MCID: INT143
MIFTS: 62

Interstitial Cystitis

Categories: Rare diseases, Nephrological diseases

Aliases & Classifications for Interstitial Cystitis

MalaCards integrated aliases for Interstitial Cystitis:

Name: Interstitial Cystitis 12 76 53 59 37 43 3 15 73
Painful Bladder Syndrome 53 59 73
Bladder Pain Syndrome 53 59 73
Interstitial Cystitis/painful Bladder Syndrome 53 59
Interstitial Cystitis/bladder Pain Syndrome 53 59
Trigonitis 53 73
Ic/bps 53 59
Ic/pbs 53 59
Ic 53 3
Chronic Interstitial Cystitis 73
Pelvic Congestion Syndrome 73
Cystitis, Interstitial 44
Pelvic Pain Syndrome 53
Ulcerative Cystitis 12
Pelvic Pain 43
Pbs 53

Characteristics:

Orphanet epidemiological data:

59
interstitial cystitis
Prevalence: 1-5/10000 (Finland),1-5/10000 (United States),1-9/1000000 (Finland); Age of onset: All ages; Age of death: normal life expectancy;

Classifications:



External Ids:

Disease Ontology 12 DOID:13949
MeSH 44 D018856
NCIt 50 C27189
SNOMED-CT 68 111409009 197834003
Orphanet 59 ORPHA37202
UMLS via Orphanet 74 C1720830 C0282488 C3160917 more
MESH via Orphanet 45 D018856
ICD10 via Orphanet 34 N30.1
KEGG 37 H01551
ICD10 33 N30.1

Summaries for Interstitial Cystitis

NIH Rare Diseases : 53 Interstitial cystitis (IC) is a chronic condition that causes painful urinary symptoms. Symptoms and severity can vary. Some people may have only mild discomfort, or feel tenderness or pressure in the bladder or pelvis. Others may experience intense bladder pain, urgent or frequent needs to urinate, or pain during sexual intercourse. Symptoms may be constant, or they may come and go. Some people with IC have Hunner's ulcers (areas of inflammation on the bladder wall, identified by cytoscopy). The exact cause of IC is not known. While the symptoms are similar to those of a bladder infection, IC is not an infection. It occurs more commonly in women, and in people with other chronic pain disorders such as irritable bowel syndrome or fibromyalgia. There is no cure for IC, but there are treatment options to help relieve the symptoms. No single treatment works for all people with IC. Often, people try different treatments or combinations of treatments before finding something that works. Treatment options may include lifestyle changes, oral or topical medications, bladder instillations, neuromodulation therapy, Botox injections in the bladder muscles, and surgery (in rare cases). Without treatment, IC can affect a person's sleep, daily activities, and social life.

MalaCards based summary : Interstitial Cystitis, also known as painful bladder syndrome, is related to migraine with or without aura 1 and paine syndrome, and has symptoms including unspecified symptom associated with female genital organs, mittelschmerz and pain and other symptoms associated with female genital organs. An important gene associated with Interstitial Cystitis is TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1), and among its related pathways/superpathways are ERK Signaling and Akt Signaling. The drugs Acetylcholine and Dexmedetomidine have been mentioned in the context of this disorder. Affiliated tissues include testes, kidney and prostate, and related phenotypes are pollakisuria and urinary bladder inflammation

MedlinePlus : 43 Interstitial cystitis (IC) is a condition that causes discomfort or pain in the bladder and a need to urinate frequently and urgently. It is far more common in women than in men. The symptoms vary from person to person. Some people may have pain without urgency or frequency. Others have urgency and frequency without pain. Women's symptoms often get worse during their periods. They may also have pain with sexual intercourse. The cause of IC isn't known. There is no one test to tell if you have it. Doctors often run tests to rule out other possible causes of symptoms. There is no cure for IC, but treatments can help most people feel better. They include Distending, or inflating, the bladder Bathing the inside of the bladder with a drug solution Oral medicines Electrical nerve stimulation Physical therapy Lifestyle changes Bladder training In rare cases, surgery NIH: National Institute of Diabetes and Digestive and Kidney Diseases

CDC : 3 Interstitial Cystitis (IC) is a chronic bladder condition resulting in recurring discomfort or pain in the bladder or surrounding pelvic region. People with IC usually have inflamed or irritated bladder walls which can cause scarring and stiffening of the bladder. 

Wikipedia : 76 Interstitial cystitis (IC), also known as bladder pain syndrome (BPS), is a type of chronic pain that... more...

Related Diseases for Interstitial Cystitis

Diseases in the Interstitial Cystitis family:

Chronic Interstitial Cystitis

Diseases related to Interstitial Cystitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 181)
# Related Disease Score Top Affiliating Genes
1 migraine with or without aura 1 30.4 P2RX3 TAC1 TRPV1
2 paine syndrome 30.3 NGF TAC1 TRPV1 UPK3A
3 chronic cystitis 29.8 NGF UPK3A
4 esophagitis 29.8 CXCL8 IL6 TRPV1
5 bladder disease 29.6 HBEGF IL6 NGF P2RX3 TAC1 TRPV1
6 pulmonary disease, chronic obstructive 29.2 CXCL8 CXCR3 IL6 TRPV1
7 somatoform disorder 28.7 IL4 NGF TAC1 TRPV1
8 colitis 28.4 CXCL8 IL4 IL6
9 cystitis 27.8 CXCL8 EGF HBEGF IL6 KNG1 NGF
10 asthma 25.5 BDNF CXCL8 IL4 IL6 KNG1 NGF
11 chronic interstitial cystitis 12.4
12 congenital disorder of glycosylation, type ic 12.3
13 pseudohypoparathyroidism, type ic 12.3
14 cutis laxa, autosomal recessive, type ic 12.1
15 glycogen storage disease ic 12.1
16 neuropathy, hereditary sensory and autonomic, type ic 12.1
17 usher syndrome, type ic 12.1
18 amelogenesis imperfecta, type ic 12.0
19 lymphedema, hereditary, ic 12.0
20 prune belly syndrome 11.9
21 isolated focal cortical dysplasia type ic 11.9
22 iridocorneal endothelial syndrome 11.9
23 alg6-congenital disorder of glycosylation 11.7
24 urethral syndrome 11.4
25 chronic pain 11.4
26 plastic bronchitis 11.2
27 charcot-marie-tooth disease, demyelinating, type 1c 11.2
28 myasthenic syndrome, congenital, 5 11.2
29 ichthyosis--cheek--eyebrow syndrome 11.1
30 corneal endothelial dystrophy 11.0
31 cogan-reese syndrome 11.0
32 convulsions, familial infantile, with paroxysmal choreoathetosis 11.0
33 essential iris atrophy 11.0
34 ciliary dyskinesia, primary, 1 11.0
35 muscular dystrophy, limb-girdle, type 1c 11.0
36 autosomal dominant limb-girdle muscular dystrophy type 1c 11.0
37 navicular bone, accessory 10.8
38 congenital disorder of glycosylation, type ib 10.8
39 tendinitis 10.8
40 joint disorders 10.8
41 pica disease 10.8
42 diarrhea 10.8
43 cholera 10.8
44 bursitis 10.8
45 persistent genital arousal disorder 10.8
46 piriformis syndrome 10.8
47 chylomicronemia, familial, due to circulating inhibitor of lipoprotein lipase 10.8
48 primary ciliary dyskinesia 10.8
49 recurrent corneal erosion 10.7 CXCL8 IL6
50 bagassosis 10.6 CXCL8 IL6

Comorbidity relations with Interstitial Cystitis via Phenotypic Disease Network (PDN):


Acute Cystitis Prostatic Hypertrophy

Graphical network of the top 20 diseases related to Interstitial Cystitis:



Diseases related to Interstitial Cystitis

Symptoms & Phenotypes for Interstitial Cystitis

Human phenotypes related to Interstitial Cystitis:

59 32 (show all 13)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 pollakisuria 59 32 hallmark (90%) Very frequent (99-80%) HP:0100515
2 urinary bladder inflammation 59 32 hallmark (90%) Very frequent (99-80%) HP:0100577
3 abnormality of the vagina 59 32 occasional (7.5%) Occasional (29-5%) HP:0000142
4 urinary urgency 59 32 hallmark (90%) Very frequent (99-80%) HP:0000012
5 nocturia 59 32 hallmark (90%) Very frequent (99-80%) HP:0000017
6 abnormality of the labia 59 32 hallmark (90%) Very frequent (99-80%) HP:0000058
7 abnormality of the menstrual cycle 59 32 hallmark (90%) Very frequent (99-80%) HP:0000140
8 abnormality of the urethra 59 32 hallmark (90%) Very frequent (99-80%) HP:0000795
9 pain 59 32 hallmark (90%) Very frequent (99-80%) HP:0012531
10 dyspareunia 59 32 hallmark (90%) Very frequent (99-80%) HP:0030016
11 functional abnormality of the bladder 59 Very frequent (99-80%)
12 abnormality of the bladder 59 Very frequent (99-80%)
13 abnormality of the genital system 59 Very frequent (99-80%)

UMLS symptoms related to Interstitial Cystitis:


unspecified symptom associated with female genital organs, mittelschmerz, pain and other symptoms associated with female genital organs, other specified symptoms associated with female genital organs, female genital pain and other symptoms

MGI Mouse Phenotypes related to Interstitial Cystitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.02 UMOD IL4 IL6 KNG1 BDNF NGF
2 homeostasis/metabolism MP:0005376 10 IL4 UPK3A IL6 BDNF NGF CDH1
3 cardiovascular system MP:0005385 9.97 IL6 NGF CDH1 P2RX3 CXCR3 TAC1
4 integument MP:0010771 9.85 IL6 BDNF NGF CDH1 P2RX3 TAC1
5 normal MP:0002873 9.56 IL4 BDNF NGF CDH1 CXCR3 TAC1
6 renal/urinary system MP:0005367 9.17 UPK3A IL6 CXCR3 TAC1 TRPV1 UMOD

Drugs & Therapeutics for Interstitial Cystitis

Drugs for Interstitial Cystitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 163)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved Phase 4,Phase 2,Phase 1 51-84-3 187
2
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
3
Oxytocin Approved, Vet_approved Phase 4 50-56-6 439302 53477758
4
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
5
Morphine Approved, Investigational Phase 4 57-27-2 5288826
6
Acetaminophen Approved Phase 4 103-90-2 1983
7
Cycloserine Approved Phase 4 68-41-7 401 6234
8
Metoprolol Approved, Investigational Phase 4 37350-58-6, 51384-51-1 4171
9
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
10
gamma-Aminobutyric acid Approved, Investigational Phase 4 56-12-2 119
11
Belladonna Approved, Experimental, Nutraceutical Phase 4
12
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
13 abobotulinumtoxinA Phase 4,Phase 2,Phase 1
14 Botulinum Toxins Phase 4,Phase 2,Phase 1
15 Botulinum Toxins, Type A Phase 4,Phase 2,Phase 1
16 Cholinergic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
17 Neuromuscular Agents Phase 4,Phase 2,Phase 1
18 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
19 onabotulinumtoxinA Phase 4,Phase 2,Phase 1
20 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
21 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Not Applicable
22 Anti-Arrhythmia Agents Phase 4,Phase 2,Not Applicable
23 Adrenergic Agents Phase 4,Phase 3
24 Adrenergic Agonists Phase 4,Phase 3
25 Adrenergic alpha-2 Receptor Agonists Phase 4
26 Adrenergic alpha-Agonists Phase 4
27 Analgesics Phase 4,Phase 3,Phase 2
28 Analgesics, Non-Narcotic Phase 4,Phase 3
29 Anti-Anxiety Agents Phase 4
30 Hypnotics and Sedatives Phase 4,Not Applicable
31 Oxytocics Phase 4
32 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2
33 Anti-Inflammatory Agents, Non-Steroidal Phase 4
34 Antirheumatic Agents Phase 4,Phase 3,Phase 2
35 Cyclooxygenase Inhibitors Phase 4
36 Ketorolac Tromethamine Phase 4
37 Analgesics, Opioid Phase 4,Phase 2
38 Narcotics Phase 4,Phase 2
39 Opiate Alkaloids Phase 4
40 Anti-Bacterial Agents Phase 4,Phase 3
41 Antibiotics, Antitubercular Phase 4,Phase 3
42 Anti-Infective Agents Phase 4,Phase 3,Phase 2
43 Antimetabolites Phase 4
44 Antitubercular Agents Phase 4,Phase 3
45 Renal Agents Phase 4
46 Autonomic Agents Phase 4,Phase 3,Not Applicable
47 Anticoagulants Phase 4,Phase 2
48 Antiparkinson Agents Phase 4,Phase 3
49 Calcium, Dietary Phase 4,Phase 2
50 Psychotropic Drugs Phase 4,Phase 3

Interventional clinical trials:

(show top 50) (show all 149)
# Name Status NCT ID Phase Drugs
1 Clinical Efficacy of Changing the InterStim® Parameters in Patients With Interstitial Cystitis/Painful Bladder Syndrome Unknown status NCT01312259 Phase 4
2 Botulinum A Toxin in the Treatment of Patients With Painful Bladder Syndrome Unknown status NCT01157507 Phase 4 Intravesical injection of Botulinum A Toxin;Placebo
3 Usefulness of Dexmedetomidine on Post-operative Pain Management in Patients With Interstitial Cystitis Completed NCT01195116 Phase 4 Dexmedetomidine;Normal Saline
4 Intravesicular Onabotulinumtoxin A in Interstitial Cystitis Completed NCT02297100 Phase 4 Onabotulinumtoxin A
5 Intranasal Oxytocin for the Treatment of Pain Associated With Interstitial Cystitis Completed NCT00919802 Phase 4 Oxytocin
6 Intranasal Ketorolac Tromethamine (Sprix) for Acute Pain of Interstitial Cystitis Flare of Pain Completed NCT02000401 Phase 4 Ketorolac Tromethamine
7 Botox as a Treatment for Interstitial Cystitis in Women Completed NCT00194610 Phase 4 Botox
8 Reduction of Bladder Injection Pain With Belladonna Opiate Suppository Completed NCT02600715 Phase 4 Onabotulinumtoxin A (BoNT);belladonna;Morphine;Placebo;Active B&O suppository of belladonna
9 Treating Urological Chronic Pelvic Pain Syndrome (UCPPS) Pain Completed NCT02385266 Phase 4 D-Cycloserine;Placebo (for D-cycloserine)
10 Interstitial Cystitis: Examination of the Central Autonomic Network Recruiting NCT03008382 Phase 4 Metoprolol Tartrate Oral Tablet;Placebo Oral Tablet
11 Chronic Pain Risk Associated With Menstrual Period Pain Recruiting NCT02214550 Phase 4 microgestin 1/20
12 Effectiveness and Safety Study of Pentosan Polysulfate Sodium for the Treatment of Interstitial Cystitis Terminated NCT00086684 Phase 4 Pentosan polysulfate sodium 100 mg;Placebo;Pentosan polysulfate sodium 100 mg
13 Efficacy of Gralise® for Chronic Pelvic Pain Terminated NCT01678911 Phase 4 Gralise
14 Trial of Viagra' in Men With Chronic Pelvic Pain Syndrome Type III Terminated NCT00194597 Phase 4 Viagra (sildenafil citrate)
15 Acupuncture for the Treatment of Interstitial Cystitis (IC) Symptoms Unknown status NCT00094874 Phase 3
16 Efficacy Study of Adalimumab to Treat Interstitial Cystitis Completed NCT01295814 Phase 3 Adalimumab
17 Omalizumab in Interstitial Cystitis/Bladder Pain Syndrome Completed NCT01294878 Phase 3 omalizumab
18 URACYST® For the Treatment of GAG Deficient Interstitial Cystitis Completed NCT00150488 Phase 2, Phase 3
19 Efficacy of Amitriptyline for Painful Bladder Syndrome (PBS) Completed NCT00124306 Phase 3 Amitriptyline
20 Pilot Study Evaluating the Efficacy of Certolizumab Pegol for Interstitial Cystitis Completed NCT02497976 Phase 3 Placebo
21 A Long-term, Safety and Efficacy Study of Intranasal Esketamine in Treatment-resistant Depression Completed NCT02497287 Phase 3 Esketamine (Intranasal Spray);Duloxetine (Oral Antidepressant);Escitalopram (Oral Antidepressant);Sertraline (Oral Antidepressant);Venlafaxine Extended Release (XR) (Oral Antidepressant)
22 A Pilot Study of the Effects of Mirabegron on Symptoms in Patients With Interstitial Cystitis Recruiting NCT02787083 Phase 3 Mirabegron;Placebo
23 Efficacy and Safety of 2 Doses of AQX-1125 in Subjects With Interstitial Cystitis / Bladder Pain Syndrome Active, not recruiting NCT02858453 Phase 3 AQX-1125 100 mg;AQX-1125 200 mg;Placebo
24 Efficacy Study of Bladder Instillation and Gabapentin on Interstitial Cystitis/Bladder Pain Syndrome. Not yet recruiting NCT03463915 Phase 3 Gabapentin Oral Capsule [Neurontin];Placebo Oral Capsule [CEBOCAP]
25 A Randomized Multicenter Double-Blind CT to Evaluate the Efficacy and Safety of Mycophenolate Mofetil . . . Terminated NCT00451867 Phase 3 Mycophenolate Mofetil;Mycofenolate Mofetil (MMF);Placebo
26 Efficacy of Botulinum Toxin Type A in Patients With Bladder Pain Syndrome/Intersticial Cystitis and Hunners' Lesions Unknown status NCT01437579 Phase 2
27 Cyclosporine in Interstitial Cystitis: Efficacy, Safety and Mechanism of Action Completed NCT01990898 Phase 2 Cyclosporine
28 Prospective Trial Comparing Response to Hyperbaric Oxygen Treatment in Patients With Interstitial Cystitis Completed NCT01479725 Phase 2
29 Efficacy and Safety Study of Uracyst to Treat Interstitial Cystitis/Painful Bladder Syndrome Completed NCT00919113 Phase 2 2% sodium chondroitin sulfate;Placebo
30 Interstitial Cystitis Completed NCT00056251 Phase 2
31 An Effectiveness And Safety Study Of PD 0299685 For The Treatment Of Symptoms Associated With Interstitial Cystitis Completed NCT00739739 Phase 2 PD 0299685 at 15mg BID;PD 0299685 at 30mg BID;placebo for PD 0299685
32 Intravesical Botulinum Toxin A Injections in Treatment of Interstitial Cystitis Refractory to Conventional Treatment Completed NCT01969773 Phase 2 Botulinum toxin A;Normal saline instillation
33 Phase II Study Efficacy and Safety of Two Dosing Regimens of MN-001 in Patients With Interstitial Cystitis Completed NCT00295854 Phase 2 MN-001 BID;MN-001;Placebo
34 A Pilot Clinical Investigation of the Efficacy and Safety of Uracyst® Versus Placebo in Patients With Interstitial Cystitis/Painful Bladder Syndrome. Completed NCT00527917 Phase 2
35 A Safety and Efficacy Study of LiRIS® in Females With Interstitial Cystitis/Bladder Pain Syndrome Completed NCT02411110 Phase 2
36 Intravesical Instillation of Liposome Encapsulated Botulinum Toxin A (Lipotoxin) in Treatment of Interstitial Cystitis Completed NCT02247557 Phase 2 Liposome encapsulated BoNT-A;BOTOX 200U in normal saline;Normal saline
37 An Effectiveness and Safety Study of PF-04383119 for the Treatment of Pain in Interstitial Cystitis Completed NCT00601484 Phase 2 PF-04383119;Placebo
38 Study of Biomarkers and the Relaxation Response Using Guided Imagery in Women With IC Completed NCT00420550 Phase 2
39 A Randomized Study Comparing Placebo and ASP3652 in the Treatment of Women With Bladder Pain Syndrome / Interstitial Cystitis (BPS/IC) Completed NCT01613586 Phase 2 ASP3652;Placebo
40 Efficacy and Safety of AQX-1125 in IC/BPS Completed NCT01882543 Phase 2 AQX-1125;Placebo
41 A Safety and Efficacy Study of LiRIS® in Females With Interstitial Cystitis With Hunner's Lesions Completed NCT02395042 Phase 2 LiRIS®;LiRIS Placebo
42 Phase I/II Randomized, Placebo-Controlled Study of Capsaicin for Interstitial Cystitis and Vulvar Vestibulitis Completed NCT00004316 Phase 1, Phase 2 capsaicin
43 Efficacy and Safety of Intravesical Instillations of Botulinum Toxin in TC-3 Gel in IC Patients Completed NCT01997983 Phase 1, Phase 2
44 The Safety and Efficacy of Gefapixant (AF-219/MK-7264) in Female Subjects With Interstitial Cystitis /Bladder Pain Syndrome Completed NCT01569438 Phase 2 Gefapixant;Sugar Pill
45 Study of URG101 in Painful Bladder Syndrome and Interstitial Cystitis Completed NCT00517868 Phase 2 URG101;Placebo
46 OXN PR vs Placebo in Opioid-naive Subjects Suffering From Severe Pain Due to Bladder Pain Syndrome (BPS) Completed NCT01197261 Phase 2 Oxycodone naloxone prolonged release tablets;Placebo tablets
47 Study of U101 for Bladder Pain and/or Urgency Completed NCT00256542 Phase 2 Alkalinized Lidocaine-Heparin
48 A Study to Evaluate the Safety and Efficacy of Intranasal Esketamine in Treatment-resistant Depression Completed NCT01998958 Phase 2 Esketamine 14 mg;Esketamine 28 mg;Esketamine 56 mg;Esketamine 84 mg;Placebo
49 A Study to Investigate Efficacy, Safety, Pharmacodynamics and Pharmacokinetics of ASP6294 in the Treatment of Female Subjects With Bladder Pain Syndrome/Interstitial Cystitis Recruiting NCT03282318 Phase 2 ASP6294;Placebo
50 Evaluation of Intravesical LP08 in Patients With Interstitial Cystitis/Painful Bladder Syndrome Recruiting NCT01393223 Phase 2 LP-08 80mg;Normal Saline Placebo;LP-08 20mg

Search NIH Clinical Center for Interstitial Cystitis

Cochrane evidence based reviews: cystitis, interstitial

Genetic Tests for Interstitial Cystitis

Anatomical Context for Interstitial Cystitis

MalaCards organs/tissues related to Interstitial Cystitis:

41
Testes, Kidney, Prostate, Brain, Skin, Endothelial, Pituitary

Publications for Interstitial Cystitis

Articles related to Interstitial Cystitis:

(show top 50) (show all 464)
# Title Authors Year
1
Validation of the Spanish version of the Bladder Pain/Interstitial Cystitis-Symptom Score (BPIC-SS) questionnaire. A useful tool for the diagnosis of bladder pain syndrome. ( 29650471 )
2018
2
Safety and Feasibility of Intravesical Instillation of Botulinum Toxin-A in Hydrogel-based Slow-release Delivery System in Patients With Interstitial Cystitis-Bladder Pain Syndrome: A Pilot Study. ( 29307733 )
2018
3
Urinary and psychological outcomes in women with interstitial cystitis/bladder pain syndrome following hyaluronic acid treatment. ( 29880165 )
2018
4
Crosstalk between the immune system and neural pathways in interstitial cystitis/bladder pain syndrome. ( 29906407 )
2018
5
The efficacy of botulinum toxin A and sacral neuromodulation in the management of interstitial cystitis (IC)/bladder pain syndrome (BPS), what do we know? ICI-RS 2017 think thank, Bristol. ( 29363792 )
2018
6
Comparison of inflammatory urine markers in patients with interstitial cystitis and overactive bladder. ( 29372285 )
2018
7
Animal Model of Interstitial Cystitis/Bladder Pain Syndrome. ( 29385782 )
2018
8
Differences in Urodynamic Parameters According to the Presence of a Hunner Lesion in Women With Interstitial Cystitis/Bladder Pain Syndrome. ( 29385787 )
2018
9
Animal Modelling of Interstitial Cystitis/Bladder Pain Syndrome. ( 29385788 )
2018
10
Downregulation of WNT11 is associated with bladder tissue fibrosis in patients with interstitial cystitis/bladder pain syndrome without Hunner lesion. ( 29955137 )
2018
11
Comparative study of efficacy and safety between bladder body and trigonal intravesical onabotulinumtoxina injection in the treatment of interstitial cystitis refractory to conventional treatment-A prospective, randomized, clinical trial. ( 29331031 )
2018
12
Advances in intravesical therapy for bladder pain syndrome (BPS)/interstitial cystitis (IC). ( 29341502 )
2018
13
Improving the utility of clinical phenotyping in interstitial cystitis/painful bladder syndrome: from UPOINT to INPUT. ( 29680002 )
2018
14
Endometriosis increased the risk of bladder pain syndrome/interstitial cystitis: A population-based study. ( 29318645 )
2018
15
Epstein-Barr Virus Presence as a Potential Etiology of Persistent Bladder Inflammation in Human Interstitial Cystitis/Bladder Pain Syndrome. ( 29653163 )
2018
16
FDA Brudac 2018 Criteria for Interstitial Cystitis/Bladder Pain Syndrome Clinical Trials: Future Direction for IC/BPS Research. ( 29452126 )
2018
17
An evaluation of the pharmacotherapy for interstitial cystitis. ( 29972328 )
2018
18
Management of interstitial cystitis/bladder pain syndrome. ( 29875041 )
2018
19
Repetitive transcranial magnetic stimulation for chronic neuropathic pain in patients with bladder pain syndrome/interstitial cystitis. ( 29797500 )
2018
20
Female Veterans With Diagnoses of Both Chronic Pelvic Pain and Overactive Bladder; How Do They Compare to Women Diagnosed With Interstitial Cystitis? ( 29746393 )
2018
21
Bladder pain syndrome/interstitial cystitis is associated with asthma: A case-control study. ( 29441652 )
2018
22
Distribution of mast cell subtypes in interstitial cystitis: implications for novel diagnostic and therapeutic strategies? ( 29764932 )
2018
23
IL-33 mast cell axis is central in LL-37 induced bladder inflammation and pain in a murine interstitial cystitis model. ( 29784508 )
2018
24
Inflammation and Tissue Remodeling in the Bladder and Urethra in Feline Interstitial Cystitis. ( 29706873 )
2018
25
Oncosuppressor protein p53 and cyclin-dependent kinase inhibitor p21 regulate interstitial cystitis associated gene expression. ( 29729649 )
2018
26
Prodrome and Non-prodrome Phenotypes of Bladder Pain Syndrome/Interstitial Cystitis. ( 29775697 )
2018
27
Electron microscopic characteristics of interstitial cystitis/bladder pain syndrome and their association with clinical condition. ( 29879217 )
2018
28
Extent of Hunner lesions: The relationships with symptom severity and clinical parameters in Hunner type interstitial cystitis patients. ( 29315774 )
2018
29
Will cesarean section increase the risk of interstitial cystitis/painful bladder syndrome? ( 29717503 )
2018
30
Novel contrast mixture achieves contrast resolution of human bladder wall suitable for T1 mapping: applications in interstitial cystitis and beyond. ( 29392488 )
2018
31
Endoscopic Injection of Low Dose Triamcinolone: A Simple, Minimally Invasive, and Effective Therapy for Interstitial Cystitis With Hunner Lesions. ( 29782887 )
2018
32
A genome-scale DNA methylation study in women with interstitial cystitis/bladder pain syndrome. ( 29363787 )
2018
33
A central role for toll-like 4 (TLR4) receptors in interstitial cystitis? ( 29949393 )
2018
34
Re: Long-Term Outcomes of Intravesical Dimethyl Sulfoxide/Heparin/Hydrocortisone Therapy for Interstitial Cystitis/Bladder Pain Syndrome. ( 29642365 )
2018
35
An Immunogenic Peptide, T2 Induces Interstitial Cystitis/Painful Bladder Syndrome: an Autoimmune Mouse Model for Interstitial Cystitis/Painful Bladder Syndrome. ( 28799018 )
2017
36
Somatic symptoms are sensitive in predicting interstitial cystitis/bladder pain syndrome. ( 28486876 )
2017
37
The role of TSG-6 and uroplakin III in bladder pain syndrome/ interstitial cystitis in rats and humans. ( 29299202 )
2017
38
Repeated intravesical injections of platelet-rich plasma are effective in the treatment of interstitial cystitis: a case control pilot study. ( 29265766 )
2017
39
Naftopidil Improves Symptoms in a Rat Model of Tranilast-Induced Interstitial Cystitis. ( 28394500 )
2017
40
Therapeutic effect of urine-derived stem cells for protamine/lipopolysaccharide-induced interstitial cystitis in a rat model. ( 28482861 )
2017
41
Inhibition of microRNA-214 promotes epithelial-mesenchymal transition process and induces interstitial cystitis in postmenopausal women by upregulating Mfn2. ( 28729638 )
2017
42
A new player in interstitial cystitis/bladder pain syndrome: platelet-activating factor - PAF and its connection to smoking. ( 28408637 )
2017
43
Clinical comparison of intravesical hyaluronic acid and chondroitin sulfate therapies in the treatment of bladder pain syndrome/interstitial cystitis. ( 28480984 )
2017
44
Expression of programmed death ligand-1 on bladder tissues is detected in a clinically and histologically well-defined interstitial cystitis cohort. ( 29277923 )
2017
45
Transurethral Resection Alone Vs Resection Combined With Therapeutic Hydrodistention as Treatment for Ulcerative Interstitial Cystitis: Initial Experience With Propensity Score Matching Studies. ( 27720770 )
2017
46
Efficacy, Side Effects, and Monitoring of Oral Cyclosporine in Interstitial Cystitis-Bladder Pain Syndrome. ( 28528859 )
2017
47
Sensory mapping of pelvic dermatomes in women with interstitial cystitis/bladder pain syndrome. ( 28628232 )
2017
48
Childhood bladder and bowel dysfunction predicts irritable bowel syndrome phenotype in adult interstitial cystitis/bladder pain syndrome patients. ( 28798827 )
2017
49
Psychosocial co-morbidities in Interstitial Cystitis/Bladder Pain syndrome (IC/BPS): A systematic review. ( 28990698 )
2017
50
Fulranumab in patients with interstitial cystitis/bladder pain syndrome: observations from a randomized, double-blind, placebo-controlled study. ( 28056917 )
2017

Variations for Interstitial Cystitis

Expression for Interstitial Cystitis

Search GEO for disease gene expression data for Interstitial Cystitis.

Pathways for Interstitial Cystitis

Pathways related to Interstitial Cystitis according to GeneCards Suite gene sharing:

(show all 22)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.65 BDNF CDH1 CXCL8 CXCR3 EGF HBEGF
2
Show member pathways
13.17 BDNF CXCL8 CXCR3 EGF IL4 IL6
3
Show member pathways
13.03 BDNF EGF HBEGF IL6 NGF P2RX3
4
Show member pathways
12.89 BDNF EGF HBEGF IL6 NGF
5
Show member pathways
12.87 BDNF CDH1 CXCL8 CXCR3 EGF HBEGF
6
Show member pathways
12.8 BDNF EGF IL4 IL6 NGF
7
Show member pathways
12.79 BDNF EGF HBEGF IL4 IL6 NGF
8 12.63 CDH1 CXCL8 EGF IL4 IL6
9
Show member pathways
12.45 CXCL8 EGF IL4 IL6
10
Show member pathways
11.95 EGF HBEGF IL6
11 11.87 BDNF CXCL8 IL6 NGF TAC1
12 11.82 CXCL8 IL4 IL6
13 11.75 BDNF CXCL8 IL4 IL6
14 11.64 CXCL8 IL4 IL6
15 11.61 BDNF EGF NGF
16
Show member pathways
11.51 BDNF CDH1 CXCL8 EGF IL4 IL6
17 11.48 CXCL8 HBEGF IL6
18 11.42 CXCL8 EGF IL4 IL6
19 11.32 CXCL8 IL4 IL6
20 10.88 CDH1 CXCL8 EGF HBEGF UPK3A
21 10.87 CXCL8 IL6
22 10.71 BDNF EGF

GO Terms for Interstitial Cystitis

Cellular components related to Interstitial Cystitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.61 BDNF CXCL8 EGF HBEGF IL4 IL6
2 axon GO:0030424 9.46 BDNF NGF P2RX3 TAC1
3 extracellular region GO:0005576 9.36 BDNF CDH1 CXCL8 EGF HBEGF IL4

Biological processes related to Interstitial Cystitis according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of apoptotic process GO:0043065 9.84 IL6 KNG1 NGF TRPV1
2 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.58 EGF HBEGF IL6
3 response to pain GO:0048265 9.55 TAC1 TRPV1
4 nerve development GO:0021675 9.52 BDNF NGF
5 locomotion GO:0040011 9.51 BDNF NGF
6 negative regulation of ERBB signaling pathway GO:1901185 9.49 EGF HBEGF
7 positive regulation of acute inflammatory response GO:0002675 9.48 IL6 TAC1
8 nerve growth factor signaling pathway GO:0038180 9.46 BDNF NGF
9 positive regulation of cytosolic calcium ion concentration GO:0007204 9.46 CXCR3 KNG1 TAC1 TRPV1
10 behavioral response to pain GO:0048266 9.43 P2RX3 TRPV1
11 regulation of signaling receptor activity GO:0010469 9.43 BDNF CXCL8 HBEGF IL4 IL6 NGF
12 regulation of protein localization to cell surface GO:2000008 9.37 BDNF EGF
13 positive regulation of collateral sprouting GO:0048672 9.32 BDNF NGF
14 urinary bladder smooth muscle contraction GO:0014832 9.26 P2RX3 TRPV1
15 inflammatory response GO:0006954 9.1 CXCL8 CXCR3 IL6 KNG1 TAC1 TRPV1

Molecular functions related to Interstitial Cystitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.1 BDNF EGF HBEGF IL4 IL6 NGF

Sources for Interstitial Cystitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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