MCID: INT011
MIFTS: 39

Interstitial Emphysema

Categories: Respiratory diseases

Aliases & Classifications for Interstitial Emphysema

MalaCards integrated aliases for Interstitial Emphysema:

Name: Interstitial Emphysema 12 15 72 33

Classifications:



External Ids:

Disease Ontology 12 DOID:10030
ICD9CM 35 518.1
NCIt 50 C34571
SNOMED-CT 68 11211003 77690003
ICD10 33 J98.2
UMLS 72 C1370824

Summaries for Interstitial Emphysema

MalaCards based summary : Interstitial Emphysema is related to bronchopulmonary dysplasia and pneumothorax. An important gene associated with Interstitial Emphysema is LY96 (Lymphocyte Antigen 96), and among its related pathways/superpathways are VEGF Pathway (Qiagen) and Angiogenesis (CST). The drugs Ibuprofen and Analgesics have been mentioned in the context of this disorder. Affiliated tissues include lung, heart and neutrophil, and related phenotypes are homeostasis/metabolism and hematopoietic system

Related Diseases for Interstitial Emphysema

Diseases related to Interstitial Emphysema via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 73)
# Related Disease Score Top Affiliating Genes
1 bronchopulmonary dysplasia 29.8 FLT1 ELANE
2 pneumothorax 10.6
3 respiratory distress syndrome in premature infants 10.4
4 newborn respiratory distress syndrome 10.4
5 lymphatic malformations 10.3 PROX1 FLT4
6 pulmonary emphysema 10.3
7 lung disease 10.3
8 hemangioendothelioma 10.3 PECAM1 FLT4
9 respiratory failure 10.2
10 hennekam syndrome 10.2 PROX1 FLT4
11 lymphangiectasis 10.2
12 lymphangioma 10.2 PROX1 FLT4
13 pneumothorax, primary spontaneous 10.1
14 hydrocele 10.1 PECAM1 FLT4
15 erythema elevatum diutinum 10.1 PECAM1 CD34
16 skin hemangioma 10.1 PROX1 FLT1
17 hobnail hemangioma 10.1 FLT4 CD34
18 malignant epithelioid hemangioendothelioma 10.1 FLT4 CD34
19 patent ductus arteriosus 1 10.1
20 parametritis 10.0 LY96 LY86
21 capillary hemangioma 10.0 PECAM1 FLT1
22 adult respiratory distress syndrome 10.0
23 idiopathic interstitial pneumonia 10.0
24 bronchiolitis 10.0
25 pulmonary fibrosis 10.0
26 pneumonia 10.0
27 congestive heart failure 10.0
28 status asthmaticus 10.0
29 acute respiratory distress syndrome 10.0
30 glomeruloid hemangioma 9.9 FLT1 CD34
31 aleukemic leukemia cutis 9.9 ELANE CD34
32 neurogenic bowel 9.9 LY96 LY86
33 malignant hemangioma 9.9 FLT4 CD34
34 lymphangiosarcoma 9.8 PROX1 FLT4 CD34
35 fibrosis of extraocular muscles, congenital, 1 9.8
36 diaphragmatic hernia, congenital 9.8
37 laryngomalacia 9.8
38 pulmonary fibrosis, idiopathic 9.8
39 cystic disease of lung 9.8
40 sudden infant death syndrome 9.8
41 asthma 9.8
42 langerhans cell histiocytosis 9.8
43 pulmonary disease, chronic obstructive 9.8
44 human immunodeficiency virus type 1 9.8
45 muscle hypertrophy 9.8
46 bacterial sepsis 9.8
47 cardiac arrest 9.8
48 meconium aspiration syndrome 9.8
49 asphyxia neonatorum 9.8
50 pertussis 9.8

Comorbidity relations with Interstitial Emphysema via Phenotypic Disease Network (PDN):


Deficiency Anemia Familial Atrial Fibrillation
Heart Disease Postinflammatory Pulmonary Fibrosis
Respiratory Failure Spontaneous Tension Pneumothorax

Graphical network of the top 20 diseases related to Interstitial Emphysema:



Diseases related to Interstitial Emphysema

Symptoms & Phenotypes for Interstitial Emphysema

MGI Mouse Phenotypes related to Interstitial Emphysema:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.81 ABCC8 CD34 ELANE FLT1 FLT4 PECAM1
2 hematopoietic system MP:0005397 9.8 CD34 ELANE FLT1 LY86 LY96 PECAM1
3 immune system MP:0005387 9.61 CD34 ELANE FLT1 FLT4 LY86 LY96
4 muscle MP:0005369 9.02 FLT1 FLT4 PECAM1 PROX1 TTPA

Drugs & Therapeutics for Interstitial Emphysema

Drugs for Interstitial Emphysema (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ibuprofen Approved 15687-27-1 3672
2 Analgesics
3 Anti-Inflammatory Agents
4 Analgesics, Non-Narcotic
5 Cyclooxygenase Inhibitors
6 Anti-Inflammatory Agents, Non-Steroidal
7 Peripheral Nervous System Agents
8 Antirheumatic Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 High Frequency Ventilation in Premature Infants (HIFI) Completed NCT00000567 Phase 3
2 Definition of the Status of the Human Lung Stem Cell Niches ex Vivo in Tissue Biopsies Performed in Patients With Emphysema and Interstitial Fibrosis Compared to Non-diseased Areas Unknown status NCT02705144
3 Timing of PDA Closure and Respiratory Outcome in Premature Infants Terminated NCT00802685 Early ibuprofen

Search NIH Clinical Center for Interstitial Emphysema

Genetic Tests for Interstitial Emphysema

Anatomical Context for Interstitial Emphysema

MalaCards organs/tissues related to Interstitial Emphysema:

41
Lung, Heart, Neutrophil, Brain, Bone, Bone Marrow, Fetal Lung

Publications for Interstitial Emphysema

Articles related to Interstitial Emphysema:

(show top 50) (show all 533)
# Title Authors PMID Year
1
Delivery room interventions to prevent bronchopulmonary dysplasia in preterm infants: a protocol for a systematic review and network meta-analysis. 38
31427322 2019
2
Positional treatment without mechanical ventilation in a very preterm infant with unilateral pulmonary interstitial emphysema: case report and review of the literature. 38
31370828 2019
3
Acquired neonatal bronchial stenosis after selective intubation: Successful managed with balloon dilatation. 38
31110714 2019
4
Differential Lung Ventilation Using a Bronchial Blocker in a Pediatric Patient on Extracorporeal Membrane Oxygenation: A Case Report. 38
31162224 2019
5
CT features of pulmonary interstitial emphysema. 38
31053558 2019
6
Pulmonary interstitial emphysema is a risk factor for poor prognosis and a cause of air leaks. 38
31043328 2019
7
Predictors of outcome of prematurely born infants with pulmonary interstitial emphysema. 38
29754462 2019
8
Images in Anesthesiology: Persistent Pulmonary Interstitial Emphysema. 38
30234591 2018
9
Pulmonary cysts in smoking-related interstitial fibrosis: a form of pseudocyst secondary to pulmonary interstitial emphysema. 38
30269779 2018
10
Lobectomy with ECMO Support in an Infant Who Developed Pulmonary Interstitial Emphysema Following Repair of Hypoplastic Aortic Arch. 38
30517264 2018
11
Behavioral Characteristics and Medicolegal Identification of Infanticide. 38
30896108 2018
12
Pneumoperitoneum in a neonate weighing less than 500 g. What do we really know about it? 38
29769190 2018
13
Persistent Pulmonary Interstitial Emphysema. 38
29738327 2018
14
Early Pulmonary Interstitial Emphysema in Preterm Neonates-Respiratory Management and Case Report in Nonventilated Very Low Birth Weight Twins. 38
29765788 2018
15
Two Cases of Chloromethylisothiazolinone and Methylisothiazolinone-associated Toxic Lung Injury. 38
29651817 2018
16
Bilateral pulmonary interstitial emphysema in a preterm infant on continuous positive airway pressure: clinical and radiological correlation. 38
29743753 2018
17
Pulmonary interstitial emphysema in fatal asthma: case report and histopathological review. 38
29554886 2018
18
Pulmonary Barotrauma Including Huge Pulmonary Interstitial Emphysema in an Adult with Status Asthmaticus: Diagnostic and Therapeutic Challenges. 38
30756032 2018
19
Oxygen needs during resuscitation and surfactant to achieve stabilisation were independent risks factors for pulmonary interstitial emphysema in preterm infants. 38
28851119 2018
20
Application of Selective Bronchial Intubation versus Neurally Adjusted Ventilatory Assist in the Management of Unilateral Pulmonary Interstitial Emphysema: An Illustrative Case and the Literature Review. 38
28515969 2017
21
Pneumoperitoneum without Intestinal Perforation in a Neonate: Case Report and Literature Review. 38
28567320 2017
22
Neonatal Pneumopericardium in a Nonventilated Term Infant: A Case Report and Review of the Literature. 38
29430316 2017
23
Humidifier disinfectant-associated lung injury in adults: Prognostic factors in predicting short-term outcome. 38
27147415 2017
24
Presence of subpleural pulmonary interstitial emphysema as an indication of single or multiple alveolar ruptures on CT in patients with spontaneous pneumomediastinum. 38
26868169 2016
25
Steroid-induced resolution of refractory pulmonary interstitial emphysema. 38
26952563 2016
26
Bronchodilators for the prevention and treatment of chronic lung disease in preterm infants. 38
27960245 2016
27
Diffuse persistent pulmonary interstitial emphysema secondary to mechanical ventilation in bronchiolitis. 38
27809884 2016
28
A Case of Pulmonary Interstitial Emphysema Treated by Percutaneous Catheter Insertion in Extremely Low Birth Weight Infant. 38
27593885 2016
29
[Blunt chest trauma with pneumomediastinum and pneumoperitoneum secondary to Macklin effect. Case report]. 38
26769517 2016
30
Synchronized mechanical ventilation for respiratory support in newborn infants. 38
27581993 2016
31
Pulmonary interstitial emphysema due to respiratory syncytial virus infection. 38
27435178 2016
32
Synchronized mechanical ventilation for respiratory support in newborn infants. 38
27539719 2016
33
Nonsurgical management of an enlarging pneumatocele by fibrin sealant injection via pigtail catheter. 38
26340670 2016
34
Nasal Mask Versus Nasal Prongs for Delivering Nasal Continuous Positive Airway Pressure in Preterm Infants with Respiratory Distress: A Randomized Controlled Trial. 38
26713987 2015
35
Pulmonary interstitial emphysema following spirometry in CPFE syndrome. 38
26071368 2015
36
Pneumomediastinum, pneumorrhachis and subcutaneous emphysema associated with viral infections: Report of three cases. 38
26508192 2015
37
IMAGING DIAGNOSIS-SPONTANEOUS PNEUMOMEDIASTINUM SECONDARY TO PRIMARY PULMONARY PATHOLOGY IN A DALMATIAN DOG. 38
25388364 2015
38
Rare congenital pulmonary malformation with diagnostic challenging: congenital pulmonary lymphangiectasia, report of four autopsy cases and review of literature. 38
25142108 2015
39
Volume guarantee pressure support ventilation in extremely preterm infants and neurodevelopmental outcome at 18 months. 38
25569681 2015
40
Spontaneous Chest Wall Interstitial Emphysema Secondary to Chronic Empyema Thoracis. 38
26266188 2015
41
Lung ultrasound: a useful tool for the follow-up of neonatal localized interstitial emphysema. 38
25799192 2015
42
Elective high frequency oscillatory ventilation versus conventional ventilation for acute pulmonary dysfunction in preterm infants. 38
25785789 2015
43
Perinatal conditions related to growth restriction and inflammation are associated with an increased risk of bronchopulmonary dysplasia. 38
25469645 2015
44
A comparative study of honeycombing on high resolution computed tomography with histologic lung remodeling in explants with usual interstitial pneumonia. 38
25433993 2015
45
Pneumomediastinum and pulmonary interstitial emphysema after tracheal taser injury. 38
24057765 2015
46
Risk Indicators for Air Leaks in Preterm Infants Exposed to Restrictive Use of Endotracheal Intubation. 38
25825229 2015
47
Surfactant for meconium aspiration syndrome in term and late preterm infants. 38
25504256 2014
48
Pulmonary interstitial emphysema after resolution of relapsing pneumothorax and discontinuation of mechanical ventilation. An atypical case in a preterm infant. 38
24245490 2014
49
Surgical salvage of acquired lung lesions in extremely premature infants. 38
24525614 2014
50
Persistent pulmonary interstitial emphysema in a case of Langerhans cell histiocytosis. 38
25024518 2014

Variations for Interstitial Emphysema

Expression for Interstitial Emphysema

Search GEO for disease gene expression data for Interstitial Emphysema.

Pathways for Interstitial Emphysema

Pathways related to Interstitial Emphysema according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.7 LY96 FLT4 FLT1
2 10.87 PROX1 PECAM1 FLT4 FLT1
3 10.59 FLT4 FLT1

GO Terms for Interstitial Emphysema

Cellular components related to Interstitial Emphysema according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.5 SLC22A4 PECAM1 LY96 FLT4 FLT1 CD34
2 extracellular region GO:0005576 9.1 LY96 LY86 FLT4 FLT1 ELANE CD34

Biological processes related to Interstitial Emphysema according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 angiogenesis GO:0001525 9.67 PECAM1 FLT4 FLT1
2 leukocyte migration GO:0050900 9.63 PECAM1 ELANE CD34
3 response to lipopolysaccharide GO:0032496 9.58 LY96 ELANE ABCC8
4 positive regulation of tumor necrosis factor production GO:0032760 9.52 LY96 ABCC8
5 positive regulation of endothelial cell migration GO:0010595 9.51 PROX1 FLT4
6 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.48 FLT4 FLT1
7 blood vessel morphogenesis GO:0048514 9.43 FLT4 FLT1
8 vascular endothelial growth factor signaling pathway GO:0038084 9.37 FLT4 FLT1
9 response to pH GO:0009268 9.32 TTPA ABCC8
10 lymphangiogenesis GO:0001946 9.26 PROX1 FLT4
11 lymph vessel development GO:0001945 9.16 PROX1 FLT4
12 positive regulation of lipopolysaccharide-mediated signaling pathway GO:0031666 8.96 LY96 LY86
13 glomerular endothelium development GO:0072011 8.62 PECAM1 CD34

Molecular functions related to Interstitial Emphysema according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.16 FLT4 FLT1
2 growth factor binding GO:0019838 8.96 FLT4 FLT1
3 vascular endothelial growth factor-activated receptor activity GO:0005021 8.62 FLT4 FLT1

Sources for Interstitial Emphysema

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
Content
Loading form....