MCID: INT006
MIFTS: 24

Intestinal Botulism

Categories: Eye diseases, Gastrointestinal diseases, Infectious diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Intestinal Botulism

MalaCards integrated aliases for Intestinal Botulism:

Name: Intestinal Botulism 12 60 15 74
Intestinal Toxin-Mediated Botulism 60
Intestinal Colonization Botulism 60
Intestinal Toxemia Botulism 60

Characteristics:

Orphanet epidemiological data:

60
intestinal botulism
Age of onset: All ages; Age of death: any age;

HPO:

33
intestinal botulism:
Clinical modifier death in infancy


Classifications:



External Ids:

Disease Ontology 12 DOID:0050141
ICD10 via Orphanet 35 A05.1
UMLS via Orphanet 75 C1443901
Orphanet 60 ORPHA178481
UMLS 74 C1443901

Summaries for Intestinal Botulism

Disease Ontology : 12 A botulism that involves intoxication caused by botulinum neurotoxins (BoNTA, B, E and F) in adults, has material basis in Clostridium botulinum A, has material basis in Clostridium botulinum B, has material basis in Clostridium botulinum E and has material basis in Clostridium botulinum F, which are transmitted by ingestion of bacterial spores, which then grow in the intestine and release toxins.

MalaCards based summary : Intestinal Botulism, also known as intestinal toxin-mediated botulism, is related to infant botulism and adult intestinal botulism. An important gene associated with Intestinal Botulism is LY96 (Lymphocyte Antigen 96), and among its related pathways/superpathways is Class I MHC mediated antigen processing and presentation. Affiliated tissues include colon and eye, and related phenotypes are ptosis and diplopia

Related Diseases for Intestinal Botulism

Diseases in the Intestinal Botulism family:

Adult Intestinal Botulism

Diseases related to Intestinal Botulism via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 infant botulism 31.3 FBXW2 LY96
2 adult intestinal botulism 12.4
3 acute leukemia 10.2
4 leukemia 10.2
5 foodborne botulism 10.2
6 crohn's disease 10.0
7 short bowel syndrome 9.9
8 wound botulism 9.7 FBXW2 LY96
9 miller-dieker lissencephaly syndrome 9.5 FBXW2 LY96

Graphical network of the top 20 diseases related to Intestinal Botulism:



Diseases related to Intestinal Botulism

Symptoms & Phenotypes for Intestinal Botulism

Human phenotypes related to Intestinal Botulism:

60 33 (show all 13)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 ptosis 60 33 hallmark (90%) Very frequent (99-80%) HP:0000508
2 diplopia 60 33 hallmark (90%) Very frequent (99-80%) HP:0000651
3 muscular hypotonia 60 33 hallmark (90%) Very frequent (99-80%) HP:0001252
4 dysarthria 60 33 hallmark (90%) Very frequent (99-80%) HP:0001260
5 dysphagia 60 33 hallmark (90%) Very frequent (99-80%) HP:0002015
6 cranial nerve paralysis 60 33 hallmark (90%) Very frequent (99-80%) HP:0006824
7 mydriasis 60 33 hallmark (90%) Very frequent (99-80%) HP:0011499
8 nausea and vomiting 60 33 frequent (33%) Frequent (79-30%) HP:0002017
9 xerostomia 60 33 frequent (33%) Frequent (79-30%) HP:0000217
10 diarrhea 60 33 frequent (33%) Frequent (79-30%) HP:0002014
11 dyspnea 60 33 occasional (7.5%) Occasional (29-5%) HP:0002094
12 respiratory insufficiency due to muscle weakness 60 33 occasional (7.5%) Occasional (29-5%) HP:0002747
13 death in infancy 60 Occasional (29-5%)

Drugs & Therapeutics for Intestinal Botulism

Search Clinical Trials , NIH Clinical Center for Intestinal Botulism

Genetic Tests for Intestinal Botulism

Anatomical Context for Intestinal Botulism

MalaCards organs/tissues related to Intestinal Botulism:

42
Colon, Eye

Publications for Intestinal Botulism

Articles related to Intestinal Botulism:

# Title Authors Year
1
Adult Intestinal Botulism: A Rare Presentation in an Immunocompromised Patient With Short Bowel Syndrome. ( 30225463 )
2018
2
Immunoproteomics Approach for Screening of Vaccine Candidates against Intestinal Botulism. ( 28393685 )
2017
3
Considering the antimicrobial sensitivity of the intestinal botulism agent Clostridium butyricum when treating concomitant infections. ( 14758873 )
2003

Variations for Intestinal Botulism

Expression for Intestinal Botulism

Search GEO for disease gene expression data for Intestinal Botulism.

Pathways for Intestinal Botulism

Pathways related to Intestinal Botulism according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.8 FBXW2 LY96

GO Terms for Intestinal Botulism

Sources for Intestinal Botulism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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