MCID: INT042
MIFTS: 38

Internuclear Ophthalmoplegia

Categories: Eye diseases, Neuronal diseases

Aliases & Classifications for Internuclear Ophthalmoplegia

MalaCards integrated aliases for Internuclear Ophthalmoplegia:

Name: Internuclear Ophthalmoplegia 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:538
ICD10 33 H51.2
ICD9CM 35 378.86
MeSH 44 D015835
SNOMED-CT 68 49823009
UMLS 73 C0152134

Summaries for Internuclear Ophthalmoplegia

MalaCards based summary : Internuclear Ophthalmoplegia is related to multiple sclerosis and neuromyelitis optica, and has symptoms including ophthalmoplegia, spasm of conjugate gaze and anomalies of divergence. An important gene associated with Internuclear Ophthalmoplegia is AQP4 (Aquaporin 4), and among its related pathways/superpathways are Neuroscience and Spinal Cord Injury. The drugs 4-Aminopyridine and Potassium Channel Blockers have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and testes, and related phenotypes are behavior/neurological and growth/size/body region

Wikipedia : 76 Internuclear ophthalmoplegia (INO) is a disorder of conjugate lateral gaze in which the affected eye... more...

Related Diseases for Internuclear Ophthalmoplegia

Diseases related to Internuclear Ophthalmoplegia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 109)
# Related Disease Score Top Affiliating Genes
1 multiple sclerosis 30.7 AQP4 IFNB1 MBP MOG
2 neuromyelitis optica 30.4 AQP4 HCRT MBP MOG
3 myelitis 30.2 AQP4 MBP MOG
4 optic neuritis 30.2 AQP4 MBP MOG
5 neuritis 30.2 AQP4 MBP MOG
6 temporal arteritis 10.5
7 head injury 10.5
8 exotropia 10.4
9 lupus erythematosus 10.4
10 systemic lupus erythematosus 10.4
11 myasthenia gravis 10.4
12 myasthenia gravis congenital 10.4
13 exophthalmos 10.4
14 supranuclear palsy, progressive, 1 10.3
15 meningitis 10.3
16 supranuclear ocular palsy 10.2
17 central pontine myelinolysis 10.2 AQP4 MBP
18 autoimmune encephalitis 10.2 HCRT LGI1
19 gaucher disease, perinatal lethal 10.2 GBA HEXA
20 allergic encephalomyelitis 10.2 MBP MOG
21 transverse myelitis 10.2 AQP4 MBP
22 traumatic brain injury 10.2 AQP4 MBP
23 childhood disintegrative disease 10.2 HEXA LGI1 MBP
24 strabismus 10.2
25 aceruloplasminemia 10.2
26 ptosis 10.2
27 vasculitis 10.2
28 glioma 10.2
29 neuromyelitis optica spectrum disorder 10.2
30 tuberculous meningitis 10.2
31 obstructive hydrocephalus 10.2 AQP4 NF1
32 narcolepsy 1 10.1 HCRT MOG
33 mannosidosis, beta a, lysosomal 10.1 HEXA MBP
34 panencephalitis, subacute sclerosing 10.1 MBP MOG
35 autoimmune optic neuritis 10.1 AQP4 MBP MOG
36 encephalitis 10.1 AQP4 LGI1 MOG
37 oculomotor nerve paralysis 10.1 KANTR MBP
38 neuroretinitis 10.1 AQP4 IFNB1 MOG
39 third cranial nerve disease 10.1 KANTR MBP
40 autoimmune disease of peripheral nervous system 10.1 HCRT MBP MOG
41 expressive language disorder 10.1 NF1 PSEN1
42 narcolepsy 10.1 AQP4 HCRT MOG
43 tabes dorsalis 10.1 KANTR MBP
44 anterior spinal artery syndrome 10.0 KANTR MBP
45 juvenile pilocytic astrocytoma 10.0 MBP NF1
46 hyperhidrosis, gustatory 10.0 KANTR NF1
47 pernicious anemia 10.0
48 chiari malformation type ii 10.0
49 3-methylglutaconic aciduria, type iii 10.0
50 chronic inflammatory demyelinating polyneuropathy 10.0

Comorbidity relations with Internuclear Ophthalmoplegia via Phenotypic Disease Network (PDN):


Hypertension, Essential

Graphical network of the top 20 diseases related to Internuclear Ophthalmoplegia:



Diseases related to Internuclear Ophthalmoplegia

Symptoms & Phenotypes for Internuclear Ophthalmoplegia

UMLS symptoms related to Internuclear Ophthalmoplegia:


ophthalmoplegia, spasm of conjugate gaze, anomalies of divergence

MGI Mouse Phenotypes related to Internuclear Ophthalmoplegia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.17 AQP4 CD55 GBA HCRT HEXA LGI1
2 growth/size/body region MP:0005378 10.1 AQP4 GBA HCRT HEXA LGI1 MBP
3 hematopoietic system MP:0005397 10.07 AQP4 CD55 CXCR5 GBA GKN2 IFNB1
4 homeostasis/metabolism MP:0005376 10.06 AQP4 GBA GKN2 HCRT HEXA IFNB1
5 immune system MP:0005387 10 AQP4 CD55 CXCR5 GBA GKN2 IFNB1
6 nervous system MP:0003631 9.85 AQP4 GBA HCRT HEXA IFNB1 LGI1
7 normal MP:0002873 9.56 CXCR5 GBA IFNB1 MBP NF1 OMG
8 vision/eye MP:0005391 9.23 AQP4 HEXA LGI1 MBP MOG NF1

Drugs & Therapeutics for Internuclear Ophthalmoplegia

Drugs for Internuclear Ophthalmoplegia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
4-Aminopyridine Approved Phase 2 504-24-5 1727
2 Potassium Channel Blockers Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study and Treatment of Visual Dysfunction and Motor Fatigue in Multiple Sclerosis Recruiting NCT02391961 Phase 2 Dalfampridine;Placebo

Search NIH Clinical Center for Internuclear Ophthalmoplegia

Genetic Tests for Internuclear Ophthalmoplegia

Anatomical Context for Internuclear Ophthalmoplegia

MalaCards organs/tissues related to Internuclear Ophthalmoplegia:

41
Eye, Brain, Testes, Pons, Spinal Cord, Thymus

Publications for Internuclear Ophthalmoplegia

Articles related to Internuclear Ophthalmoplegia:

(show top 50) (show all 290)
# Title Authors Year
1
Uveitis and internuclear ophthalmoplegia as ocular manifestations of sarcoidosis. ( 29942190 )
2018
2
Teaching Video NeuroImages: Pulsatile proptosis and wall-eyed bilateral internuclear ophthalmoplegia. ( 29686128 )
2018
3
Editors' note: Impaired vestibular responses in internuclear ophthalmoplegia: Association and dissociation. ( 30150270 )
2018
4
Reader response: Impaired vestibular responses in internuclear ophthalmoplegia: Association and dissociation. ( 30150271 )
2018
5
Author response: Impaired vestibular responses in internuclear ophthalmoplegia: Association and dissociation. ( 30150272 )
2018
6
Wall-eyed Bilateral Internuclear Ophthalmoplegia (WEBINO) in a Patient With Idiopathic Intracranial Hypertension. ( 30169368 )
2018
7
Determining the Etiology of Internuclear Ophthalmoplegia in a Patient with a Cardiac Pacemaker and Complex Neurological Presentation. ( 30198234 )
2018
8
Bilateral pseudo-internuclear ophthalmoplegia in a patient with myasthenia gravis. ( 30294700 )
2018
9
Editors' note: Teaching Video NeuroImages: Pulsatile proptosis and wall-eyed bilateral internuclear ophthalmoplegia. ( 30397041 )
2018
10
Reader response: Teaching Video NeuroImages: Pulsatile proptosis and wall-eyed bilateral internuclear ophthalmoplegia. ( 30397042 )
2018
11
Author response: Teaching Video NeuroImages: Pulsatile proptosis and wall-eyed bilateral internuclear ophthalmoplegia. ( 30397043 )
2018
12
Teaching Video NeuroImages: Pulsatile proptosis and wall-eyed bilateral internuclear ophthalmoplegia. ( 30397047 )
2018
13
Nine Syndrome: Case Report and Review of Clinical Signs in Internuclear Ophthalmoplegia. ( 30532368 )
2018
14
Orbital metastasis mimicking internuclear ophthalmoplegia: A case report and review. ( 28774543 )
2017
15
Preferential Impairment of the Contralesional Posterior Semicircular Canal in Internuclear Ophthalmoplegia. ( 29018402 )
2017
16
Bilateral internuclear ophthalmoplegia following head trauma. ( 28440256 )
2017
17
Isolated Internuclear Ophthalmoplegia After Massive Supratentorial Epidural Hematoma: A Case Report and Review of the Literature. ( 28143728 )
2017
18
Post-operative unilateral internuclear ophthalmoplegia following basilar pneumocephalus after resection of C1 intradural extramedullary tumor. ( 28558345 )
2017
19
A rare cause for visual symptoms in multiple sclerosis: posterior internuclear ophthalmoplegia of Lutz, a historical misnomer. ( 28194531 )
2017
20
Isolated bilateral internuclear ophthalmoplegia due to lacunar infarction. ( 29170848 )
2017
21
Internuclear Ophthalmoplegia ( 28722999 )
2017
22
Saccadic hypermetria on abduction of the ipsilesional eye in internuclear ophthalmoplegia. ( 28431591 )
2017
23
Impaired vestibular responses in internuclear ophthalmoplegia: Association and dissociation. ( 29142084 )
2017
24
Internuclear Ophthalmoplegia Secondary to Cocaine Abuse. ( 28265477 )
2017
25
Can Wernekink commissure syndrome and wall-eyed bilateral internuclear ophthalmoplegia be ascribed to neuromyelitis optica spectrum disorder? ( 28681309 )
2017
26
Paramedian pons infarction with wall-eye monocular internuclear ophthalmoplegia syndrome. ( 26944331 )
2016
27
Internuclear ophthalmoplegia. ( 27927777 )
2016
28
A Case of Traumatic Unilateral Internuclear Ophthalmoplegia: Clinical Significance of Susceptibility-Weighted Imaging. ( 27857923 )
2016
29
Bilateral Internuclear Ophthalmoplegia as a Presenting Manifestation of Primary SjAPgren's Syndrome. ( 27928415 )
2016
30
Unilateral internuclear ophthalmoplegia, strabismus and transient torsional nystagmus in focal pontine infarction. ( 27448548 )
2016
31
Visualisation of the medial longitudinal fasciculus using fibre tractography in multiple sclerosis patients with internuclear ophthalmoplegia. ( 26787313 )
2016
32
Internuclear ophthalmoplegia plus ataxia indicates a dorsomedial tegmental lesion at the pontomesencephalic junction. ( 26995360 )
2016
33
Pathways Linked to Internuclear Ophthalmoplegia on Diffusion-Tensor Imaging in a Case with Midbrain Infarction. ( 27567293 )
2016
34
Unilateral internuclear ophthalmoplegia with upbeat nystagmus from ischemic origin: evidence for the paramedian tract neurons as a vertical neural integrator? ( 26550407 )
2015
35
Wall-eyed bilateral internuclear ophthalmoplegia. ( 26053827 )
2015
36
Internuclear Ophthalmoplegia Associated with Anti-TNFI+ Medication. ( 25790247 )
2015
37
Gaze palsy and exotropia in internuclear ophthalmoplegia. ( 25911021 )
2015
38
Large basilar tip aneurysm causing anterior internuclear ophthalmoplegia. ( 25670869 )
2015
39
Unilateral Internuclear Ophthalmoplegia as an Isolated Presentation of Metastatic Melanoma. ( 25232840 )
2014
40
Vertical gaze-evoked nystagmus and internuclear ophthalmoplegia as sole manifestations in paramedian pontine infarction. ( 24770935 )
2014
41
Wall-eyed bilateral internuclear ophthalmoplegia: review of pathogenesis, diagnosis, prognosis and management. ( 25308307 )
2014
42
Brainstem Infarction with Wall-eyed Bilateral Internuclear Ophthalmoplegia Syndrome and Vertical One-and-a-Half Syndrome. ( 24424330 )
2014
43
Bilateral ptosis with wall-eyed bilateral internuclear ophthalmoplegia and vertical gaze paralysis. ( 24870222 )
2014
44
Periprocedural stroke presenting as isolated unilateral internuclear ophthalmoplegia. ( 25114281 )
2014
45
Diagnostic Efficacy of Conventional MRI Pulse Sequences in the Detection of Lesions Causing Internuclear Ophthalmoplegia in Multiple Sclerosis Patients. ( 24599322 )
2014
46
Pontine infarction responsible for wall-eyed bilateral internuclear ophthalmoplegia syndrome. ( 29443142 )
2014
47
Jerky seesaw nystagmus with internuclear ophthalmoplegia as the presenting finding in systemic lupus erythematosus. ( 25455550 )
2014
48
Pediatric internuclear ophthalmoplegia. ( 23470988 )
2013
49
An unusual aetiology for internuclear ophthalmoplegia. ( 23737577 )
2013
50
Bilateral internuclear ophthalmoplegia associated with pediatric brain tumor progression: a case series and review of the literature. ( 24048548 )
2013

Variations for Internuclear Ophthalmoplegia

Expression for Internuclear Ophthalmoplegia

Search GEO for disease gene expression data for Internuclear Ophthalmoplegia.

Pathways for Internuclear Ophthalmoplegia

Pathways related to Internuclear Ophthalmoplegia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.46 HCRT MBP NF1 PSEN1
2 11.21 AQP4 MBP OMG
3 10.41 GBA HEXA

GO Terms for Internuclear Ophthalmoplegia

Biological processes related to Internuclear Ophthalmoplegia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cytosolic calcium ion concentration GO:0007204 9.43 CD55 CXCR5 HCRT
2 T cell activation involved in immune response GO:0002286 9.16 IFNB1 PSEN1
3 negative regulation of axonogenesis GO:0050771 8.96 OMG PSEN1
4 skin morphogenesis GO:0043589 8.62 GBA PSEN1

Sources for Internuclear Ophthalmoplegia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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