MCID: INT025
MIFTS: 39

Intermittent Explosive Disorder

Categories: Mental diseases

Aliases & Classifications for Intermittent Explosive Disorder

MalaCards integrated aliases for Intermittent Explosive Disorder:

Name: Intermittent Explosive Disorder 12 15 74
Explosive Personality Disorder 12 74

Classifications:



External Ids:

Disease Ontology 12 DOID:12401
ICD9CM 36 301.3 312.34
MeSH 45 D007174
NCIt 51 C94332
SNOMED-CT 69 40987004
ICD10 34 F60.3 F63.81

Summaries for Intermittent Explosive Disorder

Disease Ontology : 12 An impulse control disorder that involves the episodic inability to control violent impulses with a disproportionate degree of aggressiveness.

MalaCards based summary : Intermittent Explosive Disorder, also known as explosive personality disorder, is related to personality disorder and anxiety. An important gene associated with Intermittent Explosive Disorder is SLC6A4 (Solute Carrier Family 6 Member 4), and among its related pathways/superpathways are Peptide ligand-binding receptors and Glucocorticoid receptor regulatory network. The drugs Guanfacine and Naratriptan have been mentioned in the context of this disorder. Affiliated tissues include amygdala and brain, and related phenotype is homeostasis/metabolism.

Wikipedia : 77 Intermittent explosive disorder (sometimes abbreviated as IED) is a behavioral disorder characterized by... more...

Related Diseases for Intermittent Explosive Disorder

Diseases related to Intermittent Explosive Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 75)
# Related Disease Score Top Affiliating Genes
1 personality disorder 30.5 HTR1A PRL SLC6A4
2 anxiety 30.1 HTR1A NPY SLC6A4
3 disease of mental health 30.1 HTR1A IL6 SLC6A4
4 obsessive-compulsive disorder 29.9 HTR1A PRL SLC6A4
5 major depressive disorder 29.2 HTR1A IL6 NPY PRL SLC6A4
6 pyromania 11.3
7 psychosexual disorder 10.4 HTR1A SLC6A4
8 phobic disorder 10.3 HTR1A SLC6A4
9 kleptomania 10.3 HTR1A SLC6A4
10 periodic limb movement disorder 10.3 HTR1A SLC6A4
11 dissociative amnesia 10.3 HTR1A SMUG1
12 premature ejaculation 10.3 HTR1A SLC6A4
13 gastrointestinal tuberculosis 10.2 CRP SMUG1
14 aortitis 10.2 CRP SMUG1
15 cartilage disease 10.2 CRP SMUG1
16 alexithymia 10.2 CRP HTR1A SLC6A4
17 cold agglutinin disease 10.2 CRP IL6
18 cryopyrin-associated periodic syndrome 10.2 CRP IL6
19 endogenous depression 10.1 HTR1A NPY SLC6A4
20 acute cholangitis 10.1 CRP IL6
21 uremic pruritus 10.1 CRP IL6
22 neutrophilia, hereditary 10.1 CRP IL6
23 chronic fatigue syndrome 10.1 HTR1A IL6 SLC6A4
24 sphenoid sinusitis 10.1 CRP GOLPH3
25 bipolar disorder 10.1
26 spinal disease 10.1 CRP IL6
27 pulmonary aspergilloma 10.1 CRP SMUG1
28 viral pneumonia 10.1 CRP IL6
29 lactocele 10.1 PRL SMUG1
30 migraine with or without aura 1 10.1 GOLPH3 HTR1A SLC6A4
31 multicentric castleman disease 10.1 CRP IL6
32 social phobia 10.1 HTR1A PRL SLC6A4
33 sexual disorder 10.1 HTR1A PRL SLC6A4
34 migraine without aura 10.0 HTR1A PRL SLC6A4
35 stereotypic movement disorder 10.0 NPY PRL
36 coronary artery anomaly 10.0 ADRB1 CRP SMUG1
37 relapsing polychondritis 10.0 CRP IL6
38 subacute thyroiditis 10.0 CRP IL6
39 cluster headache 10.0 NPY PRL
40 intussusception 10.0 CRP IL6
41 systolic heart failure 10.0 ADRB1 CRP IL6
42 anovulation 10.0 CGA CRP PRL
43 louse-borne relapsing fever 10.0 CRP IL6
44 attention deficit-hyperactivity disorder 10.0 CHRNA7 HTR1A NPY SLC6A4
45 central nervous system vasculitis 10.0 CRP IL6 SMUG1
46 temporal arteritis 10.0 CRP IL6 SMUG1
47 cecal disease 9.9 CRP IL6
48 prader-willi syndrome 9.9
49 cognitive function 1, social 9.9
50 borderline personality disorder 9.9

Comorbidity relations with Intermittent Explosive Disorder via Phenotypic Disease Network (PDN):


Acute Cystitis Alzheimer Disease
Schizophreniform Disorder

Graphical network of the top 20 diseases related to Intermittent Explosive Disorder:



Diseases related to Intermittent Explosive Disorder

Symptoms & Phenotypes for Intermittent Explosive Disorder

MGI Mouse Phenotypes related to Intermittent Explosive Disorder:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.36 ADRB1 CGA CHRNA7 CRP GABRA2 HTR1A

Drugs & Therapeutics for Intermittent Explosive Disorder

Drugs for Intermittent Explosive Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 49)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Guanfacine Approved, Investigational Phase 4 29110-47-2 3519
2
Naratriptan Approved, Investigational Phase 4 121679-13-8, 143388-64-1 4440
3 Adrenergic Agonists Phase 4
4 Adrenergic alpha-2 Receptor Agonists Phase 4
5 Neurotransmitter Agents Phase 4,Phase 3,Phase 2
6 Adrenergic alpha-Agonists Phase 4
7 Adrenergic Agents Phase 4
8 Antihypertensive Agents Phase 4
9 Serotonin Agents Phase 4,Phase 3,Phase 2
10 Vasoconstrictor Agents Phase 4,Phase 1,Phase 2
11 Serotonin 5-HT1 Receptor Agonists Phase 4
12 Serotonin Receptor Agonists Phase 4
13
Serotonin Investigational, Nutraceutical Phase 4,Phase 3,Phase 2 50-67-9 5202
14
Dopamine Approved Phase 3 62-31-7, 51-61-6 681
15
Risperidone Approved, Investigational Phase 3 106266-06-2 5073
16
Carbidopa Approved Phase 3 28860-95-9 34359
17
Levodopa Approved Phase 3 59-92-7 6047
18 Central Nervous System Depressants Phase 3,Not Applicable
19 Dopamine Agents Phase 3
20 Psychotropic Drugs Phase 3,Phase 2
21 Serotonin Antagonists Phase 3
22 Antipsychotic Agents Phase 3
23 Dopamine Antagonists Phase 3
24 Tranquilizing Agents Phase 3
25 Immunologic Factors Phase 3
26 Aromatic Amino Acid Decarboxylase Inhibitors Phase 3
27 Adjuvants, Immunologic Phase 3
28 Antiparkinson Agents Phase 3
29 Dopamine agonists Phase 3
30 Carbidopa, levodopa drug combination Phase 3
31
Fluoxetine Approved, Vet_approved Phase 2 54910-89-3 3386
32
Quinidine Approved, Investigational Phase 2 56-54-2 441074
33 Hemostatics Phase 1, Phase 2
34 Hormones Phase 1, Phase 2
35 Natriuretic Agents Phase 1, Phase 2
36 Vasopressins Phase 1, Phase 2
37 Arginine Vasopressin Phase 1, Phase 2
38 SRX246 Phase 1, Phase 2
39 Coagulants Phase 1, Phase 2
40 Antidepressive Agents Phase 2
41 Neurotransmitter Uptake Inhibitors Phase 2
42 Cytochrome P-450 Enzyme Inhibitors Phase 2
43 Antidepressive Agents, Second-Generation Phase 2
44 Serotonin Uptake Inhibitors Phase 2
45 Cytochrome P-450 CYP2D6 Inhibitors Phase 2
46 Quinidine gluconate Phase 2
47
Ethanol Approved Not Applicable 64-17-5 702
48 Anti-Infective Agents, Local Not Applicable
49 Anti-Infective Agents Not Applicable

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Intuniv vs Placebo in the Treatment of Childhood Intermittent Explosive Disorder Completed NCT02048241 Phase 4 Intuniv
2 Efficacy of a Triptan in the Treatment of Hostility and Aggression Among Convicts With a Psychiatric Treatment Order Terminated NCT00282165 Phase 4 naratriptan;placebo
3 Study to Determine Whether There Are Any Cognitive or Motor Effects From Taking the Medicine Risperidone. Completed NCT00399698 Phase 3 Risperdal
4 Safety/Efficacy Study of Levodopa-Carbidopa Intestinal Gel in Parkinson's Subjects Completed NCT00360568 Phase 3 Levodopa-carbidopa intestinal gel
5 Levodopa-Carbidopa Intestinal Gel Open-Label Study in Advanced Parkinson's Disease Completed NCT00335153 Phase 3 Levodopa-carbidopa intestinal gel
6 Safety, Tolerability and Activity of SRX246 in Adults With Intermittent Explosive Disorder Completed NCT02055638 Phase 1, Phase 2 SRX246;Placebo
7 Psychotherapy for Intermittent Explosive Disorder Completed NCT00667212 Phase 2
8 A Comparison of Fluoxetine and Divalproex for the Treatment of Intermittent Explosive Disorder Completed NCT00078754 Phase 2 Fluoxetine;Divalproex;Placebo
9 A Pilot Study Comparing the Efficacy of Group Versus Individual Anger Management in Subjects With IED Completed NCT00127400 Phase 2
10 Study to Assess the Efficacy, Safety, and Tolerability of AVP-786 for the Treatment of Intermittent Explosive Disorder Terminated NCT03420222 Phase 2 AVP-786;Placebo
11 Alcohol Related Impairment and Reinforcement: Pre to Post Roux en Y Gastric Bypass Surgery Recruiting NCT02370732 Not Applicable

Search NIH Clinical Center for Intermittent Explosive Disorder

Genetic Tests for Intermittent Explosive Disorder

Anatomical Context for Intermittent Explosive Disorder

MalaCards organs/tissues related to Intermittent Explosive Disorder:

42
Amygdala, Brain

Publications for Intermittent Explosive Disorder

Articles related to Intermittent Explosive Disorder:

(show top 50) (show all 103)
# Title Authors Year
1
Emotion processing in intermittent explosive disorder. ( 30710810 )
2019
2
Aggression directed towards others vs. aggression directed towards the self: clinical differences between intermittent explosive disorder and nonsuicidal self-injury. ( 30843959 )
2019
3
DSM-5 intermittent explosive disorder: Relationship with Disruptive Mood Dysregulation Disorder. ( 29753187 )
2018
4
Major depressive disorder and depressive symptoms in intermittent explosive disorder. ( 29455060 )
2018
5
Treatment of Intermittent Explosive Disorder With Carbamazepine. ( 29533363 )
2018
6
Prevalence and clinical correlates of intermittent explosive disorder in Turkish psychiatric outpatients. ( 29604524 )
2018
7
Cognitive-behavioral group therapy for intermittent explosive disorder: description and preliminary analysis. ( 29590263 )
2018
8
Genome-Wide DNA Methylation Changes Associated with Intermittent Explosive Disorder: A Gene-Based Functional Enrichment Analysis. ( 29106553 )
2018
9
Psychosocial impairment in DSM-5 intermittent explosive disorder. ( 29627702 )
2018
10
The co-occurrence and correlates of anxiety disorders among adolescents with intermittent explosive disorder. ( 30040122 )
2018
11
Comorbidity of personality disorder with intermittent explosive disorder. ( 30240963 )
2018
12
Social desirability, deceptive reporting, and awareness of problematic aggression in intermittent explosive disorder compared with non-aggressive healthy and psychiatric controls. ( 30243128 )
2018
13
Subtypes of aggression in intermittent explosive disorder. ( 30551023 )
2018
14
Intermittent explosive disorder and eating disorders: Analysis of national comorbidity and research samples. ( 28324677 )
2017
15
Intermittent Explosive Disorder and Substance Use Disorder: Analysis of the National Comorbidity Survey Replication Sample. ( 28252880 )
2017
16
A Wait-List Controlled Study of a Trauma-Focused Cognitive Behavioral Treatment for Intermittent Explosive Disorder in Timor-Leste. ( 28749158 )
2017
17
Negative urgency and reward/punishment sensitivity in intermittent explosive disorder. ( 27155024 )
2016
18
Social cognition in Intermittent Explosive Disorder and aggression. ( 27621104 )
2016
19
Amygdala hyperactivation to angry faces in intermittent explosive disorder. ( 27145325 )
2016
20
Single Case Study: Neuropsychological Functioning in a Patient Diagnosed with Intermittent Explosive Disorder Pre and Post Neurosurgery. ( 27161981 )
2016
21
Differential fMRI BOLD responses in amygdala in intermittent explosive disorder as a function of past Alcohol Use Disorder. ( 27693977 )
2016
22
Comorbid intermittent explosive disorder and posttraumatic stress disorder: Clinical correlates and relationship to suicidal behavior. ( 27624432 )
2016
23
Substance use disorders: Relationship with intermittent explosive disorder and with aggression, anger, and impulsivity. ( 27442963 )
2016
24
The cross-national epidemiology of DSM-IV intermittent explosive disorder. ( 27572872 )
2016
25
Defense styles in Intermittent Explosive Disorder. ( 27086223 )
2016
26
Development of a screening questionnaire for DSM-5 intermittent explosive disorder (IED-SQ). ( 28088746 )
2016
27
White Matter Integrity Reductions in Intermittent Explosive Disorder. ( 27206265 )
2016
28
Prevalence of DSM-IV Intermittent Explosive Disorder in Black Adolescents: Findings From the National Survey of American Life, Adolescent Supplement. ( 27078052 )
2016
29
Frontolimbic Morphometric Abnormalities in Intermittent Explosive Disorder and Aggression. ( 29560894 )
2016
30
Effects of Escitalopram Administration on Face Processing in Intermittent Explosive Disorder: An fMRI Study. ( 26105140 )
2015
31
Emotional intelligence and impulsive aggression in Intermittent Explosive Disorder. ( 25477263 )
2015
32
Emotion regulation deficits in intermittent explosive disorder. ( 27539871 )
2015
33
Inflammatory markers and chronic exposure to fluoxetine, divalproex, and placebo in intermittent explosive disorder. ( 26277033 )
2015
34
Verbal versus physical aggression in Intermittent Explosive Disorder. ( 25534757 )
2015
35
The coherence and correlates of intermittent explosive disorder amongst West Papuan refugees displaced to Papua New Guinea. ( 25754605 )
2015
36
The experience of aggressive outbursts in Intermittent Explosive Disorder. ( 25541537 )
2015
37
Doing Psychiatry Right: A Case of Severe Avoidant Personality Disorder with Obsessive-compulsive Personality Disorder, Obsessive Compulsive Disorder, Intermittent Explosive Disorder and Sexual Paraphilias. ( 25035563 )
2014
38
Elevated Plasma Oxidative Stress Markers in Individuals with Intermittent Explosive Disorder and Correlation with Aggression in Humans. ( 24582164 )
2014
39
Intermittent explosive disorder: associations with PTSD and other Axis I disorders in a US military veteran sample. ( 24907536 )
2014
40
Validity of the new A1 and A2 criteria for DSM-5 intermittent explosive disorder. ( 24321204 )
2014
41
Intermittent Explosive Disorder and aversive parental care. ( 25064384 )
2014
42
Emotion regulation deficits in intermittent explosive disorder. ( 25403171 )
2014
43
Common and distinct neural correlates of inhibitory dysregulation: stroop fMRI study of cocaine addiction and intermittent explosive disorder. ( 25106072 )
2014
44
Self-harm behavior among individuals with intermittent explosive disorder and personality disorders. ( 25300440 )
2014
45
History of childhood maltreatment in intermittent explosive disorder and suicidal behavior. ( 24935900 )
2014
46
Relationship between psychopathy, aggression, anger, impulsivity, and intermittent explosive disorder. ( 24760575 )
2014
47
Intermittent explosive disorder: a study in personalized psychopharmacotherapy. ( 24441311 )
2014
48
Elevated Plasma Inflammatory Markers in Individuals With Intermittent Explosive Disorder and Correlation With Aggression in Humans. ( 24352431 )
2013
49
Achieving convergence between a community-based measure of explosive anger and a clinical interview for intermittent explosive disorder in Timor-Leste. ( 23835102 )
2013
50
Intermittent explosive disorder amongst women in conflict affected Timor-Leste: associations with human rights trauma, ongoing violence, poverty, and injustice. ( 23950885 )
2013

Variations for Intermittent Explosive Disorder

Expression for Intermittent Explosive Disorder

Search GEO for disease gene expression data for Intermittent Explosive Disorder.

GO Terms for Intermittent Explosive Disorder

Biological processes related to Intermittent Explosive Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.78 CGA IL6 NPY PRL
2 positive regulation of gene expression GO:0010628 9.73 CRP CTSH IL6 SLC6A4
3 cell proliferation GO:0008283 9.71 GOLPH3 HTR1A NPY PRL
4 positive regulation of JAK-STAT cascade GO:0046427 9.46 IL6 PRL
5 chemical synaptic transmission GO:0007268 9.46 CHRNA7 GABRA2 HTR1A NPY
6 vasoconstriction GO:0042310 9.37 HTR1A SLC6A4
7 negative regulation of organ growth GO:0046621 9.32 CGA SLC6A4
8 negative regulation of lipid storage GO:0010888 9.26 CRP IL6
9 regulation of postsynaptic membrane potential GO:0060078 9.13 ADRB1 CHRNA7 GABRA2
10 positive regulation of cell proliferation GO:0008284 9.1 CGA CHRNA7 CTSH HTR1A IL6 PRL

Molecular functions related to Intermittent Explosive Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.97 ADRB1 AURKA CGA CHRNA7 CRP CTSH
2 hormone activity GO:0005179 9.13 CGA NPY PRL
3 serotonin binding GO:0051378 8.62 HTR1A SLC6A4

Sources for Intermittent Explosive Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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