MCID: INT064
MIFTS: 53

Intermediate Uveitis

Categories: Eye diseases, Immune diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Intermediate Uveitis

MalaCards integrated aliases for Intermediate Uveitis:

Name: Intermediate Uveitis 12 60 15 17
Uveitis, Intermediate 45 74
Peripheral Uveoretinitis 12
Uveitis Intermediate 56
Chronic Cyclitis 12
Iu 60

Characteristics:

Orphanet epidemiological data:

60
intermediate uveitis
Inheritance: Not applicable; Age of onset: Childhood; Age of death: normal life expectancy;

Classifications:

Orphanet: 60  
Rare eye diseases


External Ids:

Disease Ontology 12 DOID:12732
MeSH 45 D015867
NCIt 51 C35110
ICD10 via Orphanet 35 H30.2
UMLS via Orphanet 75 C0042166
Orphanet 60 ORPHA279914
UMLS 74 C0042166

Summaries for Intermediate Uveitis

MalaCards based summary : Intermediate Uveitis, also known as uveitis, intermediate, is related to uveitis and acute disseminated encephalomyelitis. An important gene associated with Intermediate Uveitis is IL2RA (Interleukin 2 Receptor Subunit Alpha), and among its related pathways/superpathways are ERK Signaling and PEDF Induced Signaling. The drugs Azathioprine and Infliximab have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and lung, and related phenotypes are hematopoietic system and cardiovascular system

Wikipedia : 77 Intermediate uveitis is a form of uveitis localized to the vitreous and peripheral retina. Primary... more...

Related Diseases for Intermediate Uveitis

Diseases in the Uveitis family:

Autoimmune Uveitis Posterior Uveitis
Intermediate Uveitis Infectious Anterior Uveitis
Anterior Uveitis Infectious Posterior Uveitis

Diseases related to Intermediate Uveitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 375)
# Related Disease Score Top Affiliating Genes
1 uveitis 30.4 CXCR3 HLA-B IL10 IL2RA TNF
2 acute disseminated encephalomyelitis 30.1 HLA-B IL10
3 panuveitis 30.1 HLA-B IL10 TNF
4 bacterial vaginosis 30.0 IL6 TNF
5 pulpitis 29.8 IL6 TNF
6 chikungunya 29.7 IL6 TNF
7 anterior uveitis 29.7 HLA-B IL2RA IL6
8 drug reaction with eosinophilia and systemic symptoms 29.6 HLA-B TNF
9 posterior uveitis 29.6 IL2 IL2RA IL6 TNF
10 rubella 29.3 HLA-B IL10 TNF
11 alopecia areata 29.2 IL2 IL2RA TNF
12 dermatitis, atopic 29.1 IL10 IL2 TNF
13 asthma 29.0 IL10 IL2RA IL6 TNF
14 multiple sclerosis 28.8 CXCR3 IL10 IL2 IL2RA IL6 TNF
15 autoimmune disease 28.4 IL10 IL2 IL2RA IL6 TNF
16 aphthous stomatitis 28.4 HLA-B IL10 IL2 IL6 TNF
17 congenital disorder of glycosylation, type iu 12.4
18 pars planitis 12.2
19 rickets 11.9
20 dpm2-cdg 11.5
21 factor xi deficiency 11.1
22 von willebrand's disease 11.1
23 epileptic encephalopathy, early infantile, 36 11.1
24 lymphoproliferative syndrome 2 10.4 CXCR3 IL2RA
25 endometrial hyperplasia 10.3
26 proliferative glomerulonephritis 10.3 CXCR3 IL6
27 human herpesvirus 8 10.3 HLA-B IL6
28 b-cell expansion with nfkb and t-cell anergy 10.2 IL2 IL2RA
29 pure red-cell aplasia 10.2 IL2 IL2RA
30 limited scleroderma 10.2 IL2 IL2RA
31 taeniasis 10.2 IL10 TGFBR3
32 vernal conjunctivitis 10.2 IL2 IL2RA
33 cervicitis 10.2 IL2 IL2RA
34 macular retinal edema 10.2
35 wells syndrome 10.2 IL2 IL2RA
36 brain injury 10.2 IL10 IL6
37 traumatic brain injury 10.2 IL10 IL6
38 multicentric castleman disease 10.2 IL10 IL6
39 castleman disease 10.2 IL10 IL6
40 funisitis 10.2 IL10 IL6
41 hand, foot and mouth disease 10.2 IL10 IL6
42 ovarian hyperstimulation syndrome 10.2
43 cystic echinococcosis 10.2 IL10 IL6
44 acute pyelonephritis 10.2 IL10 IL6
45 macular dystrophy, dominant cystoid 10.2
46 vasculitis 10.2
47 gaucher disease, type ii 10.1 IL10 IL2
48 adenomyosis 10.1
49 endometrial cancer 10.1
50 retinitis pigmentosa 44 10.1 IL10 IL2

Graphical network of the top 20 diseases related to Intermediate Uveitis:



Diseases related to Intermediate Uveitis

Symptoms & Phenotypes for Intermediate Uveitis

MGI Mouse Phenotypes related to Intermediate Uveitis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.95 CXCR3 IL10 IL2 IL2RA IL6 TGFBR3
2 cardiovascular system MP:0005385 9.93 CXCR3 IL10 IL2 IL6 TGFBR3 TNF
3 immune system MP:0005387 9.91 CXCR3 IL10 IL2 IL2RA IL6 TGFBR3
4 digestive/alimentary MP:0005381 9.83 IL10 IL2 IL2RA IL6 TNF
5 mortality/aging MP:0010768 9.8 CXCR3 IL10 IL2 IL2RA IL6 TGFBR3
6 liver/biliary system MP:0005370 9.72 IL10 IL2 IL6 TGFBR3 TNF
7 neoplasm MP:0002006 9.55 CXCR3 IL10 IL2 IL6 TNF
8 respiratory system MP:0005388 9.43 CXCR3 IL10 IL2 IL2RA IL6 TNF
9 vision/eye MP:0005391 9.02 IL10 IL2 IL2RA IL6 TNF

Drugs & Therapeutics for Intermediate Uveitis

Drugs for Intermediate Uveitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 98)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azathioprine Approved Phase 4 446-86-6 2265
2
Infliximab Approved Phase 4,Phase 1,Phase 2 170277-31-3
3
Mycophenolic acid Approved Phase 4,Phase 3 24280-93-1 446541
4
Methotrexate Approved Phase 4,Phase 3,Phase 1,Phase 2 1959-05-2, 59-05-2 126941
5
Chlorambucil Approved Phase 4 305-03-3 2708
6
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2 53-03-2 5865
7
Fluocinolone Acetonide Approved, Investigational, Vet_approved Phase 4,Phase 3,Not Applicable 67-73-2 6215
8
Tacrolimus Approved, Investigational Phase 4 104987-11-3 6473866 445643 439492
9
Cyclophosphamide Approved, Investigational Phase 4 50-18-0, 6055-19-2 2907
10
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 1177-87-3
11
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 50-02-2 5743
12 Antitubercular Agents Phase 4,Phase 3
13 Antimetabolites, Antineoplastic Phase 4,Phase 3,Phase 1,Phase 2
14 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1
15 Antirheumatic Agents Phase 4,Phase 3,Phase 1,Phase 2
16 Antimetabolites Phase 4,Phase 3,Phase 1,Phase 2
17 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Phase 1
18 Immunologic Factors Phase 4,Phase 3,Phase 1,Phase 2
19 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1
20 Cyclosporins Phase 4
21 Anti-Infective Agents Phase 4,Phase 3,Phase 1,Phase 2
22 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
23 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
24 Alkylating Agents Phase 4
25 glucocorticoids Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
26 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
27 Antineoplastic Agents, Alkylating Phase 4
28 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
29 Melanocyte-Stimulating Hormones Phase 4,Phase 2
30 beta-endorphin Phase 4,Phase 2
31 Adrenocorticotropic Hormone Phase 4,Phase 2
32 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2,Phase 1
33 Antiemetics Phase 4,Phase 3,Phase 2,Phase 1
34 Autonomic Agents Phase 4,Phase 3,Phase 2,Phase 1
35 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Phase 1
36 HIV Protease Inhibitors Phase 4,Phase 2,Phase 3
37 BB 1101 Phase 4,Phase 2,Phase 3,Phase 1
38 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
39
protease inhibitors Phase 4,Phase 2,Phase 3
40
Prednisolone phosphate Approved, Vet_approved Phase 3 302-25-0
41
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
42
Methylprednisolone hemisuccinate Approved Phase 3 2921-57-5
43
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
44
Adalimumab Approved Phase 3 331731-18-1 16219006
45
leucovorin Approved Phase 3,Phase 1,Phase 2 58-05-9 143 6006
46
Triamcinolone Approved, Vet_approved Phase 3,Phase 1,Phase 2 124-94-7 31307
47
Difluprednate Approved Phase 3 23674-86-4 443936
48
Fluprednisolone Approved Phase 3 53-34-9
49
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3,Phase 1,Phase 2 59-30-3 6037
50
Prednisolone hemisuccinate Experimental Phase 3 2920-86-7

Interventional clinical trials:

(show top 50) (show all 65)
# Name Status NCT ID Phase Drugs
1 Multicenter Uveitis Steroid Treatment (MUST) Trial Completed NCT00132691 Phase 4 fluocinolone acetonide intraocular implant;oral corticosteroid with immunosuppressive agents as needed
2 Study of H.P. ACTHAR Subcutaneous Gelatin (Gel)(Highly Purified Gel Injection) in Uveitis Patients Completed NCT02764697 Phase 4 H.P. ACTHAR SUBCUTANEOUS GEL INJECTION
3 Efficacy and Safety of H.P. Acthar® Gel in Subjects With Severe Noninfectious Intermediate Uveitis, Posterior Uveitis, or Panuveitis NIPPU Recruiting NCT03656692 Phase 4 Acthar
4 Study of the Effectiveness of Ozurdex for the Control of Uveitis Recruiting NCT02049476 Phase 4 Dexamethasone pellet
5 Myfortic for the Treatment of Non-infectious Intermediate Uveitis Completed NCT01092533 Phase 3 Myfortic;Decortin
6 Randomized, Controlled Trial to Test the Efficacy of Interferon Beta in the Treatment of Intermediate Uveitis Completed NCT00344253 Phase 3 Interferon beta;Methotrexate
7 Efficacy and Safety of Adalimumab in Subjects With Inactive Uveitis Completed NCT01124838 Phase 3 Adalimumab;Prednisone;Placebo
8 A Study of the Long-term Safety and Efficacy of Adalimumab in Subjects With Intermediate-, Posterior-, or Pan-uveitis Completed NCT01148225 Phase 3 adalimumab
9 A Study of the Safety and Efficacy of a New Treatment for Non-Infectious Intermediate or Posterior Uveitis Completed NCT00333814 Phase 2, Phase 3 Dexamethasone;dexamethasone;Sham injection
10 Efficacy and Safety of Adalimumab in Patients With Active Uveitis Completed NCT01138657 Phase 3 Prednisone;Placebo
11 A Controlled, Multi-center Study of the Utilization and Safety of the MK II Inserter and the Safety of the FAI Insert in Subjects With Non-infectious Uveitis Affecting the Posterior Segment of the Eye Completed NCT02748512 Phase 3 FAI insert
12 Phase III Study in Refractory Behcet's Disease Completed NCT00995709 Phase 3 AIN457;AIN457;Placebo
13 Suprachoroidal Injection of CLS-TA in Subjects Non-infectious Uveitis Completed NCT03097315 Phase 3
14 Suprachoroidal Injection of CLS-TA in Subjects With Macular Edema Associated With Non-infectious Uveitis Completed NCT02595398 Phase 3 4mg CLS-TA Suprachoriodal Injection;Sham Procedure
15 Difluprednate Pediatric Study for the Treatment of Inflammation Post-Cataract Surgery Completed NCT01124045 Phase 3 Difluprednate ophthalmic emulsion, 0.05%;Prednisolone acetate ophthalmic suspension, 1.0%
16 A Study of Tocilizumab in Patients With Active Polyarticular Juvenile Idiopathic Arthritis Completed NCT00988221 Phase 3 Tocilizumab;Placebo
17 A Study of LX211 in Clinically Quiescent Non-infectious Intermediate, Anterior and Intermediate, Posterior or Pan-Uveitis Completed NCT00404742 Phase 3 Placebo;LX211;LX211;LX211
18 A Study of LX211 in Active Sight Threatening, Non-infectious Intermediate-, Anterior and Intermediate-, Posterior-, or Pan-Uveitis Completed NCT00404612 Phase 3 Placebo;LX211;LX211;LX211
19 Safety and Efficacy of Difluprednate 0.05% for the Treatment of Anterior Uveitis Completed NCT01201798 Phase 3 Difluprednate 0.05% ophthalmic emulsion;Prednisolone acetate 1.0% ophthalmic suspension
20 Safety and Efficacy Study of a Fluocinolone Acetonide Intravitreal (FAI) Insert in Subjects With Chronic Non-infectious Posterior Uveitis Active, not recruiting NCT02746991 Phase 3 Sham Injection;FAI Insert
21 Safety and Efficacy of an Injectable Fluocinolone Acetonide Intravitreal Insert Active, not recruiting NCT01694186 Phase 3 FAI insert;Sham injection
22 38 Week Extension Study to CAIN457C2303 Terminated NCT01093846 Phase 3 AIN457;AIN457;Placebo AIN457
23 Safety and Efficacy of AIN457 in Patients With Active Non-infectious Uveitis Terminated NCT01095250 Phase 3 AIN457;AIN457;AIN457;Placebo
24 Safety and Efficacy of AIN457 in Patients With Quiescent Non-infectious Uveitis Terminated NCT01032915 Phase 3 Placebo
25 Long-term Safety of Gevokizumab in the Treatment of Patients With Chronic Non-infectious Uveitis (EYEGUARD-X) Terminated NCT02375685 Phase 3
26 Extension Study to Assess Safety and Efficacy of AIN457 in Patients With Active Non-infectious Uveitis Terminated NCT01103024 Phase 3
27 Safety and Efficacy Study of Gevokizumab to Treat Non-infectious Uveitis Controlled With Systemic Treatment Terminated NCT01747538 Phase 3 Placebo;Dose 1 gevokizumab;Dose 2 gevokizumab
28 Safety and Efficacy Study of Gevokizumab to Treat Active Non-infectious Uveitis Terminated NCT01684345 Phase 3 Placebo;Dose 1 gevokizumab;Dose 2 gevokizumab
29 An Open-label, Rollover Study Providing Continued Dosing of Gevokizumab in Order to Assess Long-term Gevokizumab Safety Data Terminated NCT02258854 Phase 3 Dose 2 gevokizumab
30 Safety and Efficacy of AIN457 in Patients With Quiescent Non-infectious Uveitis Terminated NCT01090310 Phase 3 AIN457;Placebo
31 Study to Evaluate the Long Term Use of Treatment With AIN457 for Uveitis Withdrawn NCT01327664 Phase 3
32 Study of the Safety, Tolerability, and Bioactivity of Tocilizumab On Patients With Non-infectious UVEITIS: The STOP-UVEITIS Study Unknown status NCT01717170 Phase 1, Phase 2 Tocilizumab
33 Safety, Tolerability, and Efficacy of AEB071 in the Treatment of Uveitis Completed NCT00615693 Phase 2 AEB071
34 Safety,Tolerability and Efficacy of Intravitreal LFG316 in Patients With Active Non-infectious Intermediate-, posterior-or Panuveitis , Completed NCT01526889 Phase 2 LFG316;Conventional Therapy
35 Safety Study of Suprachoroidal Triamcinolone Acetonide Via Microneedle to Treat Uveitis Completed NCT01789320 Phase 1, Phase 2 triamcinolone acetonide (Triesence®)
36 Use of Cross-linked Donor Corneas as Carriers for the Boston Keratoprosthesis Completed NCT01582880 Phase 1, Phase 2 Riboflavin
37 Topical Interferon Gamma for Macular Edema Secondary to Uveitis Completed NCT01376362 Phase 1, Phase 2 Interferon Gamma-1b
38 Suprachoroidal Injection of Triamcinolone Acetonide in Subjects With Macular Edema Following Non-Infectious Uveitis Completed NCT02255032 Phase 2 4 mg CLS-TA;0.8 mg CLS-TA
39 Intravitreal Infliximab in Refractory Uveitis in Behcet's Disease: A Safety and Efficacy Clinical Study Completed NCT02620618 Phase 1, Phase 2 Intravitreal Infliximab
40 Safety and Efficacy of AIN457 in Noninfectious Uveitis Completed NCT00685399 Phase 2 AIN457;AIN 457;AIN457
41 Leflunomide to Treat Uveitis Completed NCT00001863 Phase 2 Leflunomide
42 Intravitreal Sirolimus as Therapeutic Approach to Uveitis Recruiting NCT01280669 Phase 2 Intravitreal injection 440mcg;Intravitreal injection of sirolimus 880mcg
43 Ustekinumab (STELARA) for the Treatment of Active Sight-Threatening Uveitis (STAR Study) Recruiting NCT02911116 Phase 2 Ustekinumab
44 ACTH as A Re-emerging theRapy for Uveitis (The ACTHAR Study) Recruiting NCT02931175 Phase 2 ACTH gel
45 Vision Restoration With a Collagen Crosslinked Boston Keratoprosthesis Unit Recruiting NCT02863809 Phase 1, Phase 2 Riboflavin;Dextran
46 A Multicenter Phase 2 Single-arm Proof-of-concept Trial to Assess the Efficacy and Safety of Ustekinumab in Association With Prednisone for the Treatment of Non-infectious Severe Uveitis (NISU) Not yet recruiting NCT03847272 Phase 2 prednisone and ustekinumab treatment
47 Safety and Preliminary Efficacy Study of V404 PDS in Uveitis Terminated NCT02125266 Phase 1, Phase 2 V404
48 Safety &Efficacy of CF101 to Subjects With Uveitis Withdrawn NCT01905124 Phase 2 CF101;Placebo
49 A Phase I/IIa Study for the Treatment of Uveitis With Iontophoresis Withdrawn NCT00499551 Phase 1, Phase 2
50 Sirolimus as Therapeutic Approach to Uveitis Completed NCT00908466 Phase 1 Sirolimus (rapamycin);Sirolimus (rapamycin)

Search NIH Clinical Center for Intermediate Uveitis

Cochrane evidence based reviews: uveitis, intermediate

Genetic Tests for Intermediate Uveitis

Anatomical Context for Intermediate Uveitis

MalaCards organs/tissues related to Intermediate Uveitis:

42
Eye, Retina, Lung, Heart, T Cells, Endothelial, Thyroid

Publications for Intermediate Uveitis

Articles related to Intermediate Uveitis:

(show top 50) (show all 187)
# Title Authors Year
1
Comparative efficacy between adalimumab and infliximab in the treatment of non-infectious intermediate uveitis, posterior uveitis, and panuveitis: a retrospective observational study of 107 patients. ( 30099655 )
2019
2
Swept-source optical coherence tomography angiography reveals vascular changes in intermediate uveitis. ( 30729711 )
2019
3
Chikungunya Virus Infection Manifesting as Intermediate Uveitis. ( 28010143 )
2018
4
Primary Glomerulonephritis with Unique C4d Deposition and Concurrent Non-infectious Intermediate Uveitis: a Case Report and Literature Review. ( 29713256 )
2018
5
Ocular Siderosis Subsequent to a Missed Pars Plana Metallic Foreign Body that Masqueraded as Refractory Intermediate Uveitis. ( 27849408 )
2018
6
Use of Immunosuppressive Medications for Treatment of Pediatric Intermediate Uveitis. ( 27960602 )
2018
7
Cystoid Macular Edema in Retinitis Pigmentosa with Intermediate Uveitis Responded Well to Oral and Posterior Subtenon Steroid. ( 28353369 )
2018
8
Long-term results of pars plana vitrectomy as an anti-inflammatory therapy of pediatric intermediate uveitis resistant to standard medical treatment. ( 28862736 )
2018
9
Enteric-coated mycophenolate sodium in the treatment of non-infectious intermediate uveitis: results of a prospective, controlled, randomised, open-label, early terminated multicentre trial. ( 28903965 )
2018
10
Disease Remission in Children and Adolescents with Intermediate Uveitis: A Survival Analysis. ( 29241207 )
2018
11
Complications in Intermediate Uveitis: Prevalence, Time of Onset, and Effects on Vision in Short-Term and Long-Term Follow-Up. ( 29370567 )
2018
12
Efficacy of Natalizumab in Intermediate Uveitis Related to Multiple Sclerosis: A Case Report. ( 29452449 )
2018
13
Efficacy and Safety of Mycophenolate Mofetil in the Treatment of Recalcitrant Intermediate Uveitis. ( 29652198 )
2018
14
Optical Coherence Tomography Angiography in Intermediate Uveitis. ( 30026083 )
2018
15
Anterior and Intermediate Uveitis Following Yellow Fever Vaccination with Fractional Dose: Case Reports. ( 30153765 )
2018
16
Evaluation of vascular changes in intermediate uveitis and retinal vasculitis using swept-source wide-field optical coherence tomography angiography. ( 30538102 )
2018
17
Amblyopia due to intermediate uveitis as the presenting symptom of Crohn's disease in a 6-year-old boy. ( 29102673 )
2017
18
INTERMEDIATE UVEITIS ASSOCIATED WITH PERIODIC FEVER, APHTHOUS STOMATITIS, PHARYNGITIS, AND CERVICAL ADENITIS SYNDROME. ( 28570435 )
2017
19
Listeria Monocytogenes Endophthalmitis after Intermediate Uveitis and ppV for Retinal Detachment. ( 28329887 )
2017
20
INFLIXIMAB THERAPY IN PATIENTS WITH NONINFECTIOUS INTERMEDIATE UVEITIS RESISTANT TO CONVENTIONAL IMMUNOMODULATORY THERAPY. ( 27681002 )
2017
21
Predictors of Long-Term Visual Outcome in Intermediate Uveitis. ( 28017424 )
2017
22
Association between intermediate uveitis and toxocariasis in the Korean population. ( 28151857 )
2017
23
Re: Jaffe et al.: Injectable fluocinolone acetonide long-acting implant for noninfectious intermediate uveitis, posterior uveitis, and panuveitis: two-year results (Ophthalmology. 2016;123:1940-1948). ( 28335961 )
2017
24
Effect of Adalimumab on Visual Functioning in Patients With Noninfectious Intermediate Uveitis, Posterior Uveitis, and Panuveitis in the VISUAL-1 and VISUAL-2 Trials. ( 28426849 )
2017
25
Intermediate uveitis: pattern of etiology, complications, treatment and outcome in a tertiary academic center. ( 28449695 )
2017
26
Preoperative Inflammatory Control and Surgical Outcome of Vitrectomy in Intermediate Uveitis. ( 28465834 )
2017
27
PERIPHERAL RETINOSCHISIS IN INTERMEDIATE UVEITIS. ( 28590967 )
2017
28
Re: Niederer et al.: Predictors of long-term visual outcome in intermediate uveitis (Ophthalmology. 2017;124:393-398). ( 28645347 )
2017
29
Re: Jaffe et al.: Injectable fluocinolone acetonide long-acting implant for noninfectious intermediate uveitis, posterior uveitis, and panuveitis: 2-year results (Ophthalmology. 2016;123:1940-1948). ( 28734339 )
2017
30
Patterns of Intermediate Uveitis in Children Presenting at a Tertiary Eye Care Center in South India. ( 28936054 )
2017
31
Ultra-Widefield Fluorescein Angiography in Intermediate Uveitis. ( 29040047 )
2017
32
A systematic review and economic evaluation of adalimumab and dexamethasone for treating non-infectious intermediate uveitis, posterior uveitis or panuveitis in adults. ( 29183563 )
2017
33
In Response to Laovirojjanakul W, Acharya N and Gonzales JA's "Ultra-Widefield Fluorescein Angiography in Intermediate Uveitis". ( 29283787 )
2017
34
Discrepancy in Fluorescein Angiography and Optical Coherence Tomography Findings of Macular Edema in Intermediate Uveitis. ( 26645484 )
2016
35
Risk of Ocular Complications in Patients with Noninfectious Intermediate Uveitis, Posterior Uveitis, or Panuveitis. ( 26712559 )
2016
36
Anterior and Intermediate Uveitis with Retinal Vasculitis: An Unusual Manifestation of Post-Streptococcal Uveitis Syndrome. ( 26713592 )
2016
37
Remission of Intermediate Uveitis: Incidence and Predictive Factors. ( 26772874 )
2016
38
Associations of Systemic Diseases with Intermediate Uveitis. ( 26786193 )
2016
39
Influence of baseline demographic and clinical characteristics in the visual outcome of intermediate uveitis: a survival analysis. ( 27030281 )
2016
40
Bilateral intermediate uveitis with appearance of frosted branch angiitis and association with Mycoplasma pneumoniae infection: case report and review of the literature. ( 27132140 )
2016
41
Retinal Dystrophy in 6 Young Patients Who Presented with Intermediate Uveitis. ( 27157150 )
2016
42
A cross-sectional study of submacular thickening in intermediate uveitis and determination of treatment threshold. ( 27188332 )
2016
43
Ultra-wide Field Fluorescein Angiography in Retinitis Pigmentosa with Intermediate Uveitis. ( 27413510 )
2016
44
Injectable Fluocinolone Acetonide Long-Acting Implant for Noninfectious Intermediate Uveitis, Posterior Uveitis, and Panuveitis: Two-Year Results. ( 27421623 )
2016
45
Peripheral Vasculitis, Intermediate Uveitis and Interferon Use in Multiple Sclerosis. ( 27800257 )
2016
46
Phenotypic changes of peripheral blood mononuclear cells upon corticosteroid treatment in idiopathic intermediate uveitis. ( 27989897 )
2016
47
Chronic candida endophthalmitis as a cause of intermediate uveitis. ( 25870216 )
2015
48
Intermediate uveitis associated with familial Mediterranean fever. ( 26487035 )
2015
49
Possession of the HLA-DRB1*1501 allele and visual outcome in idiopathic intermediate uveitis. ( 25634309 )
2015
50
Association analysis of TGFBR3 gene with Behçet's disease and idiopathic intermediate uveitis in a Caucasian population. ( 25677673 )
2015

Variations for Intermediate Uveitis

Expression for Intermediate Uveitis

Search GEO for disease gene expression data for Intermediate Uveitis.

Pathways for Intermediate Uveitis

Pathways related to Intermediate Uveitis according to GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.66 CXCR3 IL10 IL2 IL2RA IL6 TGFBR3
2
Show member pathways
13.5 CXCR3 IL10 IL2 IL2RA IL6 TNF
3
Show member pathways
13.37 IL10 IL2 IL2RA IL6 TGFBR3 TNF
4
Show member pathways
13.23 CXCR3 IL10 IL2 IL2RA IL6 TNF
5
Show member pathways
13.18 HLA-B IL10 IL2 IL2RA IL6 TNF
6
Show member pathways
12.94 IL10 IL2 IL6 TNF
7
Show member pathways
12.93 CXCR3 IL10 IL2 IL2RA IL6 TGFBR3
8
Show member pathways
12.91 IL2 IL2RA IL6 TGFBR3
9
Show member pathways
12.9 IL2 IL2RA IL6 TGFBR3
10
Show member pathways
12.85 HLA-B IL2 IL2RA IL6 TNF
11
Show member pathways
12.67 HLA-B IL10 IL2 IL2RA IL6 TNF
12
Show member pathways
12.66 IL2 IL2RA IL6 TNF
13
Show member pathways
12.53 IL10 IL2 IL2RA TNF
14
Show member pathways
12.49 IL10 IL2 IL6 TNF
15 12.46 IL10 IL2 IL2RA TNF
16
Show member pathways
12.45 IL10 IL2 IL6 TNF
17
Show member pathways
12.41 IL10 IL2 IL2RA IL6 TNF
18
Show member pathways
12.32 IL2 IL2RA TGFBR3
19
Show member pathways
12.3 IL10 IL2 IL2RA IL6
20
Show member pathways
12.21 IL2 IL6 TNF
21 12.17 HLA-B IL2 IL2RA IL6 TNF
22 12.12 IL10 IL6 TNF
23 12.08 IL10 IL6 TNF
24
Show member pathways
12.06 IL10 IL2 IL6 TNF
25
Show member pathways
11.98 IL10 IL2 IL2RA IL6
26 11.93 IL2 IL6 TNF
27
Show member pathways
11.93 IL10 IL2 IL6 TNF
28 11.91 IL10 IL6 TNF
29 11.83 IL2RA IL6 TNF
30 11.82 IL10 IL6 TNF
31 11.74 IL10 IL2 IL2RA IL6
32
Show member pathways
11.7 IL2 IL2RA TNF
33 11.69 IL10 IL6 TNF
34 11.62 IL10 IL2 IL2RA IL6 TNF
35
Show member pathways
11.6 IL2 IL6 TNF
36
Show member pathways
11.58 IL2 IL2RA TNF
37 11.57 IL10 IL2 IL6 TNF
38 11.52 IL10 IL2 IL6 TNF
39 11.48 IL2 IL6 TNF
40 11.45 IL10 IL6 TNF
41 11.44 IL10 IL6 TNF
42 11.41 IL10 IL2 IL2RA
43
Show member pathways
11.38 HLA-B IL10 IL2 IL2RA IL6 TGFBR3
44 11.29 IL10 IL6 TNF
45 11.26 IL10 IL6 TNF
46 11.26 CXCR3 IL10 IL2 IL2RA TNF
47 11.23 IL2 IL2RA
48 11.22 IL6 TNF
49 11.2 IL6 TNF
50 11.15 IL2 IL2RA

GO Terms for Intermediate Uveitis

Cellular components related to Intermediate Uveitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.26 CXCR3 IL2RA TGFBR3 TNF
2 cell surface GO:0009986 9.02 CXCR3 HLA-B IL2RA TGFBR3 TNF

Biological processes related to Intermediate Uveitis according to GeneCards Suite gene sharing:

(show all 32)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.87 IL10 IL2 IL6 TNF
2 MAPK cascade GO:0000165 9.82 IL2 IL2RA TNF
3 inflammatory response GO:0006954 9.8 CXCR3 IL10 IL6 TNF
4 cellular response to lipopolysaccharide GO:0071222 9.78 IL10 IL6 TNF
5 positive regulation of DNA-binding transcription factor activity GO:0051091 9.71 IL10 IL6 TNF
6 negative regulation of inflammatory response GO:0050728 9.7 IL10 IL2 IL2RA
7 negative regulation of T cell proliferation GO:0042130 9.65 IL10 IL2RA
8 negative regulation of mitotic cell cycle GO:0045930 9.65 IL10 TNF
9 negative regulation of interleukin-6 production GO:0032715 9.64 IL10 TNF
10 positive regulation of cytokine secretion GO:0050715 9.64 IL10 TNF
11 regulation of synapse organization GO:0050807 9.63 IL10 TNF
12 positive regulation of activated T cell proliferation GO:0042104 9.63 IL2 IL2RA
13 negative regulation of neurogenesis GO:0050768 9.62 IL6 TNF
14 positive regulation of chemokine production GO:0032722 9.62 IL6 TNF
15 positive regulation of T cell differentiation GO:0045582 9.61 IL2 IL2RA
16 positive regulation of glial cell proliferation GO:0060252 9.6 IL6 TNF
17 regulation of regulatory T cell differentiation GO:0045589 9.59 IL2 IL2RA
18 negative regulation of growth of symbiont in host GO:0044130 9.58 IL10 TNF
19 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.58 IL10 TNF
20 positive regulation of immunoglobulin secretion GO:0051024 9.56 IL2 IL6
21 interleukin-2-mediated signaling pathway GO:0038110 9.55 IL2 IL2RA
22 response to glucocorticoid GO:0051384 9.54 IL10 IL6 TNF
23 negative regulation of lipid storage GO:0010888 9.51 IL6 TNF
24 positive regulation of T cell proliferation GO:0042102 9.5 IL2 IL2RA IL6
25 endothelial cell apoptotic process GO:0072577 9.48 IL10 TNF
26 negative regulation of cytokine secretion involved in immune response GO:0002740 9.46 IL10 TNF
27 negative regulation of lymphocyte proliferation GO:0050672 9.43 IL2 IL2RA
28 positive regulation of neuroinflammatory response GO:0150078 9.4 IL6 TNF
29 cytokine-mediated signaling pathway GO:0019221 9.35 IL10 IL2 IL2RA IL6 TNF
30 receptor biosynthetic process GO:0032800 9.26 IL10 TNF
31 immune response GO:0006955 9.23 CXCR3 HLA-B IL10 IL2 IL2RA IL6
32 regulation of T cell homeostatic proliferation GO:0046013 9.16 IL2 IL2RA

Molecular functions related to Intermediate Uveitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.13 IL10 IL2 IL6
2 cytokine activity GO:0005125 8.92 IL10 IL2 IL6 TNF

Sources for Intermediate Uveitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
Content
Loading form....