Intermittent Explosive Disorder disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: INT025 MIFTS: 42	Intermittent Explosive Disorder Categories: Mental diseases
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Aliases & Classifications for Intermittent Explosive Disorder

MalaCards integrated aliases for Intermittent Explosive Disorder:

Name: Intermittent Explosive Disorder ¹² ¹⁵ ⁷³

Explosive Personality Disorder ¹² ⁷³

Classifications:

MalaCards categories:
Anatomical: Mental diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Mental and behavioural disorders

Disorders of adult personality and behaviour

Specific personality disorders

Emotionally unstable personality disorder

External Ids:

Disease Ontology ¹² DOID:12401

ICD10 ³³ F60.3 F63.81

ICD9CM ³⁵ 301.3 312.34

MeSH ⁴⁴ D007174

NCIt ⁵⁰ C94332

SNOMED-CT ⁶⁸ 191759005 192096007 192488005 more

UMLS ⁷³ C0021776 C0152183

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Summaries for Intermittent Explosive Disorder

Disease Ontology : ¹² An impulse control disorder that involves the episodic inability to control violent impulses with a disproportionate degree of aggressiveness.

MalaCards based summary : Intermittent Explosive Disorder, also known as explosive personality disorder, is related to disease of mental health and obsessive-compulsive disorder. An important gene associated with Intermittent Explosive Disorder is SLC6A4 (Solute Carrier Family 6 Member 4), and among its related pathways/superpathways are Peptide ligand-binding receptors and G alpha (s) signalling events. The drugs Guanfacine and Naratriptan have been mentioned in the context of this disorder. Affiliated tissues include amygdala and brain, and related phenotypes are homeostasis/metabolism and nervous system

Wikipedia : ⁷⁶ Intermittent explosive disorder (sometimes abbreviated as IED) is a behavioral disorder characterized by... more...

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Related Diseases for Intermittent Explosive Disorder

Diseases related to Intermittent Explosive Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 73)

#	Related Disease	Score	Top Affiliating Genes
1	disease of mental health	30.4	HTR1A HTR7 SLC6A4
2	obsessive-compulsive disorder	29.8	HTR1A PRL SLC6A4
3	bipolar disorder	29.2	CHRNA7 HTR1A PRL SLC6A4
4	major depressive disorder	28.3	HTR1A IL6 NPY PRL SLC6A4
5	pyromania	11.1
6	phobic disorder	10.7	HTR1A SLC6A4
7	dissociative amnesia	10.6	HTR1A SMUG1
8	atypical depressive disorder	10.6	HTR7 SLC6A4
9	ovarian squamous cell carcinoma	10.6	CRP SMUG1
10	aortitis	10.6	CRP SMUG1
11	premature ejaculation	10.5	HTR1A SLC6A4
12	cold agglutinin disease	10.5	CRP IL6
13	cryopyrin-associated periodic syndrome	10.5	CRP IL6
14	dysthymic disorder	10.5	HTR7 SLC6A4
15	cardiogenic shock	10.5	CRP IL6
16	microscopic colitis	10.5	IL6 SLC6A4
17	rumination disorder	10.5	HTR1A HTR7
18	acute cholangitis	10.5	CRP IL6
19	cartilage disease	10.5	CRP SMUG1
20	neutrophilia, hereditary	10.4	CRP IL6
21	uremic pruritus	10.4	CRP IL6
22	spinal disease	10.4	CRP IL6
23	castleman disease	10.4	CRP IL6
24	chronic pulmonary heart disease	10.4	HTR7 SLC6A4
25	periodic limb movement disorder	10.4	HTR1A SLC6A4
26	angina pectoris	10.3	CRP IL6
27	viral pneumonia	10.3	CRP IL6
28	motion sickness	10.3	HTR1A HTR7
29	psychosexual disorder	10.3	HTR1A HTR7 SLC6A4
30	chronic fatigue syndrome	10.3	HTR1A IL6 SLC6A4
31	kleptomania	10.3	HTR1A HTR7 SLC6A4
32	brunner syndrome	10.3	HTR1A HTR7 SLC6A4
33	mental depression	10.3	HTR1A HTR7 SLC6A4
34	cecal disease	10.2	CRP IL6
35	lactocele	10.2	PRL SMUG1
36	systolic heart failure	10.2	ADRB1 CRP IL6
37	relapsing polychondritis	10.2	CRP IL6
38	central nervous system vasculitis	10.2	CRP IL6 SMUG1
39	melancholia	10.1	CRP PRL
40	subacute thyroiditis	10.1	CRP IL6
41	anxiety	10.1	HTR1A NPY SLC6A4
42	temporal arteritis	10.1	CRP IL6 SMUG1
43	fibromyalgia	10.1	IL6 NPY SLC6A4
44	social phobia	10.1	HTR1A PRL SLC6A4
45	personality disorder	10.1
46	postpartum depression	10.1	HTR1A PRL SLC6A4
47	migraine without aura	10.1	HTR1A PRL SLC6A4
48	stereotypic movement disorder	10.0	NPY PRL
49	intussusception	10.0	CRP IL6
50	pulmonary aspergilloma	10.0	CRP SMUG1

Comorbidity relations with Intermittent Explosive Disorder via Phenotypic Disease Network (PDN):

Acute Cystitis	Alzheimer Disease
Schizophreniform Disorder

Graphical network of the top 20 diseases related to Intermittent Explosive Disorder:

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Symptoms & Phenotypes for Intermittent Explosive Disorder

MGI Mouse Phenotypes related to Intermittent Explosive Disorder:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	9.73	CRP GABRA2 HTR1A HTR7 IL6 NPY
2	nervous system	MP:0003631	9.28	CHRNA7 GABRA2 HTR1A HTR7 IL6 NPY

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Drugs & Therapeutics for Intermittent Explosive Disorder

Drugs for Intermittent Explosive Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 48)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Guanfacine

Approved, Investigational

Phase 4

29110-47-2

3519

Naratriptan

Approved, Investigational

Phase 4

143388-64-1, 121679-13-8

4440

Sumatriptan

Approved, Investigational

Phase 4

103628-46-2

5358

Adrenergic Agents

Phase 4

Adrenergic Agonists

Phase 4

Adrenergic alpha-2 Receptor Agonists

Phase 4

Adrenergic alpha-Agonists

Phase 4

Antihypertensive Agents

Phase 4

Neurotransmitter Agents

Phase 4,Phase 3,Phase 2

Serotonin Agents

Phase 4,Phase 3,Phase 2

Vasoconstrictor Agents

Phase 4,Phase 1,Phase 2

Serotonin 5-HT1 Receptor Agonists

Phase 4

Serotonin

Investigational, Nutraceutical

Phase 4,Phase 3,Phase 2

50-67-9

5202

Dopamine

Approved

Phase 3

51-61-6, 62-31-7

681

Risperidone

Approved, Investigational

Phase 3

106266-06-2

5073

Carbidopa

Approved

Phase 3

28860-95-9

34359 38101

Levodopa

Approved

Phase 3

59-92-7

6047

Antipsychotic Agents

Phase 3

Central Nervous System Depressants

Phase 3,Not Applicable

Dopamine Agents

Phase 3

Dopamine Antagonists

Phase 3

Psychotropic Drugs

Phase 3,Phase 2

Serotonin Antagonists

Phase 3

Tranquilizing Agents

Phase 3

Adjuvants, Immunologic

Phase 3

Antiparkinson Agents

Phase 3

Aromatic Amino Acid Decarboxylase Inhibitors

Phase 3

Carbidopa, levodopa drug combination

Phase 3

Dopamine agonists

Phase 3

Fluoxetine

Approved, Vet_approved

Phase 2

54910-89-3

3386

Quinidine

Approved, Investigational

Phase 2

56-54-2

441074

Arginine Vasopressin

Phase 1, Phase 2

Coagulants

Phase 1, Phase 2

Hemostatics

Phase 1, Phase 2

Hormones

Phase 1, Phase 2

Natriuretic Agents

Phase 1, Phase 2

SRX246

Phase 1, Phase 2

Vasopressins

Phase 1, Phase 2

Antidepressive Agents

Phase 2

Antidepressive Agents, Second-Generation

Phase 2

Cytochrome P-450 CYP2D6 Inhibitors

Phase 2

Cytochrome P-450 Enzyme Inhibitors

Phase 2

Neurotransmitter Uptake Inhibitors

Phase 2

Serotonin Uptake Inhibitors

Phase 2

Quinidine gluconate

Phase 2

Ethanol

Approved

Not Applicable

64-17-5

702

Anti-Infective Agents

Not Applicable

Anti-Infective Agents, Local

Not Applicable

Interventional clinical trials:

(show all 11)

#	Name	Status	NCT ID	Phase	Drugs
1	Intuniv vs Placebo in the Treatment of Childhood Intermittent Explosive Disorder	Completed	NCT02048241	Phase 4	Intuniv
2	Efficacy of a Triptan in the Treatment of Hostility and Aggression Among Convicts With a Psychiatric Treatment Order	Terminated	NCT00282165	Phase 4	naratriptan;placebo
3	Study to Determine Whether There Are Any Cognitive or Motor Effects From Taking the Medicine Risperidone.	Completed	NCT00399698	Phase 3	Risperdal
4	Safety/Efficacy Study of Levodopa-Carbidopa Intestinal Gel in Parkinson's Subjects	Completed	NCT00360568	Phase 3	Levodopa-carbidopa intestinal gel
5	Levodopa-Carbidopa Intestinal Gel Open-Label Study in Advanced Parkinson's Disease	Completed	NCT00335153	Phase 3	Levodopa-carbidopa intestinal gel
6	Safety, Tolerability and Activity of SRX246 in Adults With Intermittent Explosive Disorder	Completed	NCT02055638	Phase 1, Phase 2	SRX246;Placebo
7	Psychotherapy for Intermittent Explosive Disorder	Completed	NCT00667212	Phase 2
8	A Comparison of Fluoxetine and Divalproex for the Treatment of Intermittent Explosive Disorder	Completed	NCT00078754	Phase 2	Fluoxetine;Divalproex;Placebo
9	A Pilot Study Comparing the Efficacy of Group Versus Individual Anger Management in Subjects With IED	Completed	NCT00127400	Phase 2
10	Study to Assess the Efficacy, Safety, and Tolerability of AVP-786 for the Treatment of Intermittent Explosive Disorder	Recruiting	NCT03420222	Phase 2	AVP-786;Placebo
11	Alcohol Related Impairment and Reinforcement: Pre to Post Roux en Y Gastric Bypass Surgery	Recruiting	NCT02370732	Not Applicable

Search NIH Clinical Center for Intermittent Explosive Disorder

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Genetic Tests for Intermittent Explosive Disorder

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Anatomical Context for Intermittent Explosive Disorder

MalaCards organs/tissues related to Intermittent Explosive Disorder:

⁴¹

Amygdala, Brain

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Publications for Intermittent Explosive Disorder

Articles related to Intermittent Explosive Disorder:

(show top 50) (show all 92)

#	Title	Authors	Year
1	DSM-5 intermittent explosive disorder: Relationship with Disruptive Mood Dysregulation Disorder. ( 29753187 )	Coccaro E.F.	2018
2	Major depressive disorder and depressive symptoms in intermittent explosive disorder. ( 29455060 )	Medeiros G.C....Tavares H.	2018
3	Treatment of Intermittent Explosive Disorder With Carbamazepine. ( 29533363 )	Coskun F....Akca O.F.	2018
4	Prevalence and clinical correlates of intermittent explosive disorder in Turkish psychiatric outpatients. ( 29604524 )	Gelegen V....Tamam L.	2018
5	Cognitive-behavioral group therapy for intermittent explosive disorder: description and preliminary analysis. ( 29590263 )	Costa A.M....Seger L.	2018
6	Genome-Wide DNA Methylation Changes Associated with Intermittent Explosive Disorder: A Gene-Based Functional Enrichment Analysis. ( 29106553 )	Montalvo-Ortiz J.L....Coccaro E.F.	2018
7	Psychosocial impairment in DSM-5 intermittent explosive disorder. ( 29627702 )	Rynar L....Coccaro E.F.	2018
8	Intermittent explosive disorder and eating disorders: Analysis of national comorbidity and research samples. ( 28324677 )	Jennings K.M....Coccaro E.F.	2017
9	Intermittent Explosive Disorder and Substance Use Disorder: Analysis of the National Comorbidity Survey Replication Sample. ( 28252880 )	Coccaro E.F....Lee R.	2017
10	A Wait-List Controlled Study of a Trauma-Focused Cognitive Behavioral Treatment for Intermittent Explosive Disorder in Timor-Leste. ( 28749158 )	Hewage K....Silove D.	2017
11	Negative urgency and reward/punishment sensitivity in intermittent explosive disorder. ( 27155024 )	Puhalla A.A....McCloskey M.S.	2016
12	Social cognition in Intermittent Explosive Disorder and aggression. ( 27621104 )	Coccaro E.F....Lee R.J.	2016
13	Amygdala hyperactivation to angry faces in intermittent explosive disorder. ( 27145325 )	McCloskey M.S....Coccaro E.F.	2016
14	Single Case Study: Neuropsychological Functioning in a Patient Diagnosed with Intermittent Explosive Disorder Pre and Post Neurosurgery. ( 27161981 )	Alvarez-Alonso M.J....Jurado-Barba R.	2016
15	Differential fMRI BOLD responses in amygdala in intermittent explosive disorder as a function of past Alcohol Use Disorder. ( 27693977 )	Coccaro E.F....Phan K.L.	2016
16	Comorbid intermittent explosive disorder and posttraumatic stress disorder: Clinical correlates and relationship to suicidal behavior. ( 27624432 )	Fanning J.R....Coccaro E.F.	2016
17	Substance use disorders: Relationship with intermittent explosive disorder and with aggression, anger, and impulsivity. ( 27442963 )	Coccaro E.F....Lee R.	2016
18	The cross-national epidemiology of DSM-IV intermittent explosive disorder. ( 27572872 )	Scott K.M....Kessler R.C.	2016
19	Defense styles in Intermittent Explosive Disorder. ( 27086223 )	Puhalla A.A....Coccaro E.F.	2016
20	Development of a screening questionnaire for DSM-5 intermittent explosive disorder (IED-SQ). ( 28088746 )	Coccaro E.F....McCloskey M.S.	2016
21	White Matter Integrity Reductions in Intermittent Explosive Disorder. ( 27206265 )	Lee R....Coccaro E.F.	2016
22	Prevalence of DSM-IV Intermittent Explosive Disorder in Black Adolescents: Findings From the National Survey of American Life, Adolescent Supplement. ( 27078052 )	Oliver D.G....Jackson J.S.	2016
23	Effects of Escitalopram Administration on Face Processing in Intermittent Explosive Disorder: An fMRI Study. ( 26105140 )	Cremers H....Coccaro E.	2015
24	Emotional intelligence and impulsive aggression in Intermittent Explosive Disorder. ( 25477263 )	Coccaro E.F....Lee R.	2015
25	Emotion regulation deficits in intermittent explosive disorder. ( 27539871 )	Fettich K.C....Coccaro E.F.	2015
26	Inflammatory markers and chronic exposure to fluoxetine, divalproex, and placebo in intermittent explosive disorder. ( 26277033 )	Coccaro E.F....Irwin M.R.	2015
27	Verbal versus physical aggression in Intermittent Explosive Disorder. ( 25534757 )	Look A.E....Coccaro E.F.	2015
28	The coherence and correlates of intermittent explosive disorder amongst West Papuan refugees displaced to Papua New Guinea. ( 25754605 )	Tay A.K....Silove D.	2015
29	The experience of aggressive outbursts in Intermittent Explosive Disorder. ( 25541537 )	Kulper D.A....Coccaro E.F.	2015
30	Doing Psychiatry Right: A Case of Severe Avoidant Personality Disorder with Obsessive-compulsive Personality Disorder, Obsessive Compulsive Disorder, Intermittent Explosive Disorder and Sexual Paraphilias. ( 25035563 )	Hebbar S.	2014
31	Elevated Plasma Oxidative Stress Markers in Individuals with Intermittent Explosive Disorder and Correlation with Aggression in Humans. ( 24582164 )	Coccaro E.F....Gozal D.	2014
32	Intermittent explosive disorder: associations with PTSD and other Axis I disorders in a US military veteran sample. ( 24907536 )	Reardon A.F....Miller M.W.	2014
33	Validity of the new A1 and A2 criteria for DSM-5 intermittent explosive disorder. ( 24321204 )	Coccaro E.F....McCloskey M.S.	2014
34	Intermittent Explosive Disorder and aversive parental care. ( 25064384 )	Lee R....Coccaro E.F.	2014
35	Emotion regulation deficits in intermittent explosive disorder. ( 25403171 )	Fettich K.C....Coccaro E.F.	2014
36	Common and distinct neural correlates of inhibitory dysregulation: stroop fMRI study of cocaine addiction and intermittent explosive disorder. ( 25106072 )	Moeller S.J....Alia-Klein N.	2014
37	Self-harm behavior among individuals with intermittent explosive disorder and personality disorders. ( 25300440 )	Jenkins A.L....Coccaro E.F.	2014
38	History of childhood maltreatment in intermittent explosive disorder and suicidal behavior. ( 24935900 )	Fanning J.R....Coccaro E.F.	2014
39	Relationship between psychopathy, aggression, anger, impulsivity, and intermittent explosive disorder. ( 24760575 )	Coccaro E.F....McCloskey M.S.	2014
40	Intermittent explosive disorder: a study in personalized psychopharmacotherapy. ( 24441311 )	Leahy L.G.	2014
41	Elevated Plasma Inflammatory Markers in Individuals With Intermittent Explosive Disorder and Correlation With Aggression in Humans. ( 24352431 )	Coccaro E.F....Coussons-Read M.	2013
42	Achieving convergence between a community-based measure of explosive anger and a clinical interview for intermittent explosive disorder in Timor-Leste. ( 23835102 )	Liddell B.J....Steel Z.	2013
43	Intermittent explosive disorder amongst women in conflict affected Timor-Leste: associations with human rights trauma, ongoing violence, poverty, and injustice. ( 23950885 )	Rees S....Steel Z.	2013
44	Intermittent explosive disorder and DSM-5: a flawed conceptualization of pathological anger. ( 23719736 )	Anand S.	2013
45	Striatal activity in borderline personality disorder with comorbid intermittent explosive disorder: sex differences. ( 22464337 )	Perez-Rodriguez M.M....New A.S.	2012
46	Intermittent explosive disorder in the National Comorbidity Survey Replication Adolescent Supplement. ( 22752056 )	McLaughlin K.A....Kessler R.C.	2012
47	Intermittent explosive disorder as a disorder of impulsive aggression for DSM-5. ( 22535310 )	Coccaro E.F.	2012
48	The prevalence and correlates of intermittent explosive disorder in Iraq. ( 22443168 )	Al-Hamzawi A....McLaughlin K.A.	2012
49	The relationship between childhood exposure to trauma and intermittent explosive disorder. ( 22464047 )	Nickerson A....Hofmann S.G.	2012
50	Intermittent explosive disorder: development of integrated research criteria for Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition. ( 21295216 )	Coccaro E.F.	2011

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Genes for Intermittent Explosive Disorder

Genes related to Intermittent Explosive Disorder (0 elite genes):

(show all 16)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	SLC6A4	Solute Carrier Family 6 Member 4	Protein Coding	22.04	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
2	CGA	Glycoprotein Hormones, Alpha Polypeptide	Protein Coding	17.01	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
3	RUVBL1	RuvB Like AAA ATPase 1	Protein Coding	15.68	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
4	CTSH	Cathepsin H	Protein Coding	15.14	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
5	CHRFAM7A	CHRNA7 (Exons 5-10) And FAM7A (Exons A-E) Fusion	Protein Coding	15.03	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
6	CHRNA7	Cholinergic Receptor Nicotinic Alpha 7 Subunit	Protein Coding	15.02	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
7	ADRB1	Adrenoceptor Beta 1	Protein Coding	14.6	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
8	HTR1A	5-Hydroxytryptamine Receptor 1A	Protein Coding	14.03	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
9	SMUG1	Single-Strand-Selective Monofunctional Uracil-DNA Glycosylase 1	Protein Coding	14	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
10	CRP	C-Reactive Protein	Protein Coding	13.59	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
11	IL6	Interleukin 6	Protein Coding	13.54	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
12	HTR7	5-Hydroxytryptamine Receptor 7	Protein Coding	13.52	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
13	NPY	Neuropeptide Y	Protein Coding	13.49	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
14	PRL	Prolactin	Protein Coding	13.07	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
15	GABRA2	Gamma-Aminobutyric Acid Type A Receptor Alpha2 Subunit	Protein Coding	5.66	DISEASES inferred ¹⁵
16	GOLPH3	Golgi Phosphoprotein 3	Protein Coding	4.07	DISEASES inferred ¹⁵

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Variations for Intermittent Explosive Disorder

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Expression for Intermittent Explosive Disorder

Search GEO for disease gene expression data for Intermittent Explosive Disorder.

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Pathways for Intermittent Explosive Disorder

Pathways related to Intermittent Explosive Disorder according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Peptide ligand-binding receptors ⁶⁶ Show member pathways Class A/1 (Rhodopsin-like receptors) ⁶⁶ Defective AVP causes neurohypophyseal diabetes insipidus (NDI) ⁶⁶ Formyl peptide receptors bind formyl peptides and many other ligands ⁶⁶ G alpha (i) signalling events ⁶⁶ GPCR ligand binding ⁶⁶ GPCRs, Class A Rhodopsin-like ¹ Neuroactive ligand-receptor interaction ³⁷ Orexin and neuropeptides FF and QRFP bind to their respective receptors ⁶⁶ Peptide GPCRs ¹ Tachykinin receptors bind tachykinins ⁶⁶ Vasopressin-like receptors ⁶⁶	13.13	ADRB1 CGA CHRNA7 GABRA2 HTR1A HTR7
2	G alpha (s) signalling events ⁶⁶	11.82	ADRB1 CGA HTR7
3	Monoamine GPCRs ¹ Show member pathways Adrenaline signalling through Alpha-2 adrenergic receptor ⁶⁶ Adrenoceptors ⁶⁶ Amine ligand-binding receptors ⁶⁶ Dopamine receptors ⁶⁶ Histamine receptors ⁶⁶ Muscarinic acetylcholine receptors ⁶⁶ Serotonin receptors ⁶⁶	11.64	ADRB1 HTR1A HTR7
4	Serotonergic synapse ³⁷	11.6	HTR1A HTR7 SLC6A4
5	Glucocorticoid receptor regulatory network ¹	11.41	CGA IL6 PRL
6	Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways ¹	11.23	CHRFAM7A CHRNA7 HTR1A IL6 SLC6A4
7	Regulation of lipolysis in adipocytes ³⁷	11.06	ADRB1 CGA NPY
8	Sympathetic Nerve Pathway (Neuroeffector Junction) ⁶¹	10.82	ADRB1 NPY
9	Overview of nanoparticle effects ¹	10.71	CRP IL6
10	Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics ⁶¹	10.58	HTR1A HTR7 SLC6A4

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GO Terms for Intermittent Explosive Disorder

Cellular components related to Intermittent Explosive Disorder according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	neuron projection	GO:0043005	9.46	CHRFAM7A CHRNA7 GABRA2 SLC6A4
2	integral component of plasma membrane	GO:0005887	9.17	ADRB1 CHRFAM7A CHRNA7 GABRA2 HTR1A HTR7
3	acetylcholine-gated channel complex	GO:0005892	8.96	CHRFAM7A CHRNA7

Biological processes related to Intermittent Explosive Disorder according to GeneCards Suite gene sharing:

(show all 12)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of gene expression	GO:0010628	9.8	CRP CTSH IL6 SLC6A4
2	cell proliferation	GO:0008283	9.78	GOLPH3 HTR1A NPY PRL
3	regulation of membrane potential	GO:0042391	9.63	CHRFAM7A CHRNA7 GABRA2
4	positive regulation of cell proliferation	GO:0008284	9.63	CGA CHRNA7 CTSH HTR1A IL6 PRL
5	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	GO:0007187	9.54	HTR1A HTR7 NPY
6	positive regulation of JAK-STAT cascade	GO:0046427	9.51	IL6 PRL
7	nervous system process	GO:0050877	9.5	CHRFAM7A CHRNA7 GABRA2
8	negative regulation of organ growth	GO:0046621	9.43	CGA SLC6A4
9	negative regulation of lipid storage	GO:0010888	9.4	CRP IL6
10	adenylate cyclase-inhibiting serotonin receptor signaling pathway	GO:0007198	9.26	HTR1A HTR7
11	vasoconstriction	GO:0042310	9.13	HTR1A HTR7 SLC6A4
12	chemical synaptic transmission	GO:0007268	9.1	CHRFAM7A CHRNA7 GABRA2 HTR1A HTR7 NPY

Molecular functions related to Intermittent Explosive Disorder according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	ion channel activity	GO:0005216	9.54	CHRFAM7A CHRNA7 GABRA2
2	neurotransmitter receptor activity	GO:0030594	9.43	HTR1A HTR7
3	G-protein coupled serotonin receptor activity	GO:0004993	9.4	HTR1A HTR7
4	hormone activity	GO:0005179	9.33	CGA NPY PRL
5	acetylcholine binding	GO:0042166	9.32	CHRFAM7A CHRNA7
6	acetylcholine receptor activity	GO:0015464	9.26	CHRFAM7A CHRNA7
7	serotonin binding	GO:0051378	8.96	HTR1A HTR7
8	extracellular ligand-gated ion channel activity	GO:0005230	8.8	CHRFAM7A CHRNA7 GABRA2

Sources

Sources for Intermittent Explosive Disorder

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia