MCID: INT025
MIFTS: 42

Intermittent Explosive Disorder

Categories: Mental diseases

Aliases & Classifications for Intermittent Explosive Disorder

MalaCards integrated aliases for Intermittent Explosive Disorder:

Name: Intermittent Explosive Disorder 12 15 73
Explosive Personality Disorder 12 73

Classifications:



External Ids:

Disease Ontology 12 DOID:12401
ICD10 33 F60.3 F63.81
ICD9CM 35 301.3 312.34
MeSH 44 D007174
NCIt 50 C94332
SNOMED-CT 68 40987004

Summaries for Intermittent Explosive Disorder

Disease Ontology : 12 An impulse control disorder that involves the episodic inability to control violent impulses with a disproportionate degree of aggressiveness.

MalaCards based summary : Intermittent Explosive Disorder, also known as explosive personality disorder, is related to personality disorder and disease of mental health. An important gene associated with Intermittent Explosive Disorder is SLC6A4 (Solute Carrier Family 6 Member 4), and among its related pathways/superpathways are Peptide ligand-binding receptors and G alpha (s) signalling events. The drugs Guanfacine and Naratriptan have been mentioned in the context of this disorder. Affiliated tissues include amygdala, brain and heart, and related phenotypes are homeostasis/metabolism and nervous system

Wikipedia : 76 Intermittent explosive disorder (sometimes abbreviated as IED) is a behavioral disorder characterized by... more...

Related Diseases for Intermittent Explosive Disorder

Diseases related to Intermittent Explosive Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 80)
# Related Disease Score Top Affiliating Genes
1 personality disorder 30.5 HTR1A PRL SLC6A4
2 disease of mental health 30.3 HTR1A HTR7 SLC6A4
3 anxiety 30.0 HTR1A NPY SLC6A4
4 bipolar disorder 30.0 CHRNA7 HTR1A PRL SLC6A4
5 obsessive-compulsive disorder 29.9 HTR1A PRL SLC6A4
6 major depressive disorder 29.4 HTR1A IL6 NPY PRL SLC6A4
7 pyromania 11.2
8 atypical depressive disorder 10.2 HTR7 SLC6A4
9 phobic disorder 10.2 HTR1A SLC6A4
10 dissociative amnesia 10.2 HTR1A SMUG1
11 gastrointestinal tuberculosis 10.2 CRP SMUG1
12 periodic limb movement disorder 10.2 HTR1A SLC6A4
13 aortitis 10.2 CRP SMUG1
14 premature ejaculation 10.2 HTR1A SLC6A4
15 tobacco addiction 10.2 CHRFAM7A CHRNA7 SLC6A4
16 rumination disorder 10.2 HTR1A HTR7
17 dysthymic disorder 10.2 HTR7 SLC6A4
18 cold agglutinin disease 10.1 CRP IL6
19 cartilage disease 10.1 CRP SMUG1
20 cryopyrin-associated periodic syndrome 10.1 CRP IL6
21 alexithymia 10.1 CRP HTR1A SLC6A4
22 acute cholangitis 10.1 CRP IL6
23 psychosexual disorder 10.1 HTR1A HTR7 SLC6A4
24 uremic pruritus 10.1 CRP IL6
25 kleptomania 10.1 HTR1A HTR7 SLC6A4
26 motion sickness 10.1 HTR1A HTR7
27 brunner syndrome 10.1 HTR1A HTR7 SLC6A4
28 mental depression 10.1 HTR1A HTR7 SLC6A4
29 neutrophilia, hereditary 10.1 CRP IL6
30 spinal disease 10.1 CRP IL6
31 viral pneumonia 10.1 CRP IL6
32 chronic fatigue syndrome 10.1 HTR1A IL6 SLC6A4
33 sphenoid sinusitis 10.1 CRP GOLPH3
34 multicentric castleman disease 10.1 CRP IL6
35 coronary artery anomaly 10.1 ADRB1 CRP SMUG1
36 lactocele 10.1 PRL SMUG1
37 melancholia 10.1 CRP PRL
38 pulmonary aspergilloma 10.0 CRP SMUG1
39 relapsing polychondritis 10.0 CRP IL6
40 systolic heart failure 10.0 ADRB1 CRP IL6
41 sexual disorder 10.0 HTR1A PRL SLC6A4
42 subacute thyroiditis 10.0 CRP IL6
43 social phobia 10.0 HTR1A PRL SLC6A4
44 central nervous system vasculitis 10.0 CRP IL6 SMUG1
45 migraine without aura 10.0 HTR1A PRL SLC6A4
46 intussusception 10.0 CRP IL6
47 temporal arteritis 10.0 CRP IL6 SMUG1
48 intestinal disease 10.0 CRP IL6 SMUG1
49 respiratory system disease 10.0 CRP IL6 SMUG1
50 stereotypic movement disorder 10.0 NPY PRL

Comorbidity relations with Intermittent Explosive Disorder via Phenotypic Disease Network (PDN):


Acute Cystitis Alzheimer Disease
Schizophreniform Disorder

Graphical network of the top 20 diseases related to Intermittent Explosive Disorder:



Diseases related to Intermittent Explosive Disorder

Symptoms & Phenotypes for Intermittent Explosive Disorder

MGI Mouse Phenotypes related to Intermittent Explosive Disorder:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.73 ADRB1 CGA CHRNA7 CRP GABRA2 HTR1A
2 nervous system MP:0003631 9.28 CGA CHRNA7 GABRA2 HTR1A HTR7 IL6

Drugs & Therapeutics for Intermittent Explosive Disorder

Drugs for Intermittent Explosive Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 49)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Guanfacine Approved, Investigational Phase 4 29110-47-2 3519
2
Naratriptan Approved, Investigational Phase 4 121679-13-8, 143388-64-1 4440
3
Sumatriptan Approved, Investigational Phase 4 103628-46-2 5358
4 Antihypertensive Agents Phase 4
5 Neurotransmitter Agents Phase 4,Phase 3,Phase 2
6 Adrenergic alpha-Agonists Phase 4
7 Adrenergic alpha-2 Receptor Agonists Phase 4
8 Adrenergic Agonists Phase 4
9 Adrenergic Agents Phase 4
10 Vasoconstrictor Agents Phase 4,Phase 1,Phase 2
11 Serotonin Agents Phase 4,Phase 3,Phase 2
12 Serotonin 5-HT1 Receptor Agonists Phase 4
13
Serotonin Investigational, Nutraceutical Phase 4,Phase 3,Phase 2 50-67-9 5202
14
Dopamine Approved Phase 3 51-61-6, 62-31-7 681
15
Risperidone Approved, Investigational Phase 3 106266-06-2 5073
16
Carbidopa Approved Phase 3 28860-95-9 34359 38101
17
Levodopa Approved Phase 3 59-92-7 6047
18 Antipsychotic Agents Phase 3
19 Psychotropic Drugs Phase 3,Phase 2
20 Serotonin Antagonists Phase 3
21 Dopamine Antagonists Phase 3
22 Central Nervous System Depressants Phase 3,Not Applicable
23 Dopamine Agents Phase 3
24 Tranquilizing Agents Phase 3
25 Immunologic Factors Phase 3
26 Adjuvants, Immunologic Phase 3
27 Dopamine agonists Phase 3
28 Antiparkinson Agents Phase 3
29 Aromatic Amino Acid Decarboxylase Inhibitors Phase 3
30 Carbidopa, levodopa drug combination Phase 3
31
Fluoxetine Approved, Vet_approved Phase 2 54910-89-3 3386
32
Quinidine Approved, Investigational Phase 2 56-54-2 441074
33 SRX246 Phase 1, Phase 2
34 Natriuretic Agents Phase 1, Phase 2
35 Arginine Vasopressin Phase 1, Phase 2
36 Vasopressins Phase 1, Phase 2
37 Hemostatics Phase 1, Phase 2
38 Coagulants Phase 1, Phase 2
39 Hormones Phase 1, Phase 2
40 Antidepressive Agents Phase 2
41 Cytochrome P-450 Enzyme Inhibitors Phase 2
42 Neurotransmitter Uptake Inhibitors Phase 2
43 Serotonin Uptake Inhibitors Phase 2
44 Cytochrome P-450 CYP2D6 Inhibitors Phase 2
45 Antidepressive Agents, Second-Generation Phase 2
46 Quinidine gluconate Phase 2
47
Ethanol Approved Not Applicable 64-17-5 702
48 Anti-Infective Agents, Local Not Applicable
49 Anti-Infective Agents Not Applicable

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Intuniv vs Placebo in the Treatment of Childhood Intermittent Explosive Disorder Completed NCT02048241 Phase 4 Intuniv
2 Efficacy of a Triptan in the Treatment of Hostility and Aggression Among Convicts With a Psychiatric Treatment Order Terminated NCT00282165 Phase 4 naratriptan;placebo
3 Study to Determine Whether There Are Any Cognitive or Motor Effects From Taking the Medicine Risperidone. Completed NCT00399698 Phase 3 Risperdal
4 Safety/Efficacy Study of Levodopa-Carbidopa Intestinal Gel in Parkinson's Subjects Completed NCT00360568 Phase 3 Levodopa-carbidopa intestinal gel
5 Levodopa-Carbidopa Intestinal Gel Open-Label Study in Advanced Parkinson's Disease Completed NCT00335153 Phase 3 Levodopa-carbidopa intestinal gel
6 Safety, Tolerability and Activity of SRX246 in Adults With Intermittent Explosive Disorder Completed NCT02055638 Phase 1, Phase 2 SRX246;Placebo
7 Psychotherapy for Intermittent Explosive Disorder Completed NCT00667212 Phase 2
8 A Comparison of Fluoxetine and Divalproex for the Treatment of Intermittent Explosive Disorder Completed NCT00078754 Phase 2 Fluoxetine;Divalproex;Placebo
9 A Pilot Study Comparing the Efficacy of Group Versus Individual Anger Management in Subjects With IED Completed NCT00127400 Phase 2
10 Study to Assess the Efficacy, Safety, and Tolerability of AVP-786 for the Treatment of Intermittent Explosive Disorder Active, not recruiting NCT03420222 Phase 2 AVP-786;Placebo
11 Alcohol Related Impairment and Reinforcement: Pre to Post Roux en Y Gastric Bypass Surgery Recruiting NCT02370732 Not Applicable

Search NIH Clinical Center for Intermittent Explosive Disorder

Genetic Tests for Intermittent Explosive Disorder

Anatomical Context for Intermittent Explosive Disorder

MalaCards organs/tissues related to Intermittent Explosive Disorder:

41
Amygdala, Brain, Heart, Lymph Node, Thyroid

Publications for Intermittent Explosive Disorder

Articles related to Intermittent Explosive Disorder:

(show top 50) (show all 101)
# Title Authors Year
1
DSM-5 intermittent explosive disorder: Relationship with Disruptive Mood Dysregulation Disorder. ( 29753187 )
2018
2
Major depressive disorder and depressive symptoms in intermittent explosive disorder. ( 29455060 )
2018
3
Treatment of Intermittent Explosive Disorder With Carbamazepine. ( 29533363 )
2018
4
Prevalence and clinical correlates of intermittent explosive disorder in Turkish psychiatric outpatients. ( 29604524 )
2018
5
Cognitive-behavioral group therapy for intermittent explosive disorder: description and preliminary analysis. ( 29590263 )
2018
6
Genome-Wide DNA Methylation Changes Associated with Intermittent Explosive Disorder: A Gene-Based Functional Enrichment Analysis. ( 29106553 )
2018
7
Psychosocial impairment in DSM-5 intermittent explosive disorder. ( 29627702 )
2018
8
The co-occurrence and correlates of anxiety disorders among adolescents with intermittent explosive disorder. ( 30040122 )
2018
9
Comorbidity of personality disorder with intermittent explosive disorder. ( 30240963 )
2018
10
Social desirability, deceptive reporting, and awareness of problematic aggression in intermittent explosive disorder compared with non-aggressive healthy and psychiatric controls. ( 30243128 )
2018
11
Subtypes of aggression in intermittent explosive disorder. ( 30551023 )
2018
12
Intermittent explosive disorder and eating disorders: Analysis of national comorbidity and research samples. ( 28324677 )
2017
13
Intermittent Explosive Disorder and Substance Use Disorder: Analysis of the National Comorbidity Survey Replication Sample. ( 28252880 )
2017
14
A Wait-List Controlled Study of a Trauma-Focused Cognitive Behavioral Treatment for Intermittent Explosive Disorder in Timor-Leste. ( 28749158 )
2017
15
Negative urgency and reward/punishment sensitivity in intermittent explosive disorder. ( 27155024 )
2016
16
Social cognition in Intermittent Explosive Disorder and aggression. ( 27621104 )
2016
17
Amygdala hyperactivation to angry faces in intermittent explosive disorder. ( 27145325 )
2016
18
Single Case Study: Neuropsychological Functioning in a Patient Diagnosed with Intermittent Explosive Disorder Pre and Post Neurosurgery. ( 27161981 )
2016
19
Differential fMRI BOLD responses in amygdala in intermittent explosive disorder as a function of past Alcohol Use Disorder. ( 27693977 )
2016
20
Comorbid intermittent explosive disorder and posttraumatic stress disorder: Clinical correlates and relationship to suicidal behavior. ( 27624432 )
2016
21
Substance use disorders: Relationship with intermittent explosive disorder and with aggression, anger, and impulsivity. ( 27442963 )
2016
22
The cross-national epidemiology of DSM-IV intermittent explosive disorder. ( 27572872 )
2016
23
Defense styles in Intermittent Explosive Disorder. ( 27086223 )
2016
24
Development of a screening questionnaire for DSM-5 intermittent explosive disorder (IED-SQ). ( 28088746 )
2016
25
Prevalence of DSM-IV intermittent explosive disorder in Black adolescents: Findings from the National Survey of American Life, Adolescent Supplement. ( 27078052 )
2016
26
White Matter Integrity Reductions in Intermittent Explosive Disorder. ( 27206265 )
2016
27
Frontolimbic Morphometric Abnormalities in Intermittent Explosive Disorder and Aggression. ( 29560894 )
2016
28
Effects of Escitalopram Administration on Face Processing in Intermittent Explosive Disorder: An fMRI Study. ( 26105140 )
2015
29
Emotional intelligence and impulsive aggression in Intermittent Explosive Disorder. ( 25477263 )
2015
30
Emotion regulation deficits in intermittent explosive disorder. ( 27539871 )
2015
31
Inflammatory markers and chronic exposure to fluoxetine, divalproex, and placebo in intermittent explosive disorder. ( 26277033 )
2015
32
Verbal versus physical aggression in Intermittent Explosive Disorder. ( 25534757 )
2015
33
The coherence and correlates of intermittent explosive disorder amongst West Papuan refugees displaced to Papua New Guinea. ( 25754605 )
2015
34
The experience of aggressive outbursts in Intermittent Explosive Disorder. ( 25541537 )
2015
35
Doing Psychiatry Right: A Case of Severe Avoidant Personality Disorder with Obsessive-compulsive Personality Disorder, Obsessive Compulsive Disorder, Intermittent Explosive Disorder and Sexual Paraphilias. ( 25035563 )
2014
36
Elevated Plasma Oxidative Stress Markers in Individuals with Intermittent Explosive Disorder and Correlation with Aggression in Humans. ( 24582164 )
2014
37
Intermittent explosive disorder: associations with PTSD and other Axis I disorders in a US military veteran sample. ( 24907536 )
2014
38
Validity of the new A1 and A2 criteria for DSM-5 intermittent explosive disorder. ( 24321204 )
2014
39
Intermittent Explosive Disorder and aversive parental care. ( 25064384 )
2014
40
Emotion regulation deficits in intermittent explosive disorder. ( 25403171 )
2014
41
Common and distinct neural correlates of inhibitory dysregulation: stroop fMRI study of cocaine addiction and intermittent explosive disorder. ( 25106072 )
2014
42
Self-harm behavior among individuals with intermittent explosive disorder and personality disorders. ( 25300440 )
2014
43
History of childhood maltreatment in intermittent explosive disorder and suicidal behavior. ( 24935900 )
2014
44
Relationship between psychopathy, aggression, anger, impulsivity, and intermittent explosive disorder. ( 24760575 )
2014
45
Intermittent explosive disorder: a study in personalized psychopharmacotherapy. ( 24441311 )
2014
46
Elevated Plasma Inflammatory Markers in Individuals With Intermittent Explosive Disorder and Correlation With Aggression in Humans. ( 24352431 )
2013
47
Achieving convergence between a community-based measure of explosive anger and a clinical interview for intermittent explosive disorder in Timor-Leste. ( 23835102 )
2013
48
Intermittent explosive disorder amongst women in conflict affected Timor-Leste: associations with human rights trauma, ongoing violence, poverty, and injustice. ( 23950885 )
2013
49
Intermittent explosive disorder and DSM-5: a flawed conceptualization of pathological anger. ( 23719736 )
2013
50
Striatal activity in borderline personality disorder with comorbid intermittent explosive disorder: sex differences. ( 22464337 )
2012

Variations for Intermittent Explosive Disorder

Expression for Intermittent Explosive Disorder

Search GEO for disease gene expression data for Intermittent Explosive Disorder.

Pathways for Intermittent Explosive Disorder

Pathways related to Intermittent Explosive Disorder according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.13 ADRB1 CGA CHRNA7 GABRA2 HTR1A HTR7
2 11.82 ADRB1 CGA HTR7
3
Show member pathways
11.64 ADRB1 HTR1A HTR7
4 11.6 HTR1A HTR7 SLC6A4
5 11.41 CGA IL6 PRL
6 11.23 CHRFAM7A CHRNA7 HTR1A IL6 SLC6A4
7 11.06 ADRB1 CGA NPY
8 10.82 ADRB1 NPY
9 10.71 CRP IL6
10 10.58 HTR1A HTR7 SLC6A4

GO Terms for Intermittent Explosive Disorder

Cellular components related to Intermittent Explosive Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuron projection GO:0043005 9.56 CHRFAM7A CHRNA7 GABRA2 SLC6A4
2 integral component of plasma membrane GO:0005887 9.17 ADRB1 CHRFAM7A CHRNA7 GABRA2 HTR1A HTR7
3 acetylcholine-gated channel complex GO:0005892 9.16 CHRFAM7A CHRNA7
4 postsynapse GO:0098794 9.13 CHRFAM7A CHRNA7 GABRA2

Biological processes related to Intermittent Explosive Disorder according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.83 CRP CTSH IL6 SLC6A4
2 cell proliferation GO:0008283 9.8 GOLPH3 HTR1A NPY PRL
3 positive regulation of cell proliferation GO:0008284 9.73 CGA CHRNA7 CTSH HTR1A IL6 PRL
4 regulation of membrane potential GO:0042391 9.65 CHRFAM7A CHRNA7 GABRA2
5 circadian rhythm GO:0007623 9.63 HTR7 PRL SLC6A4
6 positive regulation of JAK-STAT cascade GO:0046427 9.54 IL6 PRL
7 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 9.54 HTR1A HTR7 NPY
8 synaptic transmission, cholinergic GO:0007271 9.51 CHRFAM7A CHRNA7
9 nervous system process GO:0050877 9.5 CHRFAM7A CHRNA7 GABRA2
10 negative regulation of organ growth GO:0046621 9.43 CGA SLC6A4
11 negative regulation of lipid storage GO:0010888 9.4 CRP IL6
12 vasoconstriction GO:0042310 9.33 HTR1A HTR7 SLC6A4
13 regulation of postsynaptic membrane potential GO:0060078 9.26 ADRB1 CHRFAM7A CHRNA7 GABRA2
14 chemical synaptic transmission GO:0007268 9.1 CHRFAM7A CHRNA7 GABRA2 HTR1A HTR7 NPY

Molecular functions related to Intermittent Explosive Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ion channel activity GO:0005216 9.54 CHRFAM7A CHRNA7 GABRA2
2 hormone activity GO:0005179 9.33 CGA NPY PRL
3 acetylcholine binding GO:0042166 9.32 CHRFAM7A CHRNA7
4 acetylcholine receptor activity GO:0015464 9.26 CHRFAM7A CHRNA7
5 serotonin binding GO:0051378 8.96 HTR1A SLC6A4
6 extracellular ligand-gated ion channel activity GO:0005230 8.8 CHRFAM7A CHRNA7 GABRA2

Sources for Intermittent Explosive Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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