ASD
MCID: INT276
MIFTS: 33

Interatrial Communication (ASD)

Categories: Cardiovascular diseases, Fetal diseases, Rare diseases

Aliases & Classifications for Interatrial Communication

MalaCards integrated aliases for Interatrial Communication:

Name: Interatrial Communication 59
Interauricular Communication 59
Atrial Septal Defect 59
Asd 59

Characteristics:

Orphanet epidemiological data:

59
interatrial communication
Age of onset: Childhood;

Classifications:



External Ids:

Orphanet 59 ORPHA1478
ICD10 via Orphanet 34 Q21.1
MESH via Orphanet 45 D006344
UMLS via Orphanet 74 C0018817 C2609256
SNOMED-CT via HPO 69 253366007 405752007 70142008

Summaries for Interatrial Communication

MalaCards based summary : Interatrial Communication, also known as interauricular communication, is related to left ventricular noncompaction and atrial heart septal defect. An important gene associated with Interatrial Communication is DMD (Dystrophin), and among its related pathways/superpathways is DREAM Repression and Dynorphin Expression. Affiliated tissues include heart, testes and lung, and related phenotype is atrial septal defect.

Related Diseases for Interatrial Communication

Diseases related to Interatrial Communication via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 361)
# Related Disease Score Top Affiliating Genes
1 left ventricular noncompaction 29.3 DMD NKX2-5
2 atrial heart septal defect 29.1 DMD NKX2-5 RPL5
3 atrial septal defect 2 12.8
4 atrial septal defect 6 12.8
5 atrial septal defect 3 12.8
6 atrial septal defect 4 12.7
7 atrial septal defect 5 12.7
8 atrial septal defect 8 12.7
9 atrial septal defect 9 12.7
10 brachydactyly, type e, with atrial septal defect, type ii 12.3
11 pulmonic stenosis, atrial septal defect, and unique electrocardiographic abnormalities 12.3
12 atrial septal defect, secundum, with various cardiac and noncardiac defects 12.3
13 autism spectrum disorder 12.3
14 tarp syndrome 12.1
15 neutropenia, severe congenital, 4, autosomal recessive 11.8
16 lymphedema, cardiac septal defects, and characteristic facies 11.7
17 asperger syndrome 11.7
18 hypoplastic right heart syndrome 11.6
19 autism 11.6
20 anterior segment dysgenesis 11.6
21 atrial septal defect 1 11.6
22 eisenmenger syndrome 11.5
23 noonan syndrome 1 11.5
24 irons bhan syndrome 11.4
25 shashi-pena syndrome 11.4
26 cardiofaciocutaneous syndrome 1 11.3
27 t-cell immunodeficiency, recurrent infections, and autoimmunity with or without cardiac malformations 11.3
28 restrictive dermopathy, lethal 11.2
29 kleefstra syndrome 11.2
30 right ventricle hypoplasia 11.2
31 atrial septal defect 7 with or without atrioventricular conduction defects 11.2
32 atrial septal defect ostium primum 11.2
33 catel-manzke syndrome 11.2
34 hypertelorism, teebi type 11.2
35 pagod syndrome 11.2
36 mcdonough syndrome 11.2
37 heterotaxy, visceral, 5, autosomal 11.2
38 white forelock with malformations 11.2
39 microphthalmia, syndromic 2 11.2
40 heterotaxy, visceral, 1, x-linked 11.2
41 cardiomyopathy, infantile histiocytoid 11.2
42 atrioventricular septal defect 3 11.2
43 axenfeld-rieger syndrome, type 3 11.2
44 atrioventricular septal defect 2 11.2
45 hirschsprung disease, cardiac defects, and autonomic dysfunction 11.2
46 ventricular septal defect 1 11.2
47 ventricular septal defect 3 11.2
48 cardiofaciocutaneous syndrome 2 11.2
49 cardiofaciocutaneous syndrome 3 11.2
50 cardiofaciocutaneous syndrome 4 11.2

Graphical network of the top 20 diseases related to Interatrial Communication:



Diseases related to Interatrial Communication

Symptoms & Phenotypes for Interatrial Communication

Human phenotypes related to Interatrial Communication:

59 32
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 atrial septal defect 59 32 hallmark (90%) Very frequent (99-80%) HP:0001631

Drugs & Therapeutics for Interatrial Communication

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Combined Use of Radiofrequency-ablation and Balloon-septostomy in the Creation of a Stable Inter-atrial Communication Recruiting NCT03554330 Not Applicable
2 Non-Invasive Shunt Quantification in Interatrial Communication Not yet recruiting NCT03437148 Not Applicable

Search NIH Clinical Center for Interatrial Communication

Genetic Tests for Interatrial Communication

Anatomical Context for Interatrial Communication

MalaCards organs/tissues related to Interatrial Communication:

41
Heart, Testes, Lung, Spinal Cord, T Cells

Publications for Interatrial Communication

Articles related to Interatrial Communication:

(show top 50) (show all 64)
# Title Authors Year
1
Right heart dilatation in a fetus with an abnormal foramen ovale valve: an indicator of interatrial communication restriction. ( 29730689 )
2018
2
Stable Interatrial Communication Combining Balloon Atrial Septostomy and Radiofrequency Catheter Ablation. ( 30286932 )
2018
3
Relationship between interatrial communication, ductus arteriosus, and pulmonary flow patterns in fetuses with transposition of the great arteries: prediction of neonatal desaturation. ( 28376948 )
2017
4
Impact of Interatrial Communication on Left Ventricle Performance in Patients with Significant Post-tricuspid Shunt. ( 26706468 )
2016
5
'End-stage' heart failure therapy: potential lessons from congenital heart disease: from pulmonary artery banding and interatrial communication to parallel circulation. ( 28011759 )
2016
6
Right atrial cavernous hemangioma with a diffuse hemangiomatosis and interatrial communication. ( 24548216 )
2015
7
Hemodynamic patterns of residual interatrial communication after transcatheter MitraClip repair. ( 24699012 )
2014
8
Natural history of newborn with borderline small left heart without interatrial communication. ( 24403365 )
2014
9
Stent implantation into the interatrial septum in patients with univentricular heart and a secondary restriction of interatrial communication. ( 22090221 )
2011
10
Cardiac intervention using high-intensity focused ultrasound: creation of interatrial communication in beating heart of an anesthetized rabbit. ( 20842654 )
2010
11
Interatrial communication with unusual caval venous anomalies. ( 23804896 )
2010
12
Ostium Secundum-type interatrial communication: few clinical symptoms and great hemodynamic repercussion. ( 19229436 )
2008
13
Case 9/2007: interatrial communication and hypothyroidism in patient with Down syndrome. ( 18488125 )
2007
14
Case 8/2007: partial anomalous pulmonary venous connection into the right atrium with absence of interatrial communication. ( 18488124 )
2007
15
Implantation of stents to ensure an adequate interatrial communication in patients with hypoplastic left heart syndrome. ( 17612414 )
2007
16
Complete repair of conotruncal defects with an interatrial communication: oxygenation, hemodynamic status, and early outcome. ( 16996921 )
2006
17
Initial experience with intracardiac echocardiography guidance in transcatheter closure of interatrial communication (atrial septal defect, patent foramen ovale, fenestrated Fontan) in Saudi Arabia. ( 16861863 )
2006
18
Characteristics of the interatrial communication in patients undergoing transcatheter device closure of atrial septal defects for cryptogenic stroke. ( 16343163 )
2005
19
Scoring system to determine need for balloon atrial septostomy for restrictive interatrial communication in infants with hypoplastic left heart syndrome. ( 12909468 )
2003
20
The vestibular defect: an interatrial communication due to a deficiency in the atrial septal component derived from the vestibular spine. ( 12887076 )
2003
21
Fenestrated Amplatzer device for percutaneous creation of interatrial communication in patients after Fontan operation. ( 12929109 )
2003
22
Restrictive interatrial communication in hypoplastic left heart syndrome after modified Fontan repair. ( 14667654 )
2003
23
Nonobstructive ASD creation to qualify patients for the Fontan operation: effects on pulmonary hypertension due to restrictive left atrioventricular valve and interatrial communication. ( 12124968 )
2002
24
Interatrial communication through the mouth of the coronary sinus. ( 12206560 )
2002
25
Restrictive interatrial communication with protein-losing enteropathy and coagulopathy in hypoplastic left heart syndrome after Norwood palliation. ( 11922519 )
2002
26
Fetal pulmonary venous flow pattern is determined by left atrial pressure: report of two cases of left heart hypoplasia, one with patent and the other with closed interatrial communication. ( 11952970 )
2002
27
Restrictive interatrial communication after reconstructive surgery for hypoplastic left heart syndrome. ( 11741576 )
2001
28
Hemodynamic evaluation for closing interatrial communication after fenestrated Fontan operation. ( 11385391 )
2001
29
Dilatation of a restrictive interatrial communication using a balloon angioplasty catheter. ( 11196752 )
2000
30
Spontaneous Obstruction of Interatrial Communication in Infants with Atrioventricular Valve Atresia or Stenosis in the Neonatal Period: Serial Echocardiographic-Doppler Study. ( 11175064 )
1998
31
Cavoatriopulmonary tunnel with valvular interatrial communication. ( 9690507 )
1997
32
Palliation by balloon atrial septostomy in total anomalous pulmonary venous connection with restrictive interatrial communication. ( 8631577 )
1996
33
Doppler echocardiographic analysis of flow in the ductus arteriosus of infants with hypoplastic left heart syndrome: relationship of flow patterns to systemic oxygenation and size of interatrial communication. ( 8849612 )
1996
34
Creation of a one-way interatrial communication in the treatment of critical pulmonary stenosis with intact ventricular septum: a case report. ( 8969384 )
1996
35
A new experimental model and formula for flow determination and possible application in sizing of interatrial communication. ( 7593139 )
1995
36
Cardiac catheterization and test occlusion of the interatrial communication after the fenestrated Fontan operation. ( 7759728 )
1995
37
Blade and balloon atrial septostomy for creation of an adequate interatrial communication. ( 7875704 )
1994
38
Cor triatriatum associated with total anomalous pulmonary venous drainage in the setting of mitral atresia and a restrictive interatrial communication. ( 1614919 )
1992
39
Quantification of flow through an interatrial communication. Application to the partial Fontan procedure. ( 1453736 )
1992
40
Anomalous systemic venous to left atrial connection in tricuspid atresia with severely restrictive interatrial communication. ( 1946016 )
1991
41
Partial Fontan: advantages of an adjustable interatrial communication. ( 1953128 )
1991
42
Nonocclusive intestinal ischemia and necrosis after correction of interatrial communication with cardiopulmonary bypass. A rare and catastrophic complication. ( 2600112 )
1989
43
Sinus venosus interatrial communication and sinus node problems. ( 3812307 )
1987
44
Sinus venosus interatrial communication and sinus node problems. ( 3825924 )
1987
45
Restrictive interatrial communication in total anomalous pulmonary venous connection. ( 3706165 )
1986
46
Creation and maintenance of an adequate interatrial communication in left atrioventricular valve atresia or stenosis. ( 3751932 )
1986
47
Cyanosis, interatrial communication, and normal pulmonary vascular resistance in adults. ( 3776873 )
1986
48
Blood flow pattern of the interatrial communication in patients with complete transposition of the great arteries: a pulsed Doppler echocardiographic study. ( 3940674 )
1986
49
Unusual interatrial communication after the Fontan procedure. ( 4046629 )
1985
50
A rare case of an adult with mitral, pulmonary and tricuspid valve stenosis with an interatrial communication and acquired cyanosis. ( 6500622 )
1984

Variations for Interatrial Communication

ClinVar genetic disease variations for Interatrial Communication:

6 (show top 50) (show all 424)
# Gene Variation Type Significance SNP ID Assembly Location
1 ABCC8 NM_000352.4(ABCC8): c.3517G> A (p.Val1173Met) single nucleotide variant Likely pathogenic rs141322087 GRCh37 Chromosome 11, 17426099: 17426099
2 ABCC8 NM_000352.4(ABCC8): c.3517G> A (p.Val1173Met) single nucleotide variant Likely pathogenic rs141322087 GRCh38 Chromosome 11, 17404552: 17404552
3 MYH6 NM_002471.3(MYH6): c.1753G> A (p.Gly585Ser) single nucleotide variant Uncertain significance rs150415679 GRCh37 Chromosome 14, 23868075: 23868075
4 MYH6 NM_002471.3(MYH6): c.1753G> A (p.Gly585Ser) single nucleotide variant Uncertain significance rs150415679 GRCh38 Chromosome 14, 23398866: 23398866
5 MYH6 NM_002471.3(MYH6): c.3979-8delC deletion Conflicting interpretations of pathogenicity rs193922652 GRCh37 Chromosome 14, 23858272: 23858272
6 MYH6 NM_002471.3(MYH6): c.3979-8delC deletion Conflicting interpretations of pathogenicity rs193922652 GRCh38 Chromosome 14, 23389063: 23389063
7 MYH6 NM_002471.3(MYH6): c.4651-12A> C single nucleotide variant Conflicting interpretations of pathogenicity rs193922653 GRCh37 Chromosome 14, 23855844: 23855844
8 MYH6 NM_002471.3(MYH6): c.4651-12A> C single nucleotide variant Conflicting interpretations of pathogenicity rs193922653 GRCh38 Chromosome 14, 23386635: 23386635
9 MYH6 NM_002471.3(MYH6): c.4959+13G> A single nucleotide variant Conflicting interpretations of pathogenicity rs28730765 GRCh37 Chromosome 14, 23855511: 23855511
10 MYH6 NM_002471.3(MYH6): c.4959+13G> A single nucleotide variant Conflicting interpretations of pathogenicity rs28730765 GRCh38 Chromosome 14, 23386302: 23386302
11 MYH6 NM_002471.3(MYH6): c.999C> T (p.Thr333=) single nucleotide variant Benign/Likely benign rs78107039 GRCh37 Chromosome 14, 23871909: 23871909
12 MYH6 NM_002471.3(MYH6): c.999C> T (p.Thr333=) single nucleotide variant Benign/Likely benign rs78107039 GRCh38 Chromosome 14, 23402700: 23402700
13 NKX2-5 NM_004387.3(NKX2-5): c.543G> A (p.Gln181=) single nucleotide variant Benign/Likely benign rs72554028 GRCh37 Chromosome 5, 172660004: 172660004
14 NKX2-5 NM_004387.3(NKX2-5): c.543G> A (p.Gln181=) single nucleotide variant Benign/Likely benign rs72554028 GRCh38 Chromosome 5, 173233001: 173233001
15 MYH6 NM_002471.3(MYH6): c.1071C> T (p.Ile357=) single nucleotide variant Conflicting interpretations of pathogenicity rs58131640 GRCh37 Chromosome 14, 23871743: 23871743
16 MYH6 NM_002471.3(MYH6): c.1071C> T (p.Ile357=) single nucleotide variant Conflicting interpretations of pathogenicity rs58131640 GRCh38 Chromosome 14, 23402534: 23402534
17 MYH6 NM_002471.3(MYH6): c.1335C> T (p.Asn445=) single nucleotide variant Benign/Likely benign rs61731179 GRCh37 Chromosome 14, 23869993: 23869993
18 MYH6 NM_002471.3(MYH6): c.1335C> T (p.Asn445=) single nucleotide variant Benign/Likely benign rs61731179 GRCh38 Chromosome 14, 23400784: 23400784
19 MYH6 NM_002471.3(MYH6): c.166G> A (p.Gly56Arg) single nucleotide variant Benign/Likely benign rs28711516 GRCh37 Chromosome 14, 23876267: 23876267
20 MYH6 NM_002471.3(MYH6): c.166G> A (p.Gly56Arg) single nucleotide variant Benign/Likely benign rs28711516 GRCh38 Chromosome 14, 23407058: 23407058
21 MYH6 NM_002471.3(MYH6): c.1809C> T (p.Asn603=) single nucleotide variant Conflicting interpretations of pathogenicity rs186134696 GRCh37 Chromosome 14, 23868019: 23868019
22 MYH6 NM_002471.3(MYH6): c.1809C> T (p.Asn603=) single nucleotide variant Conflicting interpretations of pathogenicity rs186134696 GRCh38 Chromosome 14, 23398810: 23398810
23 MYH6 NM_002471.3(MYH6): c.2151C> T (p.Tyr717=) single nucleotide variant Benign/Likely benign rs76202964 GRCh37 Chromosome 14, 23866189: 23866189
24 MYH6 NM_002471.3(MYH6): c.2151C> T (p.Tyr717=) single nucleotide variant Benign/Likely benign rs76202964 GRCh38 Chromosome 14, 23396980: 23396980
25 MYH6 NM_002471.3(MYH6): c.2806G> T (p.Ala936Ser) single nucleotide variant Benign/Likely benign rs141704264 GRCh37 Chromosome 14, 23862997: 23862997
26 MYH6 NM_002471.3(MYH6): c.2806G> T (p.Ala936Ser) single nucleotide variant Benign/Likely benign rs141704264 GRCh38 Chromosome 14, 23393788: 23393788
27 MYH6 NM_002471.3(MYH6): c.2928+5G> A single nucleotide variant Conflicting interpretations of pathogenicity rs28730772 GRCh37 Chromosome 14, 23862870: 23862870
28 MYH6 NM_002471.3(MYH6): c.2928+5G> A single nucleotide variant Conflicting interpretations of pathogenicity rs28730772 GRCh38 Chromosome 14, 23393661: 23393661
29 MYH6 NM_002471.3(MYH6): c.292G> A (p.Glu98Lys) single nucleotide variant Uncertain significance rs140596256 GRCh37 Chromosome 14, 23874889: 23874889
30 MYH6 NM_002471.3(MYH6): c.292G> A (p.Glu98Lys) single nucleotide variant Uncertain significance rs140596256 GRCh38 Chromosome 14, 23405680: 23405680
31 MYH6 NM_002471.3(MYH6): c.2946G> A (p.Glu982=) single nucleotide variant Benign/Likely benign rs145274612 GRCh37 Chromosome 14, 23862710: 23862710
32 MYH6 NM_002471.3(MYH6): c.2946G> A (p.Glu982=) single nucleotide variant Benign/Likely benign rs145274612 GRCh38 Chromosome 14, 23393501: 23393501
33 MYH6 NM_002471.3(MYH6): c.3199A> G (p.Ser1067Gly) single nucleotide variant Conflicting interpretations of pathogenicity rs145508517 GRCh37 Chromosome 14, 23862173: 23862173
34 MYH6 NM_002471.3(MYH6): c.3199A> G (p.Ser1067Gly) single nucleotide variant Conflicting interpretations of pathogenicity rs145508517 GRCh38 Chromosome 14, 23392964: 23392964
35 MYH6 NM_002471.3(MYH6): c.3302T> C (p.Val1101Ala) single nucleotide variant Benign/Likely benign rs365990 GRCh37 Chromosome 14, 23861811: 23861811
36 MYH6 NM_002471.3(MYH6): c.3302T> C (p.Val1101Ala) single nucleotide variant Benign/Likely benign rs365990 GRCh38 Chromosome 14, 23392602: 23392602
37 MYH6 NM_002471.3(MYH6): c.330G> A (p.Ala110=) single nucleotide variant Conflicting interpretations of pathogenicity rs77679218 GRCh37 Chromosome 14, 23874851: 23874851
38 MYH6 NM_002471.3(MYH6): c.330G> A (p.Ala110=) single nucleotide variant Conflicting interpretations of pathogenicity rs77679218 GRCh38 Chromosome 14, 23405642: 23405642
39 MYH6 NM_002471.3(MYH6): c.3388G> A (p.Ala1130Thr) single nucleotide variant Benign/Likely benign rs28730771 GRCh37 Chromosome 14, 23859610: 23859610
40 MYH6 NM_002471.3(MYH6): c.3388G> A (p.Ala1130Thr) single nucleotide variant Benign/Likely benign rs28730771 GRCh38 Chromosome 14, 23390401: 23390401
41 MYH6 NM_002471.3(MYH6): c.3408G> A (p.Lys1136=) single nucleotide variant Benign/Likely benign rs28730770 GRCh37 Chromosome 14, 23859590: 23859590
42 MYH6 NM_002471.3(MYH6): c.3408G> A (p.Lys1136=) single nucleotide variant Benign/Likely benign rs28730770 GRCh38 Chromosome 14, 23390381: 23390381
43 MYH6 NM_002471.3(MYH6): c.3480C> T (p.Ser1160=) single nucleotide variant Benign/Likely benign rs373345984 GRCh37 Chromosome 14, 23859518: 23859518
44 MYH6 NM_002471.3(MYH6): c.3480C> T (p.Ser1160=) single nucleotide variant Benign/Likely benign rs373345984 GRCh38 Chromosome 14, 23390309: 23390309
45 MYH6 NM_002471.3(MYH6): c.3609C> G (p.Ala1203=) single nucleotide variant Benign/Likely benign rs149369904 GRCh37 Chromosome 14, 23859389: 23859389
46 MYH6 NM_002471.3(MYH6): c.3609C> G (p.Ala1203=) single nucleotide variant Benign/Likely benign rs149369904 GRCh38 Chromosome 14, 23390180: 23390180
47 MYH6 NM_002471.3(MYH6): c.3627C> T (p.Ile1209=) single nucleotide variant Benign/Likely benign rs147871745 GRCh37 Chromosome 14, 23859371: 23859371
48 MYH6 NM_002471.3(MYH6): c.3627C> T (p.Ile1209=) single nucleotide variant Benign/Likely benign rs147871745 GRCh38 Chromosome 14, 23390162: 23390162
49 MYH6 NM_002471.3(MYH6): c.393G> A (p.Leu131=) single nucleotide variant Benign/Likely benign rs17277970 GRCh37 Chromosome 14, 23874541: 23874541
50 MYH6 NM_002471.3(MYH6): c.393G> A (p.Leu131=) single nucleotide variant Benign/Likely benign rs17277970 GRCh38 Chromosome 14, 23405332: 23405332

Expression for Interatrial Communication

Search GEO for disease gene expression data for Interatrial Communication.

Pathways for Interatrial Communication

Pathways related to Interatrial Communication according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.08 DMD NKX2-5

GO Terms for Interatrial Communication

Cellular components related to Interatrial Communication according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ribosome GO:0005840 8.96 DMD RPL5
2 protein-containing complex GO:0032991 8.8 DMD NKX2-5 RPL5

Biological processes related to Interatrial Communication according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.16 NKX2-5 RPL5
2 positive regulation of neuron differentiation GO:0045666 8.96 DMD NKX2-5
3 cardiac muscle contraction GO:0060048 8.62 DMD NKX2-5

Sources for Interatrial Communication

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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