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MCID: INT059
MIFTS: 35

Internal Hemorrhoid

Categories: Cardiovascular diseases, Gastrointestinal diseases, Skin diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Internal Hemorrhoid

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MalaCards integrated aliases for Internal Hemorrhoid:

Name: Internal Hemorrhoid 12 15
Internal Hemorrhoids 71

Classifications:

MalaCards categories:
Anatomical: Cardiovascular diseases Gastrointestinal diseases Skin diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:9749
ICD9CM 34 455.6
SNOMED-CT 67 82985000
ICD10 32 I84.1 I84.2
UMLS 71 C0041844 C0265034
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Summaries for Internal Hemorrhoid

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Disease Ontology : 12 A hemorrhoid that is located in the rectum.

MalaCards based summary : Internal Hemorrhoid, also known as internal hemorrhoids, is related to dieulafoy lesion and hemorrhoid. An important gene associated with Internal Hemorrhoid is MMP9 (Matrix Metallopeptidase 9), and among its related pathways/superpathways are Syndecan-4-mediated signaling events and IL1 and megakaryocytes in obesity. The drugs Polidocanol and Pharmaceutical Solutions have been mentioned in the context of this disorder. Affiliated tissues include rectum, colon and spinal cord, and related phenotype is digestive/alimentary.

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Related Diseases for Internal Hemorrhoid

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Diseases in the Hemorrhoid family:

Internal Hemorrhoid

Diseases related to Internal Hemorrhoid via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 227)
# Related Disease Score Top Affiliating Genes
1 dieulafoy lesion 29.8 F2 ATP4A ATP12A
2 hemorrhoid 29.4 NOS2 MMP9 F2 CRP ATP4A ATP12A
3 constipation 29.4 NOS2 CRP ATP4A ATP12A
4 mycetoma 10.3 NOS2 MMP9
5 vagus nerve disease 10.3 ATP4A ATP12A
6 scalp dermatosis 10.2 ATP4A ATP12A
7 hemangioma of intra-abdominal structure 10.2 ATP4A ATP12A
8 acquired gastric outlet stenosis 10.2 ATP4A ATP12A
9 lingual goiter 10.2 ATP4A ATP12A
10 displacement of cardia through esophageal hiatus 10.2 ATP4A ATP12A
11 bacterial esophagitis 10.2 ATP4A ATP12A
12 cascade stomach 10.2 ATP4A ATP12A
13 benzylpenicillin allergy 10.2 ATP4A ATP12A
14 afferent loop syndrome 10.2 ATP4A ATP12A
15 cervix erosion 10.2 ATP4A ATP12A
16 angiodysplasia of intestine 10.2 ATP4A ATP12A
17 angiodysplasia 10.2 ATP4A ATP12A
18 granulomatous gastritis 10.2 ATP4A ATP12A
19 laryngeal tuberculosis 10.2 ATP4A ATP12A
20 fungal esophagitis 10.2 ATP4A ATP12A
21 esophagus melanoma 10.2 ATP4A ATP12A
22 cefuroxime allergy 10.2 ATP4A ATP12A
23 gastric gastrinoma 10.2 ATP4A ATP12A
24 pneumatosis cystoides intestinalis 10.2 ATP4A ATP12A
25 chronic laryngitis 10.2 ATP4A ATP12A
26 gastroduodenal crohn's disease 10.2 ATP4A ATP12A
27 polyposis, skin pigmentation, alopecia, and fingernail changes 10.2 ATP4A ATP12A
28 rumination disorder 10.2 ATP4A ATP12A
29 acute laryngitis 10.2 ATP4A ATP12A
30 gastroduodenitis 10.2 ATP4A ATP12A
31 barbiturate abuse 10.2 ATP4A ATP12A
32 duodenal gastrinoma 10.2 ATP4A ATP12A
33 blind loop syndrome 10.2 ATP4A ATP12A
34 polycystic echinococcosis 10.2 ATP4A ATP12A
35 diclofenac allergy 10.2 ATP4A ATP12A
36 lymphocytic gastritis 10.2 ATP4A ATP12A
37 x-linked chondrodysplasia punctata 1 10.2 ATP4A ATP12A
38 pancreatic gastrinoma 10.2 ATP4A ATP12A
39 gastric antral vascular ectasia 10.2 ATP4A ATP12A
40 outlet dysfunction constipation 10.2 ATP4A ATP12A
41 functional diarrhea 10.2 ATP4A ATP12A
42 tropical sprue 10.2 ATP4A ATP12A
43 squamous papillomatosis 10.2 ATP4A ATP12A
44 esophageal tuberculosis 10.2 ATP4A ATP12A
45 eosinophilic gastritis 10.2 ATP4A ATP12A
46 cough variant asthma 10.2 ATP4A ATP12A
47 melon allergy 10.2 ATP4A ATP12A
48 gastritis, familial giant hypertrophic 10.2 ATP4A ATP12A
49 biliary dyskinesia 10.2 ATP4A ATP12A
50 collagenous colitis 10.2 NOS2 MMP9

Graphical network of the top 20 diseases related to Internal Hemorrhoid:



Diseases related to Internal Hemorrhoid
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Symptoms & Phenotypes for Internal Hemorrhoid

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MGI Mouse Phenotypes related to Internal Hemorrhoid:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.02 ATP12A ATP4A F2 MMP9 NOS2
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Drugs & Therapeutics for Internal Hemorrhoid

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Drugs for Internal Hemorrhoid (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Polidocanol Approved Phase 4 9002-92-0
2 Pharmaceutical Solutions Phase 4
3 Sclerosing Solutions Phase 4
4
Lidocaine Approved, Vet_approved Phase 3 137-58-6 3676
5
Prilocaine Approved Phase 3 721-50-6 4906
6 Sodium Channel Blockers Phase 3
7 Anesthetics Phase 3
8 Diuretics, Potassium Sparing Phase 3
9 Anesthetics, Local Phase 3
10 Anti-Arrhythmia Agents Phase 3
11
Hydrocortisone acetate Approved, Vet_approved Phase 2 50-03-3
12
Hydrocortisone Approved, Vet_approved Phase 2 50-23-7 5754
13 Anti-Inflammatory Agents Phase 2
14 Hydrocortisone 17-butyrate 21-propionate Phase 2
15 Hydrocortisone hemisuccinate Phase 2
16 Hydrocortisone-17-butyrate Phase 2
17
Hesperidin Approved, Investigational 520-26-3 53477767
18
Imidacloprid Vet_approved 105827-78-9 86418

Interventional clinical trials:

(show all 13)
# Name Status NCT ID Phase Drugs
1 A Multicenter Prospective Clinical Study of Endoscopic Foam Sclerotherapy for Internal Hemorrhoids Recruiting NCT04398823 Phase 4 Sclerosing foam of Lauromacrogol;Sclersing liqiud of Lauromacrogol
2 Patient Comfort After Stapled Hemorrhoidopexy Long Term Results of a Randomized Controlled Trial Completed NCT01533363 Phase 3
3 Topical Anesthesia Versus Placebo to Decrease Post Procedure Pain in Rubber Band Ligation for the Treatment of Grade I - III Symptomatic Internal Hemorrhoids. A Single Institution, Double Blinded, Placebo Controlled Trial. Completed NCT02130830 Phase 3 Topical 2,5% lidocaine + 2,5% prilocaine gel;Placebo
4 A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Parallel-Treatment Group, Multicenter Efficacy and Safety Study of Intra-Anal Application of Iferanserin (10 mg) as a 0.5% Ointment in Subjects With Symptomatic Internal Hemorrhoids Terminated NCT01355874 Phase 3 Iferanserin;Placebo;Iferanserin + Placebo
5 A Randomized, Double-Blind, Vehicle-Controlled, Multicenter Study to Evaluate Safety and Efficacy of Anucort HC TM (Hydrocortisone Acetate) 25mg Rectal Suppositories in the Treatment of Symptomatic Internal Hemorrhoids Completed NCT01913158 Phase 2 Anucort-HC, 25 Mg Rectal Suppository;Placebo suppository
6 A Randomized, Double-blind, Placebo-controlled, Multicenter, Parallel Group Study of the Safety and Efficacy of Hydrocortisone Acetate Suppositories, 25 mg Compared to Placebo Suppositories in the Treatment of Symptomatic Internal Hemorrhoids Recruiting NCT03335774 Phase 2 Hydrocortisone Acetate Suppository, 25 mg;Placebo (Vehicle) Suppository
7 A Multi Center Clinical Trial of the Efficacy and Safety of Rph With the Simplified Milligan-Morgan Surgery on Treatment of Mixed Hemorrhoids Unknown status NCT02306421
8 Randomized Study Of Endoscopic Band Ligation Versus Bipolar Probe Electrocoagulation Of Bleeding Internal Hemorrhoids Completed NCT00630669
9 Cap-assisted Endoscopic Sclerotherapy for Internal Hemorrhoids and Rectal Prolapse: a Nationwide Multicenter Randomized Controlled Trial Recruiting NCT03917056
10 Long-term Efficacy of Doppler Ligation With Mucopexy in the Treatment of Internal Hemorrhoidal Disease Recruiting NCT04708678
11 Cap-assisted Endoscopic Sclerotherapy for Internal Hemorrhoids and Rectal Prolapse: a National Multi-centre Prospective Cohort Study Not yet recruiting NCT04169152
12 Comparative Study of Band Ligation and Phlebotonic Drug Versus Only Phlebotonic Drug, in Bleeding Internal Hemorrhoids. Not yet recruiting NCT04290351 oral 450 mg diosmin+50 mg hesperidin
13 Evaluation of Distal Esophageal and Cardia Rubber Band Ligation and Mucosectomy in the Treatment of Subjects With Gastroesophageal Reflux Disease Terminated NCT01199679

Search NIH Clinical Center for Internal Hemorrhoid

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Genetic Tests for Internal Hemorrhoid

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Anatomical Context for Internal Hemorrhoid

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The Foundational Model of Anatomy Ontology organs/tissues related to Internal Hemorrhoid:

19
Rectum

MalaCards organs/tissues related to Internal Hemorrhoid:

40
Colon, Spinal Cord
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Publications for Internal Hemorrhoid

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Articles related to Internal Hemorrhoid:

(show top 50) (show all 352)
# Title Authors PMID Year
1
The clinical features of chronic intestinal schistosomiasis-related intestinal lesions. 61
33407185 2021
2
Evaluation of a Minimally Invasive Bipolar Coagulation System for the Treatment of Grade I and II Internal Hemorrhoids. 61
33496474 2021
3
Internal hemorrhoid harboring adenocarcinoma: A case report. 61
33510851 2021
4
Modified procedure for prolapse and hemorrhoids: Lower recurrence, higher satisfaction. 61
33511170 2021
5
Superior rectal artery embolization for bleeding internal hemorrhoids. 61
32712932 2021
6
Tissue selecting technique mega-window stapler combined with anal canal epithelial preservation operation for the treatment of severe prolapsed hemorrhoids: A study protocol for a randomized controlled trial. 61
33157990 2020
7
Assessment of pediatric Crohn's disease activity: validation of the magnetic resonance enterography global score (MEGS) against endoscopic activity score (SES-CD). 61
32458027 2020
8
A Multicenter Prospective Non-Randomized Study Comparing Ferguson Hemorrhoidectomy and Transanal Hemorrhoidal Dearterialization for Prolapsed, Nonincarcerated, Reducible Hemorrhoids: A Study Protocol. 61
33238029 2020
9
Efficacy and safety of sclerotherapy with polidocanol in children with internal hemorrhoids. 61
33045763 2020
10
Giant Gastric Ulcers: An Unusual Culprit. 61
32875528 2020
11
Anorectal diseases in patients with Antiphospholipid syndrome: a cross-sectional study. 61
33028422 2020
12
Efficacy of modified rubber band ligation in the treatment of grade III internal hemorrhoids. 61
33081476 2020
13
Fundamentals of Anorectal Technical Skills: A Concise Surgical Skills Course. 61
32313930 2020
14
Perianal Crohn's Disease. 61
32692067 2020
15
Laparoscopic anterior resection for rectal stenosis caused by ALTA injection for internal hemorrhoids: A case report. 61
32789974 2020
16
A New Classification for Hemorrhoidal Disease: The Creation of the "BPRST" Staging and Its Application in Clinical Practice. 61
32674550 2020
17
Gluteal-fold flap repair of rectovaginal fistula caused by aluminum potassium sulfate hydrate-tannic acid injection for internal hemorrhoids: a case report. 61
32643046 2020
18
Jejunal-Ileal Bypass and its Complications: Case Report and Review of the Literature. 61
32699731 2020
19
Rubber Band Ligation of Hemorrhoids is often a Necessary Complement in the Management of Hemorrhagic Radiation Proctitis. 61
30632450 2020
20
Polidocanol versus phenol in oil injection sclerotherapy in treatment of internal hemorrhoids: A randomized controlled trial. 61
32519957 2020
21
CT colonography has low sensitivity but high specificity in the detection of internal hemorrhoids. 61
32116218 2020
22
The Management of Acute Hemorrhoidal Disease. 61
32223737 2020
23
Network meta-analysis of randomized controlled trials comparing the procedure for prolapse and hemorrhoids, Milligan-Morgan hemorrhoidectomy and tissue-selecting therapy stapler in the treatment of grade III and IV internal hemorrhoids(Meta-analysis). 61
31887419 2020
24
Cap-assisted endoscopic sclerotherapy for internal hemorrhoids: technique protocol and study design for a multi-center randomized controlled trial. 61
32551439 2020
25
[Submucosal laser ablation of internal hemorrhoids]. 61
32271744 2020
26
Video anoscopy: results of routine anal examination during colonoscopies. 61
31723578 2019
27
Endoscopic Sclerotherapy with Aluminum Potassium Sulfate and Tannic Acid: An Effective and Less Invasive Strategy for Internal Hemorrhoids. 61
31722520 2019
28
Effectiveness of Endoscopic Sclerotherapy with Aluminum Potassium Sulfate and Tannic Acid as a Non-Surgical Treatment for Internal Hemorrhoids. 61
31337196 2019
29
Treatment of hemorrhoids: A survey of surgical practice in Australia and New Zealand. 61
31799299 2019
30
Laparoscopic rectal tumor surgery after administration of a new sclerosing therapy (aluminum potassium sulfate and tannic acid injection) for internal hemorrhoids: A report of three cases. 61
30411508 2019
31
Robot-assisted low anterior resection after aluminum potassium sulfate and tannic acid sclerosing therapy for internal hemorrhoids. 61
31664540 2019
32
Hemorrhoid Banding: A Cost-Effectiveness Analysis. 61
31318773 2019
33
Hemorrhoid Energy Therapy for Treatment of Deep Chronic Anal Fissures. 61
31737710 2019
34
Comparison of the effect of Myrtus communis herbal and anti-hemorrhoid ointments on the hemorrhoid symptoms and quality of life in postpartum women with grade I and II internal hemorrhoid: A triple-blinded randomized controlled clinical trial. 61
31433782 2019
35
Piles of Money: "Hemorrhoids" Are a Billion-Dollar Industry. 61
30998519 2019
36
Polidocanol Foam Injected at High Doses with Intravenous Needle: The (Almost) Perfect Treatment of Symptomatic Internal Hemorrhoids. 61
31192285 2019
37
Polidocanol Foam: A Breath of Fresh Air for the Treatment of Internal Hemorrhoids. 61
31192282 2019
38
Pre-operative assessment of internal mucosal rectal prolapse in internal hemorrhoids: technical details and results from a single institution. 61
31125011 2019
39
Pathophysiology of internal hemorrhoids. 61
31040623 2019
40
THD Doppler: A Reliable Surgical Procedure to Treat Hemorrhoids. 61
30888670 2019
41
An Incidental Finding of Anemia: Rectal Adenocarcinoma in a Young Adult. 61
31275778 2019
42
Transanal hemorrhoidal dearterialization (THD) versus stapled hemorrhoidopexy (SH) in treatment of internal hemorrhoids: a systematic review and meta-analysis of randomized clinical trials. 61
30421308 2019
43
Clopidogrel bisulfate (Plavix) does not increase bleeding complications in patients undergoing rubber band ligation for symptomatic hemorrhoids. 61
29936995 2018
44
Hemorrhoids: Diagnosis and Treatment Options. 61
29431977 2018
45
A Randomized Controlled Trial Comparing Laser Intra-Hemorrhoidal Coagulation and Milligan-Morgan Hemorrhoidectomy. 61
27806213 2017
46
Endoscopic treatment of internal hemorrhoids by use of a bipolar system. 61
30182083 2017
47
Comparative clinical study of Apamarga Kshara application, infrared coagulation and Arshohara Vati in the management of Arsha (1st and 2nd degree hemorrhoids). 61
30254391 2017
48
Liver injury after aluminum potassium sulfate and tannic acid treatment of hemorrhoids. 61
28785156 2017
49
[A multicenter, randomized controlled trial of wheat cellulose particles in the treatment of internal hemorrhoids]. 61
28722093 2017
50
Management of internal bleeding piles by ligation and plication followed by Matra Basti - A case report. 61
30254394 2017
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Variations for Internal Hemorrhoid

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Expression for Internal Hemorrhoid

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Search GEO for disease gene expression data for Internal Hemorrhoid.
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Pathways for Internal Hemorrhoid

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Pathways related to Internal Hemorrhoid according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Syndecan-4-mediated signaling events 1
10.45 MMP9 F2
2
IL1 and megakaryocytes in obesity 1
10.02 MMP9 F2
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GO Terms for Internal Hemorrhoid

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Biological processes related to Internal Hemorrhoid according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 potassium ion import across plasma membrane GO:1990573 9.37 ATP4A ATP12A
2 acute-phase response GO:0006953 9.32 F2 CRP
3 cellular sodium ion homeostasis GO:0006883 9.26 ATP4A ATP12A
4 sodium ion export across plasma membrane GO:0036376 9.16 ATP4A ATP12A
5 cellular potassium ion homeostasis GO:0030007 8.96 ATP4A ATP12A
6 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 8.62 ATP4A ATP12A

Molecular functions related to Internal Hemorrhoid according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium:potassium-exchanging ATPase activity GO:0005391 9.16 ATP4A ATP12A
2 potassium-transporting ATPase activity GO:0008556 8.96 ATP4A ATP12A
3 potassium:proton exchanging ATPase activity GO:0008900 8.62 ATP4A ATP12A
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Sources for Internal Hemorrhoid

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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