IDD
MCID: INT146
MIFTS: 62

Intervertebral Disc Disease (IDD)

Categories: Bone diseases, Genetic diseases, Muscle diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Intervertebral Disc Disease

MalaCards integrated aliases for Intervertebral Disc Disease:

Name: Intervertebral Disc Disease 56 52 25 73 54 39
Intervertebral Disc Degeneration 52 25 43 71
Intervertebral Disc Disorder 25 29 6 71
Lumbar Disc Disease 56 73 54 71
Idd 56 52 25 73
Intervertebral Disc Disease, Susceptibility to 56 13 6
Lumbar Disc Degeneration 56 73 17
Lumbar Disc Herniation 56 73 17
Lumbar Disc Herniation, Susceptibility to 56 6
Lumbar Disc Disease, Susceptibility to 56 6
Intervertebral Disc Displacement 43 17
Lumbar Disc Degeneration, Susceptibility to 6
Degeneration of Lumbar Intervertebral Disc 71
Abnormality of the Intervertebral Disk 29
Intervertebral Disk Degeneration 25
Intervertebral Disk Displacement 71
Disorder of Intervertebral Disc 25
Intervertebral Disk Disease 73
Degenerative Disc Disease 52
Discogenic Disorder 25
Discogenic Disease 25
Ldd 73
Ldh 73

Classifications:



External Ids:

OMIM 56 603932
UMLS 71 C0021818 C0158252 C0158266 more

Summaries for Intervertebral Disc Disease

Genetics Home Reference : 25 Intervertebral disc disease is a common condition characterized by the breakdown (degeneration) of one or more of the discs that separate the bones of the spine (vertebrae), causing pain in the back or neck and frequently in the legs and arms. The intervertebral discs provide cushioning between vertebrae and absorb pressure put on the spine. While the discs in the lower (lumbar) region of the spine are most often affected in intervertebral disc disease, any part of the spine can have disc degeneration. Depending on the location of the affected disc or discs, intervertebral disc disease can cause periodic or chronic pain in the back or neck. Pain is often worse when sitting, bending, twisting, or lifting objects. Degenerated discs are prone to out-pouching (herniation); the protruding disc can press against one of the spinal nerves that run from the spinal cord to the rest of the body. This pressure causes pain, weakness, and numbness in the back and legs. Herniated discs often cause nerve pain called sciatica that travels along the sciatic nerve, which runs from the lower back down the length of each leg. As a disc degenerates, small bony outgrowths (bone spurs) may form at the edges of the affected vertebrae. These bone spurs may pinch (compress) the spinal nerves, leading to weakness or numbness in the arms or legs. If the bone spurs compress the spinal cord, affected individuals can develop problems with walking and bladder and bowel control. Over time, a degenerating disc may break down completely and leave no space between vertebrae, which can result in impaired movement, pain, and nerve damage.

MalaCards based summary : Intervertebral Disc Disease, also known as intervertebral disc degeneration, is related to spondyloepiphyseal dysplasia with congenital joint dislocations and degenerative disc disease, and has symptoms including sciatica An important gene associated with Intervertebral Disc Disease is CILP (Cartilage Intermediate Layer Protein), and among its related pathways/superpathways are ERK Signaling and Phospholipase-C Pathway. The drugs Norepinephrine and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include bone, spinal cord and testes, and related phenotypes are homeostasis/metabolism and integument

NIH Rare Diseases : 52 Intervertebral disc disease (IDD) is a common musculoskeletal condition that primarily affects the back. It is characterized by intervertebral disc herniation and/or sciatic pain (sciatica) and is a primary cause of low back pain, affecting about 5% of individuals. Both environmental and genetic factors are thought to predispose an individual to developing the condition. Treatment for IDD may include physical therapy , pain medications, and sometimes surgical intervention such as discectomy or spinal fusion .

OMIM : 56 Lumbar disc disease is caused by degeneration of intervertebral discs of the lumbar spine. One of the most common musculoskeletal disorders, it has strong genetic determinants (Matsui et al., 1998; Battie et al., 1995; Sambrook et al., 1999). (603932)

UniProtKB/Swiss-Prot : 73 Intervertebral disc disease: A common musculo-skeletal disorder caused by degeneration of intervertebral disks of the lumbar spine. It results in low-back pain and unilateral leg pain.

Related Diseases for Intervertebral Disc Disease

Diseases related to Intervertebral Disc Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 685)
# Related Disease Score Top Affiliating Genes
1 spondyloepiphyseal dysplasia with congenital joint dislocations 31.7 COL9A3 COL9A2 COL11A2 COL11A1
2 degenerative disc disease 30.9 VDR COL9A3 ASPN
3 multiple epiphyseal dysplasia, autosomal dominant 30.7 COL9A3 COL9A2
4 traumatic brain injury 30.2 MMP9 IL6
5 back pain 29.9 THBS2 MMP9 COL9A3 COL9A2 CILP ASPN
6 arthropathy 29.8 IL6 IL1B IFNG
7 aortic aneurysm 29.8 MMP9 IL6 COL11A1
8 bronchitis 29.8 MMP9 IL6 IL1B
9 gastric ulcer 29.6 MMP9 IL6 IL1B
10 keratitis, hereditary 29.6 MMP9 IL6 IL1B
11 meningitis 29.6 MMP9 IL6 IL1B IFNG
12 spondyloarthropathy 29.5 IL6 IL1B IFNG
13 atherosclerosis susceptibility 29.5 MMP9 IL6 IL1B
14 pericarditis 29.4 IL6 IL1B IFNG
15 pyelonephritis 29.4 IL6 IL1B IFNG
16 peritonitis 29.4 IL6 IL1B IFNG
17 spinal stenosis 29.3 THBS2 COL9A3 COL9A2 COL11A2 COL11A1
18 juvenile rheumatoid arthritis 29.2 IL6 IL1B IFNG
19 pulmonary tuberculosis 29.2 VDR IL6 IFNG
20 neuritis 29.2 MMP9 IL6 IL1B IFNG
21 demyelinating disease 29.2 MMP9 IL6 IL1B IFNG
22 conjunctivitis 29.2 MMP9 IL6 IFNG
23 bacterial infectious disease 29.1 IL6 IL1B IL1A IFNG
24 pneumonia 29.1 MMP9 IL6 IL1B IFNG
25 bacterial meningitis 29.1 MMP9 IL6 IL1B IFNG
26 central nervous system disease 29.0 MMP9 IL6 IL1B IFNG
27 nervous system disease 29.0 MMP9 IL6 IL1B IFNG
28 uveitis 29.0 IL6 IL1A IFNG
29 measles 29.0 IL6 IL1B IFNG
30 aseptic meningitis 29.0 IL1B IL1A IFNG
31 myocarditis 29.0 IL6 IL1B IFNG
32 prostatitis 29.0 VDR IL6 IL1B IL1A
33 tetanus 28.9 IL6 IL1B IFNG
34 dermatitis, atopic 28.9 IL6 IL1B IL1A IFNG
35 osteomyelitis 28.8 IL6 IL1B IL1A IFNG
36 connective tissue disease 28.8 IL6 IL1B IL1A IFNG
37 bone disease 28.8 VDR MMP9 IL6 IL1B IL1A
38 hashimoto thyroiditis 28.8 VDR IL6 IL1B IFNG
39 leprosy 3 28.8 VDR IL6 IL1B IFNG
40 myelodysplastic syndrome 28.7 MMP9 IL6 IL1B IL1A IFNG
41 typhoid fever 28.6 IL6 IL1B IL1A IFNG
42 psoriasis 28.6 VDR IL6 IL1B IL1A IFNG
43 myocardial infarction 28.5 THBS2 MMP9 IL6 IL1B IFNG
44 skin disease 28.5 VDR IL6 IL1A IFNG
45 proteasome-associated autoinflammatory syndrome 1 28.5 MMP9 IL6 IL1B IL1A IFNG
46 primary biliary cirrhosis 28.4 VDR IL6 IL1B IFNG
47 diabetes mellitus, insulin-dependent 28.3 VDR IL6 IL1B IFNG
48 retinal detachment 28.3 MMP9 IL6 IFNG COL9A2 COL11A1
49 rheumatoid arthritis 28.3 MMP9 IL6 IL1B IL1A IFNG CILP
50 osteoarthritis 28.3 MMP9 IL6 IL1B IL1A COL11A2 CILP

Comorbidity relations with Intervertebral Disc Disease via Phenotypic Disease Network (PDN):


Acute Cystitis Bronchitis
Deficiency Anemia Esophagitis
Heart Disease Hypertension, Essential
Osteoporosis

Graphical network of the top 20 diseases related to Intervertebral Disc Disease:



Diseases related to Intervertebral Disc Disease

Symptoms & Phenotypes for Intervertebral Disc Disease

Clinical features from OMIM:

603932

UMLS symptoms related to Intervertebral Disc Disease:


sciatica

MGI Mouse Phenotypes related to Intervertebral Disc Disease:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.96 CILP COL11A2 COL9A2 IFNG IL1A IL1B
2 integument MP:0010771 9.76 CILP IFNG IL1A IL1B IL6 MMP9
3 hearing/vestibular/ear MP:0005377 9.72 ASPN COL11A1 COL11A2 COL9A2 VDR
4 neoplasm MP:0002006 9.43 IFNG IL1A IL1B IL6 MMP9 THBS2
5 skeleton MP:0005390 9.28 COL11A1 COL11A2 COL9A2 IFNG IL1B IL6

Drugs & Therapeutics for Intervertebral Disc Disease

Drugs for Intervertebral Disc Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 177)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Norepinephrine Approved Phase 4 51-41-2 439260
2
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
3
Coal tar Approved Phase 4 8007-45-2
4
Pregabalin Approved, Investigational Phase 4 148553-50-8 5486971
5
Cefuroxime Approved Phase 4 55268-75-2 5361202 5479529
6
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
7
Eplerenone Approved Phase 4 107724-20-9 150310 443872
8
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
9
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
10
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
11
Flurbiprofen Approved, Investigational Phase 4 5104-49-4 3394
12
Calcium Approved, Nutraceutical Phase 4 7440-70-2 271
13 Flurbiprofen axetil Investigational Phase 4 91503-79-6
14 Trace Elements Phase 4
15 Micronutrients Phase 4
16 Dopamine Agents Phase 4
17 Duloxetine Hydrochloride Phase 4
18 Serotonin and Noradrenaline Reuptake Inhibitors Phase 4
19 Antidepressive Agents Phase 4
20 Immunologic Factors Phase 4
21 Calcium, Dietary Phase 4
22 Anti-Infective Agents Phase 4
23 calcium channel blockers Phase 4
24 Anticonvulsants Phase 4
25 cefuroxime axetil Phase 4
26 Antibiotics, Antitubercular Phase 4
27 Anti-Bacterial Agents Phase 4
28 Triamcinolone hexacetonide Phase 4
29 triamcinolone acetonide Phase 4
30 Triamcinolone diacetate Phase 4
31 Immunosuppressive Agents Phase 4
32 Pharmaceutical Solutions Phase 4
33 Diuretics, Potassium Sparing Phase 4
34 Antihypertensive Agents Phase 4
35 Natriuretic Agents Phase 4
36 Mineralocorticoids Phase 4
37 Mineralocorticoid Receptor Antagonists Phase 4
38 diuretics Phase 4
39 HIV Protease Inhibitors Phase 4
40
protease inhibitors Phase 4
41 BB 1101 Phase 4
42 Anti-Inflammatory Agents, Non-Steroidal Phase 4
43 Analgesics, Non-Narcotic Phase 4
44 Antirheumatic Agents Phase 4
45
Adalimumab Approved Phase 3 331731-18-1 16219006
46
tannic acid Approved Phase 3 1401-55-4
47
Benzocaine Approved, Investigational Phase 3 1994-09-7, 94-09-7 2337
48
Gabapentin Approved, Investigational Phase 3 60142-96-3 3446
49
Lidocaine Approved, Vet_approved Phase 2, Phase 3 137-58-6 3676
50
Epinephrine Approved, Vet_approved Phase 3 51-43-4 5816

Interventional clinical trials:

(show top 50) (show all 494)
# Name Status NCT ID Phase Drugs
1 Duloxetine as an Analgesic Agent in Patients Undergoing Elective Spine Surgery Unknown status NCT02535000 Phase 4 Duloxetine;Placebo
2 Single Center, Randomized PROspective Study Comparing Percutaneous HydroDiscectomy to Transforaminal Epidural Steroid Injections in the Treatment Of Radiculopathy Secondary to Lumbar Disc Herniation (PROPHESOR) Unknown status NCT02414698 Phase 4 TESI
3 A Prospective Randomized Trails for Primary Disc Herniation With Radiculopathy:Conservative Versus Aggressive Discectomy Unknown status NCT01204008 Phase 4
4 A Prospective Study of the InterFuse T(tm) Unknown status NCT02678130 Phase 4
5 Prospective, Randomized, Single Blind Trial on the Effects of Paravertebral Intramuscular Oxygen-ozone Therapy on Back Pain in Subjects Aged 65 or Older Unknown status NCT01709058 Phase 4 Intramuscular/paravertebral injections of Oxygen-Ozone
6 A Multi-center, Post Marketing Surveillance Study to Monitor the Safety and Performance of the Barricaid® ARD in the Treatment of Back and Radicular Pain Caused by Primary Lumbar Disc Herniation Completed NCT01534065 Phase 4
7 Evaluation of Fusion Rate of Anterior Cervical Discectomy and Fusion (ACDF) Using Cervios ChronOs™ and Bonion™ Completed NCT01615328 Phase 4
8 Analgetic and Anxiolytic Effect of Preoperative Pregabalin in Patients Undergoing Surgery of the Vertebral Columna Completed NCT00353704 Phase 4 pregabalin;Placebo;morphine
9 Study of an Expandable Interbody Device for the Lumbar Spine Completed NCT02075554 Phase 4
10 Comparison of Internal Disc Decompression (IDD) vs. a Standardized Non-surgical Treatment Program for Chronic Low Back Pain Secondary to Mild to Moderate Degenerative Disc Disease (DDD) Completed NCT00165893 Phase 4
11 A Prospective, Multi-Center, Post-Market Surveillance Study to Assess the Clinical Efficacy and Fusion Rates of the Zimmer TM Ardis Interbody Fusion System Completed NCT02429908 Phase 4
12 Prospective, Double-Blind, Randomized, Placebo-Controlled Trial of Single-Dose Cefuroxime Prophylaxis in Herniated Disk Surgery Completed NCT00530400 Phase 4 cefuroxime;placebo
13 Comparison of Perioperative Outcome Between Corticosteroids and Placebo in Transforaminal Endoscopic Lumbar Discectomy. A Single-center Randomized Placebo-controlled Trial. Completed NCT03273036 Phase 4 40 mg Triamcinolone acetate 1 cc;Placebos
14 Efficacy of Pregabalin in Patients With Radicular Pain Completed NCT00908375 Phase 4 Pregabalin;Sugar Pill
15 Opioid Treatment for Chronic Low Back Pain and the Impact of Mood Symptoms Completed NCT01502644 Phase 4 Oxycodone;Morphine;Placebo
16 Randomized Study of Anular Repair With the Xclose Tissue Repair System Completed NCT00760799 Phase 4
17 Efficacy Study of Caudal Epidural Steroid Injections in Patients With Low Back Pain/Radiculopathy Completed NCT01407913 Phase 4
18 Study Of Disc Anaesthesia For The Preoperative Diagnosis Of Chronic Lower Back Pain Completed NCT00443781 Phase 4
19 Spine Patient Outcomes Research Trial (SPORT): A Multicenter Randomized Trial for Intervertebral Disc Herniation (IDH) Completed NCT00000410 Phase 4
20 Epidural Steroid Injection With Supplemental Oral Eplerenone for Low Back Pain: A Prospective, Double Blind Randomized Trial Recruiting NCT03418649 Phase 4 Eplerenone 50 Mg Tab;Placebo Oral Tablet
21 A Prospective, Single Arm Study of Patients Undergoing Posterolateral Lumbar Fusion (Without Interbody) Supplemented With ViviGen Cellular Bone Matrix Recruiting NCT04007094 Phase 4 ViviGen Cellular Bone Matrix
22 Subjective Intraoperative Use of Epidural Steroid Administration Following Discectomy for Herniated Lumbar Discs Is There a Role? - A Randomized Control Trial Recruiting NCT04182997 Phase 4 Dexamethasone;saline 0.9%
23 Combined Administration of Bupivacaine and Exparel Versus Bupivacaine or Exparel Alone for Postoperative Analgesia in Posterior Lumbar Spine Surgery - A Prospective Randomized Study Recruiting NCT03514277 Phase 4 Exparel;Bupivacaine
24 Percutaneous Transforaminal Endoscopic Discectomy (PTED) Versus Microendoscopic Discectomy (MED) for the Treatment of Lumbar Disc Herniation: A Prospective Randomized Controlled Study Active, not recruiting NCT01997086 Phase 4
25 A Prospective, Randomized, Multicenter Study to Demonstrate the Superiority of the Barricaid to Discectomy for Primary Lumbar Disc Herniation Active, not recruiting NCT01283438 Phase 4
26 A Post Marketing Surveillance Study To Monitor The Early Safety And Performance Of The BARRICAID® Anular Closure Device In The Treatment Of Radicular Pain Caused By Primary Lumbar Disc Herniation Active, not recruiting NCT03366779 Phase 4
27 Clinical and Radiographic Outcomes of BIO4 Bone Matrix in Patients Undergoing 1 or 2-Level Anterior Cervical Discectomy and Fusion Surgery Active, not recruiting NCT03077204 Phase 4
28 Post Market Non-Inferiority Study Comparing Triojection® to Discectomy for Lumbar Disc Herniation Active, not recruiting NCT02525120 Phase 4
29 Clinical Investigation of NanoFUSE® Bioactive Matrix and Autogenous Bone in Posterolateral Spinal Fusion (Nonloadbearing) Not yet recruiting NCT03751943 Phase 4
30 Efficacy and Safety of Ultrasound-guided Lateral Thoracolumbar Interfascial Plane Block (TLIPB) for Postoperative Pain in Patients Undergoing Herniated Lumbar Disc Surgery: A Randomized Clinical Trial. Not yet recruiting NCT03951038 Phase 4
31 A Multi-Centre, Prospective, Randomized, Post Marketing Surveillance Study Comparing Cervical Arthroplasty to Anterior Cervical Discectomy and Fusion (ACDF) for the Treatment of Cervical Degenerative Disc Disease Terminated NCT00700739 Phase 4
32 Lumbar Interbody Fusion Using The Telamon® Peek™ Versus The Telamon® Hydrosorb™ Fusion Device - A Prospective, Randomized Controlled Trial To Assess Surgical And Clinical Outcomes Terminated NCT00095095 Phase 4
33 Efficacy Study Using Solum IV, Bone Marrow Concentrate With General Fluid Concentrate in Transforaminal Lumbar Interbody Fusion Withdrawn NCT03223701 Phase 4
34 Percutaneous Lumbar Discectomy (PLD) Combined With Ozone Versus Percutaneous Lumbar Discectomy (PLD) for Treatment of Lumbar Disc Herniation:A Single-Blind Prospective Randomized Controlled Trial Unknown status NCT02372032 Phase 3
35 Wallis Mechanical Normalization System for Low Back Pain Unknown status NCT00134537 Phase 3
36 A Prospective, Multi-center, Randomized, Active-Controlled Study of the Wallis System for the Treatment of Mild to Moderate Degenerative Disc Disease of the Lumbar Spine Unknown status NCT00484458 Phase 3
37 Adalimumab (Anti TNF Alfa) in the Management of Acute Lumbar Disc Prolapses - a One Year, Randomized, Placebo Controlled, Double Blind, Single Center Trial Unknown status NCT01510548 Phase 3
38 A Study of SI-6603 in Patients With Lumbar Disc Herniation Completed NCT01941563 Phase 3 Condoliase;placebo
39 A Multicenter, Open-label Study of SI 6603 in Patients With Lumbar Disc Herniation (Phase III) Completed NCT02421601 Phase 3 Condoliase
40 A Pivotal, Multi-Center, Clinical Trial Evaluating The Safety And Effectiveness of The Lumbar TDR Device In Patients With Single-Level Lumbar Degenerative Disc Disease Completed NCT00927238 Phase 3
41 A Prospective, Multicenter, Randomized Study Comparing the Use of HEALOS® to Autograft in a Transforaminal Lumbar Interbody Fusion (TLIF) Approach Completed NCT00316121 Phase 3
42 Assessment of the Efficacy of an Intradiscal Injection of Corticoids in Modic I Discopathies. Completed NCT01694134 Phase 3 Hydrocortancyl.;Lidocaine
43 A Multi-center Study to Evaluate the Safety and Efficacy of DePuy AcroMed Titanium Surgical Mesh and MOSS-Miami Spinal Fixation System Pedicle Screws for Intradiscal Fusion in the Lumbar Spine Completed NCT00215319 Phase 3
44 A Prospective, Randomized Clinical Investigation of rhBMP-2 and Compression Resistant Matrix With the CD HORIZON® Spinal System for Posterolateral Lumbar Fusion in Patients With Symptomatic Degenerative Disc Disease Completed NCT00707265 Phase 3
45 A Prospective, Multicenter, Controlled Clinical Trial of an Artificial Cervical Disc LP at a Single Level for Symptomatic Cervical Disc Disease Completed NCT00667459 Phase 3
46 Clinical Investigation of the SB Charite III Intervertebral Disc Spacer. Completed NCT00215306 Phase 3
47 A Randomized Multi-Center Study to Evaluate the Safety and Efficacy of the Cervical I/F Cage for Anterior Cervical Fusion Completed NCT00215293 Phase 3
48 Co-analgesic Effects of Dexamethasone and Pregabalin After Lumbar Slipped Disc Surgery Completed NCT01811251 Phase 3 Pregabaline (150mg), Dexamethasone (20mg/5ml; 0.2mg/kg)
49 A Multicenter, Randomized, Double-blind Recommended Dose-finding Study of SI-6603 in Patients With Lumbar Disc Herniation (Phase II/III Study) Completed NCT00634946 Phase 2, Phase 3 SI-6603;Placebo
50 Neurosurgery Patient Outcomes in Treating Spinal Disorders Completed NCT01220921 Phase 3

Search NIH Clinical Center for Intervertebral Disc Disease

Cochrane evidence based reviews: intervertebral disc degeneration

Genetic Tests for Intervertebral Disc Disease

Genetic tests related to Intervertebral Disc Disease:

# Genetic test Affiliating Genes
1 Intervertebral Disc Disorder 29 ASPN CILP COL11A1 THBS2
2 Abnormality of the Intervertebral Disk 29

Anatomical Context for Intervertebral Disc Disease

MalaCards organs/tissues related to Intervertebral Disc Disease:

40
Bone, Spinal Cord, Testes, T Cells, Bone Marrow, Lung, Brain

Publications for Intervertebral Disc Disease

Articles related to Intervertebral Disc Disease:

(show top 50) (show all 702)
# Title Authors PMID Year
1
A functional SNP in CILP, encoding cartilage intermediate layer protein, is associated with susceptibility to lumbar disc disease. 54 61 56 6
15864306 2005
2
An allele of COL9A2 associated with intervertebral disc disease. 54 61 56 6
10411504 1999
3
A functional polymorphism in THBS2 that affects alternative splicing and MMP binding is associated with lumbar-disc herniation. 56 6
18455130 2008
4
Association of the asporin D14 allele with lumbar-disc degeneration in Asians. 56 6
18304494 2008
5
A functional polymorphism in COL11A1, which encodes the alpha 1 chain of type XI collagen, is associated with susceptibility to lumbar disc herniation. 56 6
17999364 2007
6
Identification of a novel common genetic risk factor for lumbar disk disease. 56 6
11308397 2001
7
Phenotypic and population differences in the association between CILP and lumbar disc disease. 54 61 56
17220213 2007
8
Association between an aggrecan gene polymorphism and lumbar disc degeneration. 61 56
10626307 1999
9
Genetic influences on cervical and lumbar disc degeneration: a magnetic resonance imaging study in twins. 61 56
10025932 1999
10
Replication of the association of the aspartic acid repeat polymorphism in the asporin gene with knee-osteoarthritis susceptibility in Han Chinese. 6
17024313 2006
11
An aspartic acid repeat polymorphism in asporin inhibits chondrogenesis and increases susceptibility to osteoarthritis. 6
15640800 2005
12
Familial predisposition for lumbar degenerative disc disease. A case-control study. 56
9589542 1998
13
Similarities in degenerative findings on magnetic resonance images of the lumbar spines of identical twins. 56
7593075 1995
14
Six-year outcomes of anterior lumbar interbody arthrodesis with use of interbody fusion cages and recombinant human bone morphogenetic protein-2. 54 61
19411467 2009
15
[Association of single nucleotide polymorphisms of IL-1b with lumbar disc disease]. 54 61
17681918 2007
16
Intervertebral disc degeneration in relation to the COL9A3 and the IL-1ss gene polymorphisms. 54 61
16133074 2006
17
Transcriptional regulation of the cartilage intermediate layer protein (CILP) gene. 54 61
16413503 2006
18
Association study of COL9A2 with lumbar disc disease in the Japanese population. 54 61
17024315 2006
19
Association of a COL1A1 polymorphism with lumbar disc disease in young military recruits. 54 61
15994869 2005
20
The role of collagen IX tryptophan polymorphisms in symptomatic intervertebral disc disease in Southern European patients. 54 61
15167667 2004
21
Lumbar interbody fusion after treatment with recombinant human bone morphogenetic protein-2 added to poly(L-lactide-co-D,L-lactide) bioresorbable implants. 54 61
15198497 2004
22
Sequence variations in the collagen IX and XI genes are associated with degenerative lumbar spinal stenosis. 54 61
14644861 2003
23
COL9A2 allelotypes in intervertebral disc disease. 54 61
11118298 2000
24
Reduced nucleotomy-induced intervertebral disc disruption through spontaneous spheroid formation by the Low Adhesive Scaffold Collagen (LASCol). 61
31981764 2020
25
Butyrate alleviates inflammatory response and NF-κB activation in human degenerated intervertebral disc tissues. 61
31780370 2020
26
Degenerative lumbar disc disease: in vivo data support the rationale for the selection of appropriate animal models. 61
31904862 2020
27
DISEASE AND PATHOLOGICAL CONDITIONS OF AN ENDANGERED RODENT, MICROTUS CALIFORNICUS SCIRPENSIS, IN A CAPTIVE-REARING FACILITY AND IN THE WILD. 61
31926505 2020
28
Differential Effect of Long-Term Systemic Exposure of TNFα on Health of the Annulus Fibrosus and Nucleus Pulposus of the Intervertebral Disc. 61
31800975 2019
29
Functional Changes in Patients and Morphological Changes in the Lumbar Intervertebral Disc after Applying Lordotic Curve-Controlled Traction: A Double-Blind Randomized Controlled Study. 61
31861714 2019
30
The Long-term Reoperation Rate Following Surgery for Lumbar Herniated Intervertebral Disc Disease: A Nationwide Sample Cohort Study With a 10-year Follow-up. 61
30973508 2019
31
Is age more than manual material handling associated with lumbar vertebral body and disc changes? A cross-sectional multicentre MRI study. 61
31537567 2019
32
Long-term outcomes of lumbar microdiscectomy in the pediatric population: a large single-institution case series. 61
31470400 2019
33
[Experiments study on mechanical behavior of porcine lumbar intervertebral disc after nucleotomy under compression]. 61
31441259 2019
34
Inflammatory biomarkers in sera of patients with intervertebral disc degeneration. 61
31482941 2019
35
A Heterologous Fibrin Glue Enhances the Closure Effect of Surgical Suture on the Repair of Annulus Fibrous Defect in a Sheep Model. 61
31346996 2019
36
[Outcome of intervertebral disk disease surgery depending on dog breed, location and experience of the surgeon: 1113 cases]. 61
31434123 2019
37
Congenital block vertebrae and intervertebral disc protrusion in a young cat. 61
31448128 2019
38
Phenotypic Effects of FGF4 Retrogenes on Intervertebral Disc Disease in Dogs. 61
31181696 2019
39
Clinical reasoning in feline spinal disease: which combination of clinical information is useful? 61
31251096 2019
40
The Functional and Morphological Changes of the Cervical Intervertebral Disc after Applying Lordotic Curve Controlled Traction: A Double-Blind Randomized Controlled Study. 61
31248064 2019
41
Magnetic resonance image findings in pug dogs with thoracolumbar myelopathy and concurrent caudal articular process dysplasia. 61
31151444 2019
42
Multilevel Anterior Lumbar Interbody Fusion Combined with Posterior Stabilization in Lumbar Disc Disease-Prospective Analysis of Clinical and Functional Outcomes. 61
31363259 2019
43
Calcification of extruded intervertebral discs in dachshunds: a radiographic, computed tomographic and histopathological study of 25 cases. 61
30849997 2019
44
Effect of Targeted Pulsed Electromagnetic Field Therapy on Canine Postoperative Hemilaminectomy: A Double-Blind, Randomized, Placebo-Controlled Clinical Trial. 61
30776260 2019
45
Paraspinal muscle atrophy after posterior lumbar surgery with and without pedicle screw fixation with the classic technique. 61
30579798 2019
46
Does the presence of the fibronectin-aggrecan complex predict outcomes from lumbar discectomy for disc herniation? 61
24239034 2019
47
The effect of body condition on postoperative recovery of dachshunds with intervertebral disc disease treated with postoperative physical rehabilitation. 61
30549081 2019
48
Effectiveness of Percutaneous Intradiscal Decompression Therapy in Thoracic Disc Herniation 61
30299261 2019
49
Total sitting time, leisure time physical activity and risk of hospitalization due to low back pain: The Danish Health Examination Survey cohort 2007-2008. 61
29493433 2019
50
Behavioral Changes in Dogs With Idiopathic Epilepsy Compared to Other Medical Populations. 61
31781583 2019

Variations for Intervertebral Disc Disease

ClinVar genetic disease variations for Intervertebral Disc Disease:

6 ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 ASPN NM_001012267.3(CENPP):c.564+94884TCA[15]short repeat risk factor 2527 9:95237024-95237025 9:92474742-92474743
2 CILP NM_003613.4(CILP):c.1184T>C (p.Ile395Thr)SNV risk factor 6312 rs2073711 15:65494212-65494212 15:65201874-65201874
3 THBS2 NM_003247.3(THBS2):c.1478-8C>TSNV risk factor 12713 rs9406328 6:169635010-169635010 6:169234915-169234915
4 COL9A3 NM_001853.4(COL9A3):c.388G>A (p.Gly130Ser)SNV Uncertain significance 392918 rs139401633 20:61453127-61453127 20:62821775-62821775
5 COL9A3 NM_001853.4(COL9A3):c.505G>A (p.Ala169Thr)SNV Uncertain significance 387925 rs948698664 20:61453970-61453970 20:62822618-62822618
6 COL9A2 NM_001852.4(COL9A2):c.2059A>G (p.Lys687Glu)SNV Uncertain significance 417900 rs201847956 1:40766865-40766865 1:40301193-40301193
7 COL9A3 NM_001853.4(COL9A3):c.307C>T (p.Arg103Trp)SNV Benign/Likely benign 17139 rs61734651 20:61451332-61451332 20:62819980-62819980
8 COL9A2 NM_001852.4(COL9A2):c.976_977inv (p.Gln326Trp)inversion Benign 17145 rs137853213 1:40773149-40773150 1:40307477-40307478
9 COL11A1 NM_001854.4(COL11A1):c.4603T>C (p.Ser1535Pro)SNV Benign 17137 rs1676486 1:103354138-103354138 1:102888582-102888582

UniProtKB/Swiss-Prot genetic disease variations for Intervertebral Disc Disease:

73
# Symbol AA change Variation ID SNP ID
1 COL9A2 p.Gln326Trp VAR_012658 rs137853213

Expression for Intervertebral Disc Disease

Search GEO for disease gene expression data for Intervertebral Disc Disease.

Pathways for Intervertebral Disc Disease

Pathways related to Intervertebral Disc Disease according to GeneCards Suite gene sharing:

(show all 45)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.71 IL6 IL1B IL1A COL9A3 COL9A2 COL11A2
2
Show member pathways
12.97 IL6 COL9A3 COL9A2 COL11A2 COL11A1
3
Show member pathways
12.81 THBS2 COL9A3 COL9A2 COL11A2 COL11A1
4
Show member pathways
12.75 MMP9 COL9A3 COL9A2 COL11A2 COL11A1
5
Show member pathways
12.59 MMP9 COL9A3 COL9A2 COL11A2 COL11A1 ASPN
6
Show member pathways
12.52 IL6 IL1B IL1A IFNG
7
Show member pathways
12.51 IL6 IL1B IL1A IFNG
8
Show member pathways
12.25 MMP9 IL6 IL1B IFNG
9
Show member pathways
12.24 IL6 IL1B IL1A IFNG
10
Show member pathways
12.18 IL6 IL1B IL1A IFNG
11 12.08 IL6 IL1B IL1A
12
Show member pathways
12.06 THBS2 COL9A3 COL9A2
13 12.06 VDR IL6 IL1B IL1A IFNG
14 12.01 MMP9 IL1B IL1A IFNG
15
Show member pathways
11.97 IL6 IL1B IFNG
16 11.97 IL1B IL1A IFNG
17
Show member pathways
11.95 MMP9 IL6 IL1B IFNG
18 11.9 MMP9 IL6 IL1B
19 11.89 MMP9 IL6 IL1B IL1A
20 11.85 IL6 IL1B IFNG
21 11.84 IL6 IL1B IL1A IFNG
22 11.83 IL6 IL1B IL1A
23 11.83 IL6 IL1B IL1A
24 11.76 IL6 IL1B IL1A IFNG
25 11.73 MMP9 IL6 IL1B IL1A IFNG
26 11.71 IL6 IL1B IL1A
27 11.68 IL6 IL1B IFNG
28 11.68 IL6 IL1B IL1A IFNG
29 11.6 MMP9 IL6 IL1B
30 11.59 MMP9 IL6 IL1B IFNG
31 11.54 COL9A3 COL9A2 ASPN
32 11.47 IL6 IL1B IL1A
33 11.46 IL6 IL1B IL1A
34 11.37 THBS2 IL6 IL1B IFNG
35 11.34 IL6 IL1B IFNG
36 11.3 IL6 IL1B IL1A
37 11.3 IL6 IL1B IL1A
38 11.24 IL6 IL1B IFNG
39
Show member pathways
11.15 MMP9 IL6 IL1B IL1A IFNG
40 11.1 MMP9 IL1B IFNG
41 10.99 IL1A IFNG
42 10.92 IL6 IL1B IL1A IFNG
43 10.77 IL6 IL1B IL1A COL9A3 COL9A2 COL11A2
44 10.67 VDR IL6 IL1B IL1A IFNG
45 10.48 IL1B IL1A

GO Terms for Intervertebral Disc Disease

Cellular components related to Intervertebral Disc Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.96 MMP9 IL6 IL1B IL1A IFNG COL9A3
2 endoplasmic reticulum lumen GO:0005788 9.77 IL6 COL9A3 COL9A2 COL11A2 COL11A1
3 extracellular region GO:0005576 9.73 THBS2 MMP9 IL6 IL1B IL1A IFNG
4 extracellular matrix GO:0031012 9.7 THBS2 MMP9 COL9A3 COL9A2 COL11A2 COL11A1
5 collagen trimer GO:0005581 9.62 COL9A3 COL9A2 COL11A2 COL11A1
6 collagen type IX trimer GO:0005594 9.43 COL9A3 COL9A2
7 collagen type XI trimer GO:0005592 9.4 COL11A2 COL11A1
8 collagen-containing extracellular matrix GO:0062023 9.23 THBS2 MMP9 COL9A3 COL9A2 COL11A2 COL11A1

Biological processes related to Intervertebral Disc Disease according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.88 VDR IL6 IL1B IL1A
2 positive regulation of gene expression GO:0010628 9.8 VDR IL6 IL1B IL1A IFNG
3 cytokine-mediated signaling pathway GO:0019221 9.78 MMP9 IL6 IL1B IL1A
4 cellular response to lipopolysaccharide GO:0071222 9.67 VDR IL6 IL1B IL1A
5 positive regulation of interleukin-6 production GO:0032755 9.61 IL6 IL1B IL1A
6 positive regulation of glial cell proliferation GO:0060252 9.57 IL6 IL1B
7 astrocyte activation GO:0048143 9.56 IL1B IFNG
8 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.55 IL1B IFNG
9 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.54 IL1B IL1A
10 positive regulation of neuroinflammatory response GO:0150078 9.52 IL6 IL1B
11 positive regulation of chemokine biosynthetic process GO:0045080 9.51 IL1B IFNG
12 regulation of neuroinflammatory response GO:0150077 9.49 MMP9 IL6
13 ectopic germ cell programmed cell death GO:0035234 9.46 IL1B IL1A
14 skeletal system development GO:0001501 9.46 VDR MMP9 COL9A2 COL11A2
15 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.32 IL1B IFNG
16 fever generation GO:0001660 9.26 IL1B IL1A
17 positive regulation of vascular endothelial growth factor production GO:0010575 9.13 IL6 IL1B IL1A
18 extracellular matrix organization GO:0030198 9.02 MMP9 COL9A3 COL9A2 COL11A2 COL11A1

Molecular functions related to Intervertebral Disc Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.46 IL6 IL1B IL1A IFNG
2 interleukin-1 receptor binding GO:0005149 9.26 IL1B IL1A
3 extracellular matrix structural constituent conferring tensile strength GO:0030020 9.26 COL9A3 COL9A2 COL11A2 COL11A1
4 extracellular matrix structural constituent GO:0005201 9.1 THBS2 COL9A3 COL9A2 COL11A2 COL11A1 CILP

Sources for Intervertebral Disc Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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