MCID: INT011
MIFTS: 34

Interstitial Emphysema

Categories: Respiratory diseases

Aliases & Classifications for Interstitial Emphysema

MalaCards integrated aliases for Interstitial Emphysema:

Name: Interstitial Emphysema 12 15 71 32

Classifications:



External Ids:

Disease Ontology 12 DOID:10030
ICD9CM 34 518.1
NCIt 49 C34571
SNOMED-CT 67 11211003 77690003
ICD10 32 J98.2
UMLS 71 C1370824

Summaries for Interstitial Emphysema

MalaCards based summary : Interstitial Emphysema is related to respiratory distress syndrome in premature infants and meconium aspiration syndrome. An important gene associated with Interstitial Emphysema is LY86 (Lymphocyte Antigen 86), and among its related pathways/superpathways are Surfactant metabolism and Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4). The drugs Ibuprofen and Anti-Inflammatory Agents have been mentioned in the context of this disorder. Affiliated tissues include lung, heart and neutrophil.

Related Diseases for Interstitial Emphysema

Diseases related to Interstitial Emphysema via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 65)
# Related Disease Score Top Affiliating Genes
1 respiratory distress syndrome in premature infants 29.8 SFTPC SFTPB ABCA3
2 meconium aspiration syndrome 29.6 TTN SLC22A4 SFTPB
3 lung disease 29.5 SFTPC SFTPB ABCA3
4 adult respiratory distress syndrome 29.2 SFTPC SFTPB
5 diaphragmatic hernia, congenital 29.1 SLC22A4 SFTPC SFTPB
6 pneumonia 29.1 SFTPC SFTPB LY96
7 idiopathic interstitial pneumonia 29.0 SFTPC SFTPB
8 respiratory failure 29.0 TTN SFTPC SFTPB ABCA3
9 newborn respiratory distress syndrome 29.0 TTN SLC22A4 SFTPC SFTPB ABCA3
10 interstitial lung disease 28.8 SFTPC SFTPB ABCA3
11 pulmonary fibrosis, idiopathic 28.6 SFTPC SFTPB ABCA3
12 pneumothorax 10.6
13 pulmonary emphysema 10.3
14 bronchopulmonary dysplasia 10.2
15 lymphangiectasis 10.2
16 pneumothorax, primary spontaneous 10.1
17 parametritis 10.1 LY96 LY86
18 scalp dermatosis 10.1 LY96 LY86
19 ventilation pneumonitis 10.1 SFTPB ABCA3
20 patent ductus arteriosus 1 10.1
21 surfactant metabolism dysfunction, pulmonary, 1 10.1 SFTPB ABCA3
22 internal hordeolum 10.0 LY96 LY86
23 neurotic disorder 10.0 LY96 LY86
24 constrictive pericarditis 10.0 WBP2NL TTN
25 bronchiolitis 10.0
26 pulmonary fibrosis 10.0
27 congestive heart failure 10.0
28 status asthmaticus 10.0
29 fibrosis of extraocular muscles, congenital, 1 9.8
30 laryngomalacia 9.8
31 cystic disease of lung 9.8
32 sudden infant death syndrome 9.8
33 asthma 9.8
34 langerhans cell histiocytosis 9.8
35 pulmonary disease, chronic obstructive 9.8
36 human immunodeficiency virus type 1 9.8
37 muscle hypertrophy 9.8
38 bacterial sepsis 9.8
39 cardiac arrest 9.8
40 asphyxia neonatorum 9.8
41 pertussis 9.8
42 heart disease 9.8
43 pneumatosis cystoides intestinalis 9.8
44 cystitis 9.8
45 histiocytosis 9.8
46 choriocarcinoma 9.8
47 pleural empyema 9.8
48 gastritis 9.8
49 appendicitis 9.8
50 measles 9.8

Comorbidity relations with Interstitial Emphysema via Phenotypic Disease Network (PDN):


Deficiency Anemia Familial Atrial Fibrillation
Heart Disease Postinflammatory Pulmonary Fibrosis
Respiratory Failure Spontaneous Tension Pneumothorax

Graphical network of the top 20 diseases related to Interstitial Emphysema:



Diseases related to Interstitial Emphysema

Symptoms & Phenotypes for Interstitial Emphysema

Drugs & Therapeutics for Interstitial Emphysema

Drugs for Interstitial Emphysema (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ibuprofen Approved 15687-27-1 3672
2 Anti-Inflammatory Agents
3 Anti-Inflammatory Agents, Non-Steroidal
4 Analgesics, Non-Narcotic
5 Analgesics
6 Cyclooxygenase Inhibitors
7 Antirheumatic Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 High Frequency Ventilation in Premature Infants (HIFI) Completed NCT00000567 Phase 3
2 Definition of the Status of the Human Lung Stem Cell Niches ex Vivo in Tissue Biopsies Performed in Patients With Emphysema and Interstitial Fibrosis Compared to Non-diseased Areas Unknown status NCT02705144
3 An Observational Study of Non Contrast Computed Tomography in Assessment of Regional Ventilation of the Lung. Recruiting NCT02879773
4 Palliative Care to Improve Quality of Life in CHF and COPD Recruiting NCT02713347
5 Timing of PDA Closure and Respiratory Outcome in Premature Infants Terminated NCT00802685 Early ibuprofen

Search NIH Clinical Center for Interstitial Emphysema

Genetic Tests for Interstitial Emphysema

Anatomical Context for Interstitial Emphysema

MalaCards organs/tissues related to Interstitial Emphysema:

40
Lung, Heart, Neutrophil, Bone Marrow, Bone, Brain, Fetal Lung

Publications for Interstitial Emphysema

Articles related to Interstitial Emphysema:

(show top 50) (show all 534)
# Title Authors PMID Year
1
CT features of pulmonary interstitial emphysema. 61
31053558 2019
2
Pulmonary interstitial emphysema is a risk factor for poor prognosis and a cause of air leaks. 61
31043328 2019
3
Neonate with persisting respiratory distress after resolution of pneumothorax. 61
31506322 2019
4
Positional treatment without mechanical ventilation in a very preterm infant with unilateral pulmonary interstitial emphysema: case report and review of the literature. 61
31370828 2019
5
Delivery room interventions to prevent bronchopulmonary dysplasia in preterm infants: a protocol for a systematic review and network meta-analysis. 61
31427322 2019
6
Differential Lung Ventilation Using a Bronchial Blocker in a Pediatric Patient on Extracorporeal Membrane Oxygenation: A Case Report. 61
31162224 2019
7
Acquired neonatal bronchial stenosis after selective intubation: Successful managed with balloon dilatation. 61
31110714 2019
8
Predictors of outcome of prematurely born infants with pulmonary interstitial emphysema. 61
29754462 2019
9
Images in Anesthesiology: Persistent Pulmonary Interstitial Emphysema. 61
30234591 2018
10
Pulmonary cysts in smoking-related interstitial fibrosis: a form of pseudocyst secondary to pulmonary interstitial emphysema. 61
30269779 2018
11
Lobectomy with ECMO Support in an Infant Who Developed Pulmonary Interstitial Emphysema Following Repair of Hypoplastic Aortic Arch. 61
30517264 2018
12
Behavioral Characteristics and Medicolegal Identification of Infanticide. 61
30896108 2018
13
Pneumoperitoneum in a neonate weighing less than 500 g. What do we really know about it? 61
29769190 2018
14
Persistent Pulmonary Interstitial Emphysema. 61
29738327 2018
15
Early Pulmonary Interstitial Emphysema in Preterm Neonates-Respiratory Management and Case Report in Nonventilated Very Low Birth Weight Twins. 61
29765788 2018
16
Two Cases of Chloromethylisothiazolinone and Methylisothiazolinone-associated Toxic Lung Injury. 61
29651817 2018
17
Bilateral pulmonary interstitial emphysema in a preterm infant on continuous positive airway pressure: clinical and radiological correlation. 61
29743753 2018
18
Pulmonary interstitial emphysema in fatal asthma: case report and histopathological review. 61
29554886 2018
19
Pulmonary Barotrauma Including Huge Pulmonary Interstitial Emphysema in an Adult with Status Asthmaticus: Diagnostic and Therapeutic Challenges. 61
30756032 2018
20
Oxygen needs during resuscitation and surfactant to achieve stabilisation were independent risks factors for pulmonary interstitial emphysema in preterm infants. 61
28851119 2018
21
Application of Selective Bronchial Intubation versus Neurally Adjusted Ventilatory Assist in the Management of Unilateral Pulmonary Interstitial Emphysema: An Illustrative Case and the Literature Review. 61
28515969 2017
22
Pneumoperitoneum without Intestinal Perforation in a Neonate: Case Report and Literature Review. 61
28567320 2017
23
Humidifier disinfectant-associated lung injury in adults: Prognostic factors in predicting short-term outcome. 61
27147415 2017
24
Neonatal Pneumopericardium in a Nonventilated Term Infant: A Case Report and Review of the Literature. 61
29430316 2017
25
Presence of subpleural pulmonary interstitial emphysema as an indication of single or multiple alveolar ruptures on CT in patients with spontaneous pneumomediastinum. 61
26868169 2016
26
Steroid-induced resolution of refractory pulmonary interstitial emphysema. 61
26952563 2016
27
Bronchodilators for the prevention and treatment of chronic lung disease in preterm infants. 61
27960245 2016
28
Diffuse persistent pulmonary interstitial emphysema secondary to mechanical ventilation in bronchiolitis. 61
27809884 2016
29
A Case of Pulmonary Interstitial Emphysema Treated by Percutaneous Catheter Insertion in Extremely Low Birth Weight Infant. 61
27593885 2016
30
[Blunt chest trauma with pneumomediastinum and pneumoperitoneum secondary to Macklin effect. Case report]. 61
26769517 2016
31
Synchronized mechanical ventilation for respiratory support in newborn infants. 61
27581993 2016
32
Pulmonary interstitial emphysema due to respiratory syncytial virus infection. 61
27435178 2016
33
Synchronized mechanical ventilation for respiratory support in newborn infants. 61
27539719 2016
34
Nonsurgical management of an enlarging pneumatocele by fibrin sealant injection via pigtail catheter. 61
26340670 2016
35
Nasal Mask Versus Nasal Prongs for Delivering Nasal Continuous Positive Airway Pressure in Preterm Infants with Respiratory Distress: A Randomized Controlled Trial. 61
26713987 2015
36
Pulmonary interstitial emphysema following spirometry in CPFE syndrome. 61
26071368 2015
37
Pneumomediastinum, pneumorrhachis and subcutaneous emphysema associated with viral infections: Report of three cases. 61
26508192 2015
38
IMAGING DIAGNOSIS-SPONTANEOUS PNEUMOMEDIASTINUM SECONDARY TO PRIMARY PULMONARY PATHOLOGY IN A DALMATIAN DOG. 61
25388364 2015
39
Rare congenital pulmonary malformation with diagnostic challenging: congenital pulmonary lymphangiectasia, report of four autopsy cases and review of literature. 61
25142108 2015
40
Volume guarantee pressure support ventilation in extremely preterm infants and neurodevelopmental outcome at 18 months. 61
25569681 2015
41
Spontaneous Chest Wall Interstitial Emphysema Secondary to Chronic Empyema Thoracis. 61
26266188 2015
42
Lung ultrasound: a useful tool for the follow-up of neonatal localized interstitial emphysema. 61
25799192 2015
43
Elective high frequency oscillatory ventilation versus conventional ventilation for acute pulmonary dysfunction in preterm infants. 61
25785789 2015
44
Perinatal conditions related to growth restriction and inflammation are associated with an increased risk of bronchopulmonary dysplasia. 61
25469645 2015
45
A comparative study of honeycombing on high resolution computed tomography with histologic lung remodeling in explants with usual interstitial pneumonia. 61
25433993 2015
46
Pneumomediastinum and pulmonary interstitial emphysema after tracheal taser injury. 61
24057765 2015
47
Risk Indicators for Air Leaks in Preterm Infants Exposed to Restrictive Use of Endotracheal Intubation. 61
25825229 2015
48
Surfactant for meconium aspiration syndrome in term and late preterm infants. 61
25504256 2014
49
Pulmonary interstitial emphysema after resolution of relapsing pneumothorax and discontinuation of mechanical ventilation. An atypical case in a preterm infant. 61
24245490 2014
50
Surgical salvage of acquired lung lesions in extremely premature infants. 61
24525614 2014

Variations for Interstitial Emphysema

Expression for Interstitial Emphysema

Search GEO for disease gene expression data for Interstitial Emphysema.

Pathways for Interstitial Emphysema

GO Terms for Interstitial Emphysema

Cellular components related to Interstitial Emphysema according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.72 SFTPC SFTPB LY96 LY86 ABCA3
2 clathrin-coated endocytic vesicle GO:0045334 9.26 SFTPC SFTPB
3 lamellar body GO:0042599 9.16 SFTPC SFTPB
4 multivesicular body lumen GO:0097486 8.96 SFTPC SFTPB
5 alveolar lamellar body GO:0097208 8.62 SFTPB ABCA3

Biological processes related to Interstitial Emphysema according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 respiratory gaseous exchange GO:0007585 9.16 SFTPC SFTPB
2 cellular protein metabolic process GO:0044267 9.13 SFTPC SFTPB ABCA3
3 positive regulation of lipopolysaccharide-mediated signaling pathway GO:0031666 8.62 LY96 LY86

Sources for Interstitial Emphysema

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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