
3 response to UV GO:0009411 9.63 MAP2K7 TYR XPA
4 positive regulation of gene expression GO:0010628 9.63 CDKN2A HRAS MITF PIP SHH TP53
5 dorsal/ventral pattern formation GO:0009953 9.58 GLI1 PTCH1 SHH
6 digestive tract morphogenesis GO:0048546 9.56 GLI1 SHH
7 dorsal/ventral neural tube patterning GO:0021904 9.55 PTCH1 SHH
8 replicative senescence GO:0090399 9.54 CDKN2A TP53
9 UV protection GO:0009650 9.52 MC1R XPA
10 UV-damage excision repair GO:0070914 9.51 MC1R XPA
11 pigmentation GO:0043473 9.5 MC1R MITF TYR
12 smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation GO:0021938 9.37 GLI1 SHH
13 ventral midline development GO:0007418 9.26 GLI1 SHH
14 Ras protein signal transduction GO:0007265 9.26 CDKN2A HRAS NRAS TP53
15 prostate gland development GO:0030850 8.8 GLI1 PTCH1 SHH
16 positive regulation of transcription by RNA polymerase II GO:0045944 10.02 CDKN2A GLI1 HRAS MC1R MITF SHH

Molecular functions related to Integumentary System Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.6 CDKN2A CLEC2A GLI1 HRAS KRT20 KRT7
2 patched binding GO:0005113 9.16 PTCH1 SHH
3 damaged DNA binding GO:0003684 9.13 POLH TP53 XPA

Sources for Integumentary System Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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