Aliases & Classifications for Interstitial Keratitis

MalaCards integrated aliases for Interstitial Keratitis:

Name: Interstitial Keratitis 12 15 74

External Ids:

Disease Ontology 12 DOID:9857
ICD9CM 36 370.50
SNOMED-CT 69 1763009
ICD10 34 H16.30
UMLS 74 C0155088

Summaries for Interstitial Keratitis

Disease Ontology : 12 A connective tissue disease characterized by corneal scarring that develops from non-suppurative inflammation located in the corneal stroma, has symptom visual acuity loss, has symptom pain, and has symptom lacrimation.

MalaCards based summary : Interstitial Keratitis is related to diffuse interstitial keratitis and idiopathic linear interstitial keratitis, and has symptoms including pain, visual acuity loss and lacrimation. An important gene associated with Interstitial Keratitis is DCN (Decorin), and among its related pathways/superpathways are Degradation of the extracellular matrix and Microglia Activation During Neuroinflammation: Overview. Affiliated tissues include bone, eye and testes, and related phenotype is Increased gamma-H2AX phosphorylation.

Wikipedia : 77 Interstitial keratitis (IK) is corneal scarring due to chronic inflammation of the corneal stroma.... more...

Related Diseases for Interstitial Keratitis

Graphical network of the top 20 diseases related to Interstitial Keratitis:



Diseases related to Interstitial Keratitis

Symptoms & Phenotypes for Interstitial Keratitis

Symptoms:

12
  • pain
  • visual acuity loss
  • lacrimation

GenomeRNAi Phenotypes related to Interstitial Keratitis according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased gamma-H2AX phosphorylation GR00053-A 8.92 COL9A1 DCN PTPRJ UTP6

Drugs & Therapeutics for Interstitial Keratitis

Search Clinical Trials , NIH Clinical Center for Interstitial Keratitis

Genetic Tests for Interstitial Keratitis

Anatomical Context for Interstitial Keratitis

MalaCards organs/tissues related to Interstitial Keratitis:

42
Bone, Eye, Testes, Thyroid, Bone Marrow, T Cells, Skin

The Foundational Model of Anatomy Ontology organs/tissues related to Interstitial Keratitis:

20
The Corneal Stroma

Publications for Interstitial Keratitis

Articles related to Interstitial Keratitis:

(show top 50) (show all 160)
# Title Authors Year
1
Interstitial Keratitis with Corneal Perforation as the Presenting Sign of Systemic Tuberculosis. ( 30806115 )
2019
2
Interstitial keratitis diagnosis and treatment. ( 31103357 )
2019
3
Unilateral Posterior Interstitial Keratitis as a Clinical Presentation of Herpes Simplex Virus Disease. ( 29256984 )
2018
4
Syphilitic Interstitial Keratitis in a Patient Diagnosed With Sjögren's Syndrome. ( 29280828 )
2018
5
Interstitial Keratitis in Cogan's Syndrome. ( 29490187 )
2018
6
Keratoconus-like tomographic changes in a case of recurrent interstitial keratitis. ( 29516199 )
2018
7
Characteristics of Linear Interstitial Keratitis by In Vivo Confocal Microscopy and Anterior Segment Optical Coherence Tomography. ( 29543661 )
2018
8
Scheimpflug-based Optical Densitometry for Assessment of Corneal Opacity: An Objective Method to Monitor Interstitial Keratitis. ( 29719653 )
2018
9
Bilateral interstitial keratitis with anterior stromal infiltrates associated with reactive arthritis. ( 28687682 )
2017
10
Therapeutic Effect of 0.1% Topical Tacrolimus for Childhood Interstitial Keratitis Refractory to Cyclosporine. ( 26960587 )
2016
11
Hemorrhagic Descemet Membrane Detachment Following Syphilitic Interstitial Keratitis. ( 27227396 )
2016
12
Descemet's scroll in syphilitic interstitial keratitis: a case report with anterior segment evaluation and a literature review. ( 26451126 )
2015
13
Bilateral interstitial keratitis and granulomatous uveitis of tubercular origin. ( 23538732 )
2014
14
Interstitial Keratitis, Vertigo, and Vasculitis: Typical Cogan's Syndrome. ( 24715922 )
2014
15
Interstitial keratitis secondary to severe hidradenitis suppurativa responding to adalimumab. ( 22146546 )
2012
16
Linear interstitial keratitis: a distinct clinical entity revisited. ( 22406946 )
2012
17
Interstitial keratitis and sensorineural hearing loss as a manifestation of rheumatoid arthritis: clinical lessons from a rare complication. ( 23242087 )
2012
18
GAPO syndrome: a case associated with bilateral interstitial keratitis and hypothyroidism. ( 20032780 )
2010
19
Interstitial keratitis secondary to severe hidradenitis suppurativa: a case report and literature review. ( 20628295 )
2010
20
Exacerbation of zoster interstitial keratitis after zoster vaccination in an adult. ( 20697015 )
2010
21
Interstitial keratitis following varicella vaccination. ( 19204247 )
2009
22
Effective treatment with topical cyclosporine of a child with steroid-dependent interstitial keratitis. ( 18850565 )
2008
23
Immunohistochemistry and electron microscopy of retrocorneal scrolls in syphilitic interstitial keratitis. ( 17963106 )
2007
24
Peripheral interstitial keratitis: a novel manifestation of ocular mastocytosis. ( 16633043 )
2006
25
Syphilitic interstitial keratitis: treatment with immunosuppressive drug combination therapy. ( 15220743 )
2004
26
Immune recovery disease: a case of interstitial keratitis and tonic pupil following bone marrow transplantation. ( 15548824 )
2004
27
Results of penetrating keratoplasty in syphilitic interstitial keratitis. ( 14750229 )
2003
28
Images in clinical medicine. Interstitial keratitis as the initial expression of syphilitic reactivation. ( 12050340 )
2002
29
Rapid improvement of chronic interstitial keratitis with acitretin. ( 12446388 )
2002
30
Extracellular matrix components in a case of retrocorneal membrane associated with syphilitic interstitial keratitis. ( 11188990 )
2001
31
A description of human T-lymphotropic virus type I-related chronic interstitial keratitis in 20 patients. ( 11239861 )
2001
32
Interstitial keratitis and deafness in a patient with cutaneous sarcoidosis. ( 11702638 )
2001
33
Gold induced interstitial keratitis. ( 11702733 )
2001
34
Tegument-specific, virus-reactive CD4 T cells localize to the cornea in herpes simplex virus interstitial keratitis in humans. ( 11069987 )
2000
35
Lyme disease associated with unilateral interstitial keratitis. ( 9894947 )
1999
36
Interstitial keratitis in a five-year-old. ( 10093958 )
1999
37
Etiology of immune stromal (interstitial) keratitis. ( 9603383 )
1998
38
Interstitial keratitis. ( 10081734 )
1998
39
Syphilitic interstitial keratitis with bilateral funnel-shaped iridocorneal adhesions. A case report. ( 8744842 )
1996
40
In vivo molecular analysis of cytokines in a murine model of ocular onchocerciasis. I. Up-regulation of IL-4 and IL-5 mRNAs and not IL-2 and IFN gamma mRNAs in the cornea due to experimental interstitial keratitis. ( 9030983 )
1996
41
Interstitial keratitis as presenting ophthalmic sign of sarcoidosis in a child. ( 7636703 )
1995
42
Characterization of native pathogenic antigens of Onchocerca volvulus: identification of high molecular mass protein antigens eliciting interstitial keratitis in a guinea pig model. ( 7789415 )
1995
43
Diagnosis of congenital syphilis in adults presenting with interstitial keratitis. ( 8069759 )
1994
44
Unilateral iridoschisis associated with syphilitic interstitial keratitis and glaucoma. ( 8297067 )
1993
45
Interstitial keratitis and iridoschisis in congenital syphilis. ( 1401161 )
1992
46
Secondary localized amyloidosis in interstitial keratitis. Clinicopathologic findings. ( 1594229 )
1992
47
Case report: clinical and radiological features of Cogan's syndrome--non-syphilitic interstitial keratitis, audiovestibular symptoms and systemic manifestations. ( 1606804 )
1992
48
Syphilitic interstitial keratitis. ( 2810630 )
1989
49
Iridoschisis associated with syphilitic interstitial keratitis. ( 2912127 )
1989
50
Syphilitic interstitial keratitis masquerading as staphylococcal marginal keratitis. ( 2929714 )
1989

Variations for Interstitial Keratitis

Expression for Interstitial Keratitis

Search GEO for disease gene expression data for Interstitial Keratitis.

Pathways for Interstitial Keratitis

Pathways related to Interstitial Keratitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.99 COL9A1 DCN TNC
2
Show member pathways
11.36 CD36 TNC
3
Show member pathways
11.32 CD36 COL9A1 TNC
4 10.56 COL9A1 DCN TNC

GO Terms for Interstitial Keratitis

Cellular components related to Interstitial Keratitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.46 CD36 COL9A1 DCN TNC
2 specific granule membrane GO:0035579 8.96 CD36 PTPRJ
3 extracellular matrix GO:0031012 8.8 COL9A1 DCN TNC

Biological processes related to Interstitial Keratitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of MAPK cascade GO:0043410 9.4 CD36 PTPRJ
2 animal organ morphogenesis GO:0009887 9.37 COL9A1 DCN
3 wound healing GO:0042060 9.32 DCN TNC
4 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.26 CD36 PTPRJ
5 response to mechanical stimulus GO:0009612 9.16 DCN TNC
6 positive regulation of tumor necrosis factor production GO:0032760 8.96 CD36 PTPRJ
7 extracellular matrix organization GO:0030198 8.8 COL9A1 DCN TNC

Molecular functions related to Interstitial Keratitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix structural constituent GO:0005201 8.62 COL9A1 TNC

Sources for Interstitial Keratitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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