Intestinal Benign Neoplasm disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: INT253 MIFTS: 42	Intestinal Benign Neoplasm Categories: Cancer diseases, Gastrointestinal diseases
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Aliases & Classifications for Intestinal Benign Neoplasm

MalaCards integrated aliases for Intestinal Benign Neoplasm:

Name: Intestinal Benign Neoplasm ¹² ¹⁵

Intestinal Neoplasms ⁴⁴ ⁷³

Neoplasm of Intestinal Tract ¹²

Intestinal Tumors ¹²

Intestine Growth ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Gastrointestinal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:4610

MeSH ⁴⁴ D007414

NCIt ⁵⁰ C3141

SNOMED-CT ⁶⁸ 126769007

UMLS ⁷³ C0021841

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Summaries for Intestinal Benign Neoplasm

Disease Ontology : ¹² A gastrointestinal system benign neoplasm that is located in the intestine.

MalaCards based summary : Intestinal Benign Neoplasm, also known as intestinal neoplasms, is related to small intestine cancer and polyposis syndrome, hereditary mixed, 1, and has symptoms including constipation and diarrhea. An important gene associated with Intestinal Benign Neoplasm is CTNNB1 (Catenin Beta 1), and among its related pathways/superpathways are fMLP Pathway and TCR Signaling (Qiagen). Affiliated tissues include the intestine and small intestine, and related phenotypes are cellular and homeostasis/metabolism

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Related Diseases for Intestinal Benign Neoplasm

Diseases related to Intestinal Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 181)

#	Related Disease	Score	Top Affiliating Genes
1	small intestine cancer	30.9	CCND1 CDX2 KRAS MLH1 MSH2 MUC2
2	polyposis syndrome, hereditary mixed, 1	29.9	APC MLH1 MUTYH PTGS2
3	colonic benign neoplasm	29.3	AREG CEACAM5 CTNNB1 HPGD KRAS LGR5
4	adenoma	27.1	APC CCND1 CTNNB1 KRAS MLH1 MSH2
5	familial adenomatous polyposis	26.7	APC CCND1 CDH1 CTNNB1 KRAS MLH1
6	gastric cancer	26.5	APC CCND1 CDH1 CDX2 CEACAM5 CTNNB1
7	large intestine adenoma	11.0
8	rectum adenoma	11.0
9	desmoid disease, hereditary	10.9	APC CTNNB1
10	rare adenocarcinoma of the breast	10.9	KRAS TP53
11	adult hepatocellular carcinoma	10.9	CTNNB1 TP53
12	periampullary adenoma	10.8	APC HRAS KRAS
13	familial adenomatous polyposis 1	10.8	APC CTNNB1
14	ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3	10.8	CTNNB1 KRAS TP53
15	protoplasmic astrocytoma	10.8	PTGS2 TP53
16	mixed cell type cancer	10.8	HRAS KRAS TP53
17	bladder adenocarcinoma	10.8	CDX2 CTNNB1 HRAS
18	barrett's adenocarcinoma	10.8	KRAS PTGS2 TP53
19	liver angiosarcoma	10.8	HRAS KRAS TP53
20	anal canal adenocarcinoma	10.8	CDX2 HRAS KRAS
21	skin squamous cell carcinoma	10.8	HRAS KRAS TP53
22	lung benign neoplasm	10.7	HRAS KRAS TP53
23	juvenile polyposis syndrome	10.7	APC MUTYH PTGS2
24	colon adenoma	10.7	APC KRAS LGR5
25	ureteral obstruction	10.7	CTNNB1 PTGS2 TP53
26	esophageal disease	10.7	CDX2 PTGS2 TP53
27	suppression of tumorigenicity 12	10.7	CTNNB1 HRAS TP53
28	peutz-jeghers syndrome	10.7	APC CTNNB1 TP53
29	anal squamous cell carcinoma	10.7	APC MLH1 TP53
30	cervical adenocarcinoma	10.6	CDX2 PTGS2 TP53
31	keratocystic odontogenic tumor	10.6	CCND1 PTGS2 TP53
32	appendix carcinoid tumor	10.6	MLH1 MSH2
33	adenosquamous colon carcinoma	10.6	MLH1 MSH2
34	attenuated familial adenomatous polyposis	10.6	APC MSH2 MUTYH
35	atypical teratoid rhabdoid tumor	10.6	CCND1 CTNNB1 TP53
36	endometrial adenocarcinoma	10.6	KRAS MLH1 TP53
37	penile cancer	10.6	CCND1 HRAS TP53
38	colloid carcinoma of the pancreas	10.6	HRAS KRAS MUC2
39	hyperplastic polyposis syndrome	10.6	APC KRAS MUTYH TP53
40	mutyh-associated polyposis	10.6	APC KRAS MUTYH TP53
41	mucinous intrahepatic cholangiocarcinoma	10.6	CDX2 MUC2
42	gastroesophageal reflux	10.5	CDX2 PTGS2 TP53
43	nasal cavity adenocarcinoma	10.5	CDX2 HRAS KRAS TP53
44	melanocytic nevus syndrome, congenital	10.5	HRAS MLH1 MSH2
45	mesenteric vascular occlusion	10.5	MTHFR ODC1
46	differentiated thyroid carcinoma	10.5	HRAS KRAS MTHFR TP53
47	appendix cancer	10.5	CDX2 KRAS MUC2
48	cystitis cystica	10.5	CDX2 CTNNB1 MUC2
49	hepatoblastoma	10.5	APC CTNNB1 TP53
50	gastric tubular adenocarcinoma	10.5	CDX2 MUC2 PTGS2

Graphical network of the top 20 diseases related to Intestinal Benign Neoplasm:

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Symptoms & Phenotypes for Intestinal Benign Neoplasm

UMLS symptoms related to Intestinal Benign Neoplasm:

constipation, diarrhea

MGI Mouse Phenotypes related to Intestinal Benign Neoplasm:

⁴⁶ (show all 18)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cellular	MP:0005384	10.44	CDH1 CCND1 APC CTNNB1 KRAS HPGD
2	homeostasis/metabolism	MP:0005376	10.42	CDH1 AREG CCND1 APC HRAS CTNNB1
3	mortality/aging	MP:0010768	10.41	CDH1 AREG CCND1 APC CTNNB1 KRAS
4	digestive/alimentary	MP:0005381	10.39	CDH1 AREG CDX2 CCND1 APC CTNNB1
5	endocrine/exocrine gland	MP:0005379	10.37	CDH1 AREG CCND1 APC CTNNB1 KRAS
6	growth/size/body region	MP:0005378	10.36	APC CDH1 AREG CCND1 HRAS CTNNB1
7	cardiovascular system	MP:0005385	10.35	CDH1 AREG CCND1 APC HRAS CTNNB1
8	integument	MP:0010771	10.29	CDH1 AREG CCND1 APC HRAS CTNNB1
9	neoplasm	MP:0002006	10.28	CDH1 CDX2 CCND1 APC CTNNB1 KRAS
10	embryo	MP:0005380	10.14	APC CDH1 CDX2 CTNNB1 KRAS TP53
11	craniofacial	MP:0005382	10.1	CCND1 APC HRAS CTNNB1 LGR5 KRAS
12	normal	MP:0002873	10.07	APC CDH1 CCND1 HRAS CTNNB1 CDX2
13	reproductive system	MP:0005389	10.03	CDH1 AREG CCND1 APC CTNNB1 KRAS
14	no phenotypic analysis	MP:0003012	10.01	APC CDH1 HRAS CTNNB1 MTHFR KRAS
15	renal/urinary system	MP:0005367	9.87	APC HRAS CTNNB1 LGR5 KRAS TP53
16	respiratory system	MP:0005388	9.76	CCND1 HRAS CTNNB1 LGR5 MLH1 KRAS
17	skeleton	MP:0005390	9.61	CCND1 APC HRAS CTNNB1 CDX2 MTHFR
18	vision/eye	MP:0005391	9.28	CCND1 APC AREG CTNNB1 MTHFR MLH1

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Drugs & Therapeutics for Intestinal Benign Neoplasm

Search Clinical Trials , NIH Clinical Center for Intestinal Benign Neoplasm

Cochrane evidence based reviews: intestinal neoplasms

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Genetic Tests for Intestinal Benign Neoplasm

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Anatomical Context for Intestinal Benign Neoplasm

The Foundational Model of Anatomy Ontology organs/tissues related to Intestinal Benign Neoplasm:

¹⁹

The Intestine

MalaCards organs/tissues related to Intestinal Benign Neoplasm:

⁴¹

Small Intestine

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Publications for Intestinal Benign Neoplasm

Articles related to Intestinal Benign Neoplasm:

#	Title	Authors	Year
1	TGF-beta receptor inactivation and mutant Kras induce intestinal neoplasms in mice via a beta-catenin-independent pathway. ( 19208363 )	Trobridge P....Grady W.M.	2009
2	Transforming growth factor beta receptor type II inactivation induces the malignant transformation of intestinal neoplasms initiated by Apc mutation. ( 17047044 )	MuA+oz N.M....Grady W.M.	2006
3	Intestinal neoplasm mimicking a Meckel's diverticulum on scintigraphic imaging. ( 1646093 )	Mehall C.J....Davis L.P.	1991
4	Three cases of small intestinal neoplasm. ( 13083804 )	RECHNITZER P.	1953
5	Three cases of small-intestinal neoplasm with unusual clinical features. ( 13059482 )	RECHNITZER P.A....Blake J.	1953

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Genes for Intestinal Benign Neoplasm

Genes related to Intestinal Benign Neoplasm (0 elite genes):

(show all 21)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	CTNNB1	Catenin Beta 1	Protein Coding	16.9	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
2	PTGS2	Prostaglandin-Endoperoxide Synthase 2	Protein Coding	16.38	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
3	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	16.22	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
4	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	16	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
5	MUTYH	MutY DNA Glycosylase	Protein Coding	15.94	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
6	APC	APC, WNT Signaling Pathway Regulator	Protein Coding	15.92	Novoseek inferred ⁵⁵ GeneCards inferred via : Novoseek inferred (show sections)	12460911 17047044
7	TP53	Tumor Protein P53	Protein Coding	15.86	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
8	LGR5	Leucine Rich Repeat Containing G Protein-Coupled Receptor 5	Protein Coding	15.81	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
9	MTHFR	Methylenetetrahydrofolate Reductase	Protein Coding	15.72	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
10	CDX2	Caudal Type Homeobox 2	Protein Coding	15.46	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
11	MLH1	MutL Homolog 1	Protein Coding	15.43	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
12	HPGD	15-Hydroxyprostaglandin Dehydrogenase	Protein Coding	15.26	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
13	CCND1	Cyclin D1	Protein Coding	15.24	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
14	ODC1	Ornithine Decarboxylase 1	Protein Coding	15.16	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
15	MSH2	MutS Homolog 2	Protein Coding	15.05	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
16	MUC2	Mucin 2, Oligomeric Mucus/Gel-Forming	Protein Coding	15.04	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
17	KRTAP5-4	Keratin Associated Protein 5-4	Protein Coding	15.03	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
18	CDH1	Cadherin 1	Protein Coding	15	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
19	AREG	Amphiregulin	Protein Coding	6.93	DISEASES inferred ¹⁵ ¹⁵
20	CEACAM5	Carcinoembryonic Antigen Related Cell Adhesion Molecule 5	Protein Coding	5.84	DISEASES inferred ¹⁵
21	OR1B1	Olfactory Receptor Family 1 Subfamily B Member 1 (Gene/Pseudogene)	Protein Coding	5	DISEASES inferred ¹⁵

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Variations for Intestinal Benign Neoplasm

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Expression for Intestinal Benign Neoplasm

Search GEO for disease gene expression data for Intestinal Benign Neoplasm.

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Pathways for Intestinal Benign Neoplasm

Pathways related to Intestinal Benign Neoplasm according to GeneCards Suite gene sharing:

(show top 50) (show all 55)

#	Super pathways	Score	Top Affiliating Genes
1	fMLP Pathway ⁶⁴ Show member pathways Alpha-Adrenergic Signaling ⁶⁴ CCR3 Pathway in Eosinophils ⁶⁴ CXCR4 Pathway ⁶⁴ Huntington's Disease Pathway ⁶⁴ Internalin Pathway ⁶⁴ Signal transduction Activation of PKC via G-Protein coupled receptor ²² VEGF and S-1P Signaling ⁶⁴	13.02	CDH1 CDX2 CTNNB1 HRAS KRAS TP53
2	TCR Signaling (Qiagen) ⁶⁴ Show member pathways Fc-EpsilonRI Pathway ⁶⁴ PDGF Pathway ⁶⁴ PKC-Theta Pathway ⁶⁴ TCR Signaling ⁶⁴	12.93	HRAS KRAS MLH1 MSH2 PTGS2 TP53
3	PI3K-Akt signaling pathway ³⁷ Show member pathways Human papillomavirus infection ³⁷	12.92	APC AREG CCND1 CTNNB1 HRAS KRAS
4	Glioma ³⁷ Show member pathways EGFR tyrosine kinase inhibitor resistance ³⁷ Endocrine resistance ³⁷ Melanoma ³⁷ Non-small cell lung cancer ³⁷ Signaling Pathways in Glioblastoma ¹	12.77	CCND1 CDH1 HRAS KRAS TP53
5	Endometrial cancer ³⁷ Show member pathways Acute myeloid leukemia ³⁷ Binding of TCF/LEF-CTNNB1 to target gene promoters ⁶⁶ Chronic myeloid leukemia ³⁷ Colorectal cancer ³⁷ Pancreatic cancer ³⁷ Prostate cancer ³⁷ Signal transduction PTEN pathway ²² Thyroid cancer ³⁷	12.7	APC AREG CCND1 CDH1 CTNNB1 HRAS
6	Development HGF signaling pathway ²² Show member pathways Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1 ²² Apoptosis and survival NGF signaling pathway ²² Apoptosis and survival Role of CDK5 in neuronal death and survival ²² Development Neurotrophin family signaling ²² MET activates PTPN11 ⁶⁶ MET activates STAT3 ⁶⁶ Neurotrophin signaling pathway ³⁷ Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) ¹ Signaling of Hepatocyte Growth Factor Receptor ¹	12.68	APC CDH1 CTNNB1 HRAS KRAS PTGS2
7	Immune response IL-23 signaling pathway ²² Show member pathways Angiopoietin receptor Tie2-mediated signaling ¹ Angiopoietin-TIE2 Signaling ⁶⁴ Development Angiopoietin - Tie2 signaling ²² Development PDGF signaling via STATs and NF-kB ²² IL23-mediated signaling events ¹ Immune response IL-10 signaling pathway ²² Rac1/Pak1/p38/MMP-2 pathway ¹	12.59	CTNNB1 HRAS KRAS MSH2 TP53
8	Pathways in cancer ³⁷	12.58	APC CCND1 CDH1 CTNNB1 HRAS KRAS
9	Kaposi's sarcoma-associated herpesvirus infection ³⁷ Show member pathways Hepatitis B ³⁷	12.57	CCND1 CTNNB1 HRAS KRAS PTGS2 TP53
10	MicroRNAs in cancer ³⁷	12.51	APC CCND1 HRAS KRAS PTGS2 TP53
11	DNA Damage ⁴	12.5	CCND1 MLH1 MSH2 MUTYH TP53
12	mTOR signaling pathway (KEGG) ⁶⁵ Show member pathways mTOR signaling pathway ³⁷	12.49	APC HRAS KRAS LGR5 TP53
13	Development EGFR signaling pathway ²² Show member pathways Development ERBB-family signaling ²² EGF Pathway ⁶⁴ EGFR Signaling Pathway ⁶⁷ ErbB receptor signaling network ¹	12.49	AREG CCND1 CDH1 CTNNB1 HRAS KRAS
14	ErbB signaling pathway ¹ ³⁷ Show member pathways EGFR Inhibitor Pathway, Pharmacodynamics ⁶¹ Renal cell carcinoma ³⁷ TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer ¹	12.46	AREG CCND1 HRAS KRAS TP53
15	Apoptosis Pathway ⁷² Show member pathways Akt Pathway ⁷² NF-kappaB Pathway ⁷²	12.44	CTNNB1 HRAS KRAS TP53
16	Arrhythmogenic right ventricular cardiomyopathy (ARVC) ³⁷ Show member pathways Arrhythmogenic Right Ventricular Cardiomyopathy ¹ Calpain Protease Regulates Cellular Mechanics ⁶⁴	12.42	CCND1 CTNNB1 HRAS KRAS
17	HTLV-I infection ³⁷	12.42	APC CCND1 CTNNB1 HRAS KRAS TP53
18	Development VEGF signaling via VEGFR2 - generic cascades ²² Show member pathways Development VEGF signaling and activation ²² VEGF - VEGF R2 Signaling Pathways ⁶⁵	12.4	CTNNB1 HRAS KRAS PTGS2
19	Cell cycle ¹ ³⁷	12.37	APC CCND1 CDH1 TP53
20	Gastric cancer ³⁷ Show member pathways Breast cancer ³⁷ Hepatocellular carcinoma ³⁷	12.32	APC CCND1 CDH1 CDX2 CTNNB1 HRAS
21	Proteoglycans in cancer ³⁷	12.3	CCND1 CTNNB1 HRAS KRAS TP53
22	Viral carcinogenesis ³⁷	12.29	CCND1 HRAS KRAS TP53
23	G-protein signaling RAC1 in cellular process ²² Show member pathways CDC42 signaling events ¹ Cytoskeleton remodeling CDC42 in cellular processes ²² RAC1 signaling pathway ¹	12.26	APC CDH1 CTNNB1 HRAS
24	Cellular senescence (KEGG) ³⁷	12.17	CCND1 HRAS KRAS TP53
25	AKT Signaling Pathway ⁶⁷	12.15	CCND1 HRAS KRAS TP53
26	Hippo signaling pathway ³⁷	12.15	APC AREG CCND1 CDH1 CTNNB1
27	Wnt Signaling Pathways: beta-Catenin-dependent Wnt Signaling ⁶⁵ Show member pathways Basal cell carcinoma ³⁷	12.13	APC CTNNB1 LGR5 TP53
28	Signaling pathways regulating pluripotency of stem cells ³⁷	12.09	APC CTNNB1 HRAS KRAS
29	Apelin signaling pathway ³⁷	12.08	CCND1 CDH1 HRAS KRAS
30	Direct p53 effectors ¹	12.06	APC MLH1 MSH2 TP53
31	Integrated Breast Cancer Pathway ¹	12.05	CCND1 CDH1 CTNNB1 KRAS MSH2 ODC1
32	G12-G13 in Cellular Signaling ⁶⁴	12.04	APC CDH1 CTNNB1 HRAS KRAS
33	Cell cycle Cell cycle (generic schema) ²² Show member pathways Cell cycle Regulation of G1/S transition (part 2) ²² G0 and Early G1 ⁶⁶ G2 Phase ⁶⁶	11.99	APC CCND1 CDH1 CTNNB1 PTGS2 TP53
34	Thyroid hormone signaling pathway ³⁷	11.99	CCND1 CTNNB1 HRAS KRAS TP53
35	DNA Damage Response (only ATM dependent) ¹	11.94	APC CCND1 CTNNB1 HRAS KRAS TP53
36	Glioblastoma Multiforme ⁶⁴	11.89	APC CCND1 CTNNB1 HRAS KRAS TP53
37	Small cell lung cancer ³⁷	11.86	CCND1 PTGS2 TP53
38	Regulation of Wnt-mediated beta catenin signaling and target gene transcription ¹	11.79	APC CCND1 CDH1 CTNNB1
39	Platinum drug resistance ³⁷	11.74	MLH1 MSH2 TP53
40	Bladder cancer ³⁷ ¹	11.69	CCND1 CDH1 HRAS KRAS TP53
41	Central carbon metabolism in cancer ³⁷	11.68	HRAS KRAS TP53
42	Mitophagy - animal ³⁷	11.68	HRAS KRAS TP53
43	Copper homeostasis ¹	11.59	APC CCND1 TP53
44	Wnt Signaling Pathway Netpath ¹	11.58	APC CCND1 CTNNB1
45	Hepatitis C and Hepatocellular Carcinoma ¹	11.56	CCND1 PTGS2 TP53
46	Aryl Hydrocarbon Receptor ¹	11.53	HRAS KRAS PTGS2
47	Presenilin action in Notch and Wnt signaling ¹	11.5	APC CCND1 CTNNB1
48	Colorectal Cancer Metastasis ⁶⁴	11.49	APC CCND1 CDH1 CTNNB1 KRAS MLH1
49	Doxorubicin Pathway, Pharmacokinetics ⁶¹ Show member pathways Doxorubicin Pathway (Cancer Cell), Pharmacodynamics ⁶¹	11.43	MLH1 MSH2 TP53
50	E-cadherin signaling in the nascent adherens junction ¹	11.32	CCND1 CDH1 CTNNB1

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GO Terms for Intestinal Benign Neoplasm

Cellular components related to Intestinal Benign Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	beta-catenin destruction complex	GO:0030877	9.32	APC CTNNB1
2	Wnt signalosome	GO:1990909	9.26	APC CTNNB1
3	flotillin complex	GO:0016600	9.16	CDH1 CTNNB1
4	lateral plasma membrane	GO:0016328	9.13	APC CDH1 CTNNB1
5	catenin complex	GO:0016342	8.8	APC CDH1 CTNNB1

Biological processes related to Intestinal Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 23)

#	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of cell proliferation	GO:0008285	9.97	APC CTNNB1 HRAS PTGS2 TP53
2	cell proliferation	GO:0008283	9.93	APC AREG CTNNB1 HRAS TP53
3	positive regulation of apoptotic process	GO:0043065	9.88	APC CTNNB1 HPGD PTGS2 TP53
4	cellular response to DNA damage stimulus	GO:0006974	9.85	APC CCND1 MLH1 MSH2 MUTYH TP53
5	response to drug	GO:0042493	9.83	CCND1 CDH1 CTNNB1 MTHFR PTGS2
6	canonical Wnt signaling pathway	GO:0060070	9.78	APC CCND1 CTNNB1
7	Ras protein signal transduction	GO:0007265	9.77	HRAS KRAS TP53
8	cell cycle arrest	GO:0007050	9.76	APC HRAS MSH2 TP53
9	epidermal growth factor receptor signaling pathway	GO:0007173	9.73	AREG HRAS KRAS
10	determination of adult lifespan	GO:0008340	9.61	MSH2 TP53
11	entry of bacterium into host cell	GO:0035635	9.6	CDH1 CTNNB1
12	mitotic G1 DNA damage checkpoint	GO:0031571	9.58	CCND1 TP53
13	positive regulation of isotype switching to IgG isotypes	GO:0048304	9.58	MLH1 MSH2
14	mismatch repair	GO:0006298	9.58	MLH1 MSH2 MUTYH
15	response to isolation stress	GO:0035900	9.55	HRAS KRAS
16	cellular response to indole-3-methanol	GO:0071681	9.52	CDH1 CTNNB1
17	positive regulation of isotype switching to IgA isotypes	GO:0048298	9.51	MLH1 MSH2
18	somatic recombination of immunoglobulin gene segments	GO:0016447	9.49	MLH1 MSH2
19	response to glucocorticoid	GO:0051384	9.46	AREG CCND1 KRAS PTGS2
20	response to X-ray	GO:0010165	9.43	CCND1 MSH2 TP53
21	response to estradiol	GO:0032355	9.35	AREG CCND1 CTNNB1 HPGD PTGS2
22	somatic recombination of immunoglobulin genes involved in immune response	GO:0002204	9.32	MLH1 MSH2
23	positive regulation of cell proliferation	GO:0008284	9.23	AREG CCND1 CDX2 CTNNB1 HRAS KRAS

Molecular functions related to Intestinal Benign Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protein homodimerization activity	GO:0042803	9.91	CDH1 CEACAM5 HPGD MSH2 ODC1 PTGS2
2	protein kinase binding	GO:0019901	9.77	APC CCND1 CTNNB1 MSH2 TP53
3	enzyme binding	GO:0019899	9.55	CCND1 CTNNB1 MSH2 PTGS2 TP53
4	mismatched DNA binding	GO:0030983	9.46	MLH1 MSH2
5	gamma-catenin binding	GO:0045295	9.4	APC CDH1
6	oxidized purine DNA binding	GO:0032357	9.32	MSH2 MUTYH
7	MutLalpha complex binding	GO:0032405	9.26	MSH2 MUTYH
8	MutSalpha complex binding	GO:0032407	8.96	MLH1 MUTYH
9	guanine/thymine mispair binding	GO:0032137	8.62	MLH1 MSH2

Sources

Sources for Intestinal Benign Neoplasm

¹ BioSystems

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⁷⁶ Wikipedia