MCID: INT006
MIFTS: 30

Intestinal Botulism

Categories: Eye diseases, Gastrointestinal diseases, Infectious diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Intestinal Botulism

MalaCards integrated aliases for Intestinal Botulism:

Name: Intestinal Botulism 12 58 15 71
Intestinal Toxin-Mediated Botulism 58
Intestinal Colonization Botulism 58
Intestinal Toxemia Botulism 58

Characteristics:

Orphanet epidemiological data:

58
intestinal botulism
Age of onset: All ages; Age of death: any age;

HPO:

31
intestinal botulism:
Clinical modifier death in infancy


Classifications:

Orphanet: 58  
Rare neurological diseases
Rare eye diseases
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:0050141
ICD10 via Orphanet 33 A05.1
UMLS via Orphanet 72 C1443901
Orphanet 58 ORPHA178481
UMLS 71 C1443901

Summaries for Intestinal Botulism

Disease Ontology : 12 A botulism that involves intoxication caused by botulinum neurotoxins (BoNTA, B, E and F) in adults, has material basis in Clostridium botulinum A, has material basis in Clostridium botulinum B, has material basis in Clostridium botulinum E and has material basis in Clostridium botulinum F, which are transmitted by ingestion of bacterial spores, which then grow in the intestine and release toxins.

MalaCards based summary : Intestinal Botulism, also known as intestinal toxin-mediated botulism, is related to infant botulism and wound botulism. An important gene associated with Intestinal Botulism is FBXW2 (F-Box And WD Repeat Domain Containing 2), and among its related pathways/superpathways are Uptake and actions of bacterial toxins and Toxicity of botulinum toxin type F (BoNT/F). Affiliated tissues include colon and eye, and related phenotypes are muscular hypotonia and cranial nerve paralysis

Related Diseases for Intestinal Botulism

Diseases in the Intestinal Botulism family:

Adult Intestinal Botulism

Diseases related to Intestinal Botulism via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 19)
# Related Disease Score Top Affiliating Genes
1 infant botulism 29.2 SYT2 SV2C SV2A NSF GPA33 BRD3
2 wound botulism 27.8 SV2A NSF LY96 GPA33 FBXW2 BRD3
3 foodborne botulism 27.3 SYT2 SV2C SV2A NSF GPA33 BRD3
4 adult intestinal botulism 12.5
5 colorectal cancer 10.2
6 meckel diverticulum 10.2
7 leukemia, acute myeloid 10.2
8 inflammatory bowel disease 10.2
9 crohn's colitis 10.2
10 ptosis 10.2
11 acute leukemia 10.2
12 constipation 10.2
13 appendicitis 10.2
14 guillain-barre syndrome 10.1
15 crohn's disease 10.1
16 enterocolitis 10.0
17 short bowel syndrome 10.0
18 acute laryngopharyngitis 9.8 LY96 FBXW2
19 neurotic disorder 9.6 LY96 FBXW2

Graphical network of the top 20 diseases related to Intestinal Botulism:



Diseases related to Intestinal Botulism

Symptoms & Phenotypes for Intestinal Botulism

Human phenotypes related to Intestinal Botulism:

58 31 (show all 13)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 muscular hypotonia 58 31 hallmark (90%) Very frequent (99-80%) HP:0001252
2 cranial nerve paralysis 58 31 hallmark (90%) Very frequent (99-80%) HP:0006824
3 dysphagia 58 31 hallmark (90%) Very frequent (99-80%) HP:0002015
4 ptosis 58 31 hallmark (90%) Very frequent (99-80%) HP:0000508
5 dysarthria 58 31 hallmark (90%) Very frequent (99-80%) HP:0001260
6 diplopia 58 31 hallmark (90%) Very frequent (99-80%) HP:0000651
7 mydriasis 58 31 hallmark (90%) Very frequent (99-80%) HP:0011499
8 xerostomia 58 31 frequent (33%) Frequent (79-30%) HP:0000217
9 nausea and vomiting 58 31 frequent (33%) Frequent (79-30%) HP:0002017
10 diarrhea 58 31 frequent (33%) Frequent (79-30%) HP:0002014
11 dyspnea 58 31 occasional (7.5%) Occasional (29-5%) HP:0002094
12 respiratory insufficiency due to muscle weakness 58 31 occasional (7.5%) Occasional (29-5%) HP:0002747
13 death in infancy 58 Occasional (29-5%)

Drugs & Therapeutics for Intestinal Botulism

Search Clinical Trials , NIH Clinical Center for Intestinal Botulism

Genetic Tests for Intestinal Botulism

Anatomical Context for Intestinal Botulism

MalaCards organs/tissues related to Intestinal Botulism:

40
Colon, Eye

Publications for Intestinal Botulism

Articles related to Intestinal Botulism:

(show all 14)
# Title Authors PMID Year
1
Adult Intestinal Toxemia Botulism. 61
31991691 2020
2
Medical treatment for botulism. 61
30993666 2019
3
Adult Intestinal Botulism: A Rare Presentation in an Immunocompromised Patient With Short Bowel Syndrome. 61
30225463 2018
4
Identification of Cross Reactive Antigens of C. botulinum Types A, B, E & F by Immunoproteomic Approach. 61
29332140 2018
5
Immunoproteomics Approach for Screening of Vaccine Candidates against Intestinal Botulism. 61
28393685 2017
6
Medical treatment for botulism. 61
24558013 2014
7
Uptake of botulinum neurotoxin in the intestine. 61
23239348 2013
8
[Practice of botulism]. 61
21747147 2011
9
Medical treatment for botulism. 61
21412916 2011
10
Intestinal toxemia botulism in Italy, 1984-2005. 61
17516104 2007
11
Bichat guidelines for the clinical management of botulism and bioterrorism-related botulism. 61
29183487 2004
12
Bichat guidelines for the clinical management of botulism and bioterrorism-related botulism. 61
15677843 2004
13
Considering the antimicrobial sensitivity of the intestinal botulism agent Clostridium butyricum when treating concomitant infections. 61
14758873 2003
14
A case if infant botulism due to neurotoxigenic Clostridium butyricum type E associated with Clostridium difficile colitis. 61
12479171 2002

Variations for Intestinal Botulism

Expression for Intestinal Botulism

Search GEO for disease gene expression data for Intestinal Botulism.

Pathways for Intestinal Botulism

GO Terms for Intestinal Botulism

Cellular components related to Intestinal Botulism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of synaptic vesicle membrane GO:0030285 9.16 SV2C SV2A
2 synaptic vesicle GO:0008021 9.13 SYT2 SV2C SV2A
3 synaptic vesicle membrane GO:0030672 8.8 SYT2 SV2C SV2A

Biological processes related to Intestinal Botulism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neurotransmitter transport GO:0006836 8.62 SV2C SV2A

Molecular functions related to Intestinal Botulism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 SNARE binding GO:0000149 8.96 SYT2 NSF
2 syntaxin binding GO:0019905 8.62 SYT2 NSF

Sources for Intestinal Botulism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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