MCID: INT071
MIFTS: 49

Intestinal Perforation

Categories: Gastrointestinal diseases
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Aliases & Classifications for Intestinal Perforation

MalaCards integrated aliases for Intestinal Perforation:

Name: Intestinal Perforation 11 43 14 16 71
Perforation of Intestine 11 31

Classifications:



External Ids:

Disease Ontology 11 DOID:2074
ICD9CM 34 569.83
MeSH 43 D007416
NCIt 49 C39611
SNOMED-CT 68 56905009
ICD10 31 K63.1
UMLS 71 C0021845

Summaries for Intestinal Perforation

MalaCards based summary: Intestinal Perforation, also known as perforation of intestine, is related to peritonitis and patent ductus arteriosus 1. An important gene associated with Intestinal Perforation is NOD2 (Nucleotide Binding Oligomerization Domain Containing 2), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Amoxicillin and Doripenem have been mentioned in the context of this disorder. Affiliated tissues include liver, colon and small intestine, and related phenotypes are Increased shRNA abundance (Z-score > 2) and homeostasis/metabolism

Related Diseases for Intestinal Perforation

Diseases related to Intestinal Perforation via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1197)
# Related Disease Score Top Affiliating Genes
1 peritonitis 30.9 TNF NOD2 IL6 IL10 CRP ALB
2 patent ductus arteriosus 1 30.8 VEGFA IL6 CRP ALB
3 enterocolitis 30.8 TNF NOD2 IL6 IL10 FABP2 CRP
4 typhoid fever 30.8 TNF IL6 GPT CRP CCR6 ALB
5 ileus 30.7 TNF IL6 IL10 CRP
6 vasculitis 30.6 TNF IL6 IL10 CRP
7 inguinal hernia 30.6 IL6 GPT CRP ALB
8 polyarteritis nodosa 30.6 TNF IL6 GPT CRP
9 intussusception 30.5 VEGFA IL6 CRP ALB
10 toxic shock syndrome 30.5 TNF IL6 IL10 CRP
11 ascaris lumbricoides infection 30.5 IL10 GPT CD4 ALB
12 purpura 30.4 TNF IL6 IL10 CRP
13 intestinal tuberculosis 30.4 TNF NOD2 CRP CD4 ALB
14 behcet syndrome 30.4 VEGFA TNF NOD2 IL6 IL10 CRP
15 megacolon 30.4 CCR6 ATP4A ATP12A
16 meckel diverticulum 30.3 CRP ATP4A ATP12A ALB
17 inflammatory bowel disease 1 30.2 TNF NOD2 IL6 IL10 CCR6
18 adult respiratory distress syndrome 30.2 TNF IL6 IL10 CRP CCR6
19 necrotizing fasciitis 30.1 TNF IL6 CRP ALB
20 amyloidosis 30.1 TNF IL6 CRP ALB
21 duodenal ulcer 30.1 TNF IL6 IL10
22 diverticulitis 30.1 TNF IL6 CRP CCR6 ATP4A ATP12A
23 asphyxia neonatorum 30.1 IL6 CRP ALB
24 brucellosis 30.1 TNF IL6 IL10 CRP
25 henoch-schoenlein purpura 30.1 TNF IL6 CRP CD4 CCR6 ALB
26 perinatal necrotizing enterocolitis 30.1 TNF NOD2 IL6 IL10 FABP2 CRP
27 cholecystitis 30.0 GPT CRP ALB
28 periventricular leukomalacia 30.0 TNF IL6 CRP
29 compartment syndrome 30.0 TNF IL6 GPT CRP ALB
30 gastroenteritis 30.0 TNF IL6 IL10 CRP ALB
31 disseminated intravascular coagulation 30.0 TNF IL6 IL10 GPT CRP
32 angiodysplasia 30.0 VEGFA ATP4A ATP12A
33 gastric ulcer 30.0 VEGFA IL6 ATP12A
34 mitral valve insufficiency 30.0 GPT CRP ALB
35 appendicitis 30.0 TNF IL6 IL10 FABP2 CRP ALB
36 anal fistula 29.9 TNF KRT7 CRP ALB
37 pulmonary tuberculosis 29.9 TNF IL6 IL10 CRP ALB
38 diaphragmatic hernia, congenital 29.9 VEGFA NKX2-1 CRP ATP4A ATP12A
39 portal hypertension 29.9 TNF GPT CCR6 ALB
40 acute kidney failure 29.9 IL6 GPT ALB
41 superior mesenteric artery syndrome 29.9 CRP ATP4A ATP12A ALB
42 gastric dilatation 29.9 CRP ATP4A ATP12A ALB
43 lymphoma, mucosa-associated lymphoid type 29.9 CD4 CCR6 ATP4A ATP12A
44 obstructive jaundice 29.9 KRT7 GPT CRP ALB
45 active peptic ulcer disease 29.9 GPT CRP ATP4A ATP12A ALB
46 infective endocarditis 29.9 IL6 CRP CCR6 ALB
47 chorioamnionitis 29.9 VEGFA TNF IL6 IL10 CRP
48 hemangioma 29.9 VEGFA NKX2-1 KRT7 IL6
49 granulomatous angiitis 29.9 CRP CD8A CD4
50 bronchiectasis 29.9 TNF IL6 CRP ALB

Comorbidity relations with Intestinal Perforation via Phenotypic Disease Network (PDN): (show all 15)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Acute Vascular Insufficiency of Intestine
Cecal Benign Neoplasm Colorectal Cancer
Deficiency Anemia Familial Atrial Fibrillation
Heart Disease Intestinal Obstruction
Paralytic Ileus Peritonitis
Protein-Energy Malnutrition Rectosigmoid Junction Neoplasm
Respiratory Failure

Graphical network of the top 20 diseases related to Intestinal Perforation:



Diseases related to Intestinal Perforation

Symptoms & Phenotypes for Intestinal Perforation

GenomeRNAi Phenotypes related to Intestinal Perforation according to GeneCards Suite gene sharing:

25 (show all 27)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 10.17 ALB ATP12A ATP4A CCR6 CD4 CD8A
2 no effect GR00402-S-2 10.17 ALB ATP12A ATP4A CCR6 CD4 CRP
3 Increased shRNA abundance (Z-score > 2) GR00366-A-100 10.1 IL10
4 Increased shRNA abundance (Z-score > 2) GR00366-A-113 10.1 IL10
5 Increased shRNA abundance (Z-score > 2) GR00366-A-120 10.1 CRP
6 Increased shRNA abundance (Z-score > 2) GR00366-A-125 10.1 IL10
7 Increased shRNA abundance (Z-score > 2) GR00366-A-135 10.1 KRT7
8 Increased shRNA abundance (Z-score > 2) GR00366-A-147 10.1 CRP
9 Increased shRNA abundance (Z-score > 2) GR00366-A-148 10.1 CRP
10 Increased shRNA abundance (Z-score > 2) GR00366-A-152 10.1 IL10
11 Increased shRNA abundance (Z-score > 2) GR00366-A-161 10.1 CRP IL10
12 Increased shRNA abundance (Z-score > 2) GR00366-A-192 10.1 KRT7
13 Increased shRNA abundance (Z-score > 2) GR00366-A-198 10.1 IL10
14 Increased shRNA abundance (Z-score > 2) GR00366-A-210 10.1 IL10 NOD2
15 Increased shRNA abundance (Z-score > 2) GR00366-A-214 10.1 IL10
16 Increased shRNA abundance (Z-score > 2) GR00366-A-36 10.1 NOD2
17 Increased shRNA abundance (Z-score > 2) GR00366-A-52 10.1 IL10
18 Increased shRNA abundance (Z-score > 2) GR00366-A-53 10.1 IL10
19 Increased shRNA abundance (Z-score > 2) GR00366-A-63 10.1 CRP
20 Increased shRNA abundance (Z-score > 2) GR00366-A-65 10.1 IL10
21 Increased shRNA abundance (Z-score > 2) GR00366-A-67 10.1 IL10
22 Increased shRNA abundance (Z-score > 2) GR00366-A-68 10.1 IL10 KRT7
23 Increased shRNA abundance (Z-score > 2) GR00366-A-72 10.1 KRT7
24 Increased shRNA abundance (Z-score > 2) GR00366-A-74 10.1 KRT7
25 Increased shRNA abundance (Z-score > 2) GR00366-A-82 10.1 IL10
26 Increased shRNA abundance (Z-score > 2) GR00366-A-85 10.1 IL10
27 Increased shRNA abundance (Z-score > 2) GR00366-A-91 10.1 KRT7

MGI Mouse Phenotypes related to Intestinal Perforation:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.32 ALB ATP12A ATP4A CCR6 CD4 CRP
2 endocrine/exocrine gland MP:0005379 10.13 ALB ATP4A CD4 CD8A IL10 IL6
3 digestive/alimentary MP:0005381 10.07 ALB ATP12A ATP4A CD4 IL10 IL6
4 muscle MP:0005369 10.03 ALB IL10 IL6 NFKB1 NOS1 PTS
5 liver/biliary system MP:0005370 10.01 ALB FABP2 IL10 IL6 NFKB1 NOS1
6 neoplasm MP:0002006 10 ALB ATP4A IL10 IL6 NKX2-1 TNF
7 cellular MP:0005384 9.93 ALB CD4 CD8A IL10 IL6 KRT7
8 immune system MP:0005387 9.83 ALB ATP4A CCR6 CD4 CD8A CRP
9 mortality/aging MP:0010768 9.47 ALB ATP4A CD4 CD8A IL10 IL6

Drugs & Therapeutics for Intestinal Perforation

Drugs for Intestinal Perforation (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amoxicillin Approved, Vet_approved Phase 3 26787-78-0 33613
2
Doripenem Approved, Investigational Phase 3 148016-81-3 73303
3
Meropenem Approved, Investigational Phase 3 119478-56-7, 96036-03-2 441130
4
Clavulanic acid Approved, Vet_approved Phase 3 58001-44-8 5280980
5 Pharmaceutical Solutions Phase 3
6 Amoxicillin-Potassium Clavulanate Combination Phase 3
7 Anti-Bacterial Agents Phase 3
8 beta-Lactamase Inhibitors Phase 3
9 Anti-Infective Agents Phase 3
10
Indomethacin Approved, Investigational Phase 2 53-86-1 3715
11
Acetaminophen Approved Phase 2 103-90-2 1983
12
Ibuprofen Approved Phase 2 15687-27-1 3672
13
Bupivacaine Approved, Investigational 2180-92-9, 38396-39-3 2474
14
Lidocaine Approved, Vet_approved 137-58-6 3676
15 Anesthetics, Local
16 Liver Extracts
17 Tea
18 Vaccines
19 Cola
20 Antibiotics, Antitubercular
21 Anesthetics
22 Analgesics
23 Analgesics, Opioid

Interventional clinical trials:

(show all 30)
# Name Status NCT ID Phase Drugs
1 A Prospective, Randomized, Double-Blind, Multicenter Study to Establish the Safety and Tolerability of Doripenem Compared With Meropenem in Hospitalized Children With Complicated Intra-Abdominal Infections Terminated NCT01110382 Phase 3 Doripenem;Meropenem placebo;Meropenem;Doripenem placebo;Amoxicillin/clavulanate potassium
2 Early Treatment Versus Delayed Conservative Treatment of the Patent Ductus Arteriosus in Preterm infants-a Multicenter Trial Completed NCT01958320 Phase 2 NSAID
3 Early Supplementation of Enteral Microlipid With and Without Fish Oil in Premature Infants With Enterostomies Completed NCT01674478 Phase 2
4 Immunoreactive Trypsinogen in Infants With Intestinal Perforation Unknown status NCT01530828
5 Proximal Remnant Intestinal Colonization in Newborn Infants With Enterostomy: a Longitudinal Study Unknown status NCT03340259
6 The BCAE Study: Best Care for Abdominal Emergencies Unknown status NCT04577339
7 Ultrasound Guided Transversus Abdominis Plane(TAP) Block in Intensive Care Unit(ICU) for Postoperative Analgesia After Open Colon Resection: a Double Blind Randomized Controlled Trial Unknown status NCT03198338 0.25% Bupivacaine, 0.5mL/kg;Normal Saline
8 Intestinal Perforation in Patients Receiving an Orthtopic Liver Transplantation in the Montpellier University Hospital: a Retrospective and Observational Study. Completed NCT04180735
9 Effect of Continuous Thoracic Epidural Analgesia on Gut Motility Following Emergency Laparotomy for Intestinal Perforation Under General Anesthesia Completed NCT03145389
10 A Multi-center Randomized Trial of Laparotomy vs. Drainage as the Initial Surgical Therapy for ELBW Infants With Necrotizing Enterocolitis (NEC) or Isolated Intestinal Perforation (IP): Outcomes at 18-22 Months Adjusted Age Completed NCT01029353
11 Observational Study of Surgical Treatment of Necrotizing Enterocolotis or Isolated Intestinal Perforation Completed NCT01223261
12 Evaluation of the Ability to Detect Bowel Gas During Laparoscopic Surgery Completed NCT02679118
13 The Role of Indocyanine Green Angiography Fluorescence on Intestinal Resections in Pediatric Surgery. Completed NCT04020939 Indocyanine Green
14 Pathophysiology of Perioperative Fluid Management in Patients Un-dergoing High Risk Emergency Laparotomy, a Prospective Descriptive Cohort Study Completed NCT03997721
15 Procalcitonin Ratio's Impact on the Decision Upon On-demand Relaparotomy in Septic Peritonitis Completed NCT01768936
16 The Risk Factors for Bowel Perforation in Neonates With Hirschsprung Disease Completed NCT05044741
17 Enhanced Recovery After Surgery Versus Conventional Approach in Peptic Perforation-A Randomized Control Trial Completed NCT04194060
18 Early Supplementation of Enteral Lipid With Combination of Microlipid and Fish Oil in Infants With Enterostomy Completed NCT01306838 Early Phase 1
19 Small Bowel Perforations: Etiology, Treatment and Outcome Completed NCT05471999
20 Observational Study of Relationship Between Intra-abdominal Hypertension and Severe Sepsis in Surgical Patients Completed NCT01784458
21 An Open-label Effectiveness Study of a Typhoid Conjugate Vaccine in Kisantu, Democratic Republic of Congo (TyVECO) - Step 3: Surveillance Protocol Recruiting NCT05562102
22 A Prospective Tolerability and Safety Study of a Powdered Human Milk-based Breastmilk Fortifier (Neokare) in Neonates With Gastrointestinal Problems Recruiting NCT05293353
23 Direct Peritoneal Resuscitation for Intra-abdominal Catastrophes Recruiting NCT05208489
24 COMPARISON OF CONTINUOUS VERSUS INTERRUPTED-X SUTURING TECHNIQUE FOR CLOSURE OF RECTUS SHEATH IN PATIENTS UNDERGOING EMERGENCY LAPAROTOMY FOR HOLLOW VISCUS PERFORATION Recruiting NCT05632146
25 Delayed Small-Bowel Anastomosis in Patients With Postoperative Peritonitis Due to Nontraumatic Small-Bowel Perforation and Anastomotic Leak: Cohort Study Active, not recruiting NCT03690687
26 Standardized Perioperative Management of Patients Operated With Acute Abdominal Surgery in a High-risk Emergency Setting Active, not recruiting NCT03549624
27 Prospective Registry The Treatment Of Upper And Lower Intestinal Anastomotic Leaks And Perforations Active, not recruiting NCT02477930
28 Is TIme From adMission to surgEry an Independent Prognostic Factor for Survival of Patients With Gastro-intestinal Perforation Associated With Septic Shock: (TIME) An Italian Intersocietary Retrospective and Prospective Observational Trial Enrolling by invitation NCT04811755
29 Impact of Abdominal Drains on the Efficacy of ERAS Pathway in the Perioperative Management of Peptic Perforation - A Randomized Control Trail (TUBELESS TRAIL) Not yet recruiting NCT05368233
30 Effect of Implementation of the Danish Emergency Surgery (DANAKIR) Support Network on Post-discharge Outcomes After Major Emergency Abdominal Surgery: a Prospective Before And-after Study Not yet recruiting NCT05442164

Search NIH Clinical Center for Intestinal Perforation

Cochrane evidence based reviews: intestinal perforation

Genetic Tests for Intestinal Perforation

Anatomical Context for Intestinal Perforation

Organs/tissues related to Intestinal Perforation:

MalaCards : Liver, Colon, Small Intestine, Lung, Kidney, Bone, Bone Marrow

Publications for Intestinal Perforation

Articles related to Intestinal Perforation:

(show top 50) (show all 2578)
# Title Authors PMID Year
1
[New treatment concepts for colonic injury after percutaneous nephrolithotomy]. 62
35925105 2022
2
Review of Necrotizing Enterocolitis and Spontaneous Intestinal Perforation Clinical Presentation, Treatment, and Outcomes. 62
36328610 2022
3
Network pharmacology and in vivo experiment-based strategy to investigate mechanisms of JingFangFuZiLiZhong formula for ulcerative colitis. 62
36382627 2022
4
Patent ductus arteriosus and spontaneous intestinal perforation in a cohort of preterm infants. 62
35589970 2022
5
Anastomosis near to the ileocecal valve in neonates with focal intestinal perforation, is it safe. 62
34096446 2022
6
Comparison of treatment outcomes between first-line chemotherapy with or without bevacizumab for advanced ovarian, fallopian tube, and primary peritoneal cancer (Tohoku gynecologic cancer unit: TGCU-RS001 study). 62
36214925 2022
7
Effect of immunosuppressive medication on postoperative complications following abdominal surgery in Crohn's disease patients. 62
36441196 2022
8
The efficacy and safety of an improved percutaneous peritoneal dialysis catheter placement technique in urgent-start peritoneal dialysis patients: a retrospective cohort study. 62
36464964 2022
9
A Biomarker-Responsive Nanosystem with Colon-Targeted Delivery for Ulcerative Colitis's Detection and Treatment with Optoacoustic/NIR-II Fluorescence Imaging. 62
36098246 2022
10
Sharp-pointed foreign body ingestion in pediatric age. 62
36346952 2022
11
[Effect of intestinal obstruction stent combined with neoadjuvant chemotherapy on the pathological characteristics of surgical specimens in patients with complete obstructive colorectal cancer]. 62
36396377 2022
12
Mortality and neurodevelopmental outcomes of infants with spontaneous intestinal perforation: a systematic review and meta-analysis. 62
36328412 2022
13
Feasibility and Impact of a Pilot Neonatal Cuddler Program on Preterm Infants in the Neonatal Intensive Care Unit. 62
36451624 2022
14
Early antibiotic use and incidence of necrotising enterocolitis in very preterm infants: a protocol for a UK based observational study using routinely recorded data. 62
36379645 2022
15
Long-Term Outcome of Necrotizing Enterocolitis and Spontaneous Intestinal Perforation. 62
36200375 2022
16
Shanghai Fever: Not Only an Asian Disease. 62
36365057 2022
17
[Nonagenarian with intestinal perforation and atypical course]. 62
36280548 2022
18
Prophylactic mesh placement in emergency midline laparotomy for intestinal perforation peritonitis: An appeal for caution. 62
35747937 2022
19
Laparoscopic transabdominal preperitoneal repair for recurrent obturator hernia initially treated by open mesh plug repair: A case report with video. 62
35534991 2022
20
Mechanical intestinal obstruction in underweight, elderly women due to an incarcerated obturator hernia. 62
36086938 2022
21
Successful early diagnosis of monomorphic epitheliotropic intestinal T-cell lymphoma manifesting as chronic diarrhea and hypokalemia using video capsule endoscopy and double-balloon enteroscopy. 62
35907086 2022
22
A rare postoperative complication of intestinal perforation in retroperitoneal aggressive fibromatosis. 62
35534330 2022
23
Combination chemotherapy with NAB® -paclitaxel and capecitabine for patients with advanced biliary tract cancer (NAP-CAPABIL Pilot Study). 62
34180586 2022
24
Endoscopy in Infants With Gastrointestinal Bleeding Has Limited Diagnostic or Therapeutic Benefit. 62
35848737 2022
25
Operative Volume of Newborn Surgery in German University Hospitals: High Volume Versus Low Volume Centers. 62
35026856 2022
26
Use of a bDMARD or tsDMARD for the management of inflammatory arthritis under checkpoint inhibitors: an observational study. 62
36270747 2022
27
Development of necrotizing enterocolitis after blood transfusion in very premature neonates. 62
36227506 2022
28
Mini-laparoscopy as a diagnostic tool for abdominal tuberculosis: a retrospective series of 29 cases. 62
36229559 2022
29
Pelvic Artificial Isolation with Ultrasound-Guided Fluid: A New Technique In Ovarian Endometriotic Cyst Transabdominal Sclerotherapy. 62
36303417 2022
30
Seat belt syndrome is caused by a different mechanism: A case report. 62
36007407 2022
31
Efficacy and safety of dilpacimab (ABT-165) versus bevacizumab plus FOLFIRI in metastatic colorectal cancer: a phase II study. 62
35920133 2022
32
The Metabolome and the Gut Microbiota for the Prediction of Necrotizing Enterocolitis and Spontaneous Intestinal Perforation: A Systematic Review. 62
36145235 2022
33
Early empirical antibiotics and adverse clinical outcomes in infants born very preterm: A population-based cohort. 62
36179887 2022
34
Advanced ovarian cancer that resulted in death from intestinal perforation following tumor lysis syndrome: A case report. 62
35994800 2022
35
Enterococcus gallinarum group meningitis after transanal migration of the ventriculoperitoneal shunt: a pediatric case report. 62
36153363 2022
36
Lithopedion as a factor in post-traumatic intestinal perforation. 62
35635273 2022
37
Coexistence of Colon Perforation and Congenital Lipodystrophy. 62
36089727 2022
38
Short bevacizumab infusion as an effective and safe treatment for colorectal cancer. 62
35949896 2022
39
Primary gastrointestinal lymphoma with intestinal perforation. 62
36171680 2022
40
Intestinal Nutrition Played a Vital Important Role in an Intestinal Perforation Patient with Chronic Constipation: A Case Report. 62
36074966 2022
41
COVID-19 infection and large intestinal perforation: A case series. 62
36027834 2022
42
Metastatic melanoma causing small intestinal perforation at the jejunojejunostomy after Roux-en-Y gastric bypass: a case report. 62
36069503 2022
43
Emergency Department Point-of-Care Ultrasound Diagnosis of a Large Bowel Obstruction Due to Metastatic Rectal Cancer: A Case Report. 62
36225420 2022
44
Insidious Onset of Localised Small Intestinal Perforation by Ingested Plastic Fork. 62
35932137 2022
45
Variation in Complications and Mortality According to Infant Diagnosis. 62
35943204 2022
46
Tolerance of hydrocortisone prophylaxis administration in extreme preterm neonates: Experience of a single UK level III neonatal unit. 62
35907315 2022
47
A fatal neonatal case of fungemia due to Exophiala dermatitidis-case report and literature review. 62
35948953 2022
48
Outcomes of Inflammatory Bowel Disease in Hospitalized Patients With Generalized Anxiety Disorder. 62
36072180 2022
49
Immunotherapy-induced Colitis: A Comprehensive Review of Epidemiology, Clinical Presentation, Diagnostic Workup, and Management Plan. 62
35470301 2022
50
Post-polypectomy syndrome-a rare complication in colonoscopy procedures: a case report. 62
36051004 2022

Variations for Intestinal Perforation

Expression for Intestinal Perforation

Search GEO for disease gene expression data for Intestinal Perforation.

Pathways for Intestinal Perforation

Pathways related to Intestinal Perforation according to GeneCards Suite gene sharing:

(show all 43)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.96 VEGFA TNF NOS1 NOD2 NFKB1 IL6
2
Show member pathways
13.3 VEGFA TNF NOD2 NFKB1 IL6 IL10
3
Show member pathways
12.53 TNF NOS1 NFKB1 IL6 IL10 CD4
4
Show member pathways
12.49 TNF NOD2 NFKB1 IL6
5 12.17 VEGFA TNF NFKB1 IL6
6 12.11 VEGFA TNF NFKB1 IL6 IL10
7
Show member pathways
12.07 TNF NFKB1 IL10 CD8A CD4
8 12 TNF NOS1 NFKB1 IL6 IL10
9 11.96 IL10 IL6 TNF VEGFA
10
Show member pathways
11.92 TNF IL6 IL10 CD4
11 11.9 TNF IL6 IL10 CD8A CD4
12 11.89 VEGFA IL6 IL10 CCR6
13
Show member pathways
11.78 CD4 CD8A CRP IL6
14 11.76 VEGFA TNF NFKB1 IL6
15 11.74 IL6 IL10 CD4
16 11.73 TNF IL6 IL10 CRP
17 11.7 NFKB1 IL6 CD4
18
Show member pathways
11.66 VEGFA TNF NFKB1 IL6
19 11.64 IL10 IL6 NFKB1 TNF
20 11.63 IL10 IL6 NFKB1 TNF
21 11.59 IL6 NFKB1 VEGFA
22 11.59 CD4 NFKB1 TNF
23 11.55 TNF NFKB1 IL10
24 11.55 TNF NFKB1 IL10 CD4
25 11.51 IL10 IL6 TNF
26 11.49 IL6 NFKB1 NOD2 TNF
27 11.46 TNF NFKB1 IL6
28 11.46 TNF IL10 CD8A CD4 CCR6
29 11.3 VEGFA TNF NFKB1
30 11.29 TNF NFKB1 IL6
31 11.27 TNF NFKB1 IL6
32 11.25 TNF NFKB1 IL6 IL10
33 11.22 TNF IL6 IL10 CD8A CD4
34 11.17 TNF NOD2 NFKB1
35 11.13 TNF IL6 IL10 CD4
36 11.1 NFKB1 IL6 IL10
37 11.07 IL6 NFKB1 TNF VEGFA
38 11.05 TNF IL6 CRP
39 10.99 VEGFA TNF IL6 IL10
40 10.92 VEGFA NOS1 NFKB1
41
Show member pathways
10.79 TNF NOD2 NFKB1 IL6 IL10
42 10.69 VEGFA NFKB1
43
Show member pathways
10.36 TNF IL6

GO Terms for Intestinal Perforation

Biological processes related to Intestinal Perforation according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 10.18 TNF IL6 IL10 CD8A CD4 CCR6
2 defense response to Gram-positive bacterium GO:0050830 10.05 TNF NOD2 IL6 CRP
3 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 10.03 VEGFA NOD2 IL6 CD4
4 positive regulation of receptor signaling pathway via JAK-STAT GO:0046427 9.97 IL10 IL6 TNF
5 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.97 VEGFA TNF NOS1 IL6
6 liver regeneration GO:0097421 9.93 TNF IL6 IL10
7 cellular response to lipopolysaccharide GO:0071222 9.91 IL10 IL6 NFKB1 NOD2 TNF
8 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.88 IL6 NOD2 TNF
9 negative regulation of interleukin-18 production GO:0032701 9.78 NOD2 IL10
10 positive regulation of MAPK cascade GO:0043410 9.76 VEGFA TNF NOD2 IL6 CD4
11 chronic inflammatory response to antigenic stimulus GO:0002439 9.62 TNF IL10
12 negative regulation of interleukin-12 production GO:0032695 9.43 NOD2 NFKB1 IL10
13 negative regulation of lipid storage GO:0010888 9.1 TNF IL6 CRP

Molecular functions related to Intestinal Perforation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 P-type potassium transmembrane transporter activity GO:0008556 8.96 ATP4A ATP12A
2 P-type potassium:proton transporter activity GO:0008900 8.92 ATP4A ATP12A

Sources for Intestinal Perforation

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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