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MCID: INT059
MIFTS: 39

Internal Hemorrhoid

Categories: Cardiovascular diseases, Gastrointestinal diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Internal Hemorrhoid

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MalaCards integrated aliases for Internal Hemorrhoid:

Name: Internal Hemorrhoid 12 15
Internal Hemorrhoids 73

Classifications:

MalaCards categories:
Anatomical: Cardiovascular diseases Gastrointestinal diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:9749
ICD9CM 35 455.6
SNOMED-CT 68 82985000
ICD10 33 I84.1 I84.2
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Summaries for Internal Hemorrhoid

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MalaCards based summary : Internal Hemorrhoid, also known as internal hemorrhoids, is related to hemorrhoid and brain glioblastoma multiforme. An important gene associated with Internal Hemorrhoid is MMP9 (Matrix Metallopeptidase 9), and among its related pathways/superpathways are Integrin Pathway and Cytokine Signaling in Immune system. The drugs Lidocaine and Prilocaine have been mentioned in the context of this disorder. Affiliated tissues include liver, and related phenotypes are cellular and homeostasis/metabolism

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Related Diseases for Internal Hemorrhoid

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Diseases in the Hemorrhoid family:

Internal Hemorrhoid

Diseases related to Internal Hemorrhoid via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 82)
# Related Disease Score Top Affiliating Genes
1 hemorrhoid 33.1 MMP9 NOS2
2 brain glioblastoma multiforme 10.6 MMP7 MMP9
3 chronic actinic dermatitis 10.6 MMP1 MMP9
4 pediatric multiple sclerosis 10.6 MMP7 MMP9
5 extracranial arteriovenous malformation 10.6 MMP2 MMP9
6 chromoblastomycosis 10.6 MMP1 MMP9
7 mycetoma 10.6 MMP9 NOS2
8 lentigo maligna melanoma 10.6 MMP2 MMP9
9 villous adenocarcinoma 10.6 MMP2 MMP9
10 acute transverse myelitis 10.6 MMP2 MMP9
11 ischemic colitis 10.5 MMP2 MMP9
12 parotitis 10.5 MMP2 MMP9
13 conjunctival nevus 10.5 MMP2 MMP9
14 klatskin's tumor 10.5 MMP2 MMP9
15 middle ear squamous cell carcinoma 10.5 CD34 MMP9
16 microcystic meningioma 10.5 MMP2 MMP9
17 corneal ulcer 10.5 MMP2 MMP9
18 nasal cavity squamous cell carcinoma 10.5 MMP2 MMP9
19 transverse myelitis 10.5 MMP2 MMP9
20 sorsby fundus dystrophy 10.5 MMP2 MMP9
21 collagenous colitis 10.5 MMP1 NOS2
22 lung giant cell carcinoma 10.4 MMP2 MMP9
23 chronic venous insufficiency 10.4 MMP1 MMP9
24 fibromatosis, gingival, 1 10.4 MMP1 MMP2
25 pelvic organ prolapse 10.4 MMP1 MMP9
26 venous insufficiency 10.4 MMP1 MMP9
27 conjunctivochalasis 10.4 MMP1 MMP2
28 coronary artery aneurysm 10.4 MMP1 MMP7
29 nodular malignant melanoma 10.3 MMP1 MMP2
30 tongue cancer 10.3 MMP2 MMP9
31 pneumothorax 10.3 MMP2 MMP9
32 tendinopathy 10.2 CASP3 MMP1
33 adult astrocytic tumour 10.2 MMP1 MMP7 MMP9
34 pulmonary emphysema 10.2 MMP1 MMP9
35 focal myositis 10.2 MMP2 MMP7 MMP9
36 senile ectropion 10.2 MMP2 MMP7 MMP9
37 carotid artery disease 10.2 MMP1 MMP9
38 adenomyosis 10.1 MMP1 MMP2 MMP9
39 odontogenic myxoma 10.1 MMP1 MMP2 MMP9
40 hypertensive heart disease 10.1 MMP1 MMP2 MMP9
41 aortic aneurysm, familial thoracic 1 10.1 MMP1 MMP2 MMP9
42 pharynx cancer 10.1 CASP3 MMP9
43 inguinal hernia 10.1 MMP1 MMP2 MMP9
44 pulmonary fibrosis, idiopathic 10.1 MMP1 MMP7 MMP9
45 aortic aneurysm, familial abdominal, 1 10.1 MMP1 MMP2 MMP9
46 periodontitis 10.1 MMP1 MMP2 MMP9
47 periodontal disease 10.1 MMP1 MMP2 MMP9
48 fibrosarcoma 10.1 MMP1 MMP2 MMP9
49 keratoconus 10.0 MMP1 MMP2 MMP9
50 photokeratitis 10.0 HSPA4 MMP9

Graphical network of the top 20 diseases related to Internal Hemorrhoid:



Diseases related to Internal Hemorrhoid
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Symptoms & Phenotypes for Internal Hemorrhoid

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MGI Mouse Phenotypes related to Internal Hemorrhoid:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.98 MMP9 NOS2 ACE2 CASP3 CD34 HSPA4
2 homeostasis/metabolism MP:0005376 9.97 ACE2 CASP3 CD34 MMP1 MMP2 MMP7
3 cardiovascular system MP:0005385 9.93 ACE2 CASP3 MMP2 MMP7 MMP9 NOS2
4 immune system MP:0005387 9.92 ACE2 CASP3 CD34 MMP1 MMP2 MMP7
5 digestive/alimentary MP:0005381 9.8 ACE2 CASP3 MMP7 MMP9 NOS2
6 muscle MP:0005369 9.65 ACE2 CASP3 MMP2 MMP9 NOS2
7 neoplasm MP:0002006 9.63 CD34 MMP1 MMP2 MMP7 MMP9 NOS2
8 respiratory system MP:0005388 9.35 ACE2 CASP3 MMP2 MMP9 NOS2
9 vision/eye MP:0005391 9.02 CASP3 MMP2 MMP7 MMP9 NOS2
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Drugs & Therapeutics for Internal Hemorrhoid

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Drugs for Internal Hemorrhoid (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lidocaine Approved, Vet_approved Phase 3 137-58-6 3676
2
Prilocaine Approved Phase 3 721-50-6 4906
3 Central Nervous System Depressants Phase 3
4 Sodium Channel Blockers Phase 3
5 Anesthetics Phase 3
6 Anesthetics, Local Phase 3
7 Diuretics, Potassium Sparing Phase 3
8 Anti-Arrhythmia Agents Phase 3
9 Peripheral Nervous System Agents Phase 3
10
Hydrocortisone Approved, Vet_approved Phase 2 50-23-7 5754
11
Butyric Acid Experimental, Investigational Phase 2 107-92-6 264
12 Cortisol succinate Phase 2
13 Hydrocortisone 17-butyrate 21-propionate Phase 2
14 Hydrocortisone acetate Phase 2
15 Hydrocortisone-17-butyrate Phase 2
16 Anti-Inflammatory Agents Phase 2

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 Topical Anesthesia Versus Placebo to Decrease Pain in Rubber Band Ligation for Treatment of Internal Hemorrhoids Completed NCT02130830 Phase 3 Topical 2,5% lidocaine + 2,5% prilocaine gel;Placebo
2 Study About Patient Comfort and Long-term Outcome After Stapled Hemorrhoidopexy Completed NCT01533363 Phase 3
3 Efficacy and Safety Study to Treat Subjects With Symptomatic Internal Hemorrhoids Terminated NCT01355874 Phase 3 Iferanserin;Placebo;Iferanserin + Placebo
4 Safety and Efficacy Study of Anucort HC TM 25mg Rectal Suppositories to Treat Symptomatic Internal Hemorrhoids Completed NCT01913158 Phase 2 Anucort-HC, 25 Mg Rectal Suppository;Placebo suppository
5 Study of the Safety and Efficacy of Hydrocortisone Acetate Suppositories, 25 mg in the Treatment of Symptomatic Internal Hemorrhoids Not yet recruiting NCT03335774 Phase 2 Hydrocortisone Acetate Suppository, 25 mg;Placebo (Vehicle) Suppository
6 A Multi Center Clinical Trial of Rph With the Simplified Milligan-Morgan Surgery on Treatment of Mixed Hemorrhoids Unknown status NCT02306421 Not Applicable
7 Comparison Between Single and Triple Rubber Band Ligation for the Treatment of Hemorrhoids Unknown status NCT01383577 Not Applicable
8 HET Bipolar System: Validation of Outpatient Hemorrhoid Treatment Unknown status NCT02773420 Not Applicable
9 Comparison Between Two Endoscopic Treatments of Bleeding Internal Hemorrhoids:Band Ligation and Electrocoagulation Probe Completed NCT00630669 Not Applicable
10 Safety and Efficacy Study of HET Bipolar System for Treatment of Stage I and Stage II Hemorrhoids Completed NCT01841970 Not Applicable
11 Multicenter Prospective Trial on Hemorrhoids Recruiting NCT03245086
12 Rubber Band Ligation and Mucosectomy for Gastroesophageal Reflux Disease (GERD) Terminated NCT01199679 Not Applicable

Search NIH Clinical Center for Internal Hemorrhoid

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Genetic Tests for Internal Hemorrhoid

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Anatomical Context for Internal Hemorrhoid

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MalaCards organs/tissues related to Internal Hemorrhoid:

41
Liver
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Publications for Internal Hemorrhoid

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Articles related to Internal Hemorrhoid:

# Title Authors Year
1
Rectal arterio-venous malformation (AVM) with bleeding of an internal hemorrhoid. ( 26879656 )
2016
2
Pyogenic liver abscess as a complication of internal hemorrhoid banding. ( 24480193 )
2014
3
Massive life-threatening lower gastrointestinal hemorrhage caused by an internal hemorrhoid in a patient receiving antiplatelet therapy: a case report. ( 23089912 )
2012
4
Long-term outcome and efficacy of endoscopic hemorrhoid ligation for symptomatic internal hemorrhoids. ( 21633644 )
2011
5
Stapled hemorrhoidopexy is associated with a higher long-term recurrence rate of internal hemorrhoids compared with conventional excisional hemorrhoid surgery. ( 17665254 )
2007
6
Early results of the treatment of internal hemorrhoid disease by infrared coagulation and elastic banding: a prospective randomized cross-over trial. ( 17115317 )
2006
7
[Pathologic change of elastic fibers with difference of microvessel density and expression of angiogenesis-related proteins in internal hemorrhoid tissues]. ( 16149003 )
2005
8
Internal hemorrhoid bleeding in patients with portal hypertension. ( 3498664 )
1987
9
INTERNAL HEMORRHOID OPERATION AND AFTER CARE UNDER QUININE-UREA HYDROCHLORIDE ANESTHESIA. ( 18737501 )
1918
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Variations for Internal Hemorrhoid

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Expression for Internal Hemorrhoid

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Search GEO for disease gene expression data for Internal Hemorrhoid.
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Pathways for Internal Hemorrhoid

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Pathways related to Internal Hemorrhoid according to GeneCards Suite gene sharing:

(show all 31)
# Super pathways Score Top Affiliating Genes
1
Integrin Pathway 64
Show member pathways
 13.15 CASP3 MMP1 MMP2 MMP7 MMP9
2
Cytokine Signaling in Immune system 66
Show member pathways
 13.09 CASP3 MMP1 MMP2 MMP9 NOS2
3
Circadian entrainment 37
Show member pathways
 12.79 MMP1 MMP2 MMP9 NOS2
4
Pathways in cancer 37
12.63 CASP3 MMP1 MMP2 MMP9 NOS2
5
Degradation of the extracellular matrix 66
Show member pathways
 12.55 CASP3 MMP1 MMP2 MMP7 MMP9
6
Development EGFR signaling pathway 22
Show member pathways
 12.31 CASP3 MMP2 MMP9
7
IL-17 Family Signaling Pathways 65
Show member pathways
 12.11 CASP3 MMP1 MMP9
8
Proteoglycans in cancer 37
12.08 CASP3 MMP2 MMP9
9
Spinal Cord Injury 1
11.82 CASP3 MMP9 NOS2
10
Interleukin-4 and 13 signaling 66
11.76 MMP1 MMP2 MMP9 NOS2
11
Angiogenesis (CST) 4
11.68 MMP2 MMP7 MMP9
12
Matrix Metalloproteinases 1
Show member pathways
 11.66 MMP1 MMP2 MMP7 MMP9
13
Bladder cancer 37 1
11.59 MMP1 MMP2 MMP9
14
LPA receptor mediated events 1
11.53 CASP3 MMP2 MMP9
15
Hepatitis C and Hepatocellular Carcinoma 1
11.41 CASP3 MMP1 NOS2
16
ATF-2 transcription factor network 1
11.39 MMP2 NOS2
17
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.36 MMP1 MMP2 MMP9 NOS2
18
amb2 Integrin signaling 1
11.32 MMP2 MMP9
19
Colorectal Cancer Metastasis 64
11.32 CASP3 MMP1 MMP2 MMP7 MMP9 NOS2
20
Integrated Cancer Pathway 1
11.3 CASP3 MMP1
21
Osteopontin-mediated events 1
Show member pathways
 11.29 MMP2 MMP9
22
Cell adhesion_ECM remodeling 22
11.24 MMP1 MMP2 MMP7 MMP9
23
Cell adhesion_Cell-matrix glycoconjugates 22
11.22 MMP1 MMP9
24
Validated transcriptional targets of AP1 family members Fra1 and Fra2 1
11.18 MMP1 MMP2 MMP9
25
AGE/RAGE pathway 1
11.17 CASP3 MMP2 MMP7 MMP9 NOS2
26
A-beta Pathways: Uptake and Degradation 65
11.14 ACE2 MMP2 MMP9
27
Syndecan-2-mediated signaling events 1
11.13 CASP3 MMP2
28
Plasma membrane estrogen receptor signaling 1
11.01 MMP2 MMP9
29
A-beta Pathways: Plaque Formation and APP Metabolism 65
10.97 ACE2 MMP2 MMP9
30
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 66
10.9 MMP1 MMP2
31
Syndecan-1-mediated signaling events 1
10.73 MMP1 MMP7 MMP9
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GO Terms for Internal Hemorrhoid

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Cellular components related to Internal Hemorrhoid according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.43 ACE2 CD34 MMP1 MMP2 MMP7 MMP9
2 extracellular matrix GO:0031012 8.92 MMP1 MMP2 MMP7 MMP9

Biological processes related to Internal Hemorrhoid according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 9.73 ACE2 CASP3 MMP1 MMP2 MMP7 MMP9
2 leukocyte migration GO:0050900 9.58 CD34 MMP1 MMP9
3 cytokine-mediated signaling pathway GO:0019221 9.55 CASP3 MMP1 MMP2 MMP9 NOS2
4 response to hypoxia GO:0001666 9.5 CASP3 MMP2 NOS2
5 embryo implantation GO:0007566 9.46 MMP2 MMP9
6 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.43 MMP2 MMP9
7 endodermal cell differentiation GO:0035987 9.37 MMP2 MMP9
8 extracellular matrix disassembly GO:0022617 9.26 MMP1 MMP2 MMP7 MMP9
9 collagen catabolic process GO:0030574 8.92 MMP1 MMP2 MMP7 MMP9

Molecular functions related to Internal Hemorrhoid according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hydrolase activity GO:0016787 9.88 ACE2 CASP3 MMP1 MMP2 MMP7 MMP9
2 zinc ion binding GO:0008270 9.77 ACE2 MMP1 MMP2 MMP7 MMP9
3 serine-type endopeptidase activity GO:0004252 9.56 MMP1 MMP2 MMP7 MMP9
4 endopeptidase activity GO:0004175 9.5 ACE2 MMP1 MMP9
5 metalloendopeptidase activity GO:0004222 9.46 MMP1 MMP2 MMP7 MMP9
6 peptidase activity GO:0008233 9.43 ACE2 CASP3 MMP1 MMP2 MMP7 MMP9
7 metallopeptidase activity GO:0008237 9.02 ACE2 MMP1 MMP2 MMP7 MMP9
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Sources for Internal Hemorrhoid

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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