MCID: INT071
MIFTS: 45

Intestinal Perforation

Categories: Gastrointestinal diseases

Aliases & Classifications for Intestinal Perforation

MalaCards integrated aliases for Intestinal Perforation:

Name: Intestinal Perforation 12 44 15 73
Perforation of Intestine 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2074
ICD9CM 35 569.83
MeSH 44 D007416
NCIt 50 C39611
SNOMED-CT 68 56905009
ICD10 33 K63.1
UMLS 73 C0021845

Summaries for Intestinal Perforation

MalaCards based summary : Intestinal Perforation, also known as perforation of intestine, is related to pleomorphic carcinoma and adenosquamous carcinoma. An important gene associated with Intestinal Perforation is NFKB1 (Nuclear Factor Kappa B Subunit 1), and among its related pathways/superpathways are Innate Immune System and Doxorubicin Pathway, Pharmacokinetics. The drugs Menthol and Celecoxib have been mentioned in the context of this disorder. Affiliated tissues include colon, small intestine and liver, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Intestinal Perforation

Diseases related to Intestinal Perforation via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 171)
# Related Disease Score Top Affiliating Genes
1 pleomorphic carcinoma 30.2 KRT7 NKX2-1
2 adenosquamous carcinoma 29.5 KRT7 NKX2-1
3 intestinal obstruction 29.3 KRT7 NOD2
4 small cell cancer of the lung 28.6 KRT7 NCAM1 NKX2-1
5 spondyloarthropathy 1 28.5 CRP NOD2
6 perinatal intestinal perforation 12.3
7 hirschsprung disease 1 10.9
8 solid adenocarcinoma with mucin production 10.5 KRT7 NKX2-1
9 ovarian germ cell teratoma 10.5 KRT7 NKX2-1
10 lung acinar adenocarcinoma 10.5 KRT7 NKX2-1
11 small cell carcinoma of the bladder 10.5 KRT7 NKX2-1
12 ovarian germ cell cancer 10.5 KRT7 NKX2-1
13 mucinous bronchioloalveolar adenocarcinoma 10.5 KRT7 NKX2-1
14 papillary adenoma 10.5 KRT7 NKX2-1
15 bronchiolo-alveolar adenocarcinoma 10.5 KRT7 NKX2-1
16 papillary serous adenocarcinoma 10.5 KRT7 NKX2-1
17 pulmonary sclerosing hemangioma 10.4 KRT7 NKX2-1
18 atypical choroid plexus papilloma 10.4 KRT7 NKX2-1
19 sclerosing hemangioma 10.4 KRT7 NKX2-1
20 peritonitis 10.4
21 dyskinetic cerebral palsy 10.4 NKX2-1 PTS
22 cystic teratoma 10.4 KRT7 NKX2-1
23 enterocolitis 10.4
24 tetrahydrobiopterin deficiency 10.4 NOS1 PTS
25 perinatal necrotizing enterocolitis 10.4
26 horseshoe kidney 10.3 KRT7 NKX2-1
27 ovarian cystic teratoma 10.3 KRT7 NKX2-1
28 hidradenocarcinoma 10.3 KRT7 NKX2-1
29 benign mesothelioma 10.3 KRT7 NKX2-1
30 mucinous adenocarcinoma 10.2 KRT7 NKX2-1
31 papillary adenocarcinoma 10.2 KRT7 NKX2-1
32 mesenteric lymphadenitis 10.2 CRP NOD2
33 anal gland adenocarcinoma 10.2 CRP KRT7
34 streptococcal meningitis 10.1 CRP NOD2
35 typhoid fever 10.1
36 lymphoma 10.0
37 rete testis neoplasm 10.0 NCAM1 NKX2-1
38 purpura 9.9
39 ovarian large-cell neuroendocrine carcinoma 9.9 KRT7 NCAM1
40 sensory organ benign neoplasm 9.9 KRT7 NCAM1
41 aging 9.9
42 polyarteritis nodosa, childhood-onset 9.9
43 crohn's disease 9.9
44 polyarteritis nodosa 9.9
45 miliary tuberculosis 9.9
46 cytomegalovirus infection 9.9
47 renal adenoma 9.9 KRT7 NCAM1
48 epithelial predominant wilms' tumor 9.9 KRT7 NCAM1
49 pancreatic serous cystadenoma 9.9 KRT7 NCAM1
50 malignant atrophic papulosis 9.9

Comorbidity relations with Intestinal Perforation via Phenotypic Disease Network (PDN): (show all 15)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Acute Vascular Insufficiency of Intestine
Cecal Benign Neoplasm Colorectal Cancer
Deficiency Anemia Familial Atrial Fibrillation
Heart Disease Intestinal Obstruction
Paralytic Ileus Peritonitis
Protein-Energy Malnutrition Rectosigmoid Junction Neoplasm
Respiratory Failure

Graphical network of the top 20 diseases related to Intestinal Perforation:



Diseases related to Intestinal Perforation

Symptoms & Phenotypes for Intestinal Perforation

GenomeRNAi Phenotypes related to Intestinal Perforation according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-111 9.36 NOD2
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-148 9.36 CRP
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.36 CRP
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.36 KRT7 NOD2 CRP
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.36 KRT7
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-72 9.36 KRT7
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-77 9.36 NOD2
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-89 9.36 CRP
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.36 KRT7

MGI Mouse Phenotypes related to Intestinal Perforation:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.02 NKX2-1 NOD2 NOS1 PTS NFKB1

Drugs & Therapeutics for Intestinal Perforation

Drugs for Intestinal Perforation (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 175)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Menthol Approved Phase 4,Not Applicable 2216-51-5 16666
2
Celecoxib Approved, Investigational Phase 4 169590-42-5 2662
3
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
4
Omeprazole Approved, Investigational, Vet_approved Phase 4 73590-58-6 4594
5
Ibuprofen Approved Phase 4,Phase 2,Not Applicable 15687-27-1 3672
6
Naproxen Approved, Vet_approved Phase 4 22204-53-1 1302 156391
7
Glucosamine Approved, Investigational, Nutraceutical Phase 4 3416-24-8 439213
8 Analgesics Phase 4,Phase 2,Not Applicable
9 Analgesics, Non-Narcotic Phase 4,Phase 2,Not Applicable
10 Antacids Phase 4
11 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3,Not Applicable
12 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 2,Not Applicable
13 Antirheumatic Agents Phase 4,Phase 2,Not Applicable
14 Anti-Ulcer Agents Phase 4
15 Cyclooxygenase 2 Inhibitors Phase 4
16 Cyclooxygenase Inhibitors Phase 4,Phase 2,Not Applicable
17 Gastrointestinal Agents Phase 4,Not Applicable
18 Peripheral Nervous System Agents Phase 4,Phase 2,Not Applicable
19 Proton Pump Inhibitors Phase 4
20 Antimetabolites Phase 4,Phase 2,Phase 1,Not Applicable
21 Anticoagulants Phase 4
22 Fibrinolytic Agents Phase 4
23 Glucuronyl glucosamine glycan sulfate Phase 4
24 Hypoglycemic Agents Phase 4
25 Hypolipidemic Agents Phase 4
26 Lipid Regulating Agents Phase 4
27
Fluconazole Approved, Investigational Phase 3 86386-73-4 3365
28
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
29
Simethicone Approved Phase 3 8050-81-5
30
Ampicillin Approved, Vet_approved Phase 2, Phase 3 69-53-4 6249
31
Clindamycin Approved, Vet_approved Phase 2, Phase 3 18323-44-9 29029
32
Metronidazole Approved Phase 2, Phase 3 443-48-1 4173
33
Piperacillin Approved Phase 2, Phase 3 66258-76-2 43672
34
Tazobactam Approved Phase 2, Phase 3 89786-04-9 123630
35
Betamethasone Approved, Vet_approved Phase 2, Phase 3,Phase 3 378-44-9 9782
36
Histamine Approved, Investigational Phase 2, Phase 3 75614-87-8, 51-45-6 774
37
Amoxicillin Approved, Vet_approved Phase 3 26787-78-0 33613
38
Meropenem Approved, Investigational Phase 3 119478-56-7 64778 441130
39
Ergocalciferol Approved, Nutraceutical Phase 2, Phase 3 50-14-6 5280793
40
Vitamin D Approved, Nutraceutical, Vet_approved Phase 2, Phase 3 1406-16-2
41
Vitamin D3 Approved, Nutraceutical Phase 2, Phase 3,Phase 3 67-97-0 6221 5280795
42
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3,Phase 2,Phase 1 59-30-3 6037
43
leucovorin Approved, Nutraceutical Phase 3,Phase 2,Phase 1 58-05-9 143 6006
44
Butyric Acid Experimental, Investigational Phase 2, Phase 3,Not Applicable 107-92-6 264
45 Bone Density Conservation Agents Phase 2, Phase 3
46 Ergocalciferols Phase 2, Phase 3
47 Micronutrients Phase 2, Phase 3,Phase 3
48 Trace Elements Phase 2, Phase 3,Phase 3
49 Vitamins Phase 2, Phase 3,Phase 3
50 Antifungal Agents Phase 3

Interventional clinical trials:

(show top 50) (show all 99)
# Name Status NCT ID Phase Drugs
1 Study of Tomography of Nephrolithiasis Evaluation Completed NCT01451931 Phase 4
2 Study Of Celecoxib Or Diclofenac And Omeprazole For Gastrointestinal (GI) Safety In High GI Risk Patients With Arthritis Completed NCT00141102 Phase 4 Celecoxib;Diclofenac + Omeprazole
3 Effect of Early Nutritional Therapy on Frailty, Functional Outcomes and Recovery of Undernourished Medical Inpatients Trial Completed NCT02517476 Phase 4
4 GI-Reasons- A Trial Of GI Safety Of Celecoxib Compared With Non-Selective Nonsteroidal Antiinflammatory Drugs (NSAIDS) Completed NCT00373685 Phase 4 Celecoxib;Any commercially available NSAID with the indication for osteoarthritis
5 Prospective Randomized Evaluation Of Celecoxib Integrated Safety Vs Ibuprofen Or Naproxen Completed NCT00346216 Phase 4 celecoxib;Ibuprofen;Naproxen
6 Evaluation of Use of Plastic Bags to Prevent Neonatal Hypothermia-Part IV Completed NCT01604447 Phase 4
7 Evaluate the Use of Plastic Bags in Preventing and Treating Hypothermia in Neonates Completed NCT01403623 Phase 4
8 TRAP Intervention STudy: Early Versus Late Intervention for Twin Reversed Arterial Perfusion Sequence Recruiting NCT02621645 Phase 4
9 Lactoferrin for the Treatment of Symptomatic Uncomplicated Diverticular Disease Not yet recruiting NCT03490279 Phase 4
10 Comparison of Infant Pain Responses Between Two Different Methods of Urine Collection Unknown status NCT00298584 Phase 3
11 A Randomized Trial of Docosahexaenoic Acid Supplementation During Pregnancy to Prevent Deep Placentation Disorders Unknown status NCT02336243 Phase 3
12 Vitamin D Supplementation for Extremely Preterm Infants Completed NCT01600430 Phase 2, Phase 3
13 Fluconazole Prophylaxis for the Prevention of Candidiasis in Infants Less Than 750 Grams Birthweight Completed NCT00734539 Phase 3 fluconazole;placebo
14 Hartmann's Versus Primary Anastomosis in Left-sided Colon Perforation Completed NCT01233713 Phase 2, Phase 3
15 Antibiotic Safety (SCAMP) Completed NCT01994993 Phase 2, Phase 3 ampicillin and metronidazole and gentamicin;ampicillin and gentamicin and clindamycin;gentamicin and Piperacillin- tazobactam;standard of care antibiotics and metronidazole;metronidazole, clindamycin, or piperacillin-tazobactam
16 High Dose Folic Acid Supplementation Throughout Pregnancy for Preeclampsia Prevention Completed NCT01355159 Phase 3 Folic Acid 4 mg;Placebo
17 Transvaginal Ultrasound Cervical Length Screening in Singleton Pregnancy Without Prior Spontaneous Preterm Birth Recruiting NCT02928302 Phase 3
18 Eculizumab in Shiga-toxin Related Hemolytic and Uremic Syndrome Pediatric Patients - ECULISHU Recruiting NCT02205541 Phase 3 Eculizumab;Placebo
19 Does a Rescue Course of Betamethasone in Pregnant Women With PPROM Decrease Neonatal Morbidity? Recruiting NCT02939742 Phase 2, Phase 3 Betamethasone;Placebo
20 Antenatal Late Preterm Steroids (ALPS): A Randomized Placebo-Controlled Trial Active, not recruiting NCT01222247 Phase 3 Betamethasone 3 MG/ML;Placebo
21 A Randomized Trial to Prevent Congenital Cytomegalovirus (CMV) Active, not recruiting NCT01376778 Phase 3 CMV hyperimmune globulin
22 Effects of Recto-colic Enemas of Butyrate on the Digestive Disorders of Very Low Birth Weight Preterms <1250 Grams Terminated NCT01536483 Phase 2, Phase 3 Butyrate enemas
23 A Safety and Tolerability Study of Doripenem Compared With Meropenem in Children Hospitalized With Complicated Intra-abdominal Infections Terminated NCT01110382 Phase 3 Doripenem;Meropenem placebo;Meropenem;Doripenem placebo;Amoxicillin/clavulanate potassium
24 Early Treatment Versus Delayed Conservative Treatment of the Patent Ductus Arteriosus Completed NCT01958320 Phase 2
25 IPHC in Patients With Platinum-sensitive Recurrent Ovarian Cancer Completed NCT01588964 Phase 2
26 Paclitaxel and Carboplatin With Or Without Sorafenib In The First-Line Treatment Of Patients With Ovarian Cancer Completed NCT00390611 Phase 2 Sorafenib;Paclitaxel;Carboplatin
27 Vargatef in Addition to First Line Chemotherapy With Interval Debulking Surgery in Patients With Ovarian Cancer Completed NCT01583322 Phase 2 vargatef;placebo
28 Phase II Trial of FOLFOX6, Bevacizumab and Cetuximab in Patients With Colorectal Cancer Completed NCT00100841 Phase 2 oxaliplatin;leucovorin calcium;fluorouracil
29 Bevacizumab or Cetuximab And Gemcitabine Hydrochloride, Capecitabine, and Radiation Therapy in Treating Patients With Pacreatic Cancer That Has Been Completely Removed By Surgery Completed NCT00305877 Phase 2 gemcitabine hydrochloride;capecitabine
30 Trial of Vascular Endothelial Growth Factor (VEGF), Bevacizumab, in Combination With Cytotoxic Chemotherapy for Endometrial Cancer Completed NCT00879359 Phase 2 carboplatin, paclitaxel, and bevacizumab
31 Vinorelbine and Bevacizumab in Treating Older Patients With Stage III or Stage IV Non-Small Cell Lung Cancer Completed NCT00309998 Phase 2 vinorelbine tartrate
32 Effects of Extensive Abdominal Lavage on Postoperative Inflammation Following Full Thickness Excision of Deep Endometriosis Completed NCT00930696 Phase 2
33 CABI: Antibiotic Duration for Complicated Intra-ABdominal Infection Recruiting NCT03265834 Phase 2
34 Paracetamol in Patent Ductus Arteriosus Recruiting NCT02422966 Phase 2 Paracetamol;Ibuprofen
35 Bevacizumab With or Without Trebananib in Treating Patients With Recurrent Brain Tumors Active, not recruiting NCT01609790 Phase 2
36 PIPAC for Peritoneal Metastases of Colorectal Cancer Not yet recruiting NCT03246321 Phase 1, Phase 2
37 Transanal Decompression Tube Versus Stent for Acute Malignant Left-sided Colonic and Rectal Obstruction Terminated NCT02585271 Phase 2
38 Bevacizumab, Erlotinib and Capecitabine for Advanced Pancreatic Cancer Completed NCT00614653 Phase 1 Bevacizumab;Erlotinib;Capecitabine
39 Therapeutic Oxygen for Gastrointestinal Atony (TOGA) Recruiting NCT03386136 Phase 1 100% Oxygen
40 A Dose Escalation Trial of SBRT After Induction Chemotherapy for Locally Advanced Pancreatic Cancer Recruiting NCT02873598 Phase 1 FOLFIRINOX or gemcitabine/abraxane
41 A Dose Escalation Trial of Stereotactic Body Radiotherapy (SBRT) After Induction Chemotherapy for Locally Advanced Pancreatic Cancer Recruiting NCT02643498 Phase 1
42 IRT in Infants With Intestinal Perforation Unknown status NCT01530828
43 Colonic Motility in Constipation and Ageing Unknown status NCT02575742
44 Safety and Efficacy Study of Cylindrical Abdominoperineal Resection to Treat Rectal Cancer Unknown status NCT00949273
45 Observational Study of Surgical Treatment of Necrotizing Enterocolotis Completed NCT01223261
46 Evaluation of the Ability to Detect Bowel Gas During Laparoscopic Surgery Completed NCT02679118 Not Applicable
47 Procalcitonin Ratio's Impact on the Decision Upon On-demand Relaparotomy in Septic Peritonitis Completed NCT01768936
48 Early Provision of Enteral Microlipid and Fish Oil to Infants With Enterostomy Completed NCT01306838 Not Applicable
49 Effect of Continuous Thoracic Epidural Analgesia on Gut Motility Following Emergency Laparotomy Completed NCT03145389
50 Early Supplementation of Enteral Microlipid With and Without Fish Oil in Premature Infants With Enterostomies Completed NCT01674478 Not Applicable

Search NIH Clinical Center for Intestinal Perforation

Cochrane evidence based reviews: intestinal perforation

Genetic Tests for Intestinal Perforation

Anatomical Context for Intestinal Perforation

MalaCards organs/tissues related to Intestinal Perforation:

41
Colon, Small Intestine, Liver, Bone, Endothelial, Lung, Pancreas

Publications for Intestinal Perforation

Articles related to Intestinal Perforation:

(show top 50) (show all 512)
# Title Authors Year
1
Intestinal Perforation Due to Crohn's Ileitis Immunosuppression Related Lymphoma and Meckel's Diverticulum. ( 29730434 )
2018
2
Diagnosis and treatment of postoperative intestinal perforation in infants and young children with congenital heart disease: A report of three cases. ( 29731834 )
2018
3
Malignant atrophic papulosis with motor aphasia and intestinal perforation: A case report and review of published works. ( 29516548 )
2018
4
Adhesive intestinal obstruction increases the risk of intestinal perforation in peritoneal dialysis patients: a case report. ( 29954334 )
2018
5
Intestinal perforation due to typhoid fever in Karamoja (Uganda). ( 29848809 )
2018
6
Polymicrobial Anaerobic Bacteremia Caused by Butyricimonas virosa and Brachyspira pilosicoli in a Patient with Peritonitis following Intestinal Perforation. ( 29071824 )
2018
7
Clinical predictors of bevacizumab-associated intestinal perforation in non-small cell lung cancer. ( 29536229 )
2018
8
Intestinal perforation after surgical treatment for incisional hernia: iatrogenic or idiopathic? ( 29707608 )
2018
9
Sonographic and CT imaging features of intestinal perforation from a pill and packing: A case report. ( 29668604 )
2018
10
Intestinal Perforation Associated With Perinatal Asphyxia and Anaemia. ( 29077644 )
2018
11
Bevacizumab-induced intestinal perforation in a patient with inoperable breast cancer: a case report and review of the literature. ( 29580267 )
2018
12
Recurrent Spontaneous Intestinal Perforation due to STAT1 GOF Mutation. ( 29880965 )
2018
13
Intestinal perforation by a peritoneal dialysis catheter in which fungal peritonitis led to diagnosis: a rare case report. ( 29611117 )
2018
14
Delayed intestinal perforation secondary to blunt force abdominal trauma in a cat. ( 29662682 )
2018
15
Comment on: Delayed intestinal perforation and vertebral osteomyelitis after high-intensity focused ultrasound treatment for uterine leiomyoma. ( 29569640 )
2018
16
Preterm infants undergoing laparotomy for necrotizing enterocolitis or spontaneous intestinal perforation display evidence of impaired cerebrovascular autoregulation. ( 29454185 )
2018
17
Intestinal Perforation due to Deep Infiltrating Endometriosis during Pregnancy: Case Report. ( 29747214 )
2018
18
Intestinal perforation after regorafenib usage. ( 29749339 )
2018
19
Intestinal perforation secondary to strangulated internal hernia after Roux-en-Y gastric bypass. ( 29625883 )
2018
20
Management of neonatal spontaneous intestinal perforation by peritoneal needle aspiration. ( 29120457 )
2018
21
Intestinal perforation secondary to intestinal diffuse large b-cell lymphoma in a patient with coeliac disease. ( 29054322 )
2017
22
High prevalence of cytomegalovirus infection in surgical intestinal specimens from infants with necrotizing enterocolitis and spontaneous intestinal perforation: A retrospective observational study. ( 28633098 )
2017
23
Modifiable risk factors for typhoid intestinal perforations during a large outbreak of typhoid fever, Kampala Uganda, 2015. ( 28946853 )
2017
24
Intestinal perforation: an unusual complication of barium enema. ( 29085170 )
2017
25
Intestinal perforation secondary to ingested foreign bodies: a single-center experience with 38 cases. ( 28251367 )
2017
26
Congenital Infantile Fibrosarcoma Causing Intestinal Perforation in a Newborn. ( 28690909 )
2017
27
Combined use of high doses of vasopressin and corticosteroids in a patient with Crohn's disease with refractory septic shock after intestinal perforation: a case report. ( 29129185 )
2017
28
Blood Level of Inter-Alpha Inhibitor Proteins Distinguishes Necrotizing Enterocolitis From Spontaneous Intestinal Perforation. ( 27745748 )
2017
29
Delayed intestinal perforation and vertebral osteomyelitis after high-intensity focused ultrasound treatment for uterine leiomyoma. ( 28989929 )
2017
30
Multiple small intestinal perforations in a patient with Hepatitis B Virus-associated Polyarteritis Nodosa. ( 28878877 )
2017
31
A 14-year-old girl presenting with tuberculous intestinal perforation while in a temporary shelter after the 2015 earthquake in Nepal. ( 28121264 )
2017
32
Intestinal perforation that developed after chemotherapy in a patient diagnosed with non-Hodgkin lymphoma: A case report and review of literature. ( 28898795 )
2017
33
Intestinal perforation in the premature infant. ( 28854518 )
2017
34
Typhoid intestinal perforation in developing countries: Still unavoidable deaths? ( 28373758 )
2017
35
Intestinal perforation due to hemorrhagic Cytomegalovirus enteritis in a patient with severe uncontrolled lupus nephritis: a case and review of the literature. ( 28283734 )
2017
36
Intestinal perforation after nivolumab immunotherapy for a malignant melanoma: a case report. ( 28842844 )
2017
37
Intestinal Perforation during the Stabilization Period in a Preterm Infant with Congenital Diaphragmatic Hernia. ( 28868233 )
2017
38
Intestinal perforation and peritonitis due to<i>Taenia saginata</i>: A case report from Iran. ( 29276585 )
2017
39
Neonatal Appendicitis as a Rare Cause of Intestinal Perforation in a Preterm Neonate. ( 28302241 )
2017
40
Pneumoperitoneum without Intestinal Perforation in a Neonate: Case Report and Literature Review. ( 28567320 )
2017
41
Epidemiological, clinical, and therapeutic features of typhoid intestinal perforation in a rural environment of Burkina Faso. ( 28406420 )
2017
42
Risk factors for spontaneous localized intestinal perforation in the preterm infant. ( 28671044 )
2017
43
Predictive Value of the Aspartate Aminotransferase to Platelet Ratio Index for Parenteral Nutrition-Associated Cholestasis in Premature Infants With Intestinal Perforation. ( 28792861 )
2017
44
A Single-Center Experience with Very Low Birth Weight Infants and Focal Intestinal Perforation: Comparison of Primary Anastomosis versus Stoma Opening. ( 28837996 )
2017
45
Antenatal Exposure to Magnesium Sulfate and Spontaneous Intestinal Perforation and Necrotizing Enterocolitis in Extremely Preterm Neonates. ( 28494498 )
2017
46
Determinants of postoperative morbidity and mortality in children managed for typhoid intestinal perforation in Kano Nigeria. ( 29277466 )
2017
47
Treatment and outcome of intestinal perforation after liver transplant surgery in adults: a single-center experience. ( 28615946 )
2017
48
Spontaneous Intestinal Perforation in a Very Low Birth Weight Infant: Successful Management by Peritoneal Needle Suction. ( 27433457 )
2016
49
BehAset's disease with intestinal perforation: A case report. ( 27141811 )
2016
50
Congenital Mesenteric Defect: A Rare Cause of Intestinal Perforation. ( 27595576 )
2016

Variations for Intestinal Perforation

Expression for Intestinal Perforation

Search GEO for disease gene expression data for Intestinal Perforation.

Pathways for Intestinal Perforation

Pathways related to Intestinal Perforation according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.4 CRP DEFA1 DEFA4 NCAM1 NFKB1 NOD2
2
Show member pathways
10.76 NFKB1 NOS1
3 10.4 NFKB1 NOS1
4 9.98 NFKB1 NOD2

GO Terms for Intestinal Perforation

Biological processes related to Intestinal Perforation according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 innate immune response GO:0045087 9.62 CRP DEFA4 NFKB1 NOD2
2 defense response to bacterium GO:0042742 9.61 DEFA1 DEFA4 NOD2
3 antimicrobial humoral response GO:0019730 9.51 DEFA1 DEFA4
4 antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 9.49 DEFA1 DEFA4
5 killing of cells of other organism GO:0031640 9.48 DEFA1 DEFA4
6 antibacterial humoral response GO:0019731 9.46 DEFA1 DEFA4
7 defense response GO:0006952 9.43 DEFA1 DEFA4 NOD2
8 defense response to fungus GO:0050832 9.4 DEFA1 DEFA4
9 innate immune response in mucosa GO:0002227 9.37 DEFA1 DEFA4
10 cellular response to lipopolysaccharide GO:0071222 9.33 DEFA1 DEFA4 NFKB1
11 defense response to Gram-positive bacterium GO:0050830 9.13 CRP DEFA1 DEFA4
12 membrane disruption in other organism GO:0051673 8.62 DEFA1 DEFA4

Sources for Intestinal Perforation

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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