MCID: INT067
MIFTS: 49

Interstitial Nephritis

Categories: Nephrological diseases

Aliases & Classifications for Interstitial Nephritis

MalaCards integrated aliases for Interstitial Nephritis:

Name: Interstitial Nephritis 12 15
Nephritis, Interstitial 44 73
Renal Tubulo-Interstitial Disease 12
Nephritis, Tubulointerstitial 73
Nephritis Interstitial 55

Classifications:



External Ids:

Disease Ontology 12 DOID:1063
MeSH 44 D009395
NCIt 50 C26834
SNOMED-CT 68 28689008

Summaries for Interstitial Nephritis

MalaCards based summary : Interstitial Nephritis, also known as nephritis, interstitial, is related to hypoaldosteronism and pyelitis. An important gene associated with Interstitial Nephritis is MT-TF (Mitochondrially Encoded TRNA Phenylalanine), and among its related pathways/superpathways are Peptide hormone metabolism and Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics. The drugs Pantoprazole and Anti-Ulcer Agents have been mentioned in the context of this disorder. Affiliated tissues include kidney, t cells and neutrophil, and related phenotypes are homeostasis/metabolism and liver/biliary system

Wikipedia : 76 Interstitial nephritis (or tubulo-interstitial nephritis) is a form of nephritis affecting the... more...

Related Diseases for Interstitial Nephritis

Diseases related to Interstitial Nephritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 287)
# Related Disease Score Top Affiliating Genes
1 hypoaldosteronism 32.2 ACE REN
2 pyelitis 31.3 CRP REN
3 pyelonephritis 31.2 UMOD CRP ALB ACE
4 urinary tract obstruction 30.7 ALB REN UMOD
5 vesicoureteral reflux 1 30.4 UMOD REN CRP AGT
6 iga glomerulonephritis 30.4 ACE ALB REN
7 membranous nephropathy 30.3 ACE ALB TINAG
8 acute kidney tubular necrosis 30.2 ALB UMOD
9 microvascular complications of diabetes 3 30.0 ALB AGT ACE
10 polycystic kidney disease 29.9 ACE ANKS6 REN
11 nephronophthisis 29.9 ANKS6 INVS UMOD
12 renal tuberculosis 29.8 CRP REN
13 systemic lupus erythematosus 29.6 ACE ALB CRP CYP2C19 PDCD1
14 hyperuricemia 29.6 CRP REN UMOD
15 kidney disease 29.5 UMOD REN CRP ALB AGT ACE
16 end stage renal failure 29.5 UMOD CRP ALB AGT ACE
17 chronic kidney failure 29.4 UMOD REN INVS CRP ALB AGT
18 myocardial infarction 29.2 REN CYP2C19 CRP ALB AGT ACE
19 interstitial nephritis, karyomegalic 12.9
20 megalocytic interstitial nephritis 12.7
21 danubian endemic familial nephropathy 11.5
22 nephronophthisis 2 11.2
23 nephronophthisis 15 11.2
24 nephronophthisis 16 11.2
25 nephronophthisis 20 11.2
26 chronic pyelonephritis 10.9
27 acute pyelonephritis 10.7
28 gitelman syndrome 10.7
29 hyperuricemia, pulmonary hypertension, renal failure, and alkalosis syndrome 10.7
30 hydronephrosis 10.7
31 renal infectious disease 10.7
32 transient pseudohypoaldosteronism 10.7
33 uveitis 10.5
34 igg4-related kidney disease 10.4
35 fibrosclerosis, multifocal 10.4
36 stricture or kinking of ureter 10.4
37 familial vesicoureteral reflux 10.4
38 hepatitis 10.4
39 nephrotic syndrome 10.4
40 glomerulonephritis 10.3
41 tubulointerstitial nephritis with uveitis 10.3
42 vasculitis 10.3
43 loeffler syndrome 10.3 ACE ALB
44 hyporeninemic hypoaldosteronism 10.3 ACE REN
45 juvenile nephronophthisis 10.3 ANKS6 INVS
46 renal artery obstruction 10.2 ACE REN
47 infantile nephronophthisis 10.2 ANKS6 INVS
48 benign essential hypertension 10.2 ALB REN
49 hypertension, diastolic 10.2 ACE REN
50 kidney papillary necrosis 10.2 ALB REN

Graphical network of the top 20 diseases related to Interstitial Nephritis:



Diseases related to Interstitial Nephritis

Symptoms & Phenotypes for Interstitial Nephritis

MGI Mouse Phenotypes related to Interstitial Nephritis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.9 ACE AGT ALB APRT CRP FAN1
2 liver/biliary system MP:0005370 9.5 ACE AGT ALB ANKS6 FAN1 INVS
3 renal/urinary system MP:0005367 9.28 ACE AGT ALB APRT FAN1 INVS

Drugs & Therapeutics for Interstitial Nephritis

Drugs for Interstitial Nephritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 91)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pantoprazole Approved Phase 4 102625-70-7 4679
2 Anti-Ulcer Agents Phase 4
3 Antacids Phase 4
4 Gastrointestinal Agents Phase 4,Phase 3
5 Proton Pump Inhibitors Phase 4
6
Vindesine Approved, Investigational Phase 3 59917-39-4, 53643-48-4 40839
7
Fludarabine Approved Phase 3 75607-67-9, 21679-14-1 30751
8
Doxorubicin Approved, Investigational Phase 3 23214-92-8 31703
9
Cyclophosphamide Approved, Investigational Phase 3 6055-19-2, 50-18-0 2907
10
leucovorin Approved Phase 3 58-05-9 6006 143
11
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
12
Etoposide Approved Phase 3 33419-42-0 36462
13
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3 1177-87-3
14
Ifosfamide Approved Phase 3 3778-73-2 3690
15
Daunorubicin Approved Phase 3 20830-81-3 30323
16
Methotrexate Approved Phase 3 59-05-2, 1959-05-2 126941
17
Pegaspargase Approved, Investigational Phase 3 130167-69-0
18
Cytarabine Approved, Investigational Phase 3 147-94-4 6253
19
Thioguanine Approved Phase 3 154-42-7 2723601
20
Prednisone Approved, Vet_approved Phase 3,Phase 2 53-03-2 5865
21
Vincristine Approved, Investigational Phase 3 57-22-7, 2068-78-2 5978
22
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
23
Doxil Approved June 1999 Phase 3 31703
24 Neurotransmitter Agents Phase 2, Phase 3
25 Melanocyte-Stimulating Hormones Phase 2, Phase 3
26 Calcium, Dietary Phase 2, Phase 3,Phase 1
27 beta-endorphin Phase 2, Phase 3
28 Hormones Phase 2, Phase 3,Phase 3
29 Bone Density Conservation Agents Phase 2, Phase 3,Phase 1
30 Endorphins Phase 2, Phase 3
31 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2, Phase 3,Phase 3
32 Adrenocorticotropic Hormone Phase 2, Phase 3
33 Hormone Antagonists Phase 2, Phase 3,Phase 3
34 Immunologic Factors Phase 3,Phase 1,Phase 2
35 Antirheumatic Agents Phase 3,Phase 1,Phase 2
36 Antineoplastic Agents, Phytogenic Phase 3,Phase 2
37 Antimitotic Agents Phase 3,Phase 2
38
Isophosphamide mustard Phase 3 0
39 Anti-Infective Agents Phase 3
40 Anti-Bacterial Agents Phase 3
41 Antineoplastic Agents, Hormonal Phase 3,Phase 2
42 Folic Acid Antagonists Phase 3
43 Antineoplastic Agents, Alkylating Phase 3
44 Peripheral Nervous System Agents Phase 3
45 Antiemetics Phase 3
46 Vitamin B Complex Phase 3
47 Immunosuppressive Agents Phase 3
48 6-Mercaptopurine Phase 3
49 Etoposide phosphate Phase 3
50 Antiviral Agents Phase 3

Interventional clinical trials:

(show all 17)
# Name Status NCT ID Phase Drugs
1 Stress Ulcer Prophylaxis in the Intensive Care Unit Completed NCT02467621 Phase 4 Pantoprazole
2 ACTHAR GEL for Sarcoidosis-Associated Calcium Dysregulation: An Open-label Pilot Study Unknown status NCT02155803 Phase 2, Phase 3 ACTHAR Gel (adrenocorticotropic hormone)
3 International Collaborative Treatment Protocol For Children And Adolescents With Acute Lymphoblastic Leukemia Active, not recruiting NCT01117441 Phase 3 PEG-L-asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;etoposide;ifosfamide;mercaptopurine;methotrexate;prednisone;thioguanine;vincristine sulfate;vindesine;daunoxome;fludarabine
4 Renal Effects of an Angiotensin Converting Enzyme Inhibitor in Adults With Chronic Kidney Disease of Uncertain Aetiology Unknown status NCT01624064 Phase 1, Phase 2 Enalapril;Calcium Supplement
5 Rituximab in IgG4-RD: A Phase 1-2 Trial Completed NCT01584388 Phase 1, Phase 2 Rituximab
6 Phase II Clinical Trial of NIVO-IPI-TAXANE in Untreated Metastatic NSCLC Recruiting NCT03573947 Phase 2 Nivolumab;Ipilimumab;Paclitaxel
7 Xolair (Omalizumab) for Treatment of Drug-induced Acute Tubulointerstitial Nephritis (AIN) Withdrawn NCT01893658 Phase 2 Omalizumab;Prednisone
8 Anti-BK Virus Immune Response and Kidney Transplantation Unknown status NCT01109186
9 Drug Utilization and Safety Events Among Children Using Esomeprazole, Other Proton Pump Inhibitors or H2-receptor Antagonists Completed NCT01338363
10 Hereditary Tubulointerstitial Nephritis Completed NCT01312727 Not Applicable
11 Evaluation of a Predictive Immunovirological Test Occurrence of BK Virus Nephropathy in Renal Transplant Completed NCT02049827 Not Applicable
12 A Prospective Cohort Study of IgG4RD in China Recruiting NCT01670695
13 Clinical Trial Investigating the Combination Therapy With Luminor DCB and iVolution Stent in TASC C and D Femoropopliteal Lesions Recruiting NCT03347383 Not Applicable
14 Retrospective Analysis of Renal Prognosis in Patients With Chronic Kidney Disease Recruiting NCT03201406
15 Observational Study of Nivolumab in Patients in Germany With Squamous Cell Carcinoma of the Head and Neck Progressing on or After Platinum-Based Therapy Recruiting NCT03114163
16 Renal Biopsy Unexplained Elevated Serum Creatinine Not yet recruiting NCT03586531
17 Study of Adverse Renal Effects of Immune Checkpoints Inhibitors Not yet recruiting NCT03316417

Search NIH Clinical Center for Interstitial Nephritis

Cochrane evidence based reviews: nephritis, interstitial

Genetic Tests for Interstitial Nephritis

Anatomical Context for Interstitial Nephritis

MalaCards organs/tissues related to Interstitial Nephritis:

41
Kidney, T Cells, Neutrophil, Liver, Lung, Bone, Thyroid

Publications for Interstitial Nephritis

Articles related to Interstitial Nephritis:

(show top 50) (show all 1029)
# Title Authors Year
1
Granulomatous interstitial nephritis associated with silica. ( 29346841 )
2018
2
Acute Kidney Injury due to granulomatous interstitial nephritis induced by tramadol administration. ( 29471961 )
2018
3
Chronic kidney disease mortality trends in selected Central America countries, 1997-2013: clues to an epidemic of chronic interstitial nephritis of agricultural communities. ( 29437864 )
2018
4
Chronic granulomatous interstitial nephritis and urothelial metaplasia associated with ritonavir-boosted atazanavir: a case study and literature review. ( 29941201 )
2018
5
Spontaneous perirenal urinoma induced by NSAID-associated acute interstitial nephritis. ( 29615838 )
2018
6
Membranoproliferative glomerulonephritis and interstitial nephritis in the setting of Epstein-Barr virus-related hemophagocytic syndromea8c. ( 29350173 )
2018
7
First case of acute granulomatous interstitial nephritis with immune reconstitution inflammatory syndrome in a patient with HIV coinfected with disseminated <i>Mycobacterium kansasii</i>. ( 29477993 )
2018
8
Acute cellular rejection with coexisting tuberculous interstitial nephritis in renal allograft. ( 29456234 )
2018
9
Drug-induced acute interstitial nephritis: Prospective randomized trial comparing oral steroids and high-dose intravenous pulse steroid therapy in guiding the treatment of this condition. ( 29970736 )
2018
10
Acute interstitial nephritis: a multifaceted disease. ( 29744094 )
2018
11
Interstitial Nephritis Secondary to Vedolizumab Treatment in Crohn Disease and Safe Rechallenge Using Steroids: A Case Report. ( 29162338 )
2018
12
Successful use of rituximab in glomerular basement membrane nephritis associated withA HIV interstitial nephritis secondary to Castleman diseasea8c. ( 29424337 )
2018
13
Granulomatous interstitial nephritis secondary to adalimumab therapy. ( 29644062 )
2018
14
Cefazolin-Related Acute Interstitial Nephritis with Associated Nephrotic-Range Proteinuria: A Case Report. ( 29633042 )
2018
15
Clinical Manifestations and Outcomes of Fluoroquinolone-Related Acute Interstitial Nephritis. ( 29157532 )
2018
16
A Case of SjAPgren's Syndrome Complicated with Interstitial Nephritis and Delayed Onset Autoimmune Hepatitis. ( 29731495 )
2018
17
Interstitial Nephritis Caused by Anorexia Nervosa in Young Male; A Case Report and Literature Review. ( 30046330 )
2018
18
Immunoallergic interstitial nephritis secondary to denosumab. ( 28115267 )
2018
19
A comparison of cystatin C concentrations between patients with chronic interstitial nephritis and glomerular diseases. ( 28187233 )
2018
20
Mott cell interstitial nephritis revealing Waldenström macroglobulinaemia. ( 29629483 )
2018
21
Karyomegalic interstitial nephritis in a renal allograft. ( 30040181 )
2018
22
Hepatitis, Interstitial Nephritis, and Pancreatitis in Association With Clozapine Treatment: A Systematic Review of Case Series and Reports. ( 30059436 )
2018
23
Baicalein alleviates tubular-interstitial nephritis in vivo and in vitro by down-regulating NF-κB and MAPK pathways. ( 30088539 )
2018
24
Adenovirus infection-A rare cause of interstitial nephritis in kidney transplant. ( 30097206 )
2018
25
Interstitial nephritis: Two pediatric cases with atypical radiological features. ( 30116463 )
2018
26
The effectiveness of corticosteroid compared to non-corticosteroid therapy for the treatment of drug-induced acute interstitial nephritis: A systematic review. ( 30129289 )
2018
27
Biopsy-proven acute interstitial nephritis due to fosfomycin in a child. ( 30134505 )
2018
28
Successful recovery of associated interstitial nephritis and focal segmental glomerulosclerosis in patients with HCV and HIV treated with sofosbuvir and daclatasvir and revision of literature. ( 30406000 )
2018
29
Azathioprine-induced interstitial nephritis in an anti-neutrophil cytoplasmic antibody (ANCA) myeloperoxidase (MPO) vasculitis patient. ( 30185363 )
2018
30
Dabigatran-Induced Acute Interstitial Nephritis: An Important Complication of Newer Oral Anticoagulation Agents. ( 30214652 )
2018
31
Adenovirus Interstitial Nephritis: An Unusual Cause for Early Graft Dysfunction. ( 30271002 )
2018
32
Granulomatous Interstitial Nephritis: A Rare Cause of Acute Kidney Injury. ( 30369386 )
2018
33
Duration of Treatment with Corticosteroids and Recovery of Kidney Function in Acute Interstitial Nephritis. ( 30397027 )
2018
34
Acute Interstitial Nephritis Induced by Citrullus Colocynthis. ( 29038395 )
2017
35
A case report of zinc phosphide poisoning: complicated by acute renal failure and tubulo interstitial nephritis. ( 28545504 )
2017
36
Acute granulomatous interstitial nephritis and acute rejection in a kidney transplant recipient after zoledronic acid therapy - a case report and review of the literature. ( 28655390 )
2017
37
A case of acute kidney injury caused by granulomatous interstitial nephritis associated with sarcoidosis. ( 29181823 )
2017
38
Granulomatous interstitial nephritis due to chronic lymphocytic leukemia: a case report. ( 29197349 )
2017
39
IgG4-Related Disease Manifesting as Interstitial Nephritis Accompanied by Hypophysitis. ( 28552902 )
2017
40
A Case Report of Acute Renal Failure as a Result of Light-Chain-Mediated Acute Tubular Interstitial Nephritis in a 30-Year-Old Combat Veteran. ( 29087890 )
2017
41
Acute Interstitial Nephritis Associated with Sofosbuvir and Daclatasvir. ( 28706960 )
2017
42
The increasing rates of acute interstitial nephritis in Australia: a single centre case series. ( 29089041 )
2017
43
Drug-Induced Acute Interstitial Nephritis. ( 28893923 )
2017
44
Novel oral anticoagulant and kidney injury: apixaban-related acute interstitial nephritis. ( 28847995 )
2017
45
Clinical profile and outcome of patients with biopsy-proven acute interstitial nephritis in Cape Town: a 10-year reviewa8c. ( 28438256 )
2017
46
Severe Acute Interstitial Nephritis: Response to Therapy With AntithymocyteA Globulin. ( 29142951 )
2017
47
Case 6: Skin Discoloration, Methemoglobinemia, and Acute Interstitial Nephritis in a 15-year-old Girl. ( 28765205 )
2017
48
Acute interstitial nephritis and DRESS syndrome without eosinophilia associated with cefepime. ( 28775112 )
2017
49
Alendronate sodium-induced interstitial nephritis. ( 29105273 )
2017
50
Cyclooxygenase-2 inhibitor-induced acute interstitial nephritis. ( 28536229 )
2017

Variations for Interstitial Nephritis

ClinVar genetic disease variations for Interstitial Nephritis:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 MT-TF m.608A> G single nucleotide variant Pathogenic rs387906735 GRCh37 Chromosome MT, 608: 608
2 MT-TF m.608A> G single nucleotide variant Pathogenic rs387906735 GRCh38 Chromosome MT, 608: 608

Expression for Interstitial Nephritis

Search GEO for disease gene expression data for Interstitial Nephritis.

Pathways for Interstitial Nephritis

GO Terms for Interstitial Nephritis

Cellular components related to Interstitial Nephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.23 ACE AGT ALB APRT CRP REN

Biological processes related to Interstitial Nephritis according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 kidney development GO:0001822 9.61 ACE AGT REN
2 blood vessel remodeling GO:0001974 9.51 ACE AGT
3 regulation of blood pressure GO:0008217 9.5 ACE AGT REN
4 regulation of vasoconstriction GO:0019229 9.49 ACE AGT
5 positive regulation of blood pressure GO:0045777 9.48 ACE AGT
6 positive regulation of superoxide anion generation GO:0032930 9.46 AGT CRP
7 amyloid-beta metabolic process GO:0050435 9.4 ACE REN
8 angiotensin maturation GO:0002003 9.37 ACE REN
9 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 9.26 ACE AGT
10 renin-angiotensin regulation of aldosterone production GO:0002018 9.16 AGT REN
11 regulation of blood volume by renin-angiotensin GO:0002016 8.96 AGT REN
12 regulation of renal output by angiotensin GO:0002019 8.62 ACE AGT

Sources for Interstitial Nephritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....