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MCID: INT071
MIFTS: 45

Intestinal Perforation

Categories: Gastrointestinal diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Intestinal Perforation

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MalaCards integrated aliases for Intestinal Perforation:

Name: Intestinal Perforation 12 45 15 17 74
Perforation of Intestine 12

Classifications:

MalaCards categories:
Anatomical: Gastrointestinal diseases
See all MalaCards categories (disease lists)
ICD10: 34


External Ids:

Disease Ontology 12 DOID:2074
ICD9CM 36 569.83
MeSH 45 D007416
NCIt 51 C39611
SNOMED-CT 69 56905009
ICD10 34 K63.1
UMLS 74 C0021845
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Summaries for Intestinal Perforation

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MalaCards based summary : Intestinal Perforation, also known as perforation of intestine, is related to pleomorphic carcinoma and adenosquamous carcinoma. An important gene associated with Intestinal Perforation is PTS (6-Pyruvoyltetrahydropterin Synthase), and among its related pathways/superpathways are Shigellosis and Doxorubicin Pathway, Pharmacokinetics. The drugs Omeprazole and Diclofenac have been mentioned in the context of this disorder. Affiliated tissues include colon, small intestine and liver, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

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Related Diseases for Intestinal Perforation

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Diseases related to Intestinal Perforation via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 186)
# Related Disease Score Top Affiliating Genes
1 pleomorphic carcinoma 30.1 KRT7 NKX2-1
2 adenosquamous carcinoma 29.7 KRT7 NKX2-1
3 intestinal obstruction 29.7 KRT7 NOD2
4 spondyloarthropathy 1 29.3 CRP NOD2
5 perinatal intestinal perforation 12.5
6 hirschsprung disease 1 11.1
7 enterocolitis 10.5
8 perinatal necrotizing enterocolitis 10.5
9 typhoid fever 10.5
10 peritonitis 10.4
11 dyskinetic cerebral palsy 10.3 NKX2-1 PTS
12 tetrahydrobiopterin deficiency 10.2 NOS1 PTS
13 solid adenocarcinoma with mucin production 10.2 KRT7 NKX2-1
14 ovarian germ cell teratoma 10.2 KRT7 NKX2-1
15 lung acinar adenocarcinoma 10.2 KRT7 NKX2-1
16 small cell carcinoma of the bladder 10.2 KRT7 NKX2-1
17 small cell carcinoma 10.2 KRT7 NKX2-1
18 ovarian germ cell cancer 10.2 KRT7 NKX2-1
19 papillary adenoma 10.2 KRT7 NKX2-1
20 papillary serous adenocarcinoma 10.2 KRT7 NKX2-1
21 pulmonary sclerosing hemangioma 10.2 KRT7 NKX2-1
22 sclerosing hemangioma 10.2 KRT7 NKX2-1
23 mucinous bronchioloalveolar adenocarcinoma 10.2 KRT7 NKX2-1
24 alveoli adenoma 10.2 KRT7 NKX2-1
25 atypical choroid plexus papilloma 10.2 KRT7 NKX2-1
26 cystic teratoma 10.2 KRT7 NKX2-1
27 ovarian cystic teratoma 10.2 KRT7 NKX2-1
28 horseshoe kidney 10.2 KRT7 NKX2-1
29 hidradenocarcinoma 10.2 KRT7 NKX2-1
30 large cell neuroendocrine carcinoma 10.2 KRT7 NKX2-1
31 mucinous adenocarcinoma 10.2 KRT7 NKX2-1
32 papillary adenocarcinoma 10.2 KRT7 NKX2-1
33 bronchiolo-alveolar adenocarcinoma 10.1 KRT7 NKX2-1
34 lymphoma 10.1
35 lung benign neoplasm 10.1 KRT7 NKX2-1
36 cavernous hemangioma 10.1 KRT7 NKX2-1
37 purpura 10.1
38 large cell carcinoma 10.1 KRT7 NKX2-1
39 crohn's disease 10.1
40 polyarteritis nodosa 10.0
41 miliary tuberculosis 10.0
42 cytomegalovirus infection 10.0
43 streptococcal meningitis 10.0 CRP NOD2
44 mesenteric lymphadenitis 10.0 CRP NOD2
45 merkel cell carcinoma 10.0 KRT7 NKX2-1
46 hyperphenylalaninemia 10.0 NOS1 PTS
47 malignant atrophic papulosis 10.0
48 inguinal hernia 10.0
49 henoch-schoenlein purpura 10.0
50 ehlers-danlos syndrome 10.0

Comorbidity relations with Intestinal Perforation via Phenotypic Disease Network (PDN): (show all 15)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Acute Vascular Insufficiency of Intestine
Cecal Benign Neoplasm Colorectal Cancer
Deficiency Anemia Familial Atrial Fibrillation
Heart Disease Intestinal Obstruction
Paralytic Ileus Peritonitis
Protein-Energy Malnutrition Rectosigmoid Junction Neoplasm
Respiratory Failure

Graphical network of the top 20 diseases related to Intestinal Perforation:



Diseases related to Intestinal Perforation
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Symptoms & Phenotypes for Intestinal Perforation

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GenomeRNAi Phenotypes related to Intestinal Perforation according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-111 9.36 NOD2
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-148 9.36 CRP
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.36 CRP
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.36 CRP KRT7 NOD2
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.36 KRT7
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-72 9.36 KRT7
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-77 9.36 NOD2
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-89 9.36 CRP
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.36 KRT7

MGI Mouse Phenotypes related to Intestinal Perforation:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.73 COL3A1 CRP NKX2-1 NOS1 PRDM6 PTS
2 digestive/alimentary MP:0005381 9.63 COL3A1 NFKB1 NKX2-1 NOD2 NOS1 PTS
3 homeostasis/metabolism MP:0005376 9.61 COL3A1 CRP KRT7 NFKB1 NKX2-1 NOD2
4 respiratory system MP:0005388 9.02 COL3A1 NFKB1 NKX2-1 NOS1 PRDM6
Sources

Drugs & Therapeutics for Intestinal Perforation

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Drugs for Intestinal Perforation (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 176)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Omeprazole Approved, Investigational, Vet_approved Phase 4 73590-58-6 4594
2
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
3
Celecoxib Approved, Investigational Phase 4 169590-42-5 2662
4
Naproxen Approved, Vet_approved Phase 4 22204-53-1 156391 1302
5
Ibuprofen Approved Phase 4,Phase 2,Not Applicable 15687-27-1 3672
6 Peripheral Nervous System Agents Phase 4,Phase 2,Not Applicable
7 Antirheumatic Agents Phase 4,Phase 2,Not Applicable
8 Analgesics Phase 4,Phase 2,Not Applicable
9 Cyclooxygenase 2 Inhibitors Phase 4
10 Anti-Ulcer Agents Phase 4
11 Antacids Phase 4
12 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3,Not Applicable
13 Proton Pump Inhibitors Phase 4
14 Cyclooxygenase Inhibitors Phase 4,Phase 2,Not Applicable
15 Gastrointestinal Agents Phase 4,Not Applicable
16 Analgesics, Non-Narcotic Phase 4,Phase 2,Not Applicable
17 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 2,Not Applicable
18
Simethicone Approved Phase 3 8050-81-5
19
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
20
Fluconazole Approved, Investigational Phase 3 86386-73-4 3365
21
Ampicillin Approved, Vet_approved Phase 2, Phase 3 69-53-4 6249
22
Piperacillin Approved Phase 2, Phase 3 66258-76-2 43672
23
Metronidazole Approved Phase 2, Phase 3 443-48-1 4173
24
Tazobactam Approved Phase 2, Phase 3 89786-04-9 123630
25
Clindamycin Approved, Vet_approved Phase 2, Phase 3 18323-44-9 29029
26
leucovorin Approved Phase 3,Phase 2 58-05-9 143 6006
27
Betamethasone Approved, Vet_approved Phase 2, Phase 3,Phase 3 378-44-9 9782
28
Pravastatin Approved Phase 3 81093-37-0 54687
29
Amoxicillin Approved, Vet_approved Phase 3 26787-78-0 33613
30
Meropenem Approved, Investigational Phase 3 119478-56-7, 96036-03-2 441130 64778
31
Doripenem Approved, Investigational Phase 3 148016-81-3 73303
32
Vitamin D3 Approved, Nutraceutical Phase 2, Phase 3,Phase 3 67-97-0 5280795 6221
33
Ergocalciferol Approved, Nutraceutical Phase 2, Phase 3 50-14-6 5280793
34
Calcium Approved, Nutraceutical Phase 2, Phase 3 7440-70-2 271
35
Vitamin D Approved, Nutraceutical, Vet_approved Phase 2, Phase 3 1406-16-2
36
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3,Phase 2 59-30-3 6037
37 Omega 3 Fatty Acid Phase 3
38 Cola Phase 2, Phase 3,Phase 1,Not Applicable
39 Calciferol Phase 2, Phase 3
40 Vitamins Phase 2, Phase 3,Phase 3
41 Ergocalciferols Phase 2, Phase 3
42 Bone Density Conservation Agents Phase 2, Phase 3
43 Calcium, Dietary Phase 2, Phase 3
44 Hormones Phase 2, Phase 3,Phase 3
45 Nutrients Phase 2, Phase 3,Phase 3
46 Trace Elements Phase 2, Phase 3,Phase 3
47 Micronutrients Phase 2, Phase 3,Phase 3
48 Vitamin D2 Phase 2, Phase 3
49 Anti-Infective Agents Phase 3,Phase 2,Phase 1,Not Applicable
50 Hormone Antagonists Phase 3,Phase 2

Interventional clinical trials:

(show top 50) (show all 115)
# Name Status NCT ID Phase Drugs
1 Study of Tomography of Nephrolithiasis Evaluation Completed NCT01451931 Phase 4
2 Study Of Celecoxib Or Diclofenac And Omeprazole For Gastrointestinal (GI) Safety In High GI Risk Patients With Arthritis Completed NCT00141102 Phase 4 Celecoxib;Diclofenac + Omeprazole
3 Effect of Early Nutritional Therapy on Frailty, Functional Outcomes and Recovery of Undernourished Medical Inpatients Trial Completed NCT02517476 Phase 4
4 GI-Reasons- A Trial Of GI Safety Of Celecoxib Compared With Non-Selective Nonsteroidal Antiinflammatory Drugs (NSAIDS) Completed NCT00373685 Phase 4 Celecoxib;Any commercially available NSAID with the indication for osteoarthritis
5 Prospective Randomized Evaluation Of Celecoxib Integrated Safety Vs Ibuprofen Or Naproxen Completed NCT00346216 Phase 4 celecoxib;Ibuprofen;Naproxen
6 Evaluation of Use of Plastic Bags to Prevent Neonatal Hypothermia-Part IV Completed NCT01604447 Phase 4
7 Evaluate the Use of Plastic Bags in Preventing and Treating Hypothermia in Neonates Completed NCT01403623 Phase 4
8 TRAP Intervention STudy: Early Versus Late Intervention for Twin Reversed Arterial Perfusion Sequence Recruiting NCT02621645 Phase 4
9 Comparison of Infant Pain Responses Between Two Different Methods of Urine Collection Unknown status NCT00298584 Phase 3
10 A Randomized Trial of Docosahexaenoic Acid Supplementation During Pregnancy to Prevent Deep Placentation Disorders Unknown status NCT02336243 Phase 3
11 Vitamin D Supplementation for Extremely Preterm Infants Completed NCT01600430 Phase 2, Phase 3
12 Fluconazole Prophylaxis for the Prevention of Candidiasis in Infants Less Than 750 Grams Birthweight Completed NCT00734539 Phase 3 fluconazole;placebo
13 Hartmann's Versus Primary Anastomosis in Left-sided Colon Perforation Completed NCT01233713 Phase 2, Phase 3
14 Antibiotic Safety (SCAMP) Completed NCT01994993 Phase 2, Phase 3 ampicillin and metronidazole and gentamicin;ampicillin and gentamicin and clindamycin;gentamicin and Piperacillin- tazobactam;standard of care antibiotics and metronidazole;metronidazole, clindamycin, or piperacillin-tazobactam
15 High Dose Folic Acid Supplementation Throughout Pregnancy for Preeclampsia Prevention Completed NCT01355159 Phase 3 Folic Acid 4 mg;Placebo
16 Eculizumab in Shiga-toxin Related Hemolytic and Uremic Syndrome Pediatric Patients - ECULISHU Completed NCT02205541 Phase 3 Eculizumab;Placebo
17 Does a Rescue Course of Betamethasone in Pregnant Women With PPROM Decrease Neonatal Morbidity? Recruiting NCT02939742 Phase 2, Phase 3 Betamethasone;Placebo
18 Antenatal Late Preterm Steroids (ALPS): A Randomized Placebo-Controlled Trial Active, not recruiting NCT01222247 Phase 3 Betamethasone;Placebo
19 A Randomized Trial to Prevent Congenital Cytomegalovirus (CMV) Active, not recruiting NCT01376778 Phase 3 CMV hyperimmune globulin
20 Cycled Phototherapy Not yet recruiting NCT03927833 Phase 3
21 Human Milk Fortification in Extremely Preterm Infants Not yet recruiting NCT03797157 Phase 2, Phase 3
22 Pravastatin to Prevent Preeclampsia Not yet recruiting NCT03944512 Phase 3 Pravastatin
23 Effects of Recto-colic Enemas of Butyrate on the Digestive Disorders of Very Low Birth Weight Preterms <1250 Grams Terminated NCT01536483 Phase 2, Phase 3 Butyrate enemas
24 A Safety and Tolerability Study of Doripenem Compared With Meropenem in Children Hospitalized With Complicated Intra-abdominal Infections Terminated NCT01110382 Phase 3 Doripenem;Meropenem placebo;Meropenem;Doripenem placebo;Amoxicillin/clavulanate potassium
25 Transvaginal Ultrasound Cervical Length Screening in Singleton Pregnancy Without Prior Spontaneous Preterm Birth Withdrawn NCT02928302 Phase 3
26 Early Treatment Versus Delayed Conservative Treatment of the Patent Ductus Arteriosus Completed NCT01958320 Phase 2 NSAID
27 Early Supplementation of Enteral Microlipid With and Without Fish Oil in Premature Infants With Enterostomies Completed NCT01674478 Phase 2
28 IPHC in Patients With Platinum-sensitive Recurrent Ovarian Cancer Completed NCT01588964 Phase 2
29 Paclitaxel and Carboplatin With Or Without Sorafenib In The First-Line Treatment Of Patients With Ovarian Cancer Completed NCT00390611 Phase 2 Sorafenib;Paclitaxel;Carboplatin
30 Vargatef in Addition to First Line Chemotherapy With Interval Debulking Surgery in Patients With Ovarian Cancer Completed NCT01583322 Phase 2 vargatef;placebo
31 Phase II Trial of FOLFOX6, Bevacizumab and Cetuximab in Patients With Colorectal Cancer Completed NCT00100841 Phase 2 oxaliplatin;leucovorin calcium;fluorouracil
32 Bevacizumab or Cetuximab And Gemcitabine Hydrochloride, Capecitabine, and Radiation Therapy in Treating Patients With Pacreatic Cancer That Has Been Completely Removed By Surgery Completed NCT00305877 Phase 2 gemcitabine hydrochloride;capecitabine
33 Vinorelbine and Bevacizumab in Treating Older Patients With Stage III or Stage IV Non-Small Cell Lung Cancer Completed NCT00309998 Phase 2 vinorelbine tartrate
34 Trial of Vascular Endothelial Growth Factor (VEGF), Bevacizumab, in Combination With Cytotoxic Chemotherapy for Endometrial Cancer Completed NCT00879359 Phase 2 carboplatin, paclitaxel, and bevacizumab
35 Effects of Extensive Abdominal Lavage on Postoperative Inflammation Following Full Thickness Excision of Deep Endometriosis Completed NCT00930696 Phase 2
36 CABI: Antibiotic Duration for Complicated Intra-ABdominal Infection Recruiting NCT03265834 Phase 2
37 Prospective Evaluation of the Ablation Therapy With Bipolar Radio Frequency for Nonresectable Bile Duct Cancer Recruiting NCT03679338 Phase 2
38 Randomized Controlled Trial to Evaluate the Safety and Efficacy of Acetaminophen in Preterm Infants Used in Combination With Ibuprofen for Closure of the Ductus Arteriosus Recruiting NCT03701074 Phase 2 Ibuprofen and acetaminophen;Ibuprofen and placebo
39 Paracetamol in Patent Ductus Arteriosus Recruiting NCT02422966 Phase 2 Paracetamol;Ibuprofen
40 Bevacizumab With or Without Trebananib in Treating Patients With Recurrent Brain Tumors Active, not recruiting NCT01609790 Phase 2
41 Transanal Decompression Tube Versus Stent for Acute Malignant Left-sided Colonic and Rectal Obstruction Terminated NCT02585271 Phase 2
42 Bevacizumab, Erlotinib and Capecitabine for Advanced Pancreatic Cancer Completed NCT00614653 Phase 1 Bevacizumab;Erlotinib;Capecitabine
43 Therapeutic Oxygen for Gastrointestinal Atony (TOGA) Recruiting NCT03386136 Phase 1 100% Oxygen
44 A Dose Escalation Trial of SBRT After Induction Chemotherapy for Locally Advanced Pancreatic Cancer Recruiting NCT02873598 Phase 1 FOLFIRINOX or gemcitabine/abraxane
45 A Dose Escalation Trial of Stereotactic Body Radiotherapy (SBRT) After Induction Chemotherapy for Locally Advanced Pancreatic Cancer Active, not recruiting NCT02643498 Phase 1
46 IRT in Infants With Intestinal Perforation Unknown status NCT01530828
47 Colonic Motility in Constipation and Ageing Unknown status NCT02575742
48 Safety and Efficacy Study of Cylindrical Abdominoperineal Resection to Treat Rectal Cancer Unknown status NCT00949273
49 A Study to Evaluate the Efficacy of Seattle-PAP for the Respiratory Support of Premature Infants Unknown status NCT03085329 Not Applicable
50 Observational Study of Surgical Treatment of Necrotizing Enterocolotis Completed NCT01223261

Search NIH Clinical Center for Intestinal Perforation

Cochrane evidence based reviews: intestinal perforation

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Genetic Tests for Intestinal Perforation

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Anatomical Context for Intestinal Perforation

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MalaCards organs/tissues related to Intestinal Perforation:

42
Colon, Small Intestine, Liver, Bone, Brain, Pancreas, Heart
Sources

Publications for Intestinal Perforation

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Articles related to Intestinal Perforation:

(show top 50) (show all 558)
# Title Authors Year
1
Intestinal failure associated cholestasis in surgical necrotizing enterocolitis and spontaneous intestinal perforation. ( 30413273 )
2019
2
Fragility of Life: Recurrent Intestinal Perforation Due to Vascular Ehlers-Danlos Syndrome. ( 30656563 )
2019
3
Caffeine exposure and acute kidney injury in premature infants with necrotizing enterocolitis and spontaneous intestinal perforation. ( 30415418 )
2019
4
Small intestinal perforation due to a huge gastrointestinal stromal tumor in a kidney transplant recipient: a case report and literature review. ( 30943904 )
2019
5
Meconial hydrocele as first sign of acute intestinal perforation in a preterm baby. ( 30269084 )
2019
6
Necrotizing Enterocolitis and Spontaneous Intestinal Perforation: A Spatiotemporal Case Cluster Analysis. ( 30937409 )
2019
7
Intestinal Perforation Secondary to Pits of Jujube Ingestion: A Single-Center Experience with 18 Cases. ( 30659341 )
2019
8
Intestinal perforation after liposuction. ( 30683272 )
2019
9
Impact of practice change on intestinal perforation risk for pediatric gastrojejunostomy tube placement. ( 30819544 )
2019
10
Malakoplakia of the colon following renal transplantation in a 73 year old woman: report of a case presenting as intestinal perforation. ( 30866984 )
2019
11
Salmonella enterica serovar enteritidis peritonitis with spontaneous intestinal perforation in an immunocompetent patient. ( 30898965 )
2019
12
The Association between Absence of Abdominal Pain and Mortality in Lower Intestinal Perforation in Patients with Autoimmune Rheumatic Diseases. ( 30906775 )
2019
13
Use of contrast-enhanced post-mortem computed tomography to diagnose intestinal perforation caused by malpractice: A case report. ( 30946346 )
2019
14
Intestinal Perforation in ACTH-Dependent Cushing's Syndrome. ( 31001560 )
2019
15
When traditions become dangerous: Intestinal perforation from unusual foreign body-Case report and short literature review. ( 31024984 )
2019
16
Ongoing Computed Tomography Appraisal of Intestinal Perforation Due to an Ingested Foreign Body. ( 31043580 )
2019
17
Long-term outcomes of very low birth weight infants with spontaneous intestinal perforation: A retrospective case-matched cohort study. ( 31084913 )
2019
18
Malignant atrophic papulosis with motor aphasia and intestinal perforation: A case report and review of published works. ( 29516548 )
2018
19
Surgical treatment of intestinal perforation in Behçet Syndrome: an unusual presentation. ( 30574248 )
2018
20
Predictive Value of the Aspartate Aminotransferase to Platelet Ratio Index for Parenteral Nutrition-Associated Cholestasis in Premature Infants With Intestinal Perforation. ( 28792861 )
2018
21
Intestinal Perforation due to Deep Infiltrating Endometriosis during Pregnancy: Case Report. ( 29747214 )
2018
22
Outcomes of surgery for necrotizing enterocolitis and spontaneous intestinal perforation in Finland during 1986-2014. ( 30122449 )
2018
23
Estimation of Neonatal Intestinal Perforation Associated with Necrotizing Enterocolitis by Machine Learning Reveals New Key Factors. ( 30423965 )
2018
24
Preterm infants undergoing laparotomy for necrotizing enterocolitis or spontaneous intestinal perforation display evidence of impaired cerebrovascular autoregulation. ( 29454185 )
2018
25
Diagnosis and treatment of postoperative intestinal perforation in infants and young children with congenital heart disease: A report of three cases. ( 29731834 )
2018
26
Intestinal Perforation Due to Crohn's Ileitis Immunosuppression Related Lymphoma and Meckel's Diverticulum. ( 29730434 )
2018
27
Adhesive intestinal obstruction increases the risk of intestinal perforation in peritoneal dialysis patients: a case report. ( 29954334 )
2018
28
Risk factors for spontaneous localized intestinal perforation in the preterm infant. ( 28671044 )
2018
29
A Single-Center Experience with Very Low Birth Weight Infants and Focal Intestinal Perforation: Comparison of Primary Anastomosis versus Stoma Opening. ( 28837996 )
2018
30
Polymicrobial Anaerobic Bacteremia Caused by Butyricimonas virosa and Brachyspira pilosicoli in a Patient with Peritonitis following Intestinal Perforation. ( 29071824 )
2018
31
Intestinal Perforation Associated With Perinatal Asphyxia and Anaemia. ( 29077644 )
2018
32
Management of neonatal spontaneous intestinal perforation by peritoneal needle aspiration. ( 29120457 )
2018
33
Determinants of postoperative morbidity and mortality in children managed for typhoid intestinal perforation in Kano Nigeria. ( 29277466 )
2018
34
Clinical predictors of bevacizumab-associated intestinal perforation in non-small cell lung cancer. ( 29536229 )
2018
35
Comment on: Delayed intestinal perforation and vertebral osteomyelitis after high-intensity focused ultrasound treatment for uterine leiomyoma. ( 29569640 )
2018
36
Bevacizumab-induced intestinal perforation in a patient with inoperable breast cancer: a case report and review of the literature. ( 29580267 )
2018
37
Intestinal perforation by a peritoneal dialysis catheter in which fungal peritonitis led to diagnosis: a rare case report. ( 29611117 )
2018
38
Intestinal perforation secondary to strangulated internal hernia after Roux-en-Y gastric bypass. ( 29625883 )
2018
39
Delayed intestinal perforation secondary to blunt force abdominal trauma in a cat. ( 29662682 )
2018
40
Sonographic and CT imaging features of intestinal perforation from a pill and packing: A case report. ( 29668604 )
2018
41
Intestinal perforation after surgical treatment for incisional hernia: iatrogenic or idiopathic? ( 29707608 )
2018
42
Intestinal perforation after regorafenib usage. ( 29749339 )
2018
43
Intestinal perforation due to typhoid fever in Karamoja (Uganda). ( 29848809 )
2018
44
Recurrent Spontaneous Intestinal Perforation due to STAT1 GOF Mutation. ( 29880965 )
2018
45
Peritonitis with small intestinal perforation caused by a plastic bread bag clip: A case report. ( 30153609 )
2018
46
Early postoperative outcomes of surgery for intestinal perforation in NEC based on intestinal location of disease. ( 30278493 )
2018
47
Tuberculous peritonitis following intestinal perforation in malignancy. ( 30304137 )
2018
48
A 14-year-old girl presenting with tuberculous intestinal perforation while in a temporary shelter after the 2015 earthquake in Nepal. ( 28121264 )
2018
49
Intestinal Perforation by a Toothpick as Reason for Necrotizing Fasciitis. ( 30416948 )
2018
50
Intestinal perforation secondary to intestinal diffuse large b-cell lymphoma in a patient with coeliac disease. ( 29054322 )
2018
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Variations for Intestinal Perforation

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Expression for Intestinal Perforation

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Search GEO for disease gene expression data for Intestinal Perforation.
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Pathways for Intestinal Perforation

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Pathways related to Intestinal Perforation according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Shigellosis 38
11.07 NFKB1 NOD2
2
Doxorubicin Pathway, Pharmacokinetics 62
Show member pathways
 10.76 NFKB1 NOS1
3
Apoptosis and survival_Anti-apoptotic action of nuclear ESR1 and ESR2 23
10.4 NFKB1 NOS1
4
Canonical NF-kappaB pathway 1
9.98 NFKB1 NOD2
Sources

GO Terms for Intestinal Perforation

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Cellular components related to Intestinal Perforation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 specific granule lumen GO:0035580 8.62 DEFA4 NFKB1

Biological processes related to Intestinal Perforation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to hormone GO:0009725 9.16 NKX2-1 NOS1
2 interleukin-1-mediated signaling pathway GO:0070498 8.96 NFKB1 NOD2
3 cellular response to lipopolysaccharide GO:0071222 8.8 DEFA4 NFKB1 NOD2

Molecular functions related to Intestinal Perforation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein homodimerization activity GO:0042803 9.26 DEFA4 NFKB1 PRDM6 PTS
2 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977 8.8 NFKB1 NKX2-1 PRDM6
Sources

Sources for Intestinal Perforation

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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