MCID: INT276
MIFTS: 28

Interatrial Communication

Categories: Cardiovascular diseases, Fetal diseases, Rare diseases

Aliases & Classifications for Interatrial Communication

MalaCards integrated aliases for Interatrial Communication:

Name: Interatrial Communication 59
Interauricular Communication 59
Atrial Septal Defect 59
Asd 59

Characteristics:

Orphanet epidemiological data:

59
interatrial communication
Age of onset: Childhood;

Classifications:



External Ids:

Orphanet 59 ORPHA1478
ICD10 via Orphanet 34 Q21.1
MESH via Orphanet 45 D006344
UMLS via Orphanet 74 C0018817 C2609256
SNOMED-CT via HPO 69 253366007 405752007 70142008

Summaries for Interatrial Communication

MalaCards based summary : Interatrial Communication, also known as interauricular communication, is related to atrial heart septal defect and atrial septal defect 2. An important gene associated with Interatrial Communication is RPL5 (Ribosomal Protein L5), and among its related pathways/superpathways is BMP Pathway. Affiliated tissues include heart, and related phenotype is atrial septal defect.

Related Diseases for Interatrial Communication

Diseases related to Interatrial Communication via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 42)
# Related Disease Score Top Affiliating Genes
1 atrial heart septal defect 27.9 DMD NKX2-5 RPL5
2 atrial septal defect 2 12.7
3 atrial septal defect 3 12.7
4 atrial septal defect 7 with or without atrioventricular conduction defects 12.6
5 atrial septal defect 4 12.6
6 atrial septal defect 5 12.6
7 atrial septal defect 6 12.6
8 atrial septal defect 8 12.6
9 atrial septal defect 9 12.6
10 atrial septal defect 1 12.6
11 hydrops fetalis, nonimmune, and/or atrial septal defect 12.5
12 atrial septal defect sinus venosus 12.5
13 atrial septal defect coronary sinus 12.4
14 autism spectrum disorder 12.0
15 catel-manzke syndrome 11.1
16 restrictive dermopathy, lethal 11.1
17 kleefstra syndrome 11.1
18 right ventricle hypoplasia 11.1
19 hypoplastic left heart syndrome 10.0
20 hypoplastic left heart syndrome 1 10.0
21 pulmonary hypertension 9.7
22 hemangioma 9.7
23 cor triatriatum 9.7
24 down syndrome 9.7
25 double discordia 9.7
26 mitral atresia 9.7
27 tricuspid atresia 9.7
28 protein-losing enteropathy 9.7
29 transposition of the great arteries 9.7
30 patent ductus arteriosus 1 9.7
31 heart disease 9.7
32 univentricular heart 9.7
33 patent foramen ovale 9.7
34 hypothyroidism 9.7
35 tricuspid valve stenosis 9.7
36 cavernous hemangioma 9.7
37 pulmonary valve stenosis 9.7
38 situs inversus 9.7
39 dextrocardia 9.7
40 hypertrophic pyloric stenosis 9.3 DMD NKX2-5
41 pyloric stenosis 9.2 DMD NKX2-5
42 left ventricular noncompaction 9.0 DMD NKX2-5

Graphical network of the top 20 diseases related to Interatrial Communication:



Diseases related to Interatrial Communication

Symptoms & Phenotypes for Interatrial Communication

Human phenotypes related to Interatrial Communication:

59 32
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 atrial septal defect 59 32 hallmark (90%) Very frequent (99-80%) HP:0001631

Drugs & Therapeutics for Interatrial Communication

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Combined Use of Radiofrequency-ablation and Balloon-septostomy in the Creation of a Stable Inter-atrial Communication Not yet recruiting NCT03554330 Not Applicable
2 Non-Invasive Shunt Quantification in Interatrial Communication Not yet recruiting NCT03437148 Not Applicable

Search NIH Clinical Center for Interatrial Communication

Genetic Tests for Interatrial Communication

Anatomical Context for Interatrial Communication

MalaCards organs/tissues related to Interatrial Communication:

41
Heart

Publications for Interatrial Communication

Articles related to Interatrial Communication:

(show all 30)
# Title Authors Year
1
Right heart dilatation in a fetus with an abnormal foramen ovale valve: an indicator of interatrial communication restriction. ( 29730689 )
2018
2
Relationship between interatrial communication, ductus arteriosus, and pulmonary flow patterns in fetuses with transposition of the great arteries: prediction of neonatal desaturation. ( 28376948 )
2017
3
Impact of Interatrial Communication on Left Ventricle Performance in Patients with Significant Post-tricuspid Shunt. ( 26706468 )
2016
4
'End-stage' heart failure therapy: potential lessons from congenital heart disease: from pulmonary artery banding and interatrial communication to parallel circulation. ( 28011759 )
2016
5
Right atrial cavernous hemangioma with a diffuse hemangiomatosis and interatrial communication. ( 24548216 )
2015
6
Hemodynamic patterns of residual interatrial communication after transcatheter MitraClip repair. ( 24699012 )
2014
7
Natural history of newborn with borderline small left heart without interatrial communication. ( 24403365 )
2014
8
Stent implantation into the interatrial septum in patients with univentricular heart and a secondary restriction of interatrial communication. ( 22090221 )
2011
9
Cardiac intervention using high-intensity focused ultrasound: creation of interatrial communication in beating heart of an anesthetized rabbit. ( 20842654 )
2010
10
Application of Cardio-O-Fix occluders for transcatheter closure of patent ductus arteriosus and interatrial communications: Preliminary experience. ( 21154264 )
2010
11
Interatrial communication with unusual caval venous anomalies. ( 23804896 )
2010
12
Ostium Secundum-type interatrial communication: few clinical symptoms and great hemodynamic repercussion. ( 19229436 )
2008
13
Case 9/2007: interatrial communication and hypothyroidism in patient with Down syndrome. ( 18488125 )
2007
14
Case 8/2007: partial anomalous pulmonary venous connection into the right atrium with absence of interatrial communication. ( 18488124 )
2007
15
Implantation of stents to ensure an adequate interatrial communication in patients with hypoplastic left heart syndrome. ( 17612414 )
2007
16
Complete repair of conotruncal defects with an interatrial communication: oxygenation, hemodynamic status, and early outcome. ( 16996921 )
2006
17
Initial experience with intracardiac echocardiography guidance in transcatheter closure of interatrial communication (atrial septal defect, patent foramen ovale, fenestrated Fontan) in Saudi Arabia. ( 16861863 )
2006
18
Characteristics of the interatrial communication in patients undergoing transcatheter device closure of atrial septal defects for cryptogenic stroke. ( 16343163 )
2005
19
Scoring system to determine need for balloon atrial septostomy for restrictive interatrial communication in infants with hypoplastic left heart syndrome. ( 12909468 )
2003
20
The vestibular defect: an interatrial communication due to a deficiency in the atrial septal component derived from the vestibular spine. ( 12887076 )
2003
21
Fenestrated Amplatzer device for percutaneous creation of interatrial communication in patients after Fontan operation. ( 12929109 )
2003
22
Restrictive interatrial communication in hypoplastic left heart syndrome after modified Fontan repair. ( 14667654 )
2003
23
Nonobstructive ASD creation to qualify patients for the Fontan operation: effects on pulmonary hypertension due to restrictive left atrioventricular valve and interatrial communication. ( 12124968 )
2002
24
Interatrial communication through the mouth of the coronary sinus. ( 12206560 )
2002
25
Restrictive interatrial communication with protein-losing enteropathy and coagulopathy in hypoplastic left heart syndrome after Norwood palliation. ( 11922519 )
2002
26
Cor triatriatum associated with total anomalous pulmonary venous drainage in the setting of mitral atresia and a restrictive interatrial communication. ( 1614919 )
1992
27
Anomalous systemic venous to left atrial connection in tricuspid atresia with severely restrictive interatrial communication. ( 1946016 )
1991
28
A rare case of an adult with mitral, pulmonary and tricuspid valve stenosis with an interatrial communication and acquired cyanosis. ( 6500622 )
1984
29
Congenital pulmonary valve stenosis with intact ventricular septum and interatrial communication. ( 4649870 )
1972
30
Congenital corrected transposition of the great vessels with situs inversus and dextrocardia. Report of surgical repair of associated defects in a patient with pulmonary stenosis, interatrial communication and persistent "left" superior vena cava. ( 13733694 )
1961

Variations for Interatrial Communication

ClinVar genetic disease variations for Interatrial Communication:

6
(show top 50) (show all 333)
# Gene Variation Type Significance SNP ID Assembly Location
1 ABCC8 NM_000352.4(ABCC8): c.3517G> A (p.Val1173Met) single nucleotide variant Likely pathogenic rs141322087 GRCh37 Chromosome 11, 17426099: 17426099
2 ABCC8 NM_000352.4(ABCC8): c.3517G> A (p.Val1173Met) single nucleotide variant Likely pathogenic rs141322087 GRCh38 Chromosome 11, 17404552: 17404552
3 NKX2-5 NM_004387.3(NKX2-5): c.400_402delCGGinsAT (p.Arg134Metfs) indel Likely pathogenic rs397516908 GRCh37 Chromosome 5, 172660145: 172660147
4 NKX2-5 NM_004387.3(NKX2-5): c.400_402delCGGinsAT (p.Arg134Metfs) indel Likely pathogenic rs397516908 GRCh38 Chromosome 5, 173233142: 173233144
5 MYH6 NM_002471.3(MYH6): c.4960-9G> A single nucleotide variant Conflicting interpretations of pathogenicity rs557113705 GRCh37 Chromosome 14, 23855349: 23855349
6 MYH6 NM_002471.3(MYH6): c.4960-9G> A single nucleotide variant Conflicting interpretations of pathogenicity rs557113705 GRCh38 Chromosome 14, 23386140: 23386140
7 MYH6 NM_002471.3(MYH6): c.4293G> A (p.Met1431Ile) single nucleotide variant Conflicting interpretations of pathogenicity rs201016285 GRCh37 Chromosome 14, 23857430: 23857430
8 MYH6 NM_002471.3(MYH6): c.4293G> A (p.Met1431Ile) single nucleotide variant Conflicting interpretations of pathogenicity rs201016285 GRCh38 Chromosome 14, 23388221: 23388221
9 MYH6 NM_002471.3(MYH6): c.981C> T (p.Ser327=) single nucleotide variant Conflicting interpretations of pathogenicity rs148407931 GRCh37 Chromosome 14, 23871927: 23871927
10 MYH6 NM_002471.3(MYH6): c.981C> T (p.Ser327=) single nucleotide variant Conflicting interpretations of pathogenicity rs148407931 GRCh38 Chromosome 14, 23402718: 23402718
11 MYH6 NM_002471.3(MYH6): c.161G> A (p.Arg54Gln) single nucleotide variant Uncertain significance rs727503239 GRCh37 Chromosome 14, 23876272: 23876272
12 MYH6 NM_002471.3(MYH6): c.161G> A (p.Arg54Gln) single nucleotide variant Uncertain significance rs727503239 GRCh38 Chromosome 14, 23407063: 23407063
13 MYH6 NM_002471.3(MYH6): c.-5C> A single nucleotide variant Conflicting interpretations of pathogenicity rs183611755 GRCh37 Chromosome 14, 23876437: 23876437
14 MYH6 NM_002471.3(MYH6): c.-5C> A single nucleotide variant Conflicting interpretations of pathogenicity rs183611755 GRCh38 Chromosome 14, 23407228: 23407228
15 MYH6 NM_002471.3(MYH6): c.3979-8dupC duplication Conflicting interpretations of pathogenicity rs730880363 GRCh37 Chromosome 14, 23858272: 23858272
16 MYH6 NM_002471.3(MYH6): c.3979-8dupC duplication Conflicting interpretations of pathogenicity rs730880363 GRCh38 Chromosome 14, 23389063: 23389063
17 MYH6 NM_002471.3(MYH6): c.2430-14C> T single nucleotide variant Conflicting interpretations of pathogenicity rs190342289 GRCh37 Chromosome 14, 23863546: 23863546
18 MYH6 NM_002471.3(MYH6): c.2430-14C> T single nucleotide variant Conflicting interpretations of pathogenicity rs190342289 GRCh38 Chromosome 14, 23394337: 23394337
19 MYH6 NM_002471.3(MYH6): c.2097C> T (p.Gly699=) single nucleotide variant Conflicting interpretations of pathogenicity rs149734381 GRCh37 Chromosome 14, 23866243: 23866243
20 MYH6 NM_002471.3(MYH6): c.2097C> T (p.Gly699=) single nucleotide variant Conflicting interpretations of pathogenicity rs149734381 GRCh38 Chromosome 14, 23397034: 23397034
21 MYH6 NM_002471.3(MYH6): c.1410C> T (p.Asp470=) single nucleotide variant Conflicting interpretations of pathogenicity rs139886074 GRCh37 Chromosome 14, 23869918: 23869918
22 MYH6 NM_002471.3(MYH6): c.1410C> T (p.Asp470=) single nucleotide variant Conflicting interpretations of pathogenicity rs139886074 GRCh38 Chromosome 14, 23400709: 23400709
23 MYH6 NM_002471.3(MYH6): c.1122G> A (p.Ala374=) single nucleotide variant Conflicting interpretations of pathogenicity rs148091079 GRCh37 Chromosome 14, 23871692: 23871692
24 MYH6 NM_002471.3(MYH6): c.1122G> A (p.Ala374=) single nucleotide variant Conflicting interpretations of pathogenicity rs148091079 GRCh38 Chromosome 14, 23402483: 23402483
25 MYH6 NM_002471.3(MYH6): c.831G> T (p.Gln277His) single nucleotide variant Conflicting interpretations of pathogenicity rs140660481 GRCh37 Chromosome 14, 23872624: 23872624
26 MYH6 NM_002471.3(MYH6): c.831G> T (p.Gln277His) single nucleotide variant Conflicting interpretations of pathogenicity rs140660481 GRCh38 Chromosome 14, 23403415: 23403415
27 MYH6 NM_002471.3(MYH6): c.86G> A (p.Arg29Gln) single nucleotide variant Conflicting interpretations of pathogenicity rs150574114 GRCh37 Chromosome 14, 23876347: 23876347
28 MYH6 NM_002471.3(MYH6): c.86G> A (p.Arg29Gln) single nucleotide variant Conflicting interpretations of pathogenicity rs150574114 GRCh38 Chromosome 14, 23407138: 23407138
29 MYH6 NM_002471.3(MYH6): c.36G> A (p.Ala12=) single nucleotide variant Conflicting interpretations of pathogenicity rs141014719 GRCh37 Chromosome 14, 23876397: 23876397
30 MYH6 NM_002471.3(MYH6): c.36G> A (p.Ala12=) single nucleotide variant Conflicting interpretations of pathogenicity rs141014719 GRCh38 Chromosome 14, 23407188: 23407188
31 SOS1 NM_005633.3(SOS1): c.1352C> A (p.Thr451Lys) single nucleotide variant Uncertain significance rs730880218 GRCh37 Chromosome 2, 39250217: 39250217
32 SOS1 NM_005633.3(SOS1): c.1352C> A (p.Thr451Lys) single nucleotide variant Uncertain significance rs730880218 GRCh38 Chromosome 2, 39023076: 39023076
33 MYH6 NM_002471.3(MYH6): c.4193G> A (p.Arg1398Gln) single nucleotide variant Uncertain significance rs150815925 GRCh38 Chromosome 14, 23388321: 23388321
34 MYH6 NM_002471.3(MYH6): c.4193G> A (p.Arg1398Gln) single nucleotide variant Uncertain significance rs150815925 GRCh37 Chromosome 14, 23857530: 23857530
35 MYH6 NM_002471.3(MYH6): c.3979-8C> T single nucleotide variant Benign/Likely benign rs555976716 GRCh37 Chromosome 14, 23858272: 23858272
36 MYH6 NM_002471.3(MYH6): c.3979-8C> T single nucleotide variant Benign/Likely benign rs555976716 GRCh38 Chromosome 14, 23389063: 23389063
37 NKX2-5 NM_004387.3(NKX2-5): c.335-3C> G single nucleotide variant Likely pathogenic rs876657934 GRCh38 Chromosome 5, 173233212: 173233212
38 NKX2-5 NM_004387.3(NKX2-5): c.335-3C> G single nucleotide variant Likely pathogenic rs876657934 GRCh37 Chromosome 5, 172660215: 172660215
39 MYH6 NM_002471.3(MYH6): c.5112G> A (p.Ala1704=) single nucleotide variant Conflicting interpretations of pathogenicity rs150450178 GRCh37 Chromosome 14, 23855188: 23855188
40 MYH6 NM_002471.3(MYH6): c.5112G> A (p.Ala1704=) single nucleotide variant Conflicting interpretations of pathogenicity rs150450178 GRCh38 Chromosome 14, 23385979: 23385979
41 MYH6 NM_002471.3(MYH6): c.3428G> A (p.Arg1143Gln) single nucleotide variant Uncertain significance rs543585784 GRCh37 Chromosome 14, 23859570: 23859570
42 MYH6 NM_002471.3(MYH6): c.3428G> A (p.Arg1143Gln) single nucleotide variant Uncertain significance rs543585784 GRCh38 Chromosome 14, 23390361: 23390361
43 MYH6 NM_002471.3(MYH6): c.1131C> T (p.Asp377=) single nucleotide variant Conflicting interpretations of pathogenicity rs61742472 GRCh37 Chromosome 14, 23871683: 23871683
44 MYH6 NM_002471.3(MYH6): c.1131C> T (p.Asp377=) single nucleotide variant Conflicting interpretations of pathogenicity rs61742472 GRCh38 Chromosome 14, 23402474: 23402474
45 MYH6 NM_002471.3(MYH6): c.1244G> C (p.Gly415Ala) single nucleotide variant Uncertain significance rs759520932 GRCh38 Chromosome 14, 23400875: 23400875
46 MYH6 NM_002471.3(MYH6): c.1244G> C (p.Gly415Ala) single nucleotide variant Uncertain significance rs759520932 GRCh37 Chromosome 14, 23870084: 23870084
47 MYH6 NM_002471.3(MYH6): c.5598A> G (p.Leu1866=) single nucleotide variant Benign/Likely benign rs17091278 GRCh37 Chromosome 14, 23852497: 23852497
48 MYH6 NM_002471.3(MYH6): c.5598A> G (p.Leu1866=) single nucleotide variant Benign/Likely benign rs17091278 GRCh38 Chromosome 14, 23383288: 23383288
49 46;XY;t(16;20)(q11.2;q13.2)dn Translocation Uncertain significance
50 46;XY;t(9;11)(q34;p11.2)dn Translocation Pathogenic

Expression for Interatrial Communication

Search GEO for disease gene expression data for Interatrial Communication.

Pathways for Interatrial Communication

Pathways related to Interatrial Communication according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.08 DMD NKX2-5

GO Terms for Interatrial Communication

Cellular components related to Interatrial Communication according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ribosome GO:0005840 8.96 DMD RPL5
2 protein-containing complex GO:0032991 8.8 DMD NKX2-5 RPL5

Biological processes related to Interatrial Communication according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.16 NKX2-5 RPL5
2 positive regulation of neuron differentiation GO:0045666 8.96 DMD NKX2-5
3 cardiac muscle contraction GO:0060048 8.62 DMD NKX2-5

Sources for Interatrial Communication

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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