MCID: INT042
MIFTS: 36

Internuclear Ophthalmoplegia

Categories: Eye diseases, Neuronal diseases

Aliases & Classifications for Internuclear Ophthalmoplegia

MalaCards integrated aliases for Internuclear Ophthalmoplegia:

Name: Internuclear Ophthalmoplegia 12 15 72 33

Classifications:



External Ids:

Disease Ontology 12 DOID:538
ICD9CM 35 378.86
MeSH 44 D015835
SNOMED-CT 68 49823009
ICD10 33 H51.2
UMLS 72 C0152134

Summaries for Internuclear Ophthalmoplegia

MalaCards based summary : Internuclear Ophthalmoplegia is related to transverse myelitis and multiple sclerosis, and has symptoms including ophthalmoplegia, spasm of conjugate gaze and anomalies of divergence. An important gene associated with Internuclear Ophthalmoplegia is AQP4 (Aquaporin 4), and among its related pathways/superpathways are Neuroscience and Spinal Cord Injury. Affiliated tissues include eye, brain and pons, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : 75 Internuclear ophthalmoplegia (INO) is a disorder of conjugate lateral gaze in which the affected eye... more...

Related Diseases for Internuclear Ophthalmoplegia

Diseases related to Internuclear Ophthalmoplegia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 168)
# Related Disease Score Top Affiliating Genes
1 transverse myelitis 30.7 MBP AQP4
2 multiple sclerosis 30.7 MOG MBP IFNB1 AQP4
3 myelitis 30.7 MOG MBP AQP4
4 neuritis 30.6 MOG MBP AQP4
5 optic neuritis 30.3 MOG MBP AQP4
6 traumatic brain injury 30.3 MBP AQP4
7 neuromyelitis optica 30.3 MOG MBP HCRT AQP4
8 demyelinating disease 30.3 MOG MBP IFNB1 AQP4
9 encephalitis 30.3 MOG LGI1 AQP4
10 kearns-sayre syndrome 11.3
11 pathologic nystagmus 10.9
12 alternating exotropia 10.7
13 exotropia 10.7
14 head injury 10.6
15 ataxia and polyneuropathy, adult-onset 10.6
16 dissociated nystagmus 10.5
17 supranuclear ocular palsy 10.5
18 myasthenia gravis 10.5
19 vasculitis 10.5
20 lupus erythematosus 10.5
21 systemic lupus erythematosus 10.5
22 ptosis 10.4
23 central pontine myelinolysis 10.4 MBP AQP4
24 hydrocephalus 10.4
25 exophthalmos 10.4
26 meningitis 10.4
27 congenital hydrocephalus 10.4
28 childhood disintegrative disease 10.4 MBP LGI1
29 chiari malformation type ii 10.4
30 supranuclear palsy, progressive, 1 10.4
31 vascular disease 10.4
32 cerebrovascular disease 10.4
33 chiari malformation 10.4
34 allergic encephalomyelitis 10.3 MOG MBP
35 autoimmune encephalitis 10.3 LGI1 HCRT
36 stroke, ischemic 10.3
37 aceruloplasminemia 10.3
38 horner's syndrome 10.3
39 facial paralysis 10.3
40 brain stem infarction 10.3
41 tuberculous meningitis 10.3
42 aneurysm 10.3
43 headache 10.3
44 strabismus 10.2
45 ocular motor apraxia 10.2
46 cryptococcal meningitis 10.2
47 cysticercosis 10.2
48 hemiplegia 10.2
49 visual epilepsy 10.2
50 polyneuropathy 10.2

Comorbidity relations with Internuclear Ophthalmoplegia via Phenotypic Disease Network (PDN):


Hypertension, Essential

Graphical network of the top 20 diseases related to Internuclear Ophthalmoplegia:



Diseases related to Internuclear Ophthalmoplegia

Symptoms & Phenotypes for Internuclear Ophthalmoplegia

UMLS symptoms related to Internuclear Ophthalmoplegia:


ophthalmoplegia, spasm of conjugate gaze, anomalies of divergence

GenomeRNAi Phenotypes related to Internuclear Ophthalmoplegia according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00221-A-1 9.83 NF1
2 Decreased viability GR00221-A-2 9.83 BMP2K NF1 TTN
3 Decreased viability GR00221-A-4 9.83 BMP2K NF1 SRPK2 TTN
4 Decreased viability GR00301-A 9.83 BMP2K
5 Decreased viability GR00342-S-1 9.83 TTN
6 Decreased viability GR00342-S-3 9.83 TTN
7 Decreased viability GR00402-S-2 9.83 BMP2K NF1 SRPK2 TTN
8 Increased transferrin (TF) endocytosis GR00363-A 9.32 AQP4 BMP2K CD55 CXCR5 GKN2 LGI1

MGI Mouse Phenotypes related to Internuclear Ophthalmoplegia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.97 AQP4 CD55 HCRT LGI1 MBP MOG
2 hematopoietic system MP:0005397 9.96 AQP4 CD55 CXCR5 GKN2 IFNB1 MBP
3 immune system MP:0005387 9.85 AQP4 CXCR5 GKN2 IFNB1 MBP MOG
4 normal MP:0002873 9.56 CXCR5 IFNB1 MBP NF1 OMG PSEN1
5 vision/eye MP:0005391 9.23 AQP4 BMP2K LGI1 MBP MOG NF1

Drugs & Therapeutics for Internuclear Ophthalmoplegia

Search Clinical Trials , NIH Clinical Center for Internuclear Ophthalmoplegia

Genetic Tests for Internuclear Ophthalmoplegia

Anatomical Context for Internuclear Ophthalmoplegia

MalaCards organs/tissues related to Internuclear Ophthalmoplegia:

41
Eye, Brain, Pons, Testes, Heart, Kidney, Cerebellum

Publications for Internuclear Ophthalmoplegia

Articles related to Internuclear Ophthalmoplegia:

(show top 50) (show all 599)
# Title Authors PMID Year
1
Fisher one-and-a-half syndrome due to a bulb protuberance cavernoma. 38
30455115 2019
2
Diagnosing and quantifying a common deficit in multiple sclerosis: Internuclear ophthalmoplegia. 38
31004067 2019
3
Ocular manifestations in patients with cerebrovascular accidents in India: a cross-sectional observational study. 38
31129750 2019
4
Brainstem stroke caused by left atrial cardiac papillary fibroelastoma: an increasingly recognized rare cause of stroke. 38
30927617 2019
5
Torsional internuclear ophthalmoplegia in acute ischemic stroke. 38
31041134 2019
6
Acute hypertensive uveitis as the first presentation of multiple sclerosis. 38
30574934 2019
7
Bilateral Internuclear Ophthalmoplegia in a Young Woman with Vertebral Artery Dissection. 38
31293990 2019
8
Bilateral pseudo-internuclear ophthalmoplegia in a patient with myasthenia gravis. 38
30294700 2018
9
Orbital Metastasis From Urothelial Carcinoma: A Comprehensive Literature Review. 38
30489454 2018
10
Teaching Video NeuroImages: Pulsatile proptosis and wall-eyed bilateral internuclear ophthalmoplegia. 38
30397047 2018
11
Reader response: Teaching Video NeuroImages: Pulsatile proptosis and wall-eyed bilateral internuclear ophthalmoplegia. 38
30397042 2018
12
Author response: Teaching Video NeuroImages: Pulsatile proptosis and wall-eyed bilateral internuclear ophthalmoplegia. 38
30397043 2018
13
Editors' note: Teaching Video NeuroImages: Pulsatile proptosis and wall-eyed bilateral internuclear ophthalmoplegia. 38
30397041 2018
14
Nine Syndrome: Case Report and Review of Clinical Signs in Internuclear Ophthalmoplegia. 38
30532368 2018
15
Determining the Etiology of Internuclear Ophthalmoplegia in a Patient with a Cardiac Pacemaker and Complex Neurological Presentation. 38
30198234 2018
16
"Eight and a half" and "nine syndrome" rare presentation of pontine lesions; case reports and review of literature. 38
31210904 2018
17
Wall-eyed Bilateral Internuclear Ophthalmoplegia (WEBINO) in a Patient With Idiopathic Intracranial Hypertension. 38
30169368 2018
18
Editors' note: Impaired vestibular responses in internuclear ophthalmoplegia: Association and dissociation. 38
30150270 2018
19
Reader response: Impaired vestibular responses in internuclear ophthalmoplegia: Association and dissociation. 38
30150271 2018
20
Author response: Impaired vestibular responses in internuclear ophthalmoplegia: Association and dissociation. 38
30150272 2018
21
Transient trochlear nerve palsy following percutaneous angioplasty. 38
29398228 2018
22
Wernekink commissure syndrome with palatal myoclonus at onset: a case report and review of the literature. 38
29712567 2018
23
Teaching Video NeuroImages: Pulsatile proptosis and wall-eyed bilateral internuclear ophthalmoplegia. 38
29686128 2018
24
Isolated bilateral internuclear ophthalmoplegia due to lacunar infarction. 38
29170848 2018
25
Uveitis and internuclear ophthalmoplegia as ocular manifestations of sarcoidosis. 38
29942190 2018
26
Eye Movement Abnormalities in Multiple Sclerosis: Pathogenesis, Modeling, and Treatment. 38
29467711 2018
27
Eight-and-a-half syndrome: a rare potentially life-threatening disease. 38
29977730 2018
28
Case report of a patient with 'one-and-a-half plus syndrome: nine syndrome'. 38
29383261 2018
29
One-and-a-half syndrome with its spectrum disorders. 38
29312874 2017
30
Impaired vestibular responses in internuclear ophthalmoplegia: Association and dissociation. 38
29142084 2017
31
Isolated INO as a presentation of midbrain paramedian area lacunar infarction in patients with diabetes. 38
28869134 2017
32
Can Wernekink commissure syndrome and wall-eyed bilateral internuclear ophthalmoplegia be ascribed to neuromyelitis optica spectrum disorder? 38
28681309 2017
33
Vestibulo-ocular reflex deficits with medial longitudinal fasciculus lesions. 38
28879396 2017
34
Neurological Complications Associated With Anti-Programmed Death 1 (PD-1) Antibodies. 38
28873125 2017
35
Ocular Motor Manifestations of Multiple Sclerosis. 38
28410279 2017
36
Botulinum Toxin Treatment in Multiple Sclerosis-a Review. 38
28819801 2017
37
Orbital metastasis mimicking internuclear ophthalmoplegia: A case report and review. 38
28774543 2017
38
Post-operative unilateral internuclear ophthalmoplegia following basilar pneumocephalus after resection of C1 intradural extramedullary tumor. 38
28558345 2017
39
One and a half syndrome following penetrating head injury: Case report. 38
28347678 2017
40
Saccadic hypermetria on abduction of the ipsilesional eye in internuclear ophthalmoplegia. 38
28431591 2017
41
Isolated Internuclear Ophthalmoplegia After Massive Supratentorial Epidural Hematoma: A Case Report and Review of the Literature. 38
28143728 2017
42
Demographic and clinical profile of Multiple Sclerosis in Kashmir: A short report. 38
28427689 2017
43
Internuclear ophthalmoplegia. 38
27927777 2017
44
Bilateral internuclear ophthalmoplegia following head trauma. 38
28440256 2017
45
A rare cause for visual symptoms in multiple sclerosis: posterior internuclear ophthalmoplegia of Lutz, a historical misnomer. 38
28194531 2017
46
Transposition surgery for WEBINO. 38
27099196 2017
47
Wernekink Commissure Syndrome Secondary to Bilateral Caudal Paramedian Midbrain Infarction Presenting with a Unique "Heart or V" Appearance Sign: Case Report and Review of the Literature. 38
28824533 2017
48
Preferential Impairment of the Contralesional Posterior Semicircular Canal in Internuclear Ophthalmoplegia. 38
29018402 2017
49
Internuclear Ophthalmoplegia Secondary to Cocaine Abuse. 38
28265477 2017
50
Pathways Linked to Internuclear Ophthalmoplegia on Diffusion-Tensor Imaging in a Case with Midbrain Infarction. 38
27567293 2016

Variations for Internuclear Ophthalmoplegia

Expression for Internuclear Ophthalmoplegia

Search GEO for disease gene expression data for Internuclear Ophthalmoplegia.

Pathways for Internuclear Ophthalmoplegia

Pathways related to Internuclear Ophthalmoplegia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.46 PSEN1 NF1 MBP HCRT
2 11.21 OMG MBP AQP4

GO Terms for Internuclear Ophthalmoplegia

Biological processes related to Internuclear Ophthalmoplegia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cytosolic calcium ion concentration GO:0007204 9.33 HCRT CXCR5 CD55
2 T cell activation involved in immune response GO:0002286 8.96 PSEN1 IFNB1
3 negative regulation of axonogenesis GO:0050771 8.62 PSEN1 OMG

Sources for Internuclear Ophthalmoplegia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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