Home
User Guide
What's in a MalaCard Search Guide Our Sources
Analysis Tools
GeneCards GeneAnalytics GeneAlaCart PathCards VarElect TGex
News and Views Disease Lists/Categories
About
About MalaCards Our Publications Weizmann Institute LifeMap Discovery® Terms of Use MalaCards Team
MCID: INT059
MIFTS: 44

Internal Hemorrhoid

Categories: Cardiovascular diseases, Gastrointestinal diseases, Skin diseases
Genes Tissues Related diseases Publications Pathways Drugs
Sources

Aliases & Classifications for Internal Hemorrhoid

About this section

MalaCards integrated aliases for Internal Hemorrhoid:

Name: Internal Hemorrhoid 12 15
Internal Hemorrhoids 73

Classifications:

MalaCards categories:
Anatomical: Cardiovascular diseases Gastrointestinal diseases Skin diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:9749
ICD9CM 35 455.6
SNOMED-CT 68 82985000
ICD10 33 I84.1 I84.2
Sources

Summaries for Internal Hemorrhoid

About this section
MalaCards based summary : Internal Hemorrhoid, also known as internal hemorrhoids, is related to hemorrhoid and pelvic organ prolapse. An important gene associated with Internal Hemorrhoid is MMP9 (Matrix Metallopeptidase 9), and among its related pathways/superpathways are Circadian entrainment and Pathways in cancer. The drugs Prilocaine and Lidocaine have been mentioned in the context of this disorder. Affiliated tissues include skin, lung and brain, and related phenotypes are Mildly decreased CFP-tsO45G cell surface transport and homeostasis/metabolism

Sources

Related Diseases for Internal Hemorrhoid

About this section

Diseases in the Hemorrhoid family:

Internal Hemorrhoid

Diseases related to Internal Hemorrhoid via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 75)
# Related Disease Score Top Affiliating Genes
1 hemorrhoid 32.8 MMP9 NOS2
2 pelvic organ prolapse 30.2 MMP1 MMP9
3 brain glioblastoma multiforme 10.2 MMP7 MMP9
4 pediatric multiple sclerosis 10.2 MMP7 MMP9
5 chronic actinic dermatitis 10.2 MMP1 MMP9
6 mycetoma 10.2 MMP9 NOS2
7 chromoblastomycosis 10.2 MMP1 MMP9
8 middle ear squamous cell carcinoma 10.2 CD34 MMP9
9 extracranial arteriovenous malformation 10.1 MMP2 MMP9
10 chronic venous insufficiency 10.1 MMP1 MMP9
11 villous adenocarcinoma 10.1 MMP2 MMP9
12 venous insufficiency 10.1 MMP1 MMP9
13 lentigo maligna melanoma 10.1 MMP2 MMP9
14 acute transverse myelitis 10.1 MMP2 MMP9
15 transverse myelitis 10.1 MMP2 MMP9
16 ischemic colitis 10.1 MMP2 MMP9
17 conjunctival nevus 10.1 MMP2 MMP9
18 parotitis 10.1 MMP2 MMP9
19 klatskin's tumor 10.1 MMP2 MMP9
20 preterm premature rupture of the membranes 10.1 MMP1 MMP9
21 corneal ulcer 10.1 MMP2 MMP9
22 coronary artery aneurysm 10.1 MMP1 MMP7
23 nasal cavity squamous cell carcinoma 10.1 MMP2 MMP9
24 pulmonary emphysema 10.1 MMP1 MMP9
25 carotid stenosis 10.1 MMP1 MMP9
26 fibromatosis, gingival, 1 10.1 MMP1 MMP2
27 laryngeal disease 10.1 MMP2 MMP9
28 intravascular fasciitis 10.1 ALK CD34
29 conjunctivochalasis 10.1 MMP1 MMP2
30 septic arthritis 10.1 MMP1 MMP2
31 adenomyosis 10.1 MMP2 MMP9
32 mesenchymal cell neoplasm 10.1 ALK CD34
33 spinal cord injury 10.1 MMP9 NOS2
34 collagenous colitis 10.1 MMP1 MMP9 NOS2
35 carotid artery disease 10.1 MMP1 MMP9
36 intraneural perineurioma 10.1 ALK CD34
37 adult astrocytic tumour 10.1 MMP1 MMP7 MMP9
38 pediatric lymphoma 10.1 ALK CD34
39 gingival fibromatosis 10.0 MMP1 MMP2
40 pulmonary fibrosis, idiopathic 10.0 MMP1 MMP7 MMP9
41 focal myositis 10.0 MMP2 MMP7 MMP9
42 senile ectropion 10.0 MMP2 MMP7 MMP9
43 photokeratitis 10.0 HSPA4 MMP9
44 odontogenic myxoma 10.0 MMP1 MMP2 MMP9
45 hypertensive heart disease 10.0 MMP1 MMP2 MMP9
46 aortic aneurysm, familial thoracic 1 10.0 MMP1 MMP2 MMP9
47 inguinal hernia 10.0 MMP1 MMP2 MMP9
48 aortic aneurysm, familial abdominal, 1 10.0 MMP1 MMP2 MMP9
49 periodontitis 10.0 MMP1 MMP2 MMP9
50 periodontal disease 10.0 MMP1 MMP2 MMP9

Graphical network of the top 20 diseases related to Internal Hemorrhoid:



Diseases related to Internal Hemorrhoid
Sources

Symptoms & Phenotypes for Internal Hemorrhoid

About this section

GenomeRNAi Phenotypes related to Internal Hemorrhoid according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Mildly decreased CFP-tsO45G cell surface transport GR00360-A-1 9.17 ACE2 ALK CD34 HSPA4 MMP1 MMP2

MGI Mouse Phenotypes related to Internal Hemorrhoid:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.97 ACE2 ALK CD34 MMP1 MMP2 MMP7
2 immune system MP:0005387 9.87 ACE2 CD34 MMP1 MMP2 MMP7 MMP9
3 neoplasm MP:0002006 9.7 ALK CD34 MMP1 MMP2 MMP7 MMP9
4 integument MP:0010771 9.65 ACE2 ALK CD34 MMP9 NOS2
5 respiratory system MP:0005388 9.35 ACE2 ALK MMP2 MMP9 NOS2
6 vision/eye MP:0005391 9.02 ALK MMP2 MMP7 MMP9 NOS2
Sources

Drugs & Therapeutics for Internal Hemorrhoid

About this section

Drugs for Internal Hemorrhoid (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prilocaine Approved Phase 3 721-50-6 4906
2
Lidocaine Approved, Vet_approved Phase 3 137-58-6 3676
3 Peripheral Nervous System Agents Phase 3
4 Sodium Channel Blockers Phase 3
5 Diuretics, Potassium Sparing Phase 3
6 Anti-Arrhythmia Agents Phase 3
7 Anesthetics, Local Phase 3
8 Central Nervous System Depressants Phase 3
9 Anesthetics Phase 3
10
Hydrocortisone Approved, Vet_approved Phase 2 50-23-7 5754
11
Hydrocortisone acetate Approved, Vet_approved Phase 2 50-03-3
12 Hydrocortisone 17-butyrate 21-propionate Phase 2
13 Hydrocortisone-17-butyrate Phase 2
14 Anti-Inflammatory Agents Phase 2
15 Cortisol succinate Phase 2

Interventional clinical trials:

(show all 13)
# Name Status NCT ID Phase Drugs
1 Topical Anesthesia Versus Placebo to Decrease Pain in Rubber Band Ligation for Treatment of Internal Hemorrhoids Completed NCT02130830 Phase 3 Topical 2,5% lidocaine + 2,5% prilocaine gel;Placebo
2 Study About Patient Comfort and Long-term Outcome After Stapled Hemorrhoidopexy Completed NCT01533363 Phase 3
3 Efficacy and Safety Study to Treat Subjects With Symptomatic Internal Hemorrhoids Terminated NCT01355874 Phase 3 Iferanserin;Placebo;Iferanserin + Placebo
4 Safety and Efficacy Study of Anucort HC TM 25mg Rectal Suppositories to Treat Symptomatic Internal Hemorrhoids Completed NCT01913158 Phase 2 Anucort-HC, 25 Mg Rectal Suppository;Placebo suppository
5 Study of the Safety and Efficacy of Hydrocortisone Acetate Suppositories, 25 mg in the Treatment of Symptomatic Internal Hemorrhoids Not yet recruiting NCT03335774 Phase 2 Hydrocortisone Acetate Suppository, 25 mg;Placebo (Vehicle) Suppository
6 Efficacy of Lidocaine Gel Enema After Endoscopic Hemorrhoid Band Ligation for Relief of Post Procedural Pain Recruiting NCT03797703 Phase 1 Lidocaine Hydrochloride 2% gel enema
7 A Multi Center Clinical Trial of Rph With the Simplified Milligan-Morgan Surgery on Treatment of Mixed Hemorrhoids Unknown status NCT02306421 Not Applicable
8 Comparison Between Single and Triple Rubber Band Ligation for the Treatment of Hemorrhoids Unknown status NCT01383577 Not Applicable
9 HET Bipolar System: Validation of Outpatient Hemorrhoid Treatment Unknown status NCT02773420 Not Applicable
10 Comparison Between Two Endoscopic Treatments of Bleeding Internal Hemorrhoids:Band Ligation and Electrocoagulation Probe Completed NCT00630669 Not Applicable
11 Safety and Efficacy Study of HET Bipolar System for Treatment of Stage I and Stage II Hemorrhoids Completed NCT01841970 Not Applicable
12 Multicenter Prospective Trial on Hemorrhoids Recruiting NCT03245086
13 Rubber Band Ligation and Mucosectomy for Gastroesophageal Reflux Disease (GERD) Terminated NCT01199679 Not Applicable

Search NIH Clinical Center for Internal Hemorrhoid

Sources

Genetic Tests for Internal Hemorrhoid

About this section
Sources

Anatomical Context for Internal Hemorrhoid

About this section

MalaCards organs/tissues related to Internal Hemorrhoid:

41
Skin, Lung, Brain, Bone, Heart, Tongue, Spinal Cord
Sources

Publications for Internal Hemorrhoid

About this section

Articles related to Internal Hemorrhoid:

(show top 50) (show all 92)
# Title Authors Year
1
Laparoscopic rectal tumor surgery after administration of a new sclerosing therapy (aluminum potassium sulfate and tannic acid injection) for internal hemorrhoids: A report of three cases. ( 30411508 )
2018
2
Transanal hemorrhoidal dearterialization (THD) versus stapled hemorrhoidopexy (SH) in treatment of internal hemorrhoids: a systematic review and meta-analysis of randomized clinical trials. ( 30421308 )
2018
3
Endoscopic treatment of internal hemorrhoids by use of a bipolar system. ( 30182083 )
2017
4
Rectal arterio-venous malformation (AVM) with bleeding of an internal hemorrhoid. ( 26879656 )
2016
5
Prospective Case Series of a Novel Minimally Invasive Bipolar Coagulation System in the Treatment of Grade I and II Internal Hemorrhoids. ( 27448595 )
2016
6
Operative management of internal hemorrhoids. ( 25594292 )
2015
7
Treatment of Internal Hemorrhoids by Endoscopic Sclerotherapy with Aluminum Potassium Sulfate and Tannic Acid. ( 26246785 )
2015
8
Pyogenic liver abscess as a complication of internal hemorrhoid banding. ( 24480193 )
2014
9
Endoscopic sclerotherapy with aluminum potassium sulfate and tannic acid for internal hemorrhoids. ( 24676816 )
2014
10
Serum aluminum levels in dialysis patients after sclerotherapy of internal hemorrhoids with aluminum potassium sulfate and tannic acid. ( 24817127 )
2014
11
Comparing the effect of An's Shaobei Injection ([symbols; see text]) with Xiaozhiling Injection ([symbols; see text]) in patients with internal hemorrhoids of grade I-III: a prospective cohort study. ( 24972583 )
2014
12
A unique nonsurgical management of internal hemorrhoids by Jīmūtaka Lepa. ( 25538354 )
2014
13
Nonsurgical treatment of actively bleeding internal hemorrhoids with a novel endoscopic device (with video). ( 23891414 )
2013
14
Impact of less invasive treatments including sclerotherapy with a new agent and hemorrhoidopexy for prolapsing internal hemorrhoids. ( 23971772 )
2013
15
Massive life-threatening lower gastrointestinal hemorrhage caused by an internal hemorrhoid in a patient receiving antiplatelet therapy: a case report. ( 23089912 )
2012
16
ALTA injection sclerosing therapy:non-excisional treatment of internal hemorrhoids. ( 22260824 )
2012
17
Novel endoscopic delivery modality of infrared coagulation therapy for internal hemorrhoids. ( 22648099 )
2012
18
Management of internal hemorrhoids by Kshara karma: An educational case report. ( 23125506 )
2012
19
Aluminum potassium sulfate and tannic acid (ALTA) injection as the mainstay of treatment for internal hemorrhoids. ( 21626327 )
2011
20
Invasive cancer in a diminutive rectal polyp amidst internal hemorrhoids detected by rectal retroflexion. ( 20689479 )
2010
21
Evaluation of sclerotherapy with a new sclerosing agent and stapled hemorrhoidopexy for prolapsing internal hemorrhoids: retrospective comparison with hemorrhoidectomy. ( 21063123 )
2010
22
Comparison between Ultroid and rubber band ligation in treatment of internal hemorrhoids. ( 21287479 )
2010
23
Definitive therapy for internal hemorrhoids--new opportunities and options. ( 19367214 )
2009
24
Randomized prospective study of endoscopic rubber band ligation compared with bipolar coagulation for chronically bleeding internal hemorrhoids. ( 19513028 )
2009
25
Strangulation of internal hemorrhoids complicating sclerosing therapy with injection of OC-108 (Zione). ( 16468029 )
2007
26
Early results of the treatment of internal hemorrhoid disease by infrared coagulation and elastic banding: a prospective randomized cross-over trial. ( 17115317 )
2006
27
Sclerosing therapy of internal hemorrhoids with a novel sclerosing agent. Comparison with ligation and excision. ( 15843937 )
2006
28
[Pathologic change of elastic fibers with difference of microvessel density and expression of angiogenesis-related proteins in internal hemorrhoid tissues]. ( 16149003 )
2005
29
Colonoscopic classification of internal hemorrhoids: usefulness in endoscopic band ligation. ( 15610445 )
2005
30
The superior rectal artery and its branching pattern with regard to its clinical influence on ligation techniques for internal hemorrhoids. ( 14706597 )
2004
31
Retroflexed endoscopic multiple band ligation of symptomatic internal hemorrhoids. ( 14997135 )
2004
32
Long-term outcome of rubber band ligation for symptomatic primary and recurrent internal hemorrhoids. ( 15484351 )
2004
33
Endoscopic hemorrhoidal ligation of symptomatic internal hemorrhoids. ( 14652555 )
2003
34
Retroflexed endoscopic band ligation of bleeding internal hemorrhoids. ( 11923767 )
2002
35
Comparative study between multiple and single rubber band ligation in one session for bleeding internal, hemorrhoids: a prospective study. ( 12117024 )
2002
36
Rubber band ligation of symptomatic internal hemorrhoids: results of 500 cases. ( 10720835 )
2000
37
Treatment of acute strangulated internal hemorrhoids by topical application of isosorbide dinitrate ointment. ( 11008728 )
2000
38
Comparative clinical evaluation of "kshara injection technique" in the management of internal hemorrhoids. ( 22556917 )
1999
39
Internal hemorrhoids coexisting with chronic anal fissure: new nonsurgical modalities. ( 9865581 )
1998
40
Resolution of chronic anal fissures after treatment of contiguous internal hemorrhoids with direct current probe. ( 9041002 )
1997
41
Micronized flavonoid therapy in internal hemorrhoids of pregnancy. ( 9184951 )
1997
42
Prospective randomized comparative study of bipolar electrocoagulation versus heater probe for treatment of chronically bleeding internal hemorrhoids. ( 9402118 )
1997
43
Nonsurgical treatment options for internal hemorrhoids. ( 7653423 )
1995
44
A novel therapy for internal hemorrhoids: ligation of the hemorrhoidal artery with a newly devised instrument (Moricorn) in conjunction with a Doppler flowmeter. ( 7717320 )
1995
45
Prospective randomized comparative study of bipolar versus direct current electrocoagulation for treatment of bleeding internal hemorrhoids. ( 7926528 )
1994
46
Randomized, prospective trial of direct current versus bipolar electrocoagulation for bleeding internal hemorrhoids. ( 8293898 )
1993
47
Complications of rubber band ligation of symptomatic internal hemorrhoids. ( 8449135 )
1993
48
Sclerotherapy of internal hemorrhoids using newly devised transparent disposable anorectoscope. ( 1502679 )
1992
49
Internal hemorrhoids: diagnosis with double-contrast barium enema examinations. ( 2399313 )
1990
50
A personal experience in comparing three nonoperative techniques for treating internal hemorrhoids. ( 2719004 )
1989
Sources

Variations for Internal Hemorrhoid

About this section
Sources

Expression for Internal Hemorrhoid

About this section
Search GEO for disease gene expression data for Internal Hemorrhoid.
Sources

Pathways for Internal Hemorrhoid

About this section

Pathways related to Internal Hemorrhoid according to GeneCards Suite gene sharing:

(show all 25)
# Super pathways Score Top Affiliating Genes
1
Circadian entrainment 37
Show member pathways
 12.75 MMP1 MMP2 MMP9 NOS2
2
Pathways in cancer 37
12.61 ALK MMP1 MMP2 MMP9 NOS2
3
Degradation of the extracellular matrix 66
Show member pathways
 12.5 MMP1 MMP2 MMP7 MMP9
4
G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins 22
Show member pathways
 11.97 MMP1 MMP2 MMP7 MMP9
5
Microglia Activation During Neuroinflammation: Overview 65
Show member pathways
 11.81 MMP2 MMP7 MMP9
6
Interleukin-4 and 13 signaling 66
11.76 MMP1 MMP2 MMP9 NOS2
7
Matrix Metalloproteinases 1
Show member pathways
 11.66 MMP1 MMP2 MMP7 MMP9
8
Angiogenesis (CST) 4
11.65 MMP2 MMP7 MMP9
9
Bladder cancer 37 1
11.55 MMP1 MMP2 MMP9
10
Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF) 22
Show member pathways
 11.39 HSPA4 NOS2
11
AGE/RAGE pathway 1
11.38 MMP2 MMP7 MMP9 NOS2
12
ATF-2 transcription factor network 1
11.36 MMP2 NOS2
13
Hepatitis C and Hepatocellular Carcinoma 1
11.32 MMP1 NOS2
14
amb2 Integrin signaling 1
11.29 MMP2 MMP9
15
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.26 MMP1 MMP2 MMP9 NOS2
16
Osteopontin-mediated events 1
Show member pathways
 11.25 MMP2 MMP9
17
Colorectal Cancer Metastasis 64
11.24 MMP1 MMP2 MMP7 MMP9 NOS2
18
Cell adhesion_Cell-matrix glycoconjugates 22
11.18 MMP1 MMP9
19
Validated transcriptional targets of AP1 family members Fra1 and Fra2 1
11.18 MMP1 MMP2 MMP9
20
A-beta Pathways: Uptake and Degradation 65
11.14 ACE2 MMP2 MMP9
21
Cell adhesion_ECM remodeling 22
11.04 MMP1 MMP2 MMP7 MMP9
22
Plasma membrane estrogen receptor signaling 1
10.99 MMP2 MMP9
23
A-beta Pathways: Plaque Formation and APP Metabolism 65
10.97 ACE2 MMP2 MMP9
24
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 66
10.88 MMP1 MMP2
25
Syndecan-1-mediated signaling events 1
10.73 MMP1 MMP7 MMP9
Sources

GO Terms for Internal Hemorrhoid

About this section

Cellular components related to Internal Hemorrhoid according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.43 ACE2 CD34 MMP1 MMP2 MMP7 MMP9
2 extracellular matrix GO:0031012 8.92 MMP1 MMP2 MMP7 MMP9

Biological processes related to Internal Hemorrhoid according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 9.65 ACE2 MMP1 MMP2 MMP7 MMP9
2 leukocyte migration GO:0050900 9.54 CD34 MMP1 MMP9
3 regulation of cell proliferation GO:0042127 9.5 ACE2 ALK NOS2
4 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.46 MMP2 MMP9
5 cytokine-mediated signaling pathway GO:0019221 9.46 MMP1 MMP2 MMP9 NOS2
6 embryo implantation GO:0007566 9.43 MMP2 MMP9
7 endodermal cell differentiation GO:0035987 9.4 MMP2 MMP9
8 extracellular matrix disassembly GO:0022617 9.26 MMP1 MMP2 MMP7 MMP9
9 collagen catabolic process GO:0030574 8.92 MMP1 MMP2 MMP7 MMP9

Molecular functions related to Internal Hemorrhoid according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hydrolase activity GO:0016787 9.8 ACE2 MMP1 MMP2 MMP7 MMP9
2 zinc ion binding GO:0008270 9.77 ACE2 MMP1 MMP2 MMP7 MMP9
3 serine-type endopeptidase activity GO:0004252 9.56 MMP1 MMP2 MMP7 MMP9
4 peptidase activity GO:0008233 9.55 ACE2 MMP1 MMP2 MMP7 MMP9
5 endopeptidase activity GO:0004175 9.5 ACE2 MMP1 MMP9
6 metalloendopeptidase activity GO:0004222 9.26 MMP1 MMP2 MMP7 MMP9
7 metallopeptidase activity GO:0008237 9.02 ACE2 MMP1 MMP2 MMP7 MMP9
Sources

Sources for Internal Hemorrhoid

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Content
Loading form....