MCID: INT011
MIFTS: 36

Interstitial Emphysema

Categories: Respiratory diseases

Aliases & Classifications for Interstitial Emphysema

MalaCards integrated aliases for Interstitial Emphysema:

Name: Interstitial Emphysema 12 15 71 32

Classifications:



External Ids:

Disease Ontology 12 DOID:10030
ICD9CM 34 518.1
NCIt 49 C34571
SNOMED-CT 67 11211003
ICD10 32 J98.2
UMLS 71 C1370824

Summaries for Interstitial Emphysema

MalaCards based summary : Interstitial Emphysema is related to respiratory distress syndrome in premature infants and pulmonary emphysema. An important gene associated with Interstitial Emphysema is SFTPB (Surfactant Protein B), and among its related pathways/superpathways are Diseases of metabolism and Lung fibrosis. The drugs Ibuprofen and Analgesics have been mentioned in the context of this disorder. Affiliated tissues include lung, heart and neutrophil, and related phenotype is respiratory system.

Related Diseases for Interstitial Emphysema

Diseases related to Interstitial Emphysema via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 71)
# Related Disease Score Top Affiliating Genes
1 respiratory distress syndrome in premature infants 29.7 SFTPC SFTPB SFTPA1 ABCA3
2 pulmonary emphysema 29.7 SFTPD SFTPC
3 meconium aspiration syndrome 29.6 TTN SLC22A4 SFTPB
4 diaphragmatic hernia, congenital 29.5 SLC22A4 SFTPC SFTPB
5 pneumonia 29.3 SFTPD SFTPC SFTPB
6 adult respiratory distress syndrome 29.2 SFTPD SFTPC SFTPB
7 bacterial pneumonia 29.1 SFTPD SFTPB
8 pulmonary disease, chronic obstructive 28.7 TTN SFTPD SFTPB
9 interstitial lung disease 28.6 SFTPD SFTPC SFTPB ABCA3
10 lung disease 28.6 SFTPD SFTPC SFTPB SFTPA1 ABCA3
11 respiratory failure 28.6 TTN SFTPD SFTPC SFTPB ABCA3
12 pulmonary fibrosis 28.5 SFTPD SFTPC SFTPA1 ABCA3
13 pulmonary fibrosis, idiopathic 27.9 SFTPD SFTPC SFTPB SFTPA1 ABCA3
14 newborn respiratory distress syndrome 27.9 TTN SLC22A4 SFTPD SFTPC SFTPB SFTPA1
15 pneumothorax 10.6
16 bronchopulmonary dysplasia 10.2
17 ventilation pneumonitis 10.2 SFTPB ABCA3
18 surfactant metabolism dysfunction, pulmonary, 1 10.2 SFTPB ABCA3
19 lymphangiectasis 10.2
20 lipid pneumonia 10.2 SFTPB ABCA3
21 pulmonary hemosiderosis 10.2 SFTPB ABCA3
22 pneumothorax, primary spontaneous 10.1
23 patent ductus arteriosus 1 10.1
24 chronic congestive splenomegaly 10.0 SFTPC ABCA3
25 pre-eclampsia 10.0
26 bronchiolitis 10.0
27 congestive heart failure 10.0
28 status asthmaticus 10.0
29 diaphragm disease 10.0 SFTPC SFTPB
30 constrictive pericarditis 9.9 WBP2NL TTN
31 tracheal agenesis 9.9 SFTPD SFTPB
32 laryngomalacia 9.8
33 cystic disease of lung 9.8
34 sudden infant death syndrome 9.8
35 asthma 9.8
36 langerhans cell histiocytosis 9.8
37 human immunodeficiency virus type 1 9.8
38 muscle hypertrophy 9.8
39 bacterial sepsis 9.8
40 cardiac arrest 9.8
41 asphyxia neonatorum 9.8
42 pertussis 9.8
43 heart disease 9.8
44 hellp syndrome 9.8
45 pneumatosis cystoides intestinalis 9.8
46 cystitis 9.8
47 histiocytosis 9.8
48 choriocarcinoma 9.8
49 pleural empyema 9.8
50 gastritis 9.8

Comorbidity relations with Interstitial Emphysema via Phenotypic Disease Network (PDN):


Deficiency Anemia Familial Atrial Fibrillation
Heart Disease Postinflammatory Pulmonary Fibrosis
Respiratory Failure Spontaneous Tension Pneumothorax

Graphical network of the top 20 diseases related to Interstitial Emphysema:



Diseases related to Interstitial Emphysema

Symptoms & Phenotypes for Interstitial Emphysema

MGI Mouse Phenotypes related to Interstitial Emphysema:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 respiratory system MP:0005388 9.02 ABCA3 SFTPA1 SFTPB SFTPC SFTPD

Drugs & Therapeutics for Interstitial Emphysema

Drugs for Interstitial Emphysema (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ibuprofen Approved 15687-27-1 3672
2 Analgesics
3 Analgesics, Non-Narcotic
4 Cyclooxygenase Inhibitors
5 Antirheumatic Agents
6 Anti-Inflammatory Agents
7 Anti-Inflammatory Agents, Non-Steroidal

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 High Frequency Ventilation in Premature Infants (HIFI) Completed NCT00000567 Phase 3
2 Definition of the Status of the Human Lung Stem Cell Niches ex Vivo in Tissue Biopsies Performed in Patients With Emphysema and Interstitial Fibrosis Compared to Non-diseased Areas Unknown status NCT02705144
3 An Observational Study of Non Contrast Computed Tomography in Assessment of Regional Ventilation of the Lung. Completed NCT02879773
4 SequelaeCov: a Prospective Study on Lung Damage Caused by SARS-CoV-2 Pneumonia Recruiting NCT04435327
5 Palliative Care to Improve Quality of Life in CHF and COPD Recruiting NCT02713347
6 Timing of PDA Closure and Respiratory Outcome in Premature Infants Terminated NCT00802685 Early ibuprofen

Search NIH Clinical Center for Interstitial Emphysema

Genetic Tests for Interstitial Emphysema

Anatomical Context for Interstitial Emphysema

MalaCards organs/tissues related to Interstitial Emphysema:

40
Lung, Heart, Neutrophil, Bone Marrow, Bone, Brain, Fetal Lung

Publications for Interstitial Emphysema

Articles related to Interstitial Emphysema:

(show top 50) (show all 539)
# Title Authors PMID Year
1
Reply to Risk factors for pulmonary interstitial emphysema in the preterm infant: still more challenges than answers. 61
32496636 2020
2
Preeclampsia was a risk factor for pulmonary interstitial emphysema in preterm infants born ≤32 weeks of gestational age. 61
32369221 2020
3
Clinical and imaging characteristics of hematologic disease complicated by air leak syndrome: A STROBE-compliment observational study. 61
32443296 2020
4
A de novo 2.2 Mb recurrent 17q23.1q23.2 deletion unmasks novel putative regulatory non-coding SNVs associated with lethal lung hypoplasia and pulmonary hypertension: a case report. 61
32143628 2020
5
Selective lung ventilation in the management of unilateral pulmonary interstitial emphysema. 61
31997483 2020
6
CT features of pulmonary interstitial emphysema. 61
31053558 2019
7
Pulmonary interstitial emphysema is a risk factor for poor prognosis and a cause of air leaks. 61
31043328 2019
8
Neonate with persisting respiratory distress after resolution of pneumothorax. 61
31506322 2019
9
Positional treatment without mechanical ventilation in a very preterm infant with unilateral pulmonary interstitial emphysema: case report and review of the literature. 61
31370828 2019
10
Delivery room interventions to prevent bronchopulmonary dysplasia in preterm infants: a protocol for a systematic review and network meta-analysis. 61
31427322 2019
11
Differential Lung Ventilation Using a Bronchial Blocker in a Pediatric Patient on Extracorporeal Membrane Oxygenation: A Case Report. 61
31162224 2019
12
Acquired neonatal bronchial stenosis after selective intubation: Successful managed with balloon dilatation. 61
31110714 2019
13
Predictors of outcome of prematurely born infants with pulmonary interstitial emphysema. 61
29754462 2019
14
Pulmonary cysts in smoking-related interstitial fibrosis: a form of pseudocyst secondary to pulmonary interstitial emphysema. 61
30269779 2018
15
Images in Anesthesiology: Persistent Pulmonary Interstitial Emphysema. 61
30234591 2018
16
Lobectomy with ECMO Support in an Infant Who Developed Pulmonary Interstitial Emphysema Following Repair of Hypoplastic Aortic Arch. 61
30517264 2018
17
Behavioral Characteristics and Medicolegal Identification of Infanticide. 61
30896108 2018
18
Pneumoperitoneum in a neonate weighing less than 500 g. What do we really know about it? 61
29769190 2018
19
Persistent Pulmonary Interstitial Emphysema. 61
29738327 2018
20
Early Pulmonary Interstitial Emphysema in Preterm Neonates-Respiratory Management and Case Report in Nonventilated Very Low Birth Weight Twins. 61
29765788 2018
21
Two Cases of Chloromethylisothiazolinone and Methylisothiazolinone-associated Toxic Lung Injury. 61
29651817 2018
22
Bilateral pulmonary interstitial emphysema in a preterm infant on continuous positive airway pressure: clinical and radiological correlation. 61
29743753 2018
23
Pulmonary interstitial emphysema in fatal asthma: case report and histopathological review. 61
29554886 2018
24
Pulmonary Barotrauma Including Huge Pulmonary Interstitial Emphysema in an Adult with Status Asthmaticus: Diagnostic and Therapeutic Challenges. 61
30756032 2018
25
Oxygen needs during resuscitation and surfactant to achieve stabilisation were independent risks factors for pulmonary interstitial emphysema in preterm infants. 61
28851119 2018
26
Application of Selective Bronchial Intubation versus Neurally Adjusted Ventilatory Assist in the Management of Unilateral Pulmonary Interstitial Emphysema: An Illustrative Case and the Literature Review. 61
28515969 2017
27
Pneumoperitoneum without Intestinal Perforation in a Neonate: Case Report and Literature Review. 61
28567320 2017
28
Humidifier disinfectant-associated lung injury in adults: Prognostic factors in predicting short-term outcome. 61
27147415 2017
29
Neonatal Pneumopericardium in a Nonventilated Term Infant: A Case Report and Review of the Literature. 61
29430316 2017
30
Presence of subpleural pulmonary interstitial emphysema as an indication of single or multiple alveolar ruptures on CT in patients with spontaneous pneumomediastinum. 61
26868169 2016
31
Steroid-induced resolution of refractory pulmonary interstitial emphysema. 61
26952563 2016
32
Bronchodilators for the prevention and treatment of chronic lung disease in preterm infants. 61
27960245 2016
33
Diffuse persistent pulmonary interstitial emphysema secondary to mechanical ventilation in bronchiolitis. 61
27809884 2016
34
A Case of Pulmonary Interstitial Emphysema Treated by Percutaneous Catheter Insertion in Extremely Low Birth Weight Infant. 61
27593885 2016
35
[Blunt chest trauma with pneumomediastinum and pneumoperitoneum secondary to Macklin effect. Case report]. 61
26769517 2016
36
Synchronized mechanical ventilation for respiratory support in newborn infants. 61
27581993 2016
37
Pulmonary interstitial emphysema due to respiratory syncytial virus infection. 61
27435178 2016
38
Synchronized mechanical ventilation for respiratory support in newborn infants. 61
27539719 2016
39
Nonsurgical management of an enlarging pneumatocele by fibrin sealant injection via pigtail catheter. 61
26340670 2016
40
Nasal Mask Versus Nasal Prongs for Delivering Nasal Continuous Positive Airway Pressure in Preterm Infants with Respiratory Distress: A Randomized Controlled Trial. 61
26713987 2015
41
Pulmonary interstitial emphysema following spirometry in CPFE syndrome. 61
26071368 2015
42
Pneumomediastinum, pneumorrhachis and subcutaneous emphysema associated with viral infections: Report of three cases. 61
26508192 2015
43
IMAGING DIAGNOSIS-SPONTANEOUS PNEUMOMEDIASTINUM SECONDARY TO PRIMARY PULMONARY PATHOLOGY IN A DALMATIAN DOG. 61
25388364 2015
44
Rare congenital pulmonary malformation with diagnostic challenging: congenital pulmonary lymphangiectasia, report of four autopsy cases and review of literature. 61
25142108 2015
45
Volume guarantee pressure support ventilation in extremely preterm infants and neurodevelopmental outcome at 18 months. 61
25569681 2015
46
Spontaneous Chest Wall Interstitial Emphysema Secondary to Chronic Empyema Thoracis. 61
26266188 2015
47
Lung ultrasound: a useful tool for the follow-up of neonatal localized interstitial emphysema. 61
25799192 2015
48
Perinatal conditions related to growth restriction and inflammation are associated with an increased risk of bronchopulmonary dysplasia. 61
25469645 2015
49
Elective high frequency oscillatory ventilation versus conventional ventilation for acute pulmonary dysfunction in preterm infants. 61
25785789 2015
50
A comparative study of honeycombing on high resolution computed tomography with histologic lung remodeling in explants with usual interstitial pneumonia. 61
25433993 2015

Variations for Interstitial Emphysema

Expression for Interstitial Emphysema

Search GEO for disease gene expression data for Interstitial Emphysema.

Pathways for Interstitial Emphysema

Pathways related to Interstitial Emphysema according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.43 SFTPD SFTPC SFTPB SFTPA1
2 11.12 SFTPC SFTPA1
3
Show member pathways
10.92 SFTPD SFTPA1
4
Show member pathways
10.65 SFTPD SFTPC SFTPB SFTPA1
5
Show member pathways
10.65 SFTPD SFTPC SFTPB SFTPA1 ABCA3

GO Terms for Interstitial Emphysema

Cellular components related to Interstitial Emphysema according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.88 TTN SFTPD SFTPC SFTPB SFTPA1 LY86
2 extracellular space GO:0005615 9.85 SFTPD SFTPC SFTPB SFTPA1 LY86 ABCA3
3 endoplasmic reticulum membrane GO:0005789 9.76 SFTPD SFTPC SFTPB SFTPA1
4 rough endoplasmic reticulum GO:0005791 9.43 SFTPD SFTPA1
5 multivesicular body GO:0005771 9.43 SFTPD SFTPB SFTPA1
6 lamellar body GO:0042599 9.33 SFTPC SFTPB SFTPA1
7 multivesicular body lumen GO:0097486 9.32 SFTPC SFTPB
8 alveolar lamellar body GO:0097208 9.13 SFTPC SFTPB ABCA3
9 clathrin-coated endocytic vesicle GO:0045334 8.92 SFTPD SFTPC SFTPB SFTPA1

Biological processes related to Interstitial Emphysema according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.35 SFTPD SFTPC SFTPB SFTPA1 ABCA3
2 toll-like receptor signaling pathway GO:0002224 9.26 SFTPD SFTPA1
3 developmental process GO:0032502 9.16 SFTPD SFTPA1
4 respiratory gaseous exchange GO:0007585 8.92 SFTPD SFTPC SFTPB SFTPA1

Molecular functions related to Interstitial Emphysema according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipid transporter activity GO:0005319 8.96 SFTPA1 ABCA3
2 monosaccharide binding GO:0048029 8.62 SFTPD SFTPA1

Sources for Interstitial Emphysema

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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