MCID: INT379
MIFTS: 28

Integumentary System Disease

Categories: Skin diseases

Aliases & Classifications for Integumentary System Disease

MalaCards integrated aliases for Integumentary System Disease:

Name: Integumentary System Disease 12 15 17

Classifications:



External Ids:

Disease Ontology 12 DOID:16

Summaries for Integumentary System Disease

Disease Ontology : 12 A disease of anatomical entity that is located in the integumentary system comprising the skin and its appendages.

MalaCards based summary : Integumentary System Disease is related to hair disease and nail disease. An important gene associated with Integumentary System Disease is CCR6 (C-C Motif Chemokine Receptor 6), and among its related pathways/superpathways are Allograft rejection and T cell receptor signaling pathway. Affiliated tissues include integumentary system comprising the skin and skin, and related phenotype is integument.

Wikipedia : 74 The integumentary system comprises the skin and its appendages acting to protect the body from various... more...

Related Diseases for Integumentary System Disease

Diseases related to Integumentary System Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 571)
# Related Disease Score Top Affiliating Genes
1 hair disease 33.3 TNF IL6 ICOSLG H2AC18 ERCC6 CD8A
2 nail disease 33.2 TNF IL6 IL17A CD8A CD4 CCR6
3 skin disease 33.2 TNF SERPINA3 PRODH MIR31 MIR21 MIR199A1
4 piebald trait 11.2
5 griscelli syndrome 11.2
6 vasculitis 10.9 TNF SERPINA3 IL6 IL17A
7 eye degenerative disease 10.9 SERPINA3 PRODH ICOSLG H2AC18 ERCC6 EPRS1
8 autoimmune disease 10.9 TNF MIR146A IL6 IL17A ICOSLG CCR6
9 ovary epithelial cancer 10.9 SERPINA3 MIR21 MIR199A1 ICOSLG H2AC18 ERCC6
10 chediak-higashi syndrome 10.9 SERPINA3 PRODH ICOSLG H2AC18 CD8A CD4
11 malignant ovarian surface epithelial-stromal neoplasm 10.9 SERPINA3 MIR21 MIR199A1 ICOSLG H2AC18 ERCC6
12 bladder disease 10.9 MIR31 MIR21 MIR199A1 MIR146A MIR142 MIR126
13 central nervous system cancer 10.9 SERPINA3 MIR21 MIR199A1 MIR155 MIR142 MIR126
14 male reproductive system disease 10.9 SERPINA3 PRODH MIR31 MIR21 MIR199A1 MIR146A
15 male reproductive organ cancer 10.9 SERPINA3 PRODH MIR31 MIR21 MIR199A1 MIR146A
16 autonomic nervous system neoplasm 10.9 SERPINA3 MIR21 MIR199A1 MIR142 MIR126 ICOSLG
17 peripheral nervous system neoplasm 10.9 SERPINA3 MIR21 MIR199A1 MIR142 MIR126 ICOSLG
18 cervix disease 10.9 MIR31 MIR21 MIR199A1 MIR155 MIR146A MIR142
19 colonic disease 10.9 SERPINA3 PRODH MIR31 MIR21 MIR199A1 MIR155
20 gastrointestinal system cancer 10.9 SERPINA3 MIR31 MIR21 MIR199A1 MIR155 MIR146A
21 endocrine gland cancer 10.9 SERPINA3 MIR31 MIR21 MIR199A1 MIR155 MIR146A
22 respiratory system cancer 10.9 SERPINA3 MIR31 MIR21 MIR199A1 MIR155 MIR146A
23 blood coagulation disease 10.9 TNF SERPINA3 PRODH IL6 ICOSLG H2AC18
24 mouth disease 10.9 SERPINA3 MIR31 MIR21 MIR199A1 MIR155 MIR142
25 bile duct disease 10.9 TNF SERPINA3 MIR199A1 MIR142 IL6 ICOSLG
26 autoimmune disease of cardiovascular system 10.9 TNF MIR146A IL6 ICOSLG H2AC18 CD4
27 lipid storage disease 10.9 TNF SERPINA3 MIR21 MIR199A1 MIR155 MIR142
28 bile duct adenocarcinoma 10.9 SERPINA3 MIR31 MIR21 MIR199A1 MIR142 H2AC18
29 connective tissue cancer 10.9 SERPINA3 MIR31 MIR21 MIR199A1 MIR155 MIR142
30 cell type benign neoplasm 10.9 SERPINA3 MIR21 MIR199A1 MIR142 MIR126 H2AC18
31 cerebral degeneration 10.9 SERPINA3 PRODH H2AC18 ERCC6 EPRS1 CCR6
32 female reproductive system disease 10.9 SERPINA3 MIR31 MIR21 MIR199A1 MIR155 MIR146A
33 intestinal benign neoplasm 10.9 SERPINA3 MIR21 MIR199A1 MIR142 IL6 H2AC18
34 autoimmune disease of urogenital tract 10.9 IL17A ICOSLG H2AC18 CD8A CD4 CCR6
35 nasopharyngeal disease 10.9 MIR31 MIR21 MIR199A1 MIR142 ICOSLG H2AC18
36 reproductive system disease 10.9 SERPINA3 PRODH MIR31 MIR21 MIR199A1 MIR155
37 laryngeal disease 10.9 MIR31 MIR21 MIR155 MIR142 H2AC18 CCR6
38 thoracic cancer 10.9 SERPINA3 PRODH MIR31 MIR21 MIR199A1 MIR155
39 large intestine cancer 10.9 SERPINA3 MIR31 MIR21 MIR199A1 MIR155 MIR142
40 gastrointestinal system benign neoplasm 10.9 SERPINA3 MIR21 MIR199A1 MIR142 IL6 H2AC18
41 prostate disease 10.9 SERPINA3 MIR31 MIR21 MIR199A1 MIR146A MIR142
42 mycobacterium tuberculosis 1 10.9 TNF SERPINA3 PRODH MIR21 MIR155 IL17A
43 esophageal disease 10.9 MIR31 MIR21 MIR199A1 MIR146A MIR142 MIR126
44 mast cell neoplasm 10.9 SERPINA3 ICOSLG H2AC18 CD8A CD4
45 thyroid gland disease 10.9 SERPINA3 MIR199A1 MIR142 IL6 ICOSLG H2AC18
46 autosomal recessive disease 10.9 SERPINA3 PRODH ICOSLG H2AC18 ERCC6 EPRS1
47 cranial nerve disease 10.9 TNF SERPINA3 IL6 ICOSLG ERCC6 CD4
48 gastrointestinal system disease 10.9 SERPINA3 PRODH MIR31 MIR21 MIR199A1 MIR155
49 human immunodeficiency virus infectious disease 10.9 TNF SERPINA3 ICOSLG H2AC18 CD8A CD4
50 salivary gland disease 10.9 TNF SERPINA3 IL6 ICOSLG H2AC18 CD8A

Graphical network of the top 20 diseases related to Integumentary System Disease:



Diseases related to Integumentary System Disease

Symptoms & Phenotypes for Integumentary System Disease

MGI Mouse Phenotypes related to Integumentary System Disease:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.28 CD4 CD8A EPRS1 ERCC6 IL17A IL6

Drugs & Therapeutics for Integumentary System Disease

Search Clinical Trials , NIH Clinical Center for Integumentary System Disease

Genetic Tests for Integumentary System Disease

Anatomical Context for Integumentary System Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Integumentary System Disease:

19
Integumentary System Comprising The Skin

MalaCards organs/tissues related to Integumentary System Disease:

40
Skin

Publications for Integumentary System Disease

Articles related to Integumentary System Disease:

# Title Authors PMID Year
1
Hereditary childhood hearing loss and integumentary system disease. 61
5026034 1972

Variations for Integumentary System Disease

Expression for Integumentary System Disease

Search GEO for disease gene expression data for Integumentary System Disease.

Pathways for Integumentary System Disease

GO Terms for Integumentary System Disease

Cellular components related to Integumentary System Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.43 TNF IL17A ICOSLG CD8A CD4 CCR6
2 extracellular space GO:0005615 9.36 TNF SERPINA3 MIR31 MIR21 MIR199A1 MIR155

Biological processes related to Integumentary System Disease according to GeneCards Suite gene sharing:

(show all 30)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 10 TNF IL6 IL17A CD8A CD4 CCR6
2 positive regulation of gene expression GO:0010628 9.97 TNF MIR21 MIR155 MIR146A IL6 ERCC6
3 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.93 TNF MIR21 MIR126 CD4
4 cellular response to lipopolysaccharide GO:0071222 9.9 TNF MIR21 MIR146A IL6
5 positive regulation of protein kinase B signaling GO:0051897 9.89 TNF MIR21 MIR199A1 MIR126
6 gene silencing by miRNA GO:0035195 9.87 MIR31 MIR21 MIR199A1 MIR155 MIR146A MIR142
7 positive regulation of angiogenesis GO:0045766 9.86 MIR31 MIR21 MIR199A1 MIR126
8 humoral immune response GO:0006959 9.78 TNF IL6 CCR6
9 negative regulation of cell migration involved in sprouting angiogenesis GO:0090051 9.76 MIR199A1 MIR155 MIR146A
10 miRNA mediated inhibition of translation GO:0035278 9.76 MIR31 MIR21 MIR155 MIR146A
11 T cell activation GO:0042110 9.75 ICOSLG CD8A CD4
12 negative regulation of endothelial cell proliferation GO:0001937 9.72 TNF MIR21 MIR146A
13 positive regulation of cell migration involved in sprouting angiogenesis GO:0090050 9.71 MIR31 MIR146A MIR126
14 positive regulation of inflammatory response GO:0050729 9.71 TNF MIR21 MIR155 MIR126
15 positive regulation of sprouting angiogenesis GO:1903672 9.69 MIR31 MIR155 MIR126
16 positive regulation of cardiac muscle hypertrophy in response to stress GO:1903244 9.65 MIR199A1 MIR155
17 positive regulation of activated T cell proliferation GO:0042104 9.65 MIR21 MIR155 ICOSLG
18 negative regulation of interleukin-8 production GO:0032717 9.64 MIR155 MIR146A
19 negative regulation of lipid storage GO:0010888 9.64 TNF IL6
20 positive regulation of interleukin-1 beta biosynthetic process GO:0050725 9.63 TNF IL17A
21 negative regulation of vascular wound healing GO:0061044 9.62 TNF MIR155
22 negative regulation of regulatory T cell differentiation GO:0045590 9.62 MIR21 MIR155
23 negative regulation of interleukin-1-mediated signaling pathway GO:2000660 9.61 MIR21 IL6
24 positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis GO:1903589 9.61 MIR21 MIR146A MIR126
25 negative regulation of bicellular tight junction assembly GO:1903347 9.57 TNF MIR155
26 negative regulation of inflammatory response GO:0050728 9.55 MIR31 MIR155 MIR146A MIR142 MIR126
27 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.54 TNF MIR21 IL6
28 positive regulation of neuroinflammatory response GO:0150078 9.43 TNF MIR142 IL6
29 negative regulation of leukocyte adhesion to vascular endothelial cell GO:1904995 9.13 MIR31 MIR155 MIR146A
30 positive regulation of cytokine production involved in inflammatory response GO:1900017 8.92 TNF MIR21 IL6 IL17A

Molecular functions related to Integumentary System Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA binding involved in posttranscriptional gene silencing GO:1903231 9.17 MIR31 MIR21 MIR199A1 MIR155 MIR146A MIR142

Sources for Integumentary System Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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