Intestinal Botulism disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Intestinal Botulism

MalaCards integrated aliases for Intestinal Botulism:

Name: Intestinal Botulism ¹² ⁵⁸ ¹⁵ ⁷¹

Intestinal Toxin-Mediated Botulism ⁵⁸

Intestinal Colonization Botulism ⁵⁸

Intestinal Toxemia Botulism ⁵⁸

Characteristics:

Orphanet epidemiological data:

⁵⁸

intestinal botulism
Age of onset: All ages; Age of death: any age;

HPO:

³¹

intestinal botulism:
Onset and clinical course death in infancy

Classifications:

MalaCards categories:
Global: Infectious diseases Rare diseases
Anatomical: Neuronal diseases Eye diseases Gastrointestinal diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Certain infectious and parasitic diseases

Intestinal infectious diseases

Other bacterial foodborne intoxications, not elsewhere classified

Botulism

Orphanet: ⁵⁸

Rare neurological diseases

Rare eye diseases

Rare infectious diseases

External Ids:

Disease Ontology ¹² DOID:0050141

ICD10 via Orphanet ³³ A05.1

UMLS via Orphanet ⁷² C1443901

Orphanet ⁵⁸ ORPHA178481

SNOMED-CT via HPO ⁶⁸ 11934000 16932000 230145002 more

UMLS ⁷¹ C1443901

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Summaries for Intestinal Botulism

Disease Ontology : ¹² A botulism that involves intoxication caused by botulinum neurotoxins (BoNTA, B, E and F) in adults, has material basis in Clostridium botulinum A, has material basis in Clostridium botulinum B, has material basis in Clostridium botulinum E and has material basis in Clostridium botulinum F, which are transmitted by ingestion of bacterial spores, which then grow in the intestine and release toxins.

MalaCards based summary : Intestinal Botulism, also known as intestinal toxin-mediated botulism, is related to infant botulism and wound botulism. An important gene associated with Intestinal Botulism is GPA33 (Glycoprotein A33), and among its related pathways/superpathways are ECM-receptor interaction and Uptake and actions of bacterial toxins. Affiliated tissues include eye, and related phenotypes are ptosis and diplopia

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Related Diseases for Intestinal Botulism

Diseases in the Intestinal Botulism family:

Adult Intestinal Botulism

Diseases related to Intestinal Botulism via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 19)

#	Related Disease	Score	Top Affiliating Genes
1	infant botulism	30.1	SYT2 SV2C SV2A GPA33 BRD3
2	wound botulism	29.3	SV2A GPA33 CNTD1 BRD3
3	foodborne botulism	28.5	SYT2 SV2C SV2A GPA33 BRD3
4	adult intestinal botulism	11.2
5	meckel diverticulum	10.1
6	leukemia, acute myeloid	10.1
7	disease by infectious agent	10.1
8	inflammatory bowel disease	10.1
9	crohn's colitis	10.1
10	ptosis	10.1
11	leukemia	10.1
12	acute leukemia	10.1
13	constipation	10.1
14	appendicitis	10.1
15	guillain-barre syndrome	10.1
16	crohn's disease	10.1
17	enterocolitis	9.9
18	short bowel syndrome	9.9
19	alcohol-related birth defect	9.7	SV2C SV2A

Graphical network of the top 20 diseases related to Intestinal Botulism:

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Symptoms & Phenotypes for Intestinal Botulism

Human phenotypes related to Intestinal Botulism:

⁵⁸ ³¹ (show all 14)

#	Description	HPO Frequency	Orphanet Frequency	HPO Source Accession
1	ptosis ⁵⁸ ³¹	hallmark (90%)	Very frequent (99-80%)	HP:0000508
2	diplopia ⁵⁸ ³¹	hallmark (90%)	Very frequent (99-80%)	HP:0000651
3	dysarthria ⁵⁸ ³¹	hallmark (90%)	Very frequent (99-80%)	HP:0001260
4	dysphagia ⁵⁸ ³¹	hallmark (90%)	Very frequent (99-80%)	HP:0002015
5	cranial nerve paralysis ⁵⁸ ³¹	hallmark (90%)	Very frequent (99-80%)	HP:0006824
6	mydriasis ⁵⁸ ³¹	hallmark (90%)	Very frequent (99-80%)	HP:0011499
7	hypotonia ³¹	hallmark (90%)		HP:0001252
8	nausea and vomiting ⁵⁸ ³¹	frequent (33%)	Frequent (79-30%)	HP:0002017
9	diarrhea ⁵⁸ ³¹	frequent (33%)	Frequent (79-30%)	HP:0002014
10	xerostomia ⁵⁸ ³¹	frequent (33%)	Frequent (79-30%)	HP:0000217
11	respiratory insufficiency due to muscle weakness ⁵⁸ ³¹	occasional (7.5%)	Occasional (29-5%)	HP:0002747
12	dyspnea ⁵⁸ ³¹	occasional (7.5%)	Occasional (29-5%)	HP:0002094
13	muscular hypotonia ⁵⁸		Very frequent (99-80%)
14	death in infancy ⁵⁸		Occasional (29-5%)

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Drugs & Therapeutics for Intestinal Botulism

Search Clinical Trials , NIH Clinical Center for Intestinal Botulism

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Genetic Tests for Intestinal Botulism

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Anatomical Context for Intestinal Botulism

MalaCards organs/tissues related to Intestinal Botulism:

⁴⁰

Eye

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Publications for Intestinal Botulism

Articles related to Intestinal Botulism:

(show all 14)

#	Title	Authors	PMID	Year
1	Adult Intestinal Toxemia Botulism. ⁶¹	Harris RA...Austin JW	31991691	2020
2	Medical treatment for botulism. ⁶¹	Chalk CH...Keezer MR	30993666	2019
3	Adult Intestinal Botulism: A Rare Presentation in an Immunocompromised Patient With Short Bowel Syndrome. ⁶¹	Guru PK...Brumble L	30225463	2018
4	Identification of Cross Reactive Antigens of C. botulinum Types A, B, E & F by Immunoproteomic Approach. ⁶¹	Sharma A...Shukla S	29332140	2018
5	Immunoproteomics Approach for Screening of Vaccine Candidates against Intestinal Botulism. ⁶¹	Sharma A...Ponmariappan S	28393685	2017
6	Medical treatment for botulism. ⁶¹	Chalk CH...Keezer M	24558013	2014
7	Uptake of botulinum neurotoxin in the intestine. ⁶¹	Fujinaga Y...Matsumura T	23239348	2013
8	[Practice of botulism]. ⁶¹	Ikeguchi K	21747147	2011
9	Medical treatment for botulism. ⁶¹	Chalk C...Keezer M	21412916	2011
10	Intestinal toxemia botulism in Italy, 1984-2005. ⁶¹	Fenicia L...Aureli P	17516104	2007
11	Bichat guidelines for the clinical management of botulism and bioterrorism-related botulism. ⁶¹	Bossi P...Task Force on Biological and Chemical Agent Threats, Public Health Directorate, European Commission, Luxembourg	15677843	2004
12	Bichat guidelines for the clinical management of botulism and bioterrorism-related botulism. ⁶¹	Bossi P...Gouvras G	29183487	2004
13	Considering the antimicrobial sensitivity of the intestinal botulism agent Clostridium butyricum when treating concomitant infections. ⁶¹	Fenicia L...Aureli P	14758873	2003
14	A case if infant botulism due to neurotoxigenic Clostridium butyricum type E associated with Clostridium difficile colitis. ⁶¹	Fenicia L...Aureli P	12479171	2002

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Genes for Intestinal Botulism

Genes related to Intestinal Botulism (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	GPA33	Glycoprotein A33	Protein Coding	6.64	DISEASES inferred ¹⁵
2	SV2C	Synaptic Vesicle Glycoprotein 2C	Protein Coding	6.49	DISEASES inferred ¹⁵
3	CNTD1	Cyclin N-Terminal Domain Containing 1	Protein Coding	6.24	DISEASES inferred ¹⁵
4	SV2A	Synaptic Vesicle Glycoprotein 2A	Protein Coding	6	DISEASES inferred ¹⁵
5	BRD3	Bromodomain Containing 3	Protein Coding	6	DISEASES inferred ¹⁵
6	SYT2	Synaptotagmin 2	Protein Coding	5.92	DISEASES inferred ¹⁵
7	SVOP	SV2 Related Protein	Protein Coding	5.82	DISEASES inferred ¹⁵

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Variations for Intestinal Botulism

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Expression for Intestinal Botulism

Search GEO for disease gene expression data for Intestinal Botulism.

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Pathways for Intestinal Botulism

Pathways related to Intestinal Botulism according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	ECM-receptor interaction ³⁶ Show member pathways Integrin cell surface interactions ⁶⁵	11.35	SV2C SV2A
2	Uptake and actions of bacterial toxins ⁶⁵ Show member pathways Intestinal infectious diseases ⁶⁵ Neurotoxicity of clostridium toxins ⁶⁵ Toxicity of botulinum toxin type A (BoNT/A) ⁶⁵ Toxicity of botulinum toxin type B (BoNT/B) ⁶⁵ Toxicity of botulinum toxin type C (BoNT/C) ⁶⁵ Toxicity of botulinum toxin type E (BoNT/E) ⁶⁵ Toxicity of botulinum toxin type G (BoNT/G) ⁶⁵ Toxicity of tetanus toxin (TeNT) ⁶⁵ Uptake and function of anthrax toxins ⁶⁵ Uptake and function of diphtheria toxin ⁶⁵	10.7	SYT2 SV2C SV2A
3	Toxicity of botulinum toxin type D (BoNT/D) ⁶⁵ Show member pathways Toxicity of botulinum toxin type F (BoNT/F) ⁶⁵	9.96	SV2C SV2A

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GO Terms for Intestinal Botulism

Cellular components related to Intestinal Botulism according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cell junction	GO:0030054	9.67	SYT2 SVOP SV2C SV2A
2	synapse	GO:0045202	9.56	SYT2 SVOP SV2C SV2A
3	cytoplasmic vesicle	GO:0031410	9.46	SYT2 SVOP SV2C SV2A
4	integral component of synaptic vesicle membrane	GO:0030285	9.32	SV2C SV2A
5	synaptic vesicle	GO:0008021	9.26	SYT2 SVOP SV2C SV2A
6	synaptic vesicle membrane	GO:0030672	8.92	SYT2 SVOP SV2C SV2A

Biological processes related to Intestinal Botulism according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	transmembrane transport	GO:0055085	9.13	SVOP SV2C SV2A
2	neurotransmitter transport	GO:0006836	8.62	SV2C SV2A

Molecular functions related to Intestinal Botulism according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	transmembrane transporter activity	GO:0022857	8.8	SVOP SV2C SV2A

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Sources for Intestinal Botulism

¹ BioSystems

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²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

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²⁷ GEO DataSets

²⁸ GO

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⁴⁰ MalaCards

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⁴⁸ NCBI Bookshelf

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⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 05-Mar-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

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⁶⁹ TGDB

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⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia