MCID: INT059
MIFTS: 34

Internal Hemorrhoid

Categories: Cardiovascular diseases, Gastrointestinal diseases, Skin diseases

Aliases & Classifications for Internal Hemorrhoid

MalaCards integrated aliases for Internal Hemorrhoid:

Name: Internal Hemorrhoid 12 15
Internal Hemorrhoids 71

Classifications:



External Ids:

Disease Ontology 12 DOID:9749
ICD9CM 34 455.6
SNOMED-CT 67 82985000
ICD10 32 I84.1 I84.2
UMLS 71 C0041844 C0265034

Summaries for Internal Hemorrhoid

Disease Ontology : 12 A hemorrhoid that is located in the rectum.

MalaCards based summary : Internal Hemorrhoid, also known as internal hemorrhoids, is related to hemorrhoid and anal fistula. An important gene associated with Internal Hemorrhoid is MMP9 (Matrix Metallopeptidase 9). The drugs Polidocanol and Sclerosing Solutions have been mentioned in the context of this disorder. Affiliated tissues include rectum, colon and lymph node.

Related Diseases for Internal Hemorrhoid

Diseases in the Hemorrhoid family:

Internal Hemorrhoid

Diseases related to Internal Hemorrhoid via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 139)
# Related Disease Score Top Affiliating Genes
1 hemorrhoid 31.4 VAT1 NOS2 MMP9 FLNA ATP4A ATP12A
2 anal fistula 30.4 MMP9 APOLD1
3 angiodysplasia 30.0 ATP4A ATP12A
4 dieulafoy lesion 29.7 ATP4A ATP12A APOLD1
5 constipation 29.2 NOS2 FLNA ATP4A ATP12A APOLD1
6 lateral ventricle meningioma 10.4 MMP9 APOLD1
7 mycetoma 10.4 NOS2 MMP9
8 collagenous colitis 10.3 NOS2 MMP9
9 anaerobic meningitis 10.2 FLNA APOLD1
10 pelvic organ prolapse 10.2
11 senile ectropion 10.2 MMP9 FLNA
12 angiokeratoma of fordyce 10.2 MMP9 FLNA
13 spinal cord injury 10.2 NOS2 MMP9
14 pelvic varices 10.2 VAT1 APOLD1
15 polycystic echinococcosis 10.2 FLNA APOLD1
16 vagus nerve disease 10.1 ATP4A ATP12A
17 hemangioma of intra-abdominal structure 10.1 ATP4A ATP12A
18 acquired gastric outlet stenosis 10.1 ATP4A ATP12A
19 displacement of cardia through esophageal hiatus 10.1 ATP4A ATP12A
20 angiodysplasia of intestine 10.1 ATP4A ATP12A
21 benzylpenicillin allergy 10.1 ATP4A ATP12A
22 penicillin allergy 10.1 ATP4A ATP12A
23 granulomatous gastritis 10.1 ATP4A ATP12A
24 bacterial esophagitis 10.1 ATP4A ATP12A
25 lingual goiter 10.1 ATP4A ATP12A
26 cascade stomach 10.1 ATP4A ATP12A
27 gastrojejunal ulcer 10.1 ATP4A ATP12A
28 median arcuate ligament syndrome 10.1 ATP4A ATP12A
29 laryngeal tuberculosis 10.1 ATP4A ATP12A
30 fungal esophagitis 10.1 ATP4A ATP12A
31 esophagus melanoma 10.1 ATP4A ATP12A
32 emphysematous cholecystitis 10.1 ATP4A ATP12A
33 necrotizing gastritis 10.1 ATP4A ATP12A
34 cervix erosion 10.1 ATP4A ATP12A
35 pneumatosis cystoides intestinalis 10.1 ATP4A ATP12A
36 gastric gastrinoma 10.1 ATP4A ATP12A
37 superior mesenteric artery syndrome 10.1 ATP4A ATP12A
38 chronic laryngitis 10.1 ATP4A ATP12A
39 laryngitis 10.1 ATP4A ATP12A
40 cefuroxime allergy 10.1 ATP4A ATP12A
41 polyposis, skin pigmentation, alopecia, and fingernail changes 10.1 ATP4A ATP12A
42 chronic intestinal vascular insufficiency 10.1 ATP4A ATP12A
43 peptic ulcer perforation 10.1 ATP4A ATP12A
44 rumination disorder 10.1 ATP4A ATP12A
45 blind loop syndrome 10.1 ATP4A ATP12A
46 acute laryngitis 10.1 ATP4A ATP12A
47 gastroduodenitis 10.1 ATP4A ATP12A
48 duodenitis 10.1 ATP4A ATP12A
49 duodenal gastrinoma 10.1 ATP4A ATP12A
50 gastric hemangioma 10.1 ATP4A ATP12A

Graphical network of the top 20 diseases related to Internal Hemorrhoid:



Diseases related to Internal Hemorrhoid

Symptoms & Phenotypes for Internal Hemorrhoid

Drugs & Therapeutics for Internal Hemorrhoid

Drugs for Internal Hemorrhoid (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Polidocanol Approved Phase 4 9002-92-0
2 Sclerosing Solutions Phase 4
3 Pharmaceutical Solutions Phase 4
4
Prilocaine Approved Phase 3 721-50-6 4906
5
Hydrocortisone Approved, Vet_approved Phase 2 50-23-7 5754
6
Hydrocortisone acetate Approved, Vet_approved Phase 2 50-03-3
7
Imidacloprid Vet_approved Phase 1, Phase 2 105827-78-9 86418
8 Hydrocortisone-17-butyrate Phase 2
9 Hydrocortisone 17-butyrate 21-propionate Phase 2
10 Anti-Inflammatory Agents Phase 2
11 Hydrocortisone hemisuccinate Phase 2
12
Lidocaine Approved, Vet_approved Phase 1 137-58-6 3676
13 Sodium Channel Blockers Phase 1
14 Anti-Arrhythmia Agents Phase 1
15 Anesthetics Phase 1
16 Diuretics, Potassium Sparing Phase 1
17 Anesthetics, Local Phase 1
18
Hesperidin Approved, Investigational 520-26-3 53477767
19 Hemostatics

Interventional clinical trials:

(show all 23)
# Name Status NCT ID Phase Drugs
1 A Multicenter Prospective Clinical Study of Endoscopic Foam Sclerotherapy for Internal Hemorrhoids Recruiting NCT04398823 Phase 4 Sclerosing foam of Lauromacrogol;Sclersing liqiud of Lauromacrogol
2 Topical Anesthesia Versus Placebo to Decrease Post Procedure Pain in Rubber Band Ligation for the Treatment of Grade I - III Symptomatic Internal Hemorrhoids. A Single Institution, Double Blinded, Placebo Controlled Trial. Completed NCT02130830 Phase 3 Topical 2,5% lidocaine + 2,5% prilocaine gel;Placebo
3 Patient Comfort After Stapled Hemorrhoidopexy Long Term Results of a Randomized Controlled Trial Completed NCT01533363 Phase 3
4 A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Parallel-Treatment Group, Multicenter Efficacy and Safety Study of Intra-Anal Application of Iferanserin (10 mg) as a 0.5% Ointment in Subjects With Symptomatic Internal Hemorrhoids Terminated NCT01355874 Phase 3 Iferanserin;Placebo;Iferanserin + Placebo
5 A Randomized, Double-Blind, Vehicle-Controlled, Multicenter Study to Evaluate Safety and Efficacy of Anucort HC TM (Hydrocortisone Acetate) 25mg Rectal Suppositories in the Treatment of Symptomatic Internal Hemorrhoids Completed NCT01913158 Phase 2 Anucort-HC, 25 Mg Rectal Suppository;Placebo suppository
6 Double-blind, Randomized, Placebo-controlled, Dose Response Study to Evaluate the Safety and Efficacy of Three Doses of Euphorbia Prostrata Dry Extract Tablets in Patients of Hemorrhoids Completed NCT01041911 Phase 2 Euphorbia tablets;Euphorbia tablets;Euphorbia tablets;Placebo tablets
7 Feasibility Study of a New Circular Anal Dilator for Transanal Hemorrhoidectomy Completed NCT00693459 Phase 1, Phase 2
8 A Randomized, Double-blind, Placebo-controlled, Multicenter, Parallel Group Study of the Safety and Efficacy of Hydrocortisone Acetate Suppositories, 25 mg Compared to Placebo Suppositories in the Treatment of Symptomatic Internal Hemorrhoids Recruiting NCT03335774 Phase 2 Hydrocortisone Acetate Suppository, 25 mg;Placebo (Vehicle) Suppository
9 Sclerotherapy With Polidocanol Foam Versus Rubber Band Ligation in the Treatment of First, Second and Third-Grade Hemorrhoidal Disease: a Randomized, Controlled Trial Recruiting NCT04091763 Phase 2 Polidocanol Injectable Foam
10 Efficacy of Lidocaine Gel Enema After Endoscopic Hemorrhoid Band Ligation for Relief of Post Procedural Pain Recruiting NCT03797703 Phase 1 Lidocaine Hydrochloride 2% gel enema
11 A Multi Center Clinical Trial of the Efficacy and Safety of Rph With the Simplified Milligan-Morgan Surgery on Treatment of Mixed Hemorrhoids Unknown status NCT02306421
12 Multi-center, Non-randomized Prospective Observation Study Comparing Ferguson Hemorrhoidectomy and Transanal Hemorrhoidal Dearterialization (THD) for Prolapsed, Nonincarcerated, Reducible Hemorrhoids in Terms of 1-year Recurrence Unknown status NCT03245086
13 An Investigation Into the Relationship Between Hemorrhoid Disease and the Use of Smartphones in the Lavatory Unknown status NCT03444389
14 Double-blind Randomized Controlled Study of Single Versus Triple Rubber Band Ligation of Hemorrhoids Unknown status NCT01383577
15 Randomized Study Of Endoscopic Band Ligation Versus Bipolar Probe Electrocoagulation Of Bleeding Internal Hemorrhoids Completed NCT00630669
16 Multi-Center, Prospective Study of the Safety and Efficacy of the HET Bipolar System for Treatment of Stage I and Stage II Hemorrhoids Completed NCT01841970
17 Cap-assisted Endoscopic Sclerotherapy for Internal Hemorrhoids and Rectal Prolapse: a Nationwide Multicenter Randomized Controlled Trial Recruiting NCT03917056
18 Multicentrique Prospective Evaluation of Radiofrequency Surgical Treatment of Homorrhoidal Disease Recruiting NCT04229784
19 Upper Rectal Artery Embolization in the Treatment of Hemorrhoidal Disease Recruiting NCT03402282
20 Ligasure Hemorrhoidectomy Versus Open Hemorrhoidectomy. A Randomized Clinical Trial on the Long-term Effect on Hemorrhoidal Symptoms Recruiting NCT04139876
21 Cap-assisted Endoscopic Sclerotherapy for Internal Hemorrhoids and Rectal Prolapse: a National Multi-centre Prospective Cohort Study Not yet recruiting NCT04169152
22 Comparative Study of Band Ligation and Phlebotonic Drug Versus Only Phlebotonic Drug, in Bleeding Internal Hemorrhoids. Not yet recruiting NCT04290351 oral 450 mg diosmin+50 mg hesperidin
23 Evaluation of Distal Esophageal and Cardia Rubber Band Ligation and Mucosectomy in the Treatment of Subjects With Gastroesophageal Reflux Disease Terminated NCT01199679

Search NIH Clinical Center for Internal Hemorrhoid

Genetic Tests for Internal Hemorrhoid

Anatomical Context for Internal Hemorrhoid

The Foundational Model of Anatomy Ontology organs/tissues related to Internal Hemorrhoid:

19
Rectum

MalaCards organs/tissues related to Internal Hemorrhoid:

40
Colon, Lymph Node, Skin, Liver, Testes, Spinal Cord

Publications for Internal Hemorrhoid

Articles related to Internal Hemorrhoid:

(show top 50) (show all 338)
# Title Authors PMID Year
1
Rubber Band Ligation of Hemorrhoids is often a Necessary Complement in the Management of Hemorrhagic Radiation Proctitis. 61
30632450 2020
2
Assessment of pediatric Crohn's disease activity: validation of the magnetic resonance enterography global score (MEGS) against endoscopic activity score (SES-CD). 61
32458027 2020
3
Polidocanol versus phenol in oil injection sclerotherapy in treatment of internal hemorrhoids: A randomized controlled trial. 61
32519957 2020
4
Fundamentals of Anorectal Technical Skills: A Concise Surgical Skills Course. 61
32313930 2020
5
CT colonography has low sensitivity but high specificity in the detection of internal hemorrhoids. 61
32116218 2020
6
The Management of Acute Hemorrhoidal Disease. 61
32223737 2020
7
Network meta-analysis of randomized controlled trials comparing the procedure for prolapse and hemorrhoids, Milligan-Morgan hemorrhoidectomy and tissue-selecting therapy stapler in the treatment of grade III and IV internal hemorrhoids(Meta-analysis). 61
31887419 2020
8
Cap-assisted endoscopic sclerotherapy for internal hemorrhoids: technique protocol and study design for a multi-center randomized controlled trial. 61
32551439 2020
9
[Submucosal laser ablation of internal hemorrhoids]. 61
32271744 2020
10
Video anoscopy: results of routine anal examination during colonoscopies. 61
31723578 2019
11
Endoscopic Sclerotherapy with Aluminum Potassium Sulfate and Tannic Acid: An Effective and Less Invasive Strategy for Internal Hemorrhoids. 61
31722520 2019
12
Effectiveness of Endoscopic Sclerotherapy with Aluminum Potassium Sulfate and Tannic Acid as a Non-Surgical Treatment for Internal Hemorrhoids. 61
31337196 2019
13
Treatment of hemorrhoids: A survey of surgical practice in Australia and New Zealand. 61
31799299 2019
14
Laparoscopic rectal tumor surgery after administration of a new sclerosing therapy (aluminum potassium sulfate and tannic acid injection) for internal hemorrhoids: A report of three cases. 61
30411508 2019
15
Robot-assisted low anterior resection after aluminum potassium sulfate and tannic acid sclerosing therapy for internal hemorrhoids. 61
31664540 2019
16
Hemorrhoid Banding: A Cost-Effectiveness Analysis. 61
31318773 2019
17
Hemorrhoid Energy Therapy for Treatment of Deep Chronic Anal Fissures. 61
31737710 2019
18
Comparison of the effect of Myrtus communis herbal and anti-hemorrhoid ointments on the hemorrhoid symptoms and quality of life in postpartum women with grade I and II internal hemorrhoid: A triple-blinded randomized controlled clinical trial. 61
31433782 2019
19
Piles of Money: "Hemorrhoids" Are a Billion-Dollar Industry. 61
30998519 2019
20
Polidocanol Foam Injected at High Doses with Intravenous Needle: The (Almost) Perfect Treatment of Symptomatic Internal Hemorrhoids. 61
31192285 2019
21
Pre-operative assessment of internal mucosal rectal prolapse in internal hemorrhoids: technical details and results from a single institution. 61
31125011 2019
22
Polidocanol Foam: A Breath of Fresh Air for the Treatment of Internal Hemorrhoids. 61
31192282 2019
23
Pathophysiology of internal hemorrhoids. 61
31040623 2019
24
THD Doppler: A Reliable Surgical Procedure to Treat Hemorrhoids. 61
30888670 2019
25
An Incidental Finding of Anemia: Rectal Adenocarcinoma in a Young Adult. 61
31275778 2019
26
Transanal hemorrhoidal dearterialization (THD) versus stapled hemorrhoidopexy (SH) in treatment of internal hemorrhoids: a systematic review and meta-analysis of randomized clinical trials. 61
30421308 2019
27
Clopidogrel bisulfate (Plavix) does not increase bleeding complications in patients undergoing rubber band ligation for symptomatic hemorrhoids. 61
29936995 2018
28
Hemorrhoids: Diagnosis and Treatment Options. 61
29431977 2018
29
Endoscopic treatment of internal hemorrhoids by use of a bipolar system. 61
30182083 2017
30
A Randomized Controlled Trial Comparing Laser Intra-Hemorrhoidal Coagulation and Milligan-Morgan Hemorrhoidectomy. 61
27806213 2017
31
Liver injury after aluminum potassium sulfate and tannic acid treatment of hemorrhoids. 61
28785156 2017
32
Comparative clinical study of Apamarga Kshara application, infrared coagulation and Arshohara Vati in the management of Arsha (1st and 2nd degree hemorrhoids). 61
30254391 2017
33
Management of internal bleeding piles by ligation and plication followed by Matra Basti - A case report. 61
30254394 2017
34
[A multicenter, randomized controlled trial of wheat cellulose particles in the treatment of internal hemorrhoids]. 61
28722093 2017
35
Partial stapled hemorrhoidopexy: clinical aspects and impact on anorectal physiology. 61
28767804 2017
36
Effect of a mixture of diosmin, coumarin glycosides, and triterpenes on bleeding, thrombosis, and pain after stapled anopexy: a prospective, randomized, placebo-controlled clinical trial. 61
27815700 2017
37
Comparison of Postoperative Results after Hemorrhoidectomy Using Local and Spinal Anesthesia. 61
29927176 2017
38
Japanese Practice Guidelines for Anal Disorders I. Hemorrhoids. 61
31583307 2017
39
Treatment of Complete Anal Stricture after Diverting Colostomy for Fournier's Gangrene. 61
28255493 2017
40
Prospective Case Series of a Novel Minimally Invasive Bipolar Coagulation System in the Treatment of Grade I and II Internal Hemorrhoids. 61
27448595 2016
41
Safety and efficacy of superior rectal artery embolization with particles and metallic coils for the treatment of hemorrhoids (Emborrhoid technique). 61
27597728 2016
42
Microbiota Composition, HSP70 and Caspase-3 Expression as Marker for Colorectal Cancer Patients in Aceh, Indonesia. 61
28143990 2016
43
Rubber band ligation of hemorrhoids: A guide for complications. 61
27721924 2016
44
Rectal Blue Nevus: Distinguishing Features of a Rare Entity. 61
28008401 2016
45
Diffuse Cavernous Hemangioma of the Colon. 61
27821043 2016
46
Anorectal emergencies. 61
27468181 2016
47
Comparison of a Hemorrhoidectomy With Ultrasonic Scalpel Versus a Conventional Hemorrhoidectomy. 61
27437393 2016
48
Capsule Endoscopy with Retention of the Capsule in a Duodenal Diverticulum: A Case Report. 61
27112247 2016
49
Manual reduction in acute haemorrhoids. 61
27212575 2016
50
Rectal arterio-venous malformation (AVM) with bleeding of an internal hemorrhoid. 61
26879656 2016

Variations for Internal Hemorrhoid

Expression for Internal Hemorrhoid

Search GEO for disease gene expression data for Internal Hemorrhoid.

Pathways for Internal Hemorrhoid

GO Terms for Internal Hemorrhoid

Cellular components related to Internal Hemorrhoid according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cortical cytoskeleton GO:0030863 8.62 NOS2 FLNA

Biological processes related to Internal Hemorrhoid according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 potassium ion import across plasma membrane GO:1990573 9.37 ATP4A ATP12A
2 negative regulation of protein catabolic process GO:0042177 9.32 NOS2 FLNA
3 cellular sodium ion homeostasis GO:0006883 9.26 ATP4A ATP12A
4 sodium ion export across plasma membrane GO:0036376 9.16 ATP4A ATP12A
5 cellular potassium ion homeostasis GO:0030007 8.96 ATP4A ATP12A
6 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 8.62 ATP4A ATP12A

Molecular functions related to Internal Hemorrhoid according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium:potassium-exchanging ATPase activity GO:0005391 9.16 ATP4A ATP12A
2 potassium-transporting ATPase activity GO:0008556 8.96 ATP4A ATP12A
3 potassium:proton exchanging ATPase activity GO:0008900 8.62 ATP4A ATP12A

Sources for Internal Hemorrhoid

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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