MCID: INT146
MIFTS: 57

Intervertebral Disc Disease

Categories: Genetic diseases, Rare diseases

Aliases & Classifications for Intervertebral Disc Disease

MalaCards integrated aliases for Intervertebral Disc Disease:

Name: Intervertebral Disc Disease 57 53 25 75 55 40
Intervertebral Disc Degeneration 53 25 44 73
Intervertebral Disc Disorder 25 29 6 73
Lumbar Disc Disease 57 75 55 73
Idd 57 53 25 75
Intervertebral Disc Disease, Susceptibility to 57 13 6
Lumbar Disc Herniation, Susceptibility to 57 6
Lumbar Disc Disease, Susceptibility to 57 6
Lumbar Disc Degeneration 57 75
Lumbar Disc Herniation 57 75
Lumbar Disc Degeneration, Susceptibility to 6
Degeneration of Lumbar Intervertebral Disc 73
Abnormality of the Intervertebral Disk 29
Intervertebral Disk Degeneration 25
Intervertebral Disc Displacement 44
Intervertebral Disk Displacement 73
Disorder of Intervertebral Disc 25
Intervertebral Disk Disease 75
Degenerative Disc Disease 53
Discogenic Disorder 25
Discogenic Disease 25
Ldd 75
Ldh 75

Classifications:



Summaries for Intervertebral Disc Disease

NIH Rare Diseases : 53 Intervertebral disc disease (IDD) is a common musculoskeletal condition that primarily affects the back. It is characterized by intervertebral disc herniation and/or sciatic pain (sciatica) and is a primary cause of low back pain, affecting about 5% of individuals. Both environmental and genetic factors are thought to predispose an individual to developing the condition. Treatment for IDD may include physical therapy, pain medications, and sometimes surgical intervention such as discectomy or spinal fusion.

MalaCards based summary : Intervertebral Disc Disease, also known as intervertebral disc degeneration, is related to degenerative disc disease and spondylosis, and has symptoms including sciatica An important gene associated with Intervertebral Disc Disease is COL9A3 (Collagen Type IX Alpha 3 Chain), and among its related pathways/superpathways are Collagen chain trimerization and Degradation of the extracellular matrix. The drugs Mepivacaine and Peripheral Nervous System Agents have been mentioned in the context of this disorder. Affiliated tissues include bone, spinal cord and bone marrow, and related phenotypes are cardiovascular system and integument

Genetics Home Reference : 25 Intervertebral disc disease is a common condition characterized by the breakdown (degeneration) of one or more of the discs that separate the bones of the spine (vertebrae), causing pain in the back or neck and frequently in the legs and arms. The intervertebral discs provide cushioning between vertebrae and absorb pressure put on the spine.

OMIM : 57 Lumbar disc disease is caused by degeneration of intervertebral discs of the lumbar spine. One of the most common musculoskeletal disorders, it has strong genetic determinants (Matsui et al., 1998; Battie et al., 1995; Sambrook et al., 1999). (603932)

UniProtKB/Swiss-Prot : 75 Intervertebral disc disease: A common musculo-skeletal disorder caused by degeneration of intervertebral disks of the lumbar spine. It results in low-back pain and unilateral leg pain.

Related Diseases for Intervertebral Disc Disease

Diseases related to Intervertebral Disc Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 118)
# Related Disease Score Top Affiliating Genes
1 degenerative disc disease 32.5 ASPN COL9A3 VDR
2 spondylosis 29.8 IL1B VDR
3 back pain 28.7 ASPN CILP COL9A2 COL9A3 MMP9 THBS2
4 lactate dehydrogenase b deficiency 11.8
5 cowden syndrome 1 11.6
6 lactate dehydrogenase deficiency 11.6
7 spondyloepiphyseal dysplasia with congenital joint dislocations 11.1
8 short stature and advanced bone age, with or without early-onset osteoarthritis and/or osteochondritis dissecans 11.1
9 follicular lymphoma 10.9
10 testicular seminoma 10.9
11 fanconi-bickel syndrome 10.9
12 glycogen storage disease due to lactate dehydrogenase deficiency 10.9
13 multiple epiphyseal dysplasia due to collagen 9 anomaly 10.9 COL9A2 COL9A3
14 cauda equina syndrome 10.6
15 diabetic foot ulcers 10.5 IL6 MMP9
16 acute transverse myelitis 10.5 IL6 MMP9
17 vitreoretinal degeneration 10.5 COL11A1 COL9A2
18 recurrent corneal erosion 10.5 IL1B IL6
19 bagassosis 10.5 IL1B IL6
20 photokeratitis 10.5 IL6 MMP9
21 periodontitis, chronic 10.4 IL1B IL6
22 uremic pruritus 10.4 IL1B IL6
23 funisitis 10.4 IL1B IL6
24 glossitis 10.4 IL1B IL6
25 euthyroid sick syndrome 10.4 IL1B IL6
26 transverse myelitis 10.4 IL6 MMP9
27 laryngitis 10.4 IL1B IL6
28 corneal ulcer 10.4 IL1B MMP9
29 ascaris lumbricoides infection 10.4 IL1B IL6
30 acute vascular insufficiency of intestine 10.4 IL1B IL6
31 poems syndrome 10.4 IL1B IL6
32 periapical periodontitis 10.4 IL1B IL6
33 central nervous system vasculitis 10.4 IL1B IL6
34 osteosclerotic myeloma 10.4 IL1B IL6
35 vaginal disease 10.4 IL1B IL6
36 endometrial disease 10.3 IL1B IL6
37 cysticercosis 10.3 IL1B IL6
38 vaginitis 10.3 IL1B IL6
39 transient arthritis 10.3 IL1A IL6
40 cervicitis 10.3
41 primary amebic meningoencephalitis 10.3 IL1B IL6
42 hypochondrogenesis 10.3 ASPN COL11A1
43 irritant dermatitis 10.3 IL1A IL1B
44 autosomal recessive stickler syndrome 10.2 COL11A1 COL9A2 COL9A3
45 bone structure disease 10.2 CILP COL9A3 IL1B
46 stickler syndrome 10.2 COL11A1 COL9A2 COL9A3
47 limbal stem cell deficiency 10.2 IL1A IL1B
48 meningococcemia 10.2 IL1A IL1B
49 hydrarthrosis 10.2 IL1B IL6
50 campylobacteriosis 10.2 IL1B VDR

Comorbidity relations with Intervertebral Disc Disease via Phenotypic Disease Network (PDN):


Acute Cystitis Bronchitis
Chronic Myocardial Ischemia Deficiency Anemia
Esophagitis Heart Disease
Hypertension, Essential Ischemic Heart Disease
Osteoporosis

Graphical network of the top 20 diseases related to Intervertebral Disc Disease:



Diseases related to Intervertebral Disc Disease

Symptoms & Phenotypes for Intervertebral Disc Disease

Clinical features from OMIM:

603932

UMLS symptoms related to Intervertebral Disc Disease:


sciatica

MGI Mouse Phenotypes related to Intervertebral Disc Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.87 IL1A IL1B IL6 MMP11 MMP9 THBS2
2 integument MP:0010771 9.73 IL1A IL1B IL6 MMP9 THBS2 VDR
3 limbs/digits/tail MP:0005371 9.63 MMP9 THBS2 VDR ASPN COL11A1 COL9A2
4 neoplasm MP:0002006 9.43 IL1A IL1B IL6 MMP11 MMP9 THBS2
5 skeleton MP:0005390 9.17 IL1B IL6 MMP9 THBS2 VDR COL11A1

Drugs & Therapeutics for Intervertebral Disc Disease

Drugs for Intervertebral Disc Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 47)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mepivacaine Approved, Vet_approved Phase 1, Phase 2 96-88-8 4062
2 Peripheral Nervous System Agents Phase 1, Phase 2,Not Applicable
3 Calcium, Dietary Phase 1, Phase 2
4 Anesthetics Phase 1, Phase 2,Not Applicable
5 Anesthetics, Local Phase 1, Phase 2,Not Applicable
6 Central Nervous System Depressants Phase 1, Phase 2,Not Applicable
7
Diclofenac Approved, Vet_approved Not Applicable 15307-86-5 3033
8
Clonidine Approved Not Applicable 4205-90-7 2803
9
Lidocaine Approved, Vet_approved Not Applicable 137-58-6 3676
10
Triamcinolone Approved, Vet_approved Not Applicable 124-94-7 31307
11
Folic Acid Approved, Nutraceutical, Vet_approved Not Applicable 59-30-3 6037
12
Thiamine Approved, Investigational, Nutraceutical, Vet_approved Not Applicable 59-43-8, 70-16-6 1130
13 Analgesics Not Applicable
14 Analgesics, Non-Narcotic Not Applicable
15 Anti-Inflammatory Agents Not Applicable
16 Anti-Inflammatory Agents, Non-Steroidal Not Applicable
17 Antirheumatic Agents Not Applicable
18 Cyclooxygenase Inhibitors Not Applicable
19 Micronutrients Not Applicable
20 Trace Elements Not Applicable
21 Vitamin B Complex Not Applicable
22 Vitamins Not Applicable
23 Complement C3
24 Mitogens
25
s 1 (combination)
26 Adrenergic Agents Not Applicable
27 Adrenergic Agonists Not Applicable
28 Adrenergic alpha-2 Receptor Agonists Not Applicable
29 Adrenergic alpha-Agonists Not Applicable
30 Anti-Arrhythmia Agents Not Applicable
31 Antihypertensive Agents Not Applicable
32 Autonomic Agents Not Applicable
33 Diuretics, Potassium Sparing Not Applicable
34 glucocorticoids Not Applicable
35 Hormone Antagonists Not Applicable
36 Hormones Not Applicable
37 Hormones, Hormone Substitutes, and Hormone Antagonists Not Applicable
38 Immunosuppressive Agents Not Applicable
39 Neurotransmitter Agents Not Applicable
40 Sodium Channel Blockers Not Applicable
41 Sympatholytics Not Applicable
42 triamcinolone acetonide Not Applicable
43 Triamcinolone diacetate Not Applicable
44 Triamcinolone hexacetonide Not Applicable
45 Folate Nutraceutical Not Applicable
46 Thiamin Nutraceutical Not Applicable
47 Vitamin B9 Nutraceutical Not Applicable

Interventional clinical trials:

(show all 16)
# Name Status NCT ID Phase Drugs
1 A Study of SI-6603 in Patients With Lumbar Disc Herniation Completed NCT02421601 Phase 3 Condoliase
2 A Study of SI-6603 in Patients With Lumbar Disc Herniation Completed NCT01941563 Phase 3 Condoliase;placebo
3 Clinical Trial Based on the Use of Mesenchymal Stem Cells From Autologous Bone Marrow in Patients With Lumbar Intervertebral Degenerative Disc Disease Completed NCT01513694 Phase 1, Phase 2
4 Treatment of Degenerative Disc Disease With Allogenic Mesenchymal Stem Cells (MSV) Completed NCT01860417 Phase 1, Phase 2 Mepivacaine
5 Electroacupuncture for Sciatica Due to Intervertebral Disc Displacement Unknown status NCT02087462 Not Applicable Voltaren;Vitamin B1
6 Periduroscopy: Correlation Between the Outcome of Procedure and Histological-biochemical, Neuroinflammation and Genetic Factors. Unknown status NCT02076035
7 Alternative and Integrative Therapy for Lumbar Disk Herniation Completed NCT01989403
8 Efficacy of Radiofrequency Nucleoplasty and Targeted Disc Decompression in Lumbar Radiculopathy Completed NCT02025283
9 Triadyme-C, a Polycrystalline Diamond Compact Cervical Disc Replacement (cTDR) Recruiting NCT02967575
10 PASS OCT® Post-market Clinical Follow-up Recruiting NCT02931279
11 Validation of the STarT Back Screening Tool in the Military Recruiting NCT03127826 Not Applicable
12 A Prospective Study of Instrumented, Posterolateral Lumbar Fusions (PLF) With OsteoAMP® Active, not recruiting NCT02225444
13 Efficacy Study of NuCel® in Patients Undergoing Fusion of the Lumbar Spine Active, not recruiting NCT02023372 Not Applicable
14 Clinical and Radiological Evaluation of Patients With DDD Following TLIF With 3-D Printed Titanium Cage Enrolling by invitation NCT03018392 Not Applicable
15 Epidural Clonidine for Lumbosacral Radiculopathy Terminated NCT00588354 Not Applicable Clonidine;Triamcinolone hexacetonide;Lidocaine HCl
16 A Prospective Study of NuCel® in Cervical Spine Fusion Terminated NCT02381067 Not Applicable

Search NIH Clinical Center for Intervertebral Disc Disease

Cochrane evidence based reviews: intervertebral disc displacement

Genetic Tests for Intervertebral Disc Disease

Genetic tests related to Intervertebral Disc Disease:

# Genetic test Affiliating Genes
1 Intervertebral Disc Disorder 29 ASPN CILP COL11A1 COL9A2 COL9A3 THBS2
2 Abnormality of the Intervertebral Disk 29

Anatomical Context for Intervertebral Disc Disease

MalaCards organs/tissues related to Intervertebral Disc Disease:

41
Bone, Spinal Cord, Bone Marrow

Publications for Intervertebral Disc Disease

Articles related to Intervertebral Disc Disease:

(show top 50) (show all 103)
# Title Authors Year
1
Ventral Slot Surgery to Manage Cervical Intervertebral Disc Disease in Three Cats. ( 29325196 )
2018
2
Canine pancreatic lipase immunoreactivity concentrations associated with intervertebral disc disease in 84 dogs. ( 29355958 )
2018
3
Retraction Notice: Lack of Relationship Between Occupational Workload and Microscopic Alterations in Lumbar Intervertebral Disc Disease. ( 28932331 )
2017
4
Increased volume of lumbar surgeries for herniated intervertebral disc disease and cost-effectiveness analysis: a nationwide cohort study. ( 29095409 )
2017
5
<i>FGF4</i> retrogene on CFA12 is responsible for chondrodystrophy and intervertebral disc disease in dogs. ( 29073074 )
2017
6
Asthma and early herniated intervertebral disc disease. ( 28498027 )
2017
7
Bone Marrow-Derived Mesenchymal Stem Cells as Autologous Therapy in Dogs with Naturally Occurring Intervertebral Disc Disease: Feasibility, Safety and Preliminary Results. ( 28471303 )
2017
8
Correlation of matrix metalloproteinase (MMP)-1, -2, -3, and -9 expressions with demographic and radiological features in primary lumbar intervertebral disc disease. ( 28343922 )
2017
9
Serum levels of the proinflammatory cytokine interleukin-6 vary based on diagnoses in individuals with lumbar intervertebral disc diseases. ( 26743937 )
2016
10
Genetic Alterations in Intervertebral Disc Disease. ( 27917384 )
2016
11
ICD-10: Intervertebral Disc Disease. ( 27514110 )
2016
12
Prevalence and breed predisposition for thoracolumbar intervertebral disc disease in cats. ( 26868632 )
2016
13
The efficacy of interlaminar epidural steroid administration in multilevel intervertebral disc disease with chronic low back pain: a randomized, blinded, prospective Study. ( 27555486 )
2016
14
Evaluation of the Association Between Matrix Metalloproteinase 11 and Intervertebral Disc Disease. ( 26956825 )
2016
15
DachsLife 2015: an investigation of lifestyle associations with the risk of intervertebral disc disease in Dachshunds. ( 27826450 )
2016
16
Association between COL9A2 Gln326Arg mutations and the development of intervertebral disc disease in a Chinese population. ( 28002589 )
2016
17
Complex Regional Pain Syndrome Caused by Lumbar Herniated Intervertebral Disc Disease. ( 27454281 )
2016
18
Thoracolumbar partial lateral corpectomy for the treatment of chronic intervertebral disc disease in 107 dogs. ( 26629329 )
2015
19
Developments in intervertebral disc disease research: pathophysiology, mechanobiology, and therapeutics. ( 25694233 )
2015
20
Lack of relationship between occupational workload and microscopic alterations in lumbar intervertebral disc disease. ( 25136392 )
2014
21
Intervertebral disc disease in Dachshunds radiographically screened for intervertebral disc calcifications. ( 25523328 )
2014
22
Neurologic outcome after thoracolumbar partial lateral corpectomy for intervertebral disc disease in 72 dogs. ( 24484371 )
2014
23
Advancing the cellular and molecular therapy for intervertebral disc disease. ( 24993611 )
2014
24
Clinical correlation of magnetic resonance imaging with symptom complex in prolapsed intervertebral disc disease: A cross-sectional double blind analysis. ( 24381451 )
2013
25
Reoperation rate after surgery for lumbar herniated intervertebral disc disease: nationwide cohort study. ( 23023591 )
2013
26
Effect of ventral slot procedure on spinal cord compression in dogs with single static intervertebral disc disease: preliminary findings while evaluating a semiquantitative computed tomographic myelographic score of spinal cord compression. ( 23240963 )
2013
27
Acute adverse events associated with ventral slot decompression in 546 dogs with cervical intervertebral disc disease. ( 23980621 )
2013
28
Spatio-temporal development of axonopathy in canine intervertebral disc disease as a translational large animal model for nonexperimental spinal cord injury. ( 22805224 )
2013
29
Screening of genes related with intervertebral disc disease by dynamic differential interaction network analysis. ( 24338460 )
2013
30
The vacuum phenomenon in intervertebral disc disease of dogs based on computed tomography images. ( 23565773 )
2013
31
Intervertebral disc disease in dogs - part 1: a new histological grading scheme for classification of intervertebral disc degeneration in dogs. ( 22789628 )
2013
32
Correlations between severity of clinical signs and histopathological changes in 60 dogs with spinal cord injury associated with acute thoracolumbar intervertebral disc disease. ( 23702280 )
2013
33
Intervertebral disc disease in dogs - part 2: comparison of clinical, magnetic resonance imaging, and histological findings in 74 surgically treated dogs. ( 22795604 )
2013
34
Association between single nucleotide polymorphism in collagen IX and intervertebral disc disease in the Indian population. ( 22912517 )
2012
35
Surgical management of first caudal nerve root foraminal compression secondary to intervertebral disc disease in a Cocker Spaniel. ( 22105313 )
2012
36
Magnetic resonance imaging diagnosis of intervertebral disc disease and myelomalacia in an American black bear (Ursus americanus). ( 22779249 )
2012
37
Residual herniated disc material following hemilaminectomy in chondrodystrophic dogs with thoracolumbar intervertebral disc disease. ( 22286190 )
2012
38
Magnetic resonance imaging enhancement of intervertebral disc disease in 30 dogs following chemical fat saturation. ( 22250714 )
2012
39
Comparison of computed tomography and myelography to a reference standard of computed tomographic myelography for evaluation of dogs with intervertebral disc disease. ( 22091972 )
2012
40
Agreement between T2 and haste sequences in the evaluation of thoracolumbar intervertebral disc disease in dogs. ( 22168798 )
2012
41
Computed tomographic characteristics of acute thoracolumbar intervertebral disc disease in dogs. ( 20195068 )
2010
42
Intervertebral disc disease in dogs. ( 20732594 )
2010
43
Acupuncture treatment for feline multifocal intervertebral disc disease. ( 19186087 )
2009
44
Detection of spinal cord compression in dogs with cervical intervertebral disc disease by magnetic resonance imaging. ( 18603629 )
2008
45
Future perspectives of cell-based therapy for intervertebral disc disease. ( 19005704 )
2008
46
A critical evaluation of discography in patients with lumbar intervertebral disc disease. ( 18069067 )
2008
47
Continuous lumbar hemilaminectomy for intervertebral disc disease in an Amur tiger (Panthera tigris altaica). ( 18817014 )
2008
48
Randomized, blinded, placebo-controlled clinical trial of N-acetylcysteine in dogs with spinal cord trauma from acute intervertebral disc disease. ( 18520934 )
2008
49
Occupational and genetic risk factors associated with intervertebral disc disease. ( 17471097 )
2007
50
Acute non-ambulatory tetraparesis attributable to cranial cervical intervertebral disc disease in a cat. ( 17560823 )
2007

Variations for Intervertebral Disc Disease

UniProtKB/Swiss-Prot genetic disease variations for Intervertebral Disc Disease:

75
# Symbol AA change Variation ID SNP ID
1 COL9A2 p.Gln326Trp VAR_012658 rs137853213

ClinVar genetic disease variations for Intervertebral Disc Disease:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 ASPN NM_017680.4(ASPN): c.112_114GAT(14) (p.Asp50_Glu51insAsp) NT expansion risk factor rs387906276 GRCh37 Chromosome 9, 95237030: 95237032
2 ASPN NM_017680.4(ASPN): c.112_114GAT(14) (p.Asp50_Glu51insAsp) NT expansion risk factor rs387906276 GRCh38 Chromosome 9, 92474748: 92474750
3 CILP NM_003613.3(CILP): c.1184T> C (p.Ile395Thr) single nucleotide variant risk factor rs2073711 GRCh37 Chromosome 15, 65494212: 65494212
4 CILP NM_003613.3(CILP): c.1184T> C (p.Ile395Thr) single nucleotide variant risk factor rs2073711 GRCh38 Chromosome 15, 65201874: 65201874
5 THBS2 NM_003247.3(THBS2): c.1478-8C> T single nucleotide variant risk factor rs9406328 GRCh38 Chromosome 6, 169234915: 169234915
6 THBS2 NM_003247.3(THBS2): c.1478-8C> T single nucleotide variant risk factor rs9406328 GRCh37 Chromosome 6, 169635010: 169635010
7 COL9A3 NM_001853.3(COL9A3): c.307C> T (p.Arg103Trp) single nucleotide variant risk factor rs61734651 GRCh37 Chromosome 20, 61451332: 61451332
8 COL9A3 NM_001853.3(COL9A3): c.307C> T (p.Arg103Trp) single nucleotide variant risk factor rs61734651 GRCh38 Chromosome 20, 62819980: 62819980
9 COL9A2 NM_001852.3(COL9A2): c.2059A> G (p.Lys687Glu) single nucleotide variant Uncertain significance rs201847956 GRCh38 Chromosome 1, 40301193: 40301193
10 COL9A2 NM_001852.3(COL9A2): c.2059A> G (p.Lys687Glu) single nucleotide variant Uncertain significance rs201847956 GRCh37 Chromosome 1, 40766865: 40766865

Expression for Intervertebral Disc Disease

Search GEO for disease gene expression data for Intervertebral Disc Disease.

Pathways for Intervertebral Disc Disease

Pathways related to Intervertebral Disc Disease according to GeneCards Suite gene sharing:

(show all 34)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.67 COL11A1 COL9A2 COL9A3 MMP9
2
Show member pathways
12.29 ASPN COL11A1 COL9A2 COL9A3 MMP11 MMP9
3
Show member pathways
12.11 IL1A IL1B IL6
4
Show member pathways
12.07 IL1A IL1B IL6
5 12.03 IL6 MMP11 MMP9
6 12.02 IL1A IL1B IL6
7 12.01 IL1A IL1B IL6 VDR
8
Show member pathways
11.97 COL9A2 COL9A3 THBS2
9 11.94 IL1A IL1B MMP9
10 11.82 IL1B IL6 MMP9
11 11.81 IL1A IL1B IL6
12 11.77 IL1A IL1B IL6
13
Show member pathways
11.76 MMP11 MMP9 THBS2
14 11.75 IL1A IL1B IL6
15 11.71 IL1A IL1B IL6
16 11.7 IL1A IL1B IL6 MMP9
17 11.68 IL1A IL1B IL6
18 11.61 IL1A IL1B IL6
19 11.61 IL1A IL1B IL6 MMP9
20 11.51 IL1B IL6 MMP9
21 11.46 ASPN COL9A2 COL9A3
22 11.38 IL1A IL1B IL6
23 11.36 IL1B IL6 THBS2
24 11.33 IL1A IL1B IL6
25 11.19 IL6 MMP9
26 11.16 IL1B IL6
27 11.15 IL1B IL6
28 11.15 IL1A IL1B IL6
29 11.12 IL1A IL1B IL6
30
Show member pathways
11.06 IL1A IL1B IL6 MMP9
31 11.04 IL1B MMP9
32 11.02 IL1A IL1B IL6
33 10.58 IL1A IL1B IL6 VDR
34 10.39 IL1A IL1B

GO Terms for Intervertebral Disc Disease

Cellular components related to Intervertebral Disc Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.8 CILP COL11A1 IL1A IL1B IL6 MMP9
2 extracellular region GO:0005576 9.65 ASPN COL11A1 COL9A2 COL9A3 IL1A IL1B
3 endoplasmic reticulum lumen GO:0005788 9.62 COL11A1 COL9A2 COL9A3 IL6
4 collagen trimer GO:0005581 9.54 COL11A1 COL9A2 COL9A3
5 collagen type IX trimer GO:0005594 9.16 COL9A2 COL9A3
6 extracellular matrix GO:0031012 9.1 ASPN CILP COL11A1 MMP11 MMP9 THBS2

Biological processes related to Intervertebral Disc Disease according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.78 IL1A IL1B IL6 VDR
2 positive regulation of gene expression GO:0010628 9.76 IL1A IL1B IL6 VDR
3 skeletal system development GO:0001501 9.67 COL9A2 MMP9 VDR
4 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.55 IL1A IL1B
5 endodermal cell differentiation GO:0035987 9.54 COL11A1 MMP9
6 positive regulation of vascular endothelial growth factor production GO:0010575 9.52 IL1A IL1B
7 positive regulation of mitotic nuclear division GO:0045840 9.51 IL1A IL1B
8 collagen catabolic process GO:0030574 9.5 COL11A1 MMP11 MMP9
9 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.43 IL1A IL1B
10 positive regulation of monocyte chemotactic protein-1 production GO:0071639 9.4 IL1A IL1B
11 ectopic germ cell programmed cell death GO:0035234 9.37 IL1A IL1B
12 cytokine-mediated signaling pathway GO:0019221 9.35 ASPN IL1A IL1B IL6 MMP9
13 positive regulation of interleukin-6 production GO:0032755 9.33 IL1A IL1B IL6
14 fever generation GO:0001660 9.26 IL1A IL1B
15 extracellular matrix organization GO:0030198 9.1 COL11A1 COL9A2 COL9A3 MMP11 MMP9 THBS2

Molecular functions related to Intervertebral Disc Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 interleukin-1 receptor binding GO:0005149 8.96 IL1A IL1B
2 extracellular matrix structural constituent conferring tensile strength GO:0030020 8.62 COL9A2 COL9A3

Sources for Intervertebral Disc Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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