Aliases & Classifications for Interstitial Keratitis

MalaCards integrated aliases for Interstitial Keratitis:

Name: Interstitial Keratitis 12 15 70

External Ids:

Disease Ontology 12 DOID:9857
ICD9CM 34 370.50
SNOMED-CT 67 1763009
ICD10 32 H16.30
UMLS 70 C0155088

Summaries for Interstitial Keratitis

Disease Ontology : 12 A connective tissue disease characterized by corneal scarring that develops from non-suppurative inflammation located in the corneal stroma, has symptom visual acuity loss, has symptom pain, and has symptom lacrimation.

MalaCards based summary : Interstitial Keratitis is related to cogan syndrome and corneal edema, and has symptoms including pain, visual acuity loss and lacrimation. An important gene associated with Interstitial Keratitis is DCN (Decorin), and among its related pathways/superpathways are Degradation of the extracellular matrix and ECM-receptor interaction. Affiliated tissues include corneal stroma, eye and endothelial.

Wikipedia : 73 Interstitial keratitis (IK) is corneal scarring due to chronic inflammation of the corneal stroma.... more...

Related Diseases for Interstitial Keratitis

Diseases related to Interstitial Keratitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 138)
# Related Disease Score Top Affiliating Genes
1 cogan syndrome 31.6 SNORA59A PTPRJ CRP
2 corneal edema 30.0 TGFBI COL8A2
3 corneal disease 29.5 TGFBI DCN CRYAA COL8A2
4 bullous keratopathy 29.4 TNC DCN
5 diffuse interstitial keratitis 11.1
6 idiopathic linear interstitial keratitis 11.1
7 late congenital syphilis 11.1
8 keratitis, hereditary 11.0
9 syphilis 10.5
10 congenital syphilis 10.3
11 branchiootic syndrome 1 10.3
12 odontogenic myxoma 10.3 DCN CD36
13 uveitis 10.3
14 yemenite deaf-blind hypopigmentation syndrome 10.2
15 cornea plana 10.2 DCN CRYAA
16 osteochondrosis 10.2 COL9A1 CD36
17 achondrogenesis, type ii 10.2 COL9A1 CD36
18 stromal corneal dystrophy 10.2 TGFBI DCN
19 orbital cellulitis 10.1 CRYAA CRP
20 sarcoidosis 1 10.1
21 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.1
22 keratopathy 10.1
23 iridocyclitis 10.1
24 acute orbital inflammation 10.1 CRYAA CRP
25 branch retinal artery occlusion 10.1 CRYAA CRP
26 macular dystrophy, corneal 10.1 TGFBI DCN
27 retinal artery occlusion 10.1 CRYAA CRP
28 marfan syndrome 10.1 DCN COL9A1 CD36
29 central retinal artery occlusion 10.1 CRYAA CRP
30 tendinitis 10.1 DCN CRP
31 juvenile arthritis 10.1 CRP CD36
32 osteochondritis dissecans 10.1 COL9A1 CD36
33 orbital disease 10.1 CRYAA CRP
34 phimosis 10.1 CRYAA CRP
35 mediastinitis 10.1 SNORA59A CRP
36 blood group, globoside system 10.1 CRYAA CRP
37 corneal dystrophy, avellino type 10.1 TGFBI CRYAA
38 volvulus of midgut 10.1
39 intraocular pressure quantitative trait locus 10.1
40 disease by infectious agent 10.1
41 sensorineural hearing loss 10.1
42 choroiditis 10.1
43 sclerosing keratitis 10.1
44 hidradenitis suppurativa 10.1
45 hidradenitis 10.1
46 aortitis 10.1
47 conjunctivitis 10.1
48 herpes simplex 10.1
49 chorioretinitis 10.1
50 periostitis 10.1

Graphical network of the top 20 diseases related to Interstitial Keratitis:



Diseases related to Interstitial Keratitis

Symptoms & Phenotypes for Interstitial Keratitis

Symptoms:

12
  • pain
  • visual acuity loss
  • lacrimation

Drugs & Therapeutics for Interstitial Keratitis

Search Clinical Trials , NIH Clinical Center for Interstitial Keratitis

Genetic Tests for Interstitial Keratitis

Anatomical Context for Interstitial Keratitis

The Foundational Model of Anatomy Ontology organs/tissues related to Interstitial Keratitis:

19
Corneal Stroma

MalaCards organs/tissues related to Interstitial Keratitis:

40
Eye, Endothelial, Retina, Bone Marrow, Placenta, T Cells, Neutrophil

Publications for Interstitial Keratitis

Articles related to Interstitial Keratitis:

(show top 50) (show all 434)
# Title Authors PMID Year
1
A "shining" example of interstitial keratitis. 61
33437893 2021
2
Lyme disease presenting as persistent severe photophobia. 61
33348040 2021
3
Interstitial Keratitis with Lipid Keratopathy Mimicking Corneal Opacity Induced by Brimonidine Tartrate Eye Drops. 61
33285590 2020
4
[Syncope, pain in the large joints, and painful swelling of the right eye in a 51-year-old patient : Pitfalls in the diagnosis and treatment of a rare disease]. 61
33001239 2020
5
Bilateral interstitial keratitis as the presenting manifestation of systemic lupus erythematosus in a child. 61
33245862 2020
6
[Interstitial keratitis in a symptom triad]. 61
33064190 2020
7
Ocular Involvement Preceded the Onset of Cutaneous Lesions in Hydroa Vacciniforme-Like Lymphoproliferative Disorder: A Case Report. 61
33021425 2020
8
Atypical Cogan Syndrome Featuring Orbital Myositis and Dacryoadenitis. 61
32991499 2020
9
Delayed-onset Bilateral Peripheral Posterior Interstitial Keratitis Associated with Epstein-Barr Virus-Induced Infectious Mononucleosis. 61
32946296 2020
10
Concurrent primary Sjögren's syndrome and isolated ocular sarcoidosis presenting with bilateral corneal scarring and dry eye. 61
32613141 2020
11
Syndrome de Cogan. 61
32773166 2020
12
Familial HLA-B*52 Vasculitis: Maternal, Atypical Cogan's Syndrome with Takayasu Arteritis-mimicking Aortitis and Filial Takayasu Arteritis. 61
32321889 2020
13
Cogan syndrome: Descriptive analysis and clinical experience of 7 cases diagnosed and treated in two third level hospitals. 61
32571733 2020
14
Bilateral interstitial keratitis, erythema nodosum and atrial fibrillation as presenting signs of polyarteritis nodosa. 61
32140612 2020
15
Interstitial Keratitis with Corneal Perforation as the Presenting Sign of Systemic Tuberculosis. 61
30806115 2020
16
[Bilateral Linear Interstitial Keratitis in a Patient with Unilateral Recurrent Herpetic Keratitis]. 61
32219778 2020
17
[Interstitial keratitis diagnosis and treatment (French translation of the article)]. 61
31870670 2020
18
HTLV-1 in Ophthalmology. 61
32218778 2020
19
Clinical Features of Ocular Syphilis: a Retrospective Clinical Study in an Italian Referral Centre. 61
32036734 2020
20
Cogan syndrome: An autoimmune eye and ear disease with systemic manifestations. 61
33380629 2019
21
Late-onset Cogan's syndrome associated with large-vessel vasculitis. 61
28583785 2019
22
Hepatic vasculitis mimicking multiple liver abscesses in Cogan's Syndrome. 61
31308353 2019
23
Interstitial keratitis diagnosis and treatment. 61
31103357 2019
24
Syphilitic Interstitial Keratitis in a Patient Diagnosed With Sjögren's Syndrome. 61
29280828 2018
25
Characteristics of Linear Interstitial Keratitis by In Vivo Confocal Microscopy and Anterior Segment Optical Coherence Tomography. 61
29543661 2018
26
Scheimpflug-based Optical Densitometry for Assessment of Corneal Opacity: An Objective Method to Monitor Interstitial Keratitis. 61
29719653 2018
27
Unilateral Posterior Interstitial Keratitis as a Clinical Presentation of Herpes Simplex Virus Disease. 61
29256984 2018
28
Keratoconus-like tomographic changes in a case of recurrent interstitial keratitis. 61
29516199 2018
29
Interstitial Keratitis in Cogan's Syndrome. 61
29490187 2018
30
Anterior segment and external ocular disorders associated with HIV infections in the era of HAART in Chiang Mai University Hospital, a prospective descriptive cross sectional study. 61
29466424 2018
31
Syphilis. 61
30578519 2018
32
Optimal management of Cogan's syndrome: a multidisciplinary approach. 61
29317827 2018
33
Cogan syndrome: Characteristics, outcome and treatment in a French nationwide retrospective study and literature review. 61
29037902 2017
34
Bilateral interstitial keratitis with anterior stromal infiltrates associated with reactive arthritis. 61
28687682 2017
35
Congenital heart block and immune mediated sensorineural hearing loss: possible cross reactivity of immune response. 61
27913750 2017
36
Human T Cell Leukemia Virus Type 1 and Eye Diseases. 61
28263674 2017
37
Ocular Complications in Survivors of the Ebola Outbreak in Guinea. 61
27998698 2017
38
Autoimmune Ear Disease: Clinical and Diagnostic Relevance in Cogan's Sydrome. 61
28458810 2017
39
Histopathology of the Human Inner Ear in the Cogan Syndrome with Cochlear Implantation. 61
28848089 2017
40
[Ocular syphilis: 9 cases]. 61
27765446 2016
41
Non-human Immunodeficiency Virus-related Ocular Syphilis in a Korean Population: Clinical Manifestations and Treatment Outcomes. 61
27729756 2016
42
Epidemiological Profile of Patients Undergoing Urgent Corneal Transplant in a Referral Center in Northeastern Brazil. 61
27742299 2016
43
Hemorrhagic Descemet Membrane Detachment Following Syphilitic Interstitial Keratitis. 61
27227396 2016
44
Therapeutic Effect of 0.1% Topical Tacrolimus for Childhood Interstitial Keratitis Refractory to Cyclosporine. 61
26960587 2016
45
Histopathology of the Inner Ear in a Case With Recent Onset of Cogan's Syndrome: Evidence for Vasculitis. 61
26195577 2016
46
Herpes Simplex Virus Disease of the Anterior Segment in Children. 61
26266435 2015
47
Paraproteinemic Keratopathy: The Expanding Diversity of Clinical and Pathologic Manifestations. 61
26118999 2015
48
Do Unilateral Herpetic Stromal Keratitis and Neurotrophic Ulcers Cause Bilateral Dry Eye? 61
25933398 2015
49
[The Chameleon of Herpetic Keratitis - Diagnosis and Therapy]. 61
26084963 2015
50
Pathological Response of Northern Bobwhites to Oxyspirura petrowi Infections. 61
25723500 2015

Variations for Interstitial Keratitis

Expression for Interstitial Keratitis

Search GEO for disease gene expression data for Interstitial Keratitis.

Pathways for Interstitial Keratitis

Pathways related to Interstitial Keratitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.91 TNC DCN COL9A1 COL8A2
2
Show member pathways
11.52 TNC COL9A1 CD36
3 10.56 TNC DCN COL9A1

GO Terms for Interstitial Keratitis

Cellular components related to Interstitial Keratitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.8 TNC TGFBI DCN CRP COL9A1 COL8A2
2 collagen-containing extracellular matrix GO:0062023 9.55 TNC TGFBI DCN COL9A1 COL8A2
3 collagen trimer GO:0005581 9.5 COL9A1 COL8A2 CD36
4 extracellular matrix GO:0031012 9.35 TNC TGFBI DCN COL9A1 COL8A2
5 basement membrane GO:0005604 8.92 TNC TGFBI COL9A1 COL8A2

Biological processes related to Interstitial Keratitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 9.26 TNC TGFBI COL8A2 CD36
2 extracellular matrix organization GO:0030198 9.02 TNC TGFBI DCN COL9A1 COL8A2

Molecular functions related to Interstitial Keratitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix structural constituent conferring tensile strength GO:0030020 9.32 COL9A1 COL8A2
2 extracellular matrix binding GO:0050840 9.26 TGFBI DCN
3 low-density lipoprotein particle binding GO:0030169 9.16 CRP CD36
4 collagen binding GO:0005518 9.13 TGFBI DCN ANTXR1
5 extracellular matrix structural constituent GO:0005201 8.92 TNC TGFBI COL9A1 COL8A2

Sources for Interstitial Keratitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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