MCID: INT006
MIFTS: 23

Intestinal Botulism

Categories: Neuronal diseases, Infectious diseases, Rare diseases, Gastrointestinal diseases

Aliases & Classifications for Intestinal Botulism

MalaCards integrated aliases for Intestinal Botulism:

Name: Intestinal Botulism 12 59 15 73
Intestinal Toxin-Mediated Botulism 59
Intestinal Colonization Botulism 59
Intestinal Toxemia Botulism 59

Characteristics:

Orphanet epidemiological data:

59
intestinal botulism
Age of onset: All ages; Age of death: any age;

HPO:

32
intestinal botulism:
Mortality/Aging death in infancy


Classifications:



External Ids:

Disease Ontology 12 DOID:0050141
Orphanet 59 ORPHA178481
UMLS via Orphanet 74 C1443901
ICD10 via Orphanet 34 A05.1
UMLS 73 C1443901

Summaries for Intestinal Botulism

Disease Ontology : 12 A botulism that involves intoxication caused by botulinum neurotoxins (BoNTA, B, E and F) in adults, has material basis in Clostridium botulinum A, has material basis in Clostridium botulinum B, has material basis in Clostridium botulinum E and has material basis in Clostridium botulinum F, which are transmitted by ingestion of bacterial spores, which then grow in the intestine and release toxins.

MalaCards based summary : Intestinal Botulism, also known as intestinal toxin-mediated botulism, is related to infant botulism and adult intestinal botulism. An important gene associated with Intestinal Botulism is LY96 (Lymphocyte Antigen 96), and among its related pathways/superpathways is Class I MHC mediated antigen processing and presentation. Affiliated tissues include colon, and related phenotypes are xerostomia and ptosis

Related Diseases for Intestinal Botulism

Diseases in the Intestinal Botulism family:

Adult Intestinal Botulism

Diseases related to Intestinal Botulism via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 infant botulism 30.5 FBXW2 LY96
2 adult intestinal botulism 12.1
3 wound botulism 9.3 FBXW2 LY96
4 miller-dieker lissencephaly syndrome 9.0 FBXW2 LY96

Symptoms & Phenotypes for Intestinal Botulism

Human phenotypes related to Intestinal Botulism:

59 32 (show all 13)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 xerostomia 59 32 frequent (33%) Frequent (79-30%) HP:0000217
2 ptosis 59 32 hallmark (90%) Very frequent (99-80%) HP:0000508
3 diplopia 59 32 hallmark (90%) Very frequent (99-80%) HP:0000651
4 muscular hypotonia 59 32 hallmark (90%) Very frequent (99-80%) HP:0001252
5 dysarthria 59 32 hallmark (90%) Very frequent (99-80%) HP:0001260
6 diarrhea 59 32 frequent (33%) Frequent (79-30%) HP:0002014
7 dysphagia 59 32 hallmark (90%) Very frequent (99-80%) HP:0002015
8 nausea and vomiting 59 32 frequent (33%) Frequent (79-30%) HP:0002017
9 dyspnea 59 32 occasional (7.5%) Occasional (29-5%) HP:0002094
10 respiratory insufficiency due to muscle weakness 59 32 occasional (7.5%) Occasional (29-5%) HP:0002747
11 cranial nerve paralysis 59 32 hallmark (90%) Very frequent (99-80%) HP:0006824
12 mydriasis 59 32 hallmark (90%) Very frequent (99-80%) HP:0011499
13 death in infancy 59 Occasional (29-5%)

Drugs & Therapeutics for Intestinal Botulism

Search Clinical Trials , NIH Clinical Center for Intestinal Botulism

Genetic Tests for Intestinal Botulism

Anatomical Context for Intestinal Botulism

MalaCards organs/tissues related to Intestinal Botulism:

41
Colon

Publications for Intestinal Botulism

Articles related to Intestinal Botulism:

# Title Authors Year
1
Immunoproteomics Approach for Screening Vaccine Candidates against the Intestinal Botulism. ( 28393685 )
2017
2
Considering the antimicrobial sensitivity of the intestinal botulism agent Clostridium butyricum when treating concomitant infections. ( 14758873 )
2003

Variations for Intestinal Botulism

Expression for Intestinal Botulism

Search GEO for disease gene expression data for Intestinal Botulism.

Pathways for Intestinal Botulism

Pathways related to Intestinal Botulism according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.8 FBXW2 LY96

GO Terms for Intestinal Botulism

Sources for Intestinal Botulism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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