MCID: INT379
MIFTS: 29

Integumentary System Disease

Categories: Skin diseases
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Aliases & Classifications for Integumentary System Disease

MalaCards integrated aliases for Integumentary System Disease:

Name: Integumentary System Disease 11 14 16

Classifications:



External Ids:

Disease Ontology 11 DOID:16

Summaries for Integumentary System Disease

Disease Ontology: 11 A disease of anatomical entity that is located in the integumentary system comprising the skin and its appendages.

MalaCards based summary: Integumentary System Disease is related to hair disease and nail disease. An important gene associated with Integumentary System Disease is CCR6 (C-C Motif Chemokine Receptor 6), and among its related pathways/superpathways are T-cell activation SARS-CoV-2 and Interleukin-4 and Interleukin-13 signaling. Affiliated tissues include integumentary system comprising the skin and skin, and related phenotypes are immune system and hematopoietic system

Related Diseases for Integumentary System Disease

Diseases related to Integumentary System Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 838)
# Related Disease Score Top Affiliating Genes
1 hair disease 32.7 TNF IL6 IL17A H2AC18 ERCC6 CD8A
2 nail disease 32.7 TNF IL6 IL17A ICOSLG CD8A CD4
3 skin disease 32.6 TNF SERPINA3 MIR31 MIR21 MIR199A1 MIR17
4 piebald trait 11.1
5 griscelli syndrome 11.1
6 proliferative glomerulonephritis 10.7 ICOSLG H2AC18 CCR6
7 cervix carcinoma 10.7 SERPINA3 MIR21 MIR199A1 MIR146A MIR142 ICOSLG
8 blood platelet disease 10.7 TNF SERPINA3 MIR142 IL6 ICOSLG H2AC18
9 vasculitis 10.7 TNF SERPINA3 IL6 IL17A
10 blood coagulation disease 10.7 TNF SERPINA3 MIR142 IL6 ICOSLG H2AC18
11 peripheral t-cell lymphoma 10.7 MIR21 MIR199A1 MIR17 MIR155 ICOSLG H2AC18
12 mature t-cell and nk-cell lymphoma 10.7 MIR21 MIR199A1 MIR17 MIR155 ICOSLG H2AC18
13 muscle tissue disease 10.7 TNF SERPINA3 MIR21 MIR199A1 MIR142 MIR126
14 lymph node disease 10.7 TNF SERPINA3 IL6 IL17A ICOSLG H2AC18
15 gastrointestinal system benign neoplasm 10.7 SERPINA3 MIR31 MIR21 MIR199A1 MIR17 MIR142
16 secondary progressive multiple sclerosis 10.7 SERPINA3 MIR155 MIR146A MIR142 MIR125A ICOSLG
17 central nervous system vasculitis 10.7 TNF SERPINA3 IL6 IL17A ICOSLG CD8A
18 anterior uveitis 10.7 TNF SERPINA3 IL6 IL17A ICOSLG CD8A
19 bacterial infectious disease 10.7 TNF SERPINA3 MIR21 MIR155 IL6 IL17A
20 panuveitis 10.7 TNF SERPINA3 IL6 IL17A ICOSLG CD8A
21 corneal disease 10.7 TNF SERPINA3 IL6 IL17A H2AC18 ERCC6
22 blood protein disease 10.7 TNF MIR126 IL6 ICOSLG H2AC18 CD8A
23 interstitial lung disease 10.7 TNF SERPINA3 MIR21 MIR199A1 MIR155 MIR142
24 autoimmune disease 10.7 TNF MIR146A IL6 IL4 IL17A ICOSLG
25 thymus gland disease 10.7 MIR142 MIR126 MIR125A ICOSLG H2AC18 CD8A
26 adult t-cell leukemia/lymphoma 10.7 MIR155 MIR142 ICOSLG H2AC18 CD8A CD4
27 thymus cancer 10.7 MIR142 MIR126 MIR125A ICOSLG H2AC18 CD8A
28 intestinal benign neoplasm 10.7 TNF SERPINA3 MIR31 MIR21 MIR199A1 MIR17
29 ovary epithelial cancer 10.7 SERPINA3 MIR21 MIR199A1 MIR17 MIR142 MIR126
30 autoimmune vasculitis 10.7 TNF IL6 IL17A H2AC18 CD8A CD4
31 conjunctivitis 10.7 TNF IL6 IL4
32 covid-19 10.7 TNF IL6 IL4 CCR6
33 chronic conjunctivitis 10.7 TNF IL6 IL4 IL17A ICOSLG CD4
34 salivary gland disease 10.7 TNF SERPINA3 IL6 IL4 ICOSLG H2AC18
35 chromosomal disease 10.7 SERPINA3 MIR21 MIR199A1 MIR17 MIR155 MIR142
36 west nile encephalitis 10.7 TNF IL6 IL4 ICOSLG H2AC18 CD8A
37 autoimmune disease of urogenital tract 10.7 TNF IL17A ICOSLG H2AC18 CD8A CD4
38 chromosomal deletion syndrome 10.7 MIR21 MIR17 MIR142 ICOSLG H2AC18 CD4
39 muscular disease 10.6 TNF SERPINA3 MIR21 MIR199A1 MIR17 MIR142
40 bile duct adenocarcinoma 10.6 SERPINA3 MIR31 MIR21 MIR199A1 MIR17 MIR142
41 skin carcinoma 10.6 TNF MIR31 MIR21 MIR199A1 ICOSLG H2AC18
42 human papillomavirus infectious disease 10.6 MIR31 MIR21 MIR199A1 MIR142 MIR125A ICOSLG
43 autonomic nervous system neoplasm 10.6 MIR31 MIR21 MIR199A1 MIR17 MIR142 MIR126
44 malignant exocrine pancreas neoplasm 10.6 SERPINA3 MIR31 MIR21 MIR199A1 MIR17 MIR142
45 bone remodeling disease 10.6 TNF SERPINA3 MIR199A1 MIR17 MIR142 MIR126
46 peripheral nervous system neoplasm 10.6 SERPINA3 MIR31 MIR21 MIR199A1 MIR17 MIR142
47 heart valve disease 10.6 SERPINA3 MIR21 MIR199A1 MIR17 MIR146A MIR142
48 crescentic glomerulonephritis 10.6 TNF MIR155 IL17A ICOSLG CD8A CD4
49 acute proliferative glomerulonephritis 10.6 TNF MIR155 IL17A ICOSLG CD8A CD4
50 meningitis 10.6 TNF IL6 IL4 IL17A

Graphical network of the top 20 diseases related to Integumentary System Disease:



Diseases related to Integumentary System Disease

Symptoms & Phenotypes for Integumentary System Disease

MGI Mouse Phenotypes related to Integumentary System Disease:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 10 CCR6 CD4 CD8A ERCC6 ICOSLG IL17A
2 hematopoietic system MP:0005397 9.83 CCR6 CD4 CD8A ERCC6 ICOSLG IL17A
3 no phenotypic analysis MP:0003012 9.8 CD4 IL17A IL4 MIR126 MIR146A MIR199A1
4 integument MP:0010771 9.36 CD4 CD8A ERCC6 IL17A IL4 IL6

Drugs & Therapeutics for Integumentary System Disease

Search Clinical Trials, NIH Clinical Center for Integumentary System Disease

Genetic Tests for Integumentary System Disease

Anatomical Context for Integumentary System Disease

Organs/tissues related to Integumentary System Disease:

FMA: Integumentary System Comprising The Skin
MalaCards : Skin

Publications for Integumentary System Disease

Articles related to Integumentary System Disease:

# Title Authors PMID Year
1
Hereditary childhood hearing loss and integumentary system disease. 62
5026034 1972

Variations for Integumentary System Disease

Expression for Integumentary System Disease

Search GEO for disease gene expression data for Integumentary System Disease.

Pathways for Integumentary System Disease

Pathways related to Integumentary System Disease according to GeneCards Suite gene sharing:

(show all 21)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.98 TNF IL4 IL17A CD8A CD4
2 11.86 TNF IL6 IL4 IL17A
3 11.83 TNF IL6 IL4 CD8A CD4
4
Show member pathways
11.81 TNF IL6 IL17A CD4
5
Show member pathways
11.75 IL6 IL4 IL17A CD4
6
Show member pathways
11.67 MIR199A1 MIR17 MIR155
7
Show member pathways
11.65 IL6 CD8A CD4
8 11.65 TNF IL6 CD8A CD4
9 11.61 ICOSLG IL4 IL6 TNF
10 11.57 IL6 IL4 IL17A CD4
11 11.55 TNF IL6 IL4
12
Show member pathways
11.51 TNF IL6 IL4
13 11.4 MIR21 MIR146A IL4
14 11.34 TNF IL4 IL17A CD8A CD4 CCR6
15 11.16 TNF IL6 IL17A
16 11.13 TNF IL6 IL4 IL17A
17 11.02 TNF IL6 IL4 CD4
18 10.89 TNF IL6 IL4 IL17A
19 10.89 TNF MIR21 MIR199A1 MIR155 MIR126 IL6
20 10.68 IL6 IL4
21
Show member pathways
10.26 TNF IL6

GO Terms for Integumentary System Disease

Cellular components related to Integumentary System Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 10.03 TNF IL17A ICOSLG CD8A CD4 CCR6
2 extracellular space GO:0005615 9.91 IL17A IL4 IL6 MIR125A MIR126 MIR142
3 RISC complex GO:0016442 9.55 MIR31 MIR21 MIR199A1 MIR17 MIR155 MIR146A
4 extracellular vesicle GO:1903561 9.46 MIR21 MIR17 MIR126 MIR125A

Biological processes related to Integumentary System Disease according to GeneCards Suite gene sharing:

(show all 26)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 10.31 TNF IL6 IL4 IL17A CD8A CD4
2 miRNA-mediated gene silencing GO:0035195 10.2 MIR125A MIR126 MIR142 MIR146A MIR155 MIR17
3 positive regulation of gene expression GO:0010628 10.17 TNF MIR21 MIR17 MIR146A MIR125A IL6
4 T cell activation GO:0042110 10.11 IL4 ICOSLG CD8A CD4
5 cellular response to lipopolysaccharide GO:0071222 10.02 IL6 MIR146A MIR17 MIR21 TNF
6 negative regulation of gene expression GO:0010629 10.01 TNF MIR21 MIR199A1 MIR17 MIR155 MIR146A
7 positive regulation of protein kinase B signaling GO:0051897 9.99 TNF MIR21 MIR199A1 MIR126
8 positive regulation of mononuclear cell migration GO:0071677 9.92 TNF IL4
9 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.89 TNF MIR21 IL6
10 negative regulation of endothelial cell proliferation GO:0001937 9.88 TNF MIR21 MIR146A
11 positive regulation of vascular associated smooth muscle cell proliferation GO:1904707 9.88 MIR146A MIR17 MIR21 TNF
12 positive regulation of neuroinflammatory response GO:0150078 9.85 TNF MIR142 IL6
13 negative regulation of interleukin-1-mediated signaling pathway GO:2000660 9.8 MIR21 IL6
14 negative regulation of bicellular tight junction assembly GO:1903347 9.78 TNF MIR142
15 positive regulation of cell migration involved in sprouting angiogenesis GO:0090050 9.74 MIR31 MIR146A MIR126
16 positive regulation of sprouting angiogenesis GO:1903672 9.73 MIR31 MIR126 MIR125A
17 positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis GO:1903589 9.7 MIR21 MIR146A MIR126
18 negative regulation of inflammatory response GO:0050728 9.7 MIR31 MIR199A1 MIR146A MIR142 MIR126 IL4
19 miRNA-mediated gene silencing by inhibition of translation GO:0035278 9.65 MIR31 MIR21 MIR17 MIR146A MIR126
20 positive regulation of cardiac muscle hypertrophy in response to stress GO:1903244 9.62 MIR199A1 MIR17
21 negative regulation of vascular associated smooth muscle cell apoptotic process GO:1905460 9.61 MIR21 MIR17
22 positive regulation of metalloendopeptidase activity GO:1904685 9.6 MIR21 MIR17
23 negative regulation of matrix metallopeptidase secretion GO:1904465 9.58 MIR199A1 MIR146A
24 negative regulation of leukocyte adhesion to vascular endothelial cell GO:1904995 9.54 MIR31 MIR146A MIR125A
25 negative regulation of vascular endothelial growth factor production GO:1904046 9.26 MIR199A1 MIR17 MIR146A MIR125A
26 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.23 TNF MIR21 MIR17 IL6 IL17A

Molecular functions related to Integumentary System Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA 3'-UTR binding GO:0003730 9.61 MIR31 MIR21 MIR199A1 MIR17 MIR155 MIR146A
2 mRNA base-pairing translational repressor activity GO:1903231 9.28 MIR31 MIR21 MIR199A1 MIR17 MIR155 MIR146A

Sources for Integumentary System Disease

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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