MCID: INT070
MIFTS: 56

Intestinal Obstruction

Categories: Fetal diseases, Gastrointestinal diseases, Rare diseases, Neuronal diseases, Genetic diseases

Aliases & Classifications for Intestinal Obstruction

Summaries for Intestinal Obstruction

MedlinePlus : 43 An intestinal obstruction occurs when food or stool cannot move through the intestines. The obstruction can be complete or partial. There are many causes. The most common are adhesions, hernias, cancers, and certain medicines. Symptoms include Severe abdominal pain or cramping Vomiting Bloating Loud bowel sounds Swelling of the abdomen Inability to pass gas Constipation A complete intestinal obstruction is a medical emergency. It often requires surgery. NIH: National Institute of Diabetes and Digestive and Kidney Diseases

MalaCards based summary : Intestinal Obstruction is related to intestinal pseudo-obstruction and hypoganglionosis, and has symptoms including abdominal pain, constipation and diarrhea. An important gene associated with Intestinal Obstruction is GDNF (Glial Cell Derived Neurotrophic Factor), and among its related pathways/superpathways is GDNF-Family Ligands and Receptor Interactions. The drugs Alvimopan and Metronidazole have been mentioned in the context of this disorder. Affiliated tissues include colon, small intestine and kidney, and related phenotypes are behavior/neurological and digestive/alimentary

Related Diseases for Intestinal Obstruction

Diseases in the Intestinal Obstruction family:

Intestinal Pseudo-Obstruction

Diseases related to Intestinal Obstruction via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 270)
# Related Disease Score Top Affiliating Genes
1 intestinal pseudo-obstruction 32.3 EDNRB FLNA RET SGO1
2 hypoganglionosis 32.2 ACHE GDNF RET
3 duodenal atresia 32.0 CFTR GUCY2C
4 intestinal disease 31.1 EDNRB NOD2 RET
5 hirschsprung disease 1 31.0 ACHE EDN3 EDNRB GDNF NRTN RET
6 jejunal adenocarcinoma 29.9 CDX2 KRT7
7 intestinal perforation 29.7 KRT7 NOD2
8 constipation 29.1 EDN3 EDNRB FLNA GDNF MLN RET
9 meconium ileus 12.0
10 intestinal pseudoobstruction, neuronal, chronic idiopathic, x-linked 11.3
11 peritonitis 11.2
12 wandering spleen 11.2
13 visceral myopathy 11.1
14 congenital chloride diarrhea 11.1
15 medullary sponge kidney 10.9 GDNF RET
16 waardenburg syndrome type 4 10.9 EDN3 EDNRB
17 juvenile polyposis syndrome 10.8
18 gastrointestinal defects and immunodeficiency syndrome 10.8
19 hirschsprung disease 2 10.8
20 ascaris lumbricoides infection 10.8
21 hirschsprung disease 3 10.8
22 hirschsprung disease 4 10.8
23 chronic atrial and intestinal dysrhythmia 10.8
24 diphyllobothriasis 10.8
25 pica disease 10.8
26 fasciolopsiasis 10.8
27 actg2-related disorders 10.8
28 abdominal cystic lymphangioma 10.8
29 desmoid tumor 10.8
30 ovarian germ cell teratoma 10.8 KRT7 RET
31 ovarian germ cell cancer 10.8 KRT7 RET
32 multiple endocrine neoplasia, type iib 10.7 EDNRB GDNF RET
33 ovary neuroendocrine neoplasm 10.7 CDX2 KRT7
34 waardenburg syndrome, type 4a 10.7 EDN3 EDNRB RET
35 vaginal benign neoplasm 10.7 CDX2 KRT7
36 appendix adenocarcinoma 10.7 CDX2 KRT7
37 vaginal adenoma 10.7 CDX2 KRT7
38 vaginal tubulovillous adenoma 10.7 CDX2 KRT7
39 mucinous adenofibroma 10.7 CDX2 KRT7
40 anus adenocarcinoma 10.7 CDX2 KRT7
41 glandular cystitis 10.7 CDX2 KRT7
42 thyroid carcinoma, familial medullary 10.7 EDNRB GDNF RET
43 intussusception 10.7
44 lichen nitidus 10.6 FLNA RET
45 waardenburg's syndrome 10.6 EDN3 EDNRB RET
46 mucinous bronchioloalveolar adenocarcinoma 10.6 CDX2 KRT7
47 epithelial predominant wilms' tumor 10.6 CDX2 KRT7
48 thyroid cancer, nonmedullary, 2 10.6 EDNRB GDNF RET
49 large intestine adenocarcinoma 10.6 KRT7 MTOR
50 ovarian mucinous adenocarcinoma 10.6 CDX2 KRT7

Comorbidity relations with Intestinal Obstruction via Phenotypic Disease Network (PDN): (show top 50) (show all 59)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Acute Pancreatitis
Acute Vascular Insufficiency of Intestine Anxiety
Ascending Colon Cancer Bronchitis
Candidiasis Cecal Benign Neoplasm
Cervical Cancer Chronic Intestinal Vascular Insufficiency
Chronic Kidney Failure Chronic Myocardial Ischemia
Chylomicron Retention Disease Colorectal Cancer
Crohn's Disease Decubitus Ulcer
Deficiency Anemia Descending Colon Cancer
Enterovesical Fistula Esophageal Disease
Esophagitis Familial Atrial Fibrillation
Gastric Cancer Gastrointestinal System Cancer
Generalized Atherosclerosis Heart Disease
Hepatic Flexure Cancer Hydronephrosis
Hypertension, Essential Hypothyroidism
Inflammatory Bowel Disease 1 Intestinal Disease
Intestinal Perforation Intestinal Volvulus
Iron Deficiency Anemia Irritable Bowel Syndrome
Jejunal Cancer Kidney Disease
Marasmus Neutropenia
Osteoporosis Ovarian Cancer
Pancreatic Cancer Pancreatitis, Hereditary
Paralytic Ileus Peritonitis
Postgastrectomy Syndrome Protein-Energy Malnutrition

Graphical network of the top 20 diseases related to Intestinal Obstruction:



Diseases related to Intestinal Obstruction

Symptoms & Phenotypes for Intestinal Obstruction

UMLS symptoms related to Intestinal Obstruction:


abdominal pain, constipation, diarrhea, dyspepsia, heartburn, icterus, nausea and vomiting, gastrointestinal gas

MGI Mouse Phenotypes related to Intestinal Obstruction:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.23 ACHE CFTR EDN3 EDNRB FLNA GDNF
2 digestive/alimentary MP:0005381 10.18 CDX2 CFTR EDN3 EDNRB FLNA GDNF
3 cellular MP:0005384 10.17 CD8A CDX2 EDNRB FLNA GDNF KRT7
4 growth/size/body region MP:0005378 10.06 ACHE CDX2 CFTR EDNRB FLNA GDNF
5 endocrine/exocrine gland MP:0005379 10.02 RET SGO1 CDX2 CFTR EDNRB GDNF
6 mortality/aging MP:0010768 10 NOD2 RET SGO1 TWIST1 ACHE CD8A
7 immune system MP:0005387 9.96 CD8A CFTR EDNRB FLNA GDNF GUCY2C
8 muscle MP:0005369 9.5 ACHE EDNRB GDNF MTOR NRTN RET
9 nervous system MP:0003631 9.32 ACHE CD8A EDN3 EDNRB FLNA GDNF

Drugs & Therapeutics for Intestinal Obstruction

Drugs for Intestinal Obstruction (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 343)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Alvimopan Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 156053-89-3 5488548
2
Metronidazole Approved Phase 4,Phase 3,Not Applicable 443-48-1 4173
3
Naloxone Approved, Vet_approved Phase 4,Phase 3,Phase 1 465-65-6 5284596
4
Benzocaine Approved, Investigational Phase 4,Not Applicable 1994-09-7, 94-09-7 2337
5
Hyaluronic acid Approved, Vet_approved Phase 4,Phase 3,Not Applicable 9004-61-9 53477741
6
Celecoxib Approved, Investigational Phase 4,Phase 2 169590-42-5 2662
7
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
8
Ketorolac Approved Phase 4,Not Applicable 74103-06-3, 66635-83-4 3826
9
Morphine Approved, Investigational Phase 4,Not Applicable 57-27-2 5288826
10
Oxycodone Approved, Illicit, Investigational Phase 4,Not Applicable 76-42-6 5284603
11
Cefuroxime Approved Phase 4,Phase 3,Not Applicable 55268-75-2 5361202 5479529
12
Hydromorphone Approved, Illicit Phase 4,Not Applicable 466-99-9 5284570
13
Neostigmine Approved, Vet_approved Phase 4 59-99-4 4456
14
Dimenhydrinate Approved Phase 4 523-87-5 441281
15
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Not Applicable 437-38-7 3345
16
Somatostatin Approved, Investigational Phase 4,Phase 3,Phase 2 38916-34-6, 51110-01-1 53481605
17
Simethicone Approved Phase 4 8050-81-5
18
Magnesium citrate Approved Phase 4 3344-18-1
19
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
20
Ciprofloxacin Approved, Investigational Phase 4,Not Applicable 85721-33-1 2764
21
Infliximab Approved Phase 4 170277-31-3
22
Hydrocodone Approved, Illicit Phase 4 125-29-1 5284569
23
Methotrexate Approved Phase 4 1959-05-2, 59-05-2 126941
24
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
25
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
26
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
27
Methadone Approved Phase 4 76-99-3 4095
28
Acetaminophen Approved Phase 4 103-90-2 1983
29
Orphenadrine Approved Phase 4 83-98-7 4601
30
Adalimumab Approved Phase 4 331731-18-1 16219006
31
Azathioprine Approved Phase 4 446-86-6 2265
32
Oxytocin Approved, Vet_approved Phase 4 50-56-6 439302 53477758
33
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
34
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
35
Sulfamethazine Approved, Investigational, Vet_approved Phase 4 57-68-1 5327
36 tannic acid Approved, Nutraceutical Phase 4,Not Applicable
37
leucovorin Approved, Nutraceutical Phase 4,Phase 2,Phase 1,Not Applicable 58-05-9 143 6006
38
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
39
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
40 Mosapride Investigational Phase 4 112885-41-3
41 Analgesics Phase 4,Phase 1,Not Applicable
42 calcium channel blockers Phase 4,Not Applicable
43 Central Nervous System Depressants Phase 4,Phase 1,Phase 2,Not Applicable
44 Serotonin Agents Phase 4,Not Applicable
45 Narcotic Antagonists Phase 4,Phase 3,Phase 2,Phase 1
46 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
47 Narcotics Phase 4,Phase 3,Phase 2,Phase 1
48 Neurotransmitter Agents Phase 4,Phase 1,Phase 2,Not Applicable
49 Analgesics, Non-Narcotic Phase 4,Phase 1,Not Applicable
50 Anesthetics Phase 4,Phase 2,Not Applicable

Interventional clinical trials:

(show top 50) (show all 287)
# Name Status NCT ID Phase Drugs
1 Effect of Mosapride on Postoperative Ileus in Patients Undergoing Colorectal Surgery Unknown status NCT02056405 Phase 4 Mosapride;Placebo
2 Identifying the Effect of Somatostatin Treatment in Early Postoperative Simple Small Bowel Obstruction Completed NCT01082627 Phase 4 Somatostatin
3 (Gastrografin Use in Small Bowel Obstruction Caused by Adherences) Completed NCT00601809 Phase 4 Gastrografin®: G
4 Value of CT-Scan and Oral Gastrografin in the Management of Post Operative Small Bowel Obstruction Completed NCT00389116 Phase 4 gastrograffin;water
5 SurgiWrapTM to Reduce Soft Tissue Attachment & Incidence Early Post-Operative Bowel Obstruction in Colorectal Surgery Completed NCT00531739 Phase 4
6 The Effect of Guardix-solution for the Prevention of Postoperative Intestinal Adhesion and Intestinal Obstruction After Laparoscopic Pelvic Cavity Surgery Completed NCT02773251 Phase 4 hyaluronic acid-carboxymethylcellulose
7 Adult Patients Undergoing Open Colectomy MA402S23B303 Completed NCT01507246 Phase 4 IV morphine sulfate;EXPAREL (bupivacaine liposome injectable suspension)
8 Comparison of Burch Urethropexy and Mid-urethral Sling Performed Concomitantly With a Sacral Colpopexy Completed NCT00934999 Phase 4
9 GI-Reasons- A Trial Of GI Safety Of Celecoxib Compared With Non-Selective Nonsteroidal Antiinflammatory Drugs (NSAIDS) Completed NCT00373685 Phase 4 Celecoxib;Any commercially available NSAID with the indication for osteoarthritis
10 Pre-operative Bowel Preparation Prior to Minimally Invasive Sacral Colpopexy Completed NCT01805310 Phase 4
11 Effect of Simethicone on Postoperative Ileus in Patients Undergoing Colorectal Surgery Completed NCT02161367 Phase 4 Simethicone;Oral Suspending Vehicle
12 Effect of Sham Feeding on Postoperative Ileus After Elective Liver Transplantation Completed NCT01956643 Phase 4
13 Study of the Effect of Water Soluble Oral Contrast (Gastrografin) on Postoperative Ileus After Colorectal Surgery Completed NCT01440712 Phase 4 Gastrografin;physiological serum
14 A Study of Alvimopan for the Management of Postoperative Ileus in Participants Undergoing Radical Cystectomy Completed NCT00708201 Phase 4 Alvimopan;Placebo
15 A New Approach of Neostigmine in Unavoidable Post Operative Ileus Completed NCT00676377 Phase 4 Neostigmine;Saline
16 Efficacy and Tolerability of PEG-only Laxative for Fecal Impaction and Chronic Constipation in Children Completed NCT01592734 Phase 4 Polyethylene glycol with electrolytes
17 RCT: STARR vs Biofeedback Completed NCT00556283 Phase 4
18 Study of Stapled Transanal Rectal Resection (STARR) Surgery in Refractory Constipation Associated With Obstructive Defecation Syndrome (ODS) Completed NCT00256984 Phase 4
19 A proSpective Randomized Controlled Trial comParing infliximAb-antimetabolites Combination Therapy to Anti-metabolites monotheRapy and Infliximab monothErapy in Crohn's Disease Patients in Sustained Steroid-free Remission on Combination Therapy Recruiting NCT02177071 Phase 4 INFLIXIMAB;AZATHIOPRINE;MERCAPTOPURINE;Methotrexate
20 The Use of Oral Naloxone to Prevent Post Spinal Fusion Ileus Recruiting NCT03176316 Phase 4 Naloxone
21 Anti-inflammatory Effect of Pre-operative Stimulation of the Cholinergic Anti-Inflammatory Pathway Recruiting NCT02425774 Phase 4 Prucalopride;Placebo
22 Stricture Definition and Treatment (STRIDENT) Drug Therapy Study Recruiting NCT03220841 Phase 4 Adalimumab Injection;Thiopurine
23 Multimodal Narcotic Limited Perioperative Pain Control With Colorectal Surgery Recruiting NCT02958566 Phase 4 Acetaminophen;Gabapentin;Orphenadrine;Lidocaine;Marcaine;Ketamine;Methadone;Tramadol;Ketorolac;Morphine Sulfate;Fentanyl;Dilaudid;Hydrocodone-Acetaminophen Tab 5-325 MG;Morphine Sulfate;Fentanyl;Dilaudid;HYDROCODONE/ACETAMINOPHEN 5 Mg-325 Mg ORAL TABLET
24 Prophylaxis of Ileostomy Closure Site Hernia by Placing Mesh Recruiting NCT02226887 Phase 4
25 Continued Versus Discontinued Oxytocin Stimulation of Labour Recruiting NCT02553226 Phase 4 Oxytocin;Placebo
26 Parenteral Antibiotics Compared to Combination of Oral and Parenteral Antibiotics in Colorectal Surgery Prophylaxis Recruiting NCT02505581 Phase 4 Extra dosage - cefuroxime (750mg) I.V;Cefuroxime 750mg oral;Metronidazole 250mg oral;Metronidazole 1,5gr Intravenous;Cefuroxime 1g Intravenous
27 Potential Mechanisms for Intussusception After Rotavirus Vaccine-Pilot Study Active, not recruiting NCT02542462 Phase 4 Rotarix®,;Rotarix®, with other routine vaccines;RotaTeq®,;RotaTeq®, with other routine vaccines
28 Enhanced Algorithm for Crohn's Treatment Incorporating Early Combination Therapy Enrolling by invitation NCT01698307 Phase 4
29 Deep Versus Moderate Neuromuscular Blockade During Laparoscopic Surgery Enrolling by invitation NCT02812186 Phase 4 Rocuronium
30 The Use of Gastrografin to Help Alleviate Bowel Obstruction in Gastroschisis Patients. Not yet recruiting NCT03334578 Phase 4 Gastrografin
31 Alvimopan Use in Polytraumatized Patients Not yet recruiting NCT03068975 Phase 4 Alvimopan;Placebo
32 A Health Economic Trial in Adult Patients Undergoing Laparoscopic Colectomy Terminated NCT02058290 Phase 4 IV morphine sulfate or Sponsor-approved equivalent;EXPAREL
33 A Health Economic Trial in Adult Patients Undergoing Open Colectomy MA402S23B302 Terminated NCT01507233 Phase 4 IV morphine sulfate;EXPAREL (bupivacaine liposome injectable suspension)
34 A Health Economic Trial in Adult Patients Undergoing Open Colectomy MA402S23B301 Terminated NCT01507220 Phase 4 morphine sulfate;bupivacaine liposome extended-release injectable suspension
35 Naloxone in Treating Constipation in Patients Who Are Receiving Opioids for Chronic Pain Unknown status NCT00020605 Phase 3 naloxone hydrochloride
36 Endolaparoscopic Versus Immediate Surgery for Obstructing Colorectal Cancers Unknown status NCT00164879 Phase 3
37 Bariatric Arterial Embolization for Morbid Obesity Unknown status NCT02786108 Phase 3
38 Study of Dexamethasone-Allantoin-Metronidazole (DAM) Solution in the Treatment of Post-Operative Ileus (POI) Unknown status NCT01863407 Phase 3 DAM;Normal Saline
39 Alvimopan as Rescue in Post op Ileus Unknown status NCT02742181 Phase 3 Alvimopan
40 Electroacupuncture Versus Fast-track Perioperative Program for Laparoscopic Colorectal Surgery Unknown status NCT02059603 Phase 3
41 Observation, Combination Chemotherapy, Radiation Therapy, and/or Autologous Stem Cell Transplant in Treating Young Patients With Neuroblastoma Unknown status NCT00410631 Phase 3 carboplatin;cisplatin;cyclophosphamide;dacarbazine;doxorubicin hydrochloride;etoposide phosphate;ifosfamide;isotretinoin;melphalan;topotecan hydrochloride;vincristine sulfate;vindesine
42 Outcome of Palliative Management of Malignant Large Bowel Obstruction w/Colorectal Stents or Surgery Completed NCT00140868 Phase 3
43 Bioresorbable Membrane to Reduce Postoperative Small Bowel Obstruction Completed NCT00529412 Phase 3
44 Efficacy and Safety of Lanreotide Microparticles as Palliative Treatment in Peritoneal Carcinomatosis Completed NCT00216372 Phase 3 Lanreotide (microparticle formulation)
45 Randomized Trial of Colonic Stents as a Bridge to Surgery Completed NCT00758186 Phase 3
46 Randomized Control Trial on Seprafilm and Guardix in Preventing Ileus Completed NCT02168426 Phase 3
47 Effects of Delayed Enteral Nutrition on Inflammatory Responses and Immune Function Competence in Critically Ill Patients With Prolonged Fasting Completed NCT01834430 Phase 3
48 Antibiotic Prophylaxis in the Prevention of Surgical Site Infections After Selected Urgent Abdominal Surgical Procedures Completed NCT01524081 Phase 3 Metronidazole, Cefuroxime;Amoxicillin (+ clavulanic acid) and Fluconazole;Placebo;Placebo
49 Gastrografin in Postoperative Ileus Completed NCT01648972 Phase 2, Phase 3 Gastrografin;Placebo
50 Pertuzumab in Platinum-Resistant Low Human Epidermal Growth Factor Receptor 3 (HER3) Messenger Ribonucleic Acid (mRNA) Epithelial Ovarian Cancer (PENELOPE) Completed NCT01684878 Phase 3 Gemcitabine (Chemotherapy);Paclitaxel (Chemotherapy);Pertuzumab;Placebo;Topotecan (Chemotherapy)

Search NIH Clinical Center for Intestinal Obstruction

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: intestinal obstruction

Genetic Tests for Intestinal Obstruction

Genetic tests related to Intestinal Obstruction:

# Genetic test Affiliating Genes
1 Intestinal Obstruction 29

Anatomical Context for Intestinal Obstruction

MalaCards organs/tissues related to Intestinal Obstruction:

41
Colon, Small Intestine, Kidney, Liver, Spleen, Lung, Bone

Publications for Intestinal Obstruction

Articles related to Intestinal Obstruction:

(show top 50) (show all 789)
# Title Authors Year
1
Jejunojejunal intussusception: an unusual case of postoperative intestinal obstruction. ( 29909685 )
2018
2
Giant granadilla's seeds phytobezoar rectal impactation: a very unusual case of intestinal obstruction. ( 29437811 )
2018
3
Neonatal Intestinal Obstruction Syndrome. ( 29750290 )
2018
4
Adhesive intestinal obstruction increases the risk of intestinal perforation in peritoneal dialysis patients: a case report. ( 29954334 )
2018
5
Acute intestinal obstruction due to extrinsic compression by previa myoma and ectopic pregnancy: a case report. ( 29335010 )
2018
6
Role of bowel suspension technique to prevent early intestinal obstruction after radical cystectomy with ileal orthotopic neobladder: A retrospective cohort study. ( 29723678 )
2018
7
Interventions for preventing distal intestinal obstruction syndrome (DIOS) in cystic fibrosis. ( 29894558 )
2018
8
Migrated embolization coil causes intestinal obstruction. ( 29725660 )
2018
9
Gastric inflammatory fibroid polyp tumor with acute intestinal obstruction-Vanek's tumor can mimick a giant gastrointestinal stromal tumor or a gastric lymphoma. ( 29682464 )
2018
10
Small intestinal obstruction due to the metastasis of intrahepatic cholangiocarcinoma: A case report. ( 29561438 )
2018
11
A Masquerading and Unconventional Cause of Dynamic Intestinal Obstruction: Strangulated Obturator Hernia. ( 29607272 )
2018
12
Endoscopically Assisted Transcervical Esophagogastric Tube Placement for Nonoperative Intestinal Obstruction: An Alternative to PEG Placement. ( 29712576 )
2018
13
Endometrioma of the sigmoid colon presenting with intestinal obstruction. ( 29199174 )
2018
14
Intestinal obstruction - Not everything is as it seems. ( 29650432 )
2018
15
A case of canine intestinal obstruction due to ingestion of a superabsorbent polymer bead. ( 29315580 )
2018
16
Death of a Female Prostitute Due to Intestinal Obstruction by an Unknown Substance. ( 29768663 )
2018
17
Comparisons of the surgical outcomes and medical costs between transferred and directly admitted patients diagnosed with intestinal obstruction in an American tertiary referral center. ( 29679151 )
2018
18
Caecal duplication cyst: a rare cause of neonatal intestinal obstruction. ( 29326372 )
2018
19
Sub-acute intestinal obstruction - a rare complication of Plasmodium falciparum malaria in an adult: a case report. ( 29966528 )
2018
20
The Turning Point for Morphomechanical Remodeling During Complete Intestinal Obstruction in Rats Occurs After 12-24A h. ( 29427158 )
2018
21
Intestinal obstruction secondary to hypogastric artery aneurysm. ( 29525121 )
2018
22
An unusual cause of gastrointestinal bleeding and intestinal obstruction. ( 29755023 )
2018
23
Time-course evaluation of intestinal structural disorders in a porcine model of intra-abdominal hypertension by mechanical intestinal obstruction. ( 29357386 )
2018
24
Intraoperative intraluminal injection of N-acetylcysteine allowing treatment of distal intestinal obstruction syndrome without the need for enterotomy. ( 29769187 )
2018
25
Intestinal obstruction caused by a strangulating adnexa: a rare complication of ovarian sparing hysterectomy. ( 29444792 )
2018
26
Intestinal obstruction caused by desmoid tumours: a review of the literature. ( 29760935 )
2018
27
Hydrocephalus recurrence and intestinal obstruction due to giant CSF pseudocyst. ( 29330586 )
2018
28
Severe intestinal obstruction due to Strongyloides stercoralis in a pregnant woman. ( 28651833 )
2017
29
Antenatal Bartter syndrome presenting with vomiting and constipation mimicking subacute intestinal obstruction in a 20-day-old neonate. ( 29141924 )
2017
30
Long-term intestinal obstruction sequelae and growth in children with cystic fibrosis operated for meconium ileus: expectancies and surprises. ( 29224788 )
2017
31
Large Meckel's Diverticulum and Dilated Adjacent Small Intestine Presenting With Intestinal Obstruction. ( 28899672 )
2017
32
Abdominal cocoon - A rare etiology of intestinal obstruction. ( 29417033 )
2017
33
Laparoscopic resection for Meckel's diverticulum causing intestinal obstruction. ( 28944341 )
2017
34
Effects of herbal medicine Sijunzi decoction on rabbits after relieving intestinal obstruction. ( 28953987 )
2017
35
Neonatal intestinal obstruction associated with situs inversus totalis: two case reports and a review of the literature. ( 28918753 )
2017
36
Peritoneal encapsulationA -A an unexpected cause of acute intestinal obstruction. ( 28688775 )
2017
37
Inverted Meckel's Diverticulum: Rare Etiology of an Intestinal Obstruction. ( 29308334 )
2017
38
Meckel's Diverticulum Enterolith: An Extremely Rare Cause of Intestinal Obstruction. ( 28571210 )
2017
39
Intestinal Obstruction by Giant Meckel's Diverticulum. ( 29255748 )
2017
40
Acute intestinal obstruction due to metastatic lung cancer-case report. ( 28458837 )
2017
41
Management of a large cystic lymphangioma causing intestinal obstruction. ( 28477401 )
2017
42
Intestinal obstruction due to kaposiform hemangioendothelioma in a 1-month-old infant: A case report. ( 28906349 )
2017
43
Intestinal obstruction caused by appendiceal knot. ( 29196118 )
2017
44
Intestinal Obstruction in Early Neonatal Period: A 3-Year Review Of Admitted Cases from a Tertiary Hospital in Ethiopia. ( 29217941 )
2017
45
Superior mesenteric artery syndrome: an uncommon cause of intestinal obstruction. ( 28100055 )
2017
46
A retrospective audit on usage of Diatrizoate Meglumine (Gastrografin(Ar)) for intestinal obstruction or constipation in patients with advanced neoplasms. ( 28805119 )
2017
47
Combined use of single-balloon enteroscope and colonoscope for self-expandable metal stent placement in patients with malignant small intestinal obstruction: a single-center comparative clinical observation. ( 28585148 )
2017
48
Abdominal Plain Radiograph in Neonatal Intestinal Obstruction. ( 28083492 )
2017
49
Distal intestinal obstruction syndrome and colonic pathologies in cystic fibrosis. ( 28067560 )
2017
50
Kawasaki Disease Presenting as Acute Intestinal Obstruction. ( 28694577 )
2017

Variations for Intestinal Obstruction

Expression for Intestinal Obstruction

Search GEO for disease gene expression data for Intestinal Obstruction.

Pathways for Intestinal Obstruction

Pathways related to Intestinal Obstruction according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.88 GDNF NRTN RET

GO Terms for Intestinal Obstruction

Biological processes related to Intestinal Obstruction according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.85 EDNRB FLNA GDNF RET TWIST1
2 nervous system development GO:0007399 9.83 ACHE EDNRB GDNF NRTN RET
3 positive regulation of cell proliferation GO:0008284 9.8 CDX2 EDN3 EDNRB GDNF NOD2
4 response to pain GO:0048265 9.54 EDNRB RET
5 positive regulation of cell differentiation GO:0045597 9.54 CDX2 EDN3 GDNF
6 mRNA stabilization GO:0048255 9.52 GDNF MTOR
7 melanocyte differentiation GO:0030318 9.51 EDN3 EDNRB
8 vasoconstriction GO:0042310 9.49 EDN3 EDNRB
9 positive regulation of potassium ion transmembrane transport GO:1901381 9.48 EDN3 FLNA
10 positive regulation of neuron maturation GO:0014042 9.32 MTOR RET
11 vein smooth muscle contraction GO:0014826 9.26 EDN3 EDNRB
12 posterior midgut development GO:0007497 9.16 EDNRB RET
13 enteric nervous system development GO:0048484 9.13 EDNRB GDNF RET
14 neural crest cell migration GO:0001755 9.02 EDN3 EDNRB GDNF NRTN RET

Molecular functions related to Intestinal Obstruction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Ras guanyl-nucleotide exchange factor activity GO:0005088 8.8 GDNF NRTN RET

Sources for Intestinal Obstruction

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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