Aliases & Classifications for Interstitial Keratitis

MalaCards integrated aliases for Interstitial Keratitis:

Name: Interstitial Keratitis 12 15 71

External Ids:

Disease Ontology 12 DOID:9857
ICD9CM 34 370.50
SNOMED-CT 67 1763009
ICD10 32 H16.30
UMLS 71 C0155088

Summaries for Interstitial Keratitis

Disease Ontology : 12 A connective tissue disease characterized by corneal scarring that develops from non-suppurative inflammation located in the corneal stroma, has symptom visual acuity loss, has symptom pain, and has symptom lacrimation.

MalaCards based summary : Interstitial Keratitis is related to cogan syndrome and congenital syphilis, and has symptoms including pain, visual acuity loss and lacrimation. An important gene associated with Interstitial Keratitis is DCN (Decorin), and among its related pathways/superpathways is A-beta Uptake and Degradation. Affiliated tissues include corneal stroma, eye and endothelial.

Wikipedia : 74 Interstitial keratitis (IK) is corneal scarring due to chronic inflammation of the corneal stroma.... more...

Related Diseases for Interstitial Keratitis

Diseases related to Interstitial Keratitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 143)
# Related Disease Score Top Affiliating Genes
1 cogan syndrome 33.0 SNORA59A PTPRJ
2 congenital syphilis 30.7 UTP6 CD40LG
3 aortitis 30.0 MRAP CD40LG
4 iridocyclitis 30.0 MRAP CD40LG
5 chorioretinitis 30.0 MRAP CD40LG
6 choroiditis 30.0 MRAP CD40LG
7 optic papillitis 29.7 MRAP CD40LG
8 corneal dystrophy, band-shaped 29.7 MRAP COL8A2
9 iritis 29.6 MRAP CD40LG
10 corneal disease 29.1 TGFBI DCN CRYAA COL8A2
11 eye disease 27.8 TGFBI MRAP CRYAA COL8A2 CD40LG
12 diffuse interstitial keratitis 12.5
13 idiopathic linear interstitial keratitis 12.4
14 late congenital syphilis 11.4
15 keratitis, hereditary 11.0
16 syphilis 10.5
17 odontogenic myxoma 10.4 DCN CD36
18 branchiootic syndrome 1 10.3
19 cornea plana 10.3 DCN CRYAA
20 osteochondrosis 10.2 COL9A1 CD36
21 yemenite deaf-blind hypopigmentation syndrome 10.2
22 intraocular pressure quantitative trait locus 10.2
23 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.2
24 uveitis 10.2
25 acrodermatitis chronica atrophicans 10.2 DCN CD40LG
26 osteochondritis dissecans 10.2 COL9A1 CD36
27 chancroid 10.2 CD40LG CD36
28 herpes simplex 10.2
29 babesiosis 10.2 CD40LG CD36
30 central retinal artery occlusion 10.2 CRYAA CD40LG
31 sarcoidosis 1 10.1
32 corneal edema 10.1
33 metaphyseal chondrodysplasia, schmid type 10.1 CRYAA COL8A2
34 cataract 24 10.1 MRAP CRYAA
35 ochronosis 10.1 MRAP CRYAA
36 volvulus of midgut 10.1
37 sensorineural hearing loss 10.1
38 sclerosing keratitis 10.1
39 hidradenitis suppurativa 10.1
40 hidradenitis 10.1
41 keratopathy 10.1
42 vasculitis 10.1
43 periostitis 10.1
44 legg-calve-perthes disease 10.0 COL9A1 CD40LG
45 macular dystrophy, dominant cystoid 10.0 MRAP CRYAA
46 stromal corneal dystrophy 10.0 TGFBI DCN
47 brittle cornea syndrome 2 10.0 DCN CRYAA COL8A2
48 asymptomatic neurosyphilis 10.0
49 onchocerciasis 10.0
50 lyme disease 10.0

Graphical network of the top 20 diseases related to Interstitial Keratitis:



Diseases related to Interstitial Keratitis

Symptoms & Phenotypes for Interstitial Keratitis

Symptoms:

12
  • pain
  • visual acuity loss
  • lacrimation

Drugs & Therapeutics for Interstitial Keratitis

Search Clinical Trials , NIH Clinical Center for Interstitial Keratitis

Genetic Tests for Interstitial Keratitis

Anatomical Context for Interstitial Keratitis

The Foundational Model of Anatomy Ontology organs/tissues related to Interstitial Keratitis:

19
Corneal Stroma

MalaCards organs/tissues related to Interstitial Keratitis:

40
Eye, Endothelial, Testes, T Cells, Retina, Bone Marrow, Bone

Publications for Interstitial Keratitis

Articles related to Interstitial Keratitis:

(show top 50) (show all 419)
# Title Authors PMID Year
1
Bilateral interstitial keratitis, erythema nodosum and atrial fibrillation as presenting signs of polyarteritis nodosa. 61
32140612 2020
2
Cogan syndrome: Descriptive analysis and clinical experience of 7 cases diagnosed and treated in two third level hospitals. 61
32571733 2020
3
Familial HLA-B*52 Vasculitis: Maternal, Atypical Cogan's Syndrome with Takayasu Arteritis-mimicking Aortitis and Filial Takayasu Arteritis. 61
32321889 2020
4
Interstitial Keratitis with Corneal Perforation as the Presenting Sign of Systemic Tuberculosis. 61
30806115 2020
5
[Bilateral Linear Interstitial Keratitis in a Patient with Unilateral Recurrent Herpetic Keratitis]. 61
32219778 2020
6
[Interstitial keratitis diagnosis and treatment (French translation of the article)]. 61
31870670 2020
7
Clinical Features of Ocular Syphilis: a Retrospective Clinical Study in an Italian Referral Centre. 61
32036734 2020
8
HTLV-1 in Ophthalmology. 61
32218778 2020
9
Late-onset Cogan's syndrome associated with large-vessel vasculitis. 61
28583785 2019
10
Hepatic vasculitis mimicking multiple liver abscesses in Cogan's Syndrome. 61
31308353 2019
11
Interstitial keratitis diagnosis and treatment. 61
31103357 2019
12
Syphilitic Interstitial Keratitis in a Patient Diagnosed With Sjögren's Syndrome. 61
29280828 2018
13
Characteristics of Linear Interstitial Keratitis by In Vivo Confocal Microscopy and Anterior Segment Optical Coherence Tomography. 61
29543661 2018
14
Scheimpflug-based Optical Densitometry for Assessment of Corneal Opacity: An Objective Method to Monitor Interstitial Keratitis. 61
29719653 2018
15
Keratoconus-like tomographic changes in a case of recurrent interstitial keratitis. 61
29516199 2018
16
Unilateral Posterior Interstitial Keratitis as a Clinical Presentation of Herpes Simplex Virus Disease. 61
29256984 2018
17
Interstitial Keratitis in Cogan's Syndrome. 61
29490187 2018
18
Anterior segment and external ocular disorders associated with HIV infections in the era of HAART in Chiang Mai University Hospital, a prospective descriptive cross sectional study. 61
29466424 2018
19
Syphilis. 61
30578519 2018
20
Optimal management of Cogan's syndrome: a multidisciplinary approach. 61
29317827 2018
21
Cogan syndrome: Characteristics, outcome and treatment in a French nationwide retrospective study and literature review. 61
29037902 2017
22
Bilateral interstitial keratitis with anterior stromal infiltrates associated with reactive arthritis. 61
28687682 2017
23
Congenital heart block and immune mediated sensorineural hearing loss: possible cross reactivity of immune response. 61
27913750 2017
24
Human T Cell Leukemia Virus Type 1 and Eye Diseases. 61
28263674 2017
25
Ocular Complications in Survivors of the Ebola Outbreak in Guinea. 61
27998698 2017
26
Autoimmune Ear Disease: Clinical and Diagnostic Relevance in Cogan's Sydrome. 61
28458810 2017
27
Histopathology of the Human Inner Ear in the Cogan Syndrome with Cochlear Implantation. 61
28848089 2017
28
[Ocular syphilis: 9 cases]. 61
27765446 2016
29
Non-human Immunodeficiency Virus-related Ocular Syphilis in a Korean Population: Clinical Manifestations and Treatment Outcomes. 61
27729756 2016
30
Epidemiological Profile of Patients Undergoing Urgent Corneal Transplant in a Referral Center in Northeastern Brazil. 61
27742299 2016
31
Hemorrhagic Descemet Membrane Detachment Following Syphilitic Interstitial Keratitis. 61
27227396 2016
32
Therapeutic Effect of 0.1% Topical Tacrolimus for Childhood Interstitial Keratitis Refractory to Cyclosporine. 61
26960587 2016
33
Histopathology of the Inner Ear in a Case With Recent Onset of Cogan's Syndrome: Evidence for Vasculitis. 61
26195577 2016
34
Herpes Simplex Virus Disease of the Anterior Segment in Children. 61
26266435 2015
35
Paraproteinemic Keratopathy: The Expanding Diversity of Clinical and Pathologic Manifestations. 61
26118999 2015
36
Do Unilateral Herpetic Stromal Keratitis and Neurotrophic Ulcers Cause Bilateral Dry Eye? 61
25933398 2015
37
[The Chameleon of Herpetic Keratitis - Diagnosis and Therapy]. 61
26084963 2015
38
Pathological Response of Northern Bobwhites to Oxyspirura petrowi Infections. 61
25723500 2015
39
OCULAR AND OSTEOARTICULAR TUBERCULOSIS IN A YOUNG PATIENT. CASE REPORT. 61
26978876 2015
40
Atypical Cogan's syndrome: a case report and summary of current treatment options. 61
25600284 2015
41
Clinics of ocular tuberculosis. 61
25615807 2015
42
[Bilateral herpetic keratouveitis in an immunocompetent patient]. 61
25443215 2015
43
SEROUS NEUROSENSORY RETINAL DETACHMENT ASSOCIATED WITH ATYPICAL COGAN SYNDROME: A CASE REPORT. 61
26426408 2015
44
[Description of the case of Cogan syndrome]. 61
26181159 2015
45
Descemet's scroll in syphilitic interstitial keratitis: a case report with anterior segment evaluation and a literature review. 61
26451126 2015
46
Inflammatory manifestations of HTLV-1 and their therapeutic options. 61
25340428 2014
47
Five-year outcome in immune-mediated scleritis. 61
25007956 2014
48
Cogan's syndrome--clinical guidelines and novel therapeutic approaches. 61
24385257 2014
49
Description of a new family with cryopyrin-associated periodic syndrome: risk of visual loss in patients bearing the R260W mutation. 61
24501247 2014
50
The Importance of FDG-PET/CT in Cogan's Syndrome. 61
24963451 2014

Variations for Interstitial Keratitis

Expression for Interstitial Keratitis

Search GEO for disease gene expression data for Interstitial Keratitis.

Pathways for Interstitial Keratitis

Pathways related to Interstitial Keratitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.13 CD40LG CD36

GO Terms for Interstitial Keratitis

Cellular components related to Interstitial Keratitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.73 TGFBI DCN COL9A1 COL8A2 CD40LG CD36
2 cell surface GO:0009986 9.62 PTPRJ CD40LG CD36 ANTXR1
3 collagen-containing extracellular matrix GO:0062023 9.46 TGFBI DCN COL9A1 COL8A2
4 collagen trimer GO:0005581 9.13 COL9A1 COL8A2 CD36
5 extracellular matrix GO:0031012 8.92 TGFBI DCN COL9A1 COL8A2

Biological processes related to Interstitial Keratitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of interleukin-12 production GO:0032735 8.96 CD40LG CD36
2 extracellular matrix organization GO:0030198 8.92 TGFBI DCN COL9A1 COL8A2

Molecular functions related to Interstitial Keratitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix structural constituent conferring tensile strength GO:0030020 9.26 COL9A1 COL8A2
2 extracellular matrix binding GO:0050840 9.16 TGFBI DCN
3 extracellular matrix structural constituent GO:0005201 9.13 TGFBI COL9A1 COL8A2
4 collagen binding GO:0005518 8.8 TGFBI DCN ANTXR1

Sources for Interstitial Keratitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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