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MCID: INT070
MIFTS: 53

Intestinal Obstruction

Categories: Fetal diseases, Gastrointestinal diseases, Genetic diseases, Neuronal diseases, Rare diseases
Genes Tissues Related diseases Publications Symptoms & Phenotypes Drugs
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Aliases & Classifications for Intestinal Obstruction

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MalaCards integrated aliases for Intestinal Obstruction:

Name: Intestinal Obstruction 12 29 55 43 44 15 73

Classifications:

MalaCards categories:
Global: Fetal diseases Rare diseases Genetic diseases
Anatomical: Gastrointestinal diseases Neuronal diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:8437
ICD9CM 35 560.9
MeSH 44 D007415
NCIt 50 C9175
SNOMED-CT 68 81060008
UMLS 73 C0021843
Sources

Summaries for Intestinal Obstruction

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MedlinePlus : 43 An intestinal obstruction occurs when food or stool cannot move through the intestines. The obstruction can be complete or partial. There are many causes. The most common are adhesions, hernias, cancers, and certain medicines. Symptoms include Severe abdominal pain or cramping Vomiting Bloating Loud bowel sounds Swelling of the abdomen Inability to pass gas Constipation A complete intestinal obstruction is a medical emergency. It often requires surgery. NIH: National Institute of Diabetes and Digestive and Kidney Diseases

MalaCards based summary : Intestinal Obstruction is related to intestinal pseudo-obstruction and hirschsprung disease 1, and has symptoms including nausea and vomiting, constipation and abdominal pain. An important gene associated with Intestinal Obstruction is GDNF (Glial Cell Derived Neurotrophic Factor). The drugs Alvimopan and Naloxone have been mentioned in the context of this disorder. Affiliated tissues include colon, small intestine and kidney, and related phenotypes are behavior/neurological and digestive/alimentary

Sources

Related Diseases for Intestinal Obstruction

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Diseases in the Intestinal Obstruction family:

Intestinal Pseudo-Obstruction

Diseases related to Intestinal Obstruction via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 352)
# Related Disease Score Top Affiliating Genes
1 intestinal pseudo-obstruction 32.2 EDNRB FLNA RET SGO1
2 hirschsprung disease 1 31.6 ACHE BLVRB EDN3 EDNRB GDNF NRTN
3 hypoganglionosis 31.5 ACHE BLVRB GDNF RET
4 intestinal disease 30.7 CDX2 EDNRB NOD2
5 constipation 29.8 EDN3 EDNRB FLNA GDNF MLN RET
6 cystic teratoma 29.8 CDX2 KRT20 KRT7
7 pseudomyxoma peritonei 29.8 CDX2 KRT20 KRT7
8 intrahepatic cholangiocarcinoma 29.8 CDX2 KRT20 KRT7
9 jejunal adenocarcinoma 29.6 CDX2 KRT20 KRT7
10 mucinous adenocarcinoma 29.6 CDX2 KRT20 KRT7
11 horseshoe kidney 29.6 CDX2 KRT20 KRT7
12 megacolon 29.6 ACHE EDN3 EDNRB GDNF NRTN RET
13 cholangiocarcinoma 29.5 CDX2 KRT20 KRT7 MTOR
14 intestinal perforation 29.5 KRT7 NOD2
15 autosomal dominant polycystic kidney disease 29.3 CFTR EDNRB MTOR
16 meconium ileus 12.2
17 peritonitis 11.3
18 ascaris lumbricoides infection 11.3
19 wandering spleen 11.3
20 visceral myopathy 11.3
21 duodenal atresia 11.3
22 hirschsprung disease 2 11.3
23 congenital chloride diarrhea 11.3
24 intestinal pseudoobstruction, neuronal, chronic idiopathic, x-linked 11.1
25 juvenile polyposis syndrome 11.0
26 gastrointestinal defects and immunodeficiency syndrome 11.0
27 hirschsprung disease 3 11.0
28 hirschsprung disease 4 11.0
29 chronic atrial and intestinal dysrhythmia 11.0
30 diphyllobothriasis 11.0
31 fasciolopsiasis 11.0
32 actg2-related disorders 11.0
33 abdominal cystic lymphangioma 11.0
34 desmoid tumor 11.0
35 intussusception 10.8
36 intestinal volvulus 10.7
37 paralytic ileus 10.7
38 cystic fibrosis 10.4
39 medullary sponge kidney 10.3 GDNF RET
40 waardenburg syndrome type 4 10.3 EDN3 EDNRB
41 oligomeganephronia 10.3 GDNF RET
42 ovarian germ cell teratoma 10.3 KRT7 RET
43 multiple endocrine neoplasia, type iib 10.2 EDNRB GDNF RET
44 ovarian germ cell cancer 10.2 KRT7 RET
45 ovary neuroendocrine neoplasm 10.2 CDX2 KRT7
46 waardenburg syndrome, type 4a 10.2 EDN3 EDNRB RET
47 mucinous adenofibroma 10.2 CDX2 KRT7
48 waardenburg syndrome, type 4b 10.2 EDN3 EDNRB
49 anus adenocarcinoma 10.2 CDX2 KRT7
50 cystic basal cell carcinoma 10.2 KRT20 KRT7

Comorbidity relations with Intestinal Obstruction via Phenotypic Disease Network (PDN): (show top 50) (show all 59)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Acute Pancreatitis
Acute Vascular Insufficiency of Intestine Anxiety
Ascending Colon Cancer Bronchitis
Candidiasis Cecal Benign Neoplasm
Cervical Cancer Chronic Intestinal Vascular Insufficiency
Chronic Kidney Failure Chronic Myocardial Ischemia
Chylomicron Retention Disease Colorectal Cancer
Crohn's Disease Decubitus Ulcer
Deficiency Anemia Descending Colon Cancer
Enterovesical Fistula Esophageal Disease
Esophagitis Familial Atrial Fibrillation
Gastric Cancer Gastrointestinal System Cancer
Generalized Atherosclerosis Heart Disease
Hepatic Flexure Cancer Hydronephrosis
Hypertension, Essential Hypothyroidism
Inflammatory Bowel Disease 1 Intestinal Disease
Intestinal Perforation Intestinal Volvulus
Iron Deficiency Anemia Irritable Bowel Syndrome
Jejunal Cancer Kidney Disease
Marasmus Neutropenia
Osteoporosis Ovarian Cancer
Pancreatic Cancer Pancreatitis, Hereditary
Paralytic Ileus Peritonitis
Postgastrectomy Syndrome Protein-Energy Malnutrition

Graphical network of the top 20 diseases related to Intestinal Obstruction:



Diseases related to Intestinal Obstruction
Sources

Symptoms & Phenotypes for Intestinal Obstruction

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UMLS symptoms related to Intestinal Obstruction:


nausea and vomiting, constipation, abdominal pain, diarrhea, icterus, dyspepsia, heartburn, gastrointestinal gas

MGI Mouse Phenotypes related to Intestinal Obstruction:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.21 ACHE CFTR EDN3 EDNRB FLNA GDNF
2 digestive/alimentary MP:0005381 10.15 CDX2 CFTR EDN3 EDNRB FLNA GDNF
3 cellular MP:0005384 10.1 CDX2 EDNRB FLNA GDNF KRT7 MTOR
4 growth/size/body region MP:0005378 10 ACHE CDX2 CFTR EDNRB FLNA GDNF
5 homeostasis/metabolism MP:0005376 9.93 ACHE BLVRB CDX2 CFTR EDNRB FLNA
6 endocrine/exocrine gland MP:0005379 9.92 CDX2 CFTR EDNRB GDNF MTOR NRTN
7 mortality/aging MP:0010768 9.77 ACHE CDX2 CFTR EDN3 EDNRB FLNA
8 muscle MP:0005369 9.17 ACHE EDNRB GDNF MTOR NRTN RET
Sources

Drugs & Therapeutics for Intestinal Obstruction

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Drugs for Intestinal Obstruction (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 346)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Alvimopan Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 156053-89-3 5488548
2
Naloxone Approved, Vet_approved Phase 4,Phase 3,Phase 1 465-65-6 5284596
3
Metronidazole Approved Phase 4,Phase 3,Not Applicable 443-48-1 4173
4
Benzocaine Approved, Investigational Phase 4,Not Applicable 94-09-7, 1994-09-7 2337
5 tannic acid Approved Phase 4,Not Applicable
6
Somatostatin Approved, Investigational Phase 4,Phase 3,Phase 2 51110-01-1, 38916-34-6 53481605
7
Hyaluronic acid Approved, Vet_approved Phase 4,Phase 3,Not Applicable 9004-61-9 53477741
8
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
9
Morphine Approved, Investigational Phase 4,Not Applicable 57-27-2 5288826
10
Ketorolac Approved Phase 4,Not Applicable 66635-83-4, 74103-06-3 3826
11
Celecoxib Approved, Investigational Phase 4 169590-42-5 2662
12
Magnesium citrate Approved Phase 4 3344-18-1
13
Simethicone Approved Phase 4 8050-81-5
14
Dimenhydrinate Approved Phase 4 523-87-5 441281
15
Neostigmine Approved, Vet_approved Phase 4 59-99-4 4456
16
leucovorin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 58-05-9 6006 143
17
Oxycodone Approved, Illicit, Investigational Phase 4,Not Applicable 76-42-6 5284603
18
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Not Applicable 437-38-7 3345
19
Hydromorphone Approved, Illicit Phase 4,Not Applicable 466-99-9 5284570
20
Cefuroxime Approved Phase 4,Phase 3,Not Applicable 55268-75-2 5361202 5479529
21
Azathioprine Approved Phase 4 446-86-6 2265
22
Methotrexate Approved Phase 4 59-05-2, 1959-05-2 126941
23
Infliximab Approved Phase 4 170277-31-3
24
Adalimumab Approved Phase 4 331731-18-1 16219006
25
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
26
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
27
Orphenadrine Approved Phase 4 83-98-7 4601
28
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
29
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
30
Hydrocodone Approved, Illicit, Investigational Phase 4 125-29-1 5284569
31
Acetaminophen Approved Phase 4 103-90-2 1983
32
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
33
Methadone Approved Phase 4 76-99-3 4095
34
Oxytocin Approved, Vet_approved Phase 4 50-56-6 439302 53477758
35
Ciprofloxacin Approved, Investigational Phase 4,Not Applicable 85721-33-1 2764
36
Sulfamethazine Approved, Investigational, Vet_approved Phase 4 57-68-1 5327
37
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
38
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4,Not Applicable 77-92-9 311
39
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
40 Mosapride Investigational Phase 4 112885-41-3
41 Neurotransmitter Agents Phase 4,Phase 1,Phase 2,Not Applicable
42 Serotonin Agents Phase 4,Not Applicable
43 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
44 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
45 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
46 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
47 Immunologic Factors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
48 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Not Applicable
49 Analgesics Phase 4,Phase 1,Not Applicable
50 Anesthetics, Local Phase 4

Interventional clinical trials:

(show top 50) (show all 315)
# Name Status NCT ID Phase Drugs
1 Effect of Mosapride on Postoperative Ileus in Patients Undergoing Colorectal Surgery Unknown status NCT02056405 Phase 4 Mosapride;Placebo
2 Identifying the Effect of Somatostatin Treatment in Early Postoperative Simple Small Bowel Obstruction Completed NCT01082627 Phase 4 Somatostatin
3 (Gastrografin Use in Small Bowel Obstruction Caused by Adherences) Completed NCT00601809 Phase 4 Gastrografin®: G
4 Value of CT-Scan and Oral Gastrografin in the Management of Post Operative Small Bowel Obstruction Completed NCT00389116 Phase 4 gastrograffin;water
5 SurgiWrapTM to Reduce Soft Tissue Attachment & Incidence Early Post-Operative Bowel Obstruction in Colorectal Surgery Completed NCT00531739 Phase 4
6 The Effect of Guardix-solution for the Prevention of Postoperative Intestinal Adhesion and Intestinal Obstruction After Laparoscopic Pelvic Cavity Surgery Completed NCT02773251 Phase 4 hyaluronic acid-carboxymethylcellulose
7 Adult Patients Undergoing Open Colectomy MA402S23B303 Completed NCT01507246 Phase 4 IV morphine sulfate;EXPAREL (bupivacaine liposome injectable suspension)
8 Comparison of Burch Urethropexy and Mid-urethral Sling Performed Concomitantly With a Sacral Colpopexy Completed NCT00934999 Phase 4
9 GI-Reasons- A Trial Of GI Safety Of Celecoxib Compared With Non-Selective Nonsteroidal Antiinflammatory Drugs (NSAIDS) Completed NCT00373685 Phase 4 Celecoxib;Any commercially available NSAID with the indication for osteoarthritis
10 Pre-operative Bowel Preparation Prior to Minimally Invasive Sacral Colpopexy Completed NCT01805310 Phase 4
11 Effect of Simethicone on Postoperative Ileus in Patients Undergoing Colorectal Surgery Completed NCT02161367 Phase 4 Simethicone;Oral Suspending Vehicle
12 Effect of Sham Feeding on Postoperative Ileus After Elective Liver Transplantation Completed NCT01956643 Phase 4
13 Study of the Effect of Water Soluble Oral Contrast (Gastrografin) on Postoperative Ileus After Colorectal Surgery Completed NCT01440712 Phase 4 Gastrografin;physiological serum
14 A Study of Alvimopan for the Management of Postoperative Ileus in Participants Undergoing Radical Cystectomy Completed NCT00708201 Phase 4 Alvimopan;Placebo
15 A New Approach of Neostigmine in Unavoidable Post Operative Ileus Completed NCT00676377 Phase 4 Neostigmine;Saline
16 Efficacy and Tolerability of PEG-only Laxative for Fecal Impaction and Chronic Constipation in Children Completed NCT01592734 Phase 4 Polyethylene glycol with electrolytes
17 Potential Mechanisms for Intussusception After Rotavirus Vaccine-Pilot Study Completed NCT02542462 Phase 4 Rotarix®,;Rotarix®, with other routine vaccines;RotaTeq®,;RotaTeq®, with other routine vaccines
18 RCT: STARR vs Biofeedback Completed NCT00556283 Phase 4
19 Study of Stapled Transanal Rectal Resection (STARR) Surgery in Refractory Constipation Associated With Obstructive Defecation Syndrome (ODS) Completed NCT00256984 Phase 4
20 The Use of Gastrografin to Help Alleviate Bowel Obstruction in Gastroschisis Patients. Recruiting NCT03334578 Phase 4 Gastrografin
21 A proSpective Randomized Controlled Trial comParing infliximAb-antimetabolites Combination Therapy to Anti-metabolites monotheRapy and Infliximab monothErapy in Crohn's Disease Patients in Sustained Steroid-free Remission on Combination Therapy Recruiting NCT02177071 Phase 4 INFLIXIMAB;AZATHIOPRINE;MERCAPTOPURINE;Methotrexate
22 The Use of Oral Naloxone to Prevent Post Spinal Fusion Ileus Recruiting NCT03176316 Phase 4 Naloxone
23 Anti-inflammatory Effect of Pre-operative Stimulation of the Cholinergic Anti-Inflammatory Pathway Recruiting NCT02425774 Phase 4 Prucalopride;Placebo
24 Stricture Definition and Treatment (STRIDENT) Drug Therapy Study Recruiting NCT03220841 Phase 4 Adalimumab Injection;Thiopurine
25 Multimodal Narcotic Limited Perioperative Pain Control With Colorectal Surgery Recruiting NCT02958566 Phase 4 Acetaminophen;Gabapentin;Orphenadrine;Lidocaine;Marcaine;Ketamine;Methadone;Tramadol;Ketorolac;Morphine Sulfate;Fentanyl;Dilaudid;Hydrocodone-Acetaminophen Tab 5-325 MG;Morphine Sulfate;Fentanyl;Dilaudid;HYDROCODONE/ACETAMINOPHEN 5 Mg-325 Mg ORAL TABLET
26 Prophylaxis of Ileostomy Closure Site Hernia by Placing Mesh Recruiting NCT02226887 Phase 4
27 Continued Versus Discontinued Oxytocin Stimulation of Labour Recruiting NCT02553226 Phase 4 Oxytocin;Placebo
28 Parenteral Antibiotics Compared to Combination of Oral and Parenteral Antibiotics in Colorectal Surgery Prophylaxis Recruiting NCT02505581 Phase 4 Extra dosage - cefuroxime (750mg) I.V;Cefuroxime 750mg oral;Metronidazole 250mg oral;Metronidazole 1,5gr Intravenous;Cefuroxime 1g Intravenous
29 Enhanced Algorithm for Crohn's Treatment Incorporating Early Combination Therapy Active, not recruiting NCT01698307 Phase 4
30 Deep Versus Moderate Neuromuscular Blockade During Laparoscopic Surgery Enrolling by invitation NCT02812186 Phase 4 Rocuronium
31 Standard Bupivacaine vs Liposomal Bupivacaine in Colorectal Patients Enrolling by invitation NCT03638635 Phase 4 Bupivacaine;Bupivacaine liposome
32 Alvimopan Use in Polytraumatized Patients Not yet recruiting NCT03068975 Phase 4 Alvimopan;Placebo
33 A Health Economic Trial in Adult Patients Undergoing Laparoscopic Colectomy Terminated NCT02058290 Phase 4 IV morphine sulfate or Sponsor-approved equivalent;EXPAREL
34 A Health Economic Trial in Adult Patients Undergoing Open Colectomy MA402S23B302 Terminated NCT01507233 Phase 4 IV morphine sulfate;EXPAREL (bupivacaine liposome injectable suspension)
35 A Health Economic Trial in Adult Patients Undergoing Open Colectomy MA402S23B301 Terminated NCT01507220 Phase 4 morphine sulfate;bupivacaine liposome extended-release injectable suspension
36 Naloxone in Treating Constipation in Patients Who Are Receiving Opioids for Chronic Pain Unknown status NCT00020605 Phase 3 naloxone hydrochloride
37 Endolaparoscopic Versus Immediate Surgery for Obstructing Colorectal Cancers Unknown status NCT00164879 Phase 3
38 Bariatric Arterial Embolization for Morbid Obesity Unknown status NCT02786108 Phase 3
39 Study of Dexamethasone-Allantoin-Metronidazole (DAM) Solution in the Treatment of Post-Operative Ileus (POI) Unknown status NCT01863407 Phase 3 DAM;Normal Saline
40 Alvimopan as Rescue in Post op Ileus Unknown status NCT02742181 Phase 3 Alvimopan
41 Electroacupuncture Versus Fast-track Perioperative Program for Laparoscopic Colorectal Surgery Unknown status NCT02059603 Phase 3
42 Observation, Combination Chemotherapy, Radiation Therapy, and/or Autologous Stem Cell Transplant in Treating Young Patients With Neuroblastoma Unknown status NCT00410631 Phase 3 carboplatin;cisplatin;cyclophosphamide;dacarbazine;doxorubicin hydrochloride;etoposide phosphate;ifosfamide;isotretinoin;melphalan;topotecan hydrochloride;vincristine sulfate;vindesine
43 Posterior Compression Distraction Reduction （CDR）Technique in the Treatment of BI-AAD Unknown status NCT02463630 Phase 3
44 Outcome of Palliative Management of Malignant Large Bowel Obstruction w/Colorectal Stents or Surgery Completed NCT00140868 Phase 3
45 Bioresorbable Membrane to Reduce Postoperative Small Bowel Obstruction Completed NCT00529412 Phase 3
46 Efficacy and Safety of Lanreotide Microparticles as Palliative Treatment in Peritoneal Carcinomatosis Completed NCT00216372 Phase 3 Lanreotide (microparticle formulation)
47 Randomized Trial of Colonic Stents as a Bridge to Surgery Completed NCT00758186 Phase 3
48 Randomized Control Trial on Seprafilm and Guardix in Preventing Ileus Completed NCT02168426 Phase 3
49 Effects of Delayed Enteral Nutrition on Inflammatory Responses and Immune Function Competence in Critically Ill Patients With Prolonged Fasting Completed NCT01834430 Phase 3
50 Antibiotic Prophylaxis in the Prevention of Surgical Site Infections After Selected Urgent Abdominal Surgical Procedures Completed NCT01524081 Phase 3 Metronidazole, Cefuroxime;Amoxicillin (+ clavulanic acid) and Fluconazole;Placebo;Placebo

Search NIH Clinical Center for Intestinal Obstruction

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: intestinal obstruction

Sources

Genetic Tests for Intestinal Obstruction

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Genetic tests related to Intestinal Obstruction:

# Genetic test Affiliating Genes
1 Intestinal Obstruction 29
Sources

Anatomical Context for Intestinal Obstruction

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MalaCards organs/tissues related to Intestinal Obstruction:

41
Colon, Small Intestine, Kidney, Lung, Liver, Pancreas, Appendix
Sources

Publications for Intestinal Obstruction

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Articles related to Intestinal Obstruction:

(show top 50) (show all 1125)
# Title Authors Year
1
Jejunojejunal intussusception: an unusual case of postoperative intestinal obstruction. ( 29909685 )
2018
2
Giant granadilla's seeds phytobezoar rectal impactation: a very unusual case of intestinal obstruction. ( 29437811 )
2018
3
Neonatal Intestinal Obstruction Syndrome. ( 29750290 )
2018
4
Adhesive intestinal obstruction increases the risk of intestinal perforation in peritoneal dialysis patients: a case report. ( 29954334 )
2018
5
Acute intestinal obstruction due to extrinsic compression by previa myoma and ectopic pregnancy: a case report. ( 29335010 )
2018
6
Role of bowel suspension technique to prevent early intestinal obstruction after radical cystectomy with ileal orthotopic neobladder: A retrospective cohort study. ( 29723678 )
2018
7
Interventions for preventing distal intestinal obstruction syndrome (DIOS) in cystic fibrosis. ( 29894558 )
2018
8
Migrated embolization coil causes intestinal obstruction. ( 29725660 )
2018
9
Gastric inflammatory fibroid polyp tumor with acute intestinal obstruction-Vanek's tumor can mimick a giant gastrointestinal stromal tumor or a gastric lymphoma. ( 29682464 )
2018
10
Small intestinal obstruction due to the metastasis of intrahepatic cholangiocarcinoma: A case report. ( 29561438 )
2018
11
A Masquerading and Unconventional Cause of Dynamic Intestinal Obstruction: Strangulated Obturator Hernia. ( 29607272 )
2018
12
Endoscopically Assisted Transcervical Esophagogastric Tube Placement for Nonoperative Intestinal Obstruction: An Alternative to PEG Placement. ( 29712576 )
2018
13
Endometrioma of the sigmoid colon presenting with intestinal obstruction. ( 29199174 )
2018
14
Intestinal obstruction - Not everything is as it seems. ( 29650432 )
2018
15
A case of canine intestinal obstruction due to ingestion of a superabsorbent polymer bead. ( 29315580 )
2018
16
Death of a Female Prostitute Due to Intestinal Obstruction by an Unknown Substance. ( 29768663 )
2018
17
Comparisons of the surgical outcomes and medical costs between transferred and directly admitted patients diagnosed with intestinal obstruction in an American tertiary referral center. ( 29679151 )
2018
18
Caecal duplication cyst: a rare cause of neonatal intestinal obstruction. ( 29326372 )
2018
19
Sub-acute intestinal obstruction - a rare complication of Plasmodium falciparum malaria in an adult: a case report. ( 29966528 )
2018
20
The Turning Point for Morphomechanical Remodeling During Complete Intestinal Obstruction in Rats Occurs After 12-24A h. ( 29427158 )
2018
21
Intestinal obstruction secondary to hypogastric artery aneurysm. ( 29525121 )
2018
22
An unusual cause of gastrointestinal bleeding and intestinal obstruction. ( 29755023 )
2018
23
Time-course evaluation of intestinal structural disorders in a porcine model of intra-abdominal hypertension by mechanical intestinal obstruction. ( 29357386 )
2018
24
Intraoperative intraluminal injection of N-acetylcysteine allowing treatment of distal intestinal obstruction syndrome without the need for enterotomy. ( 29769187 )
2018
25
Intestinal obstruction caused by a strangulating adnexa: a rare complication of ovarian sparing hysterectomy. ( 29444792 )
2018
26
Intestinal obstruction caused by desmoid tumours: a review of the literature. ( 29760935 )
2018
27
Hydrocephalus recurrence and intestinal obstruction due to giant CSF pseudocyst. ( 29330586 )
2018
28
Amyloidosis of the colon and clinical features of intestinal obstruction. ( 29146072 )
2018
29
Acute Appendicitis Masquerading Distal Intestinal Obstruction Syndrome in Adult Cystic Fibrosis. ( 30356411 )
2018
30
Laparoscopic treatment of intestinal obstruction due to a vitelline vascular remnant and simultaneous appendicitis: a case report. ( 30167990 )
2018
31
A case report of primary central nervous system lymphoma with intestinal obstruction as the initial symptom. ( 29517670 )
2018
32
Incomplete intestinal obstruction as an initial and persistent presentation in chronic inflammatory demyelinating polyneuropathy: A case report. ( 30544461 )
2018
33
Eosinophilic colitis as a cause of intestinal obstruction: A case study. ( 30337117 )
2018
34
Comparing the management of constipation and distal intestinal obstruction syndrome between paediatricians and adult physicians. ( 29029973 )
2018
35
Interventions for treating distal intestinal obstruction syndrome (DIOS) in cystic fibrosis. ( 30075058 )
2018
36
Iron-deficiency anemia with lithobezoar (pica): a rare cause of intestinal obstruction in a 5-year-old Nigerian child. ( 30271221 )
2018
37
Intestinal obstruction secondary to cecal endometriosis. ( 30074015 )
2018
38
Intestinal obstruction caused by endometriosis: Endoscopic stenting and expedited laparoscopic resection avoiding stoma. A case report and review of the literature. ( 29477925 )
2018
39
Synchronous Neuroendocrine Carcinoma of Colon Presenting as Subacute Intestinal Obstruction-a Rare Case Report. ( 28447224 )
2018
40
A rare cause of recurrent intestinal obstruction. ( 28993072 )
2018
41
Heterotopic Pancreas. Intestinal Obstruction Caused by a Yeyunal Intussuception. ( 29103610 )
2018
42
Hemorrhage and intestinal obstruction secondary to a Meckel's diverticulum: a case report. ( 29168644 )
2018
43
Intestinal Obstruction of Uncommon Cause and Point-of-Care Ultrasonography - Where Do We Stand? ( 29457049 )
2018
44
Small intestine strictures in opium addicts: An unrecognized cause of intestinal obstruction. ( 29512022 )
2018
45
A case of intestinal obstruction due to inflammatory changes in the small intestine from alkaline ingestion. ( 29988685 )
2018
46
Mechanical intestinal obstruction caused by displacement of a stomach balloon - case report. ( 30002764 )
2018
47
Incomplete Distal Intestinal Obstruction Syndrome Complicated by Oligosymptomatic Intussusception. ( 30038925 )
2018
48
Intestinal obstruction as a cause of death in the mentally disabled. ( 30076536 )
2018
49
Qat-induced intestinal obstruction: A case series of a new entity. ( 30090746 )
2018
50
Intestinal obstruction caused by low-grade appendiceal mucinous neoplasm: A case report and review of the literature. ( 30138868 )
2018
Sources

Variations for Intestinal Obstruction

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Expression for Intestinal Obstruction

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Search GEO for disease gene expression data for Intestinal Obstruction.
Sources

Pathways for Intestinal Obstruction

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Sources

GO Terms for Intestinal Obstruction

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Biological processes related to Intestinal Obstruction according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.85 EDNRB FLNA GDNF RET TWIST1
2 positive regulation of cell proliferation GO:0008284 9.83 CDX2 EDN3 EDNRB GDNF NOD2
3 nervous system development GO:0007399 9.8 ACHE EDNRB GDNF NRTN RET
4 mRNA stabilization GO:0048255 9.54 GDNF MTOR
5 response to pain GO:0048265 9.52 EDNRB RET
6 melanocyte differentiation GO:0030318 9.51 EDN3 EDNRB
7 positive regulation of cell differentiation GO:0045597 9.5 CDX2 EDN3 GDNF
8 vasoconstriction GO:0042310 9.49 EDN3 EDNRB
9 positive regulation of potassium ion transmembrane transport GO:1901381 9.48 EDN3 FLNA
10 positive regulation of neuron maturation GO:0014042 9.37 MTOR RET
11 vein smooth muscle contraction GO:0014826 9.26 EDN3 EDNRB
12 posterior midgut development GO:0007497 9.16 EDNRB RET
13 enteric nervous system development GO:0048484 9.13 EDNRB GDNF RET
14 neural crest cell migration GO:0001755 9.02 EDN3 EDNRB GDNF NRTN RET

Molecular functions related to Intestinal Obstruction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.13 GDNF NRTN RET
2 protein-containing complex binding GO:0044877 8.92 CFTR FLNA MTOR NOD2
Sources

Sources for Intestinal Obstruction

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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