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IDD
MCID: INT146
MIFTS: 65

Intervertebral Disc Disease (IDD)

Categories: Bone diseases, Genetic diseases, Muscle diseases, Rare diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Intervertebral Disc Disease

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MalaCards integrated aliases for Intervertebral Disc Disease:

Name: Intervertebral Disc Disease 58 54 26 76 56 41
Intervertebral Disc Degeneration 54 26 45 74
Intervertebral Disc Disorder 26 30 6 74
Lumbar Disc Disease 58 76 56 74
Idd 58 54 26 76
Intervertebral Disc Disease, Susceptibility to 58 13 6
Lumbar Disc Degeneration 58 76 17
Lumbar Disc Herniation 58 76 17
Lumbar Disc Herniation, Susceptibility to 58 6
Lumbar Disc Disease, Susceptibility to 58 6
Intervertebral Disc Displacement 45 17
Lumbar Disc Degeneration, Susceptibility to 6
Degeneration of Lumbar Intervertebral Disc 74
Abnormality of the Intervertebral Disk 30
Intervertebral Disk Degeneration 26
Intervertebral Disk Displacement 74
Disorder of Intervertebral Disc 26
Intervertebral Disk Disease 76
Degenerative Disc Disease 54
Discogenic Disorder 26
Discogenic Disease 26
Ldd 76
Ldh 76

Classifications:

MalaCards categories:
Global: Genetic diseases Rare diseases
Anatomical: Bone diseases Muscle diseases
See all MalaCards categories (disease lists)
ICD10: 34


Sources

Summaries for Intervertebral Disc Disease

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NIH Rare Diseases : 54 Intervertebral disc disease (IDD) is a common musculoskeletal condition that primarily affects the back. It is characterized by intervertebral disc herniation and/or sciatic pain (sciatica) and is a primary cause of low back pain, affecting about 5% of individuals. Both environmental and genetic factors are thought to predispose an individual to developing the condition. Treatment for IDD may include physical therapy, pain medications, and sometimes surgical intervention such as discectomy or spinal fusion.

MalaCards based summary : Intervertebral Disc Disease, also known as intervertebral disc degeneration, is related to radiculopathy and osteoarthritis, and has symptoms including sciatica An important gene associated with Intervertebral Disc Disease is COL9A3 (Collagen Type IX Alpha 3 Chain), and among its related pathways/superpathways are Phospholipase-C Pathway and PI3K-Akt signaling pathway. The drugs Norepinephrine and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and spinal cord, and related phenotypes are immune system and cardiovascular system

Genetics Home Reference : 26 Intervertebral disc disease is a common condition characterized by the breakdown (degeneration) of one or more of the discs that separate the bones of the spine (vertebrae), causing pain in the back or neck and frequently in the legs and arms. The intervertebral discs provide cushioning between vertebrae and absorb pressure put on the spine.

OMIM : 58 Lumbar disc disease is caused by degeneration of intervertebral discs of the lumbar spine. One of the most common musculoskeletal disorders, it has strong genetic determinants (Matsui et al., 1998; Battie et al., 1995; Sambrook et al., 1999). (603932)

UniProtKB/Swiss-Prot : 76 Intervertebral disc disease: A common musculo-skeletal disorder caused by degeneration of intervertebral disks of the lumbar spine. It results in low-back pain and unilateral leg pain.

Sources

Related Diseases for Intervertebral Disc Disease

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Diseases related to Intervertebral Disc Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 345)
# Related Disease Score Top Affiliating Genes
1 radiculopathy 30.9 IL1A IL6
2 osteoarthritis 30.1 ASPN CILP IL1B IL6
3 degenerative disc disease 30.1 ASPN COL9A3 VDR
4 spondylosis 29.9 IL1B VDR
5 osteomyelitis 29.7 IL1A IL1B IL6
6 meningitis 29.6 IL1B IL6 MMP9
7 arthritis 29.6 IL1A IL1B IL6 MMP9
8 osteoporosis 29.2 IL1A IL1B IL6 VDR
9 rheumatoid arthritis 28.8 IL1A IL1B IL2 IL6 MMP9
10 prostatitis 28.7 IL1B IL2 IL6 VDR
11 lactate dehydrogenase b deficiency 11.9
12 cowden syndrome 1 11.8
13 lactate dehydrogenase deficiency 11.8
14 spondyloepiphyseal dysplasia with congenital joint dislocations 11.3
15 short stature and advanced bone age, with or without early-onset osteoarthritis and/or osteochondritis dissecans 11.2
16 follicular lymphoma 11.1
17 testicular seminoma 11.1
18 fanconi-bickel syndrome 11.1
19 glycogen storage disease due to lactate dehydrogenase deficiency 11.1
20 cauda equina syndrome 10.7
21 spinal stenosis 10.5
22 multiple epiphyseal dysplasia due to collagen 9 anomaly 10.4 COL9A2 COL9A3
23 epiphyseal dysplasia, multiple, 2 10.4 COL9A2 COL9A3
24 epiphyseal dysplasia, multiple, 3 10.4 COL9A2 COL9A3
25 epiphyseal dysplasia, multiple, 4 10.4 COL9A2 COL9A3
26 pain - chronic 10.4
27 epiphyseal dysplasia, multiple, 5 10.4 COL9A2 COL9A3
28 global developmental delay, absent or hypoplastic corpus callosum, and dysmorphic facies 10.3
29 bone mineral density quantitative trait locus 8 10.3
30 bone mineral density quantitative trait locus 15 10.3
31 diabetic foot ulcers 10.3 IL6 MMP9
32 acute transverse myelitis 10.3 IL6 MMP9
33 transverse myelitis 10.3 IL6 MMP9
34 vitreoretinal degeneration 10.2 COL11A1 COL9A2
35 recurrent corneal erosion 10.2 IL1B IL6
36 bagassosis 10.2 IL1B IL6
37 alkaptonuria 10.2
38 foot drop 10.2
39 periodontitis, chronic 10.2 IL1B IL6
40 pneumococcal meningitis 10.2 COL11A1 MMP9
41 glossitis 10.2 IL1B IL6
42 photokeratitis 10.2 IL6 MMP9
43 laryngitis 10.2 IL1B IL6
44 funisitis 10.2 IL1B IL6
45 euthyroid sick syndrome 10.2 IL1B IL6
46 acute vascular insufficiency of intestine 10.2 IL1B IL6
47 ascaris lumbricoides infection 10.2 IL1B IL6
48 osteosclerotic myeloma 10.2 IL1B IL6
49 corneal ulcer 10.2 IL1B MMP9
50 poems syndrome 10.2 IL1B IL6

Comorbidity relations with Intervertebral Disc Disease via Phenotypic Disease Network (PDN):


Acute Cystitis Bronchitis
Chronic Myocardial Ischemia Deficiency Anemia
Esophagitis Heart Disease
Hypertension, Essential Ischemic Heart Disease
Osteoporosis

Graphical network of the top 20 diseases related to Intervertebral Disc Disease:



Diseases related to Intervertebral Disc Disease
Sources

Symptoms & Phenotypes for Intervertebral Disc Disease

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Clinical features from OMIM:

603932

UMLS symptoms related to Intervertebral Disc Disease:


sciatica

MGI Mouse Phenotypes related to Intervertebral Disc Disease:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.92 COL11A1 IL1A IL1B IL2 IL6 MMP9
2 cardiovascular system MP:0005385 9.91 IL1A IL1B IL2 IL6 MMP9 THBS2
3 integument MP:0010771 9.73 IL1A IL1B IL6 MMP9 THBS2 VDR
4 limbs/digits/tail MP:0005371 9.55 COL11A1 COL9A2 MMP9 THBS2 VDR
5 neoplasm MP:0002006 9.43 IL1A IL1B IL2 IL6 MMP9 THBS2
6 skeleton MP:0005390 9.17 COL11A1 COL9A2 IL1B IL6 MMP9 THBS2
Sources

Drugs & Therapeutics for Intervertebral Disc Disease

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Drugs for Intervertebral Disc Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 163)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Norepinephrine Approved Phase 4 51-41-2 439260
2
Dopamine Approved Phase 4 62-31-7, 51-61-6 681
3
Eplerenone Approved Phase 4 107724-20-9 150310 443872
4
Oxycodone Approved, Illicit, Investigational Phase 4,Not Applicable 76-42-6 5284603
5
Morphine Approved, Investigational Phase 4,Phase 3,Not Applicable 57-27-2 5288826
6
Bupivacaine Approved, Investigational Phase 4,Not Applicable,Early Phase 1 2180-92-9, 38396-39-3 2474
7 Dopamine Agents Phase 4
8 Duloxetine Hydrochloride Phase 4
9 Antidepressive Agents Phase 4
10 Neurotransmitter Uptake Inhibitors Phase 4
11 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
12 Psychotropic Drugs Phase 4,Not Applicable
13 Neurotransmitter Agents Phase 4,Phase 3,Not Applicable
14 Analgesics Phase 4,Phase 3,Not Applicable
15 Serotonin and Noradrenaline Reuptake Inhibitors Phase 4
16
s 1 (combination) Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
17 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Not Applicable,Early Phase 1
18 Diuretics, Potassium Sparing Phase 4,Phase 3,Phase 2,Not Applicable
19 Hormone Antagonists Phase 4,Phase 3,Not Applicable,Early Phase 1
20 Hormones Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
21 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
22 Anesthetics Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
23 Anesthetics, Local Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
24 Pharmaceutical Solutions Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
25 Antihypertensive Agents Phase 4,Not Applicable
26 diuretics Phase 4
27 Mineralocorticoid Receptor Antagonists Phase 4
28 Natriuretic Agents Phase 4
29 Mineralocorticoids Phase 4
30 Narcotics Phase 4,Phase 3,Not Applicable
31 Analgesics, Opioid Phase 4,Phase 3,Not Applicable
32
Serotonin Investigational, Nutraceutical Phase 4,Not Applicable 50-67-9 5202
33
Methylprednisolone Approved, Vet_approved Phase 3,Not Applicable,Early Phase 1 83-43-2 6741
34
Lidocaine Approved, Vet_approved Phase 3,Phase 2,Not Applicable,Early Phase 1 137-58-6 3676
35
Methylprednisolone hemisuccinate Approved Phase 3,Not Applicable,Early Phase 1 2921-57-5
36
Prednisolone Approved, Vet_approved Phase 3,Not Applicable,Early Phase 1 50-24-8 5755
37
Prednisolone phosphate Approved, Vet_approved Phase 3,Not Applicable,Early Phase 1 302-25-0
38
Hyaluronic acid Approved, Vet_approved Phase 3,Phase 1,Phase 2 9004-61-9 53477741
39
tannic acid Approved Phase 3,Not Applicable 1401-55-4
40
Benzocaine Approved, Investigational Phase 3,Not Applicable 94-09-7, 1994-09-7 2337
41
Racepinephrine Approved Phase 3 329-65-7 838
42
Epinephrine Approved, Vet_approved Phase 3 51-43-4 5816
43
Ropivacaine Approved Phase 3 84057-95-4 71273 175805
44
Infliximab Approved Phase 3 170277-31-3
45
Buprenorphine Approved, Illicit, Investigational, Vet_approved Phase 3 52485-79-7 40400 644073
46
Tramadol Approved, Investigational Phase 3,Not Applicable 27203-92-5 33741
47
Calcium Approved, Nutraceutical Phase 3,Phase 1,Phase 2,Not Applicable 7440-70-2 271
48
Prednisolone hemisuccinate Experimental Phase 3,Not Applicable,Early Phase 1 2920-86-7
49 Anti-Arrhythmia Agents Phase 3,Phase 2,Not Applicable
50 Autonomic Agents Phase 3,Not Applicable,Early Phase 1

Interventional clinical trials:

(show top 50) (show all 338)
# Name Status NCT ID Phase Drugs
1 Duloxetine as an Analgesic Agent in Patients Undergoing Elective Spine Surgery Unknown status NCT02535000 Phase 4 Duloxetine;Placebo
2 A Prospective Study of the InterFuse T(tm), Unknown status NCT02678130 Phase 4
3 Study to Investigate the Performance of Cervical Arthroplasty for the Treatment of Cervical Degenerative Disc Disease Terminated NCT00700739 Phase 4
4 Efficacy and Safety of Expandable Spacer in the Treatment of Degenerative Disc Disease Using the Minimally Invasive Transforaminal Lumbar Interbody Fusion Surgical Approach Completed NCT02075554 Phase 4
5 Comparison of IDD Therapy and Non-surgical Treatment for Low Back Pain Caused by Degenerative Disc Disease Completed NCT00165893 Phase 4
6 Post-Market Surveillance Study of the TM Ardis Interbody Fusion System Completed NCT02429908 Phase 4
7 Eplerenone as a Supplement to Epidural Steroid Injections Recruiting NCT03418649 Phase 4 Eplerenone 50 Mg Tab;Placebo Oral Tablet
8 NanoFUSE® PL Gutter PMCF Not yet recruiting NCT03751943 Phase 4
9 Evaluation of Fusion Rate of Anterior Cervical Discectomy and Fusion (ACDF) Using Cervios ChronOs™ and Bonion™ Completed NCT01615328 Phase 4
10 Study Of Disc Anaesthesia For The Preoperative Diagnosis Of Chronic Lower Back Pain Completed NCT00443781 Phase 4
11 BIO4 Clinical Case Study: Cervical Spine Active, not recruiting NCT03077204 Phase 4
12 Efficacy of Using Solum IV and BMC With GFC in TLIF Withdrawn NCT03223701 Phase 4
13 Opioid Treatment for Chronic Low Back Pain and the Impact of Mood Symptoms Completed NCT01502644 Phase 4 Oxycodone;Morphine;Placebo
14 Caudal Epidural Steroid Injections for Low Back Pain/Sciatic Lumbar Pain Completed NCT01407913 Phase 4
15 A Prospective Study to Compare Bupivacaine and Exparel Versus Bupivacaine or Exparel Alone for Postoperative Pain Relief Recruiting NCT03514277 Phase 4 Exparel;Bupivacaine
16 Wallis Stabilization System for Low Back Pain Unknown status NCT00484458 Phase 3
17 Wallis Mechanical Normalization System for Low Back Pain Unknown status NCT00134537 Phase 3
18 Assessment of the Efficacy of an Intradiscal Injection of Corticoids in Modic I Discopathies. Unknown status NCT01694134 Phase 3 Hydrocortancyl.;Lidocaine
19 A Study of SI-6603 in Patients With Lumbar Disc Herniation Completed NCT02421601 Phase 3 Condoliase
20 A Study of SI-6603 in Patients With Lumbar Disc Herniation Completed NCT01941563 Phase 3 Condoliase;placebo
21 XL TDR® eXtreme Lateral Total Disc Replacement for the Treatment of Lumbar Degenerative Disc Disease (DDD) Completed NCT00927238 Phase 3
22 rhBMP-2/CRM/CD HORIZON® Spinal System Pivotal Study Completed NCT00707265 Phase 3
23 CHARITÉ™ Artificial Disc Compared to Anterior Interbody Fusion for Treatment of Degenerative Disc Disease Completed NCT00215306 Phase 3
24 Safety and Efficacy Study of Healos as a Bone Replacement to Treat Degenerative Disc Disease Completed NCT00316121 Phase 3
25 Efficacy of Intradiscal Injection of BM-MSC in Subjects With Chronic Low Back Pain (LBP) Due to Lumbar Degenerative Disc Disease (DDD) Unresponsive Not yet recruiting NCT03737461 Phase 2, Phase 3 Allogenic BM-MSCs Injection
26 Titanium Surgical Mesh and MOSS-Miami Screws for Lumbar Fusion. Completed NCT00215319 Phase 3
27 MAVERICK™ Total Disc Replacement- Pivotal Study Completed NCT00635843 Phase 3
28 Cervical I/F Cage for Anterior Cervical Fusion Completed NCT00215293 Phase 3
29 Study of Safety & Effectiveness of PRESTIGE® LP Cervical Disc vs. Anterior Cervical Fusion in Cervical DDD Completed NCT00667459 Phase 3
30 Placebo-controlled Study to Evaluate Rexlemestrocel-L Alone or Combined With Hyaluronic Acid in Subjects With Chronic Low Back Pain Active, not recruiting NCT02412735 Phase 3 rexlemestrocel-L;rexlemestrocel-L + HA;Placebo
31 Prospective Study of Thoracolumbar Spinal Fusion Graft Active, not recruiting NCT02297256 Phase 3
32 Prospective, Multi-center Study to Assess Posterolateral Fusion Using FIBERGRAFT Enrolling by invitation NCT03884283 Phase 3
33 Peri-Incisional Drug Injection in Lumbar Spine Surgery Not yet recruiting NCT03513445 Phase 3 Morphine;Epinephrine;naropin
34 BackToBasic: Infliximab in Chronic Low Back Pain and Modic Changes Recruiting NCT03704363 Phase 3 Biosimilar Infliximab
35 Treatment of Symptomatic Lumbar Internal Disc Disruption (IDD) With the Biostat® System Terminated NCT01011816 Phase 3 Saline
36 Wallis Interspinous Dynamic Stability System for Lumbar Disc Herniation: a Prospective Study Completed NCT01824108 Phase 3
37 Impact of Local Steroid Application in Extreme Lateral Lumbar Interbody Fusion Recruiting NCT03327272 Phase 3 Methylprednisolone;Saline
38 Performance of the Hedrocel(R) Cervical Fusion Device Completed NCT00758758 Phase 3
39 Evaluation of Outcomes With Amniotic Fluid for Musculoskeletal Conditions Musculoskeletal Conditions Recruiting NCT03390920 Phase 2, Phase 3
40 NORSPAN Transdermal Patches Phase III Study In Non-Cancer Pain Completed NCT01476774 Phase 3 Buprenorphine Transdermal System;Buprenorphine Transdermal System
41 Pilot Study to Assess Safety/Prelimary Effectiveness of Prefix in Subjects With Degenerative Disc Disease (DDD) Undergoing Spine Fusion Surgery Unknown status NCT00798239 Phase 1, Phase 2
42 Pilot Study to Assess Safety/Preliminary Effectiveness of Prefix in Subjects With Degenerative Disc Disease (DDD) Undergoing Spine Fusion Surgery Unknown status NCT00798902 Phase 1, Phase 2
43 Efficiency and Safety Study of Pamidronate in Inflammatory Back Pain Due to Degenerative Disk Disease Unknown status NCT01799616 Phase 2 Pamidronate
44 Clinical Trial Based on the Use of Mesenchymal Stem Cells From Autologous Bone Marrow in Patients With Lumbar Intervertebral Degenerative Disc Disease Completed NCT01513694 Phase 1, Phase 2
45 Treatment of Degenerative Disc Disease With Allogenic Mesenchymal Stem Cells (MSV) Completed NCT01860417 Phase 1, Phase 2 Mepivacaine
46 Study to Evaluate the Safety and Preliminary Efficacy of IDCT, a Treatment for Symptomatic Lumbar Intervertebral Disc Degeneration Recruiting NCT03347708 Phase 1, Phase 2 Saline Solution;Sodium Hyaluronate
47 Effect of Abaloparatide on Lumbar Disc Degeneration Not yet recruiting NCT03708926 Phase 2 Abaloparatide;Placebo
48 A Clinical Trial to Evaluate the Safety, Tolerability and Preliminary Effectiveness of Single Administration Intradiscal rhGDF-5 for the Treatment of Early Stage Lumbar Disc Degeneration Completed NCT01158924 Phase 1, Phase 2 Intradiscal rhGDF-5
49 A Clinical Trial to Evaluate the Safety, Tolerability and Preliminary Effectiveness of Single Administration Intradiscal rhGDF-5 for the Treatment of Early Stage Lumbar Disc Degeneration Completed NCT01182337 Phase 1, Phase 2 Intradiscal rhGDF-5;Vehicle control
50 Safety, Tolerability and Efficacy of YH14618 in Patients With Degenerative Disc Disease Completed NCT01526330 Phase 1, Phase 2 YH14618;YH14618;YH14618;Placebo

Search NIH Clinical Center for Intervertebral Disc Disease

Cochrane evidence based reviews: intervertebral disc degeneration

Sources

Genetic Tests for Intervertebral Disc Disease

About this section

Genetic tests related to Intervertebral Disc Disease:

# Genetic test Affiliating Genes
1 Intervertebral Disc Disorder 30 ASPN CILP COL11A1 COL9A3 THBS2
2 Abnormality of the Intervertebral Disk 30
Sources

Anatomical Context for Intervertebral Disc Disease

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MalaCards organs/tissues related to Intervertebral Disc Disease:

42
Bone, Bone Marrow, Spinal Cord, Testes, Endothelial, Pineal
Sources

Publications for Intervertebral Disc Disease

About this section

Articles related to Intervertebral Disc Disease:

(show top 50) (show all 665)
# Title Authors Year
1
The effect of body condition on postoperative recovery of dachshunds with intervertebral disc disease treated with postoperative physical rehabilitation. ( 30549081 )
2019
2
Osteoporosis therapies might lead to intervertebral disc degeneration via affecting cartilage endplate. ( 30902151 )
2019
3
LINC00641 regulates autophagy and intervertebral disc degeneration by acting as a competitive endogenous RNA of miR-153-3p under nutrition deprivation stress. ( 30378116 )
2019
4
Bone morphogenetic protein 2 alleviated intervertebral disc degeneration through mediating the degradation of ECM and apoptosis of nucleus pulposus cells via the PI3K/Akt pathway. ( 30387830 )
2019
5
IL-6/YAP1/β-catenin signaling is involved in intervertebral disc degeneration. ( 30511395 )
2019
6
Melatonin ameliorates intervertebral disc degeneration via the potential mechanisms of mitophagy induction and apoptosis inhibition. ( 30609271 )
2019
7
Influence of microgravity-induced intervertebral disc degeneration of rats on expression levels of p53/p16 and proinflammatory factors. ( 30680015 )
2019
8
Assessment of changes in the micro-nano environment of intervertebral disc degeneration based on Pfirrmann grade. ( 30710732 )
2019
9
ISSLS Prize in Basic science 2019: Physical activity attenuates fibrotic alterations to the multifidus muscle associated with intervertebral disc degeneration. ( 30737621 )
2019
10
Ligustilide alleviated IL-1β induced apoptosis and extracellular matrix degradation of nucleus pulposus cells and attenuates intervertebral disc degeneration in vivo. ( 30785069 )
2019
11
miR-486-5p Inhibits Inflammatory Response, Matrix Degradation and Apoptosis of Nucleus Pulposus Cells through Directly Targeting FOXO1 in Intervertebral Disc Degeneration. ( 30790508 )
2019
12
ERRFI1 Inhibits Proliferation and Inflammation of Nucleus Pulposus and is Negatively Regulated by miR-2355-5p in Intervertebral Disc Degeneration. ( 30817728 )
2019
13
Upregulated miR-154 promotes ECM degradation in intervertebral disc degeneration. ( 30825225 )
2019
14
TGF-β Initiates β-Catenin-Mediated CTGF Secretory Pathway in Old Bovine Nucleus Pulposus Cells: A Potential Mechanism for Intervertebral Disc Degeneration. ( 30828686 )
2019
15
Behavioral Compensations and Neuronal Remodeling in a Rodent Model of Chronic Intervertebral Disc Degeneration. ( 30842475 )
2019
16
Effect of needle diameter, type and volume of contrast agent on intervertebral disc degeneration in rats with discography. ( 30864063 )
2019
17
Multifidus Muscles Lipid Content Is Associated with Intervertebral Disc Degeneration: A Quantitative Magnetic Resonance Imaging Study. ( 30866613 )
2019
18
Application of Finite Element Analysis for Investigation of Intervertebral Disc Degeneration: from Laboratory to Clinic. ( 30868485 )
2019
19
A new understanding of the role of IL-1 in age-related intervertebral disc degeneration in a murine model. ( 30875127 )
2019
20
Systemic clearance of p16INK4a -positive senescent cells mitigates age-associated intervertebral disc degeneration. ( 30900385 )
2019
21
MicroRNA Expression Profiles, Target Genes and Pathways in Intervertebral Disc Degeneration; A Meta-analysis of Three Microarray Studies. ( 30904808 )
2019
22
Ventral Slot Surgery to Manage Cervical Intervertebral Disc Disease in Three Cats. ( 29325196 )
2018
23
Canine pancreatic lipase immunoreactivity concentrations associated with intervertebral disc disease in 84 dogs. ( 29355958 )
2018
24
Intervertebral Disc Degeneration During Postoperative Follow-up More Than 10 Years After Corrective Surgery in Idiopathic Scoliosis: Comparison Between Patients With and Without Surgery. ( 28678107 )
2018
25
Effects of interleukin-17A in nucleus pulposus cells and its small-molecule inhibitors for intervertebral disc disease. ( 30207057 )
2018
26
Osteoporosis of the vertebra and osteochondral remodeling of the endplate causes intervertebral disc degeneration in ovariectomized mice. ( 30201052 )
2018
27
Leptin and the intervertebral disc: a biochemical link exists between obesity, intervertebral disc degeneration and low back pain-an in vitro study in a bovine model. ( 30324498 )
2018
28
Transplantation of Hypoxic-Preconditioned Bone Mesenchymal Stem Cells Retards Intervertebral Disc Degeneration via Enhancing Implanted Cell Survival and Migration in Rats. ( 29535780 )
2018
29
Dysregulated MiR-3150a-3p Promotes Lumbar Intervertebral Disc Degeneration by Targeting Aggrecan. ( 29554650 )
2018
30
Understanding the molecular biology of intervertebral disc degeneration and potential gene therapy strategies for regeneration: a review. ( 29567950 )
2018
31
Novel stepwise model of intervertebral disc degeneration with intact annulus fibrosus to test regeneration strategies. ( 29603340 )
2018
32
A novel mouse model of intervertebral disc degeneration shows altered cell fate and matrix homeostasis. ( 29605718 )
2018
33
Association of IL10 and TGFB single nucleotide polymorphisms with intervertebral disc degeneration in Iranian population: a case control study. ( 29636026 )
2018
34
Quantitative magnetic resonance imaging for diagnosis of intervertebral disc degeneration of the cervico-thoracic junction: a pilot study. ( 29636882 )
2018
35
Circular RNA circ-4099 is induced by TNF-α and regulates ECM synthesis by blocking miR-616-5p inhibition of Sox9 in intervertebral disc degeneration. ( 29651107 )
2018
36
Meta-Analysis of the Association Between FAS Ligand and TRAIL Genetic Polymorphisms and Intervertebral Disc Degeneration Susceptibility in Chinese Han population. ( 29652777 )
2018
37
Wnt5a suppresses inflammation-driven intervertebral disc degeneration via a TNF-α/NF-κB-Wnt5a negative-feedback loop. ( 29656141 )
2018
38
Apparent Diffusion Coefficient of Diffusion-Weighted Imaging in Evaluation of Cervical Intervertebral Disc Degeneration: An Observational Study with 3.0 T Magnetic Resonance Imaging. ( 29670903 )
2018
39
The Role of Adipokines in Intervertebral Disc Degeneration. ( 29695079 )
2018
40
Silencing SUMO2 promotes protection against degradation and apoptosis of nucleus pulposus cells through p53 signaling pathway in intervertebral disc degeneration. ( 29700214 )
2018
41
Evaluation of Lumbar Intervertebral Disc Degeneration Using T1ρ and T2 Magnetic Resonance Imaging in a Rabbit Disc Injury Model. ( 29713414 )
2018
42
A novel in vivo porcine model of intervertebral disc degeneration induced by cryoinjury. ( 29744650 )
2018
43
A Qualitative and Quantitative Correlation Study of Lumbar Intervertebral Disc Degeneration Using Glycosaminoglycan Chemical Exchange Saturation Transfer, Pfirrmann Grade, and T1-ρ. ( 29748204 )
2018
44
microRNA-665 promotes the proliferation and matrix degradation of nucleus pulposus through targeting GDF5 in intervertebral disc degeneration. ( 29761869 )
2018
45
Current insights on use of growth factors as therapy for Intervertebral Disc Degeneration. ( 29779014 )
2018
46
Endplate Defect Is Heritable, Associated With Low Back Pain and Triggers Intervertebral Disc Degeneration: A Longitudinal Study From TwinsUK. ( 29847371 )
2018
47
Association of interleukin 1 gene polymorphism with intervertebral disc degeneration risk in the Chinese Han population. ( 29884765 )
2018
48
Experimental research on the effect of microRNA-21 inhibitor on a rat model of intervertebral disc degeneration. ( 29896228 )
2018
49
Comprehensive evaluation of differential lncRNA and gene expression in patients with intervertebral disc degeneration. ( 29901136 )
2018
50
Autophagy attenuates compression-induced apoptosis of human nucleus pulposus cells via MEK/ERK/NRF1/Atg7 signaling pathways during intervertebral disc degeneration. ( 29908161 )
2018
Sources

Variations for Intervertebral Disc Disease

About this section

UniProtKB/Swiss-Prot genetic disease variations for Intervertebral Disc Disease:

76
# Symbol AA change Variation ID SNP ID
1 COL9A2 p.Gln326Trp VAR_012658 rs137853213

ClinVar genetic disease variations for Intervertebral Disc Disease:

6 (show all 14)
# Gene Variation Type Significance SNP ID Assembly Location
1 ASPN NM_017680.4(ASPN): c.112_114GAT[14] (p.Asp50_Glu51insAsp) NT expansion risk factor GRCh37 Chromosome 9, 95237030: 95237032
2 ASPN NM_017680.4(ASPN): c.112_114GAT[14] (p.Asp50_Glu51insAsp) NT expansion risk factor GRCh38 Chromosome 9, 92474748: 92474750
3 CILP NM_003613.3(CILP): c.1184T> C (p.Ile395Thr) single nucleotide variant risk factor rs2073711 GRCh37 Chromosome 15, 65494212: 65494212
4 CILP NM_003613.3(CILP): c.1184T> C (p.Ile395Thr) single nucleotide variant risk factor rs2073711 GRCh38 Chromosome 15, 65201874: 65201874
5 THBS2 NM_003247.3(THBS2): c.1478-8C> T single nucleotide variant risk factor rs9406328 GRCh38 Chromosome 6, 169234915: 169234915
6 THBS2 NM_003247.3(THBS2): c.1478-8C> T single nucleotide variant risk factor rs9406328 GRCh37 Chromosome 6, 169635010: 169635010
7 COL9A3 NM_001853.4(COL9A3): c.307C> T (p.Arg103Trp) single nucleotide variant risk factor rs61734651 GRCh37 Chromosome 20, 61451332: 61451332
8 COL9A3 NM_001853.4(COL9A3): c.307C> T (p.Arg103Trp) single nucleotide variant risk factor rs61734651 GRCh38 Chromosome 20, 62819980: 62819980
9 COL11A1 NM_001854.3(COL11A1): c.4603T> C (p.Ser1535Pro) single nucleotide variant Benign rs1676486 GRCh37 Chromosome 1, 103354138: 103354138
10 COL11A1 NM_001854.3(COL11A1): c.4603T> C (p.Ser1535Pro) single nucleotide variant Benign rs1676486 GRCh38 Chromosome 1, 102888582: 102888582
11 COL9A2 NM_001852.3(COL9A2): c.976_977delCAinsTG (p.Gln326Trp) indel Benign rs137853213 GRCh37 Chromosome 1, 40773149: 40773150
12 COL9A2 NM_001852.3(COL9A2): c.976_977delCAinsTG (p.Gln326Trp) indel Benign rs137853213 GRCh38 Chromosome 1, 40307477: 40307478
13 COL9A2 NM_001852.3(COL9A2): c.2059A> G (p.Lys687Glu) single nucleotide variant Uncertain significance rs201847956 GRCh38 Chromosome 1, 40301193: 40301193
14 COL9A2 NM_001852.3(COL9A2): c.2059A> G (p.Lys687Glu) single nucleotide variant Uncertain significance rs201847956 GRCh37 Chromosome 1, 40766865: 40766865
Sources

Expression for Intervertebral Disc Disease

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Search GEO for disease gene expression data for Intervertebral Disc Disease.
Sources

Pathways for Intervertebral Disc Disease

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Pathways related to Intervertebral Disc Disease according to GeneCards Suite gene sharing:

(show all 47)
# Super pathways Score Top Affiliating Genes
1
Phospholipase-C Pathway 65
Show member pathways
 12.94 COL11A1 COL9A2 COL9A3 IL2 IL6
2
PI3K-Akt signaling pathway 38
Show member pathways
 12.86 COL9A2 COL9A3 IL2 IL6 THBS2
3
Collagen chain trimerization 67
Show member pathways
 12.72 COL11A1 COL9A2 COL9A3 MMP9
4
NF-KappaB Family Pathway 65
Show member pathways
 12.59 IL1A IL1B IL2 IL6
5
Degradation of the extracellular matrix 67
Show member pathways
 12.56 ASPN COL11A1 COL9A2 COL9A3 MMP9
6
Th17 cell differentiation 38
Show member pathways
 12.48 IL1A IL1B IL2 IL6
7
Influenza A 38
Show member pathways
 12.47 IL1A IL1B IL2 IL6
8
T cell receptor signaling pathway 38
Show member pathways
 12.29 IL1A IL1B IL2 IL6
9
Immune response IFN alpha/beta signaling pathway 23
Show member pathways
 12.15 IL1A IL1B IL2 IL6
10
IL-1 Family Signaling Pathways 66
Show member pathways
 12.11 IL1A IL1B IL6
11
C-type lectin receptor signaling pathway 38
Show member pathways
 12.1 IL1B IL2 IL6
12
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.07 IL1A IL1B IL6
13
Tuberculosis 38
12.05 IL1A IL1B IL6 VDR
14
ECM-receptor interaction 38
Show member pathways
 12.03 COL9A2 COL9A3 THBS2
15
Fluid shear stress and atherosclerosis 38
11.99 IL1A IL1B MMP9
16
G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins 23
Show member pathways
 11.98 COL11A1 COL9A2 COL9A3 IL1A IL1B MMP9
17
Immune response IFN gamma signaling pathway 23
Show member pathways
 11.97 IL1A IL1B IL2 IL6
18
Th1 Differentiation Pathway 66
Show member pathways
 11.96 IL1B IL2 IL6
19
Microglia Activation During Neuroinflammation: Overview 66
Show member pathways
 11.94 IL1B IL6 MMP9
20
MAPK Pathway 73
Show member pathways
 11.93 IL1A IL1B IL2
21
TNF signaling pathway 38
11.87 IL1B IL6 MMP9
22
Senescence and Autophagy in Cancer 1
11.85 IL1A IL1B IL6
23
AGE-RAGE signaling pathway in diabetic complications 38
11.81 IL1A IL1B IL6
24
Hematopoietic cell lineage 38
11.79 IL1A IL1B IL6
25
Interleukin-4 and 13 signaling 67
11.79 IL1A IL1B IL6 MMP9
26
Rheumatoid arthritis 38
11.75 IL1A IL1B IL6
27
Spinal Cord Injury 1
11.73 IL1A IL1B IL2 IL6 MMP9
28
Salmonella infection (KEGG) 38
11.72 IL1A IL1B IL6
29
Pertussis 38
11.66 IL1A IL1B IL6
30
Dendritic Cells Developmental Lineage Pathway 66
11.64 IL1B IL2 IL6
31
Lung fibrosis 1
11.55 IL1B IL6 MMP9
32
Microglia Activation During Neuroinflammation: Microglia Polarization 66
11.52 IL1B IL2 IL6 MMP9
33
ECM proteoglycans 67
11.5 ASPN COL9A2 COL9A3
34
Interleukin-10 signaling 67
11.42 IL1A IL1B IL6
35
Malaria 38
11.41 IL1B IL6 THBS2
36
Hematopoietic Stem Cell Differentiation 1
11.39 IL1A IL1B IL6
37
Transcription_Role of VDR in regulation of genes involved in osteoporosis 23
11.28 IL1A IL1B IL6 VDR
38
Development and heterogeneity of the ILC family 1
11.21 IL1B IL6
39
IL-10 Pathway 65
11.2 IL1A IL1B IL6
40
Antifolate resistance 38
11.19 IL1B IL6
41
Prion diseases 38
11.18 IL1A IL1B IL6
42
IL1 and megakaryocytes in obesity 1
11.09 IL1B MMP9
43
G-protein signaling_RhoB regulation pathway 23
11.06 IL1A IL1B IL2 IL6
44
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 10.82 IL1A IL1B IL2 IL6 MMP9
45
Cytokines and Inflammatory Response 1
10.72 IL1A IL1B IL2 IL6
46
G-protein signaling_Rap2B regulation pathway 23
10.6 COL11A1 COL9A2 COL9A3 IL1A IL1B IL2
47
Interleukin-1 processing 67
10.44 IL1A IL1B
Sources

GO Terms for Intervertebral Disc Disease

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Cellular components related to Intervertebral Disc Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum lumen GO:0005788 9.67 COL11A1 COL9A2 COL9A3 IL6
2 collagen-containing extracellular matrix GO:0062023 9.65 ASPN CILP COL11A1 MMP9 THBS2
3 extracellular space GO:0005615 9.65 CILP COL11A1 COL9A2 COL9A3 IL1A IL1B
4 extracellular matrix GO:0031012 9.63 ASPN COL11A1 COL9A2 COL9A3 MMP9 THBS2
5 collagen trimer GO:0005581 9.58 COL11A1 COL9A2 COL9A3
6 extracellular region GO:0005576 9.36 ASPN CILP COL11A1 COL9A2 COL9A3 IL1A
7 collagen type IX trimer GO:0005594 9.32 COL9A2 COL9A3

Biological processes related to Intervertebral Disc Disease according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.86 IL1A IL1B IL2 IL6
2 regulation of signaling receptor activity GO:0010469 9.84 IL1A IL1B IL2 IL6
3 negative regulation of cell proliferation GO:0008285 9.81 IL1A IL1B IL6 VDR
4 positive regulation of gene expression GO:0010628 9.8 IL1A IL1B IL6 VDR
5 positive regulation of protein phosphorylation GO:0001934 9.76 IL1B IL2 MMP9
6 skeletal system development GO:0001501 9.7 COL9A2 MMP9 VDR
7 endodermal cell differentiation GO:0035987 9.59 COL11A1 MMP9
8 positive regulation of mitotic nuclear division GO:0045840 9.58 IL1A IL1B
9 positive regulation of vascular endothelial growth factor production GO:0010575 9.57 IL1A IL1B
10 extracellular matrix organization GO:0030198 9.56 COL11A1 COL9A2 COL9A3 MMP9
11 negative regulation of neurogenesis GO:0050768 9.55 IL1B IL6
12 positive regulation of T cell proliferation GO:0042102 9.5 IL1B IL2 IL6
13 positive regulation of glial cell proliferation GO:0060252 9.48 IL1B IL6
14 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.46 IL1A IL1B
15 positive regulation of immunoglobulin secretion GO:0051024 9.43 IL2 IL6
16 ectopic germ cell programmed cell death GO:0035234 9.4 IL1A IL1B
17 positive regulation of neuroinflammatory response GO:0150078 9.37 IL1B IL6
18 fever generation GO:0001660 9.16 IL1A IL1B
19 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.13 IL1A IL1B IL2
20 cytokine-mediated signaling pathway GO:0019221 9.02 IL1A IL1B IL2 IL6 MMP9
21 positive regulation of transcription by RNA polymerase II GO:0045944 10 IL1A IL1B IL2 IL6 VDR

Molecular functions related to Intervertebral Disc Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.46 IL1A IL1B IL2 IL6
2 interleukin-1 receptor binding GO:0005149 9.26 IL1A IL1B
3 extracellular matrix structural constituent conferring tensile strength GO:0030020 9.13 COL11A1 COL9A2 COL9A3
4 extracellular matrix structural constituent GO:0005201 9.02 CILP COL11A1 COL9A2 COL9A3 THBS2
Sources

Sources for Intervertebral Disc Disease

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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