MCID: INT067
MIFTS: 45

Interstitial Nephritis

Categories: Nephrological diseases
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Aliases & Classifications for Interstitial Nephritis

Summaries for Interstitial Nephritis

MalaCards based summary: Interstitial Nephritis, also known as nephritis, interstitial, is related to interstitial nephritis, karyomegalic and nephronophthisis 16. An important gene associated with Interstitial Nephritis is MT-TF (Mitochondrially Encoded TRNA-Phe (UUU/C)), and among its related pathways/superpathways are Ciliopathies and Joubert syndrome. The drugs Sodium citrate and Potassium citrate have been mentioned in the context of this disorder. Affiliated tissues include kidney, t cells and bone marrow, and related phenotypes are homeostasis/metabolism and renal/urinary system

Wikipedia: 75 Interstitial nephritis, also known as tubulointerstitial nephritis, is inflammation of the area of the... more...

Related Diseases for Interstitial Nephritis

Diseases related to Interstitial Nephritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 782)
# Related Disease Score Top Affiliating Genes
1 interstitial nephritis, karyomegalic 33.3 SNRNP27 FAN1 CEP164
2 nephronophthisis 16 32.2 MAPKBP1 INVS ANKS6
3 nephronophthisis 20 32.2 MAPKBP1 CEP164
4 danubian endemic familial nephropathy 32.1 OGA LCN2 B2M ALB
5 nephronophthisis 15 31.7 INVS CEP164
6 exanthem 31.5 ICOSLG ATP12A ALB ACE
7 acute kidney failure 31.3 UMOD REN LCN2 HAVCR1 B2M ALB
8 pyelonephritis 31.1 UMOD LCN2 ALB ACE
9 glomerulonephritis 31.0 REN LCN2 B2M ALB ACE
10 kidney disease 31.0 UMOD REN LCN2 INVS B2M ALB
11 nephrotic syndrome 30.9 REN LCN2 B2M ALB ACE
12 chronic pyelonephritis 30.8 UMOD REN B2M ALB ACE
13 nephronophthisis 30.8 UMOD MAPKBP1 INVS CEP164 ANKS6
14 granulomatous hepatitis 30.8 ALB ACE
15 acute pyelonephritis 30.8 OGA LCN2 HAVCR1 ALB
16 iga glomerulonephritis 30.7 REN ALB ACE
17 hypokalemia 30.7 REN MT-TF ALB ACE
18 renal tuberculosis 30.7 REN B2M ALB
19 membranoproliferative glomerulonephritis 30.6 REN ALB ACE
20 fanconi syndrome 30.6 UMOD OGA HAVCR1 B2M ALB
21 pyuria 30.6 LCN2 HAVCR1 B2M ATP4A ATP12A ALB
22 uremia 30.5 REN B2M ALB ACE
23 syphilis 30.5 B2M ALB ACE
24 juvenile nephronophthisis 30.5 MAPKBP1 INVS ANKS6
25 peptic ulcer disease 30.5 ATP4A ATP12A ALB ACE
26 rapidly progressive glomerulonephritis 30.4 REN ALB ACE
27 microvascular complications of diabetes 3 30.4 REN ALB ACE
28 kidney papillary necrosis 30.4 UMOD REN OGA HAVCR1 ALB ACE
29 chronic kidney disease 30.4 UMOD REN LCN2 INVS FAN1 B2M
30 alport syndrome 30.4 UMOD REN ALB ACE
31 urolithiasis 30.4 UMOD APRT ALB
32 acute kidney tubular necrosis 30.4 UMOD REN OGA LCN2 HAVCR1 B2M
33 henoch-schoenlein purpura 30.4 ICOSLG ALB ACE
34 anuria 30.3 REN LCN2 HAVCR1 ALB ACE
35 renal artery atheroma 30.3 REN ALB ACE
36 hyperuricemia 30.3 UMOD REN LCN2 HAVCR1 ALB
37 renal hypertension 30.3 REN ALB ACE
38 hypertensive nephropathy 30.2 ALB ACE
39 drug allergy 30.2 ATP4A ATP12A ALB ACE
40 infantile nephronophthisis 30.2 INVS ANKS6
41 hypoaldosteronism 30.2 REN ACE
42 hypersensitivity vasculitis 30.2 REN ICOSLG ALB ACE
43 duodenitis 30.2 ATP4A ATP12A ALB
44 meckel diverticulum 30.2 ATP4A ATP12A ALB
45 giardiasis 30.2 ATP4A ATP12A ALB
46 marginal zone b-cell lymphoma 30.2 ICOSLG ATP4A ATP12A
47 deficiency anemia 30.1 REN ICOSLG B2M ATP4A ATP12A ALB
48 hypersensitivity reaction type iii disease 30.1 ICOSLG ALB ACE
49 cholesterol embolism 30.1 REN LCN2 HAVCR1 ACE
50 urinary tract infection 30.1 UMOD REN LCN2 HAVCR1 ATP4A ATP12A

Graphical network of the top 20 diseases related to Interstitial Nephritis:



Diseases related to Interstitial Nephritis

Symptoms & Phenotypes for Interstitial Nephritis

MGI Mouse Phenotypes related to Interstitial Nephritis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.13 ACE ALB APRT ATP12A ATP4A B2M
2 renal/urinary system MP:0005367 10.06 ACE ALB ANKS6 APRT ATP12A FAN1
3 growth/size/body region MP:0005378 10.03 ACE ANKS6 APRT ATP12A ATP4A B2M
4 immune system MP:0005387 9.77 ACE ALB APRT ATP4A B2M FAN1
5 mortality/aging MP:0010768 9.47 ACE ALB ANKS6 APRT ATP4A B2M

Drugs & Therapeutics for Interstitial Nephritis

Drugs for Interstitial Nephritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sodium citrate Approved, Investigational 68-04-2 23431961
2
Potassium citrate Approved, Investigational, Vet_approved 866-84-2
3
Esomeprazole Approved, Investigational, Vet_approved 73590-58-6, 119141-88-7 9568614 4594
4
Citric acid Approved, Nutraceutical, Vet_approved 77-92-9 311
5 Citrate
6 Expectorants
7 diuretics
8 Proton Pump Inhibitors
9 Histamine H2 Antagonists

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Prednisolon Behandling Ved Akut Interstitiel Nefritis - et Randomiseret, Prospektivt Studie Recruiting NCT04376216 Phase 4 Prednisone
2 Xolair (Omalizumab) for Treatment of Drug-induced Acute Tubulointerstitial Nephritis (AIN) Withdrawn NCT01893658 Phase 2 Omalizumab;Prednisone
3 Effect of Urine Alkalinazation on Urinary Inflammatory Markers Analyzed Using Mass Spectrometry in Patients With Cystinuria Completed NCT03836144
4 Drug Utilization and Safety Events Among Children Using Esomeprazole, Other Proton Pump Inhibitors or H2-receptor Antagonists Completed NCT01338363
5 Phenotypical and Genetic Characterization of Adult Hereditary Chronic Tubulointerstitial Renal Diseases Completed NCT01312727
6 Self-administered Questionnaire to Evaluate Salt and Potassium Diet of Patients Followed in Nephrology - UniverSEL Study Completed NCT04195802
7 Biorepository to Support Research in Kidney Diseases Recruiting NCT04343417
8 Identification of the Causative Drug in Drug-induced Acute Interstitial Nephritis Not yet recruiting NCT05233241

Search NIH Clinical Center for Interstitial Nephritis

Cochrane evidence based reviews: nephritis, interstitial

Genetic Tests for Interstitial Nephritis

Genetic tests related to Interstitial Nephritis:

# Genetic test Affiliating Genes
1 Interstitial Nephritis 28

Anatomical Context for Interstitial Nephritis

Organs/tissues related to Interstitial Nephritis:

MalaCards : Kidney, T Cells, Bone Marrow, Neutrophil, Liver, B Cells, Bone

Publications for Interstitial Nephritis

Articles related to Interstitial Nephritis:

(show top 50) (show all 4302)
# Title Authors PMID Year
1
Tubulointerstitial nephritis associated with a novel mitochondrial point mutation. 5
11231339 2001
2
Effects of Tamm-Horsfall protein on polymorphonuclear leukocyte function. 53 62
15266028 2004
3
Three-dimensional structure of human adenine phosphoribosyltransferase and its relation to DHA-urolithiasis. 53 62
15196008 2004
4
Molecular cloning, expression, and chromosomal localization of a human tubulointerstitial nephritis antigen. 53 62
10652240 2000
5
[Structure and function of Tamm-Horsfall protein in human physiologic and pathologic states]. 53 62
10645146 1999
6
Composition of the sugar moiety of Tamm-Horsfall protein in patients with urinary diseases. 53 62
10436264 1999
7
Chronic renal failure in a mouse model of human adenine phosphoribosyltransferase deficiency. 53 62
9689017 1998
8
Granulomatous interstitial nephritis in a treatment-naïve patient with ulcerative colitis. 62
35311467 2022
9
Simultaneous subacute interstitial nephritis and anticoagulant-related nephropathy related to novel oral anticoagulants use. 62
35086437 2022
10
Interstitial nephritis without glomerulonephritis in ANCA-associated vasculitis: a case series and literature review. 62
35759125 2022
11
Renal sarcoidosis: Local renal turgescence, hypermetabolic 18F-FDG lesions, and granulomatous interstitial nephritis. 62
35598823 2022
12
Immunohistochemical detection and pathology of toxoplasmosis in Nigerian wild rats. 62
35306970 2022
13
The risk of renal comorbidities in celiac disease patients depends on the phenotype of celiac disease. 62
35713926 2022
14
Persistent DNA damage underlies tubular cell polyploidization and progression to chronic kidney disease in kidneys deficient in the DNA repair protein FAN1. 62
35931300 2022
15
A single heterozygous nonsense mutation in the TTC21B gene causes adult-onset nephronophthisis 12: A case report and review of literature. 62
36263627 2022
16
Pathomorphology, immunohistochemical, and molecular detection of an atypical porcine dermatitis and nephropathy syndrome (PDNS) due to PCV-2d-2 in naturally affected grower pigs of India. 62
36038085 2022
17
Development and external validation of a diagnostic model for biopsy-proven acute interstitial nephritis using electronic health record data. 62
34865148 2022
18
Concomitant Anti-GBM Glomerulonephritis and Acute Interstitial Nephritis Following Programmed Death Receptor-1 Blockade With Nivolumab. 62
36217512 2022
19
Acute interstitial nephritis related to SGLT-2 inhibitor. 62
34244379 2022
20
[Renal manifestations in rheumatoid arthritis and spondylarthritis]. 62
36264330 2022
21
Two case reports of immune checkpoint therapy on chromophobe renal cell carcinoma with sarcomatoid differentiation. 62
36186227 2022
22
Clinical and pathological characteristics of patients with acute kidney injury in Japan in whom kidney biopsy was performed: a cross-sectional analysis of the Japan Renal Biopsy Registry (J‑RBR). 62
35595865 2022
23
COVID-19 infection and renal injury: where is the place for acute interstitial nephritis disease? 62
35999963 2022
24
De-novo CMV infection manifesting as interstitial nephritis in a high-risk kidney recipient with concurrent urologic complications: lessons for the clinical nephrologist. 62
35749007 2022
25
Risk factors and prognostic role of renal adverse event in patients receiving immune checkpoint inhibitor therapy: analysis of data from a retrospective cohort study. 62
36267724 2022
26
Clarifying expression patterns by renal lesion using transcriptome analysis and vanin-1 as a potential novel biomarker for renal injury in chickens. 62
35901645 2022
27
Is treating with anti PD-1 to improve glomerular health come without a cost? Reply. 62
36136431 2022
28
Diagnosis and management of immune checkpoint inhibitor-associated acute kidney injury. 62
36168055 2022
29
Cilostazol-induced Acute Kidney Injury in A Patient With Diabetic Foot Ulcer: A Case Report and Review of Literature. 62
36178866 2022
30
Rapidly progressive IgA nephritis and sarcoidosis. 62
36178867 2022
31
Pantoprazole Induced Acute Interstitial Nephritis in a Patient with Diabetic Ketoacidosis. 62
36174588 2022
32
Lithium-induced nephropathy; One medication with multiple side effects: a case report. 62
36085030 2022
33
[A case of acute interstitial nephritis following the Pfizer-BioNTech COVID-19 vaccine]. 62
34219853 2022
34
Have we missed AINything? Acute interstitial nephritis in SARS-CoV-2 infection and vaccination. 62
35999962 2022
35
Renal infiltration of peripheral T-cell lymphoma, not otherwise specified, mimicking drug-induced acute interstitial nephritis. 62
36161392 2022
36
Primary biliary cholangitis presenting with Fanconi syndrome: an important phenotype. 62
35973749 2022
37
[A RARE COMBINATION OF DELAYED TYPE HYPERSENSITIVITY REACTIONS TO BETA-LACTAMS IN A PATIENT WITH MSSA BACTEREMIA]. 62
35979565 2022
38
Increased Renal Expression of Complement Components in Patients With Liver Diseases: Nonalcoholic Steatohepatitis, Alcohol-Associated, Viral Hepatitis, and Alcohol-Viral Combination. 62
35789393 2022
39
Pregnancy-related Acute Kidney Injury in Public Hospital in South India: Changing Trends. 62
36082728 2022
40
Acute Kidney Injury (AKI) in Young Synthetic Cannabinoids Abusers. 62
36009483 2022
41
Renal secondary hyperparathyroidism should be considered a differential diagnosis in forensic cases where animal abuse is suspected. 62
35984603 2022
42
Melatonin ameliorates renal dysfunction in glyphosate- and hard water-treated mice. 62
36068739 2022
43
Leishmania (L.) infantum BH401 strain induces classic renal lesions in dogs: Histological and confocal microscopy study. 62
35987406 2022
44
Should Corticosteroids Be Used to Treat Biopsy-Proven Drug-Induced Acute Interstitial Nephritis?: CON. 62
36176659 2022
45
Truth or dare: switching BRAF/MEK inhibitors after acute interstitial nephritis in a patient with metastatic melanoma - A case report and review of the literature. 62
35996969 2022
46
Heavy Chain/Light Chain Antibody Immunofluorescence to Identify Monoclonal Plasma Cells in a Case of Plasma Cell-Rich Acute Interstitial Nephritis. 62
35879978 2022
47
Should Corticosteroids be Used To Treat Biopsy-Proven Drug-Induced Acute Interstitial Nephritis?: COMMENTARY. 62
36178452 2022
48
Should Corticosteroids Be Used to Treat Biopsy-Proven Drug-Induced Acute Interstitial Nephritis?: PRO. 62
36176666 2022
49
Drug-Induced Acute Kidney Injury. 62
35273009 2022
50
Acute kidney injury associated with non-steroidal anti-inflammatory drugs. 62
35534373 2022

Variations for Interstitial Nephritis

ClinVar genetic disease variations for Interstitial Nephritis:

5
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 MT-TF m.608A>G SNV Pathogenic
30006 rs387906735 GRCh37: MT:608-608
GRCh38: MT:608-608
2 MT-TF m.616T>C SNV Pathogenic
9576 rs387906420 GRCh37: MT:616-616
GRCh38: MT:616-616

Expression for Interstitial Nephritis

Search GEO for disease gene expression data for Interstitial Nephritis.

Pathways for Interstitial Nephritis

Pathways related to Interstitial Nephritis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.18 INVS CEP164 ANKS6
2 10.67 INVS CEP164 ANKS6

GO Terms for Interstitial Nephritis

Cellular components related to Interstitial Nephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ciliary inversin compartment GO:0097543 8.8 INVS ANKS6

Biological processes related to Interstitial Nephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 kidney development GO:0001822 9.5 UMOD REN ANKS6 ACE
2 cellular sodium ion homeostasis GO:0006883 9.1 UMOD ATP4A ATP12A

Molecular functions related to Interstitial Nephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 P-type sodium:potassium-exchanging transporter activity GO:0005391 9.56 ATP4A ATP12A
2 P-type potassium:proton transporter activity GO:0008900 9.26 ATP4A ATP12A
3 P-type potassium transmembrane transporter activity GO:0008556 9.16 ATP4A ATP12A
4 enterobactin binding GO:1903981 8.92 LCN2 ALB

Sources for Interstitial Nephritis

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 24-Oct-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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