MCID: INT065
MIFTS: 29

Interstitial Keratitis

Categories: Eye diseases

Aliases & Classifications for Interstitial Keratitis

MalaCards integrated aliases for Interstitial Keratitis:

Name: Interstitial Keratitis 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:9857
ICD10 33 H16.30
ICD9CM 35 370.50
SNOMED-CT 68 1763009 193784002
UMLS 73 C0155088

Summaries for Interstitial Keratitis

MalaCards based summary : Interstitial Keratitis is related to diffuse interstitial keratitis and idiopathic linear interstitial keratitis. An important gene associated with Interstitial Keratitis is DCN (Decorin), and among its related pathways/superpathways are Degradation of the extracellular matrix and ECM-receptor interaction. Affiliated tissues include eye, t cells and testes, and related phenotype is Increased gamma-H2AX phosphorylation.

Wikipedia : 76 Interstitial keratitis (IK) is corneal scarring due to chronic inflammation of the corneal stroma.... more...

Related Diseases for Interstitial Keratitis

Diseases related to Interstitial Keratitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 46)
# Related Disease Score Top Affiliating Genes
1 diffuse interstitial keratitis 12.2
2 idiopathic linear interstitial keratitis 12.1
3 cogan syndrome 11.0
4 late congenital syphilis 11.0
5 syphilis 10.2
6 eosinophilic granuloma 10.0 CD36 DCN
7 congenital syphilis 10.0
8 odontogenic myxoma 10.0 CD36 DCN
9 uveitis 9.9
10 hidradenitis suppurativa 9.9
11 hidradenitis 9.9
12 arthritis 9.8
13 aortitis 9.8
14 herpes simplex 9.8
15 periostitis 9.8
16 gingival overgrowth 9.8 CD36 DCN
17 keloids 9.8 CD36 TNC
18 rheumatoid arthritis 9.7
19 gapo syndrome 9.7
20 aging 9.7
21 malaria 9.7
22 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 9.7
23 cataract 9.7
24 keratoconus 9.7
25 sensorineural hearing loss 9.7
26 chlamydia 9.7
27 choroiditis 9.7
28 lyme disease 9.7
29 posterior uveitis 9.7
30 skin sarcoidosis 9.7
31 hypothyroidism 9.7
32 cervicitis 9.7
33 vaccinia 9.7
34 reactive arthritis 9.7
35 thyroiditis 9.7
36 vasculitis 9.7
37 smallpox 9.7
38 chorioretinitis 9.7
39 leishmaniasis 9.7
40 amyloidosis 9.7
41 mucocutaneous leishmaniasis 9.7
42 ophthalmia neonatorum 9.7
43 type i 9.7
44 spasticity 9.7
45 brittle bone disorder 9.6 CD36 DCN
46 deep keratitis 8.8 PTPRJ TNC UTP6

Graphical network of the top 20 diseases related to Interstitial Keratitis:



Diseases related to Interstitial Keratitis

Symptoms & Phenotypes for Interstitial Keratitis

GenomeRNAi Phenotypes related to Interstitial Keratitis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased gamma-H2AX phosphorylation GR00053-A 8.92 COL9A1 DCN PTPRJ UTP6

Drugs & Therapeutics for Interstitial Keratitis

Search Clinical Trials , NIH Clinical Center for Interstitial Keratitis

Genetic Tests for Interstitial Keratitis

Anatomical Context for Interstitial Keratitis

MalaCards organs/tissues related to Interstitial Keratitis:

41
Eye, T Cells, Testes, Bone, Bone Marrow, Thyroid

Publications for Interstitial Keratitis

Articles related to Interstitial Keratitis:

(show top 50) (show all 150)
# Title Authors Year
1
Characteristics of Linear Interstitial Keratitis by In Vivo Confocal Microscopy and Anterior Segment Optical Coherence Tomography. ( 29543661 )
2018
2
Keratoconus-like tomographic changes in a case of recurrent interstitial keratitis. ( 29516199 )
2018
3
Interstitial Keratitis in Cogan's Syndrome. ( 29490187 )
2018
4
Unilateral Posterior Interstitial Keratitis as a Clinical Presentation of Herpes Simplex Virus Disease. ( 29256984 )
2018
5
Scheimpflug-based Optical Densitometry for Assessment of Corneal Opacity: An Objective Method to Monitor Interstitial Keratitis. ( 29719653 )
2018
6
Bilateral interstitial keratitis with anterior stromal infiltrates associated with reactive arthritis. ( 28687682 )
2017
7
Syphilitic Interstitial Keratitis in a Patient Diagnosed With SjAPgren's Syndrome. ( 29280828 )
2017
8
Hemorrhagic Descemet Membrane Detachment Following Syphilitic Interstitial Keratitis. ( 27227396 )
2016
9
Therapeutic Effect of 0.1% Topical Tacrolimus for Childhood Interstitial Keratitis Refractory to Cyclosporine. ( 26960587 )
2016
10
Descemet's scroll in syphilitic interstitial keratitis: a case report with anterior segment evaluation and a literature review. ( 26451126 )
2015
11
Interstitial Keratitis, Vertigo, and Vasculitis: Typical Cogan's Syndrome. ( 24715922 )
2014
12
Bilateral Interstitial Keratitis and Granulomatous Uveitis of Tubercular Origin. ( 23538732 )
2013
13
Interstitial keratitis and sensorineural hearing loss as a manifestation of rheumatoid arthritis: clinical lessons from a rare complication. ( 23242087 )
2012
14
Linear interstitial keratitis: a distinct clinical entity revisited. ( 22406946 )
2012
15
Interstitial keratitis secondary to severe hidradenitis suppurativa responding to adalimumab. ( 22146546 )
2012
16
Interstitial keratitis secondary to severe hidradenitis suppurativa: a case report and literature review. ( 20628295 )
2010
17
Exacerbation of zoster interstitial keratitis after zoster vaccination in an adult. ( 20697015 )
2010
18
GAPO syndrome: a case associated with bilateral interstitial keratitis and hypothyroidism. ( 20032780 )
2010
19
Interstitial keratitis following varicella vaccination. ( 19204247 )
2009
20
Effective treatment with topical cyclosporine of a child with steroid-dependent interstitial keratitis. ( 18850565 )
2008
21
Immunohistochemistry and electron microscopy of retrocorneal scrolls in syphilitic interstitial keratitis. ( 17963106 )
2007
22
Peripheral interstitial keratitis: a novel manifestation of ocular mastocytosis. ( 16633043 )
2006
23
Syphilitic interstitial keratitis: treatment with immunosuppressive drug combination therapy. ( 15220743 )
2004
24
Immune recovery disease: a case of interstitial keratitis and tonic pupil following bone marrow transplantation. ( 15548824 )
2004
25
Results of penetrating keratoplasty in syphilitic interstitial keratitis. ( 14750229 )
2003
26
Images in clinical medicine. Interstitial keratitis as the initial expression of syphilitic reactivation. ( 12050340 )
2002
27
Rapid improvement of chronic interstitial keratitis with acitretin. ( 12446388 )
2002
28
Interstitial keratitis and deafness in a patient with cutaneous sarcoidosis. ( 11702638 )
2001
29
A description of human T-lymphotropic virus type I-related chronic interstitial keratitis in 20 patients. ( 11239861 )
2001
30
Extracellular matrix components in a case of retrocorneal membrane associated with syphilitic interstitial keratitis. ( 11188990 )
2001
31
Gold induced interstitial keratitis. ( 11702733 )
2001
32
Tegument-specific, virus-reactive CD4 T cells localize to the cornea in herpes simplex virus interstitial keratitis in humans. ( 11069987 )
2000
33
Interstitial keratitis in a five-year-old. ( 10093958 )
1999
34
Lyme disease associated with unilateral interstitial keratitis. ( 9894947 )
1999
35
Etiology of immune stromal (interstitial) keratitis. ( 9603383 )
1998
36
Interstitial keratitis. ( 10081734 )
1998
37
Syphilitic interstitial keratitis with bilateral funnel-shaped iridocorneal adhesions. A case report. ( 8744842 )
1996
38
Characterization of native pathogenic antigens of Onchocerca volvulus: identification of high molecular mass protein antigens eliciting interstitial keratitis in a guinea pig model. ( 7789415 )
1995
39
Interstitial keratitis as presenting ophthalmic sign of sarcoidosis in a child. ( 7636703 )
1995
40
Diagnosis of congenital syphilis in adults presenting with interstitial keratitis. ( 8069759 )
1994
41
Unilateral iridoschisis associated with syphilitic interstitial keratitis and glaucoma. ( 8297067 )
1993
42
Secondary localized amyloidosis in interstitial keratitis. Clinicopathologic findings. ( 1594229 )
1992
43
Interstitial keratitis and iridoschisis in congenital syphilis. ( 1401161 )
1992
44
Case report: clinical and radiological features of Cogan's syndrome--non-syphilitic interstitial keratitis, audiovestibular symptoms and systemic manifestations. ( 1606804 )
1992
45
Late corneal opacities in the syndrome of interstitial keratitis and vestibulo-auditory symptoms. ( 2554651 )
1989
46
Iridoschisis associated with syphilitic interstitial keratitis. ( 2912127 )
1989
47
Syphilitic interstitial keratitis masquerading as staphylococcal marginal keratitis. ( 2929714 )
1989
48
Syphilitic interstitial keratitis. ( 2810630 )
1989
49
Experimental interstitial keratitis induced by Onchocerca volvulus antigens. ( 2460073 )
1988
50
Interstitial keratitis in untreated latent (late) syphilis. ( 3801205 )
1986

Variations for Interstitial Keratitis

Expression for Interstitial Keratitis

Search GEO for disease gene expression data for Interstitial Keratitis.

Pathways for Interstitial Keratitis

Pathways related to Interstitial Keratitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.99 COL9A1 DCN TNC
2
Show member pathways
11.31 CD36 COL9A1 TNC
3 10.56 COL9A1 DCN TNC

GO Terms for Interstitial Keratitis

Cellular components related to Interstitial Keratitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 collagen trimer GO:0005581 8.96 CD36 COL9A1
2 specific granule membrane GO:0035579 8.62 CD36 PTPRJ

Biological processes related to Interstitial Keratitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 animal organ morphogenesis GO:0009887 9.26 COL9A1 DCN
2 wound healing GO:0042060 9.16 DCN TNC
3 response to mechanical stimulus GO:0009612 8.96 DCN TNC
4 extracellular matrix organization GO:0030198 8.8 COL9A1 DCN TNC

Sources for Interstitial Keratitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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