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MCID: INT067
MIFTS: 46

Interstitial Nephritis

Categories: Nephrological diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Interstitial Nephritis

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MalaCards integrated aliases for Interstitial Nephritis:

Name: Interstitial Nephritis 12 29 6 15
Nephritis, Interstitial 44 71
Renal Tubulo-Interstitial Disease 12
Nephritis, Tubulointerstitial 71
Nephritis Interstitial 54

Classifications:

MalaCards categories:
Anatomical: Nephrological diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:1063
MeSH 44 D009395
NCIt 50 C26834
SNOMED-CT 67 28689008
UMLS 71 C0027707 C0041349
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Summaries for Interstitial Nephritis

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MalaCards based summary : Interstitial Nephritis, also known as nephritis, interstitial, is related to acute kidney failure and proteinuria, chronic benign. An important gene associated with Interstitial Nephritis is MT-TF (Mitochondrially Encoded TRNA-Phe (UUU/C)), and among its related pathways/superpathways are IL6-mediated signaling events and ACE Inhibitor Pathway, Pharmacodynamics. The drugs Melanocyte-Stimulating Hormones and Neurotransmitter Agents have been mentioned in the context of this disorder. Affiliated tissues include kidney, t cells and bone marrow, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 74 Interstitial nephritis, also known as tubulointerstitial nephritis, is inflammation of the area of the... more...

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Related Diseases for Interstitial Nephritis

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Diseases related to Interstitial Nephritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 671)
# Related Disease Score Top Affiliating Genes
1 acute kidney failure 31.8 UMOD REN ALB
2 proteinuria, chronic benign 31.5 REN ALB AGTR1 ACE
3 glomerular disease 31.1 ALB ACE
4 acute kidney tubular necrosis 31.1 UMOD REN ALB ACE
5 acute pyelonephritis 31.0 CRP ALB ACE
6 exanthem 31.0 PDCD1 ICOSLG CRP ALB ACE
7 kidney disease 31.0 UMOD REN CRP ALB AGTR1 AGT
8 membranous nephropathy 30.9 TINAG ALB ACE
9 granulomatous hepatitis 30.8 CRP ALB ACE
10 renal tuberculosis 30.8 REN CRP
11 pyelonephritis 30.8 UMOD TIMP1 CRP ALB ACE
12 hypokalemia 30.8 REN ALB ACE
13 urinary tract infection 30.8 UMOD CRP ACE
14 chronic pyelonephritis 30.7 UMOD REN CRP ALB ACE
15 neuroretinitis 30.7 CRP ACE
16 peptic ulcer disease 30.6 PTGS1 HRH2 CYP2C19
17 uremia 30.6 REN CRP ALB ACE
18 syphilis 30.6 CRP ALB ACE
19 iga glomerulonephritis 30.6 REN ALB AGTR1 AGT ACE
20 focal segmental glomerulosclerosis 30.6 ALB AGTR1 AGT ACE
21 urticaria 30.5 PTGS1 HRH2 CRP
22 chronic kidney disease 30.5 UMOD REN INVS CRP ALB AGTR1
23 optic papillitis 30.5 CRP ACE
24 pyelitis 30.4 UMOD REN CRP ALB ACE
25 idiopathic nephrotic syndrome 30.4 ALB ACE
26 microvascular complications of diabetes 3 30.4 REN ALB AGTR1 ACE
27 igg4-related disease 30.4 PDCD1 ICOSLG CRP
28 portal hypertension 30.4 ALB AGTR1 ACE
29 bacteriuria 30.4 UMOD CRP ALB
30 anuria 30.4 REN CRP ALB AGTR1 AGT ACE
31 hyperuricemia 30.4 UMOD REN CRP ALB
32 hypoaldosteronism 30.3 REN ACE
33 severe cutaneous adverse reaction 30.3 PDCD1 CYP2C19 CRP
34 hypertensive nephropathy 30.3 ALB AGTR1 ACE
35 end stage renal disease 30.2 UMOD REN INVS CRP ALB AGTR1
36 cholesterol embolism 30.2 REN CRP ACE
37 facial paralysis 30.2 CRP ALB ACE
38 drug allergy 30.2 CRP ALB ACE
39 mucormycosis 30.2 CYP2C19 CRP ALB
40 acute cystitis 30.2 UMOD REN CRP ALB ACE
41 renal hypertension 30.2 REN ALB AGTR1 AGT ACE
42 panuveitis 30.2 ICOSLG CRP ACE
43 gastric ulcer 30.1 PTGS1 HRH2 CYP2C19
44 migraine with or without aura 1 30.1 REN CRP ALB ACE
45 miliary tuberculosis 30.1 PDCD1 CRP ALB
46 hydronephrosis 30.1 TIMP1 REN CRP ALB
47 pulmonary embolism 30.1 CRP ALB ACE
48 urolithiasis 30.0 UMOD APRT ALB
49 kawasaki disease 30.0 TIMP1 CRP ALB
50 pneumonia 29.9 HRH2 CRP ALB ACE

Graphical network of the top 20 diseases related to Interstitial Nephritis:



Diseases related to Interstitial Nephritis
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Symptoms & Phenotypes for Interstitial Nephritis

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MGI Mouse Phenotypes related to Interstitial Nephritis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.03 ACE AGT AGTR1 ALB ANKS6 CRP
2 homeostasis/metabolism MP:0005376 10.03 ACE AGT AGTR1 ALB APRT CEP164
3 immune system MP:0005387 9.77 ACE AGT AGTR1 ALB APRT CRP
4 renal/urinary system MP:0005367 9.36 ACE AGT AGTR1 ALB APRT FAN1
Sources

Drugs & Therapeutics for Interstitial Nephritis

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Drugs for Interstitial Nephritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Melanocyte-Stimulating Hormones Phase 2, Phase 3
2 Neurotransmitter Agents Phase 2, Phase 3
3 Adrenocorticotropic Hormone Phase 2, Phase 3
4 beta-Endorphin Phase 2, Phase 3
5 Calcium, Dietary Phase 2, Phase 3
6 Endorphins Phase 2, Phase 3
7
Calcium Nutraceutical Phase 2, Phase 3 7440-70-2 271
8
Esomeprazole Approved, Investigational 161796-78-7, 161973-10-0, 119141-88-7 9568614 4594
9
Sodium citrate Approved, Investigational 68-04-2
10
Potassium citrate Approved, Investigational, Vet_approved 866-84-2
11
Citric acid Approved, Nutraceutical, Vet_approved 77-92-9 311
12 Proton Pump Inhibitors
13 Histamine H2 Antagonists
14 Citrate
15 diuretics
16 Expectorants

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Prednisolon Behandling Ved Akut Interstitiel Nefritis - et Randomiseret, Prospektivt Studie Recruiting NCT04376216 Phase 4 Prednisone
2 ACTHAR GEL for Sarcoidosis-Associated Calcium Dysregulation: An Open-label Pilot Study Unknown status NCT02155803 Phase 2, Phase 3 ACTHAR Gel (adrenocorticotropic hormone)
3 Xolair (Omalizumab) for Treatment of Drug-induced Acute Tubulointerstitial Nephritis (AIN) Withdrawn NCT01893658 Phase 2 Omalizumab;Prednisone
4 Phenotypical and Genetic Characterization of Adult Hereditary Chronic Tubulointerstitial Renal Diseases Completed NCT01312727
5 Drug Utilization and Safety Events Among Children Using Esomeprazole, Other Proton Pump Inhibitors or H2-receptor Antagonists Completed NCT01338363
6 Self-administered Questionnaire to Evaluate Salt and Potassium Diet of Patients Followed in Nephrology - UniverSEL Study Completed NCT04195802
7 Biorepository to Support Research in Kidney Diseases Recruiting NCT04343417
8 Effect of Urine Alkalinazation on Urinary Inflammatory Markers Analyzed Using Mass Spectrometry in Patients With Cystinuria Recruiting NCT03836144

Search NIH Clinical Center for Interstitial Nephritis

Cochrane evidence based reviews: nephritis, interstitial

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Genetic Tests for Interstitial Nephritis

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Genetic tests related to Interstitial Nephritis:

# Genetic test Affiliating Genes
1 Interstitial Nephritis 29
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Anatomical Context for Interstitial Nephritis

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MalaCards organs/tissues related to Interstitial Nephritis:

40
Kidney, T Cells, Bone Marrow, Neutrophil, Skin, B Cells, Thyroid
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Publications for Interstitial Nephritis

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Articles related to Interstitial Nephritis:

(show top 50) (show all 4013)
# Title Authors PMID Year
1
Tubulointerstitial nephritis associated with a novel mitochondrial point mutation. 6
11231339 2001
2
Effects of Tamm-Horsfall protein on polymorphonuclear leukocyte function. 61 54
15266028 2004
3
Three-dimensional structure of human adenine phosphoribosyltransferase and its relation to DHA-urolithiasis. 54 61
15196008 2004
4
Molecular cloning, expression, and chromosomal localization of a human tubulointerstitial nephritis antigen. 61 54
10652240 2000
5
[Structure and function of Tamm-Horsfall protein in human physiologic and pathologic states]. 61 54
10645146 1999
6
Composition of the sugar moiety of Tamm-Horsfall protein in patients with urinary diseases. 54 61
10436264 1999
7
Chronic renal failure in a mouse model of human adenine phosphoribosyltransferase deficiency. 61 54
9689017 1998
8
Ibrutinib-induced acute kidney injury via interstitial nephritis. 61
33567947 2021
9
Cocaine nephropathy: A rare cause of abnormal nephrograms. 61
33510825 2021
10
Progression of knee osteonecrosis on MRI. 61
33488898 2021
11
Acute interstitial nephritis and PR3-ANCA following reintroduction of pembrolizumab: a case report. 61
33397120 2021
12
Recovery of kidney function after dialysis initiation in children and adults in the US: A retrospective study of United States Renal Data System data. 61
33606673 2021
13
Dipotassium glycyrrhizinate relieves leptospira-induced nephritis in vitro and in vivo. 61
33545326 2021
14
Current concepts and advances in biomarkers of acute kidney injury. 61
33556265 2021
15
Proton Pump Inhibitors, Associated Complications, and Alternative Therapies: A Shifting Risk Benefit Ratio. 61
33560890 2021
16
Concomitant nephrotic syndrome and tubulointerstitial nephritis in a child with Epstein-Barr virus mononucleosis. 61
33541950 2021
17
The unresolved epidemic of chronic kidney disease of uncertain origin (CKDu) around the world: A review and new insights. 61
33300865 2021
18
Balkan Endemic Nephropathy: An Autopsy Case Report. 61
33542864 2021
19
Lesions associated with Bartonella taylorii-like bacterium infection in a free-ranging, young-of-the-year raccoon from Prince Edward Island, Canada. 61
33463406 2021
20
Clinical and molecular findings in 37 Turkish patients with isolated methylmalonic acidemia. 61
33453710 2021
21
The Use and Misuse of Proton Pump Inhibitors: An Opportunity for Deprescribing. 61
33321078 2021
22
Acute interstitial nephritis and nephrogenic diabetes insipidus following treatment with sulfamethoxazole-trimethoprim and temozolomide. 61
32935422 2021
23
FAN1, a DNA Repair Nuclease, as a Modifier of Repeat Expansion Disorders. 61
33579867 2021
24
Minimal change disease concurrent with acute interstitial nephritis after long-term use of sorafenib in a patient with renal cell carcinoma. 61
33389633 2021
25
Morphological findings in frozen non-neoplastic kidney tissues of patients with kidney cancer from large-scale multicentric studies on renal cancer. 61
33403511 2021
26
The Collapsing Variant of Focal Segmental Glomerulosclerosis (FSGS) Secondary to Sarcoidosis, A Very Rare Case. 61
33492307 2021
27
Identifying RNA Biomarkers and Molecular Pathways Involved in Multiple Subtypes of Uveitis. 61
33503442 2021
28
Recurrent acute interstitial nephritis: what lies beneath. 61
33564419 2021
29
Infectious Bronchitis Virus Prevalence, Characterization and Strain Identification in California Backyard Chickens. 61
33400768 2021
30
Potentially obesogenic diets alter metabolic and neurobehavioural parameters in Wistar rats: a comparison between two dietary models. 61
33120246 2021
31
BK virus nephropathy in a heart transplant recipient. 61
33527977 2021
32
Clinical and morphologic spectrum of renal involvement in idiopathic hypereosinophilic syndrome. 61
33398597 2021
33
Renal involvement in eosinophilic granulomatosis with polyangiitis (EGPA): a multicentric retrospective study of 63 biopsy-proven cases. 61
32856066 2021
34
Acute interstitial nephritis following treatment with direct-acting antiviral agents in hepatitis C virus-infected patients: A case series. 61
32909545 2021
35
A Systematic Review of Immune Checkpoint Inhibitor-Associated Glomerular Disease. 61
33426386 2021
36
Hypertensive nephrosclerosis: wider kidney biopsy indications may be needed to improve diagnostics. 61
32613703 2021
37
IgG4-related nephritis and interstitial pulmonary disease complicated by invasive pulmonary fungal infection: a case report. 61
33430791 2021
38
The 2020 revised comprehensive diagnostic (RCD) criteria for IgG4-RD. 61
33274670 2021
39
Granulomatous interstitial nephritis in a patient with SARS-CoV-2 infection. 61
33419393 2021
40
Recurrent Renal Dysfunction Secondary to Probable Piperacillin-Tazobactam-Induced Acute Interstitial Nephritis. 61
32583672 2021
41
[Etiologies and prognostic factors of acute interstitial nephritis]. 61
33485789 2021
42
Chronic interstitial nephritis in agricultural communities (CINAC) and lysosomal tubulopathy: Is there a place for anti-oxidants? 61
33268000 2021
43
Only Hyperuricemia with Crystalluria, but not Asymptomatic Hyperuricemia, Drives Progression of Chronic Kidney Disease. 61
32938648 2020
44
Pathology of Ground Squirrels in a Research Colony. 61
33036668 2020
45
Clinical features of acute kidney injury in patients receiving dabrafenib and trametinib. 61
33355659 2020
46
Worsening proteinuria and renal function after intravitreal vascular endothelial growth factor blockade for diabetic proliferative retinopathy. 61
33391740 2020
47
Neutrophil Gelatinase-Associated Lipocalin (NGAL) Is Related with the Proteinuria Degree and the Microscopic Kidney Findings in Leishmania-Infected Dogs. 61
33322324 2020
48
Tubulointerstitial nephritis and uveitis syndrome with concurrent macular edema caused by granulomatous uveitis. 61
33363776 2020
49
[Renal granulomatous nephritis: Histopathological point of view]. 61
33277052 2020
50
Myositis and acute kidney injury in bacterial atypical pneumonia: Systematic literature review. 61
33139236 2020
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Variations for Interstitial Nephritis

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ClinVar genetic disease variations for Interstitial Nephritis:

6
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 MT-TF m.608A>G SNV Pathogenic 30006 rs387906735 MT:608-608 MT:608-608
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Expression for Interstitial Nephritis

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Search GEO for disease gene expression data for Interstitial Nephritis.
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Pathways for Interstitial Nephritis

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Pathways related to Interstitial Nephritis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
IL6-mediated signaling events 1
Show member pathways
 11.27 TIMP1 CRP AGT
2
ACE Inhibitor Pathway, Pharmacodynamics 60
Show member pathways
 11.16 REN AGTR1 AGT ACE
3
Renin secretion 36
10.76 REN AGTR1 AGT ACE
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GO Terms for Interstitial Nephritis

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Cellular components related to Interstitial Nephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.81 UMOD TINAG TIMP1 REN CRP APRT
2 extracellular space GO:0005615 9.61 UMOD TINAG TIMP1 REN CRP CEP164
3 ciliary inversin compartment GO:0097543 8.62 INVS ANKS6

Biological processes related to Interstitial Nephritis according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 regulation of blood pressure GO:0008217 9.56 REN PTGS1 AGT ACE
2 amyloid-beta metabolic process GO:0050435 9.52 REN ACE
3 angiotensin maturation GO:0002003 9.51 REN ACE
4 regulation of vasoconstriction GO:0019229 9.5 AGTR1 AGT ACE
5 positive regulation of cholesterol esterification GO:0010873 9.49 AGTR1 AGT
6 positive regulation of NAD(P)H oxidase activity GO:0033864 9.48 AGTR1 AGT
7 regulation of renal sodium excretion GO:0035813 9.46 AGTR1 AGT
8 regulation of blood vessel diameter by renin-angiotensin GO:0002034 9.43 AGTR1 AGT
9 regulation of renal output by angiotensin GO:0002019 9.4 AGT ACE
10 regulation of blood volume by renin-angiotensin GO:0002016 9.37 REN AGT
11 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 9.33 AGTR1 AGT ACE
12 renin-angiotensin regulation of aldosterone production GO:0002018 9.13 REN AGTR1 AGT
13 kidney development GO:0001822 9.1 UMOD REN ANKS6 AGTR1 AGT ACE

Molecular functions related to Interstitial Nephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 bradykinin receptor binding GO:0031711 8.62 AGTR1 ACE
Sources

Sources for Interstitial Nephritis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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