MCID: INT067
MIFTS: 47

Interstitial Nephritis

Categories: Nephrological diseases

Aliases & Classifications for Interstitial Nephritis

MalaCards integrated aliases for Interstitial Nephritis:

Name: Interstitial Nephritis 12 29 6 15
Nephritis, Interstitial 44 70
Renal Tubulo-Interstitial Disease 12
Nephritis, Tubulointerstitial 70
Nephritis Interstitial 54

Classifications:



External Ids:

Disease Ontology 12 DOID:1063
MeSH 44 D009395
NCIt 50 C26834
SNOMED-CT 67 28689008
UMLS 70 C0027707 C0041349

Summaries for Interstitial Nephritis

MalaCards based summary : Interstitial Nephritis, also known as nephritis, interstitial, is related to interstitial nephritis, karyomegalic and acute kidney failure. An important gene associated with Interstitial Nephritis is MT-TF (Mitochondrially Encoded TRNA-Phe (UUU/C)), and among its related pathways/superpathways are IL-6 signaling pathway and Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics. The drugs Prednisolone acetate and Methylprednisolone have been mentioned in the context of this disorder. Affiliated tissues include kidney, t cells and liver, and related phenotypes are homeostasis/metabolism and cardiovascular system

Wikipedia : 73 Interstitial nephritis, also known as tubulointerstitial nephritis, is inflammation of the area of the... more...

Related Diseases for Interstitial Nephritis

Diseases related to Interstitial Nephritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 647)
# Related Disease Score Top Affiliating Genes
1 interstitial nephritis, karyomegalic 33.4 MTMR10 FAN1 CEP164
2 acute kidney failure 31.8 UMOD REN ALB
3 proteinuria, chronic benign 31.5 REN ALB AGTR1 ACE
4 exanthem 31.4 PDCD1 CRP ALB ACE
5 acute kidney tubular necrosis 31.1 UMOD REN ALB ACE
6 glomerular disease 31.1 ALB ACE
7 acute pyelonephritis 31.0 CRP ALB ACE
8 kidney disease 31.0 UMOD REN CRP ALB AGTR1 AGT
9 nephrotic syndrome 31.0 REN CRP ALB AGT ACE
10 membranous nephropathy 30.9 TINAG ALB ACE
11 pyelonephritis 30.9 UMOD TIMP1 CRP ALB ACE
12 urinary tract infection 30.8 UMOD CRP ACE
13 granulomatous hepatitis 30.8 CRP ALB ACE
14 renal tuberculosis 30.8 REN CRP
15 hypokalemia 30.8 REN ALB ACE
16 chronic pyelonephritis 30.8 UMOD REN CRP ALB ACE
17 neuroretinitis 30.7 CRP ACE
18 renal fibrosis 30.7 REN ALB AGTR1 AGT
19 peptic ulcer disease 30.6 PTGS1 HRH2 CYP2C19
20 uremia 30.6 REN CRP ALB ACE
21 syphilis 30.6 CRP ALB ACE
22 iga glomerulonephritis 30.6 REN ALB AGTR1 AGT ACE
23 focal segmental glomerulosclerosis 30.6 ALB AGTR1 AGT ACE
24 pyelitis 30.5 UMOD REN CRP ALB ACE
25 nephronophthisis 30.5 UMOD TINAG INVS CEP164 ANKS6
26 optic papillitis 30.5 CRP ACE
27 microvascular complications of diabetes 3 30.4 REN ALB AGTR1 ACE
28 urticaria 30.4 PTGS1 HRH2 CRP ACE
29 drug allergy 30.4 CRP ALB ACE
30 bacteriuria 30.4 UMOD CRP ALB
31 hyperuricemia 30.4 UMOD REN CRP ALB
32 portal hypertension 30.4 ALB AGTR1 ACE
33 anuria 30.4 REN CRP ALB AGTR1 AGT ACE
34 hypoaldosteronism 30.3 REN ACE
35 severe cutaneous adverse reaction 30.3 PDCD1 CYP2C19 CRP
36 chronic kidney disease 30.3 UMOD REN INVS CRP ALB AGTR1
37 hypertensive nephropathy 30.2 ALB AGTR1 ACE
38 end stage renal disease 30.2 UMOD REN INVS CRP ALB AGTR1
39 acute cystitis 30.2 UMOD REN CRP ALB ACE
40 cholesterol embolism 30.2 REN CRP ACE
41 facial paralysis 30.2 CRP ALB ACE
42 hypersensitivity vasculitis 30.2 CRP ALB ACE
43 henoch-schoenlein purpura 30.2 CRP ALB ACE
44 mucormycosis 30.2 CYP2C19 CRP ALB
45 renal hypertension 30.1 REN ALB AGTR1 AGT ACE
46 urolithiasis 30.1 UMOD APRT ALB
47 gastric ulcer 30.1 PTGS1 HRH2 CYP2C19
48 migraine with or without aura 1 30.1 REN CRP ALB ACE
49 miliary tuberculosis 30.1 PDCD1 CRP ALB
50 hydronephrosis 30.1 TIMP1 REN CRP ALB

Graphical network of the top 20 diseases related to Interstitial Nephritis:



Diseases related to Interstitial Nephritis

Symptoms & Phenotypes for Interstitial Nephritis

MGI Mouse Phenotypes related to Interstitial Nephritis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.13 ACE AGT AGTR1 ALB APRT CEP164
2 cardiovascular system MP:0005385 10.1 ACE AGT AGTR1 ALB ANKS6 CRP
3 immune system MP:0005387 9.97 ACE AGT AGTR1 ALB APRT CRP
4 mortality/aging MP:0010768 9.8 ACE AGT AGTR1 ALB ANKS6 APRT
5 renal/urinary system MP:0005367 9.36 ACE AGT AGTR1 ALB APRT FAN1

Drugs & Therapeutics for Interstitial Nephritis

Drugs for Interstitial Nephritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
2
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
3
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
4
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
5
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
6
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
7
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
8 Hormone Antagonists Phase 4
9 Hormones Phase 4
10 Methylprednisolone Acetate Phase 4
11 glucocorticoids Phase 4
12 Antineoplastic Agents, Hormonal Phase 4
13 Anti-Inflammatory Agents Phase 4
14 Neurotransmitter Agents Phase 2, Phase 3
15 Melanocyte-Stimulating Hormones Phase 2, Phase 3
16 Adrenocorticotropic Hormone Phase 2, Phase 3
17 Endorphins Phase 2, Phase 3
18 Calcium, Dietary Phase 2, Phase 3
19 beta-Endorphin Phase 2, Phase 3
20
Calcium Nutraceutical Phase 2, Phase 3 7440-70-2 271
21
Esomeprazole Approved, Investigational 161973-10-0, 161796-78-7, 119141-88-7 4594 9568614
22
Potassium citrate Approved, Investigational, Vet_approved 866-84-2
23
Sodium citrate Approved, Investigational 68-04-2
24
Citric acid Approved, Nutraceutical, Vet_approved 77-92-9 311
25 Histamine H2 Antagonists
26 Proton Pump Inhibitors
27 Citrate
28 diuretics
29 Expectorants

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Prednisolon Behandling Ved Akut Interstitiel Nefritis - et Randomiseret, Prospektivt Studie Recruiting NCT04376216 Phase 4 Prednisone
2 ACTHAR GEL for Sarcoidosis-Associated Calcium Dysregulation: An Open-label Pilot Study Unknown status NCT02155803 Phase 2, Phase 3 ACTHAR Gel (adrenocorticotropic hormone)
3 Xolair (Omalizumab) for Treatment of Drug-induced Acute Tubulointerstitial Nephritis (AIN) Withdrawn NCT01893658 Phase 2 Omalizumab;Prednisone
4 Phenotypical and Genetic Characterization of Adult Hereditary Chronic Tubulointerstitial Renal Diseases Completed NCT01312727
5 Drug Utilization and Safety Events Among Children Using Esomeprazole, Other Proton Pump Inhibitors or H2-receptor Antagonists Completed NCT01338363
6 Self-administered Questionnaire to Evaluate Salt and Potassium Diet of Patients Followed in Nephrology - UniverSEL Study Completed NCT04195802
7 Effect of Urine Alkalinazation on Urinary Inflammatory Markers Analyzed Using Mass Spectrometry in Patients With Cystinuria Recruiting NCT03836144
8 Biorepository to Support Research in Kidney Diseases Recruiting NCT04343417

Search NIH Clinical Center for Interstitial Nephritis

Cochrane evidence based reviews: nephritis, interstitial

Genetic Tests for Interstitial Nephritis

Genetic tests related to Interstitial Nephritis:

# Genetic test Affiliating Genes
1 Interstitial Nephritis 29

Anatomical Context for Interstitial Nephritis

MalaCards organs/tissues related to Interstitial Nephritis:

40
Kidney, T Cells, Liver, Bone, Bone Marrow, Neutrophil, Skin

Publications for Interstitial Nephritis

Articles related to Interstitial Nephritis:

(show top 50) (show all 4052)
# Title Authors PMID Year
1
Tubulointerstitial nephritis associated with a novel mitochondrial point mutation. 6
11231339 2001
2
Effects of Tamm-Horsfall protein on polymorphonuclear leukocyte function. 61 54
15266028 2004
3
Three-dimensional structure of human adenine phosphoribosyltransferase and its relation to DHA-urolithiasis. 54 61
15196008 2004
4
Molecular cloning, expression, and chromosomal localization of a human tubulointerstitial nephritis antigen. 54 61
10652240 2000
5
[Structure and function of Tamm-Horsfall protein in human physiologic and pathologic states]. 61 54
10645146 1999
6
Composition of the sugar moiety of Tamm-Horsfall protein in patients with urinary diseases. 61 54
10436264 1999
7
Chronic renal failure in a mouse model of human adenine phosphoribosyltransferase deficiency. 54 61
9689017 1998
8
Ibrutinib-induced acute kidney injury via interstitial nephritis. 61
33567947 2021
9
Minimal change disease concurrent with acute interstitial nephritis after long-term use of sorafenib in a patient with renal cell carcinoma. 61
33389633 2021
10
ANCA-associated pauci-immune necrotizing glomerulonephritis during the treatment with pembrolizumab. 61
32691143 2021
11
[Etiologies and prognostic factors of acute interstitial nephritis]. 61
33485789 2021
12
Emergence and molecular characterization of pigeon Paramyxovirus-1 in non-native Eurasian collared doves (Streptopelia decaocto) in California, USA. 61
33727141 2021
13
Hypercalcemia and renal insufficiency – where can we start? 61
33774602 2021
14
A single-cell survey of the human glomerulonephritis. 61
33754492 2021
15
Spectrum of Kidney Involvement in Patients with Myelodysplastic Syndromes. 61
33732989 2021
16
Cocaine nephropathy: A rare cause of abnormal nephrograms. 61
33510825 2021
17
Clinical and morphologic spectrum of renal involvement in idiopathic hypereosinophilic syndrome. 61
33398597 2021
18
Florid Interstitial Hemorrhages: A Novel Feature of Amoxicillin-Clavulanate-Induced Acute Tubulointerstitial Nephritis. 61
33716294 2021
19
Acute interstitial nephritis due to sodium-glucose co-transporter 2 inhibitor empagliflozin. 61
33777384 2021
20
Drug induced acute interstitial nephritis in the critical care: should we consider it? 61
33325218 2021
21
Acute interstitial nephritis and PR3-ANCA following reintroduction of pembrolizumab: a case report. 61
33397120 2021
22
Progression of knee osteonecrosis on MRI. 61
33488898 2021
23
An enigmatic case of IgG4-related nephropathy and an updated review of the literature. 61
33683496 2021
24
Environmental Exposure of Wild Carnivores to Zoonotic Pathogens: Leptospira Infection in the First Free Living Wolf (Canis lupus Linnaeus, 1758) Found Dead in the Friuli Venezia Giulia Region. 61
33802554 2021
25
Lesions associated with Bartonella taylorii-like bacterium infection in a free-ranging, young-of-the-year raccoon from Prince Edward Island, Canada. 61
33463406 2021
26
Dipotassium glycyrrhizinate relieves leptospira-induced nephritis in vitro and in vivo. 61
33545326 2021
27
Proton Pump Inhibitors, Associated Complications, and Alternative Therapies: A Shifting Risk Benefit Ratio. 61
33560890 2021
28
Concomitant nephrotic syndrome and tubulointerstitial nephritis in a child with Epstein-Barr virus mononucleosis. 61
33541950 2021
29
Revising the Diagnosis of Idiopathic Uveitis by Peripheral Blood Transcriptomics. 61
32941857 2021
30
The unresolved epidemic of chronic kidney disease of uncertain origin (CKDu) around the world: A review and new insights. 61
33300865 2021
31
Infliximab for the treatment of patients with checkpoint inhibitor-associated acute tubular interstitial nephritis. 61
33643693 2021
32
Recovery of kidney function after dialysis initiation in children and adults in the US: A retrospective study of United States Renal Data System data. 61
33606673 2021
33
[Subacute kidney injury in a 40-year-old female Northern African patient]. 61
33616674 2021
34
Current concepts and advances in biomarkers of acute kidney injury. 61
33556265 2021
35
Identifying RNA Biomarkers and Molecular Pathways Involved in Multiple Subtypes of Uveitis. 61
33503442 2021
36
Recurrent acute interstitial nephritis: what lies beneath. 61
33564419 2021
37
The Collapsing Variant of Focal Segmental Glomerulosclerosis (FSGS) Secondary to Sarcoidosis, A Very Rare Case. 61
33492307 2021
38
The Use and Misuse of Proton Pump Inhibitors: An Opportunity for Deprescribing. 61
33321078 2021
39
FAN1, a DNA Repair Nuclease, as a Modifier of Repeat Expansion Disorders. 61
33579867 2021
40
Morphological findings in frozen non-neoplastic kidney tissues of patients with kidney cancer from large-scale multicentric studies on renal cancer. 61
33403511 2021
41
Acute interstitial nephritis and nephrogenic diabetes insipidus following treatment with sulfamethoxazole-trimethoprim and temozolomide. 61
32935422 2021
42
Renal involvement in eosinophilic granulomatosis with polyangiitis (EGPA): a multicentric retrospective study of 63 biopsy-proven cases. 61
32856066 2021
43
Acute interstitial nephritis following treatment with direct-acting antiviral agents in hepatitis C virus-infected patients: A case series. 61
32909545 2021
44
Primary Myelofibrosis-Related Renal Disorders Treated with a Janus Kinase Inhibitor. 61
33614736 2021
45
BK virus nephropathy in a heart transplant recipient. 61
33527977 2021
46
Potentially obesogenic diets alter metabolic and neurobehavioural parameters in Wistar rats: a comparison between two dietary models. 61
33120246 2021
47
Recurrent Renal Dysfunction Secondary to Probable Piperacillin-Tazobactam-Induced Acute Interstitial Nephritis. 61
32583672 2021
48
Hypertensive nephrosclerosis: wider kidney biopsy indications may be needed to improve diagnostics. 61
32613703 2021
49
A Systematic Review of Immune Checkpoint Inhibitor-Associated Glomerular Disease. 61
33426386 2021
50
The 2020 revised comprehensive diagnostic (RCD) criteria for IgG4-RD. 61
33274670 2021

Variations for Interstitial Nephritis

ClinVar genetic disease variations for Interstitial Nephritis:

6
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 MT-TF m.608A>G SNV Pathogenic 30006 rs387906735 GRCh37: MT:608-608
GRCh38: MT:608-608

Expression for Interstitial Nephritis

Search GEO for disease gene expression data for Interstitial Nephritis.

Pathways for Interstitial Nephritis

Pathways related to Interstitial Nephritis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.27 TIMP1 CRP AGT
2
Show member pathways
11.16 REN AGTR1 AGT ACE
3 10.76 REN AGTR1 AGT ACE

GO Terms for Interstitial Nephritis

Cellular components related to Interstitial Nephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.81 UMOD TINAG TIMP1 REN CRP APRT
2 extracellular space GO:0005615 9.61 UMOD TINAG TIMP1 REN CRP CEP164
3 ciliary inversin compartment GO:0097543 8.62 INVS ANKS6

Biological processes related to Interstitial Nephritis according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 regulation of blood pressure GO:0008217 9.56 REN PTGS1 AGT ACE
2 amyloid-beta metabolic process GO:0050435 9.52 REN ACE
3 angiotensin maturation GO:0002003 9.51 REN ACE
4 regulation of vasoconstriction GO:0019229 9.5 AGTR1 AGT ACE
5 positive regulation of cholesterol esterification GO:0010873 9.49 AGTR1 AGT
6 positive regulation of NAD(P)H oxidase activity GO:0033864 9.48 AGTR1 AGT
7 regulation of renal sodium excretion GO:0035813 9.46 AGTR1 AGT
8 regulation of blood vessel diameter by renin-angiotensin GO:0002034 9.43 AGTR1 AGT
9 regulation of renal output by angiotensin GO:0002019 9.4 AGT ACE
10 regulation of blood volume by renin-angiotensin GO:0002016 9.37 REN AGT
11 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 9.33 AGTR1 AGT ACE
12 renin-angiotensin regulation of aldosterone production GO:0002018 9.13 REN AGTR1 AGT
13 kidney development GO:0001822 9.1 UMOD REN ANKS6 AGTR1 AGT ACE

Molecular functions related to Interstitial Nephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 bradykinin receptor binding GO:0031711 8.62 AGTR1 ACE

Sources for Interstitial Nephritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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