MCID: INT025
MIFTS: 42

Intermittent Explosive Disorder

Categories: Mental diseases

Aliases & Classifications for Intermittent Explosive Disorder

MalaCards integrated aliases for Intermittent Explosive Disorder:

Name: Intermittent Explosive Disorder 12 15 73
Explosive Personality Disorder 12 73

Classifications:



External Ids:

Disease Ontology 12 DOID:12401
ICD10 33 F60.3 F63.81
ICD9CM 35 301.3 312.34
MeSH 44 D007174
NCIt 50 C94332

Summaries for Intermittent Explosive Disorder

Disease Ontology : 12 An impulse control disorder that involves the episodic inability to control violent impulses with a disproportionate degree of aggressiveness.

MalaCards based summary : Intermittent Explosive Disorder, also known as explosive personality disorder, is related to disease of mental health and obsessive-compulsive disorder. An important gene associated with Intermittent Explosive Disorder is SLC6A4 (Solute Carrier Family 6 Member 4), and among its related pathways/superpathways are Peptide ligand-binding receptors and G alpha (s) signalling events. The drugs Guanfacine and Naratriptan have been mentioned in the context of this disorder. Affiliated tissues include amygdala and brain, and related phenotypes are homeostasis/metabolism and nervous system

Wikipedia : 76 Intermittent explosive disorder (sometimes abbreviated as IED) is a behavioral disorder characterized by... more...

Related Diseases for Intermittent Explosive Disorder

Diseases related to Intermittent Explosive Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 73)
# Related Disease Score Top Affiliating Genes
1 disease of mental health 30.4 HTR1A HTR7 SLC6A4
2 obsessive-compulsive disorder 29.8 HTR1A PRL SLC6A4
3 bipolar disorder 29.2 CHRNA7 HTR1A PRL SLC6A4
4 major depressive disorder 28.3 HTR1A IL6 NPY PRL SLC6A4
5 pyromania 11.1
6 phobic disorder 10.7 HTR1A SLC6A4
7 dissociative amnesia 10.6 HTR1A SMUG1
8 atypical depressive disorder 10.6 HTR7 SLC6A4
9 ovarian squamous cell carcinoma 10.6 CRP SMUG1
10 aortitis 10.6 CRP SMUG1
11 premature ejaculation 10.5 HTR1A SLC6A4
12 cold agglutinin disease 10.5 CRP IL6
13 cryopyrin-associated periodic syndrome 10.5 CRP IL6
14 dysthymic disorder 10.5 HTR7 SLC6A4
15 cardiogenic shock 10.5 CRP IL6
16 microscopic colitis 10.5 IL6 SLC6A4
17 rumination disorder 10.5 HTR1A HTR7
18 acute cholangitis 10.5 CRP IL6
19 cartilage disease 10.5 CRP SMUG1
20 neutrophilia, hereditary 10.4 CRP IL6
21 uremic pruritus 10.4 CRP IL6
22 spinal disease 10.4 CRP IL6
23 castleman disease 10.4 CRP IL6
24 chronic pulmonary heart disease 10.4 HTR7 SLC6A4
25 periodic limb movement disorder 10.4 HTR1A SLC6A4
26 angina pectoris 10.3 CRP IL6
27 viral pneumonia 10.3 CRP IL6
28 motion sickness 10.3 HTR1A HTR7
29 psychosexual disorder 10.3 HTR1A HTR7 SLC6A4
30 chronic fatigue syndrome 10.3 HTR1A IL6 SLC6A4
31 kleptomania 10.3 HTR1A HTR7 SLC6A4
32 brunner syndrome 10.3 HTR1A HTR7 SLC6A4
33 mental depression 10.3 HTR1A HTR7 SLC6A4
34 cecal disease 10.2 CRP IL6
35 lactocele 10.2 PRL SMUG1
36 systolic heart failure 10.2 ADRB1 CRP IL6
37 relapsing polychondritis 10.2 CRP IL6
38 central nervous system vasculitis 10.2 CRP IL6 SMUG1
39 melancholia 10.1 CRP PRL
40 subacute thyroiditis 10.1 CRP IL6
41 anxiety 10.1 HTR1A NPY SLC6A4
42 temporal arteritis 10.1 CRP IL6 SMUG1
43 fibromyalgia 10.1 IL6 NPY SLC6A4
44 social phobia 10.1 HTR1A PRL SLC6A4
45 personality disorder 10.1
46 postpartum depression 10.1 HTR1A PRL SLC6A4
47 migraine without aura 10.1 HTR1A PRL SLC6A4
48 stereotypic movement disorder 10.0 NPY PRL
49 intussusception 10.0 CRP IL6
50 pulmonary aspergilloma 10.0 CRP SMUG1

Comorbidity relations with Intermittent Explosive Disorder via Phenotypic Disease Network (PDN):


Acute Cystitis Alzheimer Disease
Schizophreniform Disorder

Graphical network of the top 20 diseases related to Intermittent Explosive Disorder:



Diseases related to Intermittent Explosive Disorder

Symptoms & Phenotypes for Intermittent Explosive Disorder

MGI Mouse Phenotypes related to Intermittent Explosive Disorder:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.73 CRP GABRA2 HTR1A HTR7 IL6 NPY
2 nervous system MP:0003631 9.28 CHRNA7 GABRA2 HTR1A HTR7 IL6 NPY

Drugs & Therapeutics for Intermittent Explosive Disorder

Drugs for Intermittent Explosive Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 48)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Guanfacine Approved, Investigational Phase 4 29110-47-2 3519
2
Naratriptan Approved, Investigational Phase 4 143388-64-1, 121679-13-8 4440
3
Sumatriptan Approved, Investigational Phase 4 103628-46-2 5358
4 Adrenergic Agents Phase 4
5 Adrenergic Agonists Phase 4
6 Adrenergic alpha-2 Receptor Agonists Phase 4
7 Adrenergic alpha-Agonists Phase 4
8 Antihypertensive Agents Phase 4
9 Neurotransmitter Agents Phase 4,Phase 3,Phase 2
10 Serotonin Agents Phase 4,Phase 3,Phase 2
11 Vasoconstrictor Agents Phase 4,Phase 1,Phase 2
12 Serotonin 5-HT1 Receptor Agonists Phase 4
13
Serotonin Investigational, Nutraceutical Phase 4,Phase 3,Phase 2 50-67-9 5202
14
Dopamine Approved Phase 3 51-61-6, 62-31-7 681
15
Risperidone Approved, Investigational Phase 3 106266-06-2 5073
16
Carbidopa Approved Phase 3 28860-95-9 34359 38101
17
Levodopa Approved Phase 3 59-92-7 6047
18 Antipsychotic Agents Phase 3
19 Central Nervous System Depressants Phase 3,Not Applicable
20 Dopamine Agents Phase 3
21 Dopamine Antagonists Phase 3
22 Psychotropic Drugs Phase 3,Phase 2
23 Serotonin Antagonists Phase 3
24 Tranquilizing Agents Phase 3
25 Adjuvants, Immunologic Phase 3
26 Antiparkinson Agents Phase 3
27 Aromatic Amino Acid Decarboxylase Inhibitors Phase 3
28 Carbidopa, levodopa drug combination Phase 3
29 Dopamine agonists Phase 3
30
Fluoxetine Approved, Vet_approved Phase 2 54910-89-3 3386
31
Quinidine Approved, Investigational Phase 2 56-54-2 441074
32 Arginine Vasopressin Phase 1, Phase 2
33 Coagulants Phase 1, Phase 2
34 Hemostatics Phase 1, Phase 2
35 Hormones Phase 1, Phase 2
36 Natriuretic Agents Phase 1, Phase 2
37 SRX246 Phase 1, Phase 2
38 Vasopressins Phase 1, Phase 2
39 Antidepressive Agents Phase 2
40 Antidepressive Agents, Second-Generation Phase 2
41 Cytochrome P-450 CYP2D6 Inhibitors Phase 2
42 Cytochrome P-450 Enzyme Inhibitors Phase 2
43 Neurotransmitter Uptake Inhibitors Phase 2
44 Serotonin Uptake Inhibitors Phase 2
45 Quinidine gluconate Phase 2
46
Ethanol Approved Not Applicable 64-17-5 702
47 Anti-Infective Agents Not Applicable
48 Anti-Infective Agents, Local Not Applicable

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Intuniv vs Placebo in the Treatment of Childhood Intermittent Explosive Disorder Completed NCT02048241 Phase 4 Intuniv
2 Efficacy of a Triptan in the Treatment of Hostility and Aggression Among Convicts With a Psychiatric Treatment Order Terminated NCT00282165 Phase 4 naratriptan;placebo
3 Study to Determine Whether There Are Any Cognitive or Motor Effects From Taking the Medicine Risperidone. Completed NCT00399698 Phase 3 Risperdal
4 Safety/Efficacy Study of Levodopa-Carbidopa Intestinal Gel in Parkinson's Subjects Completed NCT00360568 Phase 3 Levodopa-carbidopa intestinal gel
5 Levodopa-Carbidopa Intestinal Gel Open-Label Study in Advanced Parkinson's Disease Completed NCT00335153 Phase 3 Levodopa-carbidopa intestinal gel
6 Safety, Tolerability and Activity of SRX246 in Adults With Intermittent Explosive Disorder Completed NCT02055638 Phase 1, Phase 2 SRX246;Placebo
7 Psychotherapy for Intermittent Explosive Disorder Completed NCT00667212 Phase 2
8 A Comparison of Fluoxetine and Divalproex for the Treatment of Intermittent Explosive Disorder Completed NCT00078754 Phase 2 Fluoxetine;Divalproex;Placebo
9 A Pilot Study Comparing the Efficacy of Group Versus Individual Anger Management in Subjects With IED Completed NCT00127400 Phase 2
10 Study to Assess the Efficacy, Safety, and Tolerability of AVP-786 for the Treatment of Intermittent Explosive Disorder Recruiting NCT03420222 Phase 2 AVP-786;Placebo
11 Alcohol Related Impairment and Reinforcement: Pre to Post Roux en Y Gastric Bypass Surgery Recruiting NCT02370732 Not Applicable

Search NIH Clinical Center for Intermittent Explosive Disorder

Genetic Tests for Intermittent Explosive Disorder

Anatomical Context for Intermittent Explosive Disorder

MalaCards organs/tissues related to Intermittent Explosive Disorder:

41
Amygdala, Brain

Publications for Intermittent Explosive Disorder

Articles related to Intermittent Explosive Disorder:

(show top 50) (show all 92)
# Title Authors Year
1
DSM-5 intermittent explosive disorder: Relationship with Disruptive Mood Dysregulation Disorder. ( 29753187 )
2018
2
Major depressive disorder and depressive symptoms in intermittent explosive disorder. ( 29455060 )
2018
3
Treatment of Intermittent Explosive Disorder With Carbamazepine. ( 29533363 )
2018
4
Prevalence and clinical correlates of intermittent explosive disorder in Turkish psychiatric outpatients. ( 29604524 )
2018
5
Cognitive-behavioral group therapy for intermittent explosive disorder: description and preliminary analysis. ( 29590263 )
2018
6
Genome-Wide DNA Methylation Changes Associated with Intermittent Explosive Disorder: A Gene-Based Functional Enrichment Analysis. ( 29106553 )
2018
7
Psychosocial impairment in DSM-5 intermittent explosive disorder. ( 29627702 )
2018
8
Intermittent explosive disorder and eating disorders: Analysis of national comorbidity and research samples. ( 28324677 )
2017
9
Intermittent Explosive Disorder and Substance Use Disorder: Analysis of the National Comorbidity Survey Replication Sample. ( 28252880 )
2017
10
A Wait-List Controlled Study of a Trauma-Focused Cognitive Behavioral Treatment for Intermittent Explosive Disorder in Timor-Leste. ( 28749158 )
2017
11
Negative urgency and reward/punishment sensitivity in intermittent explosive disorder. ( 27155024 )
2016
12
Social cognition in Intermittent Explosive Disorder and aggression. ( 27621104 )
2016
13
Amygdala hyperactivation to angry faces in intermittent explosive disorder. ( 27145325 )
2016
14
Single Case Study: Neuropsychological Functioning in a Patient Diagnosed with Intermittent Explosive Disorder Pre and Post Neurosurgery. ( 27161981 )
2016
15
Differential fMRI BOLD responses in amygdala in intermittent explosive disorder as a function of past Alcohol Use Disorder. ( 27693977 )
2016
16
Comorbid intermittent explosive disorder and posttraumatic stress disorder: Clinical correlates and relationship to suicidal behavior. ( 27624432 )
2016
17
Substance use disorders: Relationship with intermittent explosive disorder and with aggression, anger, and impulsivity. ( 27442963 )
2016
18
The cross-national epidemiology of DSM-IV intermittent explosive disorder. ( 27572872 )
2016
19
Defense styles in Intermittent Explosive Disorder. ( 27086223 )
2016
20
Development of a screening questionnaire for DSM-5 intermittent explosive disorder (IED-SQ). ( 28088746 )
2016
21
White Matter Integrity Reductions in Intermittent Explosive Disorder. ( 27206265 )
2016
22
Prevalence of DSM-IV Intermittent Explosive Disorder in Black Adolescents: Findings From the National Survey of American Life, Adolescent Supplement. ( 27078052 )
2016
23
Effects of Escitalopram Administration on Face Processing in Intermittent Explosive Disorder: An fMRI Study. ( 26105140 )
2015
24
Emotional intelligence and impulsive aggression in Intermittent Explosive Disorder. ( 25477263 )
2015
25
Emotion regulation deficits in intermittent explosive disorder. ( 27539871 )
2015
26
Inflammatory markers and chronic exposure to fluoxetine, divalproex, and placebo in intermittent explosive disorder. ( 26277033 )
2015
27
Verbal versus physical aggression in Intermittent Explosive Disorder. ( 25534757 )
2015
28
The coherence and correlates of intermittent explosive disorder amongst West Papuan refugees displaced to Papua New Guinea. ( 25754605 )
2015
29
The experience of aggressive outbursts in Intermittent Explosive Disorder. ( 25541537 )
2015
30
Doing Psychiatry Right: A Case of Severe Avoidant Personality Disorder with Obsessive-compulsive Personality Disorder, Obsessive Compulsive Disorder, Intermittent Explosive Disorder and Sexual Paraphilias. ( 25035563 )
2014
31
Elevated Plasma Oxidative Stress Markers in Individuals with Intermittent Explosive Disorder and Correlation with Aggression in Humans. ( 24582164 )
2014
32
Intermittent explosive disorder: associations with PTSD and other Axis I disorders in a US military veteran sample. ( 24907536 )
2014
33
Validity of the new A1 and A2 criteria for DSM-5 intermittent explosive disorder. ( 24321204 )
2014
34
Intermittent Explosive Disorder and aversive parental care. ( 25064384 )
2014
35
Emotion regulation deficits in intermittent explosive disorder. ( 25403171 )
2014
36
Common and distinct neural correlates of inhibitory dysregulation: stroop fMRI study of cocaine addiction and intermittent explosive disorder. ( 25106072 )
2014
37
Self-harm behavior among individuals with intermittent explosive disorder and personality disorders. ( 25300440 )
2014
38
History of childhood maltreatment in intermittent explosive disorder and suicidal behavior. ( 24935900 )
2014
39
Relationship between psychopathy, aggression, anger, impulsivity, and intermittent explosive disorder. ( 24760575 )
2014
40
Intermittent explosive disorder: a study in personalized psychopharmacotherapy. ( 24441311 )
2014
41
Elevated Plasma Inflammatory Markers in Individuals With Intermittent Explosive Disorder and Correlation With Aggression in Humans. ( 24352431 )
2013
42
Achieving convergence between a community-based measure of explosive anger and a clinical interview for intermittent explosive disorder in Timor-Leste. ( 23835102 )
2013
43
Intermittent explosive disorder amongst women in conflict affected Timor-Leste: associations with human rights trauma, ongoing violence, poverty, and injustice. ( 23950885 )
2013
44
Intermittent explosive disorder and DSM-5: a flawed conceptualization of pathological anger. ( 23719736 )
2013
45
Striatal activity in borderline personality disorder with comorbid intermittent explosive disorder: sex differences. ( 22464337 )
2012
46
Intermittent explosive disorder in the National Comorbidity Survey Replication Adolescent Supplement. ( 22752056 )
2012
47
Intermittent explosive disorder as a disorder of impulsive aggression for DSM-5. ( 22535310 )
2012
48
The prevalence and correlates of intermittent explosive disorder in Iraq. ( 22443168 )
2012
49
The relationship between childhood exposure to trauma and intermittent explosive disorder. ( 22464047 )
2012
50
Intermittent explosive disorder: development of integrated research criteria for Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition. ( 21295216 )
2011

Variations for Intermittent Explosive Disorder

Expression for Intermittent Explosive Disorder

Search GEO for disease gene expression data for Intermittent Explosive Disorder.

Pathways for Intermittent Explosive Disorder

Pathways related to Intermittent Explosive Disorder according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.13 ADRB1 CGA CHRNA7 GABRA2 HTR1A HTR7
2 11.82 ADRB1 CGA HTR7
3
Show member pathways
11.64 ADRB1 HTR1A HTR7
4 11.6 HTR1A HTR7 SLC6A4
5 11.41 CGA IL6 PRL
6 11.23 CHRFAM7A CHRNA7 HTR1A IL6 SLC6A4
7 11.06 ADRB1 CGA NPY
8 10.82 ADRB1 NPY
9 10.71 CRP IL6
10 10.58 HTR1A HTR7 SLC6A4

GO Terms for Intermittent Explosive Disorder

Cellular components related to Intermittent Explosive Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuron projection GO:0043005 9.46 CHRFAM7A CHRNA7 GABRA2 SLC6A4
2 integral component of plasma membrane GO:0005887 9.17 ADRB1 CHRFAM7A CHRNA7 GABRA2 HTR1A HTR7
3 acetylcholine-gated channel complex GO:0005892 8.96 CHRFAM7A CHRNA7

Biological processes related to Intermittent Explosive Disorder according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.8 CRP CTSH IL6 SLC6A4
2 cell proliferation GO:0008283 9.78 GOLPH3 HTR1A NPY PRL
3 regulation of membrane potential GO:0042391 9.63 CHRFAM7A CHRNA7 GABRA2
4 positive regulation of cell proliferation GO:0008284 9.63 CGA CHRNA7 CTSH HTR1A IL6 PRL
5 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 9.54 HTR1A HTR7 NPY
6 positive regulation of JAK-STAT cascade GO:0046427 9.51 IL6 PRL
7 nervous system process GO:0050877 9.5 CHRFAM7A CHRNA7 GABRA2
8 negative regulation of organ growth GO:0046621 9.43 CGA SLC6A4
9 negative regulation of lipid storage GO:0010888 9.4 CRP IL6
10 adenylate cyclase-inhibiting serotonin receptor signaling pathway GO:0007198 9.26 HTR1A HTR7
11 vasoconstriction GO:0042310 9.13 HTR1A HTR7 SLC6A4
12 chemical synaptic transmission GO:0007268 9.1 CHRFAM7A CHRNA7 GABRA2 HTR1A HTR7 NPY

Molecular functions related to Intermittent Explosive Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ion channel activity GO:0005216 9.54 CHRFAM7A CHRNA7 GABRA2
2 neurotransmitter receptor activity GO:0030594 9.43 HTR1A HTR7
3 G-protein coupled serotonin receptor activity GO:0004993 9.4 HTR1A HTR7
4 hormone activity GO:0005179 9.33 CGA NPY PRL
5 acetylcholine binding GO:0042166 9.32 CHRFAM7A CHRNA7
6 acetylcholine receptor activity GO:0015464 9.26 CHRFAM7A CHRNA7
7 serotonin binding GO:0051378 8.96 HTR1A HTR7
8 extracellular ligand-gated ion channel activity GO:0005230 8.8 CHRFAM7A CHRNA7 GABRA2

Sources for Intermittent Explosive Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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