MCID: INT011
MIFTS: 39

Interstitial Emphysema

Categories: Respiratory diseases

Aliases & Classifications for Interstitial Emphysema

MalaCards integrated aliases for Interstitial Emphysema:

Name: Interstitial Emphysema 12 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:10030
ICD9CM 36 518.1
NCIt 51 C34571
SNOMED-CT 69 11211003 77690003
ICD10 34 J98.2
UMLS 74 C1370824

Summaries for Interstitial Emphysema

MalaCards based summary : Interstitial Emphysema is related to bronchopulmonary dysplasia and pneumothorax. An important gene associated with Interstitial Emphysema is LY96 (Lymphocyte Antigen 96), and among its related pathways/superpathways are Angiogenesis (CST) and Vemurafenib Pathway, Pharmacodynamics. The drugs Pulmonary Surfactants and Respiratory System Agents have been mentioned in the context of this disorder. Affiliated tissues include lung, bone and heart, and related phenotypes are Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection after direct virus infection and immune system

Related Diseases for Interstitial Emphysema

Diseases related to Interstitial Emphysema via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 54)
# Related Disease Score Top Affiliating Genes
1 bronchopulmonary dysplasia 29.6 ELANE FLT1
2 pneumothorax 10.3
3 lymphatic malformations 10.3 FLT4 PROX1
4 hemangioendothelioma 10.3 FLT4 PECAM1
5 respiratory distress syndrome in premature infants 10.2
6 newborn respiratory distress syndrome 10.2
7 respiratory distress syndrome, infant 10.2
8 hennekam syndrome 10.2 FLT4 PROX1
9 hydrocele 10.2 FLT4 PECAM1
10 skin hemangioma 10.2 FLT1 PROX1
11 lymphangioma 10.1 FLT4 PROX1
12 parametritis 10.1 LY86 LY96
13 asthma 10.1
14 hobnail hemangioma 10.1 CD34 FLT4
15 erythema elevatum diutinum 10.1 CD34 PECAM1
16 malignant epithelioid hemangioendothelioma 10.1 CD34 FLT4
17 neurogenic bowel 10.1 LY86 LY96
18 capillary hemangioma 10.1 FLT1 PECAM1
19 vulvar sarcoma 10.1 CD34 TWIST1
20 pulmonary emphysema 10.1
21 niemann-pick disease, type c2 10.0 LY86 LY96
22 robinow syndrome, autosomal recessive 10.0 SLC22A4 TWIST1
23 glomeruloid hemangioma 10.0 CD34 FLT1
24 malignant hemangioma 10.0 CD34 FLT4
25 aleukemic leukemia cutis 10.0 CD34 ELANE
26 lymphangiosarcoma 10.0 CD34 FLT4 PROX1
27 pneumonia 10.0
28 lymphangiectasis 10.0
29 breast carcinoma in situ 9.9 FLT1 FLT4
30 diaphragmatic hernia, congenital 9.8
31 acute insulin response 9.8
32 langerhans cell histiocytosis 9.8
33 adult respiratory distress syndrome 9.8
34 pertussis 9.8
35 heart disease 9.8
36 pneumatosis cystoides intestinalis 9.8
37 cystitis 9.8
38 bronchiolitis 9.8
39 histiocytosis 9.8
40 choriocarcinoma 9.8
41 pleural empyema 9.8
42 appendicitis 9.8
43 influenza 9.8
44 lung disease 9.8
45 measles 9.8
46 status asthmaticus 9.8
47 acute respiratory distress syndrome 9.8
48 combined pulmonary fibrosis-emphysema syndrome 9.8
49 kaposiform hemangioendothelioma 9.8 CD34 FLT4 PECAM1 PROX1
50 angiosarcoma 9.8 FLT1 FLT4 PECAM1 PROX1

Comorbidity relations with Interstitial Emphysema via Phenotypic Disease Network (PDN):


Deficiency Anemia Familial Atrial Fibrillation
Heart Disease Postinflammatory Pulmonary Fibrosis
Respiratory Failure Spontaneous Tension Pneumothorax

Graphical network of the top 20 diseases related to Interstitial Emphysema:



Diseases related to Interstitial Emphysema

Symptoms & Phenotypes for Interstitial Emphysema

GenomeRNAi Phenotypes related to Interstitial Emphysema according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection after direct virus infection GR00233-A-2 8.8 FLT4 PROX1 TWIST1

MGI Mouse Phenotypes related to Interstitial Emphysema:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.28 CD34 ELANE FLT1 FLT4 LY86 LY96

Drugs & Therapeutics for Interstitial Emphysema

Drugs for Interstitial Emphysema (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 41)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Pulmonary Surfactants Phase 4,Phase 2,Phase 3,Not Applicable
2 Respiratory System Agents Phase 4,Phase 2,Phase 3,Not Applicable
3 Adrenergic beta-Agonists Phase 4
4 Tocolytic Agents Phase 4
5 Adrenergic beta-2 Receptor Agonists Phase 4
6 Adrenergic Agonists Phase 4
7 Adrenergic Agents Phase 4
8 Neurotransmitter Agents Phase 4
9 Peripheral Nervous System Agents Phase 4,Phase 3,Not Applicable
10 Bronchodilator Agents Phase 4
11 Anti-Asthmatic Agents Phase 4
12 Autonomic Agents Phase 4,Phase 3
13 Pharmaceutical Solutions Phase 4
14 Albuterol Phase 4
15 Beractant Approved Phase 2, Phase 3 108778-82-1
16 Poractant alfa Approved Phase 2, Phase 3,Not Applicable 129069-19-8
17
Azithromycin Approved Phase 3,Phase 2 83905-01-5 447043 55185
18
Nitric Oxide Approved Phase 3 10102-43-9 145068
19
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
20
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3 1177-87-3
21 Vasoconstrictor Agents Phase 3
22 Gastrointestinal Agents Phase 3
23 Hormones Phase 3
24 HIV Protease Inhibitors Phase 3
25 Antineoplastic Agents, Hormonal Phase 3
26 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
27 Antiemetics Phase 3
28
protease inhibitors Phase 3
29 glucocorticoids Phase 3
30 Anti-Inflammatory Agents Phase 3,Not Applicable
31 BB 1101 Phase 3
32 Hormone Antagonists Phase 3
33
Ibuprofen Approved Not Applicable 15687-27-1 3672
34
tannic acid Approved Not Applicable 1401-55-4
35
Benzocaine Approved, Investigational Not Applicable 1994-09-7, 94-09-7 2337
36 Calamus Not Applicable
37 Anti-Inflammatory Agents, Non-Steroidal Not Applicable
38 Analgesics Not Applicable
39 Cyclooxygenase Inhibitors Not Applicable
40 Analgesics, Non-Narcotic Not Applicable
41 Antirheumatic Agents Not Applicable

Interventional clinical trials:

(show all 21)
# Name Status NCT ID Phase Drugs
1 Surfactant Administration During Spontaneous Breathing Unknown status NCT01329432 Phase 4
2 Cpap at Delivery Room for Preterm Infants Unknown status NCT01024361 Phase 4
3 Nebulized 3% Hypertonic Saline Solution Treatment of Bronchiolitis in Infants Completed NCT02233985 Phase 4 0.9% Sodium Chloride;3% Sodium Chloride
4 A Multicenter, Randomized, Open Label Trial of a New Animal Extracted Surfactant to Treat RDS in Preterm Infants Completed NCT02305160 Phase 2, Phase 3 Butantan;Control
5 Surfactant Positive Airway Pressure and Pulse Oximetry Trial Completed NCT00233324 Phase 3 Surfactant;Supplemental oxygen with target saturation of 85 to 89%;Supplemental oxygen with target saturation of 91 to 95%
6 Mid and Standard Frequency Ventilation in Infants With Respiratory Distress Syndrome Recruiting NCT03231735 Phase 2, Phase 3
7 Phase III Randomized Study of Lucinactant in Full Term Newborn Infants With Meconium Aspiration Syndrome Terminated NCT00004500 Phase 3 Lucinactant
8 Minimal Breathing Support and Early Steroids to Prevent Chronic Lung Disease in Extremely Premature Infants (SAVE) Terminated NCT00005777 Phase 3 Dexamethasone;Placebo
9 TINN2: Treat Infection in NeoNates 2 Withdrawn NCT02282176 Phase 3 Azithromycin;Placebo
10 Trial of Intravenous Azithromycin to Eradicate Ureaplasma Respiratory Tract Infection in Preterm Infants Active, not recruiting NCT01778634 Phase 2 Azithromycin;Placebo
11 A Comparison of Methods of Discontinuing Nasal CPAP in Premature Infants <30 Weeks Gestation Completed NCT03292562 Not Applicable
12 The Use of Heliox Via Nasal CPAP to Prevent Early CPAP Failure in Premature Infants: A Feasibility Study Completed NCT00739115 Not Applicable
13 Ventilatory Parameters and Inflammatory Responses of Neonates Ventilated by Different Modes of Ventilation Completed NCT01514331 Not Applicable
14 Efficacy of a New Technique -"IN-REC-SUR-E"- in Preterm Neonates With RDS Completed NCT02482766 Not Applicable Poractant alfa, 200 mg/kg
15 Monitoring Neonatal Resuscitation Trial Recruiting NCT03256578 Not Applicable
16 Sustained Aeration of Infant Lungs Trial Active, not recruiting NCT02139800 Not Applicable
17 Comparison of Primary Extubation Failure Between NIPPV and NI-NAVA Active, not recruiting NCT03242057 Not Applicable
18 Non-invasive Respiratory Support in Preterm Infants Not yet recruiting NCT03512158 Not Applicable
19 Timing of PDA Closure and Respiratory Outcome in Premature Infants Terminated NCT00802685 Not Applicable Early ibuprofen
20 BEST (Burn Center Evaluation of Standard Therapies) Ventilator Mode Study- Terminated NCT00351741 Not Applicable
21 Nasal HFOV Versus Nasal CPAP to Reduce Post-extubation pCO2 Terminated NCT02340299 Not Applicable

Search NIH Clinical Center for Interstitial Emphysema

Genetic Tests for Interstitial Emphysema

Anatomical Context for Interstitial Emphysema

MalaCards organs/tissues related to Interstitial Emphysema:

42
Lung, Bone, Heart, Bone Marrow, Fetal Lung, Skin

Publications for Interstitial Emphysema

Articles related to Interstitial Emphysema:

(show top 50) (show all 209)
# Title Authors Year
1
Pulmonary interstitial emphysema is a risk factor for poor prognosis and a cause of air leaks. ( 31043328 )
2019
2
CT features of pulmonary interstitial emphysema. ( 31053558 )
2019
3
Oxygen needs during resuscitation and surfactant to achieve stabilisation were independent risks factors for pulmonary interstitial emphysema in preterm infants. ( 28851119 )
2018
4
Pulmonary interstitial emphysema in fatal asthma: case report and histopathological review. ( 29554886 )
2018
5
Persistent Pulmonary Interstitial Emphysema. ( 29738327 )
2018
6
Bilateral pulmonary interstitial emphysema in a preterm infant on continuous positive airway pressure: clinical and radiological correlation. ( 29743753 )
2018
7
Predictors of outcome of prematurely born infants with pulmonary interstitial emphysema. ( 29754462 )
2018
8
Early Pulmonary Interstitial Emphysema in Preterm Neonates-Respiratory Management and Case Report in Nonventilated Very Low Birth Weight Twins. ( 29765788 )
2018
9
Images in Anesthesiology: Persistent Pulmonary Interstitial Emphysema. ( 30234591 )
2018
10
Pulmonary cysts in smoking-related interstitial fibrosis: a form of pseudocyst secondary to pulmonary interstitial emphysema. ( 30269779 )
2018
11
Lobectomy with ECMO Support in an Infant Who Developed Pulmonary Interstitial Emphysema Following Repair of Hypoplastic Aortic Arch. ( 30517264 )
2018
12
Pulmonary Barotrauma Including Huge Pulmonary Interstitial Emphysema in an Adult with Status Asthmaticus: Diagnostic and Therapeutic Challenges. ( 30756032 )
2018
13
Application of Selective Bronchial Intubation versus Neurally Adjusted Ventilatory Assist in the Management of Unilateral Pulmonary Interstitial Emphysema: An Illustrative Case and the Literature Review. ( 28515969 )
2017
14
Diffuse persistent pulmonary interstitial emphysema secondary to mechanical ventilation in bronchiolitis. ( 27809884 )
2016
15
Presence of subpleural pulmonary interstitial emphysema as an indication of single or multiple alveolar ruptures on CT in patients with spontaneous pneumomediastinum. ( 26868169 )
2016
16
Steroid-induced resolution of refractory pulmonary interstitial emphysema. ( 26952563 )
2016
17
Pulmonary interstitial emphysema due to respiratory syncytial virus infection. ( 27435178 )
2016
18
A Case of Pulmonary Interstitial Emphysema Treated by Percutaneous Catheter Insertion in Extremely Low Birth Weight Infant. ( 27593885 )
2016
19
Pneumomediastinum and pulmonary interstitial emphysema after tracheal taser injury. ( 24057765 )
2015
20
Lung ultrasound: a useful tool for the follow-up of neonatal localized interstitial emphysema. ( 25799192 )
2015
21
Pulmonary interstitial emphysema following spirometry in CPFE syndrome. ( 26071368 )
2015
22
Spontaneous Chest Wall Interstitial Emphysema Secondary to Chronic Empyema Thoracis. ( 26266188 )
2015
23
Persistent pulmonary interstitial emphysema in a case of Langerhans cell histiocytosis. ( 25024518 )
2014
24
Severe pulmonary interstitial emphysema in a premature baby. ( 24113884 )
2014
25
Pulmonary interstitial emphysema after resolution of relapsing pneumothorax and discontinuation of mechanical ventilation. An atypical case in a preterm infant. ( 24245490 )
2014
26
Pulmonary interstitial emphysema in adults: a clinicopathologic study of 53 lung explants. ( 24525504 )
2014
27
Development of Localized Pulmonary Interstitial Emphysema in a Late Preterm Infant without Mechanical Ventilation. ( 24744939 )
2014
28
Interstitial emphysema leading to pneumomediastinum in a bone marrow transplant patient. ( 23905536 )
2013
29
High-frequency oscillatory ventilation with low oscillatory frequency in pulmonary interstitial emphysema. ( 24060678 )
2013
30
Percutaneous evacuation of diffuse pulmonary interstitial emphysema by lung puncture in a baby with extremely low birth weight: a case report. ( 23013845 )
2012
31
Persistent pulmonary interstitial emphysema presenting as solitary lung cyst in a preterm infant. ( 23242093 )
2012
32
Pulmonary interstitial emphysema associated with recruitment manoeuvres on the adult intensive care unit. ( 21485692 )
2011
33
Complicated pulmonary interstitial emphysema. ( 21699043 )
2011
34
Pulmonary interstitial emphysema presenting in a woman on the intensive care unit: case report and review of literature. ( 21702976 )
2011
35
Pulmonary interstitial emphysema presenting as a congenital cystic adenomatous malformation on CT. ( 22009221 )
2011
36
Best cases from the AFIP: fatal 2009 influenza A (H1N1) infection, complicated by acute respiratory distress syndrome and pulmonary interstitial emphysema. ( 20068001 )
2010
37
Pulmonary interstitial emphysema in an adult with metastatic choriocarcinoma. ( 27307875 )
2010
38
Congenital pulmonary lymphangiectasis: report of an autopsy case masquerading as pulmonary interstitial emphysema. ( 20399027 )
2010
39
Persistence of ventilatory defect after resolution of pulmonary interstitial emphysema in a preterm baby. ( 20540662 )
2010
40
Pulmonary interstitial emphysema complicating pneumonia in an unventilated term infant. ( 20799076 )
2010
41
Imaging diagnosis--pulmonary interstitial emphysema in a dog. ( 19241759 )
2009
42
Combining heliox and inhaled nitric oxide as rescue treatment for pulmonary interstitial emphysema. ( 19558748 )
2009
43
Pulmonary lobar interstitial emphysema. ( 19842871 )
2009
44
Persistent diffuse pulmonary interstitial emphysema mimicking pulmonary emphysema. ( 21686584 )
2009
45
Persistent diffuse pulmonary interstitial emphysema mimicking pulmonary emphysema. ( 21687099 )
2009
46
Spontaneous resolution of diffuse persistent pulmonary interstitial emphysema. ( 18433048 )
2008
47
Therapeutic lung puncture for diffuse unilateral pulmonary interstitial emphysema in preterm infants. ( 18704893 )
2008
48
Persistent pulmonary interstitial emphysema in a preterm infant. ( 18820387 )
2008
49
Combining medical gases in the treatment of pulmonary interstitial emphysema: novel, yes: but is it safe? ( 19025700 )
2008
50
Pulmonary interstitial emphysema and live birth. ( 19259033 )
2008

Variations for Interstitial Emphysema

Expression for Interstitial Emphysema

Search GEO for disease gene expression data for Interstitial Emphysema.

Pathways for Interstitial Emphysema

Pathways related to Interstitial Emphysema according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.87 FLT1 FLT4 PECAM1 PROX1
2 10.79 FLT1 FLT4
3 10.49 FLT1 TWIST1

GO Terms for Interstitial Emphysema

Cellular components related to Interstitial Emphysema according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.43 APELA ELANE FLT1 LY86 LY96 PECAM1
2 extracellular region GO:0005576 9.17 APELA CD34 ELANE FLT1 FLT4 LY86

Biological processes related to Interstitial Emphysema according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.71 APELA FLT1 FLT4
2 leukocyte migration GO:0050900 9.67 CD34 ELANE PECAM1
3 response to lipopolysaccharide GO:0032496 9.63 ABCC8 ELANE LY96
4 angiogenesis GO:0001525 9.56 APELA FLT1 FLT4 PECAM1
5 negative regulation of tumor necrosis factor production GO:0032720 9.52 CD34 TWIST1
6 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.51 FLT1 FLT4
7 blood vessel morphogenesis GO:0048514 9.48 FLT1 FLT4
8 vascular endothelial growth factor signaling pathway GO:0038084 9.43 FLT1 FLT4
9 lymph vessel development GO:0001945 9.4 FLT4 PROX1
10 lymphangiogenesis GO:0001946 9.37 FLT4 PROX1
11 positive regulation of tumor necrosis factor production GO:0032760 9.33 ABCC8 LY96 TWIST1
12 positive regulation of lipopolysaccharide-mediated signaling pathway GO:0031666 9.32 LY86 LY96
13 glomerular endothelium development GO:0072011 8.96 CD34 PECAM1
14 positive regulation of angiogenesis GO:0045766 8.92 APELA CD34 FLT1 TWIST1

Molecular functions related to Interstitial Emphysema according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 vascular endothelial growth factor-activated receptor activity GO:0005021 8.62 FLT1 FLT4

Sources for Interstitial Emphysema

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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