MCID: INT071
MIFTS: 51

Intestinal Perforation

Categories: Gastrointestinal diseases

Aliases & Classifications for Intestinal Perforation

MalaCards integrated aliases for Intestinal Perforation:

Name: Intestinal Perforation 12 43 15 17 71
Perforation of Intestine 12 32

Classifications:



External Ids:

Disease Ontology 12 DOID:2074
ICD9CM 34 569.83
MeSH 43 D007416
NCIt 49 C39611
SNOMED-CT 67 56905009
ICD10 32 K63.1
UMLS 71 C0021845

Summaries for Intestinal Perforation

MalaCards based summary : Intestinal Perforation, also known as perforation of intestine, is related to ileus and behcet syndrome. An important gene associated with Intestinal Perforation is NOD2 (Nucleotide Binding Oligomerization Domain Containing 2), and among its related pathways/superpathways are Toll-Like receptor Signaling Pathways and T cell receptor signaling pathway. The drugs Clavulanate and Amoxicillin have been mentioned in the context of this disorder. Affiliated tissues include colon, small intestine and liver, and related phenotypes are homeostasis/metabolism and digestive/alimentary

Related Diseases for Intestinal Perforation

Diseases related to Intestinal Perforation via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 776)
# Related Disease Score Top Affiliating Genes
1 ileus 30.9 TNF IL6 CRP
2 behcet syndrome 30.8 VEGFA TNF TLR4 NOD2 IL6 CTLA4
3 patent ductus arteriosus 1 30.7 VEGFA PRODH CRP ALB
4 miliary tuberculosis 30.7 TNF CRP ALB
5 cytomegalovirus infection 30.6 TNF NFKB1 IL6
6 peritonitis 30.6 TNF TLR4 IL6 CRP ALB
7 intestinal tuberculosis 30.6 TNF NOD2 CRP ALB
8 purpura 30.5 TNF IL6 CRP
9 polyarteritis nodosa 30.5 IL6 GPT CRP
10 intussusception 30.5 VEGFA IL6 CRP ALB
11 perinatal necrotizing enterocolitis 30.3 TNF TLR4 NOD2 IL6 FABP2 CRP
12 necrotizing fasciitis 30.3 IL6 CRP ALB
13 tuberculous peritonitis 30.2 CRP ALB
14 vasculitis 30.2 TNF IL6 CTLA4 CRP
15 gastroenteritis 30.2 TNF IL6 CRP ALB
16 fasciitis 30.1 TNF IL6 CRP
17 acquired immunodeficiency syndrome 30.1 TNF IL6 CRP ALB
18 toxic shock syndrome 30.1 TNF TLR4 IL6 CRP
19 gastrointestinal tuberculosis 30.1 TNF NOD2 CRP ALB
20 typhoid fever 30.1 TNF TLR4 IL6 GPT CRP ALB
21 superior mesenteric artery syndrome 30.0 CRP ATP4A ATP12A
22 gastric dilatation 30.0 CRP ATP4A ATP12A
23 covid-19 30.0 IL6 GPT CRP
24 amebiasis 30.0 TNF TLR4 ALB
25 abdominal tuberculosis 30.0 TNF GPT CRP ALB
26 active peptic ulcer disease 30.0 CRP ATP4A ATP12A ALB
27 funisitis 29.9 TNF IL6 CRP
28 cholestasis 29.9 TNF IL6 GPT ALB
29 crohn's disease 29.9 TNF TLR4 NOD2 IL6 CRP ALB
30 appendicitis 29.9 TNF TLR4 IL6 CRP ALB
31 mycobacterium tuberculosis 1 29.9 TNF TLR4 PRODH NOD2 CRP
32 diaphragmatic hernia, congenital 29.9 VEGFA NKX2-1 ATP4A ATP12A
33 angiodysplasia 29.9 VEGFA ATP4A ATP12A
34 eosinophilic gastroenteritis 29.9 ATP4A ATP12A ALB
35 disseminated intravascular coagulation 29.9 TNF IL6 GPT CRP
36 infective endocarditis 29.9 TNF IL6 CRP
37 diverticulitis 29.8 TNF IL6 CRP ATP4A ATP12A ALB
38 gastric ulcer 29.8 VEGFA TNF IL6
39 spondylitis 29.8 TNF NOD2 IL6 CRP
40 amyloidosis 29.8 TNF IL6 CRP ALB
41 volvulus of midgut 29.8 GPT CRP ATP4A ATP12A ALB
42 brucellosis 29.7 TNF TLR4 IL6 CRP
43 mediastinitis 29.7 CRP ATP4A ATP12A ALB
44 lung abscess 29.7 TNF IL6 CRP ALB
45 pneumocystosis 29.7 TNF IL6 CRP ALB
46 synovitis 29.7 VEGFA TNF IL6 CRP
47 iridocyclitis 29.7 VEGFA TNF IL6 CRP
48 peptic ulcer disease 29.7 TNF PRODH ATP4A ATP12A ALB
49 endocarditis 29.7 TNF IL6 CRP ALB
50 osteomyelitis 29.7 TNF TLR4 NOD2 IL6

Comorbidity relations with Intestinal Perforation via Phenotypic Disease Network (PDN): (show all 15)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Acute Vascular Insufficiency of Intestine
Cecal Benign Neoplasm Colorectal Cancer
Deficiency Anemia Familial Atrial Fibrillation
Heart Disease Intestinal Obstruction
Paralytic Ileus Peritonitis
Protein-Energy Malnutrition Rectosigmoid Junction Neoplasm
Respiratory Failure

Graphical network of the top 20 diseases related to Intestinal Perforation:



Diseases related to Intestinal Perforation

Symptoms & Phenotypes for Intestinal Perforation

MGI Mouse Phenotypes related to Intestinal Perforation:

45 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.43 ALB ATP12A ATP4A CRP CTLA4 FABP2
2 digestive/alimentary MP:0005381 10.34 ALB ATP12A ATP4A CTLA4 IL6 NFKB1
3 growth/size/body region MP:0005378 10.31 ATP12A FABP2 IL6 NFKB1 NKX2-1 NOD2
4 cardiovascular system MP:0005385 10.24 ALB CRP CTLA4 IL6 NKX2-1 NOS1
5 endocrine/exocrine gland MP:0005379 10.21 ALB ATP4A CTLA4 IL6 NFKB1 NKX2-1
6 mortality/aging MP:0010768 10.21 ALB ATP4A CTLA4 IL6 NFKB1 NKX2-1
7 immune system MP:0005387 10.2 ALB ATP4A CRP CTLA4 IL6 NFKB1
8 integument MP:0010771 10.09 CTLA4 IL6 NFKB1 PRODH PTS TLR4
9 liver/biliary system MP:0005370 10.06 ALB CTLA4 FABP2 IL6 NFKB1 NOS1
10 muscle MP:0005369 9.92 ALB IL6 NFKB1 NOS1 PTS TLR4
11 neoplasm MP:0002006 9.8 ALB ATP4A IL6 NKX2-1 TLR4 TNF
12 renal/urinary system MP:0005367 9.76 ALB ATP12A FABP2 IL6 KRT7 NOS1
13 respiratory system MP:0005388 9.56 CTLA4 IL6 NFKB1 NKX2-1 NOS1 TLR4
14 skeleton MP:0005390 9.36 CTLA4 GPT IL6 NFKB1 NKX2-1 NOD2

Drugs & Therapeutics for Intestinal Perforation

Drugs for Intestinal Perforation (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 48)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clavulanate Approved, Vet_approved Phase 3 58001-44-8 5280980
2
Amoxicillin Approved, Vet_approved Phase 3 26787-78-0 33613
3
Meropenem Approved, Investigational Phase 3 96036-03-2, 119478-56-7 441130 64778
4
Doripenem Approved, Investigational Phase 3 148016-81-3 73303
5 Pharmaceutical Solutions Phase 2, Phase 3
6 Anti-Infective Agents Phase 3
7 Anti-Bacterial Agents Phase 3
8 Amoxicillin-Potassium Clavulanate Combination Phase 3
9 beta-Lactamase Inhibitors Phase 3
10
Cisplatin Approved Phase 2 15663-27-1 2767 441203 84093
11
Docetaxel Approved, Investigational Phase 2 114977-28-5 148124
12
Acetaminophen Approved Phase 2 103-90-2 1983
13
Indomethacin Approved, Investigational Phase 2 53-86-1 3715
14
Petrolatum Approved, Investigational Phase 2 8009-03-8
15
Mupirocin Approved, Investigational, Vet_approved Phase 2 12650-69-0 446596
16 Tubulin Modulators Phase 2
17 Antimitotic Agents Phase 2
18 Dermatologic Agents Phase 2
19 Emollients Phase 2
20 Immunoglobulins Phase 1
21 Antibodies Phase 1
22 Immunoglobulins, Intravenous Phase 1
23 Antibodies, Monoclonal Phase 1
24
Bupivacaine Approved, Investigational 2180-92-9, 38396-39-3 2474
25
Lidocaine Approved, Vet_approved 137-58-6 3676
26
Ceftazidime Approved 72558-82-8, 78439-06-2 5481173
27
Vancomycin Approved 1404-90-6 14969 441141
28
Ibuprofen Approved 15687-27-1 3672
29 Anesthetics, Local
30 Tea
31 Respiratory System Agents
32 Hormones
33 Hormone Antagonists
34 glucocorticoids
35
Beclomethasone 4419-39-0 20469
36 Anti-Asthmatic Agents
37 Anesthetics
38 Lactoferrin
39 Analgesics, Opioid
40 Antibiotics, Antitubercular
41 Cola
42 Liver Extracts
43 Analgesics, Non-Narcotic
44 Analgesics
45 Cyclooxygenase Inhibitors
46 Anti-Inflammatory Agents
47 Antirheumatic Agents
48 Anti-Inflammatory Agents, Non-Steroidal

Interventional clinical trials:

(show top 50) (show all 54)
# Name Status NCT ID Phase Drugs
1 Randomized Evaluation of the Use of Plastic Bags to Prevent Neonatal Hypothermia in Developing Countries-Part IV Completed NCT01604447 Phase 4
2 Phase III Clinical Trial, Randomized, Multicentre, Double Blind to Evaluate Two Guidelines for the Administration of Ibuprofen in the Treatment of Persistent Ductus Arteriosus Eco-guided: Impact in the Intestinal Prognosis Recruiting NCT04282941 Phase 3 Ibuprofen in continuous (24 hours) iv infusion and EchoG;IV bolus Ibuprofen slow (15 minutes) and EchoG
3 Effects of Recto-colic Enemas of Butyrate on the Digestive Disorders of Very Low Birth Weight Preterms <1250 Grams. Clinical Trial Prospective, Monocentric, Randomized in Double-blinded. Terminated NCT01536483 Phase 2, Phase 3 Butyrate enemas
4 A Prospective, Randomized, Double-Blind, Multicenter Study to Establish the Safety and Tolerability of Doripenem Compared With Meropenem in Hospitalized Children With Complicated Intra-Abdominal Infections Terminated NCT01110382 Phase 3 Doripenem;Meropenem placebo;Meropenem;Doripenem placebo;Amoxicillin/clavulanate potassium
5 Phase II Study of Salvage Therapy With Sunitinib,Docetaxel and Platinum on Metastatic or Unresectable Non Small Cell Lung Cancer Unknown status NCT01019798 Phase 2 sunitinib, docetaxel, cisplatin
6 Early Treatment Versus Delayed Conservative Treatment of the Patent Ductus Arteriosus in Preterm infants-a Multicenter Trial Completed NCT01958320 Phase 2 NSAID
7 Early Supplementation of Enteral Microlipid With and Without Fish Oil in Premature Infants With Enterostomies Completed NCT01674478 Phase 2
8 Randomized Controlled Trial of Mupirocin to Reduce Staphylococcus Aureus Colonization in Infants Hospitalized in a Neonatal Intensive Care Unit Recruiting NCT02967432 Phase 2 Mupirocin Topical Ointment;Petroleum Jelly
9 A Phase II Trial of Sunitinib and Nivolumab for KIT-mutated Advanced Melanoma Withdrawn NCT02400385 Phase 2 sunitinib;nivolumab
10 An Open-Label Trial of Tocilizumab in Schizophrenia Completed NCT01696929 Phase 1 Tocilizumab
11 A Randomized Controlled Trial of Adjunctive Tocilizumab in Schizophrenia Recruiting NCT02874573 Phase 1 Tocilizumab;Normal saline
12 Immunoreactive Trypsinogen in Infants With Intestinal Perforation Unknown status NCT01530828
13 Proximal Remnant Intestinal Colonization in Newborn Infants With Enterostomy: a Longitudinal Study Unknown status NCT03340259
14 Ultrasound Guided Transversus Abdominis Plane(TAP) Block in Intensive Care Unit(ICU) for Postoperative Analgesia After Open Colon Resection: a Double Blind Randomized Controlled Trial Unknown status NCT03198338 0.25% Bupivacaine, 0.5mL/kg;Normal Saline
15 Probiotics Supplementation and Length of Hospital Stay in Neonates With Gastrointestinal Surgery Unknown status NCT03266315
16 Procalcitonin Ratio's Impact on the Decision Upon On-demand Relaparotomy in Septic Peritonitis Completed NCT01768936
17 Observational Study of Surgical Treatment of Necrotizing Enterocolotis or Isolated Intestinal Perforation Completed NCT01223261
18 Evaluation of the Ability to Detect Bowel Gas During Laparoscopic Surgery Completed NCT02679118
19 Intestinal Perforation in Patients Receiving an Orthtopic Liver Transplantation in the Montpellier University Hospital: a Retrospective and Observational Study. Completed NCT04180735
20 A Multi-center Randomized Trial of Laparotomy vs. Drainage as the Initial Surgical Therapy for ELBW Infants With Necrotizing Enterocolitis (NEC) or Isolated Intestinal Perforation (IP): Outcomes at 18-22 Months Adjusted Age Completed NCT01029353
21 Effect of Continuous Thoracic Epidural Analgesia on Gut Motility Following Emergency Laparotomy for Intestinal Perforation Under General Anesthesia Completed NCT03145389
22 Early Supplementation of Enteral Lipid With Combination of Microlipid and Fish Oil in Infants With Enterostomy Completed NCT01306838 Early Phase 1
23 Factors Associated With Relapses in Patients Suffering From Clostridium Difficile Infection: Immune Response Completed NCT02440438
24 Prediction of Feeding Problems in Prostaglandin-dependent Prematurely Born Infants With Congenital Heart Disease Completed NCT01126372
25 Splanchnic Oxygenation and Perfusion Response to Enteral Feeds in Preterm Infants With Abnormal Antenatal Doppler: Pattern Assessment and Correlation With Feeding Intolerance Completed NCT02971566
26 Splanchnic Tissue Oxygenation During Enteral Feedings in Anemic Premature Infants at Risk for Necrotizing Enterocolitis Completed NCT01735578
27 Effect of Patent Ductus Arteriosus on Splanchnic Oxygenation at Enteral Feeding Introduction in Preterm Infants Completed NCT03723889
28 Intestinal Microbiota and Short Term Outcomes in Very Low Birth Weight Infants Fed Primarily Donor Human Milk Compared to Infants Fed Primarily Mother's Own Milk Completed NCT02573779
29 A Dose-Ranging Study to Assess the Effect of Inhaled Corticosteroids in Ventilated Preterm Neonates Completed NCT03503994 Inhaled Beclomethasone Dipropionate Monohydrate
30 Prospective Registry The Treatment Of Upper And Lower Intestinal Anastomotic Leaks And Perforations Recruiting NCT02477930
31 Pathophysiology of Perioperative Fluid Management in Patients Un-dergoing High Risk Emergency Laparotomy, a Prospective Descriptive Cohort Study Recruiting NCT03997721
32 The Role of Indocyanine Green Angiography Fluorescence on Intestinal Resections in Pediatric Surgery. Recruiting NCT04020939 Indocyanine Green
33 A Randomized Multicenter Open-label Controlled Trial to Show That Mucous Fistula Refeeding Reduces the Time From Enterostomy Closure to Full Enteral Feeds (MUCous FIstula REfeeding ("MUC-FIRE") Trial) Recruiting NCT03469609
34 Symptomatic Uncomplicated Diverticular Disease: a lactofErriN piLot studY Recruiting NCT03490279
35 Enhanced Recovery After Surgery Versus Conventional Approach in Peptic Perforation-A Randomized Control Trial Recruiting NCT04194060
36 Tolerance of Early High Protein Nutrition of the Critically Ill: Comparison of a Protein-rich Enteral Formula With a Standardized High Carbohydrate Product on Total Calorie and Protein Intake Recruiting NCT02678325
37 Standardized Perioperative Management of Patients Operated With Acute Abdominal Surgery in a High-risk Emergency Setting Recruiting NCT03549624
38 Randomized Multicentric Clinical Trial, Efficcacy of the Treatment Application on Peritonitis in Automated Peritoneal Dialysis (APD); Comparision Between APD Versus Ambulatory Dialysis. Recruiting NCT04077996
39 NETs: Protection or Harm in Neonatal Inflammation or Infection Recruiting NCT00747851
40 Continuous Versus Intermittent Bolus Feeding in Very Preterm Infants - Effects on Respiratory Morbidity: A Multicentre Randomised Controlled Clinical Trial Recruiting NCT03961139
41 Safeguarding the Brain of Our Smallest Children - an Investigator-initiated, Pragmatic, Open Label, Multinational Randomized Phase IIIclinical Trial Evaluating Treatment Based on Near-infrared Spectroscopy Monitoring Versus Treatment as Usual in Premature Infants Recruiting NCT03770741
42 Non-invasive Auxiliary Diagnosis of Colorectal Cancer and Advanced Adenoma by Detecting Cancer-specific Methylation Signatures in Plasma ctDNA Recruiting NCT03828396
43 Evaluation of Post-Discharge Growth and Development of Infants Who Received Donor Human Milk Products in the NICU Active, not recruiting NCT01483079
44 Delayed Small-Bowel Anastomosis in Patients With Postoperative Peritonitis Due to Nontraumatic Small-Bowel Perforation and Anastomotic Leak: Cohort Study Active, not recruiting NCT03690687
45 Extensively Hydrolyzed Liquid Human Milk Fortifier Versus Liquid Human Milk Fortifier With Supplemental Liquid Protein Active, not recruiting NCT03001479
46 Post-Discharge Evaluation of Human Milk Cream Study Infants at 18 to 24 Month CGA: A Randomized Trial of the Use of Human Milk Cream to Decrease Length of Stay in Extremely Premature Infants Active, not recruiting NCT02475434
47 Vacuum Assisted Closure Versus On-demand Relaparotomy in Patients With Fecal or Diffuse Peritonitis: A Multicenter Randomized Controlled Trial Not yet recruiting NCT03932461
48 Doppler Ultrasonography in Assessment of Graft Hemodynamics After Living-Donor Liver Transplantation in Al-Rajhi Liver Hospital Not yet recruiting NCT03893773
49 Early Routine vs. Selective Human Milk Fortification in Extremely Preterm Infants Not yet recruiting NCT04284280
50 A Prospective Multicenter Randomized Controlled Clinical Trial to Compare the Method of Protective Diverting Loop Ileostomy With or Without the Support of a Plastic Rod Terminated NCT00959738

Search NIH Clinical Center for Intestinal Perforation

Cochrane evidence based reviews: intestinal perforation

Genetic Tests for Intestinal Perforation

Anatomical Context for Intestinal Perforation

MalaCards organs/tissues related to Intestinal Perforation:

40
Colon, Small Intestine, Liver, Lung, Bone, T Cells, Kidney

Publications for Intestinal Perforation

Articles related to Intestinal Perforation:

(show top 50) (show all 2197)
# Title Authors PMID Year
1
Idiopathic pneumoperitoneum without gastrointestinal perforation in a low-birth weight infant: A rare type of air leak syndrome. 61
32419888 2020
2
A challenging solution to a complex incisional hernia - video vignette. 61
32515112 2020
3
Asymmetric retinopathy of prematurity in presumed fungal endophthalmitis. 61
32382688 2020
4
Neonatal thrombotic microangiopathy secondary to factor I variant with Hirschsprung disease. 61
32514992 2020
5
Liver abscess caused by fish bone perforation of Meckel's diverticulum: a case report. 61
32503493 2020
6
Quality Improvement Efforts Reduce Incidence of Surgical Necrotizing Enterocolitis and Related Deaths. 61
32512607 2020
7
[Ready-to-use parenteral nutrition in a preterm infant with necrotizing enterocolitis and related complications: case report]. 61
32573561 2020
8
Chyme recycling in the management of small bowel double enterostomy in pediatric and neonatal populations: A systematic review. 61
32359729 2020
9
Complications Following the Use of Biologic Mesh in Ileostomy Closure: A Retrospective, Comparative Study. 61
32511101 2020
10
Intestinal perforations after endoscopic retrograde cholangiopancreatography in the United States: a 16-year study using the national inpatient sample. 61
32492997 2020
11
Malignant Brenner tumour of the ovary manifesting as distal intestinal obstruction and perforation. 61
32532918 2020
12
Treatment outcomes of Kugel repair for obturator hernias: a retrospective study. 61
32532257 2020
13
Fetal Meconium Peritonitis - Prenatal Findings and Postnatal Outcome: A Case Series, Systematic Review, and Meta-Analysis. 61
32575129 2020
14
The Efficacy of Over-the-Scope Clip Closure for Gastrointestinal Iatrogenic Perforation During Endoscopic Ultrasound and Endoscopic Retrograde Cholangiopancreatography for Pancreaticobiliary Diseases. 61
32141973 2020
15
Type II enteropathy-associated T cell lymphoma in the duodenum: A rare case report. 61
32501967 2020
16
Successful staged repair of pulmonary atresia, ventricular septal defect, and major aortopulmonary collateral arteries in an extremely low birth weight infant. 61
31147961 2020
17
Safety of synthetic and biological DMARDs: a systematic literature review informing the 2019 update of the EULAR recommendations for the management of rheumatoid arthritis. 61
32033941 2020
18
A role for neonatal bacteremia in deaths due to intestinal perforation: spontaneous intestinal perforation compared with perforated necrotizing enterocolitis. 61
32433511 2020
19
Analysis of Disialyllacto-N-Tetraose (DSLNT) Content in Milk From Mothers of Preterm Infants. 61
32109186 2020
20
Neurodevelopmental and growth outcomes of extremely preterm infants with necrotizing enterocolitis or spontaneous intestinal perforation. 61
32553453 2020
21
Colonic perforation in a nasopharyngeal carcinoma patient treated with fluorouracil: A case report. 61
32420303 2020
22
Tocilizumab in COVID-19: Beware the risk of intestinal perforation. 61
32389721 2020
23
Morbidity and Mortality of Typhoid Intestinal Perforation Among Children in Sub-Saharan Africa 1995-2019: A Scoping Review. 61
32430740 2020
24
Catastrophic Healthcare Expenditure from Typhoid Perforation in Children in Nigeria. 61
32423308 2020
25
Burden of Complicated Intra-Abdominal Infections in Children in Nigeria: Recent Experience and Systematic Review. 61
32453672 2020
26
Role of Nutrition in Prevention of Neonatal Spontaneous Intestinal Perforation and Its Complications: A Systematic Review. 61
32397283 2020
27
Intestinal necrosis related to administration of cation exchange resin without sorbitol: A retrospective analysis of 61 patients with end-stage renal diseases. 61
31997484 2020
28
Bowel perforation after liposuction in abdominal contouring surgery: Case report. 61
32506029 2020
29
Intestinal fistula accompanied by recurrent peritonitis associated with peritoneal dialysis: a case report. 61
32448191 2020
30
Actionable Risk Model for the Development of Surgical Site Infection after Emergency Surgery. 61
32397903 2020
31
Intestinal perforation in patient with COVID-19 infection treated with tocilizumab and corticosteroids. Report of a clinical case. 61
32402416 2020
32
Cecal Perforation by a Large Gallstone: An Unusual Diagnosis. 61
32483509 2020
33
Highly antimicrobial-resistant Nontyphoidal Salmonella from retail meats and clinical impact in children, Taiwan. 61
32340872 2020
34
New simple low-cost surgical approach to complex jejuno-ileal atresia. 61
31914866 2020
35
A novel interstitial deletion of chromosome 2q21.1-q23.3: Case report and literature review. 61
31989799 2020
36
Jejuno-jejunal intussusception caused by a percutaneous endoscopic gastrojejunostomy tube in a pediatric patient: A case report. 61
32312016 2020
37
Patient Selection for Adjuvant Chemotherapy in High-Risk Stage II Colon Cancer: A Systematic Review and Meta-Analysis. 61
31934881 2020
38
Endoscopic diagnosis of Fasciolopsis buski: Revisited (with video). 61
32280779 2020
39
Consecutive Versus Selective Primary and Revisional Single Incision Laparoscopic Bariatric Surgery: Personal Experience in 330 Cases. 61
31858397 2020
40
Injuries due to foreign body ingestion and insertion in children: 10 years of experience at a single institution. 61
31693772 2020
41
Upfront FOLFOXIRI plus bevacizumab and reintroduction after progression versus mFOLFOX6 plus bevacizumab followed by FOLFIRI plus bevacizumab in the treatment of patients with metastatic colorectal cancer (TRIBE2): a multicentre, open-label, phase 3, randomised, controlled trial. 61
32164906 2020
42
Microbiological epidemiology of preservation fluids in transplanted kidney: a nationwide retrospective observational study. 61
31382016 2020
43
A case of systemic lupus erythematosus with rectal necrosis. 61
31924142 2020
44
Clinical outcome in pediatric refractory gastrointestinal Henoch-Schönlein purpura treated with mycophenolate mofetil. 61
32144502 2020
45
An internal hernia caused by Meckel's diverticulum: a case report. 61
32164577 2020
46
Usefulness of peritoneal drainage in extremely low birth weight infants with intestinal perforation: a single-center experience. 61
32158736 2020
47
A Pharmacoepidemiologic Study of the Safety and Effectiveness of Clindamycin in Infants. 61
31725114 2020
48
Gastrointestinal involvement in adult IgA vasculitis (Henoch-Schönlein purpura): updated picture from a French multicentre and retrospective series of 260 cases. 61
32211770 2020
49
Bevacizumab-associated intestinal perforation and perioperative complications in patients receiving bevacizumab. 61
32258980 2020
50
Risk factors of meconium-related ileus in very low birth weight infants: patients-control study. 61
32170203 2020

Variations for Intestinal Perforation

Expression for Intestinal Perforation

Search GEO for disease gene expression data for Intestinal Perforation.

Pathways for Intestinal Perforation

Pathways related to Intestinal Perforation according to GeneCards Suite gene sharing:

(show all 31)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.68 TNF TLR4 NOD2 NFKB1 IL6
2
Show member pathways
12.53 TNF TLR4 NFKB1 IL6 CTLA4
3
Show member pathways
12.52 TNF TLR4 NOD2 NFKB1 IL6
4 12.27 TNF TLR4 NFKB1 IL6
5 12.23 TNF TLR4 NFKB1 IL6
6
Show member pathways
12.22 TNF TLR4 NFKB1 IL6
7
Show member pathways
12.21 TNF NFKB1 IL6 CRP ALB
8
Show member pathways
12.14 TNF TLR4 NFKB1 IL6
9 12.11 VEGFA TNF NFKB1 IL6
10 12.06 TNF TLR4 NOD2 NFKB1 IL6
11 12.02 TNF TLR4 NOD2 NFKB1 IL6
12 11.96 TNF TLR4 NFKB1 IL6
13 11.95 TNF TLR4 NOS1 IL6
14 11.9 TNF NOD2 NFKB1 IL6
15 11.87 VEGFA TLR4 NFKB1 IL6
16 11.87 VEGFA TNF TLR4 NFKB1 IL6
17 11.83 TNF TLR4 NFKB1 IL6
18 11.81 VEGFA TNF NFKB1 IL6
19 11.61 TNF TLR4 NFKB1 IL6
20 11.54 TNF TLR4 NFKB1
21 11.51 VEGFA NFKB1 IL6
22 11.5 TNF TLR4 IL6
23 11.47 VEGFA TNF NFKB1
24 11.46 TNF NFKB1 IL6
25
Show member pathways
11.42 VEGFA TNF NFKB1 IL6
26 11.23 TNF NFKB1 IL6
27 11.21 TNF TLR4 NFKB1 IL6
28 11.03 TNF NOD2 NFKB1
29 10.99 VEGFA TNF TLR4 IL6 CTLA4
30 10.91 TNF IL6 CRP
31 10.8 TNF TLR4 NFKB1 IL6

GO Terms for Intestinal Perforation

Biological processes related to Intestinal Perforation according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.97 USF2 TNF NOS1 NKX2-1 NFKB1 IL6
2 positive regulation of gene expression GO:0010628 9.93 VEGFA TNF TLR4 NKX2-1 IL6 CRP
3 inflammatory response GO:0006954 9.91 TNF TLR4 NFKB1 IL6 CRP
4 positive regulation of transcription by RNA polymerase II GO:0045944 9.91 VEGFA USF2 TNF TLR4 NOS1 NOD2
5 cellular response to lipopolysaccharide GO:0071222 9.77 TNF TLR4 NOD2 NFKB1 IL6
6 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.74 VEGFA TNF IL6
7 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.73 VEGFA TNF NOS1 IL6
8 I-kappaB kinase/NF-kappaB signaling GO:0007249 9.72 TNF TLR4 NFKB1
9 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.71 TNF TLR4 NOD2
10 positive regulation of MAP kinase activity GO:0043406 9.7 VEGFA TNF NOD2
11 positive regulation of interleukin-8 production GO:0032757 9.65 TNF TLR4 NOD2
12 positive regulation of interleukin-6 production GO:0032755 9.62 TNF TLR4 NOD2 IL6
13 positive regulation of chemokine production GO:0032722 9.58 TNF TLR4 IL6
14 cellular response to nicotine GO:0071316 9.56 TNF NFKB1
15 negative regulation of lipid storage GO:0010888 9.33 TNF IL6 CRP
16 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.26 TNF TLR4 NOD2 IL6
17 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.1 TNF TLR4 SLCO3A1 NOD2 NFKB1 IL6

Molecular functions related to Intestinal Perforation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 potassium-transporting ATPase activity GO:0008556 8.96 ATP4A ATP12A
2 potassium:proton exchanging ATPase activity GO:0008900 8.62 ATP4A ATP12A

Sources for Intestinal Perforation

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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