MCID: INT025
MIFTS: 41

Intermittent Explosive Disorder

Categories: Mental diseases

Aliases & Classifications for Intermittent Explosive Disorder

MalaCards integrated aliases for Intermittent Explosive Disorder:

Name: Intermittent Explosive Disorder 12 15 71
Explosive Personality Disorder 12 71

Classifications:



External Ids:

Disease Ontology 12 DOID:12401
ICD9CM 34 301.3 312.34
MeSH 43 D007174
NCIt 49 C94332
SNOMED-CT 67 231527003 40987004
ICD10 32 F60.3 F63.81
UMLS 71 C0021776 C0152183

Summaries for Intermittent Explosive Disorder

Disease Ontology : 12 An impulse control disorder that involves the episodic inability to control violent impulses with a disproportionate degree of aggressiveness.

MalaCards based summary : Intermittent Explosive Disorder, also known as explosive personality disorder, is related to pyromania and avoidant personality disorder. An important gene associated with Intermittent Explosive Disorder is SLC6A4 (Solute Carrier Family 6 Member 4), and among its related pathways/superpathways are Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways and Monoamine GPCRs. The drugs Guanfacine and Valproic acid have been mentioned in the context of this disorder. Affiliated tissues include brain, amygdala and testes, and related phenotypes are behavior/neurological and homeostasis/metabolism

Wikipedia : 74 Intermittent explosive disorder (sometimes abbreviated as IED) is a behavioral disorder characterized by... more...

Related Diseases for Intermittent Explosive Disorder

Diseases related to Intermittent Explosive Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 124)
# Related Disease Score Top Affiliating Genes
1 pyromania 31.8 SLITRK1 MAOA DRD2
2 avoidant personality disorder 31.0 SLC6A4 MAOA
3 obsessive-compulsive personality disorder 29.6 SLITRK1 SLC6A4 HTR2A COMT
4 depression 29.6 SLC6A4 MAOA HTR2C HTR2A HTR1A
5 oppositional defiant disorder 29.1 SLC6A4 MAOA DRD2 COMT
6 conduct disorder 29.0 SLC6A4 MAOA DRD2 COMT
7 alexithymia 28.8 SLC6A4 HTR1A DRD2 COMT
8 agoraphobia 28.8 SLC6A4 MAOA HTR2A HTR1A CTU2 COMT
9 eating disorder 28.8 SLC6A4 HTR2C HTR2A DRD2 COMT
10 personality disorder 28.8 SLC6A4 MAOA HTR2C HTR2A HTR1A DRD2
11 antisocial personality disorder 28.7 SLC6A4 MAOA HTR2A DRD2 COMT
12 anorexia nervosa 28.7 SLC6A4 MAOA HTR2C HTR2A HTR1A COMT
13 bulimia nervosa 28.6 SLC6A4 MAOA HTR2C HTR2A DRD2 COMT
14 anxiety 28.5 SLC6A4 MAOA HTR2C HTR2A HTR1A DRD2
15 post-traumatic stress disorder 28.5 SLC6A4 MAOA HTR2A HTR1A DRD2 COMT
16 alcohol use disorder 28.5 SLC6A4 HTR2C HTR2A HTR1A DRD2 COMT
17 mood disorder 28.3 SLC6A4 MAOA HTR2C HTR2A HTR1A DRD2
18 substance abuse 28.2 SLC6A4 MAOA HTR2A HTR1A DRD2 COMT
19 bipolar disorder 28.1 SLC6A4 MAOA HTR2C HTR2A HTR1A DRD2
20 borderline personality disorder 28.1 SLC6A4 MAOA HTR2C HTR2A HTR1A DRD2
21 mental depression 28.1 SLC6A4 MAOA HTR2C HTR2A HTR1A DRD2
22 generalized anxiety disorder 28.1 SLC6A4 MAOA HTR2C HTR2A HTR1A DRD2
23 impulse control disorder 28.0 SLITRK1 SLC6A4 MAOA HTR2A HTR1A DRD2
24 major depressive disorder 28.0 SLC6A4 MAOA HTR2C HTR2A HTR1A DRD2
25 alcohol dependence 27.8 SLC6A4 MAOA HTR2C HTR2A HTR1A DRD2
26 attention deficit-hyperactivity disorder 27.7 SLC6A4 MAOA HTR2C HTR2A HTR1A DRD2
27 obsessive-compulsive disorder 27.5 SLITRK1 SLC6A4 MAOA HTR2C HTR2A HTR1A
28 alcoholic psychosis 10.3 SLC6A4 HTR2A
29 somatization disorder 10.3 SLC6A4 HTR2A
30 severe combined immunodeficiency 10.2
31 dissociative disorder 10.2 SLC6A4 HTR2A
32 major affective disorder 8 10.2
33 major affective disorder 9 10.2
34 retrograde amnesia 10.1 SLC6A4 HTR1A
35 acute stress disorder 10.1
36 conversion disorder 10.1 HTR2A COMT
37 sleep apnea 10.0 SLC6A4 HTR2C HTR2A
38 adjustment disorder 10.0 SLC6A4 HTR2A HTR1A
39 body dysmorphic disorder 10.0 SLITRK1 SLC6A4 MAOA HTR2A
40 inhibited male orgasm 10.0 SLC6A4 HTR2C HTR1A
41 glossitis 10.0 SLC6A4 COMT
42 asperger syndrome 10.0 SLC6A4 COMT CGA
43 prader-willi syndrome 9.9
44 coronary heart disease 1 9.9
45 paraphilia disorder 9.9
46 asymptomatic neurosyphilis 9.9
47 craniopharyngioma 9.9
48 syphilis 9.9
49 tertiary syphilis 9.9
50 lung disease 9.9

Comorbidity relations with Intermittent Explosive Disorder via Phenotypic Disease Network (PDN):


Acute Cystitis Alzheimer Disease
Schizophreniform Disorder

Graphical network of the top 20 diseases related to Intermittent Explosive Disorder:



Diseases related to Intermittent Explosive Disorder

Symptoms & Phenotypes for Intermittent Explosive Disorder

MGI Mouse Phenotypes related to Intermittent Explosive Disorder:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.81 COMT DES DRD2 HTR1A HTR2A HTR2C
2 homeostasis/metabolism MP:0005376 9.65 CGA COMT DES DRD2 HTR1A HTR2C
3 nervous system MP:0003631 9.28 CGA COMT DRD2 HTR1A HTR2C MAOA

Drugs & Therapeutics for Intermittent Explosive Disorder

Drugs for Intermittent Explosive Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Guanfacine Approved, Investigational Phase 4 29110-47-2 3519
2
Valproic acid Approved, Investigational Phase 4 99-66-1 3121
3 Adrenergic alpha-Agonists Phase 4
4 Antihypertensive Agents Phase 4
5 Adrenergic Agents Phase 4
6 Adrenergic Agonists Phase 4
7 Neurotransmitter Agents Phase 4
8 Psychotropic Drugs Phase 4
9 Anticonvulsants Phase 4
10
Fluoxetine Approved, Vet_approved Phase 2 54910-89-3 3386
11
Quinidine Approved, Investigational Phase 2 56-54-2 441074
12 Hormones Phase 1, Phase 2
13 Vasopressins Phase 1, Phase 2
14 Arginine Vasopressin Phase 1, Phase 2
15 SRX246 Phase 1, Phase 2
16 Cytochrome P-450 Enzyme Inhibitors Phase 2
17 Antidepressive Agents Phase 2
18 Serotonin Uptake Inhibitors Phase 2
19 Quinidine gluconate Phase 2
20
Serotonin Investigational, Nutraceutical Phase 2 50-67-9 5202

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Intuniv vs Placebo in the Treatment of Childhood Intermittent Explosive Disorder Completed NCT02048241 Phase 4 Intuniv
2 Double Blind Placebo Controlled Study of Depakote (Divalproex Sodium) in Children With Temper Outbursts and Severe Mood Swings Completed NCT02078596 Phase 4 Divalproex
3 An Exploratory Phase II Study to Determine the Safety, Tolerability and Activity of a Novel Vasopressin 1a Receptor Antagonist (SRX246) in Adults With Diagnostic and Statistical Manual Version 5 (DSM-5) Intermittent Explosive Disorder (IED) Completed NCT02055638 Phase 1, Phase 2 SRX246;Placebo
4 A Pilot Study Comparing the Efficacy of Group Versus Individual Anger Management in Subjects With Intermittent Explosive Disorder Completed NCT00127400 Phase 2
5 Fluoxetine and Divalproex: Treatment Correlates in IED Completed NCT00078754 Phase 2 Fluoxetine;Divalproex;Placebo
6 Individual Cognitive Behavioral Psychotherapy for Intermittent Explosive Disorder Completed NCT00667212 Phase 2
7 A Phase 2, Multicenter, Randomized, Double-blind, Placebo-controlled Study to Assess the Efficacy, Safety, and Tolerability of AVP-786 (Deudextromethorphan Hydrobromide [d6-DM]/Quinidine Sulfate [Q]) for the Treatment of Intermittent Explosive Disorder (IED) Terminated NCT03420222 Phase 2 AVP-786;Placebo

Search NIH Clinical Center for Intermittent Explosive Disorder

Genetic Tests for Intermittent Explosive Disorder

Anatomical Context for Intermittent Explosive Disorder

MalaCards organs/tissues related to Intermittent Explosive Disorder:

40
Brain, Amygdala, Testes, Temporal Lobe, Heart

Publications for Intermittent Explosive Disorder

Articles related to Intermittent Explosive Disorder:

(show top 50) (show all 285)
# Title Authors PMID Year
1
Neuropsychiatric Aspects of Impulse Control Disorders. 61
32439020 2020
2
History of childhood abuse and alcohol use disorder: Relationship with intermittent explosive disorder and intoxicated aggression frequency. 61
32203738 2020
3
Dimensions over categories: a meta-analysis of taxometric research. 61
32493520 2020
4
The Overt Aggression Scale Modified (OAS-M) for clinical trials targeting impulsive aggression and intermittent explosive disorder: Validity, reliability, and correlates. 61
32114032 2020
5
Prevalence and psychiatric comorbidities of intermittent explosive disorders in Metropolitan São Paulo, Brazil. 61
32285139 2020
6
Self-injurious thoughts and behaviors that differentiate soldiers who attempt suicide from those with recent suicide ideation. 61
32291817 2020
7
Disordered Aggression and Violence in the United States. 61
32220154 2020
8
Comorbidity of disruptive behavior disorders and intermittent explosive disorder. 61
32514306 2020
9
Gray Matter Deficits and Dysfunction in the Insula Among Individuals With Intermittent Explosive Disorder. 61
32508687 2020
10
Neurosyphilis Presenting as Intermittent Explosive Disorder and Acute Psychosis. 61
31938625 2019
11
Psychiatric comorbidity in Intermittent Explosive Disorder. 61
31487607 2019
12
Evidence for the taxonic latent structure for DSM-5 intermittent explosive disorder in adults. 61
31680661 2019
13
5-HT2c agonist, lorcaserin, reduces aggressive responding in intermittent explosive disorder: A pilot study. 61
31774584 2019
14
Habenula-prefrontal resting-state connectivity in reactive aggressive men - A pilot study. 61
30366001 2019
15
Comorbidity profile of mental disorders among adolescents: A latent class analysis. 61
31226549 2019
16
Aggression directed towards others vs. aggression directed towards the self: clinical differences between intermittent explosive disorder and nonsuicidal self-injury. 61
30843959 2019
17
Compulsive sexual behavior disorder in obsessive-compulsive disorder: Prevalence and associated comorbidity. 61
31079471 2019
18
Scales to assess impulsive and compulsive behaviors in Parkinson's disease: Critique and recommendations. 61
31136681 2019
19
Transition to suicide attempt from recent suicide ideation in U.S. Army soldiers: Results from the Army Study to Assess Risk and Resilience in Servicemembers (Army STARRS). 61
30549394 2019
20
Emotion processing in intermittent explosive disorder. 61
30710810 2019
21
Subtypes of aggression in intermittent explosive disorder. 61
30551023 2019
22
Prior Mental Disorders and Lifetime Suicidal Behaviors Among US Army Soldiers in the Army Study to Assess Risk and Resilience in Servicemembers (Army STARRS). 61
28926674 2019
23
Intermittent Explosive Disorder in Male Juvenile Delinquents in China. 61
31404282 2019
24
Potential Deep Brain Stimulation Targets for the Management of Refractory Hypertension. 61
30858796 2019
25
Relationship between quality of life in young adults and impulsivity/compulsivity✰. 61
30504061 2019
26
Social desirability, deceptive reporting, and awareness of problematic aggression in intermittent explosive disorder compared with non-aggressive healthy and psychiatric controls. 61
30243128 2018
27
Comorbidity of personality disorder with intermittent explosive disorder. 61
30240963 2018
28
The co-occurrence and correlates of anxiety disorders among adolescents with intermittent explosive disorder. 61
30040122 2018
29
Suicidal behavior and aggression-related disorders. 61
28829989 2018
30
DSM-5 intermittent explosive disorder: Relationship with Disruptive Mood Dysregulation Disorder. 61
29753187 2018
31
Cognitive-behavioral group therapy for intermittent explosive disorder: description and preliminary analysis. 61
29590263 2018
32
Psychosocial impairment in DSM-5 intermittent explosive disorder. 61
29627702 2018
33
Construct validity and parent-child agreement of the six new or modified disorders included in the Spanish version of the Kiddie Schedule for Affective Disorders and Schizophrenia present and Lifetime Version DSM-5 (K-SADS-PL-5). 61
29529472 2018
34
Prevalence and clinical correlates of intermittent explosive disorder in Turkish psychiatric outpatients. 61
29604524 2018
35
Aggression is associated with greater subsequent alcohol consumption: A shared neural basis in the ventral striatum. 61
29417595 2018
36
Major depressive disorder and depressive symptoms in intermittent explosive disorder. 61
29455060 2018
37
Prader-Willi syndrome genetic subtypes and clinical neuropsychiatric diagnoses in residential care adults. 61
28984907 2018
38
Treatment of Intermittent Explosive Disorder With Carbamazepine. 61
29533363 2018
39
Mild Traumatic Brain Injury and Aggression, Impulsivity, and History of Other- and Self-Directed Aggression. 61
29505319 2018
40
Genome-Wide DNA Methylation Changes Associated with Intermittent Explosive Disorder: A Gene-Based Functional Enrichment Analysis. 61
29106553 2018
41
A wait-list controlled study of a trauma-focused cognitive behavioral treatment for intermittent explosive disorder in Timor-Leste. 61
28749158 2018
42
Problematic internet use in gamblers: impact on clinical and cognitive measures. 61
28893336 2017
43
Weeding Out the Justification for Marijuana Treatment in Patients with Developmental and Behavioral Conditions. 61
28622159 2017
44
Generalized hostile interpretation bias regarding facial expressions: Characteristic of pathological aggressive behavior. 61
28191653 2017
45
Intermittent Explosive Disorder and Substance Use Disorder: Analysis of the National Comorbidity Survey Replication Sample. 61
28252880 2017
46
Intermittent explosive disorder and eating disorders: Analysis of national comorbidity and research samples. 61
28324677 2017
47
Development of a screening questionnaire for DSM-5 intermittent explosive disorder (IED-SQ). 61
28088746 2017
48
Social emotional information processing in adults: Development and psychometrics of a computerized video assessment in healthy controls and aggressive individuals. 61
28012305 2017
49
Subjective anger and overt aggression in psychiatric outpatients. 61
27855338 2017
50
Pattern and risk of developing alcohol use disorders, illegal substance use and psychiatric disorders after early onset of alcohol use: Results of the Thai National Mental Health Survey 2013. 61
27883946 2017

Variations for Intermittent Explosive Disorder

Expression for Intermittent Explosive Disorder

Search GEO for disease gene expression data for Intermittent Explosive Disorder.

Pathways for Intermittent Explosive Disorder

Pathways related to Intermittent Explosive Disorder according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1 11.88 SLC6A4 MAOA HTR2A HTR1A
2
Show member pathways
11.66 HTR2C HTR2A HTR1A DRD2
3 11.61 SLC6A4 MAOA HTR2C HTR2A HTR1A
4 11.52 HTR2C HTR2A DRD2
5
Show member pathways
10.85 MAOA COMT
6
Show member pathways
10.83 SLC6A4 MAOA COMT
7 10.8 HTR2C HTR2A
8 10.8 SLC6A4 MAOA HTR2C HTR2A HTR1A
9 10.78 HTR2C DRD2
10
Show member pathways
10.66 MAOA COMT
11 10.58 MAOA COMT
12
Show member pathways
10.38 SLC6A4 MAOA HTR1A DRD2 COMT

GO Terms for Intermittent Explosive Disorder

Cellular components related to Intermittent Explosive Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 dendrite GO:0030425 9.55 HTR2C HTR2A HTR1A DRD2 COMT
2 integral component of presynaptic membrane GO:0099056 9.43 SLC6A4 HTR2A DRD2
3 synapse GO:0045202 9.17 ZNRF1 SLITRK1 SLC6A4 HTR2C HTR2A HTR1A
4 integral component of postsynaptic membrane GO:0099055 9.13 SLC6A4 HTR2A DRD2

Biological processes related to Intermittent Explosive Disorder according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.65 SLC6A4 HTR2C HTR2A DRD2 COMT
2 adult behavior GO:0030534 9.58 SLITRK1 DRD2
3 behavioral fear response GO:0001662 9.58 HTR2C HTR1A
4 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 9.58 HTR2C HTR2A HTR1A
5 G protein-coupled serotonin receptor signaling pathway GO:0098664 9.57 HTR2A HTR1A
6 temperature homeostasis GO:0001659 9.56 HTR2A DRD2
7 behavioral response to cocaine GO:0048148 9.55 HTR2A DRD2
8 vasoconstriction GO:0042310 9.54 SLC6A4 HTR1A
9 release of sequestered calcium ion into cytosol GO:0051209 9.54 HTR2C HTR2A DRD2
10 negative regulation of synaptic transmission, glutamatergic GO:0051967 9.52 HTR2A DRD2
11 dopamine metabolic process GO:0042417 9.51 DRD2 COMT
12 catecholamine metabolic process GO:0006584 9.49 MAOA COMT
13 negative regulation of organ growth GO:0046621 9.48 SLC6A4 CGA
14 neurotransmitter catabolic process GO:0042135 9.46 MAOA COMT
15 dopamine catabolic process GO:0042420 9.43 MAOA COMT
16 positive regulation of phosphatidylinositol biosynthetic process GO:0010513 9.32 HTR2C HTR2A
17 phospholipase C-activating serotonin receptor signaling pathway GO:0007208 9.16 HTR2C HTR2A
18 behavior GO:0007610 9.13 HTR2C HTR2A HTR1A
19 serotonin receptor signaling pathway GO:0007210 8.8 HTR2C HTR2A HTR1A

Molecular functions related to Intermittent Explosive Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.21 ZNRF1 WDR59 SLITRK1 SLC6A4 MAOA ITGB3BP
2 neurotransmitter receptor activity GO:0030594 9.5 HTR2C HTR2A HTR1A
3 drug binding GO:0008144 9.43 HTR2C HTR2A DRD2
4 G protein-coupled serotonin receptor activity GO:0004993 9.33 HTR2C HTR2A HTR1A
5 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding GO:0071886 8.96 HTR2C HTR2A
6 serotonin binding GO:0051378 8.92 SLC6A4 HTR2C HTR2A HTR1A

Sources for Intermittent Explosive Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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