MCID: INT011
MIFTS: 38

Interstitial Emphysema

Categories: Respiratory diseases

Aliases & Classifications for Interstitial Emphysema

MalaCards integrated aliases for Interstitial Emphysema:

Name: Interstitial Emphysema 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:10030
ICD10 33 J98.2
ICD9CM 35 518.1
NCIt 50 C34571
SNOMED-CT 68 11211003 77690003
UMLS 73 C1370824

Summaries for Interstitial Emphysema

MalaCards based summary : Interstitial Emphysema is related to bronchopulmonary dysplasia and pneumothorax. An important gene associated with Interstitial Emphysema is LY96 (Lymphocyte Antigen 96), and among its related pathways/superpathways are Vemurafenib Pathway, Pharmacodynamics and Angiogenesis (CST). The drugs Pulmonary Surfactants and Respiratory System Agents have been mentioned in the context of this disorder. Affiliated tissues include lung, bone and heart, and related phenotypes are Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection after direct virus infection and Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection after viral supernatant infection

Related Diseases for Interstitial Emphysema

Diseases related to Interstitial Emphysema via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 80)
# Related Disease Score Top Affiliating Genes
1 bronchopulmonary dysplasia 29.6 FLT1 ELANE
2 pneumothorax 10.3
3 newborn respiratory distress syndrome 10.2
4 respiratory distress syndrome, infant 10.2
5 capillary lymphangioma 10.2 PROX1 HBA1
6 acquired hemangioma 10.2 PROX1 HBA1
7 angiokeratoma of fordyce 10.2 PROX1 HBA1
8 lymphatic malformations 10.2 PROX1 FLT4
9 hennekam syndrome 10.1 PROX1 FLT4
10 skin epithelioid hemangioma 10.1 HBA1 CD34
11 ovarian angiosarcoma 10.1 HBA1 CD34
12 ovary sarcoma 10.1 HBA1 CD34
13 intravascular fasciitis 10.1 HBA1 CD34
14 thyroid angiosarcoma 10.1 HBA1 CD34
15 pediatric angiosarcoma 10.1 HBA1 CD34
16 spleen angiosarcoma 10.1 HBA1 CD34
17 bone epithelioid hemangioma 10.1 HBA1 CD34
18 thyroid sarcoma 10.1 HBA1 CD34
19 asthma 10.1
20 hordeolum 10.1 HBA1 CD34
21 spleen cancer 10.1 HBA1 CD34
22 hemangioma of liver 10.1 HBA1 CD34
23 conventional angiosarcoma 10.1 HBA1 CD34
24 mixed liposarcoma 10.1 HBA1 CD34
25 venous hemangioma 10.1 HBA1 CD34
26 breast angiosarcoma 10.1 HBA1 CD34
27 erythema elevatum diutinum 10.1 HBA1 CD34
28 senile angioma 10.1 HBA1 CD34
29 malignant epithelioid hemangioendothelioma 10.1 FLT4 CD34
30 angiomyoma 10.1 HBA1 CD34
31 spindle cell liposarcoma 10.1 HBA1 CD34
32 chorioangioma 10.1 HBA1 CD34
33 vulvar sarcoma 10.1 TWIST1 CD34
34 mesenchymal cell neoplasm 10.1 HBA1 CD34
35 infiltrating lipoma 10.1 HBA1 CD34
36 lymphangioma 10.1 PROX1 HBA1 FLT4
37 hemangioma of intra-abdominal structure 10.1 HBA1 CD34
38 congenital epulis 10.0 HBA1 CD34
39 pulmonary emphysema 10.0
40 liver angiosarcoma 10.0 HBA1 CD34
41 capillary hemangioma 10.0 HBA1 FLT1
42 parametritis 10.0 LY96 LY86
43 robinow syndrome, autosomal recessive 10.0 TWIST1 SLC22A4
44 malignant hemangioma 10.0 FLT4 CD34
45 nephrogenic adenofibroma 10.0 HBA1 CD34
46 aleukemic leukemia cutis 10.0 ELANE CD34
47 kaposiform hemangioendothelioma 10.0 PROX1 FLT4 CD34
48 neurogenic bowel 10.0 LY96 LY86
49 skin hemangioma 10.0 PROX1 HBA1 FLT1
50 hobnail hemangioma 10.0 HBA1 FLT4 CD34

Comorbidity relations with Interstitial Emphysema via Phenotypic Disease Network (PDN):


Deficiency Anemia Familial Atrial Fibrillation
Heart Disease Postinflammatory Pulmonary Fibrosis
Respiratory Failure Spontaneous Tension Pneumothorax

Graphical network of the top 20 diseases related to Interstitial Emphysema:



Diseases related to Interstitial Emphysema

Symptoms & Phenotypes for Interstitial Emphysema

GenomeRNAi Phenotypes related to Interstitial Emphysema according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection after direct virus infection GR00233-A-2 9.13 FLT4 PROX1 TWIST1
2 Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection after viral supernatant infection GR00233-A-3 8.8 FLT4 PROX1 TWIST1

MGI Mouse Phenotypes related to Interstitial Emphysema:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.23 CD34 ELANE FLT1 FLT4 LY86 LY96

Drugs & Therapeutics for Interstitial Emphysema

Drugs for Interstitial Emphysema (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 41)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Pulmonary Surfactants Phase 4,Phase 2,Phase 3,Not Applicable
2 Respiratory System Agents Phase 4,Phase 2,Phase 3,Not Applicable
3 Adrenergic Agonists Phase 4
4 Anti-Asthmatic Agents Phase 4
5 Adrenergic beta-Agonists Phase 4
6 Adrenergic Agents Phase 4
7 Tocolytic Agents Phase 4
8 Adrenergic beta-2 Receptor Agonists Phase 4
9 Neurotransmitter Agents Phase 4
10 Peripheral Nervous System Agents Phase 4,Phase 3,Not Applicable
11 Bronchodilator Agents Phase 4
12 Pharmaceutical Solutions Phase 4
13 Autonomic Agents Phase 4,Phase 3
14 Albuterol Phase 4
15 Beractant Approved Phase 2, Phase 3 108778-82-1
16 Poractant alfa Approved Phase 2, Phase 3,Not Applicable 129069-19-8
17
Azithromycin Approved Phase 3,Phase 2 83905-01-5 55185 447043
18
Nitric Oxide Approved Phase 3 10102-43-9 145068
19
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3 1177-87-3
20
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
21 Vasoconstrictor Agents Phase 3
22
protease inhibitors Phase 3
23 Gastrointestinal Agents Phase 3
24 Anti-Inflammatory Agents Phase 3,Not Applicable
25 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
26 Hormone Antagonists Phase 3
27 Antineoplastic Agents, Hormonal Phase 3
28 Hormones Phase 3
29 BB 1101 Phase 3
30 glucocorticoids Phase 3
31 HIV Protease Inhibitors Phase 3
32 Antiemetics Phase 3
33
Ibuprofen Approved Not Applicable 15687-27-1 3672
34
Benzocaine Approved, Investigational Not Applicable 94-09-7, 1994-09-7 2337
35 tannic acid Approved Not Applicable
36 Calamus Not Applicable
37 Analgesics, Non-Narcotic Not Applicable
38 Analgesics Not Applicable
39 Cyclooxygenase Inhibitors Not Applicable
40 Anti-Inflammatory Agents, Non-Steroidal Not Applicable
41 Antirheumatic Agents Not Applicable

Interventional clinical trials:

(show all 20)
# Name Status NCT ID Phase Drugs
1 Surfactant Administration During Spontaneous Breathing Unknown status NCT01329432 Phase 4
2 Cpap at Delivery Room for Preterm Infants Unknown status NCT01024361 Phase 4
3 Nebulized 3% Hypertonic Saline Solution Treatment of Bronchiolitis in Infants Completed NCT02233985 Phase 4 0.9% Sodium Chloride;3% Sodium Chloride
4 A Multicenter, Randomized, Open Label Trial of a New Animal Extracted Surfactant to Treat RDS in Preterm Infants Completed NCT02305160 Phase 2, Phase 3 Butantan;Control
5 Mid and Standard Frequency Ventilation in Infants With Respiratory Distress Syndrome Recruiting NCT03231735 Phase 2, Phase 3
6 Phase III Randomized Study of Lucinactant in Full Term Newborn Infants With Meconium Aspiration Syndrome Terminated NCT00004500 Phase 3 Lucinactant
7 Minimal Breathing Support and Early Steroids to Prevent Chronic Lung Disease in Extremely Premature Infants (SAVE) Terminated NCT00005777 Phase 3 Dexamethasone;Placebo
8 TINN2: Treat Infection in NeoNates 2 Withdrawn NCT02282176 Phase 3 Azithromycin;Placebo
9 Trial of Intravenous Azithromycin to Eradicate Ureaplasma Respiratory Tract Infection in Preterm Infants Active, not recruiting NCT01778634 Phase 2 Azithromycin;Placebo
10 The Use of Heliox Via Nasal CPAP to Prevent Early CPAP Failure in Premature Infants: A Feasibility Study Completed NCT00739115 Not Applicable
11 Ventilatory Parameters and Inflammatory Responses of Neonates Ventilated by Different Modes of Ventilation Completed NCT01514331 Not Applicable
12 A Comparison of Methods of Discontinuing Nasal CPAP in Premature Infants <30 Weeks Gestation Recruiting NCT03292562 Not Applicable
13 Monitoring Neonatal Resuscitation Trial Recruiting NCT03256578 Not Applicable
14 Efficacy of a New Technique -"IN-REC-SUR-E"- in Preterm Neonates With RDS Recruiting NCT02482766 Not Applicable Poractant alfa, 200 mg/kg
15 Sustained Aeration of Infant Lungs Trial Active, not recruiting NCT02139800 Not Applicable
16 Comparison of Primary Extubation Failure Between NIPPV and NI-NAVA Active, not recruiting NCT03242057 Not Applicable
17 Non-invasive Respiratory Support in Preterm Infants Not yet recruiting NCT03512158 Not Applicable
18 Timing of PDA Closure and Respiratory Outcome in Premature Infants Terminated NCT00802685 Not Applicable Early ibuprofen
19 BEST (Burn Center Evaluation of Standard Therapies) Ventilator Mode Study- Terminated NCT00351741 Not Applicable
20 Nasal HFOV Versus Nasal CPAP to Reduce Post-extubation pCO2 Terminated NCT02340299 Not Applicable

Search NIH Clinical Center for Interstitial Emphysema

Genetic Tests for Interstitial Emphysema

Anatomical Context for Interstitial Emphysema

MalaCards organs/tissues related to Interstitial Emphysema:

41
Lung, Bone, Heart, Skin, Liver, Spleen, Thyroid

Publications for Interstitial Emphysema

Articles related to Interstitial Emphysema:

(show top 50) (show all 206)
# Title Authors Year
1
Persistent Pulmonary Interstitial Emphysema. ( 29738327 )
2018
2
Bilateral pulmonary interstitial emphysema in a preterm infant on continuous positive airway pressure: clinical and radiological correlation. ( 29743753 )
2018
3
Pulmonary interstitial emphysema in fatal asthma: case report and histopathological review. ( 29554886 )
2018
4
Predictors of outcome of prematurely born infants with pulmonary interstitial emphysema. ( 29754462 )
2018
5
Early Pulmonary Interstitial Emphysema in Preterm Neonates-Respiratory Management and Case Report in Nonventilated Very Low Birth Weight Twins. ( 29765788 )
2018
6
Images in Anesthesiology: Persistent Pulmonary Interstitial Emphysema. ( 30234591 )
2018
7
Pulmonary cysts in smoking-related interstitial fibrosis: a form of pseudocyst secondary to pulmonary interstitial emphysema. ( 30269779 )
2018
8
Lobectomy with ECMO Support in an Infant Who Developed Pulmonary Interstitial Emphysema Following Repair of Hypoplastic Aortic Arch. ( 30517264 )
2018
9
Oxygen needs during resuscitation and surfactant to achieve stabilisation were independent risks factors for pulmonary interstitial emphysema in preterm infants. ( 28851119 )
2017
10
Application of Selective Bronchial Intubation versus Neurally Adjusted Ventilatory Assist in the Management of Unilateral Pulmonary Interstitial Emphysema: An Illustrative Case and the Literature Review. ( 28515969 )
2017
11
Presence of subpleural pulmonary interstitial emphysema as an indication of single or multiple alveolar ruptures on CT in patients with spontaneous pneumomediastinum. ( 26868169 )
2016
12
Diffuse persistent pulmonary interstitial emphysema secondary to mechanical ventilation in bronchiolitis. ( 27809884 )
2016
13
Pulmonary interstitial emphysema due to respiratory syncytial virus infection. ( 27435178 )
2016
14
A Case of Pulmonary Interstitial Emphysema Treated by Percutaneous Catheter Insertion in Extremely Low Birth Weight Infant. ( 27593885 )
2016
15
Steroid-induced resolution of refractory pulmonary interstitial emphysema. ( 26952563 )
2016
16
Lung Ultrasound: A Useful Tool for the Follow-Up of Neonatal Localized Interstitial Emphysema. ( 25799192 )
2015
17
Pulmonary interstitial emphysema following spirometry in CPFE syndrome. ( 26071368 )
2015
18
Spontaneous Chest Wall Interstitial Emphysema Secondary to Chronic Empyema Thoracis. ( 26266188 )
2015
19
Development of Localized Pulmonary Interstitial Emphysema in a Late Preterm Infant without Mechanical Ventilation. ( 24744939 )
2014
20
Pulmonary interstitial emphysema in adults: a clinicopathologic study of 53 lung explants. ( 24525504 )
2014
21
Persistent pulmonary interstitial emphysema in a case of Langerhans cell histiocytosis. ( 25024518 )
2014
22
Pneumomediastinum and pulmonary interstitial emphysema after tracheal taser injury. ( 24057765 )
2013
23
Pulmonary interstitial emphysema after resolution of relapsing pneumothorax and discontinuation of mechanical ventilation. An atypical case in a preterm infant. ( 24245490 )
2013
24
Interstitial emphysema leading to pneumomediastinum in a bone marrow transplant patient. ( 23905536 )
2013
25
Severe Pulmonary Interstitial Emphysema in a Premature Baby. ( 24113884 )
2013
26
High-frequency oscillatory ventilation with low oscillatory frequency in pulmonary interstitial emphysema. ( 24060678 )
2013
27
Percutaneous evacuation of diffuse pulmonary interstitial emphysema by lung puncture in a baby with extremely low birth weight: a case report. ( 23013845 )
2012
28
Persistent pulmonary interstitial emphysema presenting as solitary lung cyst in a preterm infant. ( 23242093 )
2012
29
Complicated pulmonary interstitial emphysema. ( 21699043 )
2011
30
Pulmonary interstitial emphysema presenting in a woman on the intensive care unit: case report and review of literature. ( 21702976 )
2011
31
Pulmonary interstitial emphysema associated with recruitment manoeuvres on the adult intensive care unit. ( 21485692 )
2011
32
Pulmonary interstitial emphysema presenting as a congenital cystic adenomatous malformation on CT. ( 22009221 )
2011
33
Persistence of ventilatory defect after resolution of pulmonary interstitial emphysema in a preterm baby. ( 20540662 )
2010
34
Best cases from the AFIP: fatal 2009 influenza A (H1N1) infection, complicated by acute respiratory distress syndrome and pulmonary interstitial emphysema. ( 20068001 )
2010
35
Pulmonary interstitial emphysema complicating pneumonia in an unventilated term infant. ( 20799076 )
2010
36
Congenital pulmonary lymphangiectasis: report of an autopsy case masquerading as pulmonary interstitial emphysema. ( 20399027 )
2010
37
Pulmonary interstitial emphysema in an adult with metastatic choriocarcinoma. ( 27307875 )
2010
38
Persistent diffuse pulmonary interstitial emphysema mimicking pulmonary emphysema. ( 21686584 )
2009
39
Persistent diffuse pulmonary interstitial emphysema mimicking pulmonary emphysema. ( 21687099 )
2009
40
Imaging diagnosis--pulmonary interstitial emphysema in a dog. ( 19241759 )
2009
41
Combining heliox and inhaled nitric oxide as rescue treatment for pulmonary interstitial emphysema. ( 19558748 )
2009
42
Pulmonary lobar interstitial emphysema. ( 19842871 )
2009
43
Therapeutic lung puncture for diffuse unilateral pulmonary interstitial emphysema in preterm infants. ( 18704893 )
2008
44
Persistent pulmonary interstitial emphysema in a preterm infant. ( 18820387 )
2008
45
Spontaneous resolution of diffuse persistent pulmonary interstitial emphysema. ( 18433048 )
2008
46
Pulmonary interstitial emphysema and live birth. ( 19259033 )
2008
47
Combining medical gases in the treatment of pulmonary interstitial emphysema: novel, yes: but is it safe? ( 19025700 )
2008
48
Treatment of giant pulmonary interstitial emphysema by ipsilateral bronchial occlusion with a Swan-Ganz catheter. ( 17882412 )
2007
49
Persistent diffuse pulmonary interstitial emphysema mimicking pulmonary emphysema. ( 17600299 )
2007
50
Resolution of pulmonary interstitial emphysema following selective left main stem intubation in a premature newborn: an old procedure revisited. ( 17238893 )
2007

Variations for Interstitial Emphysema

Expression for Interstitial Emphysema

Search GEO for disease gene expression data for Interstitial Emphysema.

Pathways for Interstitial Emphysema

Pathways related to Interstitial Emphysema according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.88 FLT1 FLT4
2 10.75 FLT1 FLT4 PROX1
3 10.69 FLT1 TWIST1
4
Show member pathways
10.16 FLT1 FLT4

GO Terms for Interstitial Emphysema

Cellular components related to Interstitial Emphysema according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.17 CD34 ELANE FLT1 FLT4 HBA1 LY86

Biological processes related to Interstitial Emphysema according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to lipopolysaccharide GO:0032496 9.58 ABCC8 ELANE LY96
2 positive regulation of angiogenesis GO:0045766 9.54 CD34 FLT1 TWIST1
3 negative regulation of tumor necrosis factor production GO:0032720 9.48 CD34 TWIST1
4 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.46 FLT1 FLT4
5 blood vessel morphogenesis GO:0048514 9.43 FLT1 FLT4
6 vascular endothelial growth factor signaling pathway GO:0038084 9.32 FLT1 FLT4
7 lymph vessel development GO:0001945 9.26 FLT4 PROX1
8 lymphangiogenesis GO:0001946 9.16 FLT4 PROX1
9 positive regulation of lipopolysaccharide-mediated signaling pathway GO:0031666 8.96 LY86 LY96
10 positive regulation of tumor necrosis factor production GO:0032760 8.8 ABCC8 LY96 TWIST1

Molecular functions related to Interstitial Emphysema according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor binding GO:0019838 8.96 FLT1 FLT4
2 vascular endothelial growth factor-activated receptor activity GO:0005021 8.62 FLT1 FLT4

Sources for Interstitial Emphysema

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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