MCID: INT253
MIFTS: 42

Intestinal Benign Neoplasm

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Intestinal Benign Neoplasm

MalaCards integrated aliases for Intestinal Benign Neoplasm:

Name: Intestinal Benign Neoplasm 12 15
Intestinal Neoplasms 44 73
Neoplasm of Intestinal Tract 12
Intestinal Tumors 12
Intestine Growth 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4610
MeSH 44 D007414
NCIt 50 C3141
SNOMED-CT 68 126769007
UMLS 73 C0021841

Summaries for Intestinal Benign Neoplasm

Disease Ontology : 12 A gastrointestinal system benign neoplasm that is located in the intestine.

MalaCards based summary : Intestinal Benign Neoplasm, also known as intestinal neoplasms, is related to small intestine cancer and polyposis syndrome, hereditary mixed, 1, and has symptoms including constipation and diarrhea. An important gene associated with Intestinal Benign Neoplasm is CTNNB1 (Catenin Beta 1), and among its related pathways/superpathways are fMLP Pathway and TCR Signaling (Qiagen). Affiliated tissues include the intestine and small intestine, and related phenotypes are cellular and homeostasis/metabolism

Related Diseases for Intestinal Benign Neoplasm

Diseases related to Intestinal Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 181)
# Related Disease Score Top Affiliating Genes
1 small intestine cancer 30.9 CCND1 CDX2 KRAS MLH1 MSH2 MUC2
2 polyposis syndrome, hereditary mixed, 1 29.9 APC MLH1 MUTYH PTGS2
3 colonic benign neoplasm 29.3 AREG CEACAM5 CTNNB1 HPGD KRAS LGR5
4 adenoma 27.1 APC CCND1 CTNNB1 KRAS MLH1 MSH2
5 familial adenomatous polyposis 26.7 APC CCND1 CDH1 CTNNB1 KRAS MLH1
6 gastric cancer 26.5 APC CCND1 CDH1 CDX2 CEACAM5 CTNNB1
7 large intestine adenoma 11.0
8 rectum adenoma 11.0
9 desmoid disease, hereditary 10.9 APC CTNNB1
10 rare adenocarcinoma of the breast 10.9 KRAS TP53
11 adult hepatocellular carcinoma 10.9 CTNNB1 TP53
12 periampullary adenoma 10.8 APC HRAS KRAS
13 familial adenomatous polyposis 1 10.8 APC CTNNB1
14 ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3 10.8 CTNNB1 KRAS TP53
15 protoplasmic astrocytoma 10.8 PTGS2 TP53
16 mixed cell type cancer 10.8 HRAS KRAS TP53
17 bladder adenocarcinoma 10.8 CDX2 CTNNB1 HRAS
18 barrett's adenocarcinoma 10.8 KRAS PTGS2 TP53
19 liver angiosarcoma 10.8 HRAS KRAS TP53
20 anal canal adenocarcinoma 10.8 CDX2 HRAS KRAS
21 skin squamous cell carcinoma 10.8 HRAS KRAS TP53
22 lung benign neoplasm 10.7 HRAS KRAS TP53
23 juvenile polyposis syndrome 10.7 APC MUTYH PTGS2
24 colon adenoma 10.7 APC KRAS LGR5
25 ureteral obstruction 10.7 CTNNB1 PTGS2 TP53
26 esophageal disease 10.7 CDX2 PTGS2 TP53
27 suppression of tumorigenicity 12 10.7 CTNNB1 HRAS TP53
28 peutz-jeghers syndrome 10.7 APC CTNNB1 TP53
29 anal squamous cell carcinoma 10.7 APC MLH1 TP53
30 cervical adenocarcinoma 10.6 CDX2 PTGS2 TP53
31 keratocystic odontogenic tumor 10.6 CCND1 PTGS2 TP53
32 appendix carcinoid tumor 10.6 MLH1 MSH2
33 adenosquamous colon carcinoma 10.6 MLH1 MSH2
34 attenuated familial adenomatous polyposis 10.6 APC MSH2 MUTYH
35 atypical teratoid rhabdoid tumor 10.6 CCND1 CTNNB1 TP53
36 endometrial adenocarcinoma 10.6 KRAS MLH1 TP53
37 penile cancer 10.6 CCND1 HRAS TP53
38 colloid carcinoma of the pancreas 10.6 HRAS KRAS MUC2
39 hyperplastic polyposis syndrome 10.6 APC KRAS MUTYH TP53
40 mutyh-associated polyposis 10.6 APC KRAS MUTYH TP53
41 mucinous intrahepatic cholangiocarcinoma 10.6 CDX2 MUC2
42 gastroesophageal reflux 10.5 CDX2 PTGS2 TP53
43 nasal cavity adenocarcinoma 10.5 CDX2 HRAS KRAS TP53
44 melanocytic nevus syndrome, congenital 10.5 HRAS MLH1 MSH2
45 mesenteric vascular occlusion 10.5 MTHFR ODC1
46 differentiated thyroid carcinoma 10.5 HRAS KRAS MTHFR TP53
47 appendix cancer 10.5 CDX2 KRAS MUC2
48 cystitis cystica 10.5 CDX2 CTNNB1 MUC2
49 hepatoblastoma 10.5 APC CTNNB1 TP53
50 gastric tubular adenocarcinoma 10.5 CDX2 MUC2 PTGS2

Graphical network of the top 20 diseases related to Intestinal Benign Neoplasm:



Diseases related to Intestinal Benign Neoplasm

Symptoms & Phenotypes for Intestinal Benign Neoplasm

UMLS symptoms related to Intestinal Benign Neoplasm:


constipation, diarrhea

MGI Mouse Phenotypes related to Intestinal Benign Neoplasm:

46 (show all 18)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.44 CDH1 CCND1 APC CTNNB1 KRAS HPGD
2 homeostasis/metabolism MP:0005376 10.42 CDH1 AREG CCND1 APC HRAS CTNNB1
3 mortality/aging MP:0010768 10.41 CDH1 AREG CCND1 APC CTNNB1 KRAS
4 digestive/alimentary MP:0005381 10.39 CDH1 AREG CDX2 CCND1 APC CTNNB1
5 endocrine/exocrine gland MP:0005379 10.37 CDH1 AREG CCND1 APC CTNNB1 KRAS
6 growth/size/body region MP:0005378 10.36 APC CDH1 AREG CCND1 HRAS CTNNB1
7 cardiovascular system MP:0005385 10.35 CDH1 AREG CCND1 APC HRAS CTNNB1
8 integument MP:0010771 10.29 CDH1 AREG CCND1 APC HRAS CTNNB1
9 neoplasm MP:0002006 10.28 CDH1 CDX2 CCND1 APC CTNNB1 KRAS
10 embryo MP:0005380 10.14 APC CDH1 CDX2 CTNNB1 KRAS TP53
11 craniofacial MP:0005382 10.1 CCND1 APC HRAS CTNNB1 LGR5 KRAS
12 normal MP:0002873 10.07 APC CDH1 CCND1 HRAS CTNNB1 CDX2
13 reproductive system MP:0005389 10.03 CDH1 AREG CCND1 APC CTNNB1 KRAS
14 no phenotypic analysis MP:0003012 10.01 APC CDH1 HRAS CTNNB1 MTHFR KRAS
15 renal/urinary system MP:0005367 9.87 APC HRAS CTNNB1 LGR5 KRAS TP53
16 respiratory system MP:0005388 9.76 CCND1 HRAS CTNNB1 LGR5 MLH1 KRAS
17 skeleton MP:0005390 9.61 CCND1 APC HRAS CTNNB1 CDX2 MTHFR
18 vision/eye MP:0005391 9.28 CCND1 APC AREG CTNNB1 MTHFR MLH1

Drugs & Therapeutics for Intestinal Benign Neoplasm

Search Clinical Trials , NIH Clinical Center for Intestinal Benign Neoplasm

Cochrane evidence based reviews: intestinal neoplasms

Genetic Tests for Intestinal Benign Neoplasm

Anatomical Context for Intestinal Benign Neoplasm

The Foundational Model of Anatomy Ontology organs/tissues related to Intestinal Benign Neoplasm:

19
The Intestine

MalaCards organs/tissues related to Intestinal Benign Neoplasm:

41
Small Intestine

Publications for Intestinal Benign Neoplasm

Articles related to Intestinal Benign Neoplasm:

# Title Authors Year
1
TGF-beta receptor inactivation and mutant Kras induce intestinal neoplasms in mice via a beta-catenin-independent pathway. ( 19208363 )
2009
2
Transforming growth factor beta receptor type II inactivation induces the malignant transformation of intestinal neoplasms initiated by Apc mutation. ( 17047044 )
2006
3
Intestinal neoplasm mimicking a Meckel's diverticulum on scintigraphic imaging. ( 1646093 )
1991
4
Three cases of small intestinal neoplasm. ( 13083804 )
1953
5
Three cases of small-intestinal neoplasm with unusual clinical features. ( 13059482 )
1953

Variations for Intestinal Benign Neoplasm

Expression for Intestinal Benign Neoplasm

Search GEO for disease gene expression data for Intestinal Benign Neoplasm.

Pathways for Intestinal Benign Neoplasm

Pathways related to Intestinal Benign Neoplasm according to GeneCards Suite gene sharing:

(show top 50) (show all 55)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.02 CDH1 CDX2 CTNNB1 HRAS KRAS TP53
2
Show member pathways
12.93 HRAS KRAS MLH1 MSH2 PTGS2 TP53
3
Show member pathways
12.92 APC AREG CCND1 CTNNB1 HRAS KRAS
4
Show member pathways
12.77 CCND1 CDH1 HRAS KRAS TP53
5
Show member pathways
12.7 APC AREG CCND1 CDH1 CTNNB1 HRAS
6
Show member pathways
12.68 APC CDH1 CTNNB1 HRAS KRAS PTGS2
7
Show member pathways
12.59 CTNNB1 HRAS KRAS MSH2 TP53
8 12.58 APC CCND1 CDH1 CTNNB1 HRAS KRAS
9
Show member pathways
12.57 CCND1 CTNNB1 HRAS KRAS PTGS2 TP53
10 12.51 APC CCND1 HRAS KRAS PTGS2 TP53
11 12.5 CCND1 MLH1 MSH2 MUTYH TP53
12
Show member pathways
12.49 APC HRAS KRAS LGR5 TP53
13
Show member pathways
12.49 AREG CCND1 CDH1 CTNNB1 HRAS KRAS
14
Show member pathways
12.46 AREG CCND1 HRAS KRAS TP53
15
Show member pathways
12.44 CTNNB1 HRAS KRAS TP53
16
Show member pathways
12.42 CCND1 CTNNB1 HRAS KRAS
17 12.42 APC CCND1 CTNNB1 HRAS KRAS TP53
18
Show member pathways
12.4 CTNNB1 HRAS KRAS PTGS2
19 12.37 APC CCND1 CDH1 TP53
20
Show member pathways
12.32 APC CCND1 CDH1 CDX2 CTNNB1 HRAS
21 12.3 CCND1 CTNNB1 HRAS KRAS TP53
22 12.29 CCND1 HRAS KRAS TP53
23
Show member pathways
12.26 APC CDH1 CTNNB1 HRAS
24 12.17 CCND1 HRAS KRAS TP53
25 12.15 CCND1 HRAS KRAS TP53
26 12.15 APC AREG CCND1 CDH1 CTNNB1
27
Show member pathways
12.13 APC CTNNB1 LGR5 TP53
28 12.09 APC CTNNB1 HRAS KRAS
29 12.08 CCND1 CDH1 HRAS KRAS
30 12.06 APC MLH1 MSH2 TP53
31 12.05 CCND1 CDH1 CTNNB1 KRAS MSH2 ODC1
32 12.04 APC CDH1 CTNNB1 HRAS KRAS
33
Show member pathways
11.99 APC CCND1 CDH1 CTNNB1 PTGS2 TP53
34 11.99 CCND1 CTNNB1 HRAS KRAS TP53
35 11.94 APC CCND1 CTNNB1 HRAS KRAS TP53
36 11.89 APC CCND1 CTNNB1 HRAS KRAS TP53
37 11.86 CCND1 PTGS2 TP53
38 11.79 APC CCND1 CDH1 CTNNB1
39 11.74 MLH1 MSH2 TP53
40 11.69 CCND1 CDH1 HRAS KRAS TP53
41 11.68 HRAS KRAS TP53
42 11.68 HRAS KRAS TP53
43 11.59 APC CCND1 TP53
44 11.58 APC CCND1 CTNNB1
45 11.56 CCND1 PTGS2 TP53
46 11.53 HRAS KRAS PTGS2
47 11.5 APC CCND1 CTNNB1
48 11.49 APC CCND1 CDH1 CTNNB1 KRAS MLH1
49
Show member pathways
11.43 MLH1 MSH2 TP53
50 11.32 CCND1 CDH1 CTNNB1

GO Terms for Intestinal Benign Neoplasm

Cellular components related to Intestinal Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 beta-catenin destruction complex GO:0030877 9.32 APC CTNNB1
2 Wnt signalosome GO:1990909 9.26 APC CTNNB1
3 flotillin complex GO:0016600 9.16 CDH1 CTNNB1
4 lateral plasma membrane GO:0016328 9.13 APC CDH1 CTNNB1
5 catenin complex GO:0016342 8.8 APC CDH1 CTNNB1

Biological processes related to Intestinal Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.97 APC CTNNB1 HRAS PTGS2 TP53
2 cell proliferation GO:0008283 9.93 APC AREG CTNNB1 HRAS TP53
3 positive regulation of apoptotic process GO:0043065 9.88 APC CTNNB1 HPGD PTGS2 TP53
4 cellular response to DNA damage stimulus GO:0006974 9.85 APC CCND1 MLH1 MSH2 MUTYH TP53
5 response to drug GO:0042493 9.83 CCND1 CDH1 CTNNB1 MTHFR PTGS2
6 canonical Wnt signaling pathway GO:0060070 9.78 APC CCND1 CTNNB1
7 Ras protein signal transduction GO:0007265 9.77 HRAS KRAS TP53
8 cell cycle arrest GO:0007050 9.76 APC HRAS MSH2 TP53
9 epidermal growth factor receptor signaling pathway GO:0007173 9.73 AREG HRAS KRAS
10 determination of adult lifespan GO:0008340 9.61 MSH2 TP53
11 entry of bacterium into host cell GO:0035635 9.6 CDH1 CTNNB1
12 mitotic G1 DNA damage checkpoint GO:0031571 9.58 CCND1 TP53
13 positive regulation of isotype switching to IgG isotypes GO:0048304 9.58 MLH1 MSH2
14 mismatch repair GO:0006298 9.58 MLH1 MSH2 MUTYH
15 response to isolation stress GO:0035900 9.55 HRAS KRAS
16 cellular response to indole-3-methanol GO:0071681 9.52 CDH1 CTNNB1
17 positive regulation of isotype switching to IgA isotypes GO:0048298 9.51 MLH1 MSH2
18 somatic recombination of immunoglobulin gene segments GO:0016447 9.49 MLH1 MSH2
19 response to glucocorticoid GO:0051384 9.46 AREG CCND1 KRAS PTGS2
20 response to X-ray GO:0010165 9.43 CCND1 MSH2 TP53
21 response to estradiol GO:0032355 9.35 AREG CCND1 CTNNB1 HPGD PTGS2
22 somatic recombination of immunoglobulin genes involved in immune response GO:0002204 9.32 MLH1 MSH2
23 positive regulation of cell proliferation GO:0008284 9.23 AREG CCND1 CDX2 CTNNB1 HRAS KRAS

Molecular functions related to Intestinal Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein homodimerization activity GO:0042803 9.91 CDH1 CEACAM5 HPGD MSH2 ODC1 PTGS2
2 protein kinase binding GO:0019901 9.77 APC CCND1 CTNNB1 MSH2 TP53
3 enzyme binding GO:0019899 9.55 CCND1 CTNNB1 MSH2 PTGS2 TP53
4 mismatched DNA binding GO:0030983 9.46 MLH1 MSH2
5 gamma-catenin binding GO:0045295 9.4 APC CDH1
6 oxidized purine DNA binding GO:0032357 9.32 MSH2 MUTYH
7 MutLalpha complex binding GO:0032405 9.26 MSH2 MUTYH
8 MutSalpha complex binding GO:0032407 8.96 MLH1 MUTYH
9 guanine/thymine mispair binding GO:0032137 8.62 MLH1 MSH2

Sources for Intestinal Benign Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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