MCID: INT011
MIFTS: 39

Interstitial Emphysema

Categories: Respiratory diseases

Aliases & Classifications for Interstitial Emphysema

MalaCards integrated aliases for Interstitial Emphysema:

Name: Interstitial Emphysema 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:10030
ICD10 33 J98.2
ICD9CM 35 518.1
NCIt 50 C34571
UMLS 73 C1370824

Summaries for Interstitial Emphysema

MalaCards based summary : Interstitial Emphysema is related to bronchopulmonary dysplasia and capillary lymphangioma. An important gene associated with Interstitial Emphysema is LY96 (Lymphocyte Antigen 96), and among its related pathways/superpathways are Vemurafenib Pathway, Pharmacodynamics and Angiogenesis (CST). The drugs Pulmonary Surfactants and Respiratory System Agents have been mentioned in the context of this disorder. Affiliated tissues include lung, fetal lung and heart, and related phenotypes are Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection after direct virus infection and immune system

Related Diseases for Interstitial Emphysema

Diseases related to Interstitial Emphysema via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 76)
# Related Disease Score Top Affiliating Genes
1 bronchopulmonary dysplasia 28.9 ELANE FLT1
2 capillary lymphangioma 10.7 HBA1 PROX1
3 acquired hemangioma 10.7 HBA1 PROX1
4 lymphatic malformations 10.7 FLT4 PROX1
5 angiokeratoma of fordyce 10.7 HBA1 PROX1
6 capillary hemangioma 10.6 HBA1 PROX1
7 skin hemangioma 10.6 HBA1 PROX1
8 hennekam syndrome 10.5 FLT4 PROX1
9 ovary sarcoma 10.4 CD34 HBA1
10 ovarian angiosarcoma 10.4 CD34 HBA1
11 intravascular fasciitis 10.4 CD34 HBA1
12 pediatric angiosarcoma 10.4 CD34 HBA1
13 thyroid angiosarcoma 10.4 CD34 HBA1
14 neurogenic arthropathy 10.4 CD34 HBA1
15 spleen angiosarcoma 10.4 CD34 HBA1
16 bone epithelioid hemangioma 10.4 CD34 HBA1
17 thyroid sarcoma 10.3 CD34 HBA1
18 hemangioma of liver 10.3 CD34 HBA1
19 extraosseous osteosarcoma 10.3 CD34 HBA1
20 spleen cancer 10.3 CD34 HBA1
21 breast angiosarcoma 10.3 CD34 HBA1
22 conventional angiosarcoma 10.3 CD34 HBA1
23 venous hemangioma 10.3 CD34 HBA1
24 mixed liposarcoma 10.3 CD34 HBA1
25 senile angioma 10.3 CD34 HBA1
26 lymphangioma 10.3 FLT4 HBA1 PROX1
27 angiomyoma 10.3 CD34 HBA1
28 chorioangioma 10.3 CD34 HBA1
29 spindle cell liposarcoma 10.3 CD34 HBA1
30 vulvar sarcoma 10.2 CD34 TWIST1
31 mesenchymal cell neoplasm 10.2 CD34 HBA1
32 pneumothorax 10.2
33 infiltrating lipoma 10.2 CD34 HBA1
34 hemangioma of intra-abdominal structure 10.2 CD34 HBA1
35 congenital epulis 10.1 CD34 HBA1
36 parametritis 10.1 LY86 LY96
37 newborn respiratory distress syndrome 10.1
38 respiratory distress syndrome, infant 10.1
39 liver angiosarcoma 10.1 CD34 HBA1
40 kaposiform hemangioendothelioma 10.1 CD34 FLT4 PROX1
41 cardiovascular organ benign neoplasm 10.1 CD34 HBA1
42 hemangioma 10.1 CD34 FLT4 PROX1
43 benign perivascular tumor 10.1 CD34 HBA1
44 aleukemic leukemia cutis 10.0 CD34 ELANE
45 neurogenic bowel 10.0 LY86 LY96
46 nephrogenic adenofibroma 10.0 CD34 HBA1
47 hobnail hemangioma 10.0 CD34 FLT4 HBA1
48 asthma 10.0
49 angiosarcoma 10.0 FLT1 FLT4 PROX1
50 glomangioma 10.0 CD34 HBA1

Comorbidity relations with Interstitial Emphysema via Phenotypic Disease Network (PDN):


Deficiency Anemia Familial Atrial Fibrillation
Heart Disease Postinflammatory Pulmonary Fibrosis
Respiratory Failure Spontaneous Tension Pneumothorax

Graphical network of the top 20 diseases related to Interstitial Emphysema:



Diseases related to Interstitial Emphysema

Symptoms & Phenotypes for Interstitial Emphysema

GenomeRNAi Phenotypes related to Interstitial Emphysema according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection after direct virus infection GR00233-A-2 8.8 FLT4 PROX1 TWIST1

MGI Mouse Phenotypes related to Interstitial Emphysema:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.23 CD34 ELANE FLT1 FLT4 LY86 LY96

Drugs & Therapeutics for Interstitial Emphysema

Drugs for Interstitial Emphysema (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 42)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Pulmonary Surfactants Phase 4,Phase 2,Phase 3,Not Applicable
2 Respiratory System Agents Phase 4,Phase 2,Phase 3,Not Applicable
3 Adrenergic Agents Phase 4
4 Adrenergic Agonists Phase 4
5 Adrenergic beta-2 Receptor Agonists Phase 4
6 Adrenergic beta-Agonists Phase 4
7 Albuterol Phase 4
8 Anti-Asthmatic Agents Phase 4
9 Autonomic Agents Phase 4,Phase 3
10 Bronchodilator Agents Phase 4
11 Neurotransmitter Agents Phase 4
12 Peripheral Nervous System Agents Phase 4,Phase 3,Not Applicable
13 Pharmaceutical Solutions Phase 4
14 Tocolytic Agents Phase 4
15 Beractant Approved Phase 2, Phase 3 108778-82-1
16 Poractant alfa Approved Phase 2, Phase 3,Not Applicable 129069-19-8
17
Azithromycin Approved Phase 3,Phase 2 83905-01-5 55185 447043
18
Nitric Oxide Approved Phase 3 10102-43-9 145068 160954
19
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
20 Vasoconstrictor Agents Phase 3
21 Antiemetics Phase 3
22 Anti-Inflammatory Agents Phase 3,Not Applicable
23 Antineoplastic Agents, Hormonal Phase 3
24 BB 1101 Phase 3
25 Dexamethasone acetate Phase 3 1177-87-3
26 Gastrointestinal Agents Phase 3
27 glucocorticoids Phase 3
28 HIV Protease Inhibitors Phase 3
29 Hormone Antagonists Phase 3
30 Hormones Phase 3
31 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
32
protease inhibitors Phase 3
33
Menthol Approved Not Applicable 2216-51-5 16666
34
Ibuprofen Approved Not Applicable 15687-27-1 3672
35
Benzocaine Approved, Investigational Not Applicable 1994-09-7, 94-09-7 2337
36 tannic acid Approved, Nutraceutical Not Applicable
37 Analgesics Not Applicable
38 Analgesics, Non-Narcotic Not Applicable
39 Anti-Inflammatory Agents, Non-Steroidal Not Applicable
40 Antirheumatic Agents Not Applicable
41 Cyclooxygenase Inhibitors Not Applicable
42 Calamus Nutraceutical Not Applicable

Interventional clinical trials:

(show all 20)
# Name Status NCT ID Phase Drugs
1 Surfactant Administration During Spontaneous Breathing Unknown status NCT01329432 Phase 4
2 Cpap at Delivery Room for Preterm Infants Unknown status NCT01024361 Phase 4
3 Nebulized 3% Hypertonic Saline Solution Treatment of Bronchiolitis in Infants Completed NCT02233985 Phase 4 0.9% Sodium Chloride;3% Sodium Chloride
4 A Multicenter, Randomized, Open Label Trial of a New Animal Extracted Surfactant to Treat RDS in Preterm Infants Completed NCT02305160 Phase 2, Phase 3 Butantan;Control
5 Mid and Standard Frequency Ventilation in Infants With Respiratory Distress Syndrome Recruiting NCT03231735 Phase 2, Phase 3
6 Phase III Randomized Study of Lucinactant in Full Term Newborn Infants With Meconium Aspiration Syndrome Terminated NCT00004500 Phase 3 Lucinactant
7 Minimal Breathing Support and Early Steroids to Prevent Chronic Lung Disease in Extremely Premature Infants (SAVE) Terminated NCT00005777 Phase 3 Dexamethasone;Placebo
8 TINN2: Treat Infection in NeoNates 2 Withdrawn NCT02282176 Phase 3 Azithromycin;Placebo
9 Trial of Intravenous Azithromycin to Eradicate Ureaplasma Respiratory Tract Infection in Preterm Infants Active, not recruiting NCT01778634 Phase 2 Azithromycin;Placebo
10 The Use of Heliox Via Nasal CPAP to Prevent Early CPAP Failure in Premature Infants: A Feasibility Study Completed NCT00739115 Not Applicable
11 Ventilatory Parameters and Inflammatory Responses of Neonates Ventilated by Different Modes of Ventilation Completed NCT01514331 Not Applicable
12 A Comparison of Methods of Discontinuing Nasal CPAP in Premature Infants <30 Weeks Gestation Recruiting NCT03292562 Not Applicable
13 Comparison of Primary Extubation Failure Between NIPPV and NI-NAVA Recruiting NCT03242057 Not Applicable
14 Monitoring Neonatal Resuscitation Trial Recruiting NCT03256578 Not Applicable
15 Efficacy of a New Technique -"IN-REC-SUR-E"- in Preterm Neonates With RDS Recruiting NCT02482766 Not Applicable Poractant alfa, 200 mg/kg
16 Sustained Aeration of Infant Lungs Trial Active, not recruiting NCT02139800 Not Applicable
17 Non-invasive Respiratory Support in Preterm Infants Not yet recruiting NCT03512158 Not Applicable
18 Timing of PDA Closure and Respiratory Outcome in Premature Infants Terminated NCT00802685 Not Applicable Early ibuprofen
19 BEST (Burn Center Evaluation of Standard Therapies) Ventilator Mode Study- Terminated NCT00351741 Not Applicable
20 Nasal HFOV Versus Nasal CPAP to Reduce Post-extubation pCO2 Terminated NCT02340299 Not Applicable

Search NIH Clinical Center for Interstitial Emphysema

Genetic Tests for Interstitial Emphysema

Anatomical Context for Interstitial Emphysema

MalaCards organs/tissues related to Interstitial Emphysema:

41
Lung, Fetal Lung, Heart, Bone, Bone Marrow

Publications for Interstitial Emphysema

Articles related to Interstitial Emphysema:

(show top 50) (show all 196)
# Title Authors Year
1
Persistent Pulmonary Interstitial Emphysema. ( 29738327 )
2018
2
Bilateral pulmonary interstitial emphysema in a preterm infant on continuous positive airway pressure: clinical and radiological correlation. ( 29743753 )
2018
3
Pulmonary interstitial emphysema in fatal asthma: case report and histopathological review. ( 29554886 )
2018
4
Predictors of outcome of prematurely born infants with pulmonary interstitial emphysema. ( 29754462 )
2018
5
Early Pulmonary Interstitial Emphysema in Preterm Neonates-Respiratory Management and Case Report in Nonventilated Very Low Birth Weight Twins. ( 29765788 )
2018
6
Oxygen needs during resuscitation and surfactant to achieve stabilisation were independent risks factors for pulmonary interstitial emphysema in preterm infants. ( 28851119 )
2017
7
Application of Selective Bronchial Intubation versus Neurally Adjusted Ventilatory Assist in the Management of Unilateral Pulmonary Interstitial Emphysema: An Illustrative Case and the Literature Review. ( 28515969 )
2017
8
Presence of subpleural pulmonary interstitial emphysema as an indication of single or multiple alveolar ruptures on CT in patients with spontaneous pneumomediastinum. ( 26868169 )
2016
9
Diffuse persistent pulmonary interstitial emphysema secondary to mechanical ventilation in bronchiolitis. ( 27809884 )
2016
10
Pulmonary interstitial emphysema due to respiratory syncytial virus infection. ( 27435178 )
2016
11
A Case of Pulmonary Interstitial Emphysema Treated by Percutaneous Catheter Insertion in Extremely Low Birth Weight Infant. ( 27593885 )
2016
12
Steroid-induced resolution of refractory pulmonary interstitial emphysema. ( 26952563 )
2016
13
Lung Ultrasound: A Useful Tool for the Follow-Up of Neonatal Localized Interstitial Emphysema. ( 25799192 )
2015
14
Pulmonary interstitial emphysema following spirometry in CPFE syndrome. ( 26071368 )
2015
15
Spontaneous Chest Wall Interstitial Emphysema Secondary to Chronic Empyema Thoracis. ( 26266188 )
2015
16
Development of Localized Pulmonary Interstitial Emphysema in a Late Preterm Infant without Mechanical Ventilation. ( 24744939 )
2014
17
Pulmonary interstitial emphysema in adults: a clinicopathologic study of 53 lung explants. ( 24525504 )
2014
18
Persistent pulmonary interstitial emphysema in a case of Langerhans cell histiocytosis. ( 25024518 )
2014
19
Pneumomediastinum and pulmonary interstitial emphysema after tracheal taser injury. ( 24057765 )
2013
20
Pulmonary interstitial emphysema after resolution of relapsing pneumothorax and discontinuation of mechanical ventilation. An atypical case in a preterm infant. ( 24245490 )
2013
21
Interstitial emphysema leading to pneumomediastinum in a bone marrow transplant patient. ( 23905536 )
2013
22
Severe Pulmonary Interstitial Emphysema in a Premature Baby. ( 24113884 )
2013
23
High-frequency oscillatory ventilation with low oscillatory frequency in pulmonary interstitial emphysema. ( 24060678 )
2013
24
Percutaneous evacuation of diffuse pulmonary interstitial emphysema by lung puncture in a baby with extremely low birth weight: a case report. ( 23013845 )
2012
25
Persistent pulmonary interstitial emphysema presenting as solitary lung cyst in a preterm infant. ( 23242093 )
2012
26
Complicated pulmonary interstitial emphysema. ( 21699043 )
2011
27
Pulmonary interstitial emphysema presenting in a woman on the intensive care unit: case report and review of literature. ( 21702976 )
2011
28
Pulmonary interstitial emphysema associated with recruitment manoeuvres on the adult intensive care unit. ( 21485692 )
2011
29
Pulmonary interstitial emphysema presenting as a congenital cystic adenomatous malformation on CT. ( 22009221 )
2011
30
Persistence of ventilatory defect after resolution of pulmonary interstitial emphysema in a preterm baby. ( 20540662 )
2010
31
Best cases from the AFIP: fatal 2009 influenza A (H1N1) infection, complicated by acute respiratory distress syndrome and pulmonary interstitial emphysema. ( 20068001 )
2010
32
Pulmonary interstitial emphysema complicating pneumonia in an unventilated term infant. ( 20799076 )
2010
33
Congenital pulmonary lymphangiectasis: report of an autopsy case masquerading as pulmonary interstitial emphysema. ( 20399027 )
2010
34
Persistent diffuse pulmonary interstitial emphysema mimicking pulmonary emphysema. ( 21686584 )
2009
35
Persistent diffuse pulmonary interstitial emphysema mimicking pulmonary emphysema. ( 21687099 )
2009
36
Imaging diagnosis--pulmonary interstitial emphysema in a dog. ( 19241759 )
2009
37
Combining heliox and inhaled nitric oxide as rescue treatment for pulmonary interstitial emphysema. ( 19558748 )
2009
38
Pulmonary lobar interstitial emphysema. ( 19842871 )
2009
39
Therapeutic lung puncture for diffuse unilateral pulmonary interstitial emphysema in preterm infants. ( 18704893 )
2008
40
Persistent pulmonary interstitial emphysema in a preterm infant. ( 18820387 )
2008
41
Spontaneous resolution of diffuse persistent pulmonary interstitial emphysema. ( 18433048 )
2008
42
Pulmonary interstitial emphysema and live birth. ( 19259033 )
2008
43
Treatment of giant pulmonary interstitial emphysema by ipsilateral bronchial occlusion with a Swan-Ganz catheter. ( 17882412 )
2007
44
Persistent diffuse pulmonary interstitial emphysema mimicking pulmonary emphysema. ( 17600299 )
2007
45
Resolution of pulmonary interstitial emphysema following selective left main stem intubation in a premature newborn: an old procedure revisited. ( 17238893 )
2007
46
Pulmonary interstitial emphysema in preterm twins on continuous positive airway pressure. ( 17118744 )
2006
47
Localized persistent pulmonary interstitial emphysema. ( 16769360 )
2006
48
Spontaneous pulmonary interstitial emphysema in a term unventilated infant. ( 16447182 )
2006
49
Risk factors and clinical outcomes of pulmonary interstitial emphysema in extremely low birth weight infants. ( 16493434 )
2006
50
Pulmonary interstitial emphysema in live birth determination: radiographic and gross pathologic features. ( 16423239 )
2006

Variations for Interstitial Emphysema

Expression for Interstitial Emphysema

Search GEO for disease gene expression data for Interstitial Emphysema.

Pathways for Interstitial Emphysema

Pathways related to Interstitial Emphysema according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.88 FLT1 FLT4
2 10.75 FLT1 FLT4 PROX1
3 10.69 FLT1 TWIST1
4
Show member pathways
10.16 FLT1 FLT4

GO Terms for Interstitial Emphysema

Cellular components related to Interstitial Emphysema according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.17 CD34 ELANE FLT1 FLT4 HBA1 LY86

Biological processes related to Interstitial Emphysema according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of angiogenesis GO:0045766 9.5 CD34 FLT1 TWIST1
2 negative regulation of tumor necrosis factor production GO:0032720 9.46 CD34 TWIST1
3 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.43 FLT1 FLT4
4 sprouting angiogenesis GO:0002040 9.4 FLT1 FLT4
5 blood vessel morphogenesis GO:0048514 9.37 FLT1 FLT4
6 lymph vessel development GO:0001945 9.26 FLT4 PROX1
7 lymphangiogenesis GO:0001946 9.16 FLT4 PROX1
8 vascular endothelial growth factor signaling pathway GO:0038084 8.96 FLT1 FLT4
9 positive regulation of lipopolysaccharide-mediated signaling pathway GO:0031666 8.62 LY86 LY96

Molecular functions related to Interstitial Emphysema according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 vascular endothelial growth factor-activated receptor activity GO:0005021 8.62 FLT1 FLT4

Sources for Interstitial Emphysema

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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