MCID: INT038
MIFTS: 35

Interdigitating Dendritic Cell Sarcoma

Categories: Blood diseases, Cancer diseases

Aliases & Classifications for Interdigitating Dendritic Cell Sarcoma

MalaCards integrated aliases for Interdigitating Dendritic Cell Sarcoma:

Name: Interdigitating Dendritic Cell Sarcoma 12 15 17
Dendritic Cell Sarcoma, Interdigitating 44 70
Interdigitating Cell Sarcoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:7848
MeSH 44 D054739
NCIt 50 C9282
SNOMED-CT 67 128815007
ICD10 32 C96.4
UMLS 70 C1260326

Summaries for Interdigitating Dendritic Cell Sarcoma

Disease Ontology : 12 A histiocytic and dendritic cell cancer that effect dendritic cells.

MalaCards based summary : Interdigitating Dendritic Cell Sarcoma, also known as dendritic cell sarcoma, interdigitating, is related to reticulum cell sarcoma and rare tumor, and has symptoms including fatigue, fever and night sweats. An important gene associated with Interdigitating Dendritic Cell Sarcoma is POLQ (DNA Polymerase Theta), and among its related pathways/superpathways are Tight junction and Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. The drugs Pembrolizumab and Antineoplastic Agents, Immunological have been mentioned in the context of this disorder. Affiliated tissues include lymph node, skin and spleen.

Wikipedia : 73 Interdigitating dendritic cell sarcoma is a form of malignant histiocytosis affecting dendritic... more...

Related Diseases for Interdigitating Dendritic Cell Sarcoma

Diseases related to Interdigitating Dendritic Cell Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 107)
# Related Disease Score Top Affiliating Genes
1 reticulum cell sarcoma 32.2 CR2 CR1
2 rare tumor 31.4 FSCN1 CR2
3 histiocytosis 30.4 SERPINA3 CD1C CD1A
4 follicular dendritic cell sarcoma 30.3 CR2 CR1
5 langerhans cell histiocytosis 30.2 FSCN1 CD1C CD1A
6 dendritic cell tumor 30.0 FSCN1 CR2 CR1 CD1A
7 fibrosarcoma of bone 28.8 SERPINA3 CD1E CD1C CD1B CD1A
8 connective tissue benign neoplasm 28.8 SERPINA3 CD1E CD1C CD1B CD1A
9 histiocytic and dendritic cell cancer 28.7 SERPINA3 CR2 CR1 CD1E CD1C CD1B
10 sarcoma 11.1
11 spindle cell sarcoma 11.1
12 melanoma 10.6
13 anaplastic large cell lymphoma 10.4
14 lymphoma 10.4
15 malignant spindle cell melanoma 10.4
16 posttransplant acute limbic encephalitis 10.4
17 pancytopenia 10.3
18 b-cell lymphoma 10.3
19 chromosomal triplication 10.3
20 leukemia, chronic lymphocytic 10.1
21 human herpesvirus 8 10.1
22 mature t-cell and nk-cell lymphoma 10.1
23 diffuse large b-cell lymphoma 10.1
24 follicular lymphoma 10.1
25 paraneoplastic pemphigus 10.1
26 angioimmunoblastic t-cell lymphoma 10.1
27 respiratory failure 10.1
28 thrombocytopenia 10.1
29 leiomyosarcoma 10.1
30 retroperitoneal leiomyosarcoma 10.1
31 malignant peripheral nerve sheath tumor 10.1
32 cll/sll 10.1
33 ileus 10.1
34 pemphigus 10.1
35 acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) 10.1
36 soft tissue sarcoma 10.1
37 splenomegaly 10.1
38 histiocytic sarcoma 10.1
39 parapharyngeal meningioma 10.1 CR2 CR1
40 rosai-dorfman disease 10.1 FSCN1 CR2
41 granulomatous gastritis 10.1 CR2 CR1
42 t-cell/histiocyte rich large b cell lymphoma 10.1 CR2 CR1
43 skin tag 10.1 SERPINA3 FNIP1
44 alk+ histiocytosis 10.1 FSCN1 CD1A
45 multicentric reticulohistiocytosis 10.0 SERPINA3 CD1E
46 endobronchial leiomyoma 10.0 CR2 CR1
47 chronic wasting disease 10.0 SERPINA3 CR2
48 reticulosarcoma 9.9 SERPINA3 FSCN1
49 smooth muscle tumor 9.9 SERPINA3 CR2
50 predominantly cortical thymoma 9.9 CD1E CD1A

Graphical network of the top 20 diseases related to Interdigitating Dendritic Cell Sarcoma:



Diseases related to Interdigitating Dendritic Cell Sarcoma

Symptoms & Phenotypes for Interdigitating Dendritic Cell Sarcoma

UMLS symptoms related to Interdigitating Dendritic Cell Sarcoma:


fatigue; fever; night sweats

Drugs & Therapeutics for Interdigitating Dendritic Cell Sarcoma

Drugs for Interdigitating Dendritic Cell Sarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pembrolizumab Approved Phase 2 1374853-91-4
2 Antineoplastic Agents, Immunological Phase 2
3 Antibodies Phase 2
4 Immunoglobulins Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase 2 Study of Pembrolizumab in Patients With Histiocyte/Dendritic Cell Neoplasms and Biologically Selected Subtypes of Relapsed/Refractory Aggressive Lymphomas Recruiting NCT03316573 Phase 2 Pembrolizumab

Search NIH Clinical Center for Interdigitating Dendritic Cell Sarcoma

Cochrane evidence based reviews: dendritic cell sarcoma, interdigitating

Genetic Tests for Interdigitating Dendritic Cell Sarcoma

Anatomical Context for Interdigitating Dendritic Cell Sarcoma

MalaCards organs/tissues related to Interdigitating Dendritic Cell Sarcoma:

40
Lymph Node, Skin, Spleen, Tonsil, Bone Marrow, Small Intestine, Colon

Publications for Interdigitating Dendritic Cell Sarcoma

Articles related to Interdigitating Dendritic Cell Sarcoma:

(show top 50) (show all 107)
# Title Authors PMID Year
1
Histiocytosis and Neoplasms of Macrophage-Dendritic Cell Lineages: Multimodality Imaging with Emphasis on PET/CT. 61
33606566 2021
2
Retroperitoneal dendritic cell sarcoma: A case report. 61
33655917 2021
3
Descriptive Analysis of Histiocytic and Dendritic Cell Neoplasms: A Single-Institution Experience. 61
32882761 2020
4
Multifocal Interdigitating Dendritic Cell Sarcoma Demonstrated on FDG PET/CT Imaging. 61
32604117 2020
5
New insights inside the interdigitating dendritic cell sarcoma-pooled analysis and review of literature. 61
31741033 2019
6
[Chemotherapy bridged hematopoietic stem cell transplantation for the treatment of interdigitating dendritic cell sarcoma: a case report and literature review]. 61
31648482 2019
7
[Clinicopathological characteristics and differential diagnosis of interdigitating dendritic cell sarcoma]. 61
31216832 2019
8
Interdigitating dendritic cell sarcoma of the spleen with hepatic failure after chemotherapy: A case report. 61
31083204 2019
9
[Clinicopathological features of interdigitating dendritic cell sarcoma]. 61
30831653 2019
10
Genomic characterization of metastatic ultra-hypermutated interdigitating dendritic cell sarcoma through rapid research autopsy. 61
30719225 2019
11
A case of interdigitating dendritic cell sarcoma studied by whole-exome sequencing. 61
30099721 2018
12
Interdigitating dendritic cell sarcoma located in the groin: a case report and literature review. 61
30222020 2018
13
Clonally related diffuse large B-cell lymphoma and interdigitating dendritic cell sarcoma sharing MYC translocation. 61
30237263 2018
14
Neoplastic PD-L1 expression on interdigitating dendritic cell sarcoma: A supplementary study of a case report. 61
30094900 2018
15
Interdigitating dendritic cell sarcoma: Clinicopathologic study of 8 cases with review of the literature. 61
29660568 2018
16
Expression of enhancer of zeste homolog 2 (EZH2) protein in histiocytic and dendritic cell neoplasms with evidence for p-ERK1/2-related, but not MYC- or p-STAT3-related cell signaling. 61
29327713 2018
17
Primary lesions that may imitate metastatic tumors histologically: A selective review. 61
29174934 2018
18
Primary jejunal interdigitating dendritic cell sarcoma. 61
29414390 2018
19
Primary cutaneous interdigitating dendritic cell sarcoma is a morphologic and phenotypic simulator of poorly differentiated metastatic melanoma: A report of 2 cases and review of the literature. 61
28302385 2017
20
Interdigitating dendritic cell sarcoma: diagnostic pitfalls, treatment challenges and role of transdifferentation in pathogenesis. 61
28830690 2017
21
An unusual case of metachronous NK/T cell lymphoma and interdigitating dendritic cell sarcoma. 61
29043241 2017
22
A Rare Case of Interdigitating Dendritic Cell Sarcoma of the Rectum: Review of Histopathology and Management Strategy. 61
28784918 2017
23
Interdigitating dendritic cell sarcoma presenting in the sigmoid colon mesentery: A case report and literature review. 61
28422825 2017
24
Diffuse lesion and necrosis tied to poorer prognosis of interdigitating dendritic cell sarcoma: cases report and a pooled analysis. 61
28386111 2017
25
Interdigitating dendritic cell sarcoma successfully treated with ABVD therapy in which serum CEA levels correlated with disease activity. 61
28484155 2017
26
[Disseminated interdigitating dendritic cell sarcoma]. 61
28643685 2017
27
Oncogene Status of an Interdigitating Dendritic Cell Sarcoma: Recurrent Mutations in NF1, TP53, and ARID2 Shared With Melanoma. 61
27680605 2016
28
High frequency of clonal IG and T-cell receptor gene rearrangements in histiocytic and dendritic cell neoplasms. 61
27823979 2016
29
Spindle Cell Melanoma and Interdigitating Dendritic Cell Sarcoma: Do They Represent the Same Process? 61
27299798 2016
30
Primary Cutaneous Interdigitating Dendritic Cell Sarcoma: A Case Report and Review of the Literature. 61
27442049 2016
31
Head and Neck Extranodal Interdigitating Dendritic Cell Sarcoma: Case Report and Review of the Literature. 61
25893828 2016
32
Clinicopathological features of inflammatory pseudotumour-like follicular dendritic cell tumour of the abdomen. 61
26332157 2016
33
Intracranial Interdigitating Dendritic Cell Sarcoma: First Case Report. 61
26237342 2015
34
Impact of surgery, radiation and systemic therapy on the outcomes of patients with dendritic cell and histiocytic sarcomas. 61
26298731 2015
35
Primary Cutaneous Interdigitating Dendritic Cell Sarcoma: A Case Report and Review of the Literature. 61
25321088 2015
36
Spontaneous regression of interdigitating dendritic sarcoma in a patient with concurrent small lymphocytic lymphoma. 61
26071439 2015
37
Evidence of BRAF V600E in indeterminate cell tumor and interdigitating dendritic cell sarcoma. 61
25787243 2015
38
Challenges in the differential diagnosis of interdigitating dendritic cell sarcoma of intraparotid lymph node vs. metastatic malignant melanoma with unknown primary site. 61
25722315 2015
39
Interdigitating dendritic cell sarcoma. 61
25691604 2015
40
Braf mutation in interdigitating dendritic cell sarcoma: a case report and review of the literature. 61
26047060 2015
41
Complete Remission in Systemic Skin Interdigitating Dendritic Cell Sarcoma after ABVD Chemotherapy. 61
26106005 2015
42
Sustained remission after ABVD treatment for interdigitating dendritic cell sarcoma. 61
26199576 2015
43
Clinicopathologic characteristics and outcomes of histiocytic and dendritic cell neoplasms: the moffitt cancer center experience over the last twenty five years. 61
25405526 2014
44
Interdigitating dendritic cell sarcoma presenting in the skin: diagnosis and the role of surgical resection, chemotherapy and radiotherapy in management. 61
25568750 2014
45
Dendritic cell and histiocytic neoplasms: biology, diagnosis, and treatment. 61
25310210 2014
46
Interdigitating dendritic cell sarcoma presenting in the kidney combined with retroperitoneal leiomyosarcoma: A case report and literature review. 61
24396471 2014
47
The genetics of interdigitating dendritic cell sarcoma share some changes with Langerhans cell histiocytosis in select cases. 61
24321462 2014
48
[Interdigitating dendritic cell sarcoma/tumor: a clinicopathologic study]. 61
24742569 2014
49
A case of interdigitating dendritic cell sarcoma/histiocytic sarcoma--a diagnostic pitfall. 61
24427360 2014
50
Dendritic cell sarcoma: a pooled analysis including 462 cases with presentation of our case series. 61
23755890 2013

Variations for Interdigitating Dendritic Cell Sarcoma

Expression for Interdigitating Dendritic Cell Sarcoma

Search GEO for disease gene expression data for Interdigitating Dendritic Cell Sarcoma.

Pathways for Interdigitating Dendritic Cell Sarcoma

Pathways related to Interdigitating Dendritic Cell Sarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.68 CD1E CD1C CD1B CD1A
2 11.56 CD1C CD1B CD1A
3 11.27 CD1E CD1C CD1B CD1A
4 11.14 CR2 CR1
5 11.1 CR2 CR1 CD1E CD1C CD1B CD1A

GO Terms for Interdigitating Dendritic Cell Sarcoma

Cellular components related to Interdigitating Dendritic Cell Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endosome GO:0005768 9.46 CD1E CD1C CD1B CD1A
2 endosome membrane GO:0010008 9.43 CD1C CD1B CD1A
3 lysosome GO:0005764 9.26 FNIP1 CD1E CD1C CD1B
4 external side of plasma membrane GO:0009897 8.92 CD1E CD1C CD1B CD1A

Biological processes related to Interdigitating Dendritic Cell Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 adaptive immune response GO:0002250 9.73 CD1E CD1C CD1B CD1A
2 immune system process GO:0002376 9.73 CR2 CR1 CD1E CD1C CD1B CD1A
3 immune response GO:0006955 9.72 CR2 CD1E CD1C CD1B CD1A
4 regulation of immune response GO:0050776 9.63 CD1C CD1B CD1A
5 positive regulation of T cell mediated cytotoxicity GO:0001916 9.46 CD1E CD1C CD1B CD1A
6 complement activation, alternative pathway GO:0006957 9.4 CR2 CR1
7 complement receptor mediated signaling pathway GO:0002430 9.37 CR2 CR1
8 antigen processing and presentation, exogenous lipid antigen via MHC class Ib GO:0048007 9.26 CD1E CD1C CD1B CD1A
9 antigen processing and presentation, endogenous lipid antigen via MHC class Ib GO:0048006 8.92 CD1E CD1C CD1B CD1A

Molecular functions related to Interdigitating Dendritic Cell Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipopeptide binding GO:0071723 9.46 CD1E CD1C CD1B CD1A
2 exogenous lipid antigen binding GO:0030884 9.26 CD1E CD1C CD1B CD1A
3 endogenous lipid antigen binding GO:0030883 8.92 CD1E CD1C CD1B CD1A

Sources for Interdigitating Dendritic Cell Sarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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