Integumentary System Disease disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Integumentary System Disease

MalaCards integrated aliases for Integumentary System Disease:

Name: Integumentary System Disease ¹¹ ¹⁴ ¹⁶

Classifications:

MalaCards categories:
Anatomical: Skin diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹¹ DOID:16

EFO ¹⁶ EFO_0010285

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Summaries for Integumentary System Disease

Disease Ontology: ¹¹ A disease of anatomical entity that is located in the integumentary system comprising the skin and its appendages.

MalaCards based summary: Integumentary System Disease is related to hair disease and nail disease. An important gene associated with Integumentary System Disease is CCR6 (C-C Motif Chemokine Receptor 6), and among its related pathways/superpathways are T-cell activation SARS-CoV-2 and Interleukin-4 and Interleukin-13 signaling. Affiliated tissues include integumentary system comprising the skin and skin, and related phenotypes are immune system and hematopoietic system

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Related Diseases for Integumentary System Disease

Diseases related to Integumentary System Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 838)

#	Related Disease	Score	Top Affiliating Genes
1	hair disease	32.7	TNF IL6 IL17A H2AC18 ERCC6 CD8A
2	nail disease	32.7	TNF IL6 IL17A ICOSLG CD8A CD4
3	skin disease	32.6	TNF SERPINA3 MIR31 MIR21 MIR199A1 MIR17
4	piebald trait	11.1
5	griscelli syndrome	11.1
6	proliferative glomerulonephritis	10.7	ICOSLG H2AC18 CCR6
7	cervix carcinoma	10.7	SERPINA3 MIR21 MIR199A1 MIR146A MIR142 ICOSLG
8	blood platelet disease	10.7	TNF SERPINA3 MIR142 IL6 ICOSLG H2AC18
9	vasculitis	10.7	TNF SERPINA3 IL6 IL17A
10	blood coagulation disease	10.7	TNF SERPINA3 MIR142 IL6 ICOSLG H2AC18
11	peripheral t-cell lymphoma	10.7	MIR21 MIR199A1 MIR17 MIR155 ICOSLG H2AC18
12	mature t-cell and nk-cell lymphoma	10.7	MIR21 MIR199A1 MIR17 MIR155 ICOSLG H2AC18
13	muscle tissue disease	10.7	TNF SERPINA3 MIR21 MIR199A1 MIR142 MIR126
14	lymph node disease	10.7	TNF SERPINA3 IL6 IL17A ICOSLG H2AC18
15	gastrointestinal system benign neoplasm	10.7	SERPINA3 MIR31 MIR21 MIR199A1 MIR17 MIR142
16	secondary progressive multiple sclerosis	10.7	SERPINA3 MIR155 MIR146A MIR142 MIR125A ICOSLG
17	central nervous system vasculitis	10.7	TNF SERPINA3 IL6 IL17A ICOSLG CD8A
18	anterior uveitis	10.7	TNF SERPINA3 IL6 IL17A ICOSLG CD8A
19	bacterial infectious disease	10.7	TNF SERPINA3 MIR21 MIR155 IL6 IL17A
20	panuveitis	10.7	TNF SERPINA3 IL6 IL17A ICOSLG CD8A
21	corneal disease	10.7	TNF SERPINA3 IL6 IL17A H2AC18 ERCC6
22	blood protein disease	10.7	TNF MIR126 IL6 ICOSLG H2AC18 CD8A
23	interstitial lung disease	10.7	TNF SERPINA3 MIR21 MIR199A1 MIR155 MIR142
24	autoimmune disease	10.7	TNF MIR146A IL6 IL4 IL17A ICOSLG
25	thymus gland disease	10.7	MIR142 MIR126 MIR125A ICOSLG H2AC18 CD8A
26	adult t-cell leukemia/lymphoma	10.7	MIR155 MIR142 ICOSLG H2AC18 CD8A CD4
27	thymus cancer	10.7	MIR142 MIR126 MIR125A ICOSLG H2AC18 CD8A
28	intestinal benign neoplasm	10.7	TNF SERPINA3 MIR31 MIR21 MIR199A1 MIR17
29	ovary epithelial cancer	10.7	SERPINA3 MIR21 MIR199A1 MIR17 MIR142 MIR126
30	autoimmune vasculitis	10.7	TNF IL6 IL17A H2AC18 CD8A CD4
31	conjunctivitis	10.7	TNF IL6 IL4
32	covid-19	10.7	TNF IL6 IL4 CCR6
33	chronic conjunctivitis	10.7	TNF IL6 IL4 IL17A ICOSLG CD4
34	salivary gland disease	10.7	TNF SERPINA3 IL6 IL4 ICOSLG H2AC18
35	chromosomal disease	10.7	SERPINA3 MIR21 MIR199A1 MIR17 MIR155 MIR142
36	west nile encephalitis	10.7	TNF IL6 IL4 ICOSLG H2AC18 CD8A
37	autoimmune disease of urogenital tract	10.7	TNF IL17A ICOSLG H2AC18 CD8A CD4
38	chromosomal deletion syndrome	10.7	MIR21 MIR17 MIR142 ICOSLG H2AC18 CD4
39	muscular disease	10.6	TNF SERPINA3 MIR21 MIR199A1 MIR17 MIR142
40	bile duct adenocarcinoma	10.6	SERPINA3 MIR31 MIR21 MIR199A1 MIR17 MIR142
41	skin carcinoma	10.6	TNF MIR31 MIR21 MIR199A1 ICOSLG H2AC18
42	human papillomavirus infectious disease	10.6	MIR31 MIR21 MIR199A1 MIR142 MIR125A ICOSLG
43	autonomic nervous system neoplasm	10.6	MIR31 MIR21 MIR199A1 MIR17 MIR142 MIR126
44	malignant exocrine pancreas neoplasm	10.6	SERPINA3 MIR31 MIR21 MIR199A1 MIR17 MIR142
45	bone remodeling disease	10.6	TNF SERPINA3 MIR199A1 MIR17 MIR142 MIR126
46	peripheral nervous system neoplasm	10.6	SERPINA3 MIR31 MIR21 MIR199A1 MIR17 MIR142
47	heart valve disease	10.6	SERPINA3 MIR21 MIR199A1 MIR17 MIR146A MIR142
48	crescentic glomerulonephritis	10.6	TNF MIR155 IL17A ICOSLG CD8A CD4
49	acute proliferative glomerulonephritis	10.6	TNF MIR155 IL17A ICOSLG CD8A CD4
50	meningitis	10.6	TNF IL6 IL4 IL17A

Graphical network of the top 20 diseases related to Integumentary System Disease:

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Symptoms & Phenotypes for Integumentary System Disease

MGI Mouse Phenotypes related to Integumentary System Disease:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	immune system	MP:0005387	10	CCR6 CD4 CD8A ERCC6 ICOSLG IL17A
2	hematopoietic system	MP:0005397	9.83	CCR6 CD4 CD8A ERCC6 ICOSLG IL17A
3	no phenotypic analysis	MP:0003012	9.8	CD4 IL17A IL4 MIR126 MIR146A MIR199A1
4	integument	MP:0010771	9.36	CD4 CD8A ERCC6 IL17A IL4 IL6

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Drugs & Therapeutics for Integumentary System Disease

Search Clinical Trials, NIH Clinical Center for Integumentary System Disease

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Genetic Tests for Integumentary System Disease

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Anatomical Context for Integumentary System Disease

Organs/tissues related to Integumentary System Disease:

FMA: Integumentary System Comprising The Skin

MalaCards : Skin

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Publications for Integumentary System Disease

Articles related to Integumentary System Disease:

#	Title	Authors	PMID	Year
1	Hereditary childhood hearing loss and integumentary system disease. ⁶²	Konigsmark BW	5026034	1972

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Genes for Integumentary System Disease

Genes related to Integumentary System Disease (0 elite genes):

(show top 50) (show all 106)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	CCR6	C-C Motif Chemokine Receptor 6	Protein Coding	15.23	DISEASES inferred ¹⁴ ¹⁴
2	ICOSLG	Inducible T Cell Costimulator Ligand	Protein Coding	12.49	DISEASES inferred ¹⁴ ¹⁴
3	H2AC18	H2A Clustered Histone 18	Protein Coding	11.88	DISEASES inferred ¹⁴ ¹⁴
4	SERPINA3	Serpin Family A Member 3	Protein Coding	11.49	DISEASES inferred ¹⁴ ¹⁴
5	ERCC6	ERCC Excision Repair 6, Chromatin Remodeling Factor	Protein Coding	11.14	DISEASES inferred ¹⁴ ¹⁴
6	MIR21	MicroRNA 21	RNA Gene	10.88	DISEASES inferred ¹⁴ ¹⁴
7	MIR155	MicroRNA 155	RNA Gene	10.04	DISEASES inferred ¹⁴ ¹⁴
8	MIR146A	MicroRNA 146a	RNA Gene	9.98	DISEASES inferred ¹⁴ ¹⁴
9	MIR142	MicroRNA 142	RNA Gene	9.92	DISEASES inferred ¹⁴ ¹⁴
10	MIR31	MicroRNA 31	RNA Gene	9.63	DISEASES inferred ¹⁴ ¹⁴
11	TNF	Tumor Necrosis Factor	Protein Coding	9.59	DISEASES inferred ¹⁴
12	CD4	CD4 Molecule	Protein Coding	9.55	DISEASES inferred ¹⁴
13	IL17A	Interleukin 17A	Protein Coding	9.5	DISEASES inferred ¹⁴
14	MIR199A1	MicroRNA 199a-1	RNA Gene	9.45	DISEASES inferred ¹⁴ ¹⁴
15	MIR17	MicroRNA 17	RNA Gene	9.34	DISEASES inferred ¹⁴ ¹⁴
16	MIR126	MicroRNA 126	RNA Gene	9.32	DISEASES inferred ¹⁴ ¹⁴
17	CD8A	CD8a Molecule	Protein Coding	9.3	DISEASES inferred ¹⁴
18	IL6	Interleukin 6	Protein Coding	9.27	DISEASES inferred ¹⁴
19	IL4	Interleukin 4	Protein Coding	9.19	DISEASES inferred ¹⁴
20	MIR125A	MicroRNA 125a	RNA Gene	9.12	DISEASES inferred ¹⁴ ¹⁴
21	U2AF1	U2 Small Nuclear RNA Auxiliary Factor 1	Protein Coding	9.08	DISEASES inferred ¹⁴ ¹⁴
22	IL10	Interleukin 10	Protein Coding	9.02	DISEASES inferred ¹⁴
23	IL1B	Interleukin 1 Beta	Protein Coding	9.01	DISEASES inferred ¹⁴
24	FLG	Filaggrin	Protein Coding	9	DISEASES inferred ¹⁴
25	MIR140	MicroRNA 140	RNA Gene	9	DISEASES inferred ¹⁴ ¹⁴
26	CRP	C-Reactive Protein	Protein Coding	8.96	DISEASES inferred ¹⁴
27	PRODH	Proline Dehydrogenase 1	Protein Coding	8.94	DISEASES inferred ¹⁴ ¹⁴
28	MIR223	MicroRNA 223	RNA Gene	8.94	DISEASES inferred ¹⁴ ¹⁴
29	MIRLET7A1	MicroRNA Let-7a-1	RNA Gene	8.89	DISEASES inferred ¹⁴ ¹⁴
30	IL13	Interleukin 13	Protein Coding	8.87	DISEASES inferred ¹⁴
31	CXCL8	C-X-C Motif Chemokine Ligand 8	Protein Coding	8.82	DISEASES inferred ¹⁴
32	IL2	Interleukin 2	Protein Coding	8.82	DISEASES inferred ¹⁴
33	MIR34A	MicroRNA 34a	RNA Gene	8.79	DISEASES inferred ¹⁴ ¹⁴
34	EPRS1	Glutamyl-Prolyl-TRNA Synthetase 1	Protein Coding	8.76	DISEASES inferred ¹⁴ ¹⁴
35	MIR20A	MicroRNA 20a	RNA Gene	8.73	DISEASES inferred ¹⁴ ¹⁴
36	IL5	Interleukin 5	Protein Coding	8.72	DISEASES inferred ¹⁴
37	CTLA4	Cytotoxic T-Lymphocyte Associated Protein 4	Protein Coding	8.71	DISEASES inferred ¹⁴
38	DSG1	Desmoglein 1	Protein Coding	8.64	DISEASES inferred ¹⁴
39	ALB	Albumin	Protein Coding	8.6	DISEASES inferred ¹⁴
40	SERPING1	Serpin Family G Member 1	Protein Coding	8.59	DISEASES inferred ¹⁴
41	TP53	Tumor Protein P53	Protein Coding	8.56	DISEASES inferred ¹⁴
42	MIR30A	MicroRNA 30a	RNA Gene	8.5	DISEASES inferred ¹⁴ ¹⁴
43	COL17A1	Collagen Type XVII Alpha 1 Chain	Protein Coding	8.5	DISEASES inferred ¹⁴
44	MIR9-1	MicroRNA 9-1	RNA Gene	8.48	DISEASES inferred ¹⁴ ¹⁴
45	DSG3	Desmoglein 3	Protein Coding	8.47	DISEASES inferred ¹⁴
46	MIRLET7C	MicroRNA Let-7c	RNA Gene	8.44	DISEASES inferred ¹⁴ ¹⁴
47	FOXP3	Forkhead Box P3	Protein Coding	8.42	DISEASES inferred ¹⁴
48	MIR145	MicroRNA 145	RNA Gene	8.41	DISEASES inferred ¹⁴ ¹⁴
49	TSLP	Thymic Stromal Lymphopoietin	Protein Coding	8.41	DISEASES inferred ¹⁴
50	MIR24-1	MicroRNA 24-1	RNA Gene	8.39	DISEASES inferred ¹⁴ ¹⁴

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Variations for Integumentary System Disease

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Expression for Integumentary System Disease

Search GEO for disease gene expression data for Integumentary System Disease.

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Pathways for Integumentary System Disease

Pathways related to Integumentary System Disease according to GeneCards Suite gene sharing:

(show all 21)

#	Super pathways	Score	Top Affiliating Genes
1	T-cell activation SARS-CoV-2 ⁷⁴ Show member pathways T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection ⁷⁴	11.98	TNF IL4 IL17A CD8A CD4
2	Interleukin-4 and Interleukin-13 signaling ⁶⁶	11.86	TNF IL6 IL4 IL17A
3	Hematopoietic Stem Cells and Lineage-specific Markers ⁶⁵	11.83	TNF IL6 IL4 CD8A CD4
4	IL27-mediated signaling events ⁶¹ Show member pathways IL12 signaling pathway ⁶⁷ Th1 Differentiation ⁶⁵	11.81	TNF IL6 IL17A CD4
5	Th17 Differentiation ⁶⁵ Show member pathways IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types ⁶⁵	11.75	IL6 IL4 IL17A CD4
6	Cell differentiation - expanded index ⁷⁴ Show member pathways Cell differentiation - index ⁷⁴	11.67	MIR199A1 MIR17 MIR155
7	Network map of SARS-CoV-2 signaling pathway ⁷⁴ Show member pathways Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex ⁷⁴	11.65	IL6 CD8A CD4
8	Dendritic Cells Developmental Lineage Pathway ⁶⁵	11.65	TNF IL6 CD8A CD4
9	Extrafollicular B cell activation by SARS-CoV-2 ⁷⁴	11.61	ICOSLG IL4 IL6 TNF
10	Th17 cell differentiation pathway ⁷⁴	11.57	IL6 IL4 IL17A CD4
11	Lung fibrosis ⁷⁴	11.55	TNF IL6 IL4
12	Inflammatory bowel disease signaling ⁷⁴ Show member pathways Ulcerative colitis signaling ⁷⁴	11.51	TNF IL6 IL4
13	Interactions between immune cells and microRNAs in tumor microenvironment ⁷⁴	11.4	MIR21 MIR146A IL4
14	Innate Lymphoid Cells Differentiation ⁶⁵	11.34	TNF IL4 IL17A CD8A CD4 CCR6
15	Prostaglandin signaling ⁷⁴	11.16	TNF IL6 IL17A
16	Development and heterogeneity of the ILC family ⁷⁴	11.13	TNF IL6 IL4 IL17A
17	Cytokines and inflammatory response ⁷⁴	11.02	TNF IL6 IL4 CD4
18	Immune infiltration in pancreatic cancer ⁷⁴	10.89	TNF IL6 IL4 IL17A
19	miRNAs involvement in the immune response in sepsis ⁷⁴	10.89	TNF MIR21 MIR199A1 MIR155 MIR126 IL6
20	IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types ⁶⁵	10.68	IL6 IL4
21	Cells and molecules involved in local acute inflammatory response ⁷⁴ Show member pathways IL8-mediated signaling events ⁶¹	10.26	TNF IL6

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GO Terms for Integumentary System Disease

Cellular components related to Integumentary System Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	external side of plasma membrane	GO:0009897	10.03	TNF IL17A ICOSLG CD8A CD4 CCR6
2	extracellular space	GO:0005615	9.91	IL17A IL4 IL6 MIR125A MIR126 MIR142
3	RISC complex	GO:0016442	9.55	MIR31 MIR21 MIR199A1 MIR17 MIR155 MIR146A
4	extracellular vesicle	GO:1903561	9.46	MIR21 MIR17 MIR126 MIR125A

Biological processes related to Integumentary System Disease according to GeneCards Suite gene sharing:

(show all 26)

#	Name	GO ID	Score	Top Affiliating Genes
1	immune response	GO:0006955	10.31	TNF IL6 IL4 IL17A CD8A CD4
2	miRNA-mediated gene silencing	GO:0035195	10.2	MIR125A MIR126 MIR142 MIR146A MIR155 MIR17
3	positive regulation of gene expression	GO:0010628	10.17	TNF MIR21 MIR17 MIR146A MIR125A IL6
4	T cell activation	GO:0042110	10.11	IL4 ICOSLG CD8A CD4
5	cellular response to lipopolysaccharide	GO:0071222	10.02	IL6 MIR146A MIR17 MIR21 TNF
6	negative regulation of gene expression	GO:0010629	10.01	TNF MIR21 MIR199A1 MIR17 MIR155 MIR146A
7	positive regulation of protein kinase B signaling	GO:0051897	9.99	TNF MIR21 MIR199A1 MIR126
8	positive regulation of mononuclear cell migration	GO:0071677	9.92	TNF IL4
9	positive regulation of leukocyte adhesion to vascular endothelial cell	GO:1904996	9.89	TNF MIR21 IL6
10	negative regulation of endothelial cell proliferation	GO:0001937	9.88	TNF MIR21 MIR146A
11	positive regulation of vascular associated smooth muscle cell proliferation	GO:1904707	9.88	MIR146A MIR17 MIR21 TNF
12	positive regulation of neuroinflammatory response	GO:0150078	9.85	TNF MIR142 IL6
13	negative regulation of interleukin-1-mediated signaling pathway	GO:2000660	9.8	MIR21 IL6
14	negative regulation of bicellular tight junction assembly	GO:1903347	9.78	TNF MIR142
15	positive regulation of cell migration involved in sprouting angiogenesis	GO:0090050	9.74	MIR31 MIR146A MIR126
16	positive regulation of sprouting angiogenesis	GO:1903672	9.73	MIR31 MIR126 MIR125A
17	positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	GO:1903589	9.7	MIR21 MIR146A MIR126
18	negative regulation of inflammatory response	GO:0050728	9.7	MIR31 MIR199A1 MIR146A MIR142 MIR126 IL4
19	miRNA-mediated gene silencing by inhibition of translation	GO:0035278	9.65	MIR31 MIR21 MIR17 MIR146A MIR126
20	positive regulation of cardiac muscle hypertrophy in response to stress	GO:1903244	9.62	MIR199A1 MIR17
21	negative regulation of vascular associated smooth muscle cell apoptotic process	GO:1905460	9.61	MIR21 MIR17
22	positive regulation of metalloendopeptidase activity	GO:1904685	9.6	MIR21 MIR17
23	negative regulation of matrix metallopeptidase secretion	GO:1904465	9.58	MIR199A1 MIR146A
24	negative regulation of leukocyte adhesion to vascular endothelial cell	GO:1904995	9.54	MIR31 MIR146A MIR125A
25	negative regulation of vascular endothelial growth factor production	GO:1904046	9.26	MIR199A1 MIR17 MIR146A MIR125A
26	positive regulation of cytokine production involved in inflammatory response	GO:1900017	9.23	TNF MIR21 MIR17 IL6 IL17A

Molecular functions related to Integumentary System Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	mRNA 3'-UTR binding	GO:0003730	9.61	MIR31 MIR21 MIR199A1 MIR17 MIR155 MIR146A
2	mRNA base-pairing translational repressor activity	GO:1903231	9.28	MIR31 MIR21 MIR199A1 MIR17 MIR155 MIR146A

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Sources for Integumentary System Disease

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: INT379 MIFTS: 29	Integumentary System Disease Categories: Skin diseases	Data Licensing For inquiries, contact: [email protected]
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