MCID: INT025
MIFTS: 39

Intermittent Explosive Disorder

Categories: Mental diseases

Aliases & Classifications for Intermittent Explosive Disorder

MalaCards integrated aliases for Intermittent Explosive Disorder:

Name: Intermittent Explosive Disorder 12 15 71
Explosive Personality Disorder 12 71

Classifications:



External Ids:

Disease Ontology 12 DOID:12401
ICD9CM 34 301.3 312.34
MeSH 44 D007174
NCIt 50 C94332
SNOMED-CT 67 192096007 268757006
ICD10 32 F60.3 F63.81
UMLS 71 C0021776 C0152183

Summaries for Intermittent Explosive Disorder

Disease Ontology : 12 An impulse control disorder that involves the episodic inability to control violent impulses with a disproportionate degree of aggressiveness.

MalaCards based summary : Intermittent Explosive Disorder, also known as explosive personality disorder, is related to post-traumatic stress disorder and eating disorder. An important gene associated with Intermittent Explosive Disorder is SLC6A4 (Solute Carrier Family 6 Member 4), and among its related pathways/superpathways are Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways and Serotonergic synapse. The drugs Guanfacine and Adrenergic alpha-Agonists have been mentioned in the context of this disorder. Affiliated tissues include brain, amygdala and temporal lobe.

Wikipedia : 74 Intermittent explosive disorder (sometimes abbreviated as IED) is a behavioral disorder characterized by... more...

Related Diseases for Intermittent Explosive Disorder

Diseases related to Intermittent Explosive Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 130)
# Related Disease Score Top Affiliating Genes
1 post-traumatic stress disorder 30.4 SLC6A4 MAOA HTR2A COMT
2 eating disorder 30.1 SLC6A4 HTR2C COMT
3 personality disorder 30.0 SLC6A4 MAOA HTR2C HTR2A HTR1A COMT
4 conduct disorder 30.0 SLC6A4 MAOA COMT
5 obsessive-compulsive personality disorder 30.0 SLC6A4 HTR2A COMT
6 paraphilia disorder 29.9 OXT MAOA
7 acute stress disorder 29.9 SLC6A4 OXT HTR1A
8 depression 29.8 SLC6A4 MAOA HTR2C HTR2A HTR1A
9 alcohol use disorder 29.6 SLC6A4 HTR2C HTR2A HTR1A COMT
10 generalized anxiety disorder 29.6 SLC6A4 MAOA HTR2A HTR1A COMT
11 mood disorder 29.5 SLC6A4 MAOA HTR2C HTR2A HTR1A COMT
12 impulse control disorder 29.5 SLC6A4 MAOA HTR2C HTR2A HTR1A COMT
13 bipolar disorder 29.4 SLC6A4 MAOA HTR2C HTR2A HTR1A COMT
14 substance abuse 29.4 SLC6A4 MAOA HTR2A HTR1A COMT
15 borderline personality disorder 29.3 SLC6A4 MAOA HTR2C HTR2A HTR1A COMT
16 alexithymia 29.3 SLC6A4 OXT HTR1A COMT
17 agoraphobia 29.2 SLC6A4 MAOA HTR2A HTR1A CTU2 COMT
18 oppositional defiant disorder 29.1 SLC6A4 OXT MAOA HTR2A COMT
19 antisocial personality disorder 29.1 SLC6A4 OXT MAOA HTR2A COMT
20 alcohol dependence 29.1 SLC6A4 MAOA HTR2C HTR2A HTR1A COMT
21 bulimia nervosa 29.0 SLC6A4 OXT MAOA HTR2C HTR2A COMT
22 mental depression 28.7 SLC6A4 OXT MAOA HTR2C HTR2A HTR1A
23 major depressive disorder 28.6 SLC6A4 OXT MAOA HTR2C HTR2A HTR1A
24 attention deficit-hyperactivity disorder 28.6 SLC6A4 OXT MAOA HTR2C HTR2A HTR1A
25 anxiety 28.4 SLC6A4 OXT MAOA HTR2C HTR2A HTR1A
26 anorexia nervosa 28.4 SLC6A4 OXT MAOA HTR2C HTR2A HTR1A
27 obsessive-compulsive disorder 28.4 SLC6A4 OXT MAOA HTR2C HTR2A HTR1A
28 pyromania 11.2
29 avoidant personality disorder 10.4
30 severe combined immunodeficiency 10.3
31 major affective disorder 8 10.2
32 major affective disorder 9 10.2
33 alcoholic psychosis 10.2 SLC6A4 HTR2A
34 corneal dystrophy, lisch epithelial 10.2 MAOA HTR1A
35 retrograde amnesia 10.1 SLC6A4 HTR1A
36 diamond-blackfan anemia 5 10.1 SLC6A4 HTR1A
37 tardive dyskinesia 10.0 HTR2A COMT
38 conversion disorder 10.0 HTR2A COMT
39 brunner syndrome 10.0 SLC6A4 MAOA COMT
40 oculogyric crisis 10.0 HTR2A HTR1A
41 sleep apnea 10.0 SLC6A4 HTR2C HTR2A
42 prader-willi syndrome 10.0
43 coronary heart disease 1 10.0
44 asymptomatic neurosyphilis 10.0
45 neutropenia 10.0
46 craniopharyngioma 10.0
47 syphilis 10.0
48 tertiary syphilis 10.0
49 lung disease 10.0
50 48,xyyy 10.0

Comorbidity relations with Intermittent Explosive Disorder via Phenotypic Disease Network (PDN):


Acute Cystitis Alzheimer Disease
Schizophreniform Disorder

Graphical network of the top 20 diseases related to Intermittent Explosive Disorder:



Diseases related to Intermittent Explosive Disorder

Symptoms & Phenotypes for Intermittent Explosive Disorder

Drugs & Therapeutics for Intermittent Explosive Disorder

Drugs for Intermittent Explosive Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Guanfacine Approved, Investigational Phase 4 29110-47-2 3519
2 Adrenergic alpha-Agonists Phase 4
3 Antihypertensive Agents Phase 4
4 Adrenergic Agents Phase 4
5 Neurotransmitter Agents Phase 4
6 Adrenergic Agonists Phase 4
7
Fluoxetine Approved, Vet_approved Phase 2 54910-89-3 3386
8
Valproic acid Approved, Investigational Phase 2 99-66-1 3121
9
Quinidine Approved, Investigational Phase 2 56-54-2 441074
10 Hormones Phase 1, Phase 2
11 Arginine Vasopressin Phase 1, Phase 2
12 SRX246 Phase 1, Phase 2
13 Vasopressins Phase 1, Phase 2
14 Antidepressive Agents Phase 2
15 Cytochrome P-450 Enzyme Inhibitors Phase 2
16 Serotonin Uptake Inhibitors Phase 2
17 Psychotropic Drugs Phase 2
18 Anticonvulsants Phase 2
19 Quinidine gluconate Phase 2
20
Serotonin Investigational, Nutraceutical Phase 2 50-67-9 5202

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Intuniv vs Placebo in the Treatment of Childhood Intermittent Explosive Disorder Completed NCT02048241 Phase 4 Intuniv
2 An Exploratory Phase II Study to Determine the Safety, Tolerability and Activity of a Novel Vasopressin 1a Receptor Antagonist (SRX246) in Adults With Diagnostic and Statistical Manual Version 5 (DSM-5) Intermittent Explosive Disorder (IED) Completed NCT02055638 Phase 1, Phase 2 SRX246;Placebo
3 Fluoxetine and Divalproex: Treatment Correlates in IED Completed NCT00078754 Phase 2 Fluoxetine;Divalproex;Placebo
4 A Pilot Study Comparing the Efficacy of Group Versus Individual Anger Management in Subjects With Intermittent Explosive Disorder Completed NCT00127400 Phase 2
5 Individual Cognitive Behavioral Psychotherapy for Intermittent Explosive Disorder Completed NCT00667212 Phase 2
6 A Phase 2, Multicenter, Randomized, Double-blind, Placebo-controlled Study to Assess the Efficacy, Safety, and Tolerability of AVP-786 (Deudextromethorphan Hydrobromide [d6-DM]/Quinidine Sulfate [Q]) for the Treatment of Intermittent Explosive Disorder (IED) Terminated NCT03420222 Phase 2 AVP-786;Placebo

Search NIH Clinical Center for Intermittent Explosive Disorder

Genetic Tests for Intermittent Explosive Disorder

Anatomical Context for Intermittent Explosive Disorder

MalaCards organs/tissues related to Intermittent Explosive Disorder:

40
Brain, Amygdala, Temporal Lobe

Publications for Intermittent Explosive Disorder

Articles related to Intermittent Explosive Disorder:

(show top 50) (show all 290)
# Title Authors PMID Year
1
Evidence for the taxonic latent structure for DSM-5 intermittent explosive disorder in adults. 61
31680661 2021
2
Aggressive behavior in psychiatric patients in relation to hormonal imbalance (Review). 61
32905000 2020
3
Differentiating irritable mood and disruptive behavior in adults. 61
33295573 2020
4
Self-injurious thoughts and behaviors that differentiate soldiers who attempt suicide from those with recent suicide ideation. 61
32291817 2020
5
The association between adverse childhood experiences and mental health problems in young offenders. 61
32740721 2020
6
ADHD symptom profiles, intermittent explosive disorder, adverse childhood experiences, and internalizing/externalizing problems in young offenders. 61
32780159 2020
7
Predictors of suicide attempt in patients with obsessive-compulsive disorder: an exploratory study with machine learning analysis. 61
32669156 2020
8
Traumatic Stress Induces Prolonged Aggression Increase through Synaptic Potentiation in the Medial Amygdala Circuits. 61
32651265 2020
9
Dimensions over categories: a meta-analysis of taxometric research. 61
32493520 2020
10
History of childhood abuse and alcohol use disorder: Relationship with intermittent explosive disorder and intoxicated aggression frequency. 61
32203738 2020
11
Intermittent explosive disorder subtypes in the general population: association with comorbidity, impairment and suicidality. 61
32638683 2020
12
Neuropsychiatric Aspects of Impulse Control Disorders. 61
32439020 2020
13
The Overt Aggression Scale Modified (OAS-M) for clinical trials targeting impulsive aggression and intermittent explosive disorder: Validity, reliability, and correlates. 61
32114032 2020
14
Prevalence and psychiatric comorbidities of intermittent explosive disorders in Metropolitan São Paulo, Brazil. 61
32285139 2020
15
Disordered Aggression and Violence in the United States. 61
32220154 2020
16
Risk for Misdiagnosing Chronic Traumatic Encephalopathy in Men With Anger Control Problems. 61
32849206 2020
17
Comorbidity of disruptive behavior disorders and intermittent explosive disorder. 61
32514306 2020
18
Gray Matter Deficits and Dysfunction in the Insula Among Individuals With Intermittent Explosive Disorder. 61
32508687 2020
19
Neurosyphilis Presenting as Intermittent Explosive Disorder and Acute Psychosis. 61
31938625 2019
20
Psychiatric comorbidity in Intermittent Explosive Disorder. 61
31487607 2019
21
5-HT2c agonist, lorcaserin, reduces aggressive responding in intermittent explosive disorder: A pilot study. 61
31774584 2019
22
Habenula-prefrontal resting-state connectivity in reactive aggressive men - A pilot study. 61
30366001 2019
23
Comorbidity profile of mental disorders among adolescents: A latent class analysis. 61
31226549 2019
24
Aggression directed towards others vs. aggression directed towards the self: clinical differences between intermittent explosive disorder and nonsuicidal self-injury. 61
30843959 2019
25
Compulsive sexual behavior disorder in obsessive-compulsive disorder: Prevalence and associated comorbidity. 61
31079471 2019
26
Scales to assess impulsive and compulsive behaviors in Parkinson's disease: Critique and recommendations. 61
31136681 2019
27
Transition to suicide attempt from recent suicide ideation in U.S. Army soldiers: Results from the Army Study to Assess Risk and Resilience in Servicemembers (Army STARRS). 61
30549394 2019
28
Emotion processing in intermittent explosive disorder. 61
30710810 2019
29
Prior Mental Disorders and Lifetime Suicidal Behaviors Among US Army Soldiers in the Army Study to Assess Risk and Resilience in Servicemembers (Army STARRS). 61
28926674 2019
30
Subtypes of aggression in intermittent explosive disorder. 61
30551023 2019
31
Intermittent Explosive Disorder in Male Juvenile Delinquents in China. 61
31404282 2019
32
Potential Deep Brain Stimulation Targets for the Management of Refractory Hypertension. 61
30858796 2019
33
Relationship between quality of life in young adults and impulsivity/compulsivity✰. 61
30504061 2019
34
Social desirability, deceptive reporting, and awareness of problematic aggression in intermittent explosive disorder compared with non-aggressive healthy and psychiatric controls. 61
30243128 2018
35
The co-occurrence and correlates of anxiety disorders among adolescents with intermittent explosive disorder. 61
30040122 2018
36
Comorbidity of personality disorder with intermittent explosive disorder. 61
30240963 2018
37
Suicidal behavior and aggression-related disorders. 61
28829989 2018
38
Cognitive-behavioral group therapy for intermittent explosive disorder: description and preliminary analysis. 61
29590263 2018
39
DSM-5 intermittent explosive disorder: Relationship with Disruptive Mood Dysregulation Disorder. 61
29753187 2018
40
Psychosocial impairment in DSM-5 intermittent explosive disorder. 61
29627702 2018
41
Construct validity and parent-child agreement of the six new or modified disorders included in the Spanish version of the Kiddie Schedule for Affective Disorders and Schizophrenia present and Lifetime Version DSM-5 (K-SADS-PL-5). 61
29529472 2018
42
Prevalence and clinical correlates of intermittent explosive disorder in Turkish psychiatric outpatients. 61
29604524 2018
43
Aggression is associated with greater subsequent alcohol consumption: A shared neural basis in the ventral striatum. 61
29417595 2018
44
Major depressive disorder and depressive symptoms in intermittent explosive disorder. 61
29455060 2018
45
Prader-Willi syndrome genetic subtypes and clinical neuropsychiatric diagnoses in residential care adults. 61
28984907 2018
46
Treatment of Intermittent Explosive Disorder With Carbamazepine. 61
29533363 2018
47
Mild Traumatic Brain Injury and Aggression, Impulsivity, and History of Other- and Self-Directed Aggression. 61
29505319 2018
48
Genome-Wide DNA Methylation Changes Associated with Intermittent Explosive Disorder: A Gene-Based Functional Enrichment Analysis. 61
29106553 2018
49
A wait-list controlled study of a trauma-focused cognitive behavioral treatment for intermittent explosive disorder in Timor-Leste. 61
28749158 2018
50
Problematic internet use in gamblers: impact on clinical and cognitive measures. 61
28893336 2017

Variations for Intermittent Explosive Disorder

Expression for Intermittent Explosive Disorder

Search GEO for disease gene expression data for Intermittent Explosive Disorder.

Pathways for Intermittent Explosive Disorder

Pathways related to Intermittent Explosive Disorder according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.83 SLC6A4 MAOA HTR2A HTR1A
2 11.61 SLC6A4 MAOA HTR2C HTR2A HTR1A
3
Show member pathways
11.59 HTR2C HTR2A HTR1A
4
Show member pathways
10.83 SLC6A4 MAOA COMT
5
Show member pathways
10.82 MAOA COMT
6 10.76 HTR2C HTR2A
7
Show member pathways
10.64 MAOA COMT
8
Show member pathways
10.62 SLC6A4 MAOA HTR1A COMT
9 10.55 MAOA COMT
10 10.47 SLC6A4 MAOA HTR2C HTR2A HTR1A

GO Terms for Intermittent Explosive Disorder

Cellular components related to Intermittent Explosive Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 dendrite GO:0030425 9.46 HTR2C HTR2A HTR1A COMT
2 synapse GO:0045202 9.35 ZNRF1 SLC6A4 HTR2C HTR2A HTR1A
3 G protein-coupled serotonin receptor complex GO:0098666 8.62 HTR2C HTR2A

Biological processes related to Intermittent Explosive Disorder according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.78 SLC6A4 HTR2C HTR2A COMT
2 memory GO:0007613 9.61 SLC6A4 OXT HTR2A
3 release of sequestered calcium ion into cytosol GO:0051209 9.57 HTR2C HTR2A
4 regulation of sensory perception of pain GO:0051930 9.56 OXT COMT
5 behavioral fear response GO:0001662 9.55 HTR2C HTR1A
6 vasoconstriction GO:0042310 9.54 SLC6A4 HTR1A
7 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 9.54 HTR2C HTR2A HTR1A
8 catecholamine metabolic process GO:0006584 9.52 MAOA COMT
9 neurotransmitter catabolic process GO:0042135 9.51 MAOA COMT
10 sleep GO:0030431 9.49 OXT HTR2A
11 dopamine catabolic process GO:0042420 9.46 MAOA COMT
12 serotonin receptor signaling pathway GO:0007210 9.4 HTR2A HTR1A
13 sperm ejaculation GO:0042713 9.32 SLC6A4 OXT
14 positive regulation of phosphatidylinositol biosynthetic process GO:0010513 9.26 HTR2C HTR2A
15 phospholipase C-activating serotonin receptor signaling pathway GO:0007208 9.16 HTR2C HTR2A
16 G protein-coupled serotonin receptor signaling pathway GO:0098664 9.13 HTR2C HTR2A HTR1A
17 behavior GO:0007610 8.8 HTR2C HTR2A HTR1A

Molecular functions related to Intermittent Explosive Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neurotransmitter receptor activity GO:0030594 9.5 HTR2C HTR2A HTR1A
2 G protein-coupled serotonin receptor activity GO:0004993 9.33 HTR2C HTR2A HTR1A
3 Gq/11-coupled serotonin receptor activity GO:0001587 9.26 HTR2C HTR2A
4 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding GO:0071886 8.96 HTR2C HTR2A
5 serotonin binding GO:0051378 8.92 SLC6A4 HTR2C HTR2A HTR1A

Sources for Intermittent Explosive Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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