Integumentary System Disease disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: INT379 MIFTS: 28	Integumentary System Disease Categories: Skin diseases
Genes Tissues Related diseases Publications Pathways Expand all tables

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Aliases & Classifications for Integumentary System Disease

MalaCards integrated aliases for Integumentary System Disease:

Name: Integumentary System Disease ¹² ¹⁵ ¹⁷

Classifications:

MalaCards categories:
Anatomical: Skin diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:16

EFO ¹⁷ EFO_0010285

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Summaries for Integumentary System Disease

Disease Ontology : ¹² A disease of anatomical entity that is located in the integumentary system comprising the skin and its appendages.

MalaCards based summary : Integumentary System Disease is related to hair disease and nail disease. An important gene associated with Integumentary System Disease is CCR6 (C-C Motif Chemokine Receptor 6), and among its related pathways/superpathways are Allograft rejection and T cell receptor signaling pathway. Affiliated tissues include integumentary system comprising the skin and skin, and related phenotype is integument.

Wikipedia : ⁷⁴ The integumentary system comprises the skin and its appendages acting to protect the body from various... more...

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Related Diseases for Integumentary System Disease

Diseases related to Integumentary System Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 571)

#	Related Disease	Score	Top Affiliating Genes
1	hair disease	33.3	TNF IL6 ICOSLG H2AC18 ERCC6 CD8A
2	nail disease	33.2	TNF IL6 IL17A CD8A CD4 CCR6
3	skin disease	33.2	TNF SERPINA3 PRODH MIR31 MIR21 MIR199A1
4	piebald trait	11.2
5	griscelli syndrome	11.2
6	vasculitis	10.9	TNF SERPINA3 IL6 IL17A
7	eye degenerative disease	10.9	SERPINA3 PRODH ICOSLG H2AC18 ERCC6 EPRS1
8	autoimmune disease	10.9	TNF MIR146A IL6 IL17A ICOSLG CCR6
9	ovary epithelial cancer	10.9	SERPINA3 MIR21 MIR199A1 ICOSLG H2AC18 ERCC6
10	chediak-higashi syndrome	10.9	SERPINA3 PRODH ICOSLG H2AC18 CD8A CD4
11	malignant ovarian surface epithelial-stromal neoplasm	10.9	SERPINA3 MIR21 MIR199A1 ICOSLG H2AC18 ERCC6
12	bladder disease	10.9	MIR31 MIR21 MIR199A1 MIR146A MIR142 MIR126
13	central nervous system cancer	10.9	SERPINA3 MIR21 MIR199A1 MIR155 MIR142 MIR126
14	male reproductive system disease	10.9	SERPINA3 PRODH MIR31 MIR21 MIR199A1 MIR146A
15	male reproductive organ cancer	10.9	SERPINA3 PRODH MIR31 MIR21 MIR199A1 MIR146A
16	autonomic nervous system neoplasm	10.9	SERPINA3 MIR21 MIR199A1 MIR142 MIR126 ICOSLG
17	peripheral nervous system neoplasm	10.9	SERPINA3 MIR21 MIR199A1 MIR142 MIR126 ICOSLG
18	cervix disease	10.9	MIR31 MIR21 MIR199A1 MIR155 MIR146A MIR142
19	colonic disease	10.9	SERPINA3 PRODH MIR31 MIR21 MIR199A1 MIR155
20	gastrointestinal system cancer	10.9	SERPINA3 MIR31 MIR21 MIR199A1 MIR155 MIR146A
21	endocrine gland cancer	10.9	SERPINA3 MIR31 MIR21 MIR199A1 MIR155 MIR146A
22	respiratory system cancer	10.9	SERPINA3 MIR31 MIR21 MIR199A1 MIR155 MIR146A
23	blood coagulation disease	10.9	TNF SERPINA3 PRODH IL6 ICOSLG H2AC18
24	mouth disease	10.9	SERPINA3 MIR31 MIR21 MIR199A1 MIR155 MIR142
25	bile duct disease	10.9	TNF SERPINA3 MIR199A1 MIR142 IL6 ICOSLG
26	autoimmune disease of cardiovascular system	10.9	TNF MIR146A IL6 ICOSLG H2AC18 CD4
27	lipid storage disease	10.9	TNF SERPINA3 MIR21 MIR199A1 MIR155 MIR142
28	bile duct adenocarcinoma	10.9	SERPINA3 MIR31 MIR21 MIR199A1 MIR142 H2AC18
29	connective tissue cancer	10.9	SERPINA3 MIR31 MIR21 MIR199A1 MIR155 MIR142
30	cell type benign neoplasm	10.9	SERPINA3 MIR21 MIR199A1 MIR142 MIR126 H2AC18
31	cerebral degeneration	10.9	SERPINA3 PRODH H2AC18 ERCC6 EPRS1 CCR6
32	female reproductive system disease	10.9	SERPINA3 MIR31 MIR21 MIR199A1 MIR155 MIR146A
33	intestinal benign neoplasm	10.9	SERPINA3 MIR21 MIR199A1 MIR142 IL6 H2AC18
34	autoimmune disease of urogenital tract	10.9	IL17A ICOSLG H2AC18 CD8A CD4 CCR6
35	nasopharyngeal disease	10.9	MIR31 MIR21 MIR199A1 MIR142 ICOSLG H2AC18
36	reproductive system disease	10.9	SERPINA3 PRODH MIR31 MIR21 MIR199A1 MIR155
37	laryngeal disease	10.9	MIR31 MIR21 MIR155 MIR142 H2AC18 CCR6
38	thoracic cancer	10.9	SERPINA3 PRODH MIR31 MIR21 MIR199A1 MIR155
39	large intestine cancer	10.9	SERPINA3 MIR31 MIR21 MIR199A1 MIR155 MIR142
40	gastrointestinal system benign neoplasm	10.9	SERPINA3 MIR21 MIR199A1 MIR142 IL6 H2AC18
41	prostate disease	10.9	SERPINA3 MIR31 MIR21 MIR199A1 MIR146A MIR142
42	mycobacterium tuberculosis 1	10.9	TNF SERPINA3 PRODH MIR21 MIR155 IL17A
43	esophageal disease	10.9	MIR31 MIR21 MIR199A1 MIR146A MIR142 MIR126
44	mast cell neoplasm	10.9	SERPINA3 ICOSLG H2AC18 CD8A CD4
45	thyroid gland disease	10.9	SERPINA3 MIR199A1 MIR142 IL6 ICOSLG H2AC18
46	autosomal recessive disease	10.9	SERPINA3 PRODH ICOSLG H2AC18 ERCC6 EPRS1
47	cranial nerve disease	10.9	TNF SERPINA3 IL6 ICOSLG ERCC6 CD4
48	gastrointestinal system disease	10.9	SERPINA3 PRODH MIR31 MIR21 MIR199A1 MIR155
49	human immunodeficiency virus infectious disease	10.9	TNF SERPINA3 ICOSLG H2AC18 CD8A CD4
50	salivary gland disease	10.9	TNF SERPINA3 IL6 ICOSLG H2AC18 CD8A

Graphical network of the top 20 diseases related to Integumentary System Disease:

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Symptoms & Phenotypes for Integumentary System Disease

MGI Mouse Phenotypes related to Integumentary System Disease:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	integument	MP:0010771	9.28	CD4 CD8A EPRS1 ERCC6 IL17A IL6

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Drugs & Therapeutics for Integumentary System Disease

Search Clinical Trials , NIH Clinical Center for Integumentary System Disease

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Genetic Tests for Integumentary System Disease

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Anatomical Context for Integumentary System Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Integumentary System Disease:

¹⁹

Integumentary System Comprising The Skin

MalaCards organs/tissues related to Integumentary System Disease:

⁴⁰

Skin

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Publications for Integumentary System Disease

Articles related to Integumentary System Disease:

#	Title	Authors	PMID	Year
1	Hereditary childhood hearing loss and integumentary system disease. ⁶¹	Konigsmark BW	5026034	1972

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Genes for Integumentary System Disease

Genes related to Integumentary System Disease (0 elite genes):

(show top 50) (show all 103)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	CCR6	C-C Motif Chemokine Receptor 6	Protein Coding	15.38	DISEASES inferred ¹⁵ ¹⁵
2	ICOSLG	Inducible T Cell Costimulator Ligand	Protein Coding	12.53	DISEASES inferred ¹⁵ ¹⁵
3	H2AC18	H2A Clustered Histone 18	Protein Coding	12.01	DISEASES inferred ¹⁵ ¹⁵
4	SERPINA3	Serpin Family A Member 3	Protein Coding	11.94	DISEASES inferred ¹⁵ ¹⁵
5	ERCC6	ERCC Excision Repair 6, Chromatin Remodeling Factor	Protein Coding	11.35	DISEASES inferred ¹⁵ ¹⁵
6	MIR21	MicroRNA 21	RNA Gene	10.38	DISEASES inferred ¹⁵ ¹⁵
7	PRODH	Proline Dehydrogenase 1	Protein Coding	10.34	DISEASES inferred ¹⁵ ¹⁵
8	MIR155	MicroRNA 155	RNA Gene	10.12	DISEASES inferred ¹⁵ ¹⁵
9	MIR146A	MicroRNA 146a	RNA Gene	9.86	DISEASES inferred ¹⁵ ¹⁵
10	MIR142	MicroRNA 142	RNA Gene	9.8	DISEASES inferred ¹⁵ ¹⁵
11	CD4	CD4 Molecule	Protein Coding	9.58	DISEASES inferred ¹⁵
12	MIR31	MicroRNA 31	RNA Gene	9.57	DISEASES inferred ¹⁵ ¹⁵
13	TNF	Tumor Necrosis Factor	Protein Coding	9.54	DISEASES inferred ¹⁵
14	MIR126	MicroRNA 126	RNA Gene	9.4	DISEASES inferred ¹⁵ ¹⁵
15	MIR199A1	MicroRNA 199a-1	RNA Gene	9.4	DISEASES inferred ¹⁵ ¹⁵
16	IL17A	Interleukin 17A	Protein Coding	9.32	DISEASES inferred ¹⁵
17	CD8A	CD8a Molecule	Protein Coding	9.32	DISEASES inferred ¹⁵
18	EPRS1	Glutamyl-Prolyl-TRNA Synthetase 1	Protein Coding	9.28	DISEASES inferred ¹⁵ ¹⁵
19	FLG	Filaggrin	Protein Coding	9.14	DISEASES inferred ¹⁵
20	IL6	Interleukin 6	Protein Coding	9.11	DISEASES inferred ¹⁵
21	IL4	Interleukin 4	Protein Coding	9.11	DISEASES inferred ¹⁵
22	TNFRSF1B	TNF Receptor Superfamily Member 1B	Protein Coding	9.11	DISEASES inferred ¹⁵
23	MIR17	MicroRNA 17	RNA Gene	9.11	DISEASES inferred ¹⁵ ¹⁵
24	CD40LG	CD40 Ligand	Protein Coding	9.03	DISEASES inferred ¹⁵
25	IL10	Interleukin 10	Protein Coding	8.96	DISEASES inferred ¹⁵
26	IL1B	Interleukin 1 Beta	Protein Coding	8.93	DISEASES inferred ¹⁵
27	SERPING1	Serpin Family G Member 1	Protein Coding	8.86	DISEASES inferred ¹⁵
28	SIGLEC5	Sialic Acid Binding Ig Like Lectin 5	Protein Coding	8.86	DISEASES inferred ¹⁵ ¹⁵
29	IL2	Interleukin 2	Protein Coding	8.8	DISEASES inferred ¹⁵
30	MIR125A	MicroRNA 125a	RNA Gene	8.75	DISEASES inferred ¹⁵ ¹⁵
31	DSG1	Desmoglein 1	Protein Coding	8.75	DISEASES inferred ¹⁵
32	KDM4C	Lysine Demethylase 4C	Protein Coding	8.74	DISEASES inferred ¹⁵ ¹⁵
33	CXCL8	C-X-C Motif Chemokine Ligand 8	Protein Coding	8.74	DISEASES inferred ¹⁵
34	IL13	Interleukin 13	Protein Coding	8.73	DISEASES inferred ¹⁵
35	CRP	C-Reactive Protein	Protein Coding	8.73	DISEASES inferred ¹⁵
36	U2AF1	U2 Small Nuclear RNA Auxiliary Factor 1	Protein Coding	8.72	DISEASES inferred ¹⁵ ¹⁵
37	MIR140	MicroRNA 140	RNA Gene	8.69	DISEASES inferred ¹⁵ ¹⁵
38	CTLA4	Cytotoxic T-Lymphocyte Associated Protein 4	Protein Coding	8.66	DISEASES inferred ¹⁵
39	ALB	Albumin	Protein Coding	8.65	DISEASES inferred ¹⁵
40	TP53	Tumor Protein P53	Protein Coding	8.64	DISEASES inferred ¹⁵
41	MIR9-1	MicroRNA 9-1	RNA Gene	8.64	DISEASES inferred ¹⁵ ¹⁵
42	COL17A1	Collagen Type XVII Alpha 1 Chain	Protein Coding	8.64	DISEASES inferred ¹⁵
43	IL5	Interleukin 5	Protein Coding	8.63	DISEASES inferred ¹⁵
44	DSG3	Desmoglein 3	Protein Coding	8.62	DISEASES inferred ¹⁵
45	MIR196A1	MicroRNA 196a-1	RNA Gene	8.6	DISEASES inferred ¹⁵ ¹⁵
46	FOXP3	Forkhead Box P3	Protein Coding	8.45	DISEASES inferred ¹⁵
47	TSLP	Thymic Stromal Lymphopoietin	Protein Coding	8.44	DISEASES inferred ¹⁵
48	MIR483	MicroRNA 483	RNA Gene	8.43	DISEASES inferred ¹⁵ ¹⁵
49	MIR19A	MicroRNA 19a	RNA Gene	8.41	DISEASES inferred ¹⁵ ¹⁵
50	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	8.39	DISEASES inferred ¹⁵

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Variations for Integumentary System Disease

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Expression for Integumentary System Disease

Search GEO for disease gene expression data for Integumentary System Disease.

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Pathways for Integumentary System Disease

Pathways related to Integumentary System Disease according to GeneCards Suite gene sharing:

(show all 11)

#	Super pathways	Score	Top Affiliating Genes
1	Allograft rejection ¹ ³⁶ Show member pathways Antigen processing and presentation ³⁶ Asthma ³⁶ Autoimmune thyroid disease ³⁶ CTL Mediated Apoptosis ⁶³ Graft-versus-host disease ³⁶ Intestinal immune network for IgA production ³⁶ THC Differentiation Pathway ⁶³ Type I diabetes mellitus ³⁶ Viral myocarditis ³⁶	12.62	TNF IL6 IL17A ICOSLG CD8A CD4
2	T cell receptor signaling pathway ³⁶ Show member pathways PD-L1 expression and PD-1 checkpoint pathway in cancer ³⁶ T-Cell antigen Receptor (TCR) Signaling Pathway ¹ T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection ¹	12.42	TNF IL6 IL17A CD8A CD4
3	MicroRNAs in cancer ³⁶	11.92	MIR31 MIR21 MIR199A1 MIR155 MIR146A MIR126
4	Hematopoietic Stem Cells and Lineage-specific Markers ⁶⁴	11.8	TNF IL6 CD8A CD4
5	IL27-mediated signaling events ¹ Show member pathways IL12 Signaling Pathway ⁶⁶ Th1 Differentiation ⁶⁴	11.65	TNF IL6 IL17A CD4
6	Hematopoietic cell lineage ³⁶	11.55	TNF IL6 CD8A CD4
7	Dendritic Cells Developmental Lineage Pathway ⁶⁴	11.33	TNF IL6 CD8A CD4
8	Development and heterogeneity of the ILC family ¹	11.14	TNF IL6 IL17A
9	Cytokines and Inflammatory Response ¹	11.01	TNF IL6 CD4
10	Innate Lymphoid Cells Differentiation ⁶⁴	10.92	TNF IL17A CD8A CD4 CCR6
11	EV release from cardiac cells and their functional effects ¹	10.45	TNF MIR126

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GO Terms for Integumentary System Disease

Cellular components related to Integumentary System Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	external side of plasma membrane	GO:0009897	9.43	TNF IL17A ICOSLG CD8A CD4 CCR6
2	extracellular space	GO:0005615	9.36	TNF SERPINA3 MIR31 MIR21 MIR199A1 MIR155

Biological processes related to Integumentary System Disease according to GeneCards Suite gene sharing:

(show all 30)

#	Name	GO ID	Score	Top Affiliating Genes
1	immune response	GO:0006955	10	TNF IL6 IL17A CD8A CD4 CCR6
2	positive regulation of gene expression	GO:0010628	9.97	TNF MIR21 MIR155 MIR146A IL6 ERCC6
3	positive regulation of ERK1 and ERK2 cascade	GO:0070374	9.93	TNF MIR21 MIR126 CD4
4	cellular response to lipopolysaccharide	GO:0071222	9.9	TNF MIR21 MIR146A IL6
5	positive regulation of protein kinase B signaling	GO:0051897	9.89	TNF MIR21 MIR199A1 MIR126
6	gene silencing by miRNA	GO:0035195	9.87	MIR31 MIR21 MIR199A1 MIR155 MIR146A MIR142
7	positive regulation of angiogenesis	GO:0045766	9.86	MIR31 MIR21 MIR199A1 MIR126
8	humoral immune response	GO:0006959	9.78	TNF IL6 CCR6
9	negative regulation of cell migration involved in sprouting angiogenesis	GO:0090051	9.76	MIR199A1 MIR155 MIR146A
10	miRNA mediated inhibition of translation	GO:0035278	9.76	MIR31 MIR21 MIR155 MIR146A
11	T cell activation	GO:0042110	9.75	ICOSLG CD8A CD4
12	negative regulation of endothelial cell proliferation	GO:0001937	9.72	TNF MIR21 MIR146A
13	positive regulation of cell migration involved in sprouting angiogenesis	GO:0090050	9.71	MIR31 MIR146A MIR126
14	positive regulation of inflammatory response	GO:0050729	9.71	TNF MIR21 MIR155 MIR126
15	positive regulation of sprouting angiogenesis	GO:1903672	9.69	MIR31 MIR155 MIR126
16	positive regulation of cardiac muscle hypertrophy in response to stress	GO:1903244	9.65	MIR199A1 MIR155
17	positive regulation of activated T cell proliferation	GO:0042104	9.65	MIR21 MIR155 ICOSLG
18	negative regulation of interleukin-8 production	GO:0032717	9.64	MIR155 MIR146A
19	negative regulation of lipid storage	GO:0010888	9.64	TNF IL6
20	positive regulation of interleukin-1 beta biosynthetic process	GO:0050725	9.63	TNF IL17A
21	negative regulation of vascular wound healing	GO:0061044	9.62	TNF MIR155
22	negative regulation of regulatory T cell differentiation	GO:0045590	9.62	MIR21 MIR155
23	negative regulation of interleukin-1-mediated signaling pathway	GO:2000660	9.61	MIR21 IL6
24	positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	GO:1903589	9.61	MIR21 MIR146A MIR126
25	negative regulation of bicellular tight junction assembly	GO:1903347	9.57	TNF MIR155
26	negative regulation of inflammatory response	GO:0050728	9.55	MIR31 MIR155 MIR146A MIR142 MIR126
27	positive regulation of leukocyte adhesion to vascular endothelial cell	GO:1904996	9.54	TNF MIR21 IL6
28	positive regulation of neuroinflammatory response	GO:0150078	9.43	TNF MIR142 IL6
29	negative regulation of leukocyte adhesion to vascular endothelial cell	GO:1904995	9.13	MIR31 MIR155 MIR146A
30	positive regulation of cytokine production involved in inflammatory response	GO:1900017	8.92	TNF MIR21 IL6 IL17A

Molecular functions related to Integumentary System Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	mRNA binding involved in posttranscriptional gene silencing	GO:1903231	9.17	MIR31 MIR21 MIR199A1 MIR155 MIR146A MIR142

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