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IDD
MCID: INT146
MIFTS: 64

Intervertebral Disc Disease (IDD)

Categories: Bone diseases, Genetic diseases, Muscle diseases, Rare diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Intervertebral Disc Disease

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MalaCards integrated aliases for Intervertebral Disc Disease:

Name: Intervertebral Disc Disease 58 54 26 76 56 41
Intervertebral Disc Degeneration 54 26 45 74
Intervertebral Disc Disorder 26 30 6 74
Lumbar Disc Disease 58 76 56 74
Idd 58 54 26 76
Intervertebral Disc Disease, Susceptibility to 58 13 6
Lumbar Disc Degeneration 58 76 17
Lumbar Disc Herniation 58 76 17
Lumbar Disc Herniation, Susceptibility to 58 6
Lumbar Disc Disease, Susceptibility to 58 6
Intervertebral Disc Displacement 45 17
Lumbar Disc Degeneration, Susceptibility to 6
Degeneration of Lumbar Intervertebral Disc 74
Abnormality of the Intervertebral Disk 30
Intervertebral Disk Degeneration 26
Intervertebral Disk Displacement 74
Disorder of Intervertebral Disc 26
Intervertebral Disk Disease 76
Degenerative Disc Disease 54
Discogenic Disorder 26
Discogenic Disease 26
Ldd 76
Ldh 76

Classifications:

MalaCards categories:
Global: Genetic diseases Rare diseases
Anatomical: Bone diseases Muscle diseases
See all MalaCards categories (disease lists)
ICD10: 34


Sources

Summaries for Intervertebral Disc Disease

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NIH Rare Diseases : 54 Intervertebral disc disease (IDD) is a common musculoskeletal condition that primarily affects the back. It is characterized by intervertebral disc herniation and/or sciatic pain (sciatica) and is a primary cause of low back pain, affecting about 5% of individuals. Both environmental and genetic factors are thought to predispose an individual to developing the condition. Treatment for IDD may include physical therapy, pain medications, and sometimes surgical intervention such as discectomy or spinal fusion.

MalaCards based summary : Intervertebral Disc Disease, also known as intervertebral disc degeneration, is related to radiculopathy and osteoarthritis, and has symptoms including sciatica An important gene associated with Intervertebral Disc Disease is COL9A3 (Collagen Type IX Alpha 3 Chain), and among its related pathways/superpathways are Collagen chain trimerization and Degradation of the extracellular matrix. The drugs Dopamine and Norepinephrine have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and spinal cord, and related phenotypes are immune system and cardiovascular system

Genetics Home Reference : 26 Intervertebral disc disease is a common condition characterized by the breakdown (degeneration) of one or more of the discs that separate the bones of the spine (vertebrae), causing pain in the back or neck and frequently in the legs and arms. The intervertebral discs provide cushioning between vertebrae and absorb pressure put on the spine.

OMIM : 58 Lumbar disc disease is caused by degeneration of intervertebral discs of the lumbar spine. One of the most common musculoskeletal disorders, it has strong genetic determinants (Matsui et al., 1998; Battie et al., 1995; Sambrook et al., 1999). (603932)

UniProtKB/Swiss-Prot : 76 Intervertebral disc disease: A common musculo-skeletal disorder caused by degeneration of intervertebral disks of the lumbar spine. It results in low-back pain and unilateral leg pain.

Sources

Related Diseases for Intervertebral Disc Disease

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Diseases related to Intervertebral Disc Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 371)
# Related Disease Score Top Affiliating Genes
1 radiculopathy 30.8 IL1A IL6
2 osteoarthritis 30.1 ASPN CILP IL1B IL6
3 degenerative disc disease 30.1 ASPN COL9A3 VDR
4 spondylosis 30.0 IL1B VDR
5 demyelinating disease 29.6 IFNG IL1B MMP9
6 prostatitis 29.4 IL1B IL6 VDR
7 typhoid fever 29.3 IFNG IL1B IL6
8 osteomyelitis 29.1 IFNG IL1A IL1B IL6
9 meningitis 28.9 IFNG IL1B IL6 MMP9
10 arthritis 28.9 IFNG IL1A IL1B IL6 MMP9
11 rheumatoid arthritis 28.9 IFNG IL1A IL1B IL6 MMP9
12 asthma 28.8 IFNG IL1A IL1B IL6 MMP9
13 osteoporosis 28.5 IFNG IL1A IL1B IL6 VDR
14 lactate dehydrogenase b deficiency 12.0
15 cowden syndrome 1 11.8
16 lactate dehydrogenase deficiency 11.8
17 spondyloepiphyseal dysplasia with congenital joint dislocations 11.3
18 loeys-dietz syndrome 3 11.3
19 short stature and advanced bone age, with or without early-onset osteoarthritis and/or osteochondritis dissecans 11.3
20 follicular lymphoma 11.1
21 testicular seminoma 11.1
22 fanconi-bickel syndrome 11.1
23 glycogen storage disease due to lactate dehydrogenase deficiency 11.1
24 cauda equina syndrome 10.7
25 spinal stenosis 10.5
26 multiple epiphyseal dysplasia due to collagen 9 anomaly 10.4 COL9A2 COL9A3
27 epiphyseal dysplasia, multiple, 2 10.4 COL9A2 COL9A3
28 epiphyseal dysplasia, multiple, 3 10.4 COL9A2 COL9A3
29 epiphyseal dysplasia, multiple, 4 10.4 COL9A2 COL9A3
30 epiphyseal dysplasia, multiple, 5 10.4 COL9A2 COL9A3
31 global developmental delay, absent or hypoplastic corpus callosum, and dysmorphic facies 10.4
32 pain - chronic 10.3
33 bone mineral density quantitative trait locus 8 10.3
34 bone mineral density quantitative trait locus 15 10.3
35 diabetic foot ulcers 10.3 IL6 MMP9
36 acute transverse myelitis 10.3 IL6 MMP9
37 transverse myelitis 10.3 IL6 MMP9
38 vitreoretinal degeneration 10.2 COL11A1 COL9A2
39 recurrent corneal erosion 10.2 IL1B IL6
40 alkaptonuria 10.2
41 bagassosis 10.2 IL1B IL6
42 diabetes mellitus 10.2
43 depression 10.2
44 periodontitis, chronic 10.2 IL1B IL6
45 pneumococcal meningitis 10.2 COL11A1 MMP9
46 uremic pruritus 10.2 IL1B IL6
47 glossitis 10.2 IL1B IL6
48 melanoma 10.2
49 photokeratitis 10.2 IL6 MMP9
50 laryngitis 10.2 IL1B IL6

Comorbidity relations with Intervertebral Disc Disease via Phenotypic Disease Network (PDN):


Acute Cystitis Bronchitis
Chronic Myocardial Ischemia Deficiency Anemia
Esophagitis Heart Disease
Hypertension, Essential Ischemic Heart Disease
Osteoporosis

Graphical network of the top 20 diseases related to Intervertebral Disc Disease:



Diseases related to Intervertebral Disc Disease
Sources

Symptoms & Phenotypes for Intervertebral Disc Disease

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Clinical features from OMIM:

603932

UMLS symptoms related to Intervertebral Disc Disease:


sciatica

MGI Mouse Phenotypes related to Intervertebral Disc Disease:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.92 COL11A1 IFNG IL1A IL1B IL6 MMP9
2 cardiovascular system MP:0005385 9.91 IFNG IL1A IL1B IL6 MMP9 THBS2
3 integument MP:0010771 9.8 IFNG IL1A IL1B IL6 MMP9 THBS2
4 limbs/digits/tail MP:0005371 9.55 COL11A1 COL9A2 MMP9 THBS2 VDR
5 neoplasm MP:0002006 9.43 IFNG IL1A IL1B IL6 MMP9 THBS2
6 skeleton MP:0005390 9.23 COL11A1 COL9A2 IFNG IL1B IL6 MMP9
Sources

Drugs & Therapeutics for Intervertebral Disc Disease

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Drugs for Intervertebral Disc Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 168)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 4 62-31-7, 51-61-6 681
2
Norepinephrine Approved Phase 4 51-41-2 439260
3
Eplerenone Approved Phase 4 107724-20-9 443872 150310
4
Oxycodone Approved, Illicit, Investigational Phase 4,Not Applicable 76-42-6 5284603
5
Morphine Approved, Investigational Phase 4,Phase 3,Not Applicable 57-27-2 5288826
6
Bupivacaine Approved, Investigational Phase 4,Not Applicable,Early Phase 1 38396-39-3, 2180-92-9 2474
7 Serotonin and Noradrenaline Reuptake Inhibitors Phase 4
8 Neurotransmitter Uptake Inhibitors Phase 4
9 Antidepressive Agents Phase 4
10 Neurotransmitter Agents Phase 4,Phase 3,Not Applicable
11 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
12 Analgesics Phase 4,Phase 3,Not Applicable
13 Psychotropic Drugs Phase 4,Not Applicable
14 Dopamine Agents Phase 4
15 Duloxetine Hydrochloride Phase 4
16
s 1 (combination) Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
17 Hormones Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
18 Diuretics, Potassium Sparing Phase 4,Phase 3,Phase 2,Not Applicable
19 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Not Applicable,Early Phase 1
20 Hormone Antagonists Phase 4,Phase 3,Not Applicable,Early Phase 1
21 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
22 Anesthetics, Local Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
23 Anesthetics Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
24 Pharmaceutical Solutions Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
25 Mineralocorticoids Phase 4
26 Natriuretic Agents Phase 4
27 Antihypertensive Agents Phase 4,Not Applicable
28 diuretics Phase 4
29 Mineralocorticoid Receptor Antagonists Phase 4
30 Narcotics Phase 4,Phase 3,Not Applicable
31 Analgesics, Opioid Phase 4,Phase 3,Not Applicable
32
Serotonin Investigational, Nutraceutical Phase 4,Not Applicable 50-67-9 5202
33
Methylprednisolone hemisuccinate Approved Phase 3,Not Applicable,Early Phase 1 2921-57-5
34
Methylprednisolone Approved, Vet_approved Phase 3,Not Applicable,Early Phase 1 83-43-2 6741
35
Prednisolone Approved, Vet_approved Phase 3,Not Applicable,Early Phase 1 50-24-8 5755
36
Lidocaine Approved, Vet_approved Phase 3,Phase 2,Not Applicable,Early Phase 1 137-58-6 3676
37
Prednisolone phosphate Approved, Vet_approved Phase 3,Not Applicable,Early Phase 1 302-25-0
38
Hyaluronic acid Approved, Vet_approved Phase 3,Phase 1,Phase 2 9004-61-9 53477741
39
Benzocaine Approved, Investigational Phase 3,Not Applicable 1994-09-7, 94-09-7 2337
40
tannic acid Approved Phase 3,Not Applicable 1401-55-4
41
Ropivacaine Approved Phase 3 84057-95-4 175805 71273
42
Racepinephrine Approved Phase 3 329-65-7 838
43
Epinephrine Approved, Vet_approved Phase 3 51-43-4 5816
44
Infliximab Approved Phase 3 170277-31-3
45
Tramadol Approved, Investigational Phase 3,Not Applicable 27203-92-5 33741
46
Buprenorphine Approved, Illicit, Investigational, Vet_approved Phase 3 52485-79-7 644073 40400
47
Calcium Approved, Nutraceutical Phase 3,Phase 1,Phase 2,Not Applicable 7440-70-2 271
48
Prednisolone hemisuccinate Experimental Phase 3,Not Applicable,Early Phase 1 2920-86-7
49 Protective Agents Phase 3,Phase 1,Phase 2,Not Applicable,Early Phase 1
50 Anti-Arrhythmia Agents Phase 3,Phase 2,Not Applicable

Interventional clinical trials:

(show top 50) (show all 346)
# Name Status NCT ID Phase Drugs
1 Duloxetine as an Analgesic Agent in Patients Undergoing Elective Spine Surgery Unknown status NCT02535000 Phase 4 Duloxetine;Placebo
2 A Prospective Study of the InterFuse T(tm), Unknown status NCT02678130 Phase 4
3 Study to Investigate the Performance of Cervical Arthroplasty for the Treatment of Cervical Degenerative Disc Disease Terminated NCT00700739 Phase 4
4 Efficacy and Safety of Expandable Spacer in the Treatment of Degenerative Disc Disease Using the Minimally Invasive Transforaminal Lumbar Interbody Fusion Surgical Approach Completed NCT02075554 Phase 4
5 Comparison of IDD Therapy and Non-surgical Treatment for Low Back Pain Caused by Degenerative Disc Disease Completed NCT00165893 Phase 4
6 Post-Market Surveillance Study of the TM Ardis Interbody Fusion System Completed NCT02429908 Phase 4
7 Eplerenone as a Supplement to Epidural Steroid Injections Recruiting NCT03418649 Phase 4 Eplerenone 50 Mg Tab;Placebo Oral Tablet
8 NanoFUSE® PL Gutter PMCF Not yet recruiting NCT03751943 Phase 4
9 Evaluation of Fusion Rate of Anterior Cervical Discectomy and Fusion (ACDF) Using Cervios ChronOs™ and Bonion™ Completed NCT01615328 Phase 4
10 Study Of Disc Anaesthesia For The Preoperative Diagnosis Of Chronic Lower Back Pain Completed NCT00443781 Phase 4
11 BIO4 Clinical Case Study: Cervical Spine Active, not recruiting NCT03077204 Phase 4
12 Efficacy of Using Solum IV and BMC With GFC in TLIF Withdrawn NCT03223701 Phase 4
13 Opioid Treatment for Chronic Low Back Pain and the Impact of Mood Symptoms Completed NCT01502644 Phase 4 Oxycodone;Morphine;Placebo
14 Caudal Epidural Steroid Injections for Low Back Pain/Sciatic Lumbar Pain Completed NCT01407913 Phase 4
15 A Prospective Study to Compare Bupivacaine and Exparel Versus Bupivacaine or Exparel Alone for Postoperative Pain Relief Recruiting NCT03514277 Phase 4 Exparel;Bupivacaine
16 Wallis Stabilization System for Low Back Pain Unknown status NCT00484458 Phase 3
17 Wallis Mechanical Normalization System for Low Back Pain Unknown status NCT00134537 Phase 3
18 Assessment of the Efficacy of an Intradiscal Injection of Corticoids in Modic I Discopathies. Unknown status NCT01694134 Phase 3 Hydrocortancyl.;Lidocaine
19 A Study of SI-6603 in Patients With Lumbar Disc Herniation Completed NCT02421601 Phase 3 Condoliase
20 A Study of SI-6603 in Patients With Lumbar Disc Herniation Completed NCT01941563 Phase 3 Condoliase;placebo
21 XL TDR® eXtreme Lateral Total Disc Replacement for the Treatment of Lumbar Degenerative Disc Disease (DDD) Completed NCT00927238 Phase 3
22 rhBMP-2/CRM/CD HORIZON® Spinal System Pivotal Study Completed NCT00707265 Phase 3
23 CHARITÉ™ Artificial Disc Compared to Anterior Interbody Fusion for Treatment of Degenerative Disc Disease Completed NCT00215306 Phase 3
24 Safety and Efficacy Study of Healos as a Bone Replacement to Treat Degenerative Disc Disease Completed NCT00316121 Phase 3
25 Efficacy of Intradiscal Injection of BM-MSC in Subjects With Chronic Low Back Pain (LBP) Due to Lumbar Degenerative Disc Disease (DDD) Unresponsive Recruiting NCT03737461 Phase 2, Phase 3 Allogenic BM-MSCs Injection
26 Titanium Surgical Mesh and MOSS-Miami Screws for Lumbar Fusion. Completed NCT00215319 Phase 3
27 MAVERICK™ Total Disc Replacement- Pivotal Study Completed NCT00635843 Phase 3
28 Cervical I/F Cage for Anterior Cervical Fusion Completed NCT00215293 Phase 3
29 Study of Safety & Effectiveness of PRESTIGE® LP Cervical Disc vs. Anterior Cervical Fusion in Cervical DDD Completed NCT00667459 Phase 3
30 Placebo-controlled Study to Evaluate Rexlemestrocel-L Alone or Combined With Hyaluronic Acid in Subjects With Chronic Low Back Pain Active, not recruiting NCT02412735 Phase 3 rexlemestrocel-L;rexlemestrocel-L + HA;Placebo
31 Prospective, Multi-center Study to Assess Posterolateral Fusion Using FIBERGRAFT Enrolling by invitation NCT03884283 Phase 3
32 Peri-Incisional Drug Injection in Lumbar Spine Surgery Recruiting NCT03513445 Phase 3 Morphine;Epinephrine;naropin
33 BackToBasic: Infliximab in Chronic Low Back Pain and Modic Changes Recruiting NCT03704363 Phase 3 Biosimilar Infliximab
34 Treatment of Symptomatic Lumbar Internal Disc Disruption (IDD) With the Biostat® System Terminated NCT01011816 Phase 3 Saline
35 Wallis Interspinous Dynamic Stability System for Lumbar Disc Herniation: a Prospective Study Completed NCT01824108 Phase 3
36 Impact of Local Steroid Application in Extreme Lateral Lumbar Interbody Fusion Recruiting NCT03327272 Phase 3 Methylprednisolone;Saline
37 Performance of the Hedrocel(R) Cervical Fusion Device Completed NCT00758758 Phase 3
38 Evaluation of Outcomes With Amniotic Fluid for Musculoskeletal Conditions Musculoskeletal Conditions Recruiting NCT03390920 Phase 2, Phase 3
39 NORSPAN Transdermal Patches Phase III Study In Non-Cancer Pain Completed NCT01476774 Phase 3 Buprenorphine Transdermal System;Buprenorphine Transdermal System
40 Pilot Study to Assess Safety/Prelimary Effectiveness of Prefix in Subjects With Degenerative Disc Disease (DDD) Undergoing Spine Fusion Surgery Unknown status NCT00798239 Phase 1, Phase 2
41 Pilot Study to Assess Safety/Preliminary Effectiveness of Prefix in Subjects With Degenerative Disc Disease (DDD) Undergoing Spine Fusion Surgery Unknown status NCT00798902 Phase 1, Phase 2
42 Efficiency and Safety Study of Pamidronate in Inflammatory Back Pain Due to Degenerative Disk Disease Unknown status NCT01799616 Phase 2 Pamidronate
43 Clinical Trial Based on the Use of Mesenchymal Stem Cells From Autologous Bone Marrow in Patients With Lumbar Intervertebral Degenerative Disc Disease Completed NCT01513694 Phase 1, Phase 2
44 Treatment of Degenerative Disc Disease With Allogenic Mesenchymal Stem Cells (MSV) Completed NCT01860417 Phase 1, Phase 2 Mepivacaine
45 Study to Evaluate the Safety and Preliminary Efficacy of IDCT, a Treatment for Symptomatic Lumbar Intervertebral Disc Degeneration Recruiting NCT03347708 Phase 1, Phase 2 Saline Solution;Sodium Hyaluronate
46 Effect of Abaloparatide on Lumbar Disc Degeneration Not yet recruiting NCT03708926 Phase 2 Abaloparatide;Placebo
47 Study to Evaluate the Safety and Preliminary Efficacy of IDCT, a Treatment for Symptomatic Lumbar Disc Degeneration Not yet recruiting NCT03955315 Phase 1, Phase 2
48 A Clinical Trial to Evaluate the Safety, Tolerability and Preliminary Effectiveness of Single Administration Intradiscal rhGDF-5 for the Treatment of Early Stage Lumbar Disc Degeneration Completed NCT01158924 Phase 1, Phase 2 Intradiscal rhGDF-5
49 A Clinical Trial to Evaluate the Safety, Tolerability and Preliminary Effectiveness of Single Administration Intradiscal rhGDF-5 for the Treatment of Early Stage Lumbar Disc Degeneration Completed NCT01182337 Phase 1, Phase 2 Intradiscal rhGDF-5;Vehicle control
50 Safety, Tolerability and Efficacy of YH14618 in Patients With Degenerative Disc Disease Completed NCT01526330 Phase 1, Phase 2 YH14618;YH14618;YH14618;Placebo

Search NIH Clinical Center for Intervertebral Disc Disease

Cochrane evidence based reviews: intervertebral disc degeneration

Sources

Genetic Tests for Intervertebral Disc Disease

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Genetic tests related to Intervertebral Disc Disease:

# Genetic test Affiliating Genes
1 Intervertebral Disc Disorder 30 ASPN CILP COL11A1 COL9A3 THBS2
2 Abnormality of the Intervertebral Disk 30
Sources

Anatomical Context for Intervertebral Disc Disease

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MalaCards organs/tissues related to Intervertebral Disc Disease:

42
Bone, Bone Marrow, Spinal Cord, B Cells, Brain, Liver, Heart
Sources

Publications for Intervertebral Disc Disease

About this section

Articles related to Intervertebral Disc Disease:

(show top 50) (show all 192)
# Title Authors Year
1
The Long-Term Reoperation Rate Following Surgery for Lumbar Herniated Intervertebral Disc Disease: A Nationwide Sample Cohort Study with A 10-Year Follow-Up. ( 30973508 )
2019
2
How best to support individuals with IDD as they become frail: Development of a consensus statement. ( 29947461 )
2019
3
Health beliefs and behaviours of families towards the health needs of children with intellectual and developmental disabilities (IDD) in Accra, Ghana. ( 30168225 )
2019
4
Understanding Decision Making Among Individuals With Intellectual and Developmental Disabilities (IDD) and Their Siblings. ( 30716002 )
2019
5
Fiscal Stewardship, Choice, and Control: The Context of Self-Directed Services for People With Intellectual and Developmental Disabilities (IDD) in the United States. ( 30920908 )
2019
6
Predictors of Emergency Room and Hospital Utilization Among Adults With Intellectual and Developmental Disabilities (IDD). ( 30920909 )
2019
7
Comparative genomic analysis of the IDD genes in five Rosaceae species and expression analysis in Chinese white pear (Pyrus bretschneideri). ( 30941270 )
2019
8
Increased Volume of Lumbar Surgeries for Herniated Intervertebral Disc Disease and Cost-Effectiveness Analysis: A Nationwide Cohort Study. ( 29095409 )
2018
9
Ventral Slot Surgery to Manage Cervical Intervertebral Disc Disease in Three Cats. ( 29325196 )
2018
10
Canine pancreatic lipase immunoreactivity concentrations associated with intervertebral disc disease in 84 dogs. ( 29355958 )
2018
11
Effects of interleukin-17A in nucleus pulposus cells and its small-molecule inhibitors for intervertebral disc disease. ( 30207057 )
2018
12
The effect of body condition on postoperative recovery of dachshunds with intervertebral disc disease treated with postoperative physical rehabilitation. ( 30549081 )
2018
13
The transition to adulthood of young adults with IDD: Parents' joint projects. ( 28834118 )
2018
14
Making Roots, Shoots, and Seeds: IDD Gene Family Diversification in Plants. ( 29056440 )
2018
15
IDD: what does it mean for dental practices and their patients? ( 30361606 )
2018
16
Improving Prediction of Risk of Admission to Long-Term Care or Mortality Among Home Care Users With IDD. ( 30595781 )
2018
17
Prevalence and breed predisposition for thoracolumbar intervertebral disc disease in cats. ( 26868632 )
2017
18
The efficacy of interlaminar epidural steroid administration in multilevel intervertebral disc disease with chronic low back pain: a randomized, blinded, prospective study. ( 27555486 )
2017
19
Correlation of matrix metalloproteinase (MMP)-1, -2, -3, and -9 expressions with demographic and radiological features in primary lumbar intervertebral disc disease. ( 28343922 )
2017
20
Bone Marrow-Derived Mesenchymal Stem Cells as Autologous Therapy in Dogs with Naturally Occurring Intervertebral Disc Disease: Feasibility, Safety, and Preliminary Results. ( 28471303 )
2017
21
Asthma and early herniated intervertebral disc disease. ( 28498027 )
2017
22
Retraction Notice: Lack of Relationship Between Occupational Workload and Microscopic Alterations in Lumbar Intervertebral Disc Disease. ( 28932331 )
2017
23
FGF4 retrogene on CFA12 is responsible for chondrodystrophy and intervertebral disc disease in dogs. ( 29073074 )
2017
24
Validation of the Choking Risk Assessment and Pneumonia Risk Assessment for adults with Intellectual and Developmental Disability (IDD). ( 28822297 )
2017
25
Elevated systemic glutamic acid level in the non-obese diabetic mouse is Idd linked and induces beta cell apoptosis. ( 27649685 )
2017
26
Structure of the SHR-SCR heterodimer bound to the BIRD/IDD transcriptional factor JKD. ( 28211915 )
2017
27
Phylogenetic analysis of IDD gene family and characterization of its expression in response to flower induction in Malus. ( 28314937 )
2017
28
Assessing the status of iodine deficiency disorder (IDD) and associated factors in Wolaita and Dawro Zones School Adolescents, southern Ethiopia. ( 28420409 )
2017
29
Complex Regional Pain Syndrome Caused by Lumbar Herniated Intervertebral Disc Disease. ( 27454281 )
2016
30
Evaluation of the Association Between Matrix Metalloproteinase 11 and Intervertebral Disc Disease. ( 26956825 )
2016
31
ICD-10: Intervertebral Disc Disease. ( 27514110 )
2016
32
DachsLife 2015: an investigation of lifestyle associations with the risk of intervertebral disc disease in Dachshunds. ( 27826450 )
2016
33
Genetic Alterations in Intervertebral Disc Disease. ( 27917384 )
2016
34
Association between COL9A2 Gln326Arg mutations and the development of intervertebral disc disease in a Chinese population. ( 28002589 )
2016
35
Development of a whole organ culture model for intervertebral disc disease. ( 30035069 )
2016
36
Parent Involvement in Meaningful Post-School Experiences for Young Adults With IDD and Pervasive Support Needs. ( 27494125 )
2016
37
Substance-related and addictive disorders among adults with intellectual and developmental disabilities (IDD): an Ontario population cohort study. ( 27591020 )
2016
38
More Job Services-Better Employment Outcomes: Increasing Job Attainment for People With IDD. ( 27893311 )
2016
39
Advancing the cellular and molecular therapy for intervertebral disc disease. ( 24993611 )
2015
40
Developments in intervertebral disc disease research: pathophysiology, mechanobiology, and therapeutics. ( 25694233 )
2015
41
Thoracolumbar partial lateral corpectomy for the treatment of chronic intervertebral disc disease in 107 dogs. ( 26629329 )
2015
42
Competency-Based Training and Worker Turnover in Community Supports for People With IDD: Results From a Group Randomized Controlled Study. ( 26107852 )
2015
43
Quality improvement project using a care bundle approach on the management of the immediate discharge document (IDD) within a single general practice. ( 26734324 )
2015
44
Neurologic outcome after thoracolumbar partial lateral corpectomy for intervertebral disc disease in 72 dogs. ( 24484371 )
2014
45
Lack of relationship between occupational workload and microscopic alterations in lumbar intervertebral disc disease. ( 25136392 )
2014
46
Intervertebral disc disease in Dachshunds radiographically screened for intervertebral disc calcifications. ( 25523328 )
2014
47
Factors that might impact intrathecal drug delivery (IDD) dose escalation: a longitudinal study. ( 23803173 )
2014
48
Radioisotope cisternography: a potentially useful tool for headache diagnosis in patients with an IDD pump. ( 24452661 )
2014
49
Direct support workforce supporting individuals with IDD: current wages, benefits, and stability. ( 25247725 )
2014
50
Intervertebral disc disease in dogs - part 1: a new histological grading scheme for classification of intervertebral disc degeneration in dogs. ( 22789628 )
2013
Sources

Variations for Intervertebral Disc Disease

About this section

UniProtKB/Swiss-Prot genetic disease variations for Intervertebral Disc Disease:

76
# Symbol AA change Variation ID SNP ID
1 COL9A2 p.Gln326Trp VAR_012658 rs137853213

ClinVar genetic disease variations for Intervertebral Disc Disease:

6 (show all 18)
# Gene Variation Type Significance SNP ID Assembly Location
1 ASPN NM_017680.4(ASPN): c.112_114GAT[14] (p.Asp50_Glu51insAsp) NT expansion risk factor GRCh37 Chromosome 9, 95237030: 95237032
2 ASPN NM_017680.4(ASPN): c.112_114GAT[14] (p.Asp50_Glu51insAsp) NT expansion risk factor GRCh38 Chromosome 9, 92474748: 92474750
3 CILP NM_003613.3(CILP): c.1184T> C (p.Ile395Thr) single nucleotide variant risk factor rs2073711 GRCh37 Chromosome 15, 65494212: 65494212
4 CILP NM_003613.3(CILP): c.1184T> C (p.Ile395Thr) single nucleotide variant risk factor rs2073711 GRCh38 Chromosome 15, 65201874: 65201874
5 THBS2 NM_003247.3(THBS2): c.1478-8C> T single nucleotide variant risk factor rs9406328 GRCh38 Chromosome 6, 169234915: 169234915
6 THBS2 NM_003247.3(THBS2): c.1478-8C> T single nucleotide variant risk factor rs9406328 GRCh37 Chromosome 6, 169635010: 169635010
7 COL11A1 NM_001854.3(COL11A1): c.4603T> C (p.Ser1535Pro) single nucleotide variant Benign rs1676486 GRCh37 Chromosome 1, 103354138: 103354138
8 COL11A1 NM_001854.3(COL11A1): c.4603T> C (p.Ser1535Pro) single nucleotide variant Benign rs1676486 GRCh38 Chromosome 1, 102888582: 102888582
9 COL9A3 NM_001853.4(COL9A3): c.307C> T (p.Arg103Trp) single nucleotide variant risk factor rs61734651 GRCh37 Chromosome 20, 61451332: 61451332
10 COL9A3 NM_001853.4(COL9A3): c.307C> T (p.Arg103Trp) single nucleotide variant risk factor rs61734651 GRCh38 Chromosome 20, 62819980: 62819980
11 COL9A2 NM_001852.3(COL9A2): c.976_977delCAinsTG (p.Gln326Trp) indel Benign rs137853213 GRCh37 Chromosome 1, 40773149: 40773150
12 COL9A2 NM_001852.3(COL9A2): c.976_977delCAinsTG (p.Gln326Trp) indel Benign rs137853213 GRCh38 Chromosome 1, 40307477: 40307478
13 COL9A3 NM_001853.4(COL9A3): c.388G> A (p.Gly130Ser) single nucleotide variant Uncertain significance rs139401633 GRCh37 Chromosome 20, 61453127: 61453127
14 COL9A3 NM_001853.4(COL9A3): c.388G> A (p.Gly130Ser) single nucleotide variant Uncertain significance rs139401633 GRCh38 Chromosome 20, 62821775: 62821775
15 COL9A3 NM_001853.4(COL9A3): c.505G> A (p.Ala169Thr) single nucleotide variant Uncertain significance rs948698664 GRCh37 Chromosome 20, 61453970: 61453970
16 COL9A3 NM_001853.4(COL9A3): c.505G> A (p.Ala169Thr) single nucleotide variant Uncertain significance rs948698664 GRCh38 Chromosome 20, 62822618: 62822618
17 COL9A2 NM_001852.3(COL9A2): c.2059A> G (p.Lys687Glu) single nucleotide variant Uncertain significance rs201847956 GRCh38 Chromosome 1, 40301193: 40301193
18 COL9A2 NM_001852.3(COL9A2): c.2059A> G (p.Lys687Glu) single nucleotide variant Uncertain significance rs201847956 GRCh37 Chromosome 1, 40766865: 40766865
Sources

Expression for Intervertebral Disc Disease

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Search GEO for disease gene expression data for Intervertebral Disc Disease.
Sources

Pathways for Intervertebral Disc Disease

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Pathways related to Intervertebral Disc Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 51)
# Super pathways Score Top Affiliating Genes
1
Collagen chain trimerization 67
Show member pathways
 12.73 COL11A1 COL9A2 COL9A3 MMP9
2
Degradation of the extracellular matrix 67
Show member pathways
 12.65 ASPN COL11A1 COL9A2 COL9A3 MMP9
3
Th17 cell differentiation 38
Show member pathways
 12.51 IFNG IL1A IL1B IL6
4
T cell receptor signaling pathway 38
Show member pathways
 12.48 IFNG IL1A IL1B IL6
5
IL-17 Family Signaling Pathways 66
Show member pathways
 12.25 IFNG IL1B IL6 MMP9
6
Toll Comparative Pathway 65
Show member pathways
 12.23 IFNG IL1A IL1B IL6
7
Immune response IFN alpha/beta signaling pathway 23
Show member pathways
 12.18 IFNG IL1A IL1B IL6
8
Toxoplasmosis 38
Show member pathways
 12.16 IFNG IL1A IL1B
9
IL-1 Family Signaling Pathways 66
Show member pathways
 12.12 IL1A IL1B IL6
10
Necroptosis 38
Show member pathways
 12.11 IFNG IL1A IL1B
11
Bacterial infections in CF airways 23
Show member pathways
 12.09 IFNG IL1B IL6
12
Colorectal Cancer Metastasis 65
12.09 IFNG IL6 MMP9
13
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.08 IL1A IL1B IL6
14
G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins 23
Show member pathways
 12.08 COL11A1 COL9A2 COL9A3 IL1A IL1B MMP9
15
ECM-receptor interaction 38
Show member pathways
 12.05 COL9A2 COL9A3 THBS2
16
Tuberculosis 38
12.02 IFNG IL1A IL1B IL6 VDR
17
Fluid shear stress and atherosclerosis 38
12 IFNG IL1A IL1B MMP9
18
Immune response IFN gamma signaling pathway 23
Show member pathways
 11.99 IFNG IL1A IL1B IL6
19
Th1 Differentiation Pathway 66
Show member pathways
 11.97 IFNG IL1B IL6
20
Osteoclast differentiation 38
11.96 IFNG IL1A IL1B
21
Microglia Activation During Neuroinflammation: Overview 66
Show member pathways
 11.95 IFNG IL1B IL6 MMP9
22
TNF signaling pathway 38
11.89 IL1B IL6 MMP9
23
Interleukin-4 and 13 signaling 67
11.88 IL1A IL1B IL6 MMP9
24
AGE-RAGE signaling pathway in diabetic complications 38
11.84 IL1A IL1B IL6
25
Senescence and Autophagy in Cancer 1
11.84 IFNG IL1A IL1B IL6
26
Hematopoietic cell lineage 38
11.82 IL1A IL1B IL6
27
Amoebiasis 38
11.81 IFNG IL1B IL6
28
Spinal Cord Injury 1
11.73 IFNG IL1A IL1B IL6 MMP9
29
Rheumatoid arthritis 38
11.72 IFNG IL1A IL1B IL6
30
Pertussis 38
11.71 IL1A IL1B IL6
31
Dendritic Cells Developmental Lineage Pathway 66
11.69 IFNG IL1B IL6
32
Salmonella infection (KEGG) 38
11.67 IFNG IL1A IL1B IL6
33
Lung fibrosis 1
11.6 IL1B IL6 MMP9
34
Microglia Activation During Neuroinflammation: Microglia Polarization 66
11.56 IFNG IL1B IL6 MMP9
35
ECM proteoglycans 67
11.55 ASPN COL9A2 COL9A3
36
Interleukin-10 signaling 67
11.48 IL1A IL1B IL6
37
Hematopoietic Stem Cell Differentiation 1
11.46 IL1A IL1B IL6
38
African trypanosomiasis 38
11.34 IFNG IL1B IL6
39
Malaria 38
11.31 IFNG IL1B IL6 THBS2
40
IL-10 Pathway 65
11.3 IL1A IL1B IL6
41
Prion diseases 38
11.3 IL1A IL1B IL6
42
Development and heterogeneity of the ILC family 1
11.25 IFNG IL1B IL6
43
Antifolate resistance 38
11.2 IL1B IL6
44
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.15 IFNG IL1A IL1B IL6 MMP9
45
G-protein signaling_RhoB regulation pathway 23
11.11 IL1A IL1B IL6
46
IL1 and megakaryocytes in obesity 1
11.11 IFNG IL1B MMP9
47
Hypertrophy Model 1
10.99 IFNG IL1A
48
Cytokines and Inflammatory Response 1
10.92 IFNG IL1A IL1B IL6
49
G-protein signaling_Rap2B regulation pathway 23
10.86 COL11A1 COL9A2 COL9A3 IL1A IL1B IL6
50
Transcription_Role of VDR in regulation of genes involved in osteoporosis 23
10.67 IFNG IL1A IL1B IL6 VDR
Sources

GO Terms for Intervertebral Disc Disease

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Cellular components related to Intervertebral Disc Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum lumen GO:0005788 9.67 COL11A1 COL9A2 COL9A3 IL6
2 collagen-containing extracellular matrix GO:0062023 9.65 ASPN CILP COL11A1 MMP9 THBS2
3 extracellular matrix GO:0031012 9.63 ASPN COL11A1 COL9A2 COL9A3 MMP9 THBS2
4 extracellular space GO:0005615 9.61 CILP COL11A1 COL9A2 COL9A3 IFNG IL1A
5 collagen trimer GO:0005581 9.58 COL11A1 COL9A2 COL9A3
6 extracellular region GO:0005576 9.36 ASPN CILP COL11A1 COL9A2 COL9A3 IFNG
7 collagen type IX trimer GO:0005594 9.32 COL9A2 COL9A3

Biological processes related to Intervertebral Disc Disease according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.85 IFNG IL1A IL1B IL6
2 regulation of signaling receptor activity GO:0010469 9.83 IFNG IL1A IL1B IL6
3 negative regulation of cell proliferation GO:0008285 9.8 IL1A IL1B IL6 VDR
4 positive regulation of protein phosphorylation GO:0001934 9.75 IFNG IL1B MMP9
5 cytokine-mediated signaling pathway GO:0019221 9.71 IL1A IL1B IL6 MMP9
6 skeletal system development GO:0001501 9.69 COL9A2 MMP9 VDR
7 endodermal cell differentiation GO:0035987 9.58 COL11A1 MMP9
8 positive regulation of mitotic nuclear division GO:0045840 9.57 IL1A IL1B
9 positive regulation of vascular endothelial growth factor production GO:0010575 9.56 IL1A IL1B
10 extracellular matrix organization GO:0030198 9.56 COL11A1 COL9A2 COL9A3 MMP9
11 positive regulation of gene expression GO:0010628 9.55 IFNG IL1A IL1B IL6 VDR
12 negative regulation of neurogenesis GO:0050768 9.54 IL1B IL6
13 positive regulation of glial cell proliferation GO:0060252 9.48 IL1B IL6
14 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.46 IFNG IL1B
15 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.43 IL1A IL1B
16 ectopic germ cell programmed cell death GO:0035234 9.37 IL1A IL1B
17 positive regulation of neuroinflammatory response GO:0150078 9.32 IL1B IL6
18 fever generation GO:0001660 8.96 IL1A IL1B
19 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 8.62 IFNG IL1B

Molecular functions related to Intervertebral Disc Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.46 IFNG IL1A IL1B IL6
2 interleukin-1 receptor binding GO:0005149 9.26 IL1A IL1B
3 extracellular matrix structural constituent conferring tensile strength GO:0030020 9.13 COL11A1 COL9A2 COL9A3
4 extracellular matrix structural constituent GO:0005201 9.02 CILP COL11A1 COL9A2 COL9A3 THBS2
Sources

Sources for Intervertebral Disc Disease

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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