MCID: INT253
MIFTS: 51

Intestinal Benign Neoplasm

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Intestinal Benign Neoplasm

MalaCards integrated aliases for Intestinal Benign Neoplasm:

Name: Intestinal Benign Neoplasm 12 15
Intestinal Neoplasms 44 73
Neoplasm of Intestinal Tract 12
Intestinal Tumors 12
Intestine Growth 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4610
MeSH 44 D007414
NCIt 50 C3141
UMLS 73 C0021841

Summaries for Intestinal Benign Neoplasm

Disease Ontology : 12 A gastrointestinal system benign neoplasm that is located in the intestine.

MalaCards based summary : Intestinal Benign Neoplasm, also known as intestinal neoplasms, is related to small intestine cancer and colonic benign neoplasm, and has symptoms including constipation and diarrhea. An important gene associated with Intestinal Benign Neoplasm is CTNNB1 (Catenin Beta 1), and among its related pathways/superpathways are Human cytomegalovirus infection and PI3K-Akt signaling pathway. Affiliated tissues include testes, colon and small intestine, and related phenotypes are homeostasis/metabolism and mortality/aging

Related Diseases for Intestinal Benign Neoplasm

Diseases related to Intestinal Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 169)
# Related Disease Score Top Affiliating Genes
1 small intestine cancer 32.4 CDX2 HRAS KRAS MLH1 MUC2
2 colonic benign neoplasm 31.2 AREG CEACAM5 CTNNB1 HPGD KRAS LGR5
3 gastric cancer 29.9 APC CCND1 CDX2 CEACAM5 CTNNB1 GAST
4 familial adenomatous polyposis 29.2 APC CCND1 CTNNB1 KRAS MLH1 MUTYH
5 adenocarcinoma 29.1 APC CCND1 CTNNB1 HRAS KRAS MLH1
6 colon adenocarcinoma 29.0 APC CEACAM5 CTNNB1 KRAS MLH1 ODC1
7 large intestine adenoma 11.1
8 rectum adenoma 11.1
9 desmoid disease, hereditary 10.3 APC CTNNB1
10 adult hepatocellular carcinoma 10.3 CTNNB1 TP53
11 familial adenomatous polyposis 1 10.3 APC CTNNB1
12 rare adenocarcinoma of the breast 10.3 KRAS TP53
13 periampullary adenoma 10.3 APC HRAS KRAS
14 barrett's adenocarcinoma 10.2 KRAS PTGS2 TP53
15 juvenile polyposis syndrome 10.2 APC MUTYH PTGS2
16 bladder adenocarcinoma 10.2 CDX2 CTNNB1 HRAS
17 liver angiosarcoma 10.2 HRAS KRAS TP53
18 protoplasmic astrocytoma 10.2 PTGS2 TP53
19 colon adenoma 10.2 APC KRAS LGR5
20 paronychia 10.2 HRAS KRAS
21 anal canal adenocarcinoma 10.2 CDX2 HRAS KRAS
22 ureteral obstruction 10.2 CTNNB1 PTGS2 TP53
23 adenosquamous colon carcinoma 10.2 CDX2 MLH1
24 peutz-jeghers syndrome 10.2 APC CTNNB1 TP53
25 lung benign neoplasm 10.2 HRAS KRAS TP53
26 esophagus adenocarcinoma 10.2 CDX2 PTGS2 TP53
27 mucinous intrahepatic cholangiocarcinoma 10.2 CDX2 MUC2
28 anal squamous cell carcinoma 10.2 APC MLH1 TP53
29 schimmelpenning-feuerstein-mims syndrome 10.2 HRAS KRAS
30 mismatch repair cancer syndrome 10.2 APC CTNNB1 MLH1
31 gallbladder adenoma 10.2 CTNNB1 HRAS
32 leukemia, chronic lymphocytic 2 10.2 HRAS KRAS TP53
33 cervical adenocarcinoma 10.2 CDX2 PTGS2 TP53
34 colloid carcinoma of the pancreas 10.2 HRAS KRAS MUC2
35 keratocystic odontogenic tumor 10.2 CCND1 PTGS2 TP53
36 nasopharyngeal disease 10.2 CCND1 CTNNB1 TP53
37 atypical teratoid rhabdoid tumor 10.2 CCND1 CTNNB1 TP53
38 duodenum adenocarcinoma 10.2 CDX2 KRAS MUC2
39 pharynx cancer 10.2 CCND1 CTNNB1 TP53
40 carcinosarcoma 10.2 CTNNB1 HRAS KRAS TP53
41 hyperplastic polyposis syndrome 10.2 APC KRAS MUTYH TP53
42 mutyh-associated polyposis 10.2 APC KRAS MUTYH TP53
43 uterine carcinosarcoma 10.2 CTNNB1 HRAS PTGS2 TP53
44 duodenal disease 10.2 CDX2 KRAS MUC2
45 hepatoblastoma 10.2 APC CTNNB1 TP53
46 ductal carcinoma in situ 10.2 CCND1 PTGS2 TP53
47 cystitis cystica 10.2 CDX2 CTNNB1 MUC2
48 gastric tubular adenocarcinoma 10.2 CDX2 MUC2 PTGS2
49 tongue cancer 10.2 CCND1 CTNNB1 TP53
50 polyposis syndrome, hereditary mixed, 1 10.2 APC MLH1 MUTYH PTGS2

Graphical network of the top 20 diseases related to Intestinal Benign Neoplasm:



Diseases related to Intestinal Benign Neoplasm

Symptoms & Phenotypes for Intestinal Benign Neoplasm

UMLS symptoms related to Intestinal Benign Neoplasm:


constipation, diarrhea

MGI Mouse Phenotypes related to Intestinal Benign Neoplasm:

46 (show all 17)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.4 APC AREG CCND1 CDX2 CTNNB1 GAST
2 mortality/aging MP:0010768 10.39 APC AREG CCND1 CDX2 CTNNB1 GAST
3 cellular MP:0005384 10.37 APC CCND1 CDX2 CTNNB1 HPGD KRAS
4 endocrine/exocrine gland MP:0005379 10.37 APC AREG CCND1 CDX2 CTNNB1 GAST
5 digestive/alimentary MP:0005381 10.35 APC AREG CCND1 CDX2 CTNNB1 GAST
6 growth/size/body region MP:0005378 10.32 APC AREG CCND1 CDX2 CTNNB1 HRAS
7 cardiovascular system MP:0005385 10.31 APC AREG CCND1 CDX2 CTNNB1 HPGD
8 neoplasm MP:0002006 10.25 APC CCND1 CDX2 CTNNB1 GAST HRAS
9 integument MP:0010771 10.22 APC AREG CCND1 CTNNB1 HRAS KRAS
10 craniofacial MP:0005382 10.09 APC CCND1 CTNNB1 HRAS KRAS LGR5
11 normal MP:0002873 10.02 APC CCND1 CDX2 CTNNB1 HRAS KRAS
12 reproductive system MP:0005389 10 APC AREG CCND1 CDX2 CTNNB1 HPGD
13 no phenotypic analysis MP:0003012 9.95 APC CTNNB1 HRAS KRAS MTHFR PTGS2
14 renal/urinary system MP:0005367 9.87 APC CTNNB1 HRAS KRAS LGR5 PTGS2
15 respiratory system MP:0005388 9.76 CCND1 CTNNB1 HRAS KRAS LGR5 MLH1
16 skeleton MP:0005390 9.61 APC CCND1 CDX2 CTNNB1 HRAS KRAS
17 vision/eye MP:0005391 9.28 APC AREG CCND1 CTNNB1 KRAS MLH1

Drugs & Therapeutics for Intestinal Benign Neoplasm

Search Clinical Trials , NIH Clinical Center for Intestinal Benign Neoplasm

Cochrane evidence based reviews: intestinal neoplasms

Genetic Tests for Intestinal Benign Neoplasm

Anatomical Context for Intestinal Benign Neoplasm

MalaCards organs/tissues related to Intestinal Benign Neoplasm:

41
Testes, Colon, Small Intestine, Lung, Liver, Pancreas, Thyroid

The Foundational Model of Anatomy Ontology organs/tissues related to Intestinal Benign Neoplasm:

19
The Intestine

Publications for Intestinal Benign Neoplasm

Articles related to Intestinal Benign Neoplasm:

(show all 25)
# Title Authors Year
1
Transposon mutagenesis identifies candidate genes that cooperate with loss of transforming growth factor-beta signaling in mouse intestinal neoplasms. ( 27790711 )
2017
2
Interplay of host microbiota, genetic perturbations, and inflammation promotes local development of intestinal neoplasms in mice. ( 24590763 )
2014
3
Monoallelic silencing and haploinsufficiency in early murine intestinal neoplasms. ( 22308460 )
2012
4
Alginate-folic acid-modified chitosan nanoparticles for photodynamic detection of intestinal neoplasms. ( 21163518 )
2011
5
C57BL/KsJ-db/db-Apc mice exhibit an increased incidence of intestinal neoplasms. ( 22174655 )
2011
6
TGF-beta receptor inactivation and mutant Kras induce intestinal neoplasms in mice via a beta-catenin-independent pathway. ( 19208363 )
2009
7
Transforming growth factor beta receptor type II inactivation induces the malignant transformation of intestinal neoplasms initiated by Apc mutation. ( 17047044 )
2006
8
Small intestinal neoplasms. ( 11588539 )
2001
9
M30 expression demonstrates apoptotic cells, correlates with in situ end-labeling, and is associated with Ki-67 expression in large intestinal neoplasms. ( 11100055 )
2000
10
Acromegaly and intestinal neoplasms. ( 10479917 )
1999
11
Acromegaly and intestinal neoplasms. ( 10953728 )
1999
12
Enterouterine fistulas: two rare cases of intestinal neoplasms manifested by gynecologic symptoms. ( 2406939 )
1990
13
Cell kinetics analysis of background colonic mucosa of patients with intestinal neoplasms by ex vivo autoradiography. ( 2840368 )
1988
14
Growth factors and intestinal neoplasms. ( 3278641 )
1988
15
Demonstration of vincristine resistance in primary intestinal neoplasms in the rat by the 'post-metaphase index'. ( 4063135 )
1985
16
Natural history of intestinal neoplasms induced in rats by a single injection of methyl(acetoxymethyl)nitrosamine. ( 195717 )
1977
17
Pathology of intestinal neoplasms and other lesions in rats exposed to azoxymethane. ( 4355212 )
1973
18
Environmental temperature and death-rate from intestinal neoplasms. ( 4177953 )
1968
19
Intestinal neoplasms associated with inguinal hernia. ( 4992888 )
1968
20
The induction of intestinal neoplasms in rats with the glycoside cycasin and its aglycone. ( 5296742 )
1965
21
TWO CASES OF MALIGNANT INTESTINAL NEOPLASMS IN DOGS. ( 14105246 )
1964
22
Heterotopic ossification in intestinal neoplasms. ( 13218132 )
1955
23
Two unusual small intestinal neoplasms, both with anaemia. ( 13083805 )
1953
24
Ossification in intestinal neoplasms; a report of three cases. ( 14851176 )
1951
25
Diagnosis of intestinal neoplasms. ( 14874091 )
1951

Variations for Intestinal Benign Neoplasm

Expression for Intestinal Benign Neoplasm

Search GEO for disease gene expression data for Intestinal Benign Neoplasm.

Pathways for Intestinal Benign Neoplasm

Pathways related to Intestinal Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 49)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.04 CCND1 CTNNB1 HRAS KRAS PTGS2 TP53
2
Show member pathways
12.88 APC AREG CCND1 CTNNB1 HRAS KRAS
3
Show member pathways
12.72 APC AREG CCND1 CTNNB1 HRAS KRAS
4
Show member pathways
12.68 APC CTNNB1 HRAS KRAS PTGS2 TP53
5 12.64 APC CCND1 CTNNB1 HRAS KRAS MLH1
6
Show member pathways
12.5 AREG CCND1 CTNNB1 HRAS KRAS TP53
7
Show member pathways
12.48 APC HRAS KRAS LGR5 TP53
8 12.46 APC CCND1 HRAS KRAS PTGS2 TP53
9
Show member pathways
12.45 AREG CCND1 HRAS KRAS TP53
10
Show member pathways
12.42 CTNNB1 HRAS KRAS TP53
11
Show member pathways
12.4 CCND1 CTNNB1 HRAS KRAS
12
Show member pathways
12.4 APC CCND1 CTNNB1 HRAS KRAS
13
Show member pathways
12.38 CTNNB1 HRAS KRAS PTGS2
14
Show member pathways
12.38 APC AREG CTNNB1 HRAS KRAS
15 12.37 APC CCND1 CTNNB1 GAST PTGS2 TP53
16 12.36 APC CCND1 CTNNB1 HRAS KRAS TP53
17 12.27 CCND1 HRAS KRAS TP53
18 12.27 CCND1 CTNNB1 HRAS KRAS TP53
19
Show member pathways
12.18 CCND1 HRAS KRAS TP53
20 12.15 CCND1 HRAS KRAS TP53
21 12.12 CCND1 HRAS KRAS TP53
22 12.12 APC AREG CCND1 CTNNB1
23
Show member pathways
12.11 APC CTNNB1 LGR5 TP53
24 12.11 CCND1 CTNNB1 KRAS ODC1 TP53
25 12.07 APC CTNNB1 HRAS KRAS
26 12 APC CTNNB1 HRAS KRAS
27
Show member pathways
11.95 APC CCND1 CTNNB1 GAST PTGS2 TP53
28
Show member pathways
11.94 APC CCND1 CDX2 CTNNB1 HRAS KRAS
29 11.92 CCND1 CTNNB1 HRAS KRAS TP53
30 11.88 CCND1 HRAS KRAS
31 11.85 CCND1 PTGS2 TP53
32 11.79 APC CCND1 CTNNB1 HRAS KRAS TP53
33 11.76 APC CCND1 CTNNB1
34 11.72 CCND1 HRAS KRAS TP53
35 11.72 APC CCND1 CTNNB1 KRAS MLH1 PTGS2
36 11.68 APC CCND1 CTNNB1 HRAS KRAS TP53
37 11.66 HRAS KRAS TP53
38 11.66 HRAS KRAS TP53
39 11.57 HRAS KRAS MLH1 TP53
40 11.57 APC CCND1 TP53
41 11.56 APC CCND1 CTNNB1
42 11.53 CCND1 PTGS2 TP53
43 11.5 HRAS KRAS PTGS2
44 11.48 APC CCND1 CTNNB1
45 11.29 HRAS KRAS TP53
46 11.18 APC CTNNB1 HRAS KRAS
47 11.15 APC CCND1 CTNNB1
48 11.12 CCND1 HRAS KRAS
49 10.81 HRAS KRAS

GO Terms for Intestinal Benign Neoplasm

Cellular components related to Intestinal Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 beta-catenin destruction complex GO:0030877 8.96 APC CTNNB1
2 Wnt signalosome GO:1990909 8.62 APC CTNNB1

Biological processes related to Intestinal Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 cellular response to DNA damage stimulus GO:0006974 9.88 APC CCND1 MLH1 MUTYH TP53
2 negative regulation of cell proliferation GO:0008285 9.8 APC CTNNB1 HRAS PTGS2 TP53
3 positive regulation of apoptotic process GO:0043065 9.65 APC CTNNB1 HPGD PTGS2 TP53
4 Ras protein signal transduction GO:0007265 9.63 HRAS KRAS TP53
5 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.54 HRAS KRAS MUC2
6 ovulation GO:0030728 9.49 HPGD PTGS2
7 response to glucocorticoid GO:0051384 9.46 AREG CCND1 KRAS PTGS2
8 mitotic G1 DNA damage checkpoint GO:0031571 9.43 CCND1 TP53
9 response to estradiol GO:0032355 9.35 AREG CCND1 CTNNB1 HPGD PTGS2
10 response to isolation stress GO:0035900 9.32 HRAS KRAS
11 positive regulation of cell proliferation GO:0008284 9.23 AREG CCND1 CDX2 CTNNB1 HRAS KRAS

Molecular functions related to Intestinal Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 9.02 CCND1 CTNNB1 MLH1 PTGS2 TP53
2 MutSalpha complex binding GO:0032407 8.96 MLH1 MUTYH

Sources for Intestinal Benign Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....