MCID: INT042
MIFTS: 38

Internuclear Ophthalmoplegia

Categories: Eye diseases, Neuronal diseases

Aliases & Classifications for Internuclear Ophthalmoplegia

MalaCards integrated aliases for Internuclear Ophthalmoplegia:

Name: Internuclear Ophthalmoplegia 12 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:538
ICD9CM 36 378.86
MeSH 45 D015835
SNOMED-CT 69 49823009
ICD10 34 H51.2
UMLS 74 C0152134

Summaries for Internuclear Ophthalmoplegia

MalaCards based summary : Internuclear Ophthalmoplegia is related to multiple sclerosis and neuromyelitis optica, and has symptoms including ophthalmoplegia, spasm of conjugate gaze and anomalies of divergence. An important gene associated with Internuclear Ophthalmoplegia is AQP4 (Aquaporin 4), and among its related pathways/superpathways are Neuroscience and Spinal Cord Injury. The drugs 4-Aminopyridine and Potassium Channel Blockers have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and testes, and related phenotypes are behavior/neurological and hematopoietic system

Wikipedia : 77 Internuclear ophthalmoplegia (INO) is a disorder of conjugate lateral gaze in which the affected eye... more...

Related Diseases for Internuclear Ophthalmoplegia

Diseases related to Internuclear Ophthalmoplegia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 114)
# Related Disease Score Top Affiliating Genes
1 multiple sclerosis 30.8 AQP4 IFNB1 MBP MOG
2 neuromyelitis optica 30.4 AQP4 HCRT MBP MOG
3 myelitis 30.3 AQP4 MBP MOG
4 optic neuritis 30.3 AQP4 MBP MOG
5 neuritis 30.3 AQP4 MBP MOG
6 pathologic nystagmus 10.7
7 head injury 10.5
8 alternating exotropia 10.4
9 exotropia 10.4
10 lupus erythematosus 10.4
11 systemic lupus erythematosus 10.4
12 myasthenia gravis 10.4
13 myasthenia gravis congenital 10.4
14 exophthalmos 10.4
15 central pontine myelinolysis 10.3 AQP4 MBP
16 supranuclear palsy, progressive, 1 10.3
17 meningitis 10.3
18 childhood disintegrative disease 10.3 LGI1 MBP
19 autoimmune encephalitis 10.3 HCRT LGI1
20 allergic encephalomyelitis 10.3 MBP MOG
21 neuromyelitis optica spectrum disorder 10.3
22 supranuclear ocular palsy 10.3
23 narcolepsy 1 10.2 HCRT MOG
24 obstructive hydrocephalus 10.2 AQP4 NF1
25 panencephalitis, subacute sclerosing 10.2 MBP MOG
26 autoimmune optic neuritis 10.2 AQP4 MBP MOG
27 strabismus 10.2
28 ocular motor apraxia 10.2
29 aceruloplasminemia 10.2
30 ptosis 10.2
31 vasculitis 10.2
32 mechanical strabismus 10.2
33 glioma 10.2
34 tuberculous meningitis 10.2
35 encephalitis 10.2 AQP4 LGI1 MOG
36 expressive language disorder 10.2 NF1 PSEN1
37 neuroretinitis 10.1 AQP4 IFNB1 MOG
38 transverse myelitis 10.1 AQP4 MBP
39 autoimmune disease of peripheral nervous system 10.1 HCRT MBP MOG
40 oculomotor nerve paralysis 10.1 KANTR MBP
41 third cranial nerve disease 10.1 KANTR MBP
42 tabes dorsalis 10.0 KANTR MBP
43 pernicious anemia 10.0
44 sarcoidosis 1 10.0
45 temporal arteritis 10.0
46 chiari malformation type ii 10.0
47 3-methylglutaconic aciduria, type iii 10.0
48 sjogren syndrome 10.0
49 tay-sachs disease 10.0
50 ataxia and polyneuropathy, adult-onset 10.0

Comorbidity relations with Internuclear Ophthalmoplegia via Phenotypic Disease Network (PDN):


Hypertension, Essential

Graphical network of the top 20 diseases related to Internuclear Ophthalmoplegia:



Diseases related to Internuclear Ophthalmoplegia

Symptoms & Phenotypes for Internuclear Ophthalmoplegia

UMLS symptoms related to Internuclear Ophthalmoplegia:


ophthalmoplegia, spasm of conjugate gaze, anomalies of divergence

MGI Mouse Phenotypes related to Internuclear Ophthalmoplegia:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.97 AQP4 CD55 HCRT LGI1 MBP MOG
2 hematopoietic system MP:0005397 9.96 AQP4 CD55 CXCR5 GKN2 IFNB1 MBP
3 immune system MP:0005387 9.85 AQP4 CXCR5 GKN2 IFNB1 MBP MOG
4 normal MP:0002873 9.56 CXCR5 IFNB1 MBP NF1 OMG PSEN1
5 vision/eye MP:0005391 9.17 AQP4 LGI1 MBP MOG NF1 PSEN1

Drugs & Therapeutics for Internuclear Ophthalmoplegia

Drugs for Internuclear Ophthalmoplegia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
4-Aminopyridine Approved Phase 2 504-24-5 1727
2 Potassium Channel Blockers Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study and Treatment of Visual Dysfunction and Motor Fatigue in Multiple Sclerosis Completed NCT02391961 Phase 2 Dalfampridine;Placebo

Search NIH Clinical Center for Internuclear Ophthalmoplegia

Genetic Tests for Internuclear Ophthalmoplegia

Anatomical Context for Internuclear Ophthalmoplegia

MalaCards organs/tissues related to Internuclear Ophthalmoplegia:

42
Eye, Brain, Testes, Pons, Spinal Cord

Publications for Internuclear Ophthalmoplegia

Articles related to Internuclear Ophthalmoplegia:

(show top 50) (show all 291)
# Title Authors Year
1
Diagnosing and quantifying a common deficit in multiple sclerosis: Internuclear ophthalmoplegia. ( 31004067 )
2019
2
Torsional internuclear ophthalmoplegia in acute ischemic stroke. ( 31041134 )
2019
3
Isolated bilateral internuclear ophthalmoplegia due to lacunar infarction. ( 29170848 )
2018
4
Teaching Video NeuroImages: Pulsatile proptosis and wall-eyed bilateral internuclear ophthalmoplegia. ( 29686128 )
2018
5
Uveitis and internuclear ophthalmoplegia as ocular manifestations of sarcoidosis. ( 29942190 )
2018
6
Editors' note: Impaired vestibular responses in internuclear ophthalmoplegia: Association and dissociation. ( 30150270 )
2018
7
Reader response: Impaired vestibular responses in internuclear ophthalmoplegia: Association and dissociation. ( 30150271 )
2018
8
Author response: Impaired vestibular responses in internuclear ophthalmoplegia: Association and dissociation. ( 30150272 )
2018
9
Wall-eyed Bilateral Internuclear Ophthalmoplegia (WEBINO) in a Patient With Idiopathic Intracranial Hypertension. ( 30169368 )
2018
10
Determining the Etiology of Internuclear Ophthalmoplegia in a Patient with a Cardiac Pacemaker and Complex Neurological Presentation. ( 30198234 )
2018
11
Bilateral pseudo-internuclear ophthalmoplegia in a patient with myasthenia gravis. ( 30294700 )
2018
12
Editors' note: Teaching Video NeuroImages: Pulsatile proptosis and wall-eyed bilateral internuclear ophthalmoplegia. ( 30397041 )
2018
13
Reader response: Teaching Video NeuroImages: Pulsatile proptosis and wall-eyed bilateral internuclear ophthalmoplegia. ( 30397042 )
2018
14
Author response: Teaching Video NeuroImages: Pulsatile proptosis and wall-eyed bilateral internuclear ophthalmoplegia. ( 30397043 )
2018
15
Teaching Video NeuroImages: Pulsatile proptosis and wall-eyed bilateral internuclear ophthalmoplegia. ( 30397047 )
2018
16
Nine Syndrome: Case Report and Review of Clinical Signs in Internuclear Ophthalmoplegia. ( 30532368 )
2018
17
Internuclear Ophthalmoplegia Secondary to Cocaine Abuse. ( 28265477 )
2017
18
Internuclear ophthalmoplegia. ( 27927777 )
2017
19
Isolated Internuclear Ophthalmoplegia After Massive Supratentorial Epidural Hematoma: A Case Report and Review of the Literature. ( 28143728 )
2017
20
A rare cause for visual symptoms in multiple sclerosis: posterior internuclear ophthalmoplegia of Lutz, a historical misnomer. ( 28194531 )
2017
21
Saccadic hypermetria on abduction of the ipsilesional eye in internuclear ophthalmoplegia. ( 28431591 )
2017
22
Bilateral internuclear ophthalmoplegia following head trauma. ( 28440256 )
2017
23
Post-operative unilateral internuclear ophthalmoplegia following basilar pneumocephalus after resection of C1 intradural extramedullary tumor. ( 28558345 )
2017
24
Can Wernekink commissure syndrome and wall-eyed bilateral internuclear ophthalmoplegia be ascribed to neuromyelitis optica spectrum disorder? ( 28681309 )
2017
25
Orbital metastasis mimicking internuclear ophthalmoplegia: A case report and review. ( 28774543 )
2017
26
Preferential Impairment of the Contralesional Posterior Semicircular Canal in Internuclear Ophthalmoplegia. ( 29018402 )
2017
27
Impaired vestibular responses in internuclear ophthalmoplegia: Association and dissociation. ( 29142084 )
2017
28
Visualisation of the medial longitudinal fasciculus using fibre tractography in multiple sclerosis patients with internuclear ophthalmoplegia. ( 26787313 )
2016
29
Paramedian pons infarction with wall-eye monocular internuclear ophthalmoplegia syndrome. ( 26944331 )
2016
30
Internuclear ophthalmoplegia plus ataxia indicates a dorsomedial tegmental lesion at the pontomesencephalic junction. ( 26995360 )
2016
31
Unilateral internuclear ophthalmoplegia, strabismus and transient torsional nystagmus in focal pontine infarction. ( 27448548 )
2016
32
Pathways Linked to Internuclear Ophthalmoplegia on Diffusion-Tensor Imaging in a Case with Midbrain Infarction. ( 27567293 )
2016
33
A Case of Traumatic Unilateral Internuclear Ophthalmoplegia: Clinical Significance of Susceptibility-Weighted Imaging. ( 27857923 )
2016
34
Bilateral Internuclear Ophthalmoplegia as a Presenting Manifestation of Primary Sjögren's Syndrome. ( 27928415 )
2016
35
Gaze palsy and exotropia in internuclear ophthalmoplegia. ( 25911021 )
2015
36
Diagnostic Efficacy of Conventional MRI Pulse Sequences in the Detection of Lesions Causing Internuclear Ophthalmoplegia in Multiple Sclerosis Patients. ( 24599322 )
2015
37
Bilateral ptosis with wall-eyed bilateral internuclear ophthalmoplegia and vertical gaze paralysis. ( 24870222 )
2015
38
Periprocedural stroke presenting as isolated unilateral internuclear ophthalmoplegia. ( 25114281 )
2015
39
Unilateral internuclear ophthalmoplegia as an isolated presentation of metastatic melanoma. ( 25232840 )
2015
40
Wall-eyed bilateral internuclear ophthalmoplegia: review of pathogenesis, diagnosis, prognosis and management. ( 25308307 )
2015
41
Large basilar tip aneurysm causing anterior internuclear ophthalmoplegia. ( 25670869 )
2015
42
Internuclear ophthalmoplegia associated with anti-TNFα medication. ( 25790247 )
2015
43
Wall-eyed bilateral internuclear ophthalmoplegia. ( 26053827 )
2015
44
Unilateral internuclear ophthalmoplegia with upbeat nystagmus from ischemic origin: evidence for the paramedian tract neurons as a vertical neural integrator? ( 26550407 )
2015
45
Complete bilateral horizontal internuclear ophthalmoplegia as a sign of multiple sclerosis relapse. ( 23040719 )
2014
46
Ocular vestibular evoked myogenic potentials to head tap and cervical vestibular evoked myogenic potentials to air-conducted sounds in isolated internuclear ophthalmoplegia. ( 24238926 )
2014
47
Brainstem infarction with wall-eyed bilateral internuclear ophthalmoplegia syndrome and vertical one-and-a-half syndrome. ( 24424330 )
2014
48
Vertical gaze-evoked nystagmus and internuclear ophthalmoplegia as sole manifestations in paramedian pontine infarction. ( 24770935 )
2014
49
Jerky seesaw nystagmus with internuclear ophthalmoplegia as the presenting finding in systemic lupus erythematosus. ( 25455550 )
2014
50
Pontine infarction responsible for wall-eyed bilateral internuclear ophthalmoplegia syndrome. ( 29443142 )
2014

Variations for Internuclear Ophthalmoplegia

Expression for Internuclear Ophthalmoplegia

Search GEO for disease gene expression data for Internuclear Ophthalmoplegia.

Pathways for Internuclear Ophthalmoplegia

Pathways related to Internuclear Ophthalmoplegia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.46 HCRT MBP NF1 PSEN1
2 11.21 AQP4 MBP OMG

GO Terms for Internuclear Ophthalmoplegia

Biological processes related to Internuclear Ophthalmoplegia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cytosolic calcium ion concentration GO:0007204 9.33 CD55 CXCR5 HCRT
2 T cell activation involved in immune response GO:0002286 8.96 IFNB1 PSEN1
3 negative regulation of axonogenesis GO:0050771 8.62 OMG PSEN1

Sources for Internuclear Ophthalmoplegia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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