MCID: INT042
MIFTS: 30

Internuclear Ophthalmoplegia

Categories: Eye diseases, Neuronal diseases

Aliases & Classifications for Internuclear Ophthalmoplegia

MalaCards integrated aliases for Internuclear Ophthalmoplegia:

Name: Internuclear Ophthalmoplegia 12 15 71 32

Classifications:



External Ids:

Disease Ontology 12 DOID:538
ICD9CM 34 378.86
MeSH 43 D015835
SNOMED-CT 67 49823009
ICD10 32 H51.2
UMLS 71 C0152134

Summaries for Internuclear Ophthalmoplegia

MalaCards based summary : Internuclear Ophthalmoplegia is related to exotropia and dissociated nystagmus, and has symptoms including ophthalmoplegia, spasm of conjugate gaze and anomalies of divergence. An important gene associated with Internuclear Ophthalmoplegia is AQP4 (Aquaporin 4). Affiliated tissues include eye, brain and spinal cord.

Wikipedia : 74 Internuclear ophthalmoplegia (INO) is a disorder of conjugate lateral gaze in which the affected eye... more...

Related Diseases for Internuclear Ophthalmoplegia

Diseases related to Internuclear Ophthalmoplegia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 191)
# Related Disease Score Top Affiliating Genes
1 exotropia 31.4 NT5C3A JRK
2 dissociated nystagmus 31.0 NT5C3A JRK HECTD4
3 brain stem infarction 30.8 SRPK2 HECTD4
4 strabismus 30.1 NT5C3A JRK CACNA1A
5 optic neuritis 30.0 MOG AQP4
6 intracranial hypertension 30.0 CACNA1A AQP4
7 neuromyelitis optica 29.9 MOG AQP4
8 hemiplegia 29.7 HECTD4 CACNA1A
9 myelitis 29.7 MOG IFNB1 AQP4
10 demyelinating disease 29.6 MOG IFNB1 AQP4
11 encephalitis 29.2 MOG LGI1 AQP4
12 kearns-sayre syndrome 11.3
13 pathologic nystagmus 11.0
14 alternating exotropia 10.7
15 head injury 10.6
16 ataxia and polyneuropathy, adult-onset 10.6
17 multiple sclerosis 10.6
18 myasthenia gravis 10.6
19 vasculitis 10.5
20 lupus erythematosus 10.5
21 systemic lupus erythematosus 10.5
22 ptosis 10.4
23 supranuclear palsy, progressive, 1 10.4
24 hydrocephalus 10.4
25 meningitis 10.4
26 chiari malformation type ii 10.3
27 facial paralysis 10.3
28 vascular disease 10.3
29 cerebrovascular disease 10.3
30 exophthalmos 10.3
31 chiari malformation 10.3
32 abducens nerve disease 10.3 NT5C3A AQP4
33 stroke, ischemic 10.3
34 aceruloplasminemia 10.3
35 horner's syndrome 10.3
36 mechanical strabismus 10.3
37 pontine hemorrhage 10.3
38 tuberculous meningitis 10.3
39 mixed cerebral palsy 10.2 JRK HECTD4
40 miller fisher syndrome 10.2 NT5C3A HECTD4
41 autoimmune disease 10.2
42 ocular motor apraxia 10.2
43 cryptococcal meningitis 10.2
44 cysticercosis 10.2
45 visual epilepsy 10.2
46 polyneuropathy 10.2
47 neuritis 10.2
48 wernicke encephalopathy 10.2
49 astrocytoma 10.2
50 syphilis 10.2

Comorbidity relations with Internuclear Ophthalmoplegia via Phenotypic Disease Network (PDN):


Hypertension, Essential

Graphical network of the top 20 diseases related to Internuclear Ophthalmoplegia:



Diseases related to Internuclear Ophthalmoplegia

Symptoms & Phenotypes for Internuclear Ophthalmoplegia

UMLS symptoms related to Internuclear Ophthalmoplegia:


ophthalmoplegia, spasm of conjugate gaze, anomalies of divergence

Drugs & Therapeutics for Internuclear Ophthalmoplegia

Search Clinical Trials , NIH Clinical Center for Internuclear Ophthalmoplegia

Genetic Tests for Internuclear Ophthalmoplegia

Anatomical Context for Internuclear Ophthalmoplegia

MalaCards organs/tissues related to Internuclear Ophthalmoplegia:

40
Eye, Brain, Spinal Cord, Pons, Thyroid, Testes, Cerebellum

Publications for Internuclear Ophthalmoplegia

Articles related to Internuclear Ophthalmoplegia:

(show top 50) (show all 614)
# Title Authors PMID Year
1
Internuclear Ophthalmoplegia as the Presenting Sign of Giant Cell Arteritis. 61
31609838 2020
2
Remote Pontine Hemorrhage After Left Frontal Lobe Meningioma Resection Presenting as Bilateral Internuclear Ophthalmoplegia. 61
31972712 2020
3
Video-oculography in multiple sclerosis: Links between oculomotor disorders and brain magnetic resonance imaging (MRI). 61
32028119 2020
4
Wernekink commissure syndrome secondary to a rare 'V'-shaped pure midbrain infarction: a case report and review of the literature. 61
31858860 2020
5
Paroxysmal Adduction After Internuclear Ophthalmoplegia. 61
31834196 2019
6
Ocular manifestations in patients with cerebrovascular accidents in India: a cross-sectional observational study. 61
31129750 2019
7
Seesaw nystagmus with internuclear ophthalmoplegia from bilateral dorsomedial pons and left thalamus infarction: a case report. 61
31779712 2019
8
Trochlear nerve palsy and contralateral internuclear ophthalmoplegia: an unusual crossed syndrome. 61
31769084 2019
9
Sixteen-and-a-half syndrome with metastatic pons tumor: A case report. 61
31764815 2019
10
Persistent trigeminal artery in a patient with posterior circulation stroke treated with rt-PA: case report. 61
31656167 2019
11
Rapid same-day resolution of internuclear ophthalmoplegia in Wernicke encephalopathy following parenteral high dose thiamine. 61
31712022 2019
12
Myasthenia Gravis Presenting as Lutz Posterior Internuclear Ophthalmoplegia. 61
31528190 2019
13
Caudal paramedian midbrain infarction: a clinical study of imaging, clinical features and stroke mechanisms. 61
31456122 2019
14
Fisher one-and-a-half syndrome due to a bulb protuberance cavernoma. 61
30455115 2019
15
Wall-Eyed Monocular Internuclear Ophthalmoplegia (WEMINO) and Millard-Gubler Syndromes in a Patient with Isolated Pontine Infarction: Topographic, Oculomotor, and Radiological Analysis of Two Very Uncommon Conditions. 61
31543808 2019
16
Progressive Supranuclear Palsy with Wall-Eyed Bilateral Internuclear Ophthalmoplegia Syndrome: Authors' Second Case. 61
31543804 2019
17
Brainstem stroke caused by left atrial cardiac papillary fibroelastoma: an increasingly recognized rare cause of stroke. 61
30927617 2019
18
Diagnosing and quantifying a common deficit in multiple sclerosis: Internuclear ophthalmoplegia. 61
31004067 2019
19
Orbital Metastasis From Urothelial Carcinoma: A Comprehensive Literature Review. 61
30489454 2019
20
Torsional internuclear ophthalmoplegia in acute ischemic stroke. 61
31041134 2019
21
Myasthenia Gravis With Reversible Pyramidal Tract Damage and Pseudo Internuclear Ophthalmoplegia. A Case Report and Literature Review. 61
31551914 2019
22
Bilateral Internuclear Ophthalmoplegia in a Young Woman with Vertebral Artery Dissection. 61
31293990 2019
23
Acute hypertensive uveitis as the first presentation of multiple sclerosis. 61
30574934 2019
24
When "looks" can be deceiving - Internuclear ophthalmoplegia after mild traumatic brain injury: Case report and literature review. 61
31539826 2019
25
Reversible Progressive Multiple Cranial Nerve Paresis in the Isolated Fourth Ventricle following Placement of Fourth Ventricle Shunt: Case Report and Review of the Literature. 61
31597144 2019
26
Bilateral pseudo-internuclear ophthalmoplegia in a patient with myasthenia gravis. 61
30294700 2018
27
Reader response: Teaching Video NeuroImages: Pulsatile proptosis and wall-eyed bilateral internuclear ophthalmoplegia. 61
30397042 2018
28
Author response: Teaching Video NeuroImages: Pulsatile proptosis and wall-eyed bilateral internuclear ophthalmoplegia. 61
30397043 2018
29
Teaching Video NeuroImages: Pulsatile proptosis and wall-eyed bilateral internuclear ophthalmoplegia. 61
30397047 2018
30
Nine Syndrome: Case Report and Review of Clinical Signs in Internuclear Ophthalmoplegia. 61
30532368 2018
31
Determining the Etiology of Internuclear Ophthalmoplegia in a Patient with a Cardiac Pacemaker and Complex Neurological Presentation. 61
30198234 2018
32
"Eight and a half" and "nine syndrome" rare presentation of pontine lesions; case reports and review of literature. 61
31210904 2018
33
Wall-eyed Bilateral Internuclear Ophthalmoplegia (WEBINO) in a Patient With Idiopathic Intracranial Hypertension. 61
30169368 2018
34
Reader response: Impaired vestibular responses in internuclear ophthalmoplegia: Association and dissociation. 61
30150271 2018
35
Author response: Impaired vestibular responses in internuclear ophthalmoplegia: Association and dissociation. 61
30150272 2018
36
Transient trochlear nerve palsy following percutaneous angioplasty. 61
29398228 2018
37
Wernekink commissure syndrome with palatal myoclonus at onset: a case report and review of the literature. 61
29712567 2018
38
Isolated bilateral internuclear ophthalmoplegia due to lacunar infarction. 61
29170848 2018
39
Teaching Video NeuroImages: Pulsatile proptosis and wall-eyed bilateral internuclear ophthalmoplegia. 61
29686128 2018
40
Uveitis and internuclear ophthalmoplegia as ocular manifestations of sarcoidosis. 61
29942190 2018
41
Eye Movement Abnormalities in Multiple Sclerosis: Pathogenesis, Modeling, and Treatment. 61
29467711 2018
42
Eight-and-a-half syndrome: a rare potentially life-threatening disease. 61
29977730 2018
43
Case report of a patient with 'one-and-a-half plus syndrome: nine syndrome'. 61
29383261 2018
44
One-and-a-half syndrome with its spectrum disorders. 61
29312874 2017
45
Impaired vestibular responses in internuclear ophthalmoplegia: Association and dissociation. 61
29142084 2017
46
Isolated INO as a presentation of midbrain paramedian area lacunar infarction in patients with diabetes. 61
28869134 2017
47
Can Wernekink commissure syndrome and wall-eyed bilateral internuclear ophthalmoplegia be ascribed to neuromyelitis optica spectrum disorder? 61
28681309 2017
48
Vestibulo-ocular reflex deficits with medial longitudinal fasciculus lesions. 61
28879396 2017
49
Neurological Complications Associated With Anti-Programmed Death 1 (PD-1) Antibodies. 61
28873125 2017
50
Ocular Motor Manifestations of Multiple Sclerosis. 61
28410279 2017

Variations for Internuclear Ophthalmoplegia

Expression for Internuclear Ophthalmoplegia

Search GEO for disease gene expression data for Internuclear Ophthalmoplegia.

Pathways for Internuclear Ophthalmoplegia

GO Terms for Internuclear Ophthalmoplegia

Biological processes related to Internuclear Ophthalmoplegia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 glucose metabolic process GO:0006006 8.96 HECTD4 GALM
2 negative regulation of viral genome replication GO:0045071 8.62 SRPK2 IFNB1

Sources for Internuclear Ophthalmoplegia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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