MCID: INT050
MIFTS: 27

Intestinal Impaction

Categories: Gastrointestinal diseases

Aliases & Classifications for Intestinal Impaction

MalaCards integrated aliases for Intestinal Impaction:

Name: Intestinal Impaction 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:8448
ICD10 33 K56.4 K56.49
ICD9CM 35 560.39
SNOMED-CT 68 197540000
UMLS 73 C0029640

Summaries for Intestinal Impaction

MalaCards based summary : Intestinal Impaction is related to platelet aggregation, spontaneous and cold urticaria. An important gene associated with Intestinal Impaction is SERPINF2 (Serpin Family F Member 2), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. Related phenotypes are cardiovascular system and hematopoietic system

Related Diseases for Intestinal Impaction

Diseases related to Intestinal Impaction via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 131)
# Related Disease Score Top Affiliating Genes
1 platelet aggregation, spontaneous 10.5 SERPINC1 SERPINF2
2 cold urticaria 10.5 SERPINC1 SERPINF2
3 renal artery obstruction 10.4 REN SERPINC1
4 heparin-induced thrombocytopenia 10.4 F3 SERPINC1
5 factor xiii deficiency 10.4 F3 SERPINF2
6 intracranial thrombosis 10.3 F3 SERPINC1
7 coronary thrombosis 10.3 F3 SERPINC1
8 factor xii deficiency 10.3 F3 SERPINC1
9 acute poststreptococcal glomerulonephritis 10.3 PLG SERPINF2
10 pulmonary immaturity 10.2 F3 SERPINC1
11 acute cor pulmonale 10.2 PLG SERPINF2
12 acute pulmonary heart disease 10.2 PLG SERPINF2
13 conjugate gaze palsy 10.2 F3 PLG
14 rubeosis iridis 10.2 PLG SERPINF2
15 dysbaric osteonecrosis 10.1 F3 PLG
16 placenta disease 10.1 F3 SERPINC1
17 vertebral artery occlusion 10.1 F3 PLG
18 lemierre's syndrome 10.1 F3 PLG
19 spinal cord infarction 10.0 F2 SERPINC1
20 sudden sensorineural hearing loss 10.0 F2 SERPINC1
21 blood protein disease 10.0 F2 SERPINC1
22 prothrombin deficiency, congenital 10.0 F2 SERPINC1
23 ischemic colitis 10.0 F2 SERPINC1
24 subendocardial myocardial infarction 10.0 F2 SERPINC1
25 sneddon syndrome 10.0 F2 SERPINC1
26 retinal artery occlusion 10.0 F2 SERPINC1
27 esophageal varix 10.0 F2 SERPINC1
28 antithrombin iii deficiency 9.9 F2 SERPINC1
29 post-thrombotic syndrome 9.9 F2 SERPINC1
30 hypersplenism 9.9 F2 SERPINC1
31 central retinal vein occlusion 9.9 F2 SERPINC1
32 cerebral sinovenous thrombosis 9.9 F2 F3
33 angina pectoris 9.9 F3 SERPINC1 SERPINF2
34 qualitative platelet defect 9.9 F2 F3
35 von willebrand disease, type 1 9.9 F2 F3
36 portal vein thrombosis 9.9 F2 SERPINC1
37 alcohol-related birth defect 9.9 F2 F3
38 hantavirus pulmonary syndrome 9.9 F2 F3
39 patent foramen ovale 9.9 F2 SERPINC1
40 splenic disease 9.9 F2 F3
41 cardiac tamponade 9.9 F2 REN
42 dysfibrinogenemia 9.9 F2 SERPINC1
43 placental abruption 9.9 F2 SERPINC1
44 hemophilia 9.8 F2 F3
45 protein c deficiency 9.8 F2 SERPINC1
46 endocardium disease 9.8 F2 F3
47 hepatorenal syndrome 9.8 F2 REN
48 ischemic optic neuropathy 9.8 F2 SERPINC1
49 analbuminemia 9.8 F2 F3
50 intermittent claudication 9.8 F2 SERPINC1

Graphical network of the top 20 diseases related to Intestinal Impaction:



Diseases related to Intestinal Impaction

Symptoms & Phenotypes for Intestinal Impaction

MGI Mouse Phenotypes related to Intestinal Impaction:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.55 F2 F3 PLG REN SERPINC1
2 hematopoietic system MP:0005397 9.35 F2 F3 PLG REN SERPINC1
3 homeostasis/metabolism MP:0005376 9.1 F3 PLG REN SERPINC1 SERPINF2 F2

Drugs & Therapeutics for Intestinal Impaction

Search Clinical Trials , NIH Clinical Center for Intestinal Impaction

Genetic Tests for Intestinal Impaction

Anatomical Context for Intestinal Impaction

Publications for Intestinal Impaction

Articles related to Intestinal Impaction:

# Title Authors Year
1
Physiological and pathophysiological factors affecting the expression and activity of the drug transporter MRP2 in intestine. Impact on its function as membrane barrier. ( 27109321 )
2016
2
An adenovirus associated with intestinal impaction and mortality of male common eiders (Somateria mollissima) in the Baltic Sea. ( 12685074 )
2003
3
A method of electro-acupuncture treatment for equine intestinal impaction. ( 7345923 )
1981
4
Amitraz induced large intestinal impaction in the horse. ( 543829 )
1979
5
The use of cholinergic drugs in treating intestinal impaction in the horse. ( 4483119 )
1972

Variations for Intestinal Impaction

Expression for Intestinal Impaction

Search GEO for disease gene expression data for Intestinal Impaction.

Pathways for Intestinal Impaction

GO Terms for Intestinal Impaction

Cellular components related to Intestinal Impaction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.65 F2 F3 PLG SERPINC1 SERPINF2
2 extracellular region GO:0005576 9.63 F2 F3 PLG REN SERPINC1 SERPINF2
3 extracellular space GO:0005615 9.43 F2 F3 PLG REN SERPINC1 SERPINF2
4 platelet alpha granule lumen GO:0031093 9.32 PLG SERPINF2
5 blood microparticle GO:0072562 8.92 F2 PLG SERPINC1 SERPINF2

Biological processes related to Intestinal Impaction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 blood coagulation GO:0007596 9.56 F2 F3 PLG SERPINC1
2 cellular protein metabolic process GO:0044267 9.54 F2 PLG SERPINC1
3 acute-phase response GO:0006953 9.43 F2 SERPINF2
4 positive regulation of collagen biosynthetic process GO:0032967 9.4 F2 SERPINF2
5 fibrinolysis GO:0042730 9.33 F2 PLG SERPINF2
6 regulation of blood coagulation GO:0030193 9.32 F2 SERPINC1
7 negative regulation of fibrinolysis GO:0051918 9.13 F2 PLG SERPINF2
8 hemostasis GO:0007599 8.92 F2 F3 PLG SERPINC1

Molecular functions related to Intestinal Impaction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidase activity GO:0008233 9.5 F2 PLG REN
2 serine-type endopeptidase inhibitor activity GO:0004867 9.37 SERPINC1 SERPINF2
3 signaling receptor binding GO:0005102 9.33 F2 PLG REN
4 endopeptidase activity GO:0004175 9.26 PLG REN
5 serine-type endopeptidase activity GO:0004252 9.13 F2 F3 PLG
6 protease binding GO:0002020 8.8 F3 SERPINC1 SERPINF2

Sources for Intestinal Impaction

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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