MCID: INT050
MIFTS: 30

Intestinal Impaction

Categories: Gastrointestinal diseases

Aliases & Classifications for Intestinal Impaction

MalaCards integrated aliases for Intestinal Impaction:

Name: Intestinal Impaction 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:8448
ICD10 33 K56.4 K56.49
ICD9CM 35 560.39
UMLS 73 C0029640

Summaries for Intestinal Impaction

MalaCards based summary : Intestinal Impaction is related to platelet aggregation, spontaneous and cold urticaria. An important gene associated with Intestinal Impaction is SERPINF2 (Serpin Family F Member 2), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. Affiliated tissues include liver, heart and spinal cord, and related phenotypes are cardiovascular system and hematopoietic system

Related Diseases for Intestinal Impaction

Diseases related to Intestinal Impaction via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 126)
# Related Disease Score Top Affiliating Genes
1 platelet aggregation, spontaneous 10.1 SERPINC1 SERPINF2
2 cold urticaria 10.1 SERPINC1 SERPINF2
3 renal artery obstruction 10.1 REN SERPINC1
4 heparin-induced thrombocytopenia 10.1 F3 SERPINC1
5 factor xiii deficiency 10.1 F3 SERPINF2
6 factor xii deficiency 10.1 F3 SERPINC1
7 acute poststreptococcal glomerulonephritis 10.1 PLG SERPINF2
8 coronary thrombosis 10.1 F3 SERPINC1
9 acute cor pulmonale 10.1 PLG SERPINF2
10 pulmonary immaturity 10.1 F3 SERPINC1
11 acute pulmonary heart disease 10.1 PLG SERPINF2
12 conjugate gaze palsy 10.0 F3 PLG
13 dysbaric osteonecrosis 10.0 F3 PLG
14 vertebral artery occlusion 10.0 F3 PLG
15 lemierre's syndrome 10.0 F3 PLG
16 endocarditis 10.0 F2 SERPINC1
17 retinal artery occlusion 10.0 F2 SERPINC1
18 placenta disease 10.0 F3 SERPINC1
19 spinal cord infarction 10.0 F2 SERPINC1
20 prothrombin deficiency, congenital 10.0 F2 SERPINC1
21 afibrinogenemia 10.0 F2 F3
22 ischemic colitis 10.0 F2 SERPINC1
23 subendocardial myocardial infarction 10.0 F2 SERPINC1
24 sneddon syndrome 10.0 F2 SERPINC1
25 osteonecrosis 10.0 F2 SERPINC1
26 hemophilia 10.0 F2 F3
27 esophageal varix 10.0 F2 SERPINC1
28 antithrombin iii deficiency 10.0 F2 SERPINC1
29 post-thrombotic syndrome 10.0 F2 SERPINC1
30 prothrombin deficiency 10.0 F2 F3
31 hypersplenism 10.0 F2 SERPINC1
32 cerebral sinovenous thrombosis 10.0 F2 F3
33 qualitative platelet defect 10.0 F2 F3
34 central retinal vein occlusion 10.0 F2 SERPINC1
35 retinal vein occlusion 10.0 F2 SERPINC1
36 alcohol-related birth defect 10.0 F2 F3
37 hantavirus pulmonary syndrome 10.0 F2 F3
38 von willebrand disease, type 1 10.0 F2 F3
39 portal vein thrombosis 10.0 F2 SERPINC1
40 cardiac tamponade 10.0 F2 REN
41 vascular hemostatic disease 10.0 F2 F3
42 splenic disease 10.0 F2 F3
43 dysfibrinogenemia 9.9 F2 SERPINC1
44 placental abruption 9.9 F2 SERPINC1
45 protein c deficiency 9.9 F2 SERPINC1
46 hepatorenal syndrome 9.9 F2 REN
47 ischemic optic neuropathy 9.9 F2 SERPINC1
48 carotid artery disease 9.9 PLG REN
49 intermittent claudication 9.9 F2 SERPINC1
50 analbuminemia 9.9 F2 F3

Graphical network of the top 20 diseases related to Intestinal Impaction:



Diseases related to Intestinal Impaction

Symptoms & Phenotypes for Intestinal Impaction

MGI Mouse Phenotypes related to Intestinal Impaction:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.65 F2 F3 PLG REN SERPINC1
2 hematopoietic system MP:0005397 9.55 F2 F3 PLG REN SERPINC1
3 homeostasis/metabolism MP:0005376 9.43 F2 F3 PLG REN SERPINC1 SERPINF2
4 immune system MP:0005387 9.02 F2 F3 PLG REN SERPINC1

Drugs & Therapeutics for Intestinal Impaction

Search Clinical Trials , NIH Clinical Center for Intestinal Impaction

Genetic Tests for Intestinal Impaction

Anatomical Context for Intestinal Impaction

MalaCards organs/tissues related to Intestinal Impaction:

41
Liver, Heart, Spinal Cord, Placenta

Publications for Intestinal Impaction

Articles related to Intestinal Impaction:

# Title Authors Year
1
An adenovirus associated with intestinal impaction and mortality of male common eiders (Somateria mollissima) in the Baltic Sea. ( 12685074 )
2003
2
A method of electro-acupuncture treatment for equine intestinal impaction. ( 7345923 )
1981
3
Amitraz induced large intestinal impaction in the horse. ( 543829 )
1979
4
The use of cholinergic drugs in treating intestinal impaction in the horse. ( 4483119 )
1972

Variations for Intestinal Impaction

Expression for Intestinal Impaction

Search GEO for disease gene expression data for Intestinal Impaction.

Pathways for Intestinal Impaction

GO Terms for Intestinal Impaction

Cellular components related to Intestinal Impaction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.73 F2 F3 PLG REN SERPINC1 SERPINF2
2 collagen-containing extracellular matrix GO:0062023 9.46 F3 PLG SERPINC1 SERPINF2
3 extracellular space GO:0005615 9.43 F2 F3 PLG REN SERPINC1 SERPINF2
4 platelet alpha granule lumen GO:0031093 9.32 PLG SERPINF2
5 blood microparticle GO:0072562 8.92 F2 PLG SERPINC1 SERPINF2

Biological processes related to Intestinal Impaction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 blood coagulation GO:0007596 9.56 F2 F3 PLG SERPINC1
2 cellular protein metabolic process GO:0044267 9.54 F2 PLG SERPINC1
3 response to organic substance GO:0010033 9.46 REN SERPINF2
4 acute-phase response GO:0006953 9.43 F2 SERPINF2
5 positive regulation of collagen biosynthetic process GO:0032967 9.4 F2 SERPINF2
6 fibrinolysis GO:0042730 9.33 F2 PLG SERPINF2
7 regulation of blood coagulation GO:0030193 9.32 F2 SERPINC1
8 negative regulation of fibrinolysis GO:0051918 9.13 F2 PLG SERPINF2
9 hemostasis GO:0007599 8.92 F2 F3 PLG SERPINC1

Molecular functions related to Intestinal Impaction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidase activity GO:0008233 9.5 F2 PLG REN
2 serine-type endopeptidase inhibitor activity GO:0004867 9.37 SERPINC1 SERPINF2
3 signaling receptor binding GO:0005102 9.33 F2 PLG REN
4 endopeptidase activity GO:0004175 9.26 PLG REN
5 serine-type endopeptidase activity GO:0004252 9.13 F2 F3 PLG
6 protease binding GO:0002020 8.8 F3 SERPINC1 SERPINF2

Sources for Intestinal Impaction

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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